Dr Muh Geot Wong

Clinical Senior Lecturer
Medicine, Northern Clinical School

Telephone +61 2 9926 4773
Fax +61 2 9926 5715

Curriculum vitae Curriculum vitae

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Biographical details

Since I was awarded my PhD in 2011, I have worked as a part time clinician researcher at the Kolling Institute and at the George Institute. My main area of research is in understanding the pathomechanisms of kidney tubulointerstitial fibrosis, strategy in delaying CKD progression, and biomarkers in predicting progressive kidney disease especially in diabetic kidney disease and IgA nephropathy.I am the current Head of the Renal Clinical trial unit at the Royal North Shore Hospital (RNSH), and an active member of the a member of the Kolling Research Executive Committee for the Northern Sydney Lower Health District, which oversees the strategic development and operational effectiveness of the Clinical based research across the Area Health. I am part of the CARI guideline write-up group for Screening for infections in haemodialysis, and a member of the Scientific Program and Education Committee (SPEC) for the Australian New Zealand Society of Nephrology since 2015. I received several Young Investigator Awards and Early Career Awards at national and regional level in the past few years including the Young Investigator Awards at the Asia Pacific Congress of Nephrology, Tokyo in 2014.I successfully co-supervised two Master students and currently co-supervising two PhD students.

Research interests

My area of interest is inkidney tubulointerstitial fibrosis, strategy in delaying CKD progression, biomarkers reserach for CKD, randomised controlled clinical trials, and translational research.

Teaching and supervision

I supervise, train and examine medical students, basic physician trainees and advanced renal trainee at the Northern Clinical School. During the three years tenure as the Director of Physician Training of the Royal North Shore Hospital, forty five basic physician trainees were successful in the written and clinical Fellowship examination, with more than 95% of these trainees securing further specialty training positions. I successfully co-supervised two Master students and currently co-supervising two PhD students. Within my capacity as the Head of Renal Clinical Trial Unit, I lead a team of three Clinical Research Coordinators , and manage the daily operation, budget and contract negotiation of several clinical trials.

Selected grants

2015

  • Do circulating transforming growth factor-β1 and bone morphogenetic protein-7 predict progression of CKD in patients with type 2 diabetes mellitus; Wong M; Clive and Vera Ramaciotti Foundations/Awards for Biomedical Research: Establishment Gifts.

2014

  • The role of three novel agents in limiting kidney fibrosis in a model of diabetic nephropathy; Wong M; Royal Australasian College of Physicians/Jacquot Research Establishment Award.

Selected publications

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Journals

  • Glastras, S., Chen, H., Tsang, M., Teh, R., McGrath, R., Zaky, A., Chen, J., Wong, M., Pollock, C., Saad, S. (2017). The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet. PloS One, 12(2), 1-17. [More Information]
  • Gallagher, M., Wong, M., Perkovic, V. (2016). ALTITUDE: defining a ceiling for blockade of the renin-angiotensin system? The Lancet Diabetes & Endocrinology, 4(4), 289-290. [More Information]
  • Sukkar, L., Hong, D., Wong, M., Badve, S., Rogers, K., Perkovic, V., Walsh, M., Yu, X., Hillis, G., Gallagher, M., Jardine, M. (2016). Effects of ischaemic conditioning on major clinical outcomes in people undergoing invasive procedures: systematic review and meta-analysis. BMJ, 355, 1-10. [More Information]
  • Liyanage, T., Ninomiya, T., Wang, Y., Neal, B., Jun, M., Wong, M., Jardine, M., Hillis, G., Perkovic, V. (2016). Effects of the mediterranean diet on cardiovascular outcomes-a systematic review and meta-analysis. PloS One, 11(8), 1-11. [More Information]
  • Wong, M., Perkovic, V. (2016). Knowing what we do not know: statin therapy in advanced chronic kidney disease. The Lancet Diabetes & Endocrinology, 4(10), 801-803. [More Information]
  • Wong, M., Perkovic, V., Chalmers, J., Woodward, M., Li, Q., Cooper, M., Hamet, P., Harrap, S., Heller, S., MacMahon, S., Neal, B., Rodgers, A., Zoungas, S., et al (2016). Long-term Benefits of Intensive Glucose Control for Preventing End-Stage Kidney Disease: ADVANCE-ON. Diabetes Care, 39(5), 694-700. [More Information]
  • Glastras, S., Chen, H., Teh, R., McGrath, R., Chen, J., Pollock, C., Wong, M., Saad, S. (2016). Mouse models of diabetes, obesity and related kidney disease. PloS One, 11(8), 1-15. [More Information]
  • Stangenberg, S., Chen, H., Wong, M., Pollock, C., Saad, S. (2015). Fetal programming of chronic kidney disease: The role of maternal smoking, mitochondrial dysfunction, and epigenetic modfification. American Journal of Physiology: Renal Physiology, 308(11), F1189-F1196. [More Information]
  • Glastras, S., Wong, M., Chen, H., Zhang, J., Zaky, A., Pollock, C., Saad, S. (2015). FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity. Nutrition and Metabolism, 12(1), 1-13. [More Information]
  • Wong, M., Wanner, C., Knight, J., Perkovic, V. (2015). Lowering cholesterol in chronic kidney disease: is it safe and effective? European Heart Journal, 36(43), 2988-2995. [More Information]
  • Wong, M., Pollock, C., Cooper, B., Branley, P., Collins, J., Craig, J., Kesselhut, J., Luxton, G., Pilmore, A., Harris, D., et al (2014). Association between GFR Estimated by Multiple Methods at Dialysis Commencement and Patient Survival. Clinical Journal of the American Society of Nephrology, 9(1), 135-142. [More Information]
  • Wong, M., Pollock, C. (2014). Biomarkers in kidney fibrosis: Are they useful? Kidney International Supplements, 4(1), 79-83. [More Information]
  • Knight, J., Wong, M., Perkovic, V. (2014). Optimal targets for blood pressure control in chronic kidney disease: the debate continues. Current Opinion In Nephrology And Hypertension, 23(6), 541-546. [More Information]
  • Wong, M., Saad, S., Zhang, J., Gross, S., Jarolimek, W., Schilter, H., Chen, J., Gill, A., Pollock, C., Wong, M. (2014). Semicarbazide-sensitive amine oxidase (SSAO) inhibition ameliorates kidney fibrosis in a unilateral ureteral obstruction murine model. AJP: Renal Physiology (Online), 307(8), F908-F916. [More Information]
  • Al-Odat, I., Chen, H., Chan, Y., Amgad, S., Wong, M., Gill, A., Pollock, C., Saad, S. (2014). The Impact of Maternal Cigarette Smoke Exposure in a Rodent Model on Renal Development in the Offspring. PloS One, 9(7), 1-10. [More Information]
  • Wong, M., Perkovic, V., Woodward, M., Chalmers, J., Li, Q., Hillis, G., Azari, E., Jun, M., Poulter, N., Hamet, P., Neal, B., Pollock, C., et al (2013). Circulating bone morphogenetic protein-7 and transforming growth factor-(beta)1 are better predictors of renal end points in patients with type 2 diabetes mellitus. Kidney International, 83(2), 278-284. [More Information]
  • Saad, S., Zhang, J., Yong, R., Yaghobian, D., Wong, M., Kelly, D., Chen, X., Pollock, C. (2013). Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells. Diabetologia, 56(5), 1174-1182. [More Information]
  • Wong, M., Saad, S., Pollock, C., Wong, M. (2013). Semicarbazide-sensitive amine oxidase and kidney disease. American Journal of Physiology: Renal Physiology, 305(12), F1637-F1644. [More Information]
  • Johnson, D., Wong, M., Cooper, B., Branley, P., Bulfone, L., Collins, J., Craig, J., Fraenkel, M., Harris, A., Kesselhut, J., Tiller, D., Harris, D., Pollock, C., et al (2012). Effect of timing of dialysis commencement on clinical outcomes of patients with planned initiation of peritoneal dialysis in the ideal trial. Peritoneal Dialysis International, 32(6), 595-604. [More Information]
  • Wong, M., Panchapakesan, U., Qi, W., Silva, D., Chen, X., Pollock, C. (2011). Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-B1. American Journal of Physiology: Renal Physiology, 301(1), F84-F93. [More Information]
  • Amarasekara, C., Uppal, T., Wong, M. (2011). Post partum flare in a patient with hereditary angioedema. Sri Lanka Journal of Obstetrics and Gynaecology, 33(4), 166-167.
  • McGregor, A., Ogwu, C., Uppal, T., Wong, M. (2011). Spontaneous subcutaneous emphysema and pneumomediastinum during second stage of labour. BMJ Case Reports. [More Information]
  • Wong, M., Suzuki, Y., Tanifuji, C., Akiba, H., Okumura, K., Sugaya, T., Yamamoto, T., Horikoshi, S., Tan, S., Pollock, C., et al (2008). Peritubular Ischemia Contributes More to Tubular Damage than Proteinuria in Immune-Mediated Glomerulonephritis. Journal of the American Society of Nephrology, 19(2), 290-297. [More Information]

2017

  • Glastras, S., Chen, H., Tsang, M., Teh, R., McGrath, R., Zaky, A., Chen, J., Wong, M., Pollock, C., Saad, S. (2017). The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet. PloS One, 12(2), 1-17. [More Information]

2016

  • Gallagher, M., Wong, M., Perkovic, V. (2016). ALTITUDE: defining a ceiling for blockade of the renin-angiotensin system? The Lancet Diabetes & Endocrinology, 4(4), 289-290. [More Information]
  • Sukkar, L., Hong, D., Wong, M., Badve, S., Rogers, K., Perkovic, V., Walsh, M., Yu, X., Hillis, G., Gallagher, M., Jardine, M. (2016). Effects of ischaemic conditioning on major clinical outcomes in people undergoing invasive procedures: systematic review and meta-analysis. BMJ, 355, 1-10. [More Information]
  • Liyanage, T., Ninomiya, T., Wang, Y., Neal, B., Jun, M., Wong, M., Jardine, M., Hillis, G., Perkovic, V. (2016). Effects of the mediterranean diet on cardiovascular outcomes-a systematic review and meta-analysis. PloS One, 11(8), 1-11. [More Information]
  • Wong, M., Perkovic, V. (2016). Knowing what we do not know: statin therapy in advanced chronic kidney disease. The Lancet Diabetes & Endocrinology, 4(10), 801-803. [More Information]
  • Wong, M., Perkovic, V., Chalmers, J., Woodward, M., Li, Q., Cooper, M., Hamet, P., Harrap, S., Heller, S., MacMahon, S., Neal, B., Rodgers, A., Zoungas, S., et al (2016). Long-term Benefits of Intensive Glucose Control for Preventing End-Stage Kidney Disease: ADVANCE-ON. Diabetes Care, 39(5), 694-700. [More Information]
  • Glastras, S., Chen, H., Teh, R., McGrath, R., Chen, J., Pollock, C., Wong, M., Saad, S. (2016). Mouse models of diabetes, obesity and related kidney disease. PloS One, 11(8), 1-15. [More Information]

2015

  • Stangenberg, S., Chen, H., Wong, M., Pollock, C., Saad, S. (2015). Fetal programming of chronic kidney disease: The role of maternal smoking, mitochondrial dysfunction, and epigenetic modfification. American Journal of Physiology: Renal Physiology, 308(11), F1189-F1196. [More Information]
  • Glastras, S., Wong, M., Chen, H., Zhang, J., Zaky, A., Pollock, C., Saad, S. (2015). FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity. Nutrition and Metabolism, 12(1), 1-13. [More Information]
  • Wong, M., Wanner, C., Knight, J., Perkovic, V. (2015). Lowering cholesterol in chronic kidney disease: is it safe and effective? European Heart Journal, 36(43), 2988-2995. [More Information]

2014

  • Wong, M., Pollock, C., Cooper, B., Branley, P., Collins, J., Craig, J., Kesselhut, J., Luxton, G., Pilmore, A., Harris, D., et al (2014). Association between GFR Estimated by Multiple Methods at Dialysis Commencement and Patient Survival. Clinical Journal of the American Society of Nephrology, 9(1), 135-142. [More Information]
  • Wong, M., Pollock, C. (2014). Biomarkers in kidney fibrosis: Are they useful? Kidney International Supplements, 4(1), 79-83. [More Information]
  • Knight, J., Wong, M., Perkovic, V. (2014). Optimal targets for blood pressure control in chronic kidney disease: the debate continues. Current Opinion In Nephrology And Hypertension, 23(6), 541-546. [More Information]
  • Wong, M., Saad, S., Zhang, J., Gross, S., Jarolimek, W., Schilter, H., Chen, J., Gill, A., Pollock, C., Wong, M. (2014). Semicarbazide-sensitive amine oxidase (SSAO) inhibition ameliorates kidney fibrosis in a unilateral ureteral obstruction murine model. AJP: Renal Physiology (Online), 307(8), F908-F916. [More Information]
  • Al-Odat, I., Chen, H., Chan, Y., Amgad, S., Wong, M., Gill, A., Pollock, C., Saad, S. (2014). The Impact of Maternal Cigarette Smoke Exposure in a Rodent Model on Renal Development in the Offspring. PloS One, 9(7), 1-10. [More Information]

2013

  • Wong, M., Perkovic, V., Woodward, M., Chalmers, J., Li, Q., Hillis, G., Azari, E., Jun, M., Poulter, N., Hamet, P., Neal, B., Pollock, C., et al (2013). Circulating bone morphogenetic protein-7 and transforming growth factor-(beta)1 are better predictors of renal end points in patients with type 2 diabetes mellitus. Kidney International, 83(2), 278-284. [More Information]
  • Saad, S., Zhang, J., Yong, R., Yaghobian, D., Wong, M., Kelly, D., Chen, X., Pollock, C. (2013). Role of the EGF receptor in PPARgamma-mediated sodium and water transport in human proximal tubule cells. Diabetologia, 56(5), 1174-1182. [More Information]
  • Wong, M., Saad, S., Pollock, C., Wong, M. (2013). Semicarbazide-sensitive amine oxidase and kidney disease. American Journal of Physiology: Renal Physiology, 305(12), F1637-F1644. [More Information]

2012

  • Johnson, D., Wong, M., Cooper, B., Branley, P., Bulfone, L., Collins, J., Craig, J., Fraenkel, M., Harris, A., Kesselhut, J., Tiller, D., Harris, D., Pollock, C., et al (2012). Effect of timing of dialysis commencement on clinical outcomes of patients with planned initiation of peritoneal dialysis in the ideal trial. Peritoneal Dialysis International, 32(6), 595-604. [More Information]

2011

  • Wong, M., Panchapakesan, U., Qi, W., Silva, D., Chen, X., Pollock, C. (2011). Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-B1. American Journal of Physiology: Renal Physiology, 301(1), F84-F93. [More Information]
  • Amarasekara, C., Uppal, T., Wong, M. (2011). Post partum flare in a patient with hereditary angioedema. Sri Lanka Journal of Obstetrics and Gynaecology, 33(4), 166-167.
  • McGregor, A., Ogwu, C., Uppal, T., Wong, M. (2011). Spontaneous subcutaneous emphysema and pneumomediastinum during second stage of labour. BMJ Case Reports. [More Information]

2008

  • Wong, M., Suzuki, Y., Tanifuji, C., Akiba, H., Okumura, K., Sugaya, T., Yamamoto, T., Horikoshi, S., Tan, S., Pollock, C., et al (2008). Peritubular Ischemia Contributes More to Tubular Damage than Proteinuria in Immune-Mediated Glomerulonephritis. Journal of the American Society of Nephrology, 19(2), 290-297. [More Information]

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