Dr Najla Nasr

Senior Lecturer, Senior Research Fellow, the Westmead Institute for Medical Research, Westmead

Telephone 02 8627 3622

Website Honours at Westmead

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Current projects

More than 30 years after its discovery, human immunodeficiency virus-1 (HIV) still propagates worldwide and as of 2016, 36.7 million individuals are living with HIV. Although the advent of antiretroviral therapy has meant HIV can be managed as a chronic disease, there is currently no effective vaccine or microbicide that can block the sexual transmission of HIV.

A fascinating future for HIV research lies ahead as the HIV scientific community focuses on the two major aims of preventing HIV infection through vaccine/microbicide development and curing or eliminating HIV from antiretroviral-controlled chronically infected people.

Ou group is interested in understanding how HIV interacts with innate immune cells and then manipulates them in order to facilitate successful transmission.

In the media

Selected grants

2018

  • Development of gene therapy to prevent HIV inhibition of interferon production in human macrophages and dendritic cells´┐Ż; Cunningham A, Nasr N; Australian Centre for HIV and Hepatitis Virology Research (ACH2)/HIV and Hepatitis C Virology and Immunology Research Grants.

2016

  • Restoring interferon production by myeloid cells infected with HIV by gene therapy; Cunningham A, Harman A, Diefenbach R, Nasr N, Kizana E; Australian Centre for HIV and Hepatitis Virology Research (ACH2)/Research Support.
  • Defining the Interaction of HIV with the Interferon System in Initial Mucosal Infection; Cunningham A, Harman A, Palmer S, Nasr N, Diefenbach R, Sandgren K; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • The Role of Dendritic Cells in Sexual Transmission of HIV and Viral Reservoir Formation; Harman A, Cunningham A, Palmer S, Kim M, Nasr N; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Development of small molecule inhibitors of HIV envelope-Langerin interactions and of HIV uptake by Langerhans Cells (LCs) as topical (genital) microbicides; Cunningham A, Nasr N, Diefenbach R; Australian Centre for HIV and Hepatitis Virology Research/Research Grant.

Selected publications

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Book Chapters

  • Nasr, N., Harman, A., Turville, S., Cunningham, A. (2014). HIV infection of dendritic cells. In Elisa Vincenzi, Guido Poli (Eds.), Human Retroviruses: Method and Protocols, (pp. 221-232). New York: Humana Press. [More Information]
  • Cunningham, A., Harman, A., Kim, M., Nasr, N., Lai, J. (2013). Immunobiology of Dendritic Cells and the Influence of HIV Infection. In Li Wu, Olivier Schwartz (Eds.), HIV Interactions with Dendritic Cells: Infection and Immunity, (pp. 1-44). New York, USA: Springer Science+Business Media. [More Information]

Journals

  • Botting, R., Rana, H., Bertram, K., Rhodes, J., Baharlou, H., Nasr, N., Cunningham, A., Harman, A. (2017). Langerhans cells and sexual transmission of HIV and HSV. Reviews in Medical Virology, 27(2), e1923. [More Information]
  • Nasr, N., Alshehri, A., Wright, T., Shahid, M., Heiner, B., Harman, A., Botting, R., Helbig, K., Beard, M., Suzuki, K., Cunningham, A., et al (2017). Mechanism of interferon-stimulated gene induction in HIV-1- infected macrophages. Journal of Virology, 91(20), 1-19. [More Information]
  • Ng, W., Londrigan, S., Nasr, N., Cunningham, A., Turville, S., Brooks, A., Reading, P. (2016). The C-type lectin langerin functions as a receptor for attachment and infectious entry of influenza A virus. Journal of Virology, 90(1), 206-221. [More Information]
  • Marsden, V., Donaghy, H., Bertram, K., Harman, A., Nasr, N., Keoshkerian, E., Merten, S., Lloyd, A., Cunningham, A. (2015). Herpes Simplex Virus Type 2-Infected Dendritic Cells Produce TNF-a, Which Enhances CCR5 Expression and Stimulates HIV Production from Adjacent Infected Cells. Journal of Immunology, 194(9), 4438-4445. [More Information]
  • Harman, A., Nasr, N., Feetham, A., Galoyan, A., Alshehri,, A., Rambukwelle, D., Botting, R., Hiener, B., Diefenbach, E., Diefenbach, R., Kim, M., Cunningham, A., et al (2015). HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1. Journal of Virology, 89(13), 6575-6584. [More Information]
  • Kim, M., Truong, N., James, V., Bosnjak, L., Sandgren, K., Harman, A., Nasr, N., Bertram, K., Olbourne, N., Sawleshwarkar, S., Cunningham, A., et al (2015). Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. PLoS Pathogens, 11(4), 1-19. [More Information]
  • Nasr, N., Lai, J., Botting, R., Mercier, S., Harman, A., Kim, M., Turville, S., Center, R., Domagala, T., Gorry, P., Cunningham, A., et al (2014). Inhibition of Two Temporal Phases of HIV-1 Transfer from Primary Langerhans Cells to T Cells: The Role of Langerin. Journal of Immunology, 193(5), 2554-2564. [More Information]
  • Harman, A., Bye, C., Nasr, N., Sandgren, K., Kim, M., Mercier, S., Botting, R., Lewin, S., Cunningham, A., Cameron, P. (2013). Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells. Journal of Immunology, 190(1), 66-79. [More Information]
  • Cunningham, A., Harman, A., Nasr, N. (2013). Initial HIV mucosal infection and dendritic cells. EMBO Molecular Medicine, 5(5), 658-660. [More Information]
  • Mercier, S., Donaghy, H., Botting, R., Turville, S., Harman, A., Nasr, N., Ji, H., Kusebauch, U., Mendoza, L., Shteynberg, D., Cunningham, A., et al (2013). The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes. PLoS Pathogens, 9(10), 1-18. [More Information]
  • Harman, A., Kim, M., Nasr, N., Sandgren, K., Cameron, P. (2013). Tissue dendritic cells as portals for HIV entry. Reviews in Medical Virology, 23(5), 319-333. [More Information]
  • Nasr, N., Maddocks, S., Turville, S., Harman, A., Woolger, N., Helbig, K., Wilkinson, J., Bye, C., Wright, T., Rambukwelle, D., Donaghy, H., Cunningham, A., et al (2012). HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood, 120(4), 778-788. [More Information]
  • Harman, A., Lai, J., Turville, S., Samarajiwa, S., Gray, L., Marsden, V., Mercier, S., Jones, K., Nasr, N., Rustagi, A., Cunningham, A., et al (2011). HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production. Blood, 118(2), 298-308. [More Information]
  • Huch, J., Cunningham, A., Arvin, A., Nasr, N., Santegoets, S., Slobedman, E., Slobedman, B., Abendroth, A. (2010). Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection. Journal of Virology, 84(8), 4060-4072. [More Information]
  • Cunningham, A., Abendroth, A., Jones, C., Nasr, N., Turville, S. (2010). Viruses and Langerhans cells. Immunology and Cell Biology, 88(4), 416-423. [More Information]
  • Harman, A., Kraus, M., Bye, C., Byth Wilson, K., Turville, S., Tang, O., Mercier, S., Nasr, N., Stern, J., Slobedman, B., Cunningham, A., et al (2009). HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood, 114(1), 85-94. [More Information]
  • Gray, L., Sterjovski, J., Churchill, M., Ellery, P., Nasr, N., Lewin, S., Crowe, S., Wesselingh, S., Cunningham, A., Gorry, P. (2005). Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome. Virology, 337(2), 384-398. [More Information]
  • Ewart, G., Nasr, N., Naif, H., Cox, G., Cunningham, A., Gage, P. (2004). Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication In Cultured Human Macrophages. Antimicrobial Agents and Chemotherapy, 48(6), 2325-2330. [More Information]
  • Naif, H., Cunningham, A., Alali, M., Nasr, N., Buhler, M., Stewart, G., Li, S., Schols, D., de Clercq, E. (2002). A Human Immunodeficiency Virus Type 1 Isolate from an Infected Person Homozygous for CCR5/\32 Exhibits Dual Tropism by Infecting Macrophages and MT2 Cells via CXCR4. Journal of Virology, 76(7), 3114-3124. [More Information]
  • Qi, J., Stevens, R., Wadley, R., Collins, A., Cooley, M., Naif, H., Nasr, N., Cunningham, A., Katsoulotos, G., Wanigasekara-Mohotti, Y., Roufogalis, B., et al (2002). IL-16 Regulation of Human Mast Cells/Basophils and Their Susceptability to HIV-1. Journal of Immunology, 168(8), 4127-4134.

2017

  • Botting, R., Rana, H., Bertram, K., Rhodes, J., Baharlou, H., Nasr, N., Cunningham, A., Harman, A. (2017). Langerhans cells and sexual transmission of HIV and HSV. Reviews in Medical Virology, 27(2), e1923. [More Information]
  • Nasr, N., Alshehri, A., Wright, T., Shahid, M., Heiner, B., Harman, A., Botting, R., Helbig, K., Beard, M., Suzuki, K., Cunningham, A., et al (2017). Mechanism of interferon-stimulated gene induction in HIV-1- infected macrophages. Journal of Virology, 91(20), 1-19. [More Information]

2016

  • Ng, W., Londrigan, S., Nasr, N., Cunningham, A., Turville, S., Brooks, A., Reading, P. (2016). The C-type lectin langerin functions as a receptor for attachment and infectious entry of influenza A virus. Journal of Virology, 90(1), 206-221. [More Information]

2015

  • Marsden, V., Donaghy, H., Bertram, K., Harman, A., Nasr, N., Keoshkerian, E., Merten, S., Lloyd, A., Cunningham, A. (2015). Herpes Simplex Virus Type 2-Infected Dendritic Cells Produce TNF-a, Which Enhances CCR5 Expression and Stimulates HIV Production from Adjacent Infected Cells. Journal of Immunology, 194(9), 4438-4445. [More Information]
  • Harman, A., Nasr, N., Feetham, A., Galoyan, A., Alshehri,, A., Rambukwelle, D., Botting, R., Hiener, B., Diefenbach, E., Diefenbach, R., Kim, M., Cunningham, A., et al (2015). HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1. Journal of Virology, 89(13), 6575-6584. [More Information]
  • Kim, M., Truong, N., James, V., Bosnjak, L., Sandgren, K., Harman, A., Nasr, N., Bertram, K., Olbourne, N., Sawleshwarkar, S., Cunningham, A., et al (2015). Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. PLoS Pathogens, 11(4), 1-19. [More Information]

2014

  • Nasr, N., Harman, A., Turville, S., Cunningham, A. (2014). HIV infection of dendritic cells. In Elisa Vincenzi, Guido Poli (Eds.), Human Retroviruses: Method and Protocols, (pp. 221-232). New York: Humana Press. [More Information]
  • Nasr, N., Lai, J., Botting, R., Mercier, S., Harman, A., Kim, M., Turville, S., Center, R., Domagala, T., Gorry, P., Cunningham, A., et al (2014). Inhibition of Two Temporal Phases of HIV-1 Transfer from Primary Langerhans Cells to T Cells: The Role of Langerin. Journal of Immunology, 193(5), 2554-2564. [More Information]

2013

  • Harman, A., Bye, C., Nasr, N., Sandgren, K., Kim, M., Mercier, S., Botting, R., Lewin, S., Cunningham, A., Cameron, P. (2013). Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells. Journal of Immunology, 190(1), 66-79. [More Information]
  • Cunningham, A., Harman, A., Kim, M., Nasr, N., Lai, J. (2013). Immunobiology of Dendritic Cells and the Influence of HIV Infection. In Li Wu, Olivier Schwartz (Eds.), HIV Interactions with Dendritic Cells: Infection and Immunity, (pp. 1-44). New York, USA: Springer Science+Business Media. [More Information]
  • Cunningham, A., Harman, A., Nasr, N. (2013). Initial HIV mucosal infection and dendritic cells. EMBO Molecular Medicine, 5(5), 658-660. [More Information]
  • Mercier, S., Donaghy, H., Botting, R., Turville, S., Harman, A., Nasr, N., Ji, H., Kusebauch, U., Mendoza, L., Shteynberg, D., Cunningham, A., et al (2013). The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes. PLoS Pathogens, 9(10), 1-18. [More Information]
  • Harman, A., Kim, M., Nasr, N., Sandgren, K., Cameron, P. (2013). Tissue dendritic cells as portals for HIV entry. Reviews in Medical Virology, 23(5), 319-333. [More Information]

2012

  • Nasr, N., Maddocks, S., Turville, S., Harman, A., Woolger, N., Helbig, K., Wilkinson, J., Bye, C., Wright, T., Rambukwelle, D., Donaghy, H., Cunningham, A., et al (2012). HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood, 120(4), 778-788. [More Information]

2011

  • Harman, A., Lai, J., Turville, S., Samarajiwa, S., Gray, L., Marsden, V., Mercier, S., Jones, K., Nasr, N., Rustagi, A., Cunningham, A., et al (2011). HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production. Blood, 118(2), 298-308. [More Information]

2010

  • Huch, J., Cunningham, A., Arvin, A., Nasr, N., Santegoets, S., Slobedman, E., Slobedman, B., Abendroth, A. (2010). Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection. Journal of Virology, 84(8), 4060-4072. [More Information]
  • Cunningham, A., Abendroth, A., Jones, C., Nasr, N., Turville, S. (2010). Viruses and Langerhans cells. Immunology and Cell Biology, 88(4), 416-423. [More Information]

2009

  • Harman, A., Kraus, M., Bye, C., Byth Wilson, K., Turville, S., Tang, O., Mercier, S., Nasr, N., Stern, J., Slobedman, B., Cunningham, A., et al (2009). HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood, 114(1), 85-94. [More Information]

2005

  • Gray, L., Sterjovski, J., Churchill, M., Ellery, P., Nasr, N., Lewin, S., Crowe, S., Wesselingh, S., Cunningham, A., Gorry, P. (2005). Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome. Virology, 337(2), 384-398. [More Information]

2004

  • Ewart, G., Nasr, N., Naif, H., Cox, G., Cunningham, A., Gage, P. (2004). Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication In Cultured Human Macrophages. Antimicrobial Agents and Chemotherapy, 48(6), 2325-2330. [More Information]

2002

  • Naif, H., Cunningham, A., Alali, M., Nasr, N., Buhler, M., Stewart, G., Li, S., Schols, D., de Clercq, E. (2002). A Human Immunodeficiency Virus Type 1 Isolate from an Infected Person Homozygous for CCR5/\32 Exhibits Dual Tropism by Infecting Macrophages and MT2 Cells via CXCR4. Journal of Virology, 76(7), 3114-3124. [More Information]
  • Qi, J., Stevens, R., Wadley, R., Collins, A., Cooley, M., Naif, H., Nasr, N., Cunningham, A., Katsoulotos, G., Wanigasekara-Mohotti, Y., Roufogalis, B., et al (2002). IL-16 Regulation of Human Mast Cells/Basophils and Their Susceptability to HIV-1. Journal of Immunology, 168(8), 4127-4134.

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