Dr Nicholas Shackel

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Themes | Research interests | Grants | PhD & Masters' project opportunities | Honours project opportunities | Keywords

Themes

Cancer; Infection and Immunological Conditions; Chronic disease and ageing

Research interests

To understand the molecular mechanisms regulating liver fibrosis aiming to developed novel therapeutic agents as well as developing new diagnostic investigations.

Current national competitive grants*

2010

The role of the hepatocyte hedgehog pathway in progressive liver injury
McCaughan G, Shackel N, Warner F
NHMRC Project Grant ($550,500 over 3 years)

* Grants administered through the University of Sydney

PhD and Masters' project opportunities

The Role of Extracellular Matrix Metalloprotease Inducer (EMMPRIN) in Liver Disease
Stem Cells in Liver Disease

Honours project opportunities

Role of Bone-Marrow Derived Cells in Progressive Liver Injury and Carcinogenesis
The role of Cyclophilin and Extracellular Matrix Metalloproteinase (EMMPRIN) interactions in liver injury.
The role of Extracellular Matrix Metalloproteinase (EMMPRIN) binding partners in the development of human liver injury
The functional characterisation of the RERE gene in Hepatitis C infected human hepatocytes
The role of the novel pathway of Extracellular Matrix Metalloproteinase (EMMPRIN) mediated cell aggregation in the development of human liver injury and liver cancer.
Glycosylation of Extracellular Matrix Metalloproteinase (EMMPRIN) in human liver disease

Keywords

Liver Disease; Hepatitis; Cell biology; Stem cells; Fibrosis

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