Dr Shackel is a clinical scientist with an established tract record in academia being the recipient of multiple awards including a NHMRC Gustav-Nossal Scholarship and a NHMRC C. J. Martin Fellowship. Dr Shackel has authored 36 publications (23 as first or last author, H factor, 12) and 4 book chapters. These have consistently been at a high academic level and resulted in 679 citations (five of these manuscripts have 164, 100, 52 and 37 citations respectively). [More...]

Dr Shackel is a clinical scientist with an established tract record in academia being the recipient of multiple awards including a NHMRC Gustav-Nossal Scholarship and a NHMRC C. J. Martin Fellowship. Dr Shackel has authored 36 publications (23 as first or last author, H factor, 12) and 4 book chapters. These have consistently been at a high academic level and resulted in 679 citations (five of these manuscripts have 164, 100, 52 and 37 citations respectively).

Dr Shackel pioneered the use of functional genomics methods to study human liver. Dr Shackel’s academic output to-date has resulted in a number of significant novel findings including:

1. Identification of a Th1 immune phenotype in HCV liver injury

2. Identification of increased WNT pathway gene expression in biliary liver disease

3. Identification of the collagen receptor DDR1 on human hepatocytes and its increased expression in human cirrhosis

4. Identification of increased RERE expression and trans-alternate splicing in HCV cirrhosis

5. Identification of EMMPRIN in human cirrhosis (funded in NHMRC project grant 512283)

6. The initial description of the Hh pathway in human liver disease (funded in NHMRC project grant 632701)

Dr Shackel’s academic output is further evidenced by the 79 abstracts accepted at national and international meetings, with 19 of these being accepted at international meetings including 11 oral presentations overseas of which one was a plenary session at AASLD and another at APASL. Dr Shackel has been awarded a number of prizes overseas for research excellence including the 1st Poster Prize at the 2002 Basel Liver Week, an American Australian Association Keith Murdoch Award in 2002, an American Liver Foundation Post-Doctoral Fellowship in 2003 and poster prize at the 2007 Australian Gastroenterology Week.

Current Appointments:

• Staff Specialist in Gastroenterology Royal Prince Alfred Hospital Camperdown, Sydney

• Head of Genomic Medicine and Research Officer, Centenary Institute, Sydney

• Senior Lecturer, The University of Sydney (Conjoint appointment)

o Teaching: Senior Lecturer, Department of Medicine University of Sydney

o Lectures to Medical Students, University of Sydney.

• Supervision of Students and Staff: 2 RA, 5 Honours student and 6 PhD students (4 Honors students supervised by Dr Shackel in the period from 2007-2011 have all been awarded the University Medal – all Honours students under Dr Shackel have been awarded independently funded PhD scholarships)

Membership, Committees, Societies, Education and Professional Duties:

• American Association for the Study of Liver Disease

• Australian Society of Medical Research

• Gastroenterology Society of Australia

• Grant reviewer: NHMRC 2005 and NHMRC Review Panel 2006-2008

• Journal Reviewer: Gastroenterology, PLosOne, Hepatology, GUT, American Journal of Transplantation, Liver Transplantation, Australian New Zealand Journal of Medicine and Journal of Gastroenterology and Hepatology

• Chair person and scientific organizer 5th Australian Meeting on Hepatitis C

• Conference organizer TSANZ Annual Meeting Canberra June 2010

Career Highlights:

1988 BSc University Medal Physiology and Pharmacology

1991 MB BS (Hons) (part of a combined BSc MB BS)

1997 NHMRC Gustav-Nossal Postgraduate Research Scholarship

1998 FRACP

1998 ASMR Campion-Ma-Playoust Memorial Award

2001 PhD Centenary Institute of Cancer Medicine and Cell Biology

2002 NHMRC C. J. Martin Fellow Liver Laboratory of Prof. Rockey Duke University USA

2002 American Australian Association Keith Murdoch Award

2003 American Liver Foundation Post-Doctoral Fellowship

2005 Staff Specialist Physician in Gastroenterology, Hepatology and Transplantation

2008 CIA Project Grant 512283 studying EMMPRIN in Liver Disease

2010 CIB Project Grant 632701 studying The Hedgehog Pathway in Liver Disease

2010 Organizer TSANZ Annual Meeting Canberra June 2010

2011 Appointed Head of Genomic Medicine at Centenary Institute [Hide detail]