Associate Professor Nicholas Shackel

Associate Professor
Medicine, Central Clinical School
A W Morrow Gastroenterology and Liver Centre

C39 - Royal Prince Alfred Hospital
The University of Sydney
NSW 2006 Australia

T: +61 2 9565 6286
F: +61 2 9565 6101
Curriculum vitae

Biographical details

Dr Shackel is a clinical scientist with an established tract record in academia being the recipient of multiple awards including a NHMRC Gustav-Nossal Scholarship and a NHMRC C. J. Martin Fellowship. Dr Shackel has authored 36 publications (23 as first or last author, H factor, 12) and 4 book chapters. These have consistently been at a high academic level and resulted in 679 citations (five of these manuscripts have 164, 100, 52 and 37 citations respectively). [More...]

Research interests

To understand the molecular mechanisms regulating liver fibrosis aiming to developed novel therapeutic agents as well as developing new diagnostic investigations.

The current focus of the research group is to further understand the role of the glycoprotein CD147 in mediating basic and fundamental aspects of tissue inflammatory responses and carcinogenesis. Our group has made the fundamental discovery that CD147 mediates a process of inflammatory cell aggregation, which was previously not recognised, that mediates inflammatory responses and carcinogenesis. Taking this novel discovery from the bench through to high impact papers is the current focus of the group.