Associate Professor Nicholas Shackel
C39 - Royal Prince Alfred Hospital
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Dr Shackel is a clinical scientist with an established tract record in academia being the recipient of multiple awards including a NHMRC Gustav-Nossal Scholarship and a NHMRC C. J. Martin Fellowship. Dr Shackel has authored 36 publications (23 as first or last author, H factor, 12) and 4 book chapters. These have consistently been at a high academic level and resulted in 679 citations (five of these manuscripts have 164, 100, 52 and 37 citations respectively). [More...]
Dr Shackel is a clinical scientist with an established tract record in academia being the recipient of multiple awards including a NHMRC Gustav-Nossal Scholarship and a NHMRC C. J. Martin Fellowship. Dr Shackel has authored 36 publications (23 as first or last author, H factor, 12) and 4 book chapters. These have consistently been at a high academic level and resulted in 679 citations (five of these manuscripts have 164, 100, 52 and 37 citations respectively).
Dr Shackel pioneered the use of functional genomics methods to study human liver. Dr Shackels academic output to-date has resulted in a number of significant novel findings including:
1. Identification of a Th1 immune phenotype in HCV liver injury
2. Identification of increased WNT pathway gene expression in biliary liver disease
3. Identification of the collagen receptor DDR1 on human hepatocytes and its increased expression in human cirrhosis
4. Identification of increased RERE expression and trans-alternate splicing in HCV cirrhosis
5. Identification of EMMPRIN in human cirrhosis (funded in NHMRC project grant 512283)
6. The initial description of the Hh pathway in human liver disease (funded in NHMRC project grant 632701)
Dr Shackels academic output is further evidenced by the 79 abstracts accepted at national and international meetings, with 19 of these being accepted at international meetings including 11 oral presentations overseas of which one was a plenary session at AASLD and another at APASL. Dr Shackel has been awarded a number of prizes overseas for research excellence including the 1st Poster Prize at the 2002 Basel Liver Week, an American Australian Association Keith Murdoch Award in 2002, an American Liver Foundation Post-Doctoral Fellowship in 2003 and poster prize at the 2007 Australian Gastroenterology Week.
Staff Specialist in Gastroenterology Royal Prince Alfred Hospital Camperdown, Sydney
Head of Genomic Medicine and Research Officer, Centenary Institute, Sydney
Senior Lecturer, The University of Sydney (Conjoint appointment)
o Teaching: Senior Lecturer, Department of Medicine University of Sydney
o Lectures to Medical Students, University of Sydney.
Supervision of Students and Staff: 2 RA, 5 Honours student and 6 PhD students (4 Honors students supervised by Dr Shackel in the period from 2007-2011 have all been awarded the University Medal all Honours students under Dr Shackel have been awarded independently funded PhD scholarships)
Membership, Committees, Societies, Education and Professional Duties:
American Association for the Study of Liver Disease
Australian Society of Medical Research
Gastroenterology Society of Australia
Grant reviewer: NHMRC 2005 and NHMRC Review Panel 2006-2008
Journal Reviewer: Gastroenterology, PLosOne, Hepatology, GUT, American Journal of Transplantation, Liver Transplantation, Australian New Zealand Journal of Medicine and Journal of Gastroenterology and Hepatology
Chair person and scientific organizer 5th Australian Meeting on Hepatitis C
Conference organizer TSANZ Annual Meeting Canberra June 2010
1988 BSc University Medal Physiology and Pharmacology
1991 MB BS (Hons) (part of a combined BSc MB BS)
1997 NHMRC Gustav-Nossal Postgraduate Research Scholarship
1998 ASMR Campion-Ma-Playoust Memorial Award
2001 PhD Centenary Institute of Cancer Medicine and Cell Biology
2002 NHMRC C. J. Martin Fellow Liver Laboratory of Prof. Rockey Duke University USA
2002 American Australian Association Keith Murdoch Award
2003 American Liver Foundation Post-Doctoral Fellowship
2005 Staff Specialist Physician in Gastroenterology, Hepatology and Transplantation
2008 CIA Project Grant 512283 studying EMMPRIN in Liver Disease
2010 CIB Project Grant 632701 studying The Hedgehog Pathway in Liver Disease
2010 Organizer TSANZ Annual Meeting Canberra June 2010
2011 Appointed Head of Genomic Medicine at Centenary Institute [Hide detail]
To understand the molecular mechanisms regulating liver fibrosis aiming to developed novel therapeutic agents as well as developing new diagnostic investigations.
The current focus of the research group is to further understand the role of the glycoprotein CD147 in mediating basic and fundamental aspects of tissue inflammatory responses and carcinogenesis. Our group has made the fundamental discovery that CD147 mediates a process of inflammatory cell aggregation, which was previously not recognised, that mediates inflammatory responses and carcinogenesis. Taking this novel discovery from the bench through to high impact papers is the current focus of the group.
Honours project opportunities
Hepatocyte subpopulation growth dynamics during liver injury and leading to Hepatocellular Carcinoma
Role of Bone-Marrow Derived Cells in Progressive Liver Injury and Carcinogenesis
The role of hepatocyte matrix metalloproteinases in NASH progression
The role of CD147 mediated cell aggregation in the development of human liver injury and liver cancer.