Professor Nicholas King

Professor of Viral Immunopathology
Pathology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 4553
Fax +61 2 9351 3429

Map

Research interests

We are interested in the neurotropic flavivirus, West Nile virus, and how our immune response, in trying to get rid of virus infection, lethally damages the host nervous system in this response.

We are studying the pathogenesis of West Nile virus encephalitis to understand which components cause lethal damage in the brain and which are crucial for virus clearance. We are also investigating early immune responses to infection in specialised organs and sites, including the brain, the skin, the genitourinary tract, the embryo and the eye, as being the key to modulating this process before damage occurs.

Current research students

Project title Research student
Impact of type 2 diabetes mellitus in protien post translational modifications with iscemia/reperfusion injury and post conditioning. Desmond LI

International links

Germany

(University of Muenster) Collaborative Research into diagnostic imaging approaches to viral encephalitis

Selected grants

2017

  • RES: Groups 5-10 CBA Mice are to be infected with the Pba strain of malaria- with Cour Pharma; King N, Grau G, Niewold P, Cohen A; COUR Pharmaceuticals Development Co. INC/Client Commissioned Research.
  • Mapping dynamic immunity: next generation computational approaches to track the evolution of immune responses in West Nile virus & Zika virus encephalitis; Ashhurst T, Read M, King N, Roehm U, Koprinska I, Scalzo R; Marie Bashir Institute for Infectious Diseases and Biosecurity/Seed Funding Grants.

2016

  • Targetting Monocytes With Microparticles To Prevent Kidney Allograft Rejection; Getts D, Chadban S, King N, Wu H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Novel Insights into the Pathobiology of Alphavirus Infections; Mahalingam S, King N, Smith P, Herrero L; National Health and Medical Research Council (NHMRC)/Project Grants.
  • CyTOF2.1 Upgrade Package to Helios System Capability; King N, Fazekas de St Groth B, Hart D, Booth D, Charles (nee Slaviero) K; University of Sydney/Equipment Grant.
  • Profiling tissue protein, elemental ions and nanoparticle distributions; Witting P, King N; Australian Research Council (ARC)/Discovery Projects (DP).
  • 3D cell explorer; Chrzanowski W, King N, Weiss A, George J, Boddy A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2015

  • Characterising splenic myeloid responses to CNS pathogens; Mitchell A, Grau G, Fazekas de St Groth B, King N, Palendira U; University of Sydney/Internal Scheme.
  • Single molecule science laboratory; King N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Upgrade Suite for Multiphoton Microscopes; Weninger W, King N, Triccas J, Bertolino P, Jolly C; DVC Research/Equipment Grant.
  • AINST Accelerator Scheme - Project Officers Group (working title); Kuncic Z, de Sterke C, King N, Sukkarieh S; DVC Research/AINST Accelerator Scheme.
  • Cell-derived microparticles as novel immune modulators in neurotropic virus infection; King N; DVC Research/Bridging Support Grant.
  • Immune-modifying-particle-induced Tregs induce remission in experimental autoimmune encephalomyelitis; King N, Getts D; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • A CyTOF for the NSW Advanced Cytometry Facility - clean multidimensional multiparametric flow cytometry using single cell mass spectrometry; King N, Campbell I, Fazekas de St Groth B, Cordwell S, Rendina L, Gunning P, Crossley M, Davenport M, Hogg P, Pimanda J, Goldys E, Jin D, Molloy M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Imaging cell and tissue architecture using confocal and super-resolution microscopy; King N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Redox Control of the Immune Regulatory Protein, Indoleamine 2,3-dioxygenase; Thomas S, Witting P, King N; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.
  • A high-throughput, bright-field and fluorescence digital slide scanning platform and service that is both research and teaching-focused and available University-wide.; King N, Graeber M, Naylor M, Slapeta J, Quinnell R, Charles (nee Slaviero) K, Owens T, Bourne R, Braet F, Hambly B, Overall R, Stone J, Twigg S, Hardikar A, Halliday G, Richardson D, Byrne M, Keay K, Marsh D, Howell V, Pollock C, Chen X; DVC Research/Equipment Grant.

2012

  • A five laser multichannel flow cytometry cell sorter for the University of New South Wales as part of an advanced flow cytometry network.; Crossley M, King N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Role of Inflammation in Diabetic Cardiomyopathy; Twigg S, King N, McLennan S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Immune modifying particles - a novel therapeutic strategy to treat West Nile Virus encephalitis; King N, Getts D; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Fluorescence microscopy with optical tweezers: imaging cellular responses; Weninger W, Gunning P, Grau G, King N, Grewal T, Soon L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2010

  • Multiphoton microscope for Cellular Imaging in Live Animals; Leamey C, Phillips W, Dampney R, Westbrook R, Morley J, Arabzadeh E, Dreher B, Solomon S, Protti D, McGregor I, King N, Hunt N, Keay K, Allen D, Koeppl C, Cullen K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Role of monocytes in West Nile Virus encephalitis; King N; DVC Research/Bridging Support Grant.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Oxidative Stress Bioanalytical Facility; Stocker R, Hunt N, Mason R, Witting P, Roufogalis B, Lay P, Tiganis T, Davies M, Dawes I, Drummond G, Geczy C, Kachigian L, Hogg P, Lackmann M, Thomas S, Croft K, King N, Tilley L, James D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Super-resolution fluorescence microscopy; Gaus K, Gandevia S, King N, Allen D, Vadas M, Ammit A, Grewal T, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • 7-laser BD LSR-II and Cellomics Array Scan VTi to Enhance Capability and Throughput for the NSW Advanced Cytometry Facility; King N, Weninger W, Gunning P, Fazekas de St Groth B, Campbell I, Christopherson R, Black J, Mason R, Richardson D, Halliday G, Grau G, Gandevia S, Kachigian L, Geczy C, Jessup W, Vadas M, Britton W, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • A new Laser Microdissection Microscope with a unique pressure catapulting technique allows isolation of pure samples for subsequent downstream molecular analyses; Halliday G, Morris B, Mason R, Murphy C, Bishop A, Leamey C, Joshua D, Lee C, Iland H, Pamphlett R, Richardson D, King N, Hunt N, Arnold J, Morris M, Protti D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The 1st Sino-Australian Symposium: Cancer research in the 21st century - A joint research symposium of the University of Sydney and Shanghai Jiao Tong University; King N; Office of Global Engagement/IPDF Grant.
  • Interaction of anti-viral IDO and NOS2 in vivo in a novel murine STD model; King N, Thomas S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • autoMACS Pro Separator; Abendroth A, Britton W, Richardson D, King N, Halliday G, Pollard J, McMinn P, Bishop A, Triccas J, Wang M, Byrne S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Lipocalin 2 in host defence of the central nervous system; Campbell I, King N, Richardson D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Immunopathological role of monocyte/macrophages in flavivirus encephalitis; King N, Campbell I; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Dako ACIS III Cellular Imaging and Analysis System; King N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • ACISIII Automated Cellular Imaging System with remote diagnostic facility, ACISIII additional workstation; King N; Clive & Vera Ramaciotti Foundation/Equipment Grant.

2007

  • Not known - to be advised; King N; University of Sydney/Internal Research Grant Allocations.
  • Rotor-Gene 6000, 5-Plex HRM with desktop computer & Gene-Disc 100 Stater Kit; Halliday G, Yue D, Sharland A, Bishop A, Stocker R, Bao B, McLennan S, Matsumoto I, Hambly B, Rose B, Harbour C, Ho J, Lee C, Twigg S, Soon L, Richardson D, King N, Zreiqat H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • PHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer research; Halliday G, Ho J, Conigrave A, Iland H, Lee C, Joshua D, Cook D, Richardson D, Reichardt J, Grau G, Lovejoy D, Hunt N, King N, Mason R, Murphy C, Sharland A, Assinder S, Dong Q, Bishop A; Cancer Institute New South Wales/Infrastructure Grant.
  • The Blood-Retinal Barrier - Modelling Mechanisms for Maintenance, Breakdown and Repair; King N, Madigan M, Gillies M, Provis J; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Regulation of MHC-I and ICAM-1 by flavivirus, West Nile; Kesson A, King N; Australian Research Council (ARC)/Discovery Projects (DP).
  • Advanced Imaging Flow Cytometry Facility for NSW; King N, Campbell I, Cook D, Black J, Halliday G, McAvoy J, Gunning P, Pollard J, Murray M, Britton W, Dawes I, Khachigian L, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2005

  • Immunobiology of early pregnancy-a model of virus-induced abortion; King N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • FACS Aria for the University of Sydney Flow Cytometry Facility; King N, Pollard J, Rasko J, Lovicu F, Bishop A, Bertolino P, Briscoe H, Gillies M, Madigan M, McAvoy J, Murphy C, Balcar V, Armour C, Hughes M, Reeve V, Christopherson R, Halliday G, Christie M, Pollock C, McCaughan G, Gorrell M, Dong Q, Abendroth A, Menzies S, Barnetson R, Byrne S, Hunt N, Hambly B, Cook D, Mason R, Day M, Black J; University of Sydney/Equipment Grant.

2004

  • DAKO autostainer-auto-immunohistochemistry instrument; King N; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2003

  • Immunopathogenesis of West Nile virus encephalitis - requirement for interferon-gamma-dependent soluble mediators; King N, Kesson A, Karupiah G, Chaudhri G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • SELDI Protein Chip System; Baxter R, Christopherson R, King N; University of Sydney/Major Equipment Grant.

2002

  • Immunopathogenesis of West Nile virus encephalitis-requirement for interferon-gamma-dependent soluable mediators; King N; University of Sydney/Medicine Bridging.
  • Investigation of the roles of TNF alpha-related apoptosis-inducing ligand, TRAIL, in the immune system; Sedger L, King N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Role of Placental self Marker and Adhesion Molecule Expression in Successful Implantation of the; King N; Watson Munroe Fund/Grant-In-Aid.

2000

  • Modulation of the human blood-retinal barriers and the role of microglia; Penfold P, Provis J, King N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of epidermal langerhans cells in the induction of immunity to arboviruses; King N, Halliday G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Role of nitric oxide in influenza A virus-induced pneumonia; Karupiah G, King N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A virus model to determine the role of MHC and ICAM-1 in successful embryonic implantation; King N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of TNF and IL-1 beta in arbovirus-induced langerhans cell migration from the skin; King N, Halliday G; National Health and Medical Research Council (NHMRC)/Project Grants.

1999

  • Models of Human Viral Disease: Role of nitric oxide and chemokines in the pathogenesis of lethal pne; Karupiah G, King N, Hunt N; University of Sydney/Medical Foundation Program Grant.
  • PTC 225 Tetrad Thermocycler; Karupiah G, King N; Clive & Vera Ramaciotti Foundation/Research Grants.

Selected publications

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Book Chapters

  • King, N., Davison, A., Getts, D., Lu, D., Getts, M., Yeung, A., Peterson, J., Kesson, A. (2009). Enhanced antigen processing or immune evasion? West Nile virus and the induction of immune recognition molecules. In Diamond, Michael S. (Eds.), West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response, (pp. 309-339). New York: Springer.
  • King, N., Shrestha, B., Kesson, A. (2003). Immune modulation by flaviviruses. In Karl Maramorosch,F.A.Murphy,A.J.Shatkin,T.J.Chambers + T.P.Monath (Eds.), The Flaviviruses: Pathogenesis and Immunity, Volume 60 (Advances in Virus Research), (pp. 121-155). New York: Academic Press.

Journals

  • Peterson, J., Kesson, A., King, N. (2017). A model of auto immune response. BMC Immunology, 18(SUPPL 1), 47-65. [More Information]
  • Peterson, J., Kesson, A., King, N. (2017). A theoretical model of the West Nile Virus survival data. BMC Immunology, 18(Suppl 1), 23-38. [More Information]
  • Zimmermann, J., Hafezi, W., Dockhorn, A., Lorentzen, E., Krauthausen, M., Getts, D., Muller, M., Kuhn, J., King, N. (2017). Enhanced viral clearance and reduced leukocyte infiltration in experimental herpes encephalitis after intranasal infection of CXCR3-deficient mice. Journal of Neurovirology, 23(3), 394-403. [More Information]
  • King, N., Teixeira, M., Mahalingam, S. (2017). Zika Virus: Mechanisms of Infection During Pregnancy. Trends in Microbiology, 25(9), 701-702. [More Information]
  • Kashem, M., Sarker, R., Des Etages, H., Machaalani, R., King, N., McGregor, I., Matsumoto, I. (2009). Comparative proteomics in the corpus callosal sub-regions of postmortem human brain. Neurochemistry International, 55(7), 483-490. [More Information]
  • Trian, T., Qi, G., Moir, L., Burgess, J., Kuo, C., King, N., Reddel, H., Black, J., Oliver, B., McParland, B. (2009). Rhinovirus-induced Exacerbations of Asthma - How is the β2-adrenoceptor Implicated? American Journal of Respiratory Cell and Molecular Biology, 43(2), 227-233. [More Information]
  • Quintana, A., Muller, M., Frausto, R., Ramos, R., Getts, D., Sanz, E., Hofer, M., Krathausen, M., King, N., Hildago, J., Campbell, I. (2009). Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enchances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis. The Journal of Immunology, 183(3), 2079-2088. [More Information]
  • Patel, M., Singh, J., Niknami, M., Kurek, C., Yao, M., Lu, S., Maclean, F., King, N., Gelb, M., Scott, K., Dong, Q., et al (2008). Cytosolic PhospholipaseA2-A: A Potential Therapeutic Target for Prostate Cancer. Clinical Cancer Research, 14(24), 8070-8079. [More Information]
  • Getts, D., Terry, R., Getts, M., Muller, M., Rana, S., Shrestha, B., Radford, J., Van Rooijen, N., Campbell, I., King, N. (2008). Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. The Journal of Experimental Medicine, 205(10), 2319-2337. [More Information]
  • Oliver, B., Lim, S., Wark, P., Laza-Stanca, V., King, N., Black, J., Burgess, J., Roth, M., Johnston, S. (2008). Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Thorax, 63(6), 519-525. [More Information]
  • Getts, D., Balcar, V., Matsumoto, I., Muller, M., King, N. (2008). Viruses and the immune system: their roles in seizure cascade development. Journal of Neurochemistry, 104(5), 1167-1176. [More Information]
  • Muller, M., Carter, S., Hofer, M., Manders, P., Getts, D., Getts, M., Dreykluft, A., Lu, B., Gerard, C., King, N., Campbell, I. (2007). CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System. The Journal of Immunology, 179(5), 2774-2786. [More Information]
  • Kunzelmann, K., Sun, J., Meanger, J., King, N., Cook, D. (2007). Inhibition of airway Na+ transport by respiratory syncytial virus. Journal of Virology, 81(8), 3714-3720. [More Information]
  • King, N., Thomas, S. (2007). Molecules in focus: Indoleamine 2,3-dioxygenase. The International Journal of Biochemistry and Cell Biology, 39(12), 2167-2172. [More Information]
  • Getts, D., Matsumoto, I., Muller, M., Getts, M., Radford, J., Shrestha, B., Campbell, I., King, N. (2007). Role of IFN-gamma in an experimental murine model of West Nile virus-induced seizures. Journal of Neurochemistry, 103(3), 1019-1030. [More Information]
  • Wacher, C., Muller, M., Hofer, M., Getts, D., Zabaras, R., Ousman, S., Terenzi, F., Sen, G., King, N., Campbell, I. (2006). Coordinated regulation and widespread cellular expression of the interferon-stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system following infection with distinct viruses. Journal of Virology, 81(2), 860-871. [More Information]
  • Jayasekera, J., Vinuesa, C., Karupiah, G., King, N. (2006). Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice. Journal of General Virology, 87(Part 11), 3361-3371. [More Information]
  • King, N., Getts, D., Getts, M., Rana, S., Shrestha, B., Kesson, A. (2006). Immunopathology of flavivirus infections. Immunology and Cell Biology, 85(1), 33-42. [More Information]
  • Oliver, B., Johnston, S., Baraket, M., Burgess, J., King, N., Roth, M., Lim, S., Black, J. (2006). Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection. Respiratory Research, 7, 71-71. [More Information]
  • Wu, W., Bao, B., King, N. (2005). Antiviral Role for Indoleamine 2,3-dioxygenase In Vivo in Vaginal Infection by West Nile virus. Tissue Antigens: immune response genetics, 66(5), 464.
  • Pamphlett, R., Kum Jew, S., King, N. (2005). Flaviviruses in motor neuron disease. Muscle and Nerve, 32(1), 108-109. [More Information]
  • Kunzelmann, K., Konig, J., Sun, J., Markovich, D., King, N., Karupiah, G., Young, J., Cook, D. (2004). Acute Effects Of Parainfluenza Virus On Epithelial Electrolyte Transport. Journal of Biological Chemistry, 279(47), 48760-48766. [More Information]
  • Cheng, Y., King, N., Kesson, A. (2004). Major Histocompatibility Complex Class I (Mhc-I) Induction By West Nile Virus: Involvement Of 2 Signaling Pathways In Mhc-I Up-Regulation. The Journal of Infectious Diseases, 189, 658-668. [More Information]
  • Sved, P., Scott, K., McLeod, D., King, N., Singh, J., Tsatralis, T., Nikolov, B., Boulas, J., Nallan, L., Gelb, M., Dong, Q., et al (2004). Oncogenic Action Of Secreted Phospholipase A2 In Prostate Cancer. Cancer Research, 64(19), 6934-6940. [More Information]
  • Arnold, S., Osvath, S., Hall, R., King, N., Sedger, L. (2004). Regulation Of Antigen Processing And Presentation Molecules In West Nile Virus-Infected Human Skin Fibroblasts. Virology, 324(2), 286-296. [More Information]
  • Burke, S., Wen, L., King, N. (2004). Routes Of Inoculation And The Immune Response To A Resolving Genital Flavivirus Infection In A Novel Murine Model. Immunology and Cell Biology, 82(2), 174-183. [More Information]
  • Cheng, Y., King, N., Kesson, A. (2004). The Role Of Tumor Necrosis Factor In Modulating Responses Of Murine Embryo Fibroblasts By Flavivirus, West Nile. Virology, 329(2), 361-370. [More Information]
  • van Haaften-Day, C., Russell, P., Davies, S., King, N., Tattersall, M. (2003). Expression of Fas and FasL in human serous ovarian epithelial tumors. Human Pathology, 34(1), 74-79. [More Information]
  • King, N., Kesson, A. (2003). Interaction of flaviviruses with cells of the vertebrate host and decoy of the immune response. Immunology and Cell Biology, 81(3), 207-216. [More Information]
  • Haywood, M., Spaliviero, J., Jimenez, M., King, N., Handelsman, D., Allan, C. (2003). Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. Endocrinology, 144(2), 509-517. [More Information]
  • Madigan, M., Penfold, P., King, N., Billson, F., Conway, R. (2002). Immunoglobulin superfamily expression in primary retinoblastoma and retinoblastoma cell lines. Oncology Research, 13(2), 103-111.
  • Penfold, P., Wen, L., Madigan, M., King, N., Provis, J. (2002). Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells. Investigative Ophthalmology and Visual Science, 43, 3125-3130.
  • Lu, D., Tian, L., O'Neill, C., King, N. (2002). Regulation of cellular adhesion molecule expression in murine oocytes, peri-implantation and post-implantation embryos. Cell Research, 12(5-6), 373-383.
  • Kesson, A., Cheng, Y., King, N. (2002). Regulation of Immune Recognition Molecules by Flavivirus, West Nile. Viral Immunology, 15(2), 273-283. [More Information]
  • Delikatny, E., van Holst Pellekaan, C., King, N. (2001). Autologous lymphocyte-monocyte co-culture increases NMR-visible and cytoplasmic lipids in the absence of increased markers of lymphocyte activation. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1533 (3), 243-254. [More Information]
  • Ren, B., Sun, J., Hu,, C., Cong, L., Zhang, L., King, N., Verran, D., Sheil, A. (2001). Immunosuppressive effects of tripterygium wilfordii hook f in a rat liver t5ansplant model. Transplantation Proceedings, 33(1-2), 520-521. [More Information]
  • Byrne, S., Halliday, G., Johnston, L., King, N. (2001). Interleukin-1beta But not tumor necrosis factor is involved in West Nile Virus-Induced Langerhans Cell Migration from the Skin in C57BL/6 Mice. Journal of Investigative Dermatology, 117(3), 702-709.
  • Van Reyk, D., King, N., Hunt, N., Dinauer, M. (2001). The intracellular oxidation of 2', 7'-dichlorofluorescin in murine T lymphocytes. Free Radical Biology and Medicine, 30, 82-88.
  • Kesson, A., King, N. (2001). Transcriptional Regulaion of Major Histocompatibility Complex Class I by Flavivirus West Nile is dependent on NF-kB Activation. The Journal of Infectious Diseases, 184, 947-954.
  • Yin, J., Chaufour, X., McLachlan, C., McGuire, M., White, G., King, N., Hambly, B. (2000). Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo. Atherosclerosis, 148(2), 365-374.
  • Yin, J., McLachlan, C., Chaufour, X., McGuire, M., White, G., Turner, V., King, N., Hambly, B. (2000). Growth arrest-specific gene 6 expression in proliferating rabbit vascular smooth muscle cells in vitro and in vivo. Electrophoresis, 21, 3851-3856.

Conferences

  • Chesher, D., Kay, J., King, N. (2005). Adding a reflective layer to a simulation-based learning environment. 12th International Conference on Artificial Intelligence in Education (AIED-2005), Amsterdam, The Netherlands: IOS Press.
  • Chesher, D., Kay, J., King, N. (2005). SIMPRAC: supporting reflective learning within a new computer-based virtual patient simulator. 12th International Conference on Artificial Intelligence in Education (AIED 05) Workshop 11, Amsterdam: University of Amsterdam. [More Information]
  • Chesher, D., Kay, J., King, N. (2003). A web-based virtual patient to support reflective learning. AIED 2003: Artificial Intelligence in Education, Sydney, AU: University of Sydney.
  • Chesher, D., Kay, J., King, N. (2002). A web-based medical case simulation for continuing professional education. ITS2002 workshops.
  • Chesher, D., Kay, J., King, N. (2002). Simprac - Teaching System for management of chronic illness. The AH''2002 Workshop on Adaptive Systems for Web Based Education, Spain: Departmento de Lenguajes y Ciencias de la Computacion Universidad de Malaga. [More Information]

Report

  • Chesher, D., Kay, J., King, N. (2005). SIMPRAC: A web-based virtual patient to support learning through reflection.

Other

  • Chesher, D., Kay, J., King, N. (2004), Simprac - A Software Template to Support Reflective Learning through Case-based Management of Chronic Disease.

2017

  • Peterson, J., Kesson, A., King, N. (2017). A model of auto immune response. BMC Immunology, 18(SUPPL 1), 47-65. [More Information]
  • Peterson, J., Kesson, A., King, N. (2017). A theoretical model of the West Nile Virus survival data. BMC Immunology, 18(Suppl 1), 23-38. [More Information]
  • Zimmermann, J., Hafezi, W., Dockhorn, A., Lorentzen, E., Krauthausen, M., Getts, D., Muller, M., Kuhn, J., King, N. (2017). Enhanced viral clearance and reduced leukocyte infiltration in experimental herpes encephalitis after intranasal infection of CXCR3-deficient mice. Journal of Neurovirology, 23(3), 394-403. [More Information]
  • King, N., Teixeira, M., Mahalingam, S. (2017). Zika Virus: Mechanisms of Infection During Pregnancy. Trends in Microbiology, 25(9), 701-702. [More Information]

2009

  • Kashem, M., Sarker, R., Des Etages, H., Machaalani, R., King, N., McGregor, I., Matsumoto, I. (2009). Comparative proteomics in the corpus callosal sub-regions of postmortem human brain. Neurochemistry International, 55(7), 483-490. [More Information]
  • King, N., Davison, A., Getts, D., Lu, D., Getts, M., Yeung, A., Peterson, J., Kesson, A. (2009). Enhanced antigen processing or immune evasion? West Nile virus and the induction of immune recognition molecules. In Diamond, Michael S. (Eds.), West Nile Encephalitis Virus Infection: Viral Pathogenesis and the Host Immune Response, (pp. 309-339). New York: Springer.
  • Trian, T., Qi, G., Moir, L., Burgess, J., Kuo, C., King, N., Reddel, H., Black, J., Oliver, B., McParland, B. (2009). Rhinovirus-induced Exacerbations of Asthma - How is the β2-adrenoceptor Implicated? American Journal of Respiratory Cell and Molecular Biology, 43(2), 227-233. [More Information]
  • Quintana, A., Muller, M., Frausto, R., Ramos, R., Getts, D., Sanz, E., Hofer, M., Krathausen, M., King, N., Hildago, J., Campbell, I. (2009). Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enchances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis. The Journal of Immunology, 183(3), 2079-2088. [More Information]

2008

  • Patel, M., Singh, J., Niknami, M., Kurek, C., Yao, M., Lu, S., Maclean, F., King, N., Gelb, M., Scott, K., Dong, Q., et al (2008). Cytosolic PhospholipaseA2-A: A Potential Therapeutic Target for Prostate Cancer. Clinical Cancer Research, 14(24), 8070-8079. [More Information]
  • Getts, D., Terry, R., Getts, M., Muller, M., Rana, S., Shrestha, B., Radford, J., Van Rooijen, N., Campbell, I., King, N. (2008). Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. The Journal of Experimental Medicine, 205(10), 2319-2337. [More Information]
  • Oliver, B., Lim, S., Wark, P., Laza-Stanca, V., King, N., Black, J., Burgess, J., Roth, M., Johnston, S. (2008). Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages. Thorax, 63(6), 519-525. [More Information]
  • Getts, D., Balcar, V., Matsumoto, I., Muller, M., King, N. (2008). Viruses and the immune system: their roles in seizure cascade development. Journal of Neurochemistry, 104(5), 1167-1176. [More Information]

2007

  • Muller, M., Carter, S., Hofer, M., Manders, P., Getts, D., Getts, M., Dreykluft, A., Lu, B., Gerard, C., King, N., Campbell, I. (2007). CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System. The Journal of Immunology, 179(5), 2774-2786. [More Information]
  • Kunzelmann, K., Sun, J., Meanger, J., King, N., Cook, D. (2007). Inhibition of airway Na+ transport by respiratory syncytial virus. Journal of Virology, 81(8), 3714-3720. [More Information]
  • King, N., Thomas, S. (2007). Molecules in focus: Indoleamine 2,3-dioxygenase. The International Journal of Biochemistry and Cell Biology, 39(12), 2167-2172. [More Information]
  • Getts, D., Matsumoto, I., Muller, M., Getts, M., Radford, J., Shrestha, B., Campbell, I., King, N. (2007). Role of IFN-gamma in an experimental murine model of West Nile virus-induced seizures. Journal of Neurochemistry, 103(3), 1019-1030. [More Information]

2006

  • Wacher, C., Muller, M., Hofer, M., Getts, D., Zabaras, R., Ousman, S., Terenzi, F., Sen, G., King, N., Campbell, I. (2006). Coordinated regulation and widespread cellular expression of the interferon-stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system following infection with distinct viruses. Journal of Virology, 81(2), 860-871. [More Information]
  • Jayasekera, J., Vinuesa, C., Karupiah, G., King, N. (2006). Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice. Journal of General Virology, 87(Part 11), 3361-3371. [More Information]
  • King, N., Getts, D., Getts, M., Rana, S., Shrestha, B., Kesson, A. (2006). Immunopathology of flavivirus infections. Immunology and Cell Biology, 85(1), 33-42. [More Information]
  • Oliver, B., Johnston, S., Baraket, M., Burgess, J., King, N., Roth, M., Lim, S., Black, J. (2006). Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection. Respiratory Research, 7, 71-71. [More Information]

2005

  • Chesher, D., Kay, J., King, N. (2005). Adding a reflective layer to a simulation-based learning environment. 12th International Conference on Artificial Intelligence in Education (AIED-2005), Amsterdam, The Netherlands: IOS Press.
  • Wu, W., Bao, B., King, N. (2005). Antiviral Role for Indoleamine 2,3-dioxygenase In Vivo in Vaginal Infection by West Nile virus. Tissue Antigens: immune response genetics, 66(5), 464.
  • Pamphlett, R., Kum Jew, S., King, N. (2005). Flaviviruses in motor neuron disease. Muscle and Nerve, 32(1), 108-109. [More Information]
  • Chesher, D., Kay, J., King, N. (2005). SIMPRAC: A web-based virtual patient to support learning through reflection.
  • Chesher, D., Kay, J., King, N. (2005). SIMPRAC: supporting reflective learning within a new computer-based virtual patient simulator. 12th International Conference on Artificial Intelligence in Education (AIED 05) Workshop 11, Amsterdam: University of Amsterdam. [More Information]

2004

  • Kunzelmann, K., Konig, J., Sun, J., Markovich, D., King, N., Karupiah, G., Young, J., Cook, D. (2004). Acute Effects Of Parainfluenza Virus On Epithelial Electrolyte Transport. Journal of Biological Chemistry, 279(47), 48760-48766. [More Information]
  • Cheng, Y., King, N., Kesson, A. (2004). Major Histocompatibility Complex Class I (Mhc-I) Induction By West Nile Virus: Involvement Of 2 Signaling Pathways In Mhc-I Up-Regulation. The Journal of Infectious Diseases, 189, 658-668. [More Information]
  • Sved, P., Scott, K., McLeod, D., King, N., Singh, J., Tsatralis, T., Nikolov, B., Boulas, J., Nallan, L., Gelb, M., Dong, Q., et al (2004). Oncogenic Action Of Secreted Phospholipase A2 In Prostate Cancer. Cancer Research, 64(19), 6934-6940. [More Information]
  • Arnold, S., Osvath, S., Hall, R., King, N., Sedger, L. (2004). Regulation Of Antigen Processing And Presentation Molecules In West Nile Virus-Infected Human Skin Fibroblasts. Virology, 324(2), 286-296. [More Information]
  • Burke, S., Wen, L., King, N. (2004). Routes Of Inoculation And The Immune Response To A Resolving Genital Flavivirus Infection In A Novel Murine Model. Immunology and Cell Biology, 82(2), 174-183. [More Information]
  • Chesher, D., Kay, J., King, N. (2004), Simprac - A Software Template to Support Reflective Learning through Case-based Management of Chronic Disease.
  • Cheng, Y., King, N., Kesson, A. (2004). The Role Of Tumor Necrosis Factor In Modulating Responses Of Murine Embryo Fibroblasts By Flavivirus, West Nile. Virology, 329(2), 361-370. [More Information]

2003

  • Chesher, D., Kay, J., King, N. (2003). A web-based virtual patient to support reflective learning. AIED 2003: Artificial Intelligence in Education, Sydney, AU: University of Sydney.
  • van Haaften-Day, C., Russell, P., Davies, S., King, N., Tattersall, M. (2003). Expression of Fas and FasL in human serous ovarian epithelial tumors. Human Pathology, 34(1), 74-79. [More Information]
  • King, N., Shrestha, B., Kesson, A. (2003). Immune modulation by flaviviruses. In Karl Maramorosch,F.A.Murphy,A.J.Shatkin,T.J.Chambers + T.P.Monath (Eds.), The Flaviviruses: Pathogenesis and Immunity, Volume 60 (Advances in Virus Research), (pp. 121-155). New York: Academic Press.
  • King, N., Kesson, A. (2003). Interaction of flaviviruses with cells of the vertebrate host and decoy of the immune response. Immunology and Cell Biology, 81(3), 207-216. [More Information]
  • Haywood, M., Spaliviero, J., Jimenez, M., King, N., Handelsman, D., Allan, C. (2003). Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. Endocrinology, 144(2), 509-517. [More Information]

2002

  • Chesher, D., Kay, J., King, N. (2002). A web-based medical case simulation for continuing professional education. ITS2002 workshops.
  • Madigan, M., Penfold, P., King, N., Billson, F., Conway, R. (2002). Immunoglobulin superfamily expression in primary retinoblastoma and retinoblastoma cell lines. Oncology Research, 13(2), 103-111.
  • Penfold, P., Wen, L., Madigan, M., King, N., Provis, J. (2002). Modulation of permeability and adhesion molecule expression by human choroidal endothelial cells. Investigative Ophthalmology and Visual Science, 43, 3125-3130.
  • Lu, D., Tian, L., O'Neill, C., King, N. (2002). Regulation of cellular adhesion molecule expression in murine oocytes, peri-implantation and post-implantation embryos. Cell Research, 12(5-6), 373-383.
  • Kesson, A., Cheng, Y., King, N. (2002). Regulation of Immune Recognition Molecules by Flavivirus, West Nile. Viral Immunology, 15(2), 273-283. [More Information]
  • Chesher, D., Kay, J., King, N. (2002). Simprac - Teaching System for management of chronic illness. The AH''2002 Workshop on Adaptive Systems for Web Based Education, Spain: Departmento de Lenguajes y Ciencias de la Computacion Universidad de Malaga. [More Information]

2001

  • Delikatny, E., van Holst Pellekaan, C., King, N. (2001). Autologous lymphocyte-monocyte co-culture increases NMR-visible and cytoplasmic lipids in the absence of increased markers of lymphocyte activation. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1533 (3), 243-254. [More Information]
  • Ren, B., Sun, J., Hu,, C., Cong, L., Zhang, L., King, N., Verran, D., Sheil, A. (2001). Immunosuppressive effects of tripterygium wilfordii hook f in a rat liver t5ansplant model. Transplantation Proceedings, 33(1-2), 520-521. [More Information]
  • Byrne, S., Halliday, G., Johnston, L., King, N. (2001). Interleukin-1beta But not tumor necrosis factor is involved in West Nile Virus-Induced Langerhans Cell Migration from the Skin in C57BL/6 Mice. Journal of Investigative Dermatology, 117(3), 702-709.
  • Van Reyk, D., King, N., Hunt, N., Dinauer, M. (2001). The intracellular oxidation of 2', 7'-dichlorofluorescin in murine T lymphocytes. Free Radical Biology and Medicine, 30, 82-88.
  • Kesson, A., King, N. (2001). Transcriptional Regulaion of Major Histocompatibility Complex Class I by Flavivirus West Nile is dependent on NF-kB Activation. The Journal of Infectious Diseases, 184, 947-954.

2000

  • Yin, J., Chaufour, X., McLachlan, C., McGuire, M., White, G., King, N., Hambly, B. (2000). Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo. Atherosclerosis, 148(2), 365-374.
  • Yin, J., McLachlan, C., Chaufour, X., McGuire, M., White, G., Turner, V., King, N., Hambly, B. (2000). Growth arrest-specific gene 6 expression in proliferating rabbit vascular smooth muscle cells in vitro and in vivo. Electrophoresis, 21, 3851-3856.

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