Professor Nicholas Manolios

Professor
Medicine, Westmead Clinical School

Telephone +61 2 9845 6305
Fax +61 2 98458317

Website Related website
Honours in Medical Sciences at Westmead

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Research interests

Professor Nicholas Manolios research interests are: (i) Structure and assembly of the T-cell antigen receptor, in particular, its role in the predisposition and causation of auto-immune and inflammatory rheumatic disorders, and (ii) Structure-function relationships of T cell assembly and T-cell activation, and how synthetic peptides may be used as therapeutic agents to suppress inflammation. Recent research hs focussed on drug delivery.

Current research students

Project title Research student
Investigation of Endocannabinoid-Based Nanoparticles Targeted to the Synovium for the Treatment of Arthritis Nicola BARRIE

Selected grants

2016

  • Determining the scope of action of a novel immunomodulatory peptide; Manolios N, Limaye A, Ali M; Rebecca Cooper Foundation/Research Grant.

2010

  • Retroviral gene expression of immunosuppressive peptides in the prevention of islet transplantation rejection in mice.; Manolios N, Wong M; Wenkart Foundation/Scholarship.

2009

  • LP0989906, ARC Linkage - UWS Lead - Motherhood choices: a decision aid for women with rheumatoid ar; Manolios N, Sharpe L.
  • Peptide-Lipid interactions: Effect of cellular milieu on biophysical properties of transmembrane peptides; Manolios N; DVC Research/Bridging Support Grant.
  • Application of a cyclic peptide (C1) for the treatment of T-cell mediated inflammatory disease; Manolios N; Royal Australasian College of Physicians/Specific Area Research Awards.

2006

  • Not Known - To be advised; Manolios N; Rebecca L Cooper Medical Research Foundation/Medical Research Foundation.

2003

  • Natural Killer Cell Transmembrane Peptides - evaluation for Clinical Application; Manolios N, Kola R, Jonak Z; Glaxo SmithKline Aust Pty Ltd/BLO Project.

2002

  • Development of new anti-arthritic drugs; Manolios N; Clive & Vera Ramaciotti Foundation/Research Grants.

2000

  • Transgenomic WAVE 2100 denaturing HPLC system for DNA variant analysis; Farrell G, Clarke C, Cunningham A, deFazio A, Kirk J, Leary J, Liddle C, Manolios N, Mitchell P, Stewart G, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Evaluation of specificity, mechanisms of action and therapeutic use of peptides that disrupt T-cell antigen receptor; Manolios N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • T cell receptor peptide treatment in experimental allergic encephalomyelitis; Pollard J, Manolios N, Sander S; National Multiple Sclerosis Society of Australia/Project Grants.

Selected publications

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Journals

  • Gunaratne, S., Zwicker, V., New, E., Jolliffe, K., Manolios, N. (2017). A new method of detecting pyrophosphate levels in joint fluid. Internal Medicine Journal, 47(S2), 14-14.
  • Barrie, N., Kuruppu, V., Manolios, E., Manolios, N., Ali, M., Moghaddam, M. (2017). Endocannabinoids in arthritis: current views and perspective. International Journal of Rheumatic Diseases, 20(7), 789-797. [More Information]
  • Manolios, N., Ali, M., Camden, B., Aflaky, E., Pavic, K., Markewycz, A., Costa, R., Angelides, S. (2016). Evaluating disease activity in patients with ankylosing spondylitis and rheumatoid arthritis using 99mtc-glucosamine. European Journal of Rheumatology, 3, 65-72. [More Information]
  • Tunnicliffe, D., Singh-Grewal, D., Chaitow, J., Mackie, F., Manolios, N., Lin, M., O'Neill, S., Ralph, A., Craig, J., Tong, A. (2016). Lupus Means Sacrifices: Perspectives of Adolescents and Young Adults with Systemic Lupus Erythematosus. Arthritis Care and Research, 68(6), 828-837. [More Information]
  • Chan, M., Kefford, R., Carlino, M., Clements, A., Manolios, N. (2015). Arthritis and Tenosynovitis Associated With the Anti-PD1 Antibody Pembrolizumab in Metastatic Melanoma. Journal of Immunotherapy, 38(1), 37-39. [More Information]
  • Meade (nee Covic), T., Dowswell, E., Manolios, N., Sharpe, L. (2015). The motherhood choices decision aid for women with rheumatoid arthritis increases knowledge and reduces decisional conflict: a randomized controlled trial. BMC Musculoskeletal Disorders, 16(1), 1-8. [More Information]
  • Efani, T., Manolios, N., Howe, G., Spencer, D. (2014). Acute gross painless transudative ascites in a patient with lupus. BMJ Case Reports, 17 January 2014, 1-2. [More Information]
  • Aflaki, E., Erfani, T., Manolios, N., Schifter, M. (2014). An approach to the patient with a dry mouth. Medicine Today, 15(4), 30-37.
  • Ali, M., Amon, M., Bender, V., Bolte, A., Separovic, F., Benson, H., Manolios, N. (2014). Cyclization enhances function of linear anti-arthritic peptides. Clinical Immunology, 150(1), 121-133. [More Information]
  • Samiei, A., Tamadon, A., Samani, S., Manolios, N., Kamali Sarvestani, E. (2014). Engraftment of plasma membrane vesicles into liposomes: A new method for designing of liposome-based vaccines. Iranian Journal of Basic Medical Sciences, 17(10), 772-778.
  • Wong, M., Tso, A., Ali, M., Hawthorne, W., Manolios, N. (2014). Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Diabetes & Metabolism, 40, 229-234. [More Information]
  • Vanniasinghe, A., Manolios, N., Schibeci, S., Lakhiani, C., Kamali-Sarvestani, E., Sharma, R., Kumar, V., Moghaddam, M., Ali, M., Bender, V. (2014). Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis. Clinical Immunology, 151(1), 43-54. [More Information]
  • Angelides, S., El-Mashaleh, M., Anagnostou, M., Howe, G., Spencer, D., Kumar, V., Manolios, N. (2014). The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience. Nuclear Medicine Communications, 35(6), 655-668. [More Information]
  • Meade (nee Covic), T., Cumming, S., Hallab, L., Spencer, D., Howe, G., Manolios, N. (2013). A preliminary investigation of cognitive function in rheumatoid arthritis patients on long term methotrexate treatment. Journal of Health Psychology, 18(10), 1353-1359. [More Information]
  • Raguine, L., Ali, M., Bender, V., Diefenbach, E., Doddareddy, M., Hibbs, D., Manolios, N. (2013). Alanine Scan of an Immunosuppressive Peptide (CP): Analysis of Structure-Function Relationships. Chemical Biology & Drug Design, 81(2), 167-174. [More Information]
  • Jordan, A., Spencer, D., Howe, G., Manolios, N. (2013). Cauda Equina Syndrome in Ankylosing Spondylitis. Journal of Clinical Rheumatology, 19(3), 163-163. [More Information]
  • Meade (nee Covic), T., Manolios, N. (2013). Cognitive function in rheumatoid arthritis. Arthritis Care and Research, 65(8), 1390-1390. [More Information]
  • Williams, A., Bloomfield, L., Milthorpe, E., Aspinall, D., Filocamo, K., Wellsmore, T., Manolios, N., Jayasinghe, U., Harris, M. (2013). Effectiveness of moving on: an Australian designed generic self-management program for people with a chronic illness. BMC Health Services Research, 13(1), 1-15. [More Information]
  • Manolios, N., Burneikis, A., Spencer, D., Howe, G. (2013). Failure of anti-TNF therapy to reactivate previously septic prosthetic joints. BMJ Case Reports, Article number 009827, 1-3. [More Information]
  • Meade (nee Covic), T., Sharpe, L., Hallab, L., Aspanell, D., Manolios, N. (2013). Navigating Motherhood Choices in the context of Rheumatoid Arthritis: Women's Stories. Musculoskeletal Care, 11(2), 73-82. [More Information]
  • Meade (nee Covic), T., Cumming, S., Pallant, J., Manolios, N., Emery, P., Conaghan, P., Tennant, A. (2012). Depression and Anxiety in Patients with Rheumatoid Arthritis: Prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the Hospital, Anxiety and Depression Scale (HADS). BMC Psychiatry, 12, 1-10. [More Information]
  • Tong, D., Manolios, N., Howe, G., Spencer, D. (2012). New onset sarcoid-like granulomatosis developing during anti-TNF therapy: an under-recognised complication. Internal Medicine Journal, 42(1), 89-94. [More Information]
  • Spencer, D., Howe, G., Manolios, N. (2012). No more excuses: fracture liaison services work and are cost-effective. Medical Journal of Australia, 196(6), 384-384. [More Information]
  • Ali, M., Vanniasinghe, A., Kumar, V., Barnett, R., Alberto, R., Manolios, N. (2011). 99mTc-technetium labeling of antiarthritic peptides to evaluate homing and biodistribution at inflamed joints. Nuclear Medicine and Biology, 38(5), 751-756. [More Information]
  • Lu, Y., Sharma, R., Ali, M., Byth Wilson, K., Manolios, N. (2011). Anti-Arthritic Effects of Immunomodulatory Peptide Injected in Joints. Current Drug Delivery, 8(6), 600-606. [More Information]
  • Zheng, G., Torres, A., Ali, M., Manolios, N., Price, W. (2011). NMR Study of the structure and self-association of core peptide in aqueous solution and DPC micelles. Biopolymers (Peptide Science), 96(2), 177-180. [More Information]
  • Otvos, L., Shao, W., Vanniasinghe, A., Amon, M., Holub, M., Kovalszky, I., Wade, J., Doll, M., Cohen, P., Manolios, N., et al (2011). Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides, 32(8), 1567-1574. [More Information]
  • Russo, R., Hughes, M., Manolios, N. (2010). Biopsy Diagnosis of Early Myositis Ossificans Without Radiologic Evidence of Calcification: Success of Early Surgical Resection. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 16(8), 385-7. [More Information]
  • Tong, D., Karunaratne, N., Howe, G., Spencer, D., Manolios, N. (2010). Clinical images: Calcifying pseudoneoplasm of the neuraxis. Arthritis & Rheumatology, 62(3), 704. [More Information]
  • Wong, M., Hawthorne, W., Manolios, N. (2010). Gene Therapy in Diabetes. Self Nonself, 1(3), 165-175. [More Information]
  • Tong, D., Murad, A., Manolios, N., Howe, G., Spencer, D. (2010). Pseudohypercalcaemia in mixed cryoglobulinaemia (IgMκ/polyclonal IgG): a rare complication of Sjögren's syndrome. Clinical Rheumatology, 29(4), 439-441. [More Information]
  • Manolios, N., Ali, M., Bender, V. (2010). T-cell antigen receptor (TCR) transmembrane peptides: A new paradigm for the treatment of autoimmune diseases. Cell adhesion & migration, 4(2), 273-83. [More Information]
  • Varatharajan, N., Lim, I., Anandacoomarasamy, A., Russo, R., Byth Wilson, K., Spencer, D., Manolios, N., Howe, G. (2009). Methotrexate: long-term safety and efficacy in an Australian consultant rheumatology practice. Internal Medicine Journal, 39(4), 228-236. [More Information]
  • Tong, D., Eather, S., Manolios, N. (2009). Psoriatic arthritis and chronic lymphoedema: treatment efficacy by adalimumab. Clinical Rheumatology, 28(11), 1349-1350. [More Information]
  • Vanniasinghe, A., Bender, V., Manolios, N. (2009). The Potential of Liposomal Drug Delivery for the Treatment of Inflammatory Arthritis. Seminars in Arthritis and Rheumatism, 39(3), 182-196. [More Information]
  • Englert, H., Kirkham, S., Moore, J., Poon, T., Katelaris, C., McGill, N., Schrieber, L., Manolios, N. (2008). Autologous stem cell transplantation in diffuse scleroderma: impact on hand structure and function. Internal Medicine Journal, 38(9), 692-696. [More Information]
  • Englert, H., Roberts-Thomson, P., Byth Wilson, K., Manolios, N. (2008). Familial scleroderma: nature, nurture or both? Internal Medicine Journal, 38(4), 235-242. [More Information]
  • Amon, M., Manolios, N. (2008). Hypothesis: TCR signal transduction-A novel tri-modular signaling system. Molecular Immunology, 45(4), 876-880. [More Information]
  • Amon, M., Ali, M., Manolios, N., Bender, V., Hall, K., Aguilar, M., Aldrich-Wright, J. (2008). Kinetic and conformational properties of a novel T-cell antigen receptor transmembrane peptide in model membranes. Journal of Peptide Science, 14, 714-724. [More Information]
  • Forchap, S., Anandacoomarasamy, A., Wicks, J., Di Virgilio, F., Baricordi, O., Rubbini, M., Trotta, F., Manolios, N. (2008). P2X gene polymorphisms do not appear to be a susceptibility gene locus in sporadic cases of systemic lupus erythematosus. Tissue Antigens: immune response genetics, 72(5), 487-490. [More Information]
  • Manolios, N., Ali, M., Amon, M., Bender, V. (2008). Therapeutic application of transmembrane T and natural killer cell receptor peptides. Advances in Experimental Medicine and Biology, 640, 208-219. [More Information]
  • Chan, E., Amon, M., Marano, R., Wimmer, N., Kearns, P., Manolios, N., Rakoczy, P., Toth, I. (2007). Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. Bioorganic and Medicinal Chemistry, 15(12), 4091-4097. [More Information]
  • Ali, M., Manolios, N. (2007). Peptide-based therapies for arthritis. International Journal of Clinical Rheumatology, 2(3), 287-296. [More Information]
  • Ridda, I., MacIntyre, C., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, G., Kovoor, P., Manolios, N., Fox, J. (2007). Predictors of pneumococcal vaccination uptake in hospitalized patients aged 65 years and over shortly following the commencement of a publicly funded national pneumococcal vaccination program in Australia. Human Vaccines, 3(3), 57-60. [More Information]
  • Englert, H., Manolios, N., Kirkham, S. (2007). Reconstructive hand surgery for scleroderma joint contractures. Journal Of Hand Surgery (American volume), 32(7), 1107-1112. [More Information]
  • Kumar, V., Ali, M., Angelides, S., Manolios, N. (2007). Synthesis and characterization of 99mTc-Glucosamine & 99mTc-His-CP and evaluation of their utility in imaging inflammatory arthritis. Australian and New Zealand Nuclear Medicine, 38(3), 10-13.
  • Kurosaka, N., Bolte, A., Ali, M., Manolios, N. (2007). T-Cell Antigen Receptor Assembly and Cell Surface Expression Is Not Affected by Treatment with T-Cell Antigen Receptor-Alpha Chain Transmembrane Peptide. Protein and Peptide Letters, 14(3), 299-303. [More Information]
  • Kurosaka, N., Ali, M., Byth Wilson, K., Manolios, N. (2007). The mode of anti-arthritic peptide delivery impacts on the severity and outcome of adjuvant induced arthritis. APLAR Journal of Rheumatology, 10(3), 198-203. [More Information]
  • Al-Mashaleh, M., Packham, D., Manolios, N. (2006). Clinical Images: Bazin's Disease (Erythema Induratum). Journal of Rheumatology, 33(7), 1415. [More Information]
  • Collier, S., Bolte, A., Manolios, N. (2006). Discrepancy in CD3-Transmembrane Peptide Activity between In Vitro and In Vivo T-Cell Inhibition. Scandinavian Journal of Immunology, 64(4), 388-391. [More Information]
  • Manolios, N., Samaras, K. (2006). Hypercarotenaemia. Internal Medicine Journal, 36(8), 534. [More Information]
  • Vandebona, H., Ali, M., Amon, M., Bender, V., Manolios, N. (2006). Immunoreceptor transmembrane peptides and their effect on natural killer (NK) cell cytotoxicity. Protein and Peptide Letters, 13(10), 1017-1024. [More Information]
  • Russo, R., Medbury, H., Guiffre, A., Englert, H., Manolios, N. (2006). Lack of increased expression of cell surface markers for circulating fibrocyte progenitors in limited scleroderma. Clinical Rheumatology, 26(7), 1136-1141. [More Information]
  • Amon, M., Ali, M., Bender, V., Chan, Y., Toth, I., Manolios, N. (2006). Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hydrophobic peptide dramatically enhances in vitro and in vivo function. Biochimica et Biophysica Acta, 1763 (8), 879-888. [More Information]
  • Anandacoomarasamy, A., Peduto, A., Howe, G., Manolios, N. (2006). Magnetic resonance imaging in Lofgren's syndrome: demonstration of periarthritis. Clinical Rheumatology, 26, 572-5. [More Information]
  • Al-Mashaleh, M., Bak, H., Moore, J., Manolios, N., Englert, H. (2006). Resolution of sclerodermatous myocarditis after autologous stem cell transplantation. Annals of the Rheumatic Diseases, 65(9), 1247-8. [More Information]
  • Ali, M., Salam, N., Amon, M., Bender, V., Hibbs, D., Manolios, N. (2006). T-cell antigen receptor-alpha chain transmembrane peptides: correlation between structure and function. International Journal of Peptide Research and Therapeutics, 12(3), 261-267. [More Information]
  • Anandacoomarasamy, A., Howe, G., Manolios, N. (2005). Advanced refractory polymyositis responding to infliximab. Rheumatology, 44(4), 562-3. [More Information]
  • Lim, I., Kefford, R., Manolios, N. (2005). Chemotherapeutic induced fascial oedema. Annals of the Rheumatic Diseases, 64(1), 162-163. [More Information]
  • Geevasinga, N., Jeremy, R., Crombie, C., Manolios, N. (2005). Histiocytosis and bone: experience from one major Sydney teaching hospital. Internal Medicine Journal, 35(10), 622-625. [More Information]
  • Ali, M., Manolios, N., Bender, V., Amon, M. (2005). Hydrophobic transmembrane-peptide lipid conjugations enhance membrane binding and functional activity in T-cells. Bioconjugate Chemistry, 16(6), 1556-63. [More Information]
  • Anandacoomarasamy, A., Bak, H., Peduto, A., Manolios, N. (2005). Magnetic resonance imaging in pachydermodactyly. Journal of Rheumatology, 32(11), 2239-41. [More Information]
  • Ali, M., Manolios, N. (2005). Proteomics in rheumatology: a new direction for old diseases. Seminars in Arthritis and Rheumatism, 35(2), 67-76. [More Information]
  • Englert, H., Joyner, J., Bade, R., Thompson, M., Morris, D., Chambers, P., Carroll, G., Manolios, N. (2005). Systemic scleroderma: a spatiotemporal clustering. Internal Medicine Journal, 35(4), 228-233. [More Information]
  • Ali, M., Amon, M., Kurosaka, N., Manolios, N. (2004). Photoactive benzophenone labelled peptide. APLAR Journal of Rheumatology, 7(1), 11-12. [More Information]
  • Bender, V., Ali, M., Amon, M., Diefenbach, E., Manolios, N. (2004). T Cell Antigen Receptor Peptide-Lipid Membrane Interactions Using Surface Plasmon Resonance. Journal of Biological Chemistry, 279(52), 54002-54007. [More Information]
  • Wong, P., Spencer, D., McElduff, P., Manolios, N., Larcos, G., Howe, G. (2003). Secondary screening for osteoporosis in patients admitted with minimal-trauma fracture to a major teaching hospital. Internal Medicine Journal, 33(11), 505-510. [More Information]
  • Huynh, N., Ffrench, R., Boadle, R., Manolios, N. (2003). Transmembrane T-cell receptor peptides inhibit B-and natural killer-cell function. Immunology, 108(4), 458-464. [More Information]
  • Buhler, M., Craig, M., Donaghue, K., Badhwar, P., Willis, J., Manolios, N., Tait, B., Silink, M., Bennetts, B., Stewart, G. (2002). CCR5 Genotyping in an Australian and New Zealand type 1 Diabetes Cohort. Autoimmunity, 65(7), 457-461. [More Information]
  • Wang, X., Djordjevic, J., Kurosaka, N., Schibeci, S., Lee, K., Williamson, P., Manolios, N. (2002). T-Cell Antigen Receptor Peptides Inhibit Signal Transduction within the Membrane Bilayer. Clinical Immunology, 105(2), 199-207. [More Information]
  • Hassett, G., Harnett, P., Manolios, N. (2001). Scleroderma in association with the use of docetaxel (taxotere) for breast cancer. Clinical and Experimental Rheumatology, 19, 197-200.
  • Huang, Q., Teutsch, S., Buhler, M., Bennetts, B., Heard, R., Manolios, N., Stewart, G. (2000). Evaluation of the Apo-1/Fas promoter Mva 1 polymorphism in multiple sclerosis. Multiple Sclerosis: clinical and laboratory research, 6(1), 14-18.

Conferences

  • Lindley, R., MacIntyre, R., Ridda, I., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). A new method of assessing frailty in older patients recruited into pneumonia vaccination trials. 5th International Symposium on Pneumococci and Pneumococcal Diseases, Australia: Abstract Book.
  • Lindley, R., MacIntyre, R., Ridda, I., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). A new method of assessing frailty in older patients recruited into randomised controlled trials. Australian Society for Geriatric Medicine Annual Scientific Meeting, Australia: Blackwell Publishers.
  • Ridda, I., MacIntyre, R., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). Vaccination uptake in hospitalised geriatric patients 4-6 months after commencement of a funded national pneumococcal vaccination program for >65's. 5th International Symposium on Pneumococci and Pneumococcal Diseases, Australia: Abstract Book.
  • Ridda, I., MacIntyre, R., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). Vaccination uptake in hospitalised geriatric patients within the first year after commencement of a funded national pneumococcal vaccination program for > 65 year olds. Australian Society for Geriatric Medicine Annual Scientific Meeting, Australia: Blackwell Publishers.

2017

  • Gunaratne, S., Zwicker, V., New, E., Jolliffe, K., Manolios, N. (2017). A new method of detecting pyrophosphate levels in joint fluid. Internal Medicine Journal, 47(S2), 14-14.
  • Barrie, N., Kuruppu, V., Manolios, E., Manolios, N., Ali, M., Moghaddam, M. (2017). Endocannabinoids in arthritis: current views and perspective. International Journal of Rheumatic Diseases, 20(7), 789-797. [More Information]

2016

  • Manolios, N., Ali, M., Camden, B., Aflaky, E., Pavic, K., Markewycz, A., Costa, R., Angelides, S. (2016). Evaluating disease activity in patients with ankylosing spondylitis and rheumatoid arthritis using 99mtc-glucosamine. European Journal of Rheumatology, 3, 65-72. [More Information]
  • Tunnicliffe, D., Singh-Grewal, D., Chaitow, J., Mackie, F., Manolios, N., Lin, M., O'Neill, S., Ralph, A., Craig, J., Tong, A. (2016). Lupus Means Sacrifices: Perspectives of Adolescents and Young Adults with Systemic Lupus Erythematosus. Arthritis Care and Research, 68(6), 828-837. [More Information]

2015

  • Chan, M., Kefford, R., Carlino, M., Clements, A., Manolios, N. (2015). Arthritis and Tenosynovitis Associated With the Anti-PD1 Antibody Pembrolizumab in Metastatic Melanoma. Journal of Immunotherapy, 38(1), 37-39. [More Information]
  • Meade (nee Covic), T., Dowswell, E., Manolios, N., Sharpe, L. (2015). The motherhood choices decision aid for women with rheumatoid arthritis increases knowledge and reduces decisional conflict: a randomized controlled trial. BMC Musculoskeletal Disorders, 16(1), 1-8. [More Information]

2014

  • Efani, T., Manolios, N., Howe, G., Spencer, D. (2014). Acute gross painless transudative ascites in a patient with lupus. BMJ Case Reports, 17 January 2014, 1-2. [More Information]
  • Aflaki, E., Erfani, T., Manolios, N., Schifter, M. (2014). An approach to the patient with a dry mouth. Medicine Today, 15(4), 30-37.
  • Ali, M., Amon, M., Bender, V., Bolte, A., Separovic, F., Benson, H., Manolios, N. (2014). Cyclization enhances function of linear anti-arthritic peptides. Clinical Immunology, 150(1), 121-133. [More Information]
  • Samiei, A., Tamadon, A., Samani, S., Manolios, N., Kamali Sarvestani, E. (2014). Engraftment of plasma membrane vesicles into liposomes: A new method for designing of liposome-based vaccines. Iranian Journal of Basic Medical Sciences, 17(10), 772-778.
  • Wong, M., Tso, A., Ali, M., Hawthorne, W., Manolios, N. (2014). Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Diabetes & Metabolism, 40, 229-234. [More Information]
  • Vanniasinghe, A., Manolios, N., Schibeci, S., Lakhiani, C., Kamali-Sarvestani, E., Sharma, R., Kumar, V., Moghaddam, M., Ali, M., Bender, V. (2014). Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis. Clinical Immunology, 151(1), 43-54. [More Information]
  • Angelides, S., El-Mashaleh, M., Anagnostou, M., Howe, G., Spencer, D., Kumar, V., Manolios, N. (2014). The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience. Nuclear Medicine Communications, 35(6), 655-668. [More Information]

2013

  • Meade (nee Covic), T., Cumming, S., Hallab, L., Spencer, D., Howe, G., Manolios, N. (2013). A preliminary investigation of cognitive function in rheumatoid arthritis patients on long term methotrexate treatment. Journal of Health Psychology, 18(10), 1353-1359. [More Information]
  • Raguine, L., Ali, M., Bender, V., Diefenbach, E., Doddareddy, M., Hibbs, D., Manolios, N. (2013). Alanine Scan of an Immunosuppressive Peptide (CP): Analysis of Structure-Function Relationships. Chemical Biology & Drug Design, 81(2), 167-174. [More Information]
  • Jordan, A., Spencer, D., Howe, G., Manolios, N. (2013). Cauda Equina Syndrome in Ankylosing Spondylitis. Journal of Clinical Rheumatology, 19(3), 163-163. [More Information]
  • Meade (nee Covic), T., Manolios, N. (2013). Cognitive function in rheumatoid arthritis. Arthritis Care and Research, 65(8), 1390-1390. [More Information]
  • Williams, A., Bloomfield, L., Milthorpe, E., Aspinall, D., Filocamo, K., Wellsmore, T., Manolios, N., Jayasinghe, U., Harris, M. (2013). Effectiveness of moving on: an Australian designed generic self-management program for people with a chronic illness. BMC Health Services Research, 13(1), 1-15. [More Information]
  • Manolios, N., Burneikis, A., Spencer, D., Howe, G. (2013). Failure of anti-TNF therapy to reactivate previously septic prosthetic joints. BMJ Case Reports, Article number 009827, 1-3. [More Information]
  • Meade (nee Covic), T., Sharpe, L., Hallab, L., Aspanell, D., Manolios, N. (2013). Navigating Motherhood Choices in the context of Rheumatoid Arthritis: Women's Stories. Musculoskeletal Care, 11(2), 73-82. [More Information]

2012

  • Meade (nee Covic), T., Cumming, S., Pallant, J., Manolios, N., Emery, P., Conaghan, P., Tennant, A. (2012). Depression and Anxiety in Patients with Rheumatoid Arthritis: Prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the Hospital, Anxiety and Depression Scale (HADS). BMC Psychiatry, 12, 1-10. [More Information]
  • Tong, D., Manolios, N., Howe, G., Spencer, D. (2012). New onset sarcoid-like granulomatosis developing during anti-TNF therapy: an under-recognised complication. Internal Medicine Journal, 42(1), 89-94. [More Information]
  • Spencer, D., Howe, G., Manolios, N. (2012). No more excuses: fracture liaison services work and are cost-effective. Medical Journal of Australia, 196(6), 384-384. [More Information]

2011

  • Ali, M., Vanniasinghe, A., Kumar, V., Barnett, R., Alberto, R., Manolios, N. (2011). 99mTc-technetium labeling of antiarthritic peptides to evaluate homing and biodistribution at inflamed joints. Nuclear Medicine and Biology, 38(5), 751-756. [More Information]
  • Lu, Y., Sharma, R., Ali, M., Byth Wilson, K., Manolios, N. (2011). Anti-Arthritic Effects of Immunomodulatory Peptide Injected in Joints. Current Drug Delivery, 8(6), 600-606. [More Information]
  • Zheng, G., Torres, A., Ali, M., Manolios, N., Price, W. (2011). NMR Study of the structure and self-association of core peptide in aqueous solution and DPC micelles. Biopolymers (Peptide Science), 96(2), 177-180. [More Information]
  • Otvos, L., Shao, W., Vanniasinghe, A., Amon, M., Holub, M., Kovalszky, I., Wade, J., Doll, M., Cohen, P., Manolios, N., et al (2011). Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides, 32(8), 1567-1574. [More Information]

2010

  • Russo, R., Hughes, M., Manolios, N. (2010). Biopsy Diagnosis of Early Myositis Ossificans Without Radiologic Evidence of Calcification: Success of Early Surgical Resection. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 16(8), 385-7. [More Information]
  • Tong, D., Karunaratne, N., Howe, G., Spencer, D., Manolios, N. (2010). Clinical images: Calcifying pseudoneoplasm of the neuraxis. Arthritis & Rheumatology, 62(3), 704. [More Information]
  • Wong, M., Hawthorne, W., Manolios, N. (2010). Gene Therapy in Diabetes. Self Nonself, 1(3), 165-175. [More Information]
  • Tong, D., Murad, A., Manolios, N., Howe, G., Spencer, D. (2010). Pseudohypercalcaemia in mixed cryoglobulinaemia (IgMκ/polyclonal IgG): a rare complication of Sjögren's syndrome. Clinical Rheumatology, 29(4), 439-441. [More Information]
  • Manolios, N., Ali, M., Bender, V. (2010). T-cell antigen receptor (TCR) transmembrane peptides: A new paradigm for the treatment of autoimmune diseases. Cell adhesion & migration, 4(2), 273-83. [More Information]

2009

  • Varatharajan, N., Lim, I., Anandacoomarasamy, A., Russo, R., Byth Wilson, K., Spencer, D., Manolios, N., Howe, G. (2009). Methotrexate: long-term safety and efficacy in an Australian consultant rheumatology practice. Internal Medicine Journal, 39(4), 228-236. [More Information]
  • Tong, D., Eather, S., Manolios, N. (2009). Psoriatic arthritis and chronic lymphoedema: treatment efficacy by adalimumab. Clinical Rheumatology, 28(11), 1349-1350. [More Information]
  • Vanniasinghe, A., Bender, V., Manolios, N. (2009). The Potential of Liposomal Drug Delivery for the Treatment of Inflammatory Arthritis. Seminars in Arthritis and Rheumatism, 39(3), 182-196. [More Information]

2008

  • Englert, H., Kirkham, S., Moore, J., Poon, T., Katelaris, C., McGill, N., Schrieber, L., Manolios, N. (2008). Autologous stem cell transplantation in diffuse scleroderma: impact on hand structure and function. Internal Medicine Journal, 38(9), 692-696. [More Information]
  • Englert, H., Roberts-Thomson, P., Byth Wilson, K., Manolios, N. (2008). Familial scleroderma: nature, nurture or both? Internal Medicine Journal, 38(4), 235-242. [More Information]
  • Amon, M., Manolios, N. (2008). Hypothesis: TCR signal transduction-A novel tri-modular signaling system. Molecular Immunology, 45(4), 876-880. [More Information]
  • Amon, M., Ali, M., Manolios, N., Bender, V., Hall, K., Aguilar, M., Aldrich-Wright, J. (2008). Kinetic and conformational properties of a novel T-cell antigen receptor transmembrane peptide in model membranes. Journal of Peptide Science, 14, 714-724. [More Information]
  • Forchap, S., Anandacoomarasamy, A., Wicks, J., Di Virgilio, F., Baricordi, O., Rubbini, M., Trotta, F., Manolios, N. (2008). P2X gene polymorphisms do not appear to be a susceptibility gene locus in sporadic cases of systemic lupus erythematosus. Tissue Antigens: immune response genetics, 72(5), 487-490. [More Information]
  • Manolios, N., Ali, M., Amon, M., Bender, V. (2008). Therapeutic application of transmembrane T and natural killer cell receptor peptides. Advances in Experimental Medicine and Biology, 640, 208-219. [More Information]

2007

  • Chan, E., Amon, M., Marano, R., Wimmer, N., Kearns, P., Manolios, N., Rakoczy, P., Toth, I. (2007). Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. Bioorganic and Medicinal Chemistry, 15(12), 4091-4097. [More Information]
  • Ali, M., Manolios, N. (2007). Peptide-based therapies for arthritis. International Journal of Clinical Rheumatology, 2(3), 287-296. [More Information]
  • Ridda, I., MacIntyre, C., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, G., Kovoor, P., Manolios, N., Fox, J. (2007). Predictors of pneumococcal vaccination uptake in hospitalized patients aged 65 years and over shortly following the commencement of a publicly funded national pneumococcal vaccination program in Australia. Human Vaccines, 3(3), 57-60. [More Information]
  • Englert, H., Manolios, N., Kirkham, S. (2007). Reconstructive hand surgery for scleroderma joint contractures. Journal Of Hand Surgery (American volume), 32(7), 1107-1112. [More Information]
  • Kumar, V., Ali, M., Angelides, S., Manolios, N. (2007). Synthesis and characterization of 99mTc-Glucosamine & 99mTc-His-CP and evaluation of their utility in imaging inflammatory arthritis. Australian and New Zealand Nuclear Medicine, 38(3), 10-13.
  • Kurosaka, N., Bolte, A., Ali, M., Manolios, N. (2007). T-Cell Antigen Receptor Assembly and Cell Surface Expression Is Not Affected by Treatment with T-Cell Antigen Receptor-Alpha Chain Transmembrane Peptide. Protein and Peptide Letters, 14(3), 299-303. [More Information]
  • Kurosaka, N., Ali, M., Byth Wilson, K., Manolios, N. (2007). The mode of anti-arthritic peptide delivery impacts on the severity and outcome of adjuvant induced arthritis. APLAR Journal of Rheumatology, 10(3), 198-203. [More Information]

2006

  • Lindley, R., MacIntyre, R., Ridda, I., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). A new method of assessing frailty in older patients recruited into pneumonia vaccination trials. 5th International Symposium on Pneumococci and Pneumococcal Diseases, Australia: Abstract Book.
  • Lindley, R., MacIntyre, R., Ridda, I., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). A new method of assessing frailty in older patients recruited into randomised controlled trials. Australian Society for Geriatric Medicine Annual Scientific Meeting, Australia: Blackwell Publishers.
  • Al-Mashaleh, M., Packham, D., Manolios, N. (2006). Clinical Images: Bazin's Disease (Erythema Induratum). Journal of Rheumatology, 33(7), 1415. [More Information]
  • Collier, S., Bolte, A., Manolios, N. (2006). Discrepancy in CD3-Transmembrane Peptide Activity between In Vitro and In Vivo T-Cell Inhibition. Scandinavian Journal of Immunology, 64(4), 388-391. [More Information]
  • Manolios, N., Samaras, K. (2006). Hypercarotenaemia. Internal Medicine Journal, 36(8), 534. [More Information]
  • Vandebona, H., Ali, M., Amon, M., Bender, V., Manolios, N. (2006). Immunoreceptor transmembrane peptides and their effect on natural killer (NK) cell cytotoxicity. Protein and Peptide Letters, 13(10), 1017-1024. [More Information]
  • Russo, R., Medbury, H., Guiffre, A., Englert, H., Manolios, N. (2006). Lack of increased expression of cell surface markers for circulating fibrocyte progenitors in limited scleroderma. Clinical Rheumatology, 26(7), 1136-1141. [More Information]
  • Amon, M., Ali, M., Bender, V., Chan, Y., Toth, I., Manolios, N. (2006). Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hydrophobic peptide dramatically enhances in vitro and in vivo function. Biochimica et Biophysica Acta, 1763 (8), 879-888. [More Information]
  • Anandacoomarasamy, A., Peduto, A., Howe, G., Manolios, N. (2006). Magnetic resonance imaging in Lofgren's syndrome: demonstration of periarthritis. Clinical Rheumatology, 26, 572-5. [More Information]
  • Al-Mashaleh, M., Bak, H., Moore, J., Manolios, N., Englert, H. (2006). Resolution of sclerodermatous myocarditis after autologous stem cell transplantation. Annals of the Rheumatic Diseases, 65(9), 1247-8. [More Information]
  • Ali, M., Salam, N., Amon, M., Bender, V., Hibbs, D., Manolios, N. (2006). T-cell antigen receptor-alpha chain transmembrane peptides: correlation between structure and function. International Journal of Peptide Research and Therapeutics, 12(3), 261-267. [More Information]
  • Ridda, I., MacIntyre, R., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). Vaccination uptake in hospitalised geriatric patients 4-6 months after commencement of a funded national pneumococcal vaccination program for >65's. 5th International Symposium on Pneumococci and Pneumococcal Diseases, Australia: Abstract Book.
  • Ridda, I., MacIntyre, R., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). Vaccination uptake in hospitalised geriatric patients within the first year after commencement of a funded national pneumococcal vaccination program for > 65 year olds. Australian Society for Geriatric Medicine Annual Scientific Meeting, Australia: Blackwell Publishers.

2005

  • Anandacoomarasamy, A., Howe, G., Manolios, N. (2005). Advanced refractory polymyositis responding to infliximab. Rheumatology, 44(4), 562-3. [More Information]
  • Lim, I., Kefford, R., Manolios, N. (2005). Chemotherapeutic induced fascial oedema. Annals of the Rheumatic Diseases, 64(1), 162-163. [More Information]
  • Geevasinga, N., Jeremy, R., Crombie, C., Manolios, N. (2005). Histiocytosis and bone: experience from one major Sydney teaching hospital. Internal Medicine Journal, 35(10), 622-625. [More Information]
  • Ali, M., Manolios, N., Bender, V., Amon, M. (2005). Hydrophobic transmembrane-peptide lipid conjugations enhance membrane binding and functional activity in T-cells. Bioconjugate Chemistry, 16(6), 1556-63. [More Information]
  • Anandacoomarasamy, A., Bak, H., Peduto, A., Manolios, N. (2005). Magnetic resonance imaging in pachydermodactyly. Journal of Rheumatology, 32(11), 2239-41. [More Information]
  • Ali, M., Manolios, N. (2005). Proteomics in rheumatology: a new direction for old diseases. Seminars in Arthritis and Rheumatism, 35(2), 67-76. [More Information]
  • Englert, H., Joyner, J., Bade, R., Thompson, M., Morris, D., Chambers, P., Carroll, G., Manolios, N. (2005). Systemic scleroderma: a spatiotemporal clustering. Internal Medicine Journal, 35(4), 228-233. [More Information]

2004

  • Ali, M., Amon, M., Kurosaka, N., Manolios, N. (2004). Photoactive benzophenone labelled peptide. APLAR Journal of Rheumatology, 7(1), 11-12. [More Information]
  • Bender, V., Ali, M., Amon, M., Diefenbach, E., Manolios, N. (2004). T Cell Antigen Receptor Peptide-Lipid Membrane Interactions Using Surface Plasmon Resonance. Journal of Biological Chemistry, 279(52), 54002-54007. [More Information]

2003

  • Wong, P., Spencer, D., McElduff, P., Manolios, N., Larcos, G., Howe, G. (2003). Secondary screening for osteoporosis in patients admitted with minimal-trauma fracture to a major teaching hospital. Internal Medicine Journal, 33(11), 505-510. [More Information]
  • Huynh, N., Ffrench, R., Boadle, R., Manolios, N. (2003). Transmembrane T-cell receptor peptides inhibit B-and natural killer-cell function. Immunology, 108(4), 458-464. [More Information]

2002

  • Buhler, M., Craig, M., Donaghue, K., Badhwar, P., Willis, J., Manolios, N., Tait, B., Silink, M., Bennetts, B., Stewart, G. (2002). CCR5 Genotyping in an Australian and New Zealand type 1 Diabetes Cohort. Autoimmunity, 65(7), 457-461. [More Information]
  • Wang, X., Djordjevic, J., Kurosaka, N., Schibeci, S., Lee, K., Williamson, P., Manolios, N. (2002). T-Cell Antigen Receptor Peptides Inhibit Signal Transduction within the Membrane Bilayer. Clinical Immunology, 105(2), 199-207. [More Information]

2001

  • Hassett, G., Harnett, P., Manolios, N. (2001). Scleroderma in association with the use of docetaxel (taxotere) for breast cancer. Clinical and Experimental Rheumatology, 19, 197-200.

2000

  • Huang, Q., Teutsch, S., Buhler, M., Bennetts, B., Heard, R., Manolios, N., Stewart, G. (2000). Evaluation of the Apo-1/Fas promoter Mva 1 polymorphism in multiple sclerosis. Multiple Sclerosis: clinical and laboratory research, 6(1), 14-18.

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