Professor Nicholas Manolios

Professor
Medicine, Westmead Clinical School

Telephone +61 2 9845 6305
Fax +61 2 98458317

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Research interests

Professor Nicholas Manolios research interests are: (i) Structure and assembly of the T-cell antigen receptor, in particular, its role in the predisposition and causation of auto-immune and inflammatory rheumatic disorders, and (ii) Structure-function relationships of T cell assembly and T-cell activation, and how synthetic peptides may be used as therapeutic agents to suppress inflammation. Recent research hs focussed on drug delivery.

Selected grants

2010

  • Retroviral gene expression of immunosuppressive peptides in the prevention of islet transplantation rejection in mice.; Manolios N, Wong M; Wenkart Foundation/Scholarship.

2009

  • LP0989906, ARC Linkage - UWS Lead - Motherhood choices: a decision aid for women with rheumatoid ar; Manolios N, Sharpe L.
  • Application of a cyclic peptide (C1) for the treatment of T-cell mediated inflammatory disease; Manolios N; Royal Australasian College of Physicians/Specific Area Research Awards.
  • Peptide-Lipid interactions: Effect of cellular milieu on biophysical properties of transmembrane peptides; Manolios N; DVC Research/Bridging Support Grant.

2006

  • Not Known - To be advised; Manolios N; Rebecca L Cooper Medical Research Foundation/Medical Research Foundation.

2003

  • Natural Killer Cell Transmembrane Peptides - evaluation for Clinical Application; Manolios N, Kola R, Jonak Z; Glaxo SmithKline Aust Pty Ltd/BLO Project.

2002

  • Development of new anti-arthritic drugs; Manolios N; Clive & Vera Ramaciotti Foundation/Research Grants.

2000

  • Transgenomic WAVE 2100 denaturing HPLC system for DNA variant analysis; Farrell G, Clarke C, Cunningham A, deFazio A, Kirk J, Leary J, Liddle C, Manolios N, Mitchell P, Stewart G, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • T cell receptor peptide treatment in experimental allergic encephalomyelitis; Pollard J, Manolios N, Sander S; National Multiple Sclerosis Society of Australia/Project Grants.
  • Evaluation of specificity, mechanisms of action and therapeutic use of peptides that disrupt T-cell antigen receptor; Manolios N; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Efani, T., Manolios, N., Howe, G., Spencer, D. (2014). Acute gross painless transudative ascites in a patient with lupus. BMJ Case Reports, 17 January 2014, 1-2. [More Information]
  • Ali, M., Amon, M., Bender, V., Bolte, A., Separovic, F., Benson, H., Manolios, N. (2014). Cyclization enhances function of linear anti-arthritic peptides. Clinical Immunology, 150(1), 121-133. [More Information]
  • Wong, M., Tso, A., Ali, M., Hawthorne, W., Manolios, N. (2014). Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Diabetes & Metabolism, 40, 229-234. [More Information]
  • Vanniasinghe, A., Manolios, N., Schibeci, S., Lakhiani, C., Kamali-Sarvestani, E., Sharma, R., Kumar, V., Moghaddam, M., Ali, M., Bender, V. (2014). Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis. Clinical Immunology, 151(1), 43-54. [More Information]
  • Angelides, S., El-Mashaleh, M., Anagnostou, M., Howe, G., Spencer, D., Kumar, V., Manolios, N. (2014). The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience. Nuclear Medicine Communications, 35(6), 655-668. [More Information]
  • Meade (nee Covic), T., Cumming, S., Hallab, L., Spencer, D., Howe, G., Manolios, N. (2013). A preliminary investigation of cognitive function in rheumatoid arthritis patients on long term methotrexate treatment. Journal of Health Psychology, 18(10), 1353-1359. [More Information]
  • Raguine, L., Ali, M., Bender, V., Diefenbach, E., Doddareddy, M., Hibbs, D., Manolios, N. (2013). Alanine Scan of an Immunosuppressive Peptide (CP): Analysis of Structure-Function Relationships. Chemical Biology & Drug Design, 81(2), 167-174. [More Information]
  • Jordan, A., Spencer, D., Howe, G., Manolios, N. (2013). Cauda Equina Syndrome in Ankylosing Spondylitis. Journal of Clinical Rheumatology, 19(3), 163-163. [More Information]
  • Meade (nee Covic), T., Manolios, N. (2013). Cognitive function in rheumatoid arthritis. Arthritis Care and Research, 65(8), 1390-1390. [More Information]
  • Williams, A., Bloomfield, L., Milthorpe, E., Aspinall, D., Filocamo, K., Wellsmore, T., Manolios, N., Jayasinghe, U., Harris, M. (2013). Effectiveness of moving on: an Australian designed generic self-management program for people with a chronic illness. BMC Health Services Research, 13(1), 1-15. [More Information]
  • Manolios, N., Burneikis, A., Spencer, D., Howe, G. (2013). Failure of anti-TNF therapy to reactivate previously septic prosthetic joints. BMJ Case Reports, Article number 009827, 1-3. [More Information]
  • Meade (nee Covic), T., Sharpe, L., Hallab, L., Aspanell, D., Manolios, N. (2013). Navigating Motherhood Choices in the context of Rheumatoid Arthritis: Women's Stories. Musculoskeletal Care, 11(2), 73-82. [More Information]
  • Meade (nee Covic), T., Cumming, S., Pallant, J., Manolios, N., Emery, P., Conaghan, P., Tennant, A. (2012). Depression and Anxiety in Patients with Rheumatoid Arthritis: Prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the Hospital, Anxiety and Depression Scale (HADS). BMC Psychiatry, 12, 1-10. [More Information]
  • Tong, D., Manolios, N., Howe, G., Spencer, D. (2012). New onset sarcoid-like granulomatosis developing during anti-TNF therapy: an under-recognised complication. Internal Medicine Journal, 42(1), 89-94. [More Information]
  • Spencer, D., Howe, G., Manolios, N. (2012). No more excuses: fracture liaison services work and are cost-effective. Medical Journal of Australia, 196(6), 384-384. [More Information]
  • Ali, M., Vanniasinghe, A., Kumar, V., Barnett, R., Alberto, R., Manolios, N. (2011). 99mTc-technetium labeling of antiarthritic peptides to evaluate homing and biodistribution at inflamed joints. Nuclear Medicine and Biology, 38(5), 751-756. [More Information]
  • Lu, Y., Sharma, R., Ali, M., Byth Wilson, K., Manolios, N. (2011). Anti-Arthritic Effects of Immunomodulatory Peptide Injected in Joints. Current Drug Delivery, 8(6), 600-606. [More Information]
  • Zheng, G., Torres, A., Ali, M., Manolios, N., Price, W. (2011). NMR Study of the structure and self-association of core peptide in aqueous solution and DPC micelles. Biopolymers : Peptide Science, 96(2), 177-180. [More Information]
  • Otvos, L., Shao, W., Vanniasinghe, A., Amon, M., Holub, M., Kovalszky, I., Wade, J., Doll, M., Cohen, P., Manolios, N., et al (2011). Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides, 32(8), 1567-1574. [More Information]
  • Russo, R., Hughes, M., Manolios, N. (2010). Biopsy Diagnosis of Early Myositis Ossificans Without Radiologic Evidence of Calcification: Success of Early Surgical Resection. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 16(8), 385-7. [More Information]
  • Tong, D., Karunaratne, N., Howe, G., Spencer, D., Manolios, N. (2010). Clinical images: Calcifying pseudoneoplasm of the neuraxis. Arthritis and Rheumatism, 62(3), 704. [More Information]
  • Wong, M., Hawthorne, W., Manolios, N. (2010). Gene Therapy in Diabetes. Self Nonself, 1(3), 165-175. [More Information]
  • Tong, D., Murad, A., Manolios, N., Howe, G., Spencer, D. (2010). Pseudohypercalcaemia in mixed cryoglobulinaemia (IgMκ/polyclonal IgG): a rare complication of Sjögren's syndrome. Clinical Rheumatology, 29(4), 439-441. [More Information]
  • Manolios, N., Ali, M., Bender, V. (2010). T-cell antigen receptor (TCR) transmembrane peptides: A new paradigm for the treatment of autoimmune diseases. Cell adhesion & migration, 4(2), 273-83. [More Information]
  • Varatharajan, N., Lim, I., Anandacoomarasamy, A., Russo, R., Byth Wilson, K., Spencer, D., Manolios, N., Howe, G. (2009). Methotrexate: long-term safety and efficacy in an Australian consultant rheumatology practice. Internal Medicine Journal, 39(4), 228-236. [More Information]
  • Tong, D., Eather, S., Manolios, N. (2009). Psoriatic arthritis and chronic lymphoedema: treatment efficacy by adalimumab. Clinical Rheumatology, 28(11), 1349-1350. [More Information]
  • Vanniasinghe, A., Bender, V., Manolios, N. (2009). The Potential of Liposomal Drug Delivery for the Treatment of Inflammatory Arthritis. Seminars in Arthritis and Rheumatism, 39(3), 182-196. [More Information]
  • Englert, H., Kirkham, S., Moore, J., Poon, T., Katelaris, C., McGill, N., Schrieber, L., Manolios, N. (2008). Autologous stem cell transplantation in diffuse scleroderma: impact on hand structure and function. Internal Medicine Journal, 38(9), 692-696. [More Information]
  • Englert, H., Roberts-Thomson, P., Byth Wilson, K., Manolios, N. (2008). Familial scleroderma: nature, nurture or both? Internal Medicine Journal, 38(4), 235-242. [More Information]
  • Amon, M., Manolios, N. (2008). Hypothesis: TCR signal transduction-A novel tri-modular signaling system. Molecular Immunology, 45(4), 876-880. [More Information]
  • Amon, M., Ali, M., Manolios, N., Bender, V., Hall, K., Aguilar, M., Aldrich-Wright, J. (2008). Kinetic and conformational properties of a novel T-cell antigen receptor transmembrane peptide in model membranes. Journal of Peptide Science, 14, 714-724. [More Information]
  • Forchap, S., Anandacoomarasamy, A., Wicks, J., Di Virgilio, F., Baricordi, O., Rubbini, M., Trotta, F., Manolios, N. (2008). P2X gene polymorphisms do not appear to be a susceptibility gene locus in sporadic cases of systemic lupus erythematosus. Tissue Antigens: immune response genetics, 72(5), 487-490. [More Information]
  • Manolios, N., Ali, M., Amon, M., Bender, V. (2008). Therapeutic application of transmembrane T and natural killer cell receptor peptides. Advances in Experimental Medicine and Biology, 640, 208-219. [More Information]
  • Chan, E., Amon, M., Marano, R., Wimmer, N., Kearns, P., Manolios, N., Rakoczy, P., Toth, I. (2007). Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. Bioorganic and Medicinal Chemistry, 15(12), 4091-4097. [More Information]
  • Ali, M., Manolios, N. (2007). Peptide-based therapies for arthritis. International Journal of Clinical Rheumatology, 2(3), 287-296.
  • Ridda, I., MacIntyre, C., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, G., Kovoor, P., Manolios, N., Fox, J. (2007). Predictors of pneumococcal vaccination uptake in hospitalized patients aged 65 years and over shortly following the commencement of a publicly funded national pneumococcal vaccination program in Australia. Human Vaccines, 3(3), 57-60. [More Information]
  • Englert, H., Manolios, N., Kirkham, S. (2007). Reconstructive hand surgery for scleroderma joint contractures. Journal Of Hand Surgery (American Volume), 32(7), 1107-1112. [More Information]
  • Kumar, V., Ali, M., Angelides, S., Manolios, N. (2007). Synthesis and characterization of 99mTc-Glucosamine & 99mTc-His-CP and evaluation of their utility in imaging inflammatory arthritis. Australian and New Zealand Nuclear Medicine, 38(3), 10-13.
  • Kurosaka, N., Bolte, A., Ali, M., Manolios, N. (2007). T-Cell Antigen Receptor Assembly and Cell Surface Expression Is Not Affected by Treatment with T-Cell Antigen Receptor-Alpha Chain Transmembrane Peptide. Protein and Peptide Letters, 14(3), 299-303.
  • Kurosaka, N., Ali, M., Byth Wilson, K., Manolios, N. (2007). The mode of anti-arthritic peptide delivery impacts on the severity and outcome of adjuvant induced arthritis. APLAR Journal of Rheumatology, 10(3), 198-203.
  • Al-Mashaleh, M., Packham, D., Manolios, N. (2006). Clinical Images: Bazin's Disease (Erythema Induratum). Journal of Rheumatology, 33(7), 1415. [More Information]
  • Collier, S., Bolte, A., Manolios, N. (2006). Discrepancy in CD3-Transmembrane Peptide Activity between In Vitro and In Vivo T-Cell Inhibition. Scandinavian Journal of Immunology, 64(4), 388-391. [More Information]
  • Manolios, N., Samaras, K. (2006). Hypercarotenaemia. Internal Medicine Journal, 36(8), 534. [More Information]
  • Vandebona, H., Ali, M., Amon, M., Bender, V., Manolios, N. (2006). Immunoreceptor transmembrane peptides and their effect on natural killer (NK) cell cytotoxicity. Protein and Peptide Letters, 13(10), 1017-1024. [More Information]
  • Russo, R., Medbury, H., Guiffre, A., Englert, H., Manolios, N. (2006). Lack of increased expression of cell surface markers for circulating fibrocyte progenitors in limited scleroderma. Clinical Rheumatology, 26(7), 1136-1141. [More Information]
  • Amon, M., Ali, M., Bender, V., Chan, Y., Toth, I., Manolios, N. (2006). Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hydrophobic peptide dramatically enhances in vitro and in vivo function. BBA - Bioenergetics, 1763 (8), 879-888. [More Information]
  • Anandacoomarasamy, A., Peduto, A., Howe, G., Manolios, N. (2006). Magnetic resonance imaging in Lofgren's syndrome: demonstration of periarthritis. Clinical Rheumatology, 26, 572-5. [More Information]
  • Al-Mashaleh, M., Bak, H., Moore, J., Manolios, N., Englert, H. (2006). Resolution of sclerodermatous myocarditis after autologous stem cell transplantation. Annals of the Rheumatic Diseases, 65(9), 1247-8. [More Information]
  • Ali, M., Salam, N., Amon, M., Bender, V., Hibbs, D., Manolios, N. (2006). T-cell antigen receptor-alpha chain transmembrane peptides: correlation between structure and function. International Journal of Peptide Research and Therapeutics, 12(3), 261-267.
  • Anandacoomarasamy, A., Howe, G., Manolios, N. (2005). Advanced refractory polymyositis responding to infliximab. Rheumatology, 44(4), 562-3. [More Information]
  • Lim, I., Kefford, R., Manolios, N. (2005). Chemotherapeutic induced fascial oedema. Annals of the Rheumatic Diseases, 64(1), 162-163.
  • Geevasinga, N., Jeremy, R., Crombie, C., Manolios, N. (2005). Histiocytosis and bone: experience from one major Sydney teaching hospital. Internal Medicine Journal, 35(10), 622-625. [More Information]
  • Ali, M., Manolios, N., Bender, V., Amon, M. (2005). Hydrophobic transmembrane-peptide lipid conjugations enhance membrane binding and functional activity in T-cells. Bioconjugate Chemistry, 16(6), 1556-63. [More Information]
  • Anandacoomarasamy, A., Bak, H., Peduto, A., Manolios, N. (2005). Magnetic resonance imaging in pachydermodactyly. Journal of Rheumatology, 32(11), 2239-41. [More Information]
  • Ali, M., Manolios, N. (2005). Proteomics in rheumatology: a new direction for old diseases. Seminars in Arthritis and Rheumatism, 35(2), 67-76. [More Information]
  • Englert, H., Joyner, J., Bade, R., Thompson, M., Morris, D., Chambers, P., Carroll, G., Manolios, N. (2005). Systemic scleroderma: a spatiotemporal clustering. Internal Medicine Journal, 35(4), 228-233. [More Information]
  • Ali, M., Amon, M., Kurosaka, N., Manolios, N. (2004). Photoactive benzophenone labelled peptide. APLAR Journal of Rheumatology, 7(1), 11-12.
  • Bender, V., Ali, M., Amon, M., Diefenbach, E., Manolios, N. (2004). T Cell Antigen Receptor Peptide-Lipid Membrane Interactions Using Surface Plasmon Resonance. Journal of Biological Chemistry, 279(52), 54002-54007.
  • Wong, P., Spencer, D., McElduff, P., Manolios, N., Larcos, G., Howe, G. (2003). Secondary screening for osteoporosis in patients admitted with minimal-trauma fracture to a major teaching hospital. Internal Medicine Journal, 33(11), 505-510.
  • Huynh, N., Ffrench, R., Boadle, R., Manolios, N. (2003). Transmembrane T-cell receptor peptides inhibit B-and natural killer-cell function. Immunology, 108(4), 458-464.
  • Buhler, M., Craig, M., Donaghue, K., Badhwar, P., Willis, J., Manolios, N., Tait, B., Silink, M., Bennetts, B., Stewart, G. (2002). CCR5 Genotyping in an Australian and New Zealand type 1 Diabetes Cohort. Autoimmunity, 65(7), 457-461.
  • Wang, X., Djordjevic, J., Kurosaka, N., Schibeci, S., Lee, K., Williamson, P., Manolios, N. (2002). T-Cell Antigen Receptor Peptides Inhibit Signal Transduction within the Membrane Bilayer. Clinical Immunology, 105(2), 199-207. [More Information]
  • Hassett, G., Harnett, P., Manolios, N. (2001). Scleroderma in association with the use of docetaxel (taxotere) for breast cancer. Clinical and Experimental Rheumatology, 19, 197-200.
  • Huang, Q., Teutsch, S., Buhler, M., Bennetts, B., Heard, R., Manolios, N., Stewart, G. (2000). Evaluation of the Apo-1/Fas promoter Mva 1 polymorphism in multiple sclerosis. Multiple Sclerosis: clinical and laboratory research, 6(1), 14-18.

Conferences

  • Lindley, R., MacIntyre, R., Ridda, I., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). A new method of assessing frailty in older patients recruited into pneumonia vaccination trials. 5th International Symposium on Pneumococci and Pneumococcal Diseases, Australia: Abstract Book.
  • Lindley, R., MacIntyre, R., Ridda, I., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). A new method of assessing frailty in older patients recruited into randomised controlled trials. Australian Society for Geriatric Medicine Annual Scientific Meeting, Australia: Blackwell Publishers.
  • Ridda, I., MacIntyre, R., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). Vaccination uptake in hospitalised geriatric patients 4-6 months after commencement of a funded national pneumococcal vaccination program for >65's. 5th International Symposium on Pneumococci and Pneumococcal Diseases, Australia: Abstract Book.
  • Ridda, I., MacIntyre, R., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). Vaccination uptake in hospitalised geriatric patients within the first year after commencement of a funded national pneumococcal vaccination program for > 65 year olds. Australian Society for Geriatric Medicine Annual Scientific Meeting, Australia: Blackwell Publishers.

2014

  • Efani, T., Manolios, N., Howe, G., Spencer, D. (2014). Acute gross painless transudative ascites in a patient with lupus. BMJ Case Reports, 17 January 2014, 1-2. [More Information]
  • Ali, M., Amon, M., Bender, V., Bolte, A., Separovic, F., Benson, H., Manolios, N. (2014). Cyclization enhances function of linear anti-arthritic peptides. Clinical Immunology, 150(1), 121-133. [More Information]
  • Wong, M., Tso, A., Ali, M., Hawthorne, W., Manolios, N. (2014). Novel T-cell inhibiting peptides delay the onset of Type 1 diabetes in non-obese diabetic mice. Diabetes & Metabolism, 40, 229-234. [More Information]
  • Vanniasinghe, A., Manolios, N., Schibeci, S., Lakhiani, C., Kamali-Sarvestani, E., Sharma, R., Kumar, V., Moghaddam, M., Ali, M., Bender, V. (2014). Targeting fibroblast-like synovial cells at sites of inflammation with peptide targeted liposomes results in inhibition of experimental arthritis. Clinical Immunology, 151(1), 43-54. [More Information]
  • Angelides, S., El-Mashaleh, M., Anagnostou, M., Howe, G., Spencer, D., Kumar, V., Manolios, N. (2014). The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience. Nuclear Medicine Communications, 35(6), 655-668. [More Information]

2013

  • Meade (nee Covic), T., Cumming, S., Hallab, L., Spencer, D., Howe, G., Manolios, N. (2013). A preliminary investigation of cognitive function in rheumatoid arthritis patients on long term methotrexate treatment. Journal of Health Psychology, 18(10), 1353-1359. [More Information]
  • Raguine, L., Ali, M., Bender, V., Diefenbach, E., Doddareddy, M., Hibbs, D., Manolios, N. (2013). Alanine Scan of an Immunosuppressive Peptide (CP): Analysis of Structure-Function Relationships. Chemical Biology & Drug Design, 81(2), 167-174. [More Information]
  • Jordan, A., Spencer, D., Howe, G., Manolios, N. (2013). Cauda Equina Syndrome in Ankylosing Spondylitis. Journal of Clinical Rheumatology, 19(3), 163-163. [More Information]
  • Meade (nee Covic), T., Manolios, N. (2013). Cognitive function in rheumatoid arthritis. Arthritis Care and Research, 65(8), 1390-1390. [More Information]
  • Williams, A., Bloomfield, L., Milthorpe, E., Aspinall, D., Filocamo, K., Wellsmore, T., Manolios, N., Jayasinghe, U., Harris, M. (2013). Effectiveness of moving on: an Australian designed generic self-management program for people with a chronic illness. BMC Health Services Research, 13(1), 1-15. [More Information]
  • Manolios, N., Burneikis, A., Spencer, D., Howe, G. (2013). Failure of anti-TNF therapy to reactivate previously septic prosthetic joints. BMJ Case Reports, Article number 009827, 1-3. [More Information]
  • Meade (nee Covic), T., Sharpe, L., Hallab, L., Aspanell, D., Manolios, N. (2013). Navigating Motherhood Choices in the context of Rheumatoid Arthritis: Women's Stories. Musculoskeletal Care, 11(2), 73-82. [More Information]

2012

  • Meade (nee Covic), T., Cumming, S., Pallant, J., Manolios, N., Emery, P., Conaghan, P., Tennant, A. (2012). Depression and Anxiety in Patients with Rheumatoid Arthritis: Prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the Hospital, Anxiety and Depression Scale (HADS). BMC Psychiatry, 12, 1-10. [More Information]
  • Tong, D., Manolios, N., Howe, G., Spencer, D. (2012). New onset sarcoid-like granulomatosis developing during anti-TNF therapy: an under-recognised complication. Internal Medicine Journal, 42(1), 89-94. [More Information]
  • Spencer, D., Howe, G., Manolios, N. (2012). No more excuses: fracture liaison services work and are cost-effective. Medical Journal of Australia, 196(6), 384-384. [More Information]

2011

  • Ali, M., Vanniasinghe, A., Kumar, V., Barnett, R., Alberto, R., Manolios, N. (2011). 99mTc-technetium labeling of antiarthritic peptides to evaluate homing and biodistribution at inflamed joints. Nuclear Medicine and Biology, 38(5), 751-756. [More Information]
  • Lu, Y., Sharma, R., Ali, M., Byth Wilson, K., Manolios, N. (2011). Anti-Arthritic Effects of Immunomodulatory Peptide Injected in Joints. Current Drug Delivery, 8(6), 600-606. [More Information]
  • Zheng, G., Torres, A., Ali, M., Manolios, N., Price, W. (2011). NMR Study of the structure and self-association of core peptide in aqueous solution and DPC micelles. Biopolymers : Peptide Science, 96(2), 177-180. [More Information]
  • Otvos, L., Shao, W., Vanniasinghe, A., Amon, M., Holub, M., Kovalszky, I., Wade, J., Doll, M., Cohen, P., Manolios, N., et al (2011). Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides, 32(8), 1567-1574. [More Information]

2010

  • Russo, R., Hughes, M., Manolios, N. (2010). Biopsy Diagnosis of Early Myositis Ossificans Without Radiologic Evidence of Calcification: Success of Early Surgical Resection. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 16(8), 385-7. [More Information]
  • Tong, D., Karunaratne, N., Howe, G., Spencer, D., Manolios, N. (2010). Clinical images: Calcifying pseudoneoplasm of the neuraxis. Arthritis and Rheumatism, 62(3), 704. [More Information]
  • Wong, M., Hawthorne, W., Manolios, N. (2010). Gene Therapy in Diabetes. Self Nonself, 1(3), 165-175. [More Information]
  • Tong, D., Murad, A., Manolios, N., Howe, G., Spencer, D. (2010). Pseudohypercalcaemia in mixed cryoglobulinaemia (IgMκ/polyclonal IgG): a rare complication of Sjögren's syndrome. Clinical Rheumatology, 29(4), 439-441. [More Information]
  • Manolios, N., Ali, M., Bender, V. (2010). T-cell antigen receptor (TCR) transmembrane peptides: A new paradigm for the treatment of autoimmune diseases. Cell adhesion & migration, 4(2), 273-83. [More Information]

2009

  • Varatharajan, N., Lim, I., Anandacoomarasamy, A., Russo, R., Byth Wilson, K., Spencer, D., Manolios, N., Howe, G. (2009). Methotrexate: long-term safety and efficacy in an Australian consultant rheumatology practice. Internal Medicine Journal, 39(4), 228-236. [More Information]
  • Tong, D., Eather, S., Manolios, N. (2009). Psoriatic arthritis and chronic lymphoedema: treatment efficacy by adalimumab. Clinical Rheumatology, 28(11), 1349-1350. [More Information]
  • Vanniasinghe, A., Bender, V., Manolios, N. (2009). The Potential of Liposomal Drug Delivery for the Treatment of Inflammatory Arthritis. Seminars in Arthritis and Rheumatism, 39(3), 182-196. [More Information]

2008

  • Englert, H., Kirkham, S., Moore, J., Poon, T., Katelaris, C., McGill, N., Schrieber, L., Manolios, N. (2008). Autologous stem cell transplantation in diffuse scleroderma: impact on hand structure and function. Internal Medicine Journal, 38(9), 692-696. [More Information]
  • Englert, H., Roberts-Thomson, P., Byth Wilson, K., Manolios, N. (2008). Familial scleroderma: nature, nurture or both? Internal Medicine Journal, 38(4), 235-242. [More Information]
  • Amon, M., Manolios, N. (2008). Hypothesis: TCR signal transduction-A novel tri-modular signaling system. Molecular Immunology, 45(4), 876-880. [More Information]
  • Amon, M., Ali, M., Manolios, N., Bender, V., Hall, K., Aguilar, M., Aldrich-Wright, J. (2008). Kinetic and conformational properties of a novel T-cell antigen receptor transmembrane peptide in model membranes. Journal of Peptide Science, 14, 714-724. [More Information]
  • Forchap, S., Anandacoomarasamy, A., Wicks, J., Di Virgilio, F., Baricordi, O., Rubbini, M., Trotta, F., Manolios, N. (2008). P2X gene polymorphisms do not appear to be a susceptibility gene locus in sporadic cases of systemic lupus erythematosus. Tissue Antigens: immune response genetics, 72(5), 487-490. [More Information]
  • Manolios, N., Ali, M., Amon, M., Bender, V. (2008). Therapeutic application of transmembrane T and natural killer cell receptor peptides. Advances in Experimental Medicine and Biology, 640, 208-219. [More Information]

2007

  • Chan, E., Amon, M., Marano, R., Wimmer, N., Kearns, P., Manolios, N., Rakoczy, P., Toth, I. (2007). Novel cationic lipophilic peptides for oligodeoxynucleotide delivery. Bioorganic and Medicinal Chemistry, 15(12), 4091-4097. [More Information]
  • Ali, M., Manolios, N. (2007). Peptide-based therapies for arthritis. International Journal of Clinical Rheumatology, 2(3), 287-296.
  • Ridda, I., MacIntyre, C., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, G., Kovoor, P., Manolios, N., Fox, J. (2007). Predictors of pneumococcal vaccination uptake in hospitalized patients aged 65 years and over shortly following the commencement of a publicly funded national pneumococcal vaccination program in Australia. Human Vaccines, 3(3), 57-60. [More Information]
  • Englert, H., Manolios, N., Kirkham, S. (2007). Reconstructive hand surgery for scleroderma joint contractures. Journal Of Hand Surgery (American Volume), 32(7), 1107-1112. [More Information]
  • Kumar, V., Ali, M., Angelides, S., Manolios, N. (2007). Synthesis and characterization of 99mTc-Glucosamine & 99mTc-His-CP and evaluation of their utility in imaging inflammatory arthritis. Australian and New Zealand Nuclear Medicine, 38(3), 10-13.
  • Kurosaka, N., Bolte, A., Ali, M., Manolios, N. (2007). T-Cell Antigen Receptor Assembly and Cell Surface Expression Is Not Affected by Treatment with T-Cell Antigen Receptor-Alpha Chain Transmembrane Peptide. Protein and Peptide Letters, 14(3), 299-303.
  • Kurosaka, N., Ali, M., Byth Wilson, K., Manolios, N. (2007). The mode of anti-arthritic peptide delivery impacts on the severity and outcome of adjuvant induced arthritis. APLAR Journal of Rheumatology, 10(3), 198-203.

2006

  • Lindley, R., MacIntyre, R., Ridda, I., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). A new method of assessing frailty in older patients recruited into pneumonia vaccination trials. 5th International Symposium on Pneumococci and Pneumococcal Diseases, Australia: Abstract Book.
  • Lindley, R., MacIntyre, R., Ridda, I., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). A new method of assessing frailty in older patients recruited into randomised controlled trials. Australian Society for Geriatric Medicine Annual Scientific Meeting, Australia: Blackwell Publishers.
  • Al-Mashaleh, M., Packham, D., Manolios, N. (2006). Clinical Images: Bazin's Disease (Erythema Induratum). Journal of Rheumatology, 33(7), 1415. [More Information]
  • Collier, S., Bolte, A., Manolios, N. (2006). Discrepancy in CD3-Transmembrane Peptide Activity between In Vitro and In Vivo T-Cell Inhibition. Scandinavian Journal of Immunology, 64(4), 388-391. [More Information]
  • Manolios, N., Samaras, K. (2006). Hypercarotenaemia. Internal Medicine Journal, 36(8), 534. [More Information]
  • Vandebona, H., Ali, M., Amon, M., Bender, V., Manolios, N. (2006). Immunoreceptor transmembrane peptides and their effect on natural killer (NK) cell cytotoxicity. Protein and Peptide Letters, 13(10), 1017-1024. [More Information]
  • Russo, R., Medbury, H., Guiffre, A., Englert, H., Manolios, N. (2006). Lack of increased expression of cell surface markers for circulating fibrocyte progenitors in limited scleroderma. Clinical Rheumatology, 26(7), 1136-1141. [More Information]
  • Amon, M., Ali, M., Bender, V., Chan, Y., Toth, I., Manolios, N. (2006). Lipidation and glycosylation of a T cell antigen receptor (TCR) transmembrane hydrophobic peptide dramatically enhances in vitro and in vivo function. BBA - Bioenergetics, 1763 (8), 879-888. [More Information]
  • Anandacoomarasamy, A., Peduto, A., Howe, G., Manolios, N. (2006). Magnetic resonance imaging in Lofgren's syndrome: demonstration of periarthritis. Clinical Rheumatology, 26, 572-5. [More Information]
  • Al-Mashaleh, M., Bak, H., Moore, J., Manolios, N., Englert, H. (2006). Resolution of sclerodermatous myocarditis after autologous stem cell transplantation. Annals of the Rheumatic Diseases, 65(9), 1247-8. [More Information]
  • Ali, M., Salam, N., Amon, M., Bender, V., Hibbs, D., Manolios, N. (2006). T-cell antigen receptor-alpha chain transmembrane peptides: correlation between structure and function. International Journal of Peptide Research and Therapeutics, 12(3), 261-267.
  • Ridda, I., MacIntyre, R., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). Vaccination uptake in hospitalised geriatric patients 4-6 months after commencement of a funded national pneumococcal vaccination program for >65's. 5th International Symposium on Pneumococci and Pneumococcal Diseases, Australia: Abstract Book.
  • Ridda, I., MacIntyre, R., Lindley, R., McIntyre, P., Sullivan, J., Gilbert, L., Koovor, P., Manolios, N. (2006). Vaccination uptake in hospitalised geriatric patients within the first year after commencement of a funded national pneumococcal vaccination program for > 65 year olds. Australian Society for Geriatric Medicine Annual Scientific Meeting, Australia: Blackwell Publishers.

2005

  • Anandacoomarasamy, A., Howe, G., Manolios, N. (2005). Advanced refractory polymyositis responding to infliximab. Rheumatology, 44(4), 562-3. [More Information]
  • Lim, I., Kefford, R., Manolios, N. (2005). Chemotherapeutic induced fascial oedema. Annals of the Rheumatic Diseases, 64(1), 162-163.
  • Geevasinga, N., Jeremy, R., Crombie, C., Manolios, N. (2005). Histiocytosis and bone: experience from one major Sydney teaching hospital. Internal Medicine Journal, 35(10), 622-625. [More Information]
  • Ali, M., Manolios, N., Bender, V., Amon, M. (2005). Hydrophobic transmembrane-peptide lipid conjugations enhance membrane binding and functional activity in T-cells. Bioconjugate Chemistry, 16(6), 1556-63. [More Information]
  • Anandacoomarasamy, A., Bak, H., Peduto, A., Manolios, N. (2005). Magnetic resonance imaging in pachydermodactyly. Journal of Rheumatology, 32(11), 2239-41. [More Information]
  • Ali, M., Manolios, N. (2005). Proteomics in rheumatology: a new direction for old diseases. Seminars in Arthritis and Rheumatism, 35(2), 67-76. [More Information]
  • Englert, H., Joyner, J., Bade, R., Thompson, M., Morris, D., Chambers, P., Carroll, G., Manolios, N. (2005). Systemic scleroderma: a spatiotemporal clustering. Internal Medicine Journal, 35(4), 228-233. [More Information]

2004

  • Ali, M., Amon, M., Kurosaka, N., Manolios, N. (2004). Photoactive benzophenone labelled peptide. APLAR Journal of Rheumatology, 7(1), 11-12.
  • Bender, V., Ali, M., Amon, M., Diefenbach, E., Manolios, N. (2004). T Cell Antigen Receptor Peptide-Lipid Membrane Interactions Using Surface Plasmon Resonance. Journal of Biological Chemistry, 279(52), 54002-54007.

2003

  • Wong, P., Spencer, D., McElduff, P., Manolios, N., Larcos, G., Howe, G. (2003). Secondary screening for osteoporosis in patients admitted with minimal-trauma fracture to a major teaching hospital. Internal Medicine Journal, 33(11), 505-510.
  • Huynh, N., Ffrench, R., Boadle, R., Manolios, N. (2003). Transmembrane T-cell receptor peptides inhibit B-and natural killer-cell function. Immunology, 108(4), 458-464.

2002

  • Buhler, M., Craig, M., Donaghue, K., Badhwar, P., Willis, J., Manolios, N., Tait, B., Silink, M., Bennetts, B., Stewart, G. (2002). CCR5 Genotyping in an Australian and New Zealand type 1 Diabetes Cohort. Autoimmunity, 65(7), 457-461.
  • Wang, X., Djordjevic, J., Kurosaka, N., Schibeci, S., Lee, K., Williamson, P., Manolios, N. (2002). T-Cell Antigen Receptor Peptides Inhibit Signal Transduction within the Membrane Bilayer. Clinical Immunology, 105(2), 199-207. [More Information]

2001

  • Hassett, G., Harnett, P., Manolios, N. (2001). Scleroderma in association with the use of docetaxel (taxotere) for breast cancer. Clinical and Experimental Rheumatology, 19, 197-200.

2000

  • Huang, Q., Teutsch, S., Buhler, M., Bennetts, B., Heard, R., Manolios, N., Stewart, G. (2000). Evaluation of the Apo-1/Fas promoter Mva 1 polymorphism in multiple sclerosis. Multiple Sclerosis: clinical and laboratory research, 6(1), 14-18.

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