Dr Nicholas West

Research Fellow
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone 95656163
Fax 95656101

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Research interests

Dr. West is a Senior Research Officer at the Centenary Institute who studies the causative agent of tuberculosis, Mycobacterium tuberculosis, with the development of better vaccines and treatments, the goal of his research.

International links

United Kingdom

(Imperial College) Employed 2002 thru 2003

United Kingdom

(University of Oxford) Employed 2000 thru 2001

Selected grants

2012

  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Determining the bacterial contributions to tuberculosis and identification of drug targets; West N; National Health and Medical Research Council (NHMRC)/Career Development Awards.
  • Design, development and analysis of new tuberculosis drugs; West N, Britton W, Payne R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Genetic Basis of Ethionamide Resistance in Mycobacterium tuberculosis; West N; DVC International/IPDF Grant.

2010

  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Identifying genes for the control of Tuberculosis; West N; DVC Research/Bridging Support Grant.

2008

  • Regulation of pulmonary immune responses to subunit vaccines against tuberculosis; Britton W, Triccas J, West N; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Genome wide investigations of Mycobacterium tuberculosis to reveal processes of pathogenesis; West N; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Pinto, R., Leotta, L., Shanahan, E., West, N., Leyh, T., Britton, W., Triccas, J. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. The Journal of Infectious Diseases, 207(5), 778-785. [More Information]
  • Tran, A., Wen, D., West, N., Baker, E., Britton, W., Payne, R. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11(46), 8113-8126. [More Information]
  • Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]
  • Tran, A., West, N., Britton, W., Payne, R. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. ChemMedChem: chemistry enabling drug discovery, 7(6), 1031-1043. [More Information]
  • Manos-Turvey, A., Cergol, K., Salam, N., Bulloch, E., Chi, G., Pang, A., Britton, W., West, N., Baker, E., Lott, J., Payne, R. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10(46), 9223-9236. [More Information]
  • Kao, F., Mahmuda, S., Pinto, R., Triccas, J., West, N., Britton, W. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PloS One, 7(5), 1-12. [More Information]
  • West, N., Thomson, S., Triccas, J., Medveczky, C., Ramshaw, I., Britton, W. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29(44), 7759-7765. [More Information]
  • Triccas, J., Winter, N., Feng, C., West, N. (2011). Immunity to Mycobacterium tuberculosis. Clinical & Developmental Immunology, 2011, 406549-406549. [More Information]
  • West, N., Cergol, K., Xue, M., Randall, E., Britton, W., Payne, R. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47(18), 5166-5168. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and Evaluation of Potent Ene-yne inhibitors of type II Dehydroquinases as Tuberculosis Drug Leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Shanahan, E., Pinto (Pinto-Nadanachandran), R., Triccas, J., Britton, W., West, N. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28(5), 1341-1346. [More Information]
  • Crellin, P., Vivian, J., Scoble, J., Chow, F., West, N., Brammananth, R., Proellocks, N., Shahine, A., Le Nours, J., Wilce, M., Britton, W., et al (2010). Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability. Journal of Biological Chemistry, 285(39), 30050-30060. [More Information]
  • West, N., Chow, F., Randall, E., Wu, J., Chen, J., Ribeiro, J., Britton, W. (2009). Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification. The F A S E B Journal, 23(6), 1-11. [More Information]
  • West, N., Wozniak, T., Valenzuela, J., Feng, C., Sher, A., Ribeiro, J., Britton, W. (2008). Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine, 26(31), 3853-3859. [More Information]
  • Exley, R., Shaw, J., Mowe, E., Sun, Y., West, N., Williamson, M., Botto, M., Smith, H., Tang, C. (2005). Available carbon source influences the resistance of Neisseria meningitidis against complement. The Journal of Experimental Medicine, 201(10), 1637-1645. [More Information]

2013

  • Pinto, R., Leotta, L., Shanahan, E., West, N., Leyh, T., Britton, W., Triccas, J. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. The Journal of Infectious Diseases, 207(5), 778-785. [More Information]
  • Tran, A., Wen, D., West, N., Baker, E., Britton, W., Payne, R. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11(46), 8113-8126. [More Information]
  • Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]

2012

  • Tran, A., West, N., Britton, W., Payne, R. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. ChemMedChem: chemistry enabling drug discovery, 7(6), 1031-1043. [More Information]
  • Manos-Turvey, A., Cergol, K., Salam, N., Bulloch, E., Chi, G., Pang, A., Britton, W., West, N., Baker, E., Lott, J., Payne, R. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10(46), 9223-9236. [More Information]
  • Kao, F., Mahmuda, S., Pinto, R., Triccas, J., West, N., Britton, W. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PloS One, 7(5), 1-12. [More Information]

2011

  • West, N., Thomson, S., Triccas, J., Medveczky, C., Ramshaw, I., Britton, W. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29(44), 7759-7765. [More Information]
  • Triccas, J., Winter, N., Feng, C., West, N. (2011). Immunity to Mycobacterium tuberculosis. Clinical & Developmental Immunology, 2011, 406549-406549. [More Information]
  • West, N., Cergol, K., Xue, M., Randall, E., Britton, W., Payne, R. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47(18), 5166-5168. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and Evaluation of Potent Ene-yne inhibitors of type II Dehydroquinases as Tuberculosis Drug Leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]

2010

  • Shanahan, E., Pinto (Pinto-Nadanachandran), R., Triccas, J., Britton, W., West, N. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28(5), 1341-1346. [More Information]
  • Crellin, P., Vivian, J., Scoble, J., Chow, F., West, N., Brammananth, R., Proellocks, N., Shahine, A., Le Nours, J., Wilce, M., Britton, W., et al (2010). Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability. Journal of Biological Chemistry, 285(39), 30050-30060. [More Information]

2009

  • West, N., Chow, F., Randall, E., Wu, J., Chen, J., Ribeiro, J., Britton, W. (2009). Cutinase-like proteins of Mycobacterium tuberculosis: characterization of their variable enzymatic functions and active site identification. The F A S E B Journal, 23(6), 1-11. [More Information]

2008

  • West, N., Wozniak, T., Valenzuela, J., Feng, C., Sher, A., Ribeiro, J., Britton, W. (2008). Immunological diversity within a family of cutinase-like proteins of Mycobacterium tuberculosis. Vaccine, 26(31), 3853-3859. [More Information]

2005

  • Exley, R., Shaw, J., Mowe, E., Sun, Y., West, N., Williamson, M., Botto, M., Smith, H., Tang, C. (2005). Available carbon source influences the resistance of Neisseria meningitidis against complement. The Journal of Experimental Medicine, 201(10), 1637-1645. [More Information]

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