Dr Nicolas Dzamko
Senior Research Fellow
Brain and Mind Centre
Central Clinical School
Member of the Brain and Mind Centre
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Biographical details
Nic Dzamko is a senior research fellow at the University of Sydney. Nic has a biomedical science degree with first class honours and a Chancellors letter of commendation from Flinders University of South Australia and a PhD from the University of Melbourne. Nic has trained at the Garvan Institute of Medical Research and at the MRC Protein Phosphorylation unit in Dundee, Scotland. Prior to joining the University of Sydney Nic was a NHMRC CJ Martin Fellowship holder in the Faculty of Medicine at the University of NSW and a conjoint research fellow at Neuroscience Research Australia.
Research interests
Our research group is trying to understand the causes of Parkinson's disease. In particular I focus on genetic causes of Parkinson's disease and whether the genes and proteins involved can be therapeutically targeted to treat Parkinson's disease, and/or be used as biomarkers for earlier diagnosis.
Current research students
Project title | Research student |
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LRRK2-mediated inflammation and Parkinson�s disease | Diba AHMADI RASTEGAR |
Characterisation of pre-clinical synucleinopathies | Jasmin GALPER |
Current projects
1. Understanding the biological function of LRRK2 phosphorylation sites.
2. LRRK2 expression in familial Parkinson's disease brain.
3. The effect of LRRK2 inhibitors on the differentiation of neural stem cells.
4. The contribution of TLR2 to alpha-synuclein pathology in Parkinson's disease.
5. The role of LRRK2 in inflammatory TLR signaling pathways.
6. Peripheral GBA activity in Parkinson's disease patients.
7. Rab phosphorylation in Parkinson's disease patient immune cells.
8. Inflammatory biomarkers for Parkinson's disease.
Selected grants
2018
- Assessing LRRK2, GCase and cytokines in cryopreserved monocytes; Robinson F, Dzamko N; Michael J Fox Foundation for Parkinsons Research/Research Support.
- Inflammatory phenotypes in differentiated human LRRK2 and GBA mutation IPS cell lines; Dzamko N; Michael J Fox Foundation for Parkinsons Research/Research Support.
- Lipidomics analysis using serum and CSF from LRRK2-associated Parkinson�s disease patients; Dzamko N, Kim W; Michael J Fox Foundation for Parkinsons Research/Research Support.
- Inflammatory markers in GBA carriers with and without PD; Dzamko N, Lewis S, Pope A, Halliday G; Michael J Fox Foundation for Parkinsons Research/Research Support.
2017
- How does LRRK2 activity effect TLR inflammatory signaling in human IPS-derived monocytes; Dzamko N; Michael J Fox Foundation for Parkinsons Research/Research Support.
- Peripheral Inflammatory cytokine profiling in Parkinson�s disease; Dzamko N, Halliday G; Michael J Fox Foundation for Parkinsons Research/Research Support.
2016
- Rab detection initiative; Dzamko N; Michael J Fox Foundation for Parkinsons Research/Research Support.
- Are their peripheral changes in GBA protein/activity in idiopathic Parkinson's disease patients; Halliday G, Lewis S, Dzamko N; Michael J Fox Foundation for Parkinsons Research/Research Support.
- Fluorescence tagging of endogenous LRRk2 to enable in vivo imaging in mice and IPS cells; Dzamko N; Michael J Fox Foundation for Parkinsons Research/Research Support.
Selected publications
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