Dr Nicole Carnt

NHMRC Early Career Fellow
Save Sight Institute


Curriculum vitae Curriculum vitae

Map

Biographical details

Nicole Carnt graduated from University of NSW in Optometry in 1989 and worked in private practice for 10 years before taking a position with the Brien Holden Vision Institute in 1999, where she held a variety of roles, including Principal Investigator on contact lens clinical trials. She completed a PhD on Epidemiology of Contact Lens Related Infection and Inflammation 2008-12, while working part time as a project manager at the UNSW and was awarded several research awards including two American Optometric Foundation Ezell Fellowships, the British Contact Lens Association Dallos Award 2010 and 2015 and the American Optometric Foundation Vistakon Research award 2011. She was awarded a National Health and Medical Research Centre CJ Martin Biomedical Fellowship Early Career Fellowship at Save Sight Institute, University of Sydney in 2012 and spent the first 2.5 years at Moorfields Eye Hospital, London, Europe’s largest tertiary eye hospital. Now back at Save Sight Institute, she is also affiliated with University College London and University of NSW.

Research interests

Her areas of research include the genetic susceptibility to cornea infection, anterior eye disease immunology, microbiology, epidemiology limbal stem cell diseaseand patient involvement in research.

Teaching and supervision

Vision science, optometry, microbilogy, immunology, eye infection and inflammation.

Current projects

Host immune response to bacterial keratitis: tear, corneal gene expression, genetics

Quality of life and economic impact of keratitis

Limbal stem cell dysfunction in contact lens wearers

Patient support and engagement in research

Associations

University College London, University of Liverpool, University of Leicester, Moorfields Eye Hospital, London, University of NSW, George Institutefor Global Health

Awards and honours

Jun, 2015-16: Investigating corneal limbal stem cell dysfunction in contact lens wearers, $3,500 Cornea & Contact Lens Association of Australia, with Clin Prof Stephanie Watson

May, 2015-16: Do CL packaging “No water” warning stickers improve contact lens compliance? US$18,260, Alcon Investigator Led Research Grant, with Mr Stephen Tuft

Nov 2014-15 A contemporary epidemiological case control study of Acanthamoeba Keratitis in the UK, £14,550, Fight for Sight Small Grant Award, with Prof John Dart and Dr Darwin Minassian

May 2014-15, The relationship between environmental sources and the susceptibility and severity of Acanthamoeba keratitis in the United Kingdom, £8,000, British Contact Lens Association (BCLA) Dallos Research Award, with Dr Simon Kilvington

Nov 2013-Mar 2014, Acanthameoba keratitis and corneal dystrophy research personnel support, £11,000, NIHR Research Capability Funding Grant with Mr Stephen Tuft

Nov 2013-Dec 2015, Genotyping the host immune profile in Acanthamoeba keratitis, £14,786, Fight for Sight Small Grant Award, with Prof John Dart and Prof Alison Hardcastle

Nov 2013-Dec 2015, Tear cytokine levels in contact lens wearers with Acanthamoeba keratitis, US$19,695, J&J VisioncareInvestigator Led Research Grant with Dr Virginia Calder and Prof John Dart

March 2013-14, Genetic Risk Factors for the susceptibility and severity of contact lens related Acanthamoeba Keratitis, £9,849, Fight for Sight Small Grant Award, UCL Institute of Ophthalmology with Prof John Dart

2012-16, Early Career Researcher CJ Martin Biomedical Research Fellowship, AU$433,000 National Health and Medical Research Council, Australian Government

2011-12 Association of interleukin 17 single nucleotide polymorphisms with the susceptibility and severity of corneal infection and inflammation, US$25,000, Vistakon Research Grant, American Optometric Foundation, with Prof Mark Willcox and Prof Fiona Stapleton

2012 Maki Shiobara Scholarship, AU$3,500 Optometric Vision Research Foundation, Australia

2010-11 & 2011-12 Contact lens wearer susceptibility to complications due to risk taking behaviour and genetics, AU$7,000, Cornea and Contact Lens Society of Australia Research Award

2010-11 & 2011-12 Ezell Fellow, US$19,000, American Optometric Foundation

2009-10, Risk taking behaviour: relationship with contact lens complications and compliance, £5,000, Dallos Research Award, British Contact Lens Association, with Prof Fiona Stapleton

2008-12, Contact lens wearer susceptibility to corneal infiltrative events due to risk taking behaviour and genetics, AU$96,653, Australian Postgraduate Award, Australian Government

In the media

Moorfields Eye Hospital NHS Foundation Trust Social Media Campaign: Healthy Contact lens wear (www.moorfields.nhs.uk/landing-page/healthy-habits-healthy-eyes; #naughtycornea

Patient and Public Involvement in Research

NIHR Moorfields/ UCL Biomedical Research Centre Cornea Acanthamoeba patient support and awareness program (2014) Acanthamoeba Keratitis patient-led Patient Information Leaflet; Patient and clinician focus group (April); BCLA Exhibition Stall: Improving compliance in CL wear; Research study: Do CL packaging “No water” warning stickers improve contact lens compliance

MHRA Informal Group on Contact Lens Related Infections_invited member (2014)

NIHR Moorfields/ UCL Biomedical Research Centre Cornea Patient Day (2013) Acanthamoeba Keratitis patient and carer research update and focus group exercise, London, Oct

James Lind Alliance/Fight for Sight Sight Loss and Vision Priority Setting Partnership (2013) Setting priorities for corneal and external eye diseases research workshop, Invited participant London, April

International links

United Kingdom

(UCL Institute of Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, UCL/Moorfields Biomedical Research Centre) Investigation of the host genetic immune response to Acanthamoeba Keratitis, diagnosis of bacterial keratitis, genetics of corneal dystrophies and patient involvement in research initiatives.

United Kingdom

(University of Leicester) Collaboration with Dr Simon Kilvington investigating the environmental influences on Acanthamoeba organisms

Selected grants

2012

  • Genetic eye disease; Carnt N; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Robaei, D., Carnt, N., Minassian, D., Dart, J. (2015). Therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis: risk factors, outcomes, and summary of the literature. Ophthalmology, 122(1), 17-24. [More Information]
  • Davidson, A., Cheong, S., Hysi, P., Venturini, C., Plagnol, V., Ruddle, J., Hala, A., Carnt, N., Gardner, J., Hassan, H., et al (2014). Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhauser syndrome and central corneal thickness. PloS One, 9(9), 1-12. [More Information]
  • Robaei, D., Carnt, N., Minassian, D., Dart, J. (2014). The Impact of Topical Corticosteroid Use before Diagnosis on the Outcome of Acanthamoeba Keratitis. Ophthalmology, 121(7), 1383-1388. [More Information]

2015

  • Robaei, D., Carnt, N., Minassian, D., Dart, J. (2015). Therapeutic and optical keratoplasty in the management of Acanthamoeba keratitis: risk factors, outcomes, and summary of the literature. Ophthalmology, 122(1), 17-24. [More Information]

2014

  • Davidson, A., Cheong, S., Hysi, P., Venturini, C., Plagnol, V., Ruddle, J., Hala, A., Carnt, N., Gardner, J., Hassan, H., et al (2014). Association of CHRDL1 mutations and variants with X-linked megalocornea, Neuhauser syndrome and central corneal thickness. PloS One, 9(9), 1-12. [More Information]
  • Robaei, D., Carnt, N., Minassian, D., Dart, J. (2014). The Impact of Topical Corticosteroid Use before Diagnosis on the Outcome of Acanthamoeba Keratitis. Ophthalmology, 121(7), 1383-1388. [More Information]

To update your profile click here. For support on your academic profile contact .