Dr Nicole Carnt
NHMRC Early Career Fellow
Save Sight Institute
|Curriculum vitae||Curriculum vitae|
Nicole Carnt graduated from University of NSW in Optometry in 1989 and worked in private practice for 10 years before taking a position with the Brien Holden Vision Institute in 1999, where she held a variety of roles, including Principal Investigator on contact lens clinical trials. She completed a PhD on Epidemiology of Contact Lens Related Infection and Inflammation 2008-12, while working part time as a project manager at the UNSW and was awarded several research awards including two American Optometric Foundation Ezell Fellowships, the British Contact Lens Association Dallos Award 2010 and 2015 and the American Optometric Foundation Vistakon Research award 2011. She was awarded a National Health and Medical Research Centre CJ Martin Biomedical Fellowship Early Career Fellowship at Save Sight Institute, University of Sydney in 2012 and spent the first 2.5 years at Moorfields Eye Hospital, London, Europe’s largest tertiary eye hospital. Now back at Save Sight Institute, she is also affiliated with University College London and University of NSW.
Her areas of research include the genetic susceptibility to cornea infection, anterior eye disease immunology, microbiology, epidemiology limbal stem cell diseaseand patient involvement in research.
Teaching and supervision
Vision science, optometry, microbilogy, immunology, eye infection and inflammation.
Host immune response to bacterial keratitis: tear, corneal gene expression, genetics
Quality of life and economic impact of keratitis
Limbal stem cell dysfunction in contact lens wearers
Patient support and engagement in research
University College London, University of Liverpool, University of Leicester, Moorfields Eye Hospital, London, University of NSW, George Institutefor Global Health
Awards and honours
2015-16 An investigation of the host immune reaction in response to corneal infection, US$60,000, American Optometric Foundation Allergan Research Award, with Clin Prof Stephanie Watson
2015 An in vivo study of the host immune response to corneal infection,AU$20,000 University of Sydney, Faculty of Medicine, Kickstart Award
Jun, 2015-16: Investigating corneal limbal stem cell dysfunction in contact lens wearers, $3,500 Cornea & Contact Lens Association of Australia, with Clin Prof Stephanie Watson
Nov 2014-15 A contemporary epidemiological case control study of Acanthamoeba Keratitis in the UK, £14,550, Fight for Sight Small Grant Award, with Prof John Dart and Dr Darwin Minassian
May 2014-15, The relationship between environmental sources and the susceptibility and severity of Acanthamoeba keratitis in the United Kingdom, £8,000, British Contact Lens Association (BCLA) Dallos Research Award, with Dr Simon Kilvington
Nov 2013-Mar 2014, Acanthameoba keratitis and corneal dystrophy research personnel support, £11,000, NIHR Research Capability Funding Grant with Mr Stephen Tuft
Nov 2013-Dec 2015, Genotyping the host immune profile in Acanthamoeba keratitis, £14,786, Fight for Sight Small Grant Award, with Prof John Dart and Prof Alison Hardcastle
Nov 2013-Dec 2015, Tear cytokine levels in contact lens wearers with Acanthamoeba keratitis, US$19,695, J&J VisioncareInvestigator Led Research Grant with Dr Virginia Calder and Prof John Dart
March 2013-14, Genetic Risk Factors for the susceptibility and severity of contact lens related Acanthamoeba Keratitis, £9,849, Fight for Sight Small Grant Award, UCL Institute of Ophthalmology with Prof John Dart
2012-16, Early Career Researcher CJ Martin Biomedical Research Fellowship, AU$433,000 National Health and Medical Research Council, Australian Government
2011-12 Association of interleukin 17 single nucleotide polymorphisms with the susceptibility and severity of corneal infection and inflammation, US$25,000, Vistakon Research Grant, American Optometric Foundation, with Prof Mark Willcox and Prof Fiona Stapleton
2012 Maki Shiobara Scholarship, AU$3,500 Optometric Vision Research Foundation, Australia
2010-11 & 2011-12 Contact lens wearer susceptibility to complications due to risk taking behaviour and genetics, AU$7,000, Cornea and Contact Lens Society of Australia Research Award
2010-11 & 2011-12 Ezell Fellow, US$19,000, American Optometric Foundation
2009-10, Risk taking behaviour: relationship with contact lens complications and compliance, £5,000, Dallos Research Award, British Contact Lens Association, with Prof Fiona Stapleton
2008-12, Contact lens wearer susceptibility to corneal infiltrative events due to risk taking behaviour and genetics, AU$96,653, Australian Postgraduate Award, Australian Government
In the media
Moorfields Eye Hospital NHS Foundation Trust Social Media Campaign: Healthy Contact lens wear (www.moorfields.nhs.uk/landing-page/healthy-habits-healthy-eyes; #naughtycornea
Patient and Public Involvement in Research
NIHR Moorfields/ UCL Biomedical Research Centre Cornea Acanthamoeba patient support and awareness program (2014) Acanthamoeba Keratitis patient-led Patient Information Leaflet; Patient and clinician focus group (April); BCLA Exhibition Stall: Improving compliance in CL wear; Research study: Do CL packaging “No water” warning stickers improve contact lens compliance
MHRA Informal Group on Contact Lens Related Infections_invited member (2014)
NIHR Moorfields/ UCL Biomedical Research Centre Cornea Patient Day (2013) Acanthamoeba Keratitis patient and carer research update and focus group exercise, London, Oct
James Lind Alliance/Fight for Sight Sight Loss and Vision Priority Setting Partnership (2013) Setting priorities for corneal and external eye diseases research workshop, Invited participant London, April
(UCL Institute of Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, UCL/Moorfields Biomedical Research Centre)
Investigation of the host genetic immune response to Acanthamoeba Keratitis, diagnosis of bacterial keratitis, genetics of corneal dystrophies and patient involvement in research initiatives.
(University of Leicester)
Collaboration with Dr Simon Kilvington investigating the environmental influences on Acanthamoeba organisms
- Understanding the immune response to eye infections: The hope for limiting sight threatening tissue damage; Carnt N; DVC Research/Laffan Fellowships.
- An investigation of the host immune reaction in response to corneal infection; Carnt N, Watson S; American Optometric Foundation/Allergan Foundation Research Grant.
- Investigation corneal limbal stem cell dysfunction in contact lens wearers; Carnt N; Cornea and Contact Lens Society of Australia/Research Award.
- Genetic eye disease; Carnt N; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.