Associate Professor Nikolas Haass

Honorary Associate Professor
Dermatology, Central Clinical School

Telephone +61 7 3443 7087
Fax +61 7 3443 6966

Curriculum vitae Curriculum vitae

Map

Biographical details

Current positions:

Associate Professor for Cutaneous Oncology, Principal Research Fellow

University of Queensland Diamantina Institute/Translational Research Institute

Department of Dermatology, Princess Alexandra Hospital, School of Medicine, Faculty of Health Sciences

University of Queensland, Brisbane, QLD, Australia

Honorary Associate Professor

Discipline of Dermatology, Central Clinical School

University of Sydney, Sydney, NSW, Australia

Adjunct Associate Faculty, Group Leader “Experimental Melanoma Therapy”

Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia

2007-2013:

Cameron Melanoma Research Fellow Senior Lecturer, Discipline of Dermatology/Royal Prince Alfred Hospital, The University of Sydney, NSW, Australia

Associate Faculty at the Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia.

2003-2007:

Postdoctoral Fellowship at the Wistar Institute, Philadelphia, PA, USA.

1999-2003:

Resident/registrar at the Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Germany.

1990-1998:

Medical School at the University of Heidelberg, Germany, and Doctoral thesis at the Department of Cell Biology, German Cancer Research Center, Heidelberg, Germany.

Research interests

A/Prof Nikolas Haass is a clinician scientist specializing in skin cancers. His interests is the understanding of (1) cell-cell and cell-matrix interactions of melanoma with its microenvironment (2) signalling pathways in melanoma, particularly with regards to identifying novel melanoma therapies and (3) the characterization of melanoma cell subpopulations. The techniques he uses include several three-dimensional cell culture models, which recreate the correct interactions of the melanoma with its tumour microenvironment and thus predict the effects of drugs on the tumour in a much better way than the conventional two-dimensional cell culture models. For his mouse models his team applies cutting-edge intravital multi-photon microscopy.

Publications:

**http://www.ncbi.nlm.nih.gov/pubmed/?term=haass+nk+or+haass+n**

Research Support:

1. Research Grant HA26801 (Postdoctoral Fellowship, N.K. Haass), German Research Foundation (DFG), 1/1/2004-6/30/2005

2. Cameron Melanoma Research Fellowship (N.K. Haass), Melanoma and Skin Cancer Research Institute (MASCRI), Melanoma Foundation/Dermatology Foundation, The University of Sydney, 10/01/2007-09/30/2012 ($ 825,000 for five years)

3. Project Grant RG 09-08 "The role of melanoma stem cells in melanomagenesis" (CIA N.K. Haass), Cancer Council New South Wales, 1/1/2009-12/31/2011 ($ 275,000 for three years)

4. Project Grant 570778 "The role of melanoma stem cells in melanomagenesis" (CIA N.K. Haass), Cure Cancer Australia Foundation, 1/1/2009-12/31/2009 ($ 75,000 for one year)

5. Research Innovation Grant 08/RFG/1-27 "Intravital cell-cycle imaging as a novel approach to design combined targeting strategies of independent signalling pathways in melanoma" (CIA N.K. Haass, CIB L.G. Ng), Cancer Institute New South Wales ($ 49,284 for one year)

6. Research Scholar Award 09/RSA/1-52 "Apoptosis pathways in the drug resistance and pathogenesis of melanoma" for PhD student Nethia Mohana-Kumaran, Cancer Institute New South Wales ($ 62,500)

7. ARC Discovery Grant DP1096674 "The biological and pathological functions of TDP-43" (CIA L.M. Ittner, CIB J. Götz, CIC N.K. Haass), ARC, 1/1/2010-12/31/2012 ($ 480,000 for three years)

8. NHMRC Project Grant 1003637 "Real-time Imaging of Cell Cycle Progression in Melanoma" (CIA N.K. Haass, CIB W. Weninger), NHMRC, 1/1/2011-12/31/2013 ($ 466,299 for three years)

9.Geoff & Jan Cook Melanoma Research Award to N.K. Haass ($ 15,557)

10. NHMRC Project Grant 1029260 “Synthetic lethality screen targeting a defective checkpoint in melanoma” (CIA B. Gabrielli, AI N.K. Haass), NHMRC, 1/1/2012-12/31/2014 ($ 533,675 for three years)

11. Sydney Medical School Foundation grant “Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy” (CIA N.K. Haass), ($ 11,000)

12. Project Grant RG 13-06 “Effect of three-dimensional tumour organisation on the sensitivity of individual melanoma cells to endoplasmic reticulum stress” (CIA N.K. Haass, CIB D.S. Hill, CIC W. Weninger), Cancer Council New South Wales, 1/1/2013-12/31/2015 ($ 359,673 for three years). This grant was chosen as one of the top ten CCNSW grants of the year.

13. Project Grant 1051996 “The role of Rab27a and Rab5a in melanoma phenotype switching” (CIA K.A. Beaumont, AI N.K. Haass), Priority-driven collaborative cancer research scheme/Cancer Australia/Cure Cancer Australia Foundation, 1/1/2013-12/31/2014 ($ 200,000 for two years)

Teaching and supervision

Skin cancer

Cancer cell biology

Cancer models and imaging

International links

Germany

(University of Hamburg) Collaboration in the cell-cell communication project

United States

(Moffitt Cancer Center) Collaboration in the Targeted Therapy project

United States

(The Wistar Institute) Collaboration in the Targeted Therapy project

United States

(University of Pennsylvania) Collaboration in the biomarker project

Selected grants

2013

  • Effect of three-dimensional tumour organisation on the sensitivity of individual melanoma cells to endoplasmic reticulum stress; Haass N, Beaumont K, Weninger W; Cancer Council New South Wales/Research Project Grants.

2011

  • Real-time Imaging of cell cycle progression in melanoma; Haass N, Weninger W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • High speed 3D live cell imaging of cancer genesis, growth, metastasis and death.; Weninger W, Vadas M, Richardson D, Fazekas B, Gamble J, McCaughan G, Rasko J, Shackel N, Haass N; Cancer Institute New South Wales/Equipment Grant.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Biological functions of the TAR DNA binding protein 43; Ittner L, Goetz J, Haass N; Australian Research Council (ARC)/Discovery Projects (DP).

2009

  • Intravital cell-cycle imaging as a novel approach to design combined targeting strategies of independant signaling pathways in melanoma; Haass N, Ng L; Cancer Institute New South Wales/Research Innovation Grants.
  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.
  • The Role of Melanoma Stem Cells in Melanomagnesis; Haass N; Cancer Council New South Wales/Research Project Grants.
  • The Role of Melanoma Stem Cells in Melanomagnesis; Haass N; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • Cameron Melanoma Research Fellow; Haass N; Melanoma and Skin Cancer Research Institute/Research Grant.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Kuphal, S., Haass, N. (2011). Cell–Cell and Cell–Matrix Contacts in Melanoma and the Tumor Microenvironment. In Anja Bosserhoff (Eds.), Melanoma Development: Molecular Biology, Genetics and Clinical Application, (pp. 181-215). Vienna: Springer.
  • Haass, N., Hoeller, C., Herlyn, M. (2008). Targeting Signaling Pathways - in the search of Melanoma's Achilles' heel. In Menashe Bar-Eli (Eds.), Regulation of Gene Expression in the Tumor Environment, (pp. 27-42). United States: Springer.

Journals

  • Beaumont, K., Kumaran - Mohana, N., Haass, N. (2014). Modeling Melanoma In Vitro and In Vivo. Healthcare, 2, 27-46. [More Information]
  • Stehn, J., Haass, N., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P., Sequeira, V., Butler, T., Allanson, M., Winlaw, D., Reeve, V., Weninger, W., et al (2013). A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells. Cancer Research, 73(16), 5169-5182. [More Information]
  • Tong, P., Qin, J., Cooper, C., Lowe, P., Murrell, D., Kossard, S., Ng, L., Roediger, B., Weninger, W., Haass, N. (2013). A quantitative approach to histopathological dissection of elastin-related disorders using multiphoton microscopy. British Journal of Dermatology, 169(4), 869-879. [More Information]
  • Pavey, S., Spoerri, L., Haass, N., Gabrielli, B. (2013). DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma. Pigment Cell and Melanoma Research, 26(6), 805-816. [More Information]
  • Brandner, J., Haass, N. (2013). Melanoma's connections to the tumour microenvironment. Pathology, 45(5), 443-452. [More Information]
  • Wroblewski, D., Mijatov, B., Mohana-Kumara, N., Lai, F., Gallagher, S., Haass, N., Zhang, X., Hersey, P. (2013). The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance. Carcinogenesis, 34(2), 237-247. [More Information]
  • Smalley, K., Aplin, A., Flaherty, K., Hoeller, C., Bosserhoff, A., Haass, N., Bosenberg, M., Ribas, A., Barnhill, R., Kudchadkar, R., et al (2012). Meeting report from the 2011 International Melanoma Congress, Tampa, Florida. Pigment Cell and Melanoma Research, 25(1), E1-E11. [More Information]
  • Lucas, K., Kumaran - Mohana, N., Lau, D., Zhang, X., Hersey, P., Huang, D., Weninger, W., Haass, N., Allen, J. (2012). Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737. Clinical Cancer Research, 18(3), 783-795. [More Information]
  • McGowan, E., Alling, N., Jackson, E., Yagoub, D., Haass, N., Allen, J., Martinello-Wilks, R. (2011). Evaluation of Cell Cycle Arrest in Estrogen Responsive MCF-7 Breast Cancer Cells: Pitfalls of the MTS Assay. PLoS One, 6(6), 1-8. [More Information]
  • Hersey, P., Smalley, K., Weeraratna, A., Bosenberg, M., Zhang, X., Haass, N., Paton, E., Mann, G., Scolyer, R. (2011). Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010. Pigment Cell and Melanoma Research, 24(1), e1-e15. [More Information]
  • de Zwaan, S., Haass, N. (2010). Genetics of basal cell carcinoma. Australasian Journal of Dermatology, 51(2), 81-92; quiz 93-4. [More Information]
  • Haass, N., Ripperger, D., Wladykowski, E., Dawson, P., Gimotty, P., Blome, C., Fischer, F., Schmage, P., Moll, I., Brandner, J. (2010). Melanoma progression exhibits a significant impact on connexin expression patterns in the epidermal tumor microenvironment. Histochemistry and Cell Biology, 133(1), 113-124. [More Information]
  • Cocciolone, R., Crotty, K., Andrews, L., Haass, N., Moloney, F. (2010). Multiple Desmoplastic Melanomas in Birt-Hogg-Dube Syndrome and a Proposed Signaling Link Between Folliculin, the mTOR Pathway, and Melanoma Susceptibility. Archives of Dermatology, 146(11), 1316-1318. [More Information]
  • Lee, J., Li, L., Brafford, P., van den Eijnden, M., Halloran, M., Sproesser, K., Haass, N., Smalley, K., Tsai, J., Bollag, G., et al (2010). PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas. Pigment Cell and Melanoma Research, 23(6), 820-827. [More Information]
  • Santiago-Walker, A., Li, L., Haass, N., Herlyn, M. (2009). Melanocytes: from morphology to application. Skin Pharmacology and Physiology, 22(2), 114-121. [More Information]
  • Haass, N., Smalley, K. (2009). Melanoma biomarkers: current status and utility in diagnosis, prognosis, and response to therapy. Molecular Diagnosis and Therapy, 13(5), 283-296. [More Information]
  • Tsai, J., Lee, J., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N., et al (2008). Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 105(8), 3041-3046. [More Information]
  • Haass, N. (2008). From xiphophorus to melanoma-a tribute to steven kazianis (1966-2008). Zebrafish, 5(2), 91-92. [More Information]
  • Smalley, K., Lioni, M., Noma, K., Haass, N., Herlyn, M. (2008). In vitro three-dimensional tumor microenvironment models for anticancer drug discovery. Expert Opinion on Drug Discovery, 3, 1-10. [More Information]
  • Haass, N., Sproesser, K., Nguyen, T., Contractor, R., Medina, C., Nathanson, K., Herlyn, M., Smalley, K. (2008). The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel. Clinical Cancer Research, 14(1), 230-239. [More Information]
  • Smalley, K., Contractor, R., Haass, N., Kulp, A., Atilla-Gokcumen, G., Williams, D., Bregman, H., Flaherty, K., Soengas, M., Meggers, E., et al (2007). An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. Cancer Research, 67(1), 209-217. [More Information]
  • Wenke, A., Kjellman, C., Lundgren-Akerlund, E., Uhlmann, C., Haass, N., Herlyn, M., Bosserhoff, A. (2007). Expression of integrin alpha10 is induced in malignant melanoma. Cellular Oncology, 29(5), 373-386. [More Information]
  • Smalley, K., Contractor, R., Haass, N., Lee, J., Nathanson, K., Medina, C., Flaherty, K., Herlyn, M. (2007). Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels. British Journal of Cancer, 96(3), 445-449. [More Information]
  • Haass, N., Wladykowski, E., Kief, S., Moll, I., Brandner, J. (2006). Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 54(2), 171-182. [More Information]
  • Smalley, K., Haass, N., Brafford, P., Lioni, M., Flaherty, K., Herlyn, M. (2006). Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Molecular Cancer Therapeutics, 5(5), 1136-1144. [More Information]
  • Haass, N., Smalley, K., Li, L., Herlyn, M. (2005). Adhesion, migration and communication in melanocytes and melanoma. Pigment Cell Research, 18(3), 150-159. [More Information]
  • Haass, N., Herlyn, M. (2005). Normal human melanocyte homeostasis as a paradigm for understanding melanoma. The journal of investigative dermatology. Symposium proceedings, 10(2), 153-163. [More Information]
  • Smalley, K., Brafford, P., Haass, N., Brandner, J., Brown, E., Herlyn, M. (2005). Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. The American Journal of Pathology: cellular and molecular biology of disease, 166(5), 1541-1554. [More Information]

Conferences

  • Coates, E., Moloney, F., Guitera, P., Haass, N., Ho, K., Khoury, R., Mann, G., Menzies, S. (2012). Melanoma detection in high risk patients: a case series. 20th Regional Conference of Dermatology 2012.
  • Moloney, F., Guitera, P., Coates, E., Haass, N., Ho, K., Khoury, R., Mann, G., Menzies, S. (2012). Observation of a five year high risk clinic for primary melanoma. 3rd World Congress of Dermoscopy, Australia.

2014

  • Beaumont, K., Kumaran - Mohana, N., Haass, N. (2014). Modeling Melanoma In Vitro and In Vivo. Healthcare, 2, 27-46. [More Information]

2013

  • Stehn, J., Haass, N., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P., Sequeira, V., Butler, T., Allanson, M., Winlaw, D., Reeve, V., Weninger, W., et al (2013). A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells. Cancer Research, 73(16), 5169-5182. [More Information]
  • Tong, P., Qin, J., Cooper, C., Lowe, P., Murrell, D., Kossard, S., Ng, L., Roediger, B., Weninger, W., Haass, N. (2013). A quantitative approach to histopathological dissection of elastin-related disorders using multiphoton microscopy. British Journal of Dermatology, 169(4), 869-879. [More Information]
  • Pavey, S., Spoerri, L., Haass, N., Gabrielli, B. (2013). DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma. Pigment Cell and Melanoma Research, 26(6), 805-816. [More Information]
  • Brandner, J., Haass, N. (2013). Melanoma's connections to the tumour microenvironment. Pathology, 45(5), 443-452. [More Information]
  • Wroblewski, D., Mijatov, B., Mohana-Kumara, N., Lai, F., Gallagher, S., Haass, N., Zhang, X., Hersey, P. (2013). The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance. Carcinogenesis, 34(2), 237-247. [More Information]

2012

  • Smalley, K., Aplin, A., Flaherty, K., Hoeller, C., Bosserhoff, A., Haass, N., Bosenberg, M., Ribas, A., Barnhill, R., Kudchadkar, R., et al (2012). Meeting report from the 2011 International Melanoma Congress, Tampa, Florida. Pigment Cell and Melanoma Research, 25(1), E1-E11. [More Information]
  • Coates, E., Moloney, F., Guitera, P., Haass, N., Ho, K., Khoury, R., Mann, G., Menzies, S. (2012). Melanoma detection in high risk patients: a case series. 20th Regional Conference of Dermatology 2012.
  • Lucas, K., Kumaran - Mohana, N., Lau, D., Zhang, X., Hersey, P., Huang, D., Weninger, W., Haass, N., Allen, J. (2012). Modulation of NOXA and MCL-1 as a Strategy for Sensitizing Melanoma Cells to the BH3-Mimetic ABT-737. Clinical Cancer Research, 18(3), 783-795. [More Information]
  • Moloney, F., Guitera, P., Coates, E., Haass, N., Ho, K., Khoury, R., Mann, G., Menzies, S. (2012). Observation of a five year high risk clinic for primary melanoma. 3rd World Congress of Dermoscopy, Australia.

2011

  • Kuphal, S., Haass, N. (2011). Cell–Cell and Cell–Matrix Contacts in Melanoma and the Tumor Microenvironment. In Anja Bosserhoff (Eds.), Melanoma Development: Molecular Biology, Genetics and Clinical Application, (pp. 181-215). Vienna: Springer.
  • McGowan, E., Alling, N., Jackson, E., Yagoub, D., Haass, N., Allen, J., Martinello-Wilks, R. (2011). Evaluation of Cell Cycle Arrest in Estrogen Responsive MCF-7 Breast Cancer Cells: Pitfalls of the MTS Assay. PLoS One, 6(6), 1-8. [More Information]
  • Hersey, P., Smalley, K., Weeraratna, A., Bosenberg, M., Zhang, X., Haass, N., Paton, E., Mann, G., Scolyer, R. (2011). Meeting report from the 7th International Melanoma Congress, Sydney, November, 2010. Pigment Cell and Melanoma Research, 24(1), e1-e15. [More Information]

2010

  • de Zwaan, S., Haass, N. (2010). Genetics of basal cell carcinoma. Australasian Journal of Dermatology, 51(2), 81-92; quiz 93-4. [More Information]
  • Haass, N., Ripperger, D., Wladykowski, E., Dawson, P., Gimotty, P., Blome, C., Fischer, F., Schmage, P., Moll, I., Brandner, J. (2010). Melanoma progression exhibits a significant impact on connexin expression patterns in the epidermal tumor microenvironment. Histochemistry and Cell Biology, 133(1), 113-124. [More Information]
  • Cocciolone, R., Crotty, K., Andrews, L., Haass, N., Moloney, F. (2010). Multiple Desmoplastic Melanomas in Birt-Hogg-Dube Syndrome and a Proposed Signaling Link Between Folliculin, the mTOR Pathway, and Melanoma Susceptibility. Archives of Dermatology, 146(11), 1316-1318. [More Information]
  • Lee, J., Li, L., Brafford, P., van den Eijnden, M., Halloran, M., Sproesser, K., Haass, N., Smalley, K., Tsai, J., Bollag, G., et al (2010). PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas. Pigment Cell and Melanoma Research, 23(6), 820-827. [More Information]

2009

  • Santiago-Walker, A., Li, L., Haass, N., Herlyn, M. (2009). Melanocytes: from morphology to application. Skin Pharmacology and Physiology, 22(2), 114-121. [More Information]
  • Haass, N., Smalley, K. (2009). Melanoma biomarkers: current status and utility in diagnosis, prognosis, and response to therapy. Molecular Diagnosis and Therapy, 13(5), 283-296. [More Information]

2008

  • Tsai, J., Lee, J., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N., et al (2008). Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 105(8), 3041-3046. [More Information]
  • Haass, N. (2008). From xiphophorus to melanoma-a tribute to steven kazianis (1966-2008). Zebrafish, 5(2), 91-92. [More Information]
  • Smalley, K., Lioni, M., Noma, K., Haass, N., Herlyn, M. (2008). In vitro three-dimensional tumor microenvironment models for anticancer drug discovery. Expert Opinion on Drug Discovery, 3, 1-10. [More Information]
  • Haass, N., Hoeller, C., Herlyn, M. (2008). Targeting Signaling Pathways - in the search of Melanoma's Achilles' heel. In Menashe Bar-Eli (Eds.), Regulation of Gene Expression in the Tumor Environment, (pp. 27-42). United States: Springer.
  • Haass, N., Sproesser, K., Nguyen, T., Contractor, R., Medina, C., Nathanson, K., Herlyn, M., Smalley, K. (2008). The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel. Clinical Cancer Research, 14(1), 230-239. [More Information]

2007

  • Smalley, K., Contractor, R., Haass, N., Kulp, A., Atilla-Gokcumen, G., Williams, D., Bregman, H., Flaherty, K., Soengas, M., Meggers, E., et al (2007). An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. Cancer Research, 67(1), 209-217. [More Information]
  • Wenke, A., Kjellman, C., Lundgren-Akerlund, E., Uhlmann, C., Haass, N., Herlyn, M., Bosserhoff, A. (2007). Expression of integrin alpha10 is induced in malignant melanoma. Cellular Oncology, 29(5), 373-386. [More Information]
  • Smalley, K., Contractor, R., Haass, N., Lee, J., Nathanson, K., Medina, C., Flaherty, K., Herlyn, M. (2007). Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels. British Journal of Cancer, 96(3), 445-449. [More Information]

2006

  • Haass, N., Wladykowski, E., Kief, S., Moll, I., Brandner, J. (2006). Differential induction of connexins 26 and 30 in skin tumors and their adjacent epidermis. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 54(2), 171-182. [More Information]
  • Smalley, K., Haass, N., Brafford, P., Lioni, M., Flaherty, K., Herlyn, M. (2006). Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Molecular Cancer Therapeutics, 5(5), 1136-1144. [More Information]

2005

  • Haass, N., Smalley, K., Li, L., Herlyn, M. (2005). Adhesion, migration and communication in melanocytes and melanoma. Pigment Cell Research, 18(3), 150-159. [More Information]
  • Haass, N., Herlyn, M. (2005). Normal human melanocyte homeostasis as a paradigm for understanding melanoma. The journal of investigative dermatology. Symposium proceedings, 10(2), 153-163. [More Information]
  • Smalley, K., Brafford, P., Haass, N., Brandner, J., Brown, E., Herlyn, M. (2005). Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. The American Journal of Pathology: cellular and molecular biology of disease, 166(5), 1541-1554. [More Information]

To update your profile click here. For support on your academic profile contact .