Dr Nitin Saksena

Senior Research Fellow
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 9119 / 9120/9124
Fax +61 2 845 9103

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Selected grants

2010

  • Determination of the diagnostic value of gag gene mutation at position 16 in HIV-1 for predicting below detectable levels of HIV during HAART; Wang B, Dwyer D, Saksena N; Australian Centre for Hepatitis and HIV Virology Research (ACH2)/Research Support.

2009

  • Real-time and quantitative monitoring of the emergence of oseltamivir resistance during the current influenza pandemic; Wang B, Saksena N, Dwyer D; National Health and Medical Research Council (NHMRC)/Special Call Research On H1N1 Influenza.

Selected publications

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Journals

  • Gupta, P., Liu, B., Wu, J., Soriano, V., Vispo, E., Carroll, A., Goldie, B., Cairns, M., Saksena, N. (2014). Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection. Virology, 450-451, 336-349. [More Information]
  • Gupta, P., Cairns, M., Saksena, N. (2014). Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma. Virology Journal, 11(1), 64- 1-64-14. [More Information]
  • Dube, S., Saksena, N., Spicer, T., Healey, J., Benz, P., Dube, D., Poiesz, B. (2013). Delayed seroconversion to STLV-1 infection is associated with mutations in the pol and rex genes. Virology Journal, 10, 1-9. [More Information]
  • Saksena, N., Conceicao, V., Perera, S., Wu, J. (2013). Gene array data relevant to immunological and virological monitoring of human immunodeficiency virus type 1 infection. Current Opinion in HIV and AIDS, 8(2), 132-139. [More Information]
  • Ho, Y., Saksena, N. (2013). Glycosylation in HIV-1 envelope glycoprotein and its biological implications. Future Virology, 8(8), 783-800. [More Information]
  • Zhou, L., Saksena, N. (2013). HIV Associated Neurocognitive Disorders. Infectious Disease Reports, 5(Suppl. 1), 38-50. [More Information]
  • Fowler, L., Saksena, N. (2013). Micro-RNA: new players in HIV-pathogenesis, diagnosis, prognosis and antiviral therapy. AIDS Reviews, 15(1), 3-14. [More Information]
  • Gupta, P., Saksena, N. (2013). miRNAs: small molecules with a big impact on HIV infection and pathogenesis. Future Virology, 8(8), 769-781. [More Information]
  • Saksena, N., Dwyer, D., Zhao, R. (2013). Special Issue on HIV/AIDS: Infectious Disease Reports. Infectious Disease Reports, 5(Suppl1), e1-e1. [More Information]
  • Wu, J., Sasse, T., Miranda Saksena, M., Saksena, N. (2013). Transcriptome analysis of primary monocytes from HIV-positive patients with differential responses to antiretroviral therapy. Virology Journal, 10, 1-16. [More Information]
  • Wu, J., Sasse, T., Wolkenstein, G., Conceicao, V., Miranda Saksena, M., Soedjono, M., Perera, S., Wang, B., Dwyer, D., Saksena, N. (2013). Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors. Virology, 435(2), 308-319. [More Information]
  • Zhou, L., Miranda-Saksena, M., Saksena, N. (2013). Viruses and neurodegeneration. Virology Journal, 10, 1-17. [More Information]
  • Zhou, L., Pupo, G., Gupta, P., Liu, B., Tran, S., Rahme, R., Wang, B., Rua, R., Rizos, H., Carroll, A., Saksena, N., et al (2012). A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration. BMC Genomics, 13(November), 1-17. [More Information]
  • Wang, B., Taylor, J., Ratnamohan, M., McPhie, K., Kesson, A., Dixit, R., Booy, R., Hurt, A., Saksena, N., Dwyer, D. (2012). Frequency of oseltamivir resistance in Sydney, during the Newcastle outbreak of community transmitted oseltamivir-resistant influenza A(H1N1)pdm09 virus, Australia, June to August 2011. Eurosurveillance (Online Edition), 17(27), 1-6. [More Information]
  • Czubala, M., Matlho, K., Arriaga, M., Dyer, W., Wang, B., Chew, C., Dwyer, D., Saksena, N. (2012). High frequency of stop codons in the human immunodeficiency virus-1 protease gene frame in human immunodeficiency virus individuals with below detectable levels of plasma viremia during highly active antiretroviral therapy. American Journal of Infectious Diseases, 8(3), 115-122. [More Information]
  • Perera, S., Saksena, N. (2012). Innate, adaptive and intrinsic immunity in human immunodeficiency virus infection. American Journal of Infectious Diseases, 8(3), 132-148. [More Information]
  • Sasse, T., Wu, J., Zhou, L., Saksena, N. (2012). Monocytes and their Role in Human Immunodeficiency Virus Pathogenesis. American Journal of Infectious Diseases, 8(2), 92-105.
  • Zhou, L., Conceicao, V., Gupta, P., Saksena, N. (2012). Why are the neurodegenerative disease-related pathways overrepresented in primary HIV-infected peripheral blood mononuclear cells: a genome-wide perspective. Virology Journal, 9, 1-7. [More Information]
  • Wang, B., Dwyer, D., Soedjono, M., Shi, H., Matlho, K., Ratnamohan, M., Blyth, C., McPhie, K., Cunningham, A., Saksena, N. (2011). Evidence of the circulation of pandemic influenza (H1N1) 2009 with D222D/G/N/S hemagglutinin polymorphisms during the first wave of the 2009 influenza pandemic. Journal Of Clinical Virology, 52(4), 304-306. [More Information]
  • Wu, J., Dwyer, D., Dyer, W., Yang, J., Wang, B., Saksena, N. (2011). Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease. Retrovirology, 8(18), 1-21. [More Information]
  • Wang, B., Steain, M., Dwyer, D., Cunningham, A., Saksena, N. (2011). Synthetic long oligonucleotides to generate artificial templates for use as positive controls in molecular assays: drug resistance mutations in influenza virus as an example. Virology Journal, 8(August), 405-(7pp). [More Information]
  • Wightman, F., Solomon, A., Khoury, G., Green, J., Gray, L., Gorry, P., Ho, Y., Saksena, N., Hoy, J., Crowe, S., et al (2010). Both CD31(+) and CD31(-) Naive CD4(+) T Cells Are Persistent HIV Type 1-Infected Reservoirs in Individuals Receiving Antiretroviral Therapy. The Journal of Infectious Diseases, 202(11), 1738-1748. [More Information]
  • Wang, B., Dwyer, D., Blyth, C., Soedjono, M., Shi, H., Kesson, A., Ratnamohan, M., McPhie, K., Cunningham, A., Saksena, N. (2010). Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections. Antiviral Research, 87(1), 16-21. [More Information]
  • Wade, J., Sterjovski, J., Gray, L., Roche, M., Chiavaroli, L., Ellett, A., Jakobsen, M., Cowley, D., da Fonseca Pereira, C., Saksena, N., Wang, B., et al (2010). Enhanced CD4+cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection. Virology, 396(2), 246-255. [More Information]
  • Lau, K., Wang, B., Miranda Saksena, M., Boadle, R., Kamarulzaman, A., Ng, K., Saksena, N. (2010). Evidence for Possible Biological Advantages of the Newly Emerging HIV-1 Circulating Recombinant Form from Malaysia - CRF33_01B in Comparison to its Progenitors _ CRF01_AE and Subtype B. Current HIV Research, 8(3), 259-271. [More Information]
  • Zhou, L., Diefenbach, E., Crossett, B., Tran, S., Ng, T., Rizos, H., Rua, R., Wang, B., Kapur, A., Gandhi, K., Saksena, N., et al (2010). First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia. Molecular Neurodegeneration, 5(27), 27-1-27-20. [More Information]
  • Yoo, P., Ho, Y., Ng, J., Charleston, M., Saksena, N., Yang, P., Zomaya, A. (2010). Hierarchical kernel mixture models for the prediction of AIDS disease progression using HIV structural gp120 profiles. BMC Genomics, 11 Suppl 4(S22), 1-10. [More Information]
  • Saksena, N., Wang, B., Zhou, L., Soedjono, M., Ho, Y., Conceicao, V. (2010). HIV Reservoirs in vivo and New Strategies for Possible Eradication of HIV from the Reservoir Sites. HIV/AIDS, 2, 103-122. [More Information]
  • Steain, M., Dwyer, D., Hurt, A., Kol, C., Saksena, N., Cunningham, A., Wang, B. (2009). Detection of influenza A H1N1 and H3N2 mutations conferring resistance to oseltamivir using rolling circle amplification. Antiviral Research, 84(3), 242-248. [More Information]
  • Zhou, L., Rua, R., Ng, T., Vongrad, V., Ho, Y., Geczy, C., Hsu, K., Brew, B., Saksena, N. (2009). Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia. BMC Infectious Diseases, 9, 192-1-192-14. [More Information]
  • Rosewell, A., Wang, B., Saksena, N., MacIntyre, C., Lindley, R., Chiu, C., Shineberg, C., Clarke, E., McPhie, K., Ratnamohan, M., Booy, R., Dwyer, D. (2009). Failure to Detect Oseltamivir Resistance by Rolling Circle Amplification and Sequencing Following Use in an Influenza A (H3N2) Outbreak at an Aged Care Facility. Journal of Antivirals and Antiretrovirals, 1(1), 56-61.
  • van Hal, S., Deris, Z., Wang, B., Saksena, N., Dwyer, D. (2009). HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure. Retrovirology, 6, 12. [More Information]
  • Wang, B., Dwyer, D., Chew, C., Kol, C., Ping He, Z., Joshi, H., Steain, M., Cunningham, A., Saksena, N. (2009). Sensitive detection of the K103N non-nucleoside reverse transcriptase inhibitor resistance mutation in treatment-naïve HIV-1 infected individuals by rolling circle amplification. Journal of Virological Methods, 161(1), 128-135. [More Information]
  • Gray, L., Roche, M., Churchill, M., Sterjovski, J., Ellett, A., Poumbourios, P., Sheffief, S., Wang, B., Saksena, N., Purcell, D., Cunningham, A., et al (2009). Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain. Journal of Virology, 83(11), 5430-5441.
  • Ho, Y., Abecasis, A., Theys, K., Deforche, K., Dwyer, D., Charleston, M., Vandamme, A., Saksena, N. (2008). HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments. Virology Journal, 5(14), 1-10. [More Information]
  • Saksena, N., Wu, J., Potter, S., Wilkinson, J., Wang, B. (2008). Human immunodeficiency virus interactions with CD8+ T lymphocytes. Current HIV Research, 6(1), 1-9. [More Information]
  • Caly, L., Saksena, N., Piller, S., Jans, D. (2008). Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor. Retrovirology, 5(67), 1-7. [More Information]
  • Wu, J., Dyer, W., Chrisp, J., Belov, L., Wang, B., Saksena, N. (2008). Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy. Retrovirology, 5(24), 1-12. [More Information]
  • Dyer, W., Zaunders, J., Yuan, F., Wang, B., Learmont, J., Geczy, A., Saksena, N., McPhee, D., Gorry, P., Sullivan, J. (2008). Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection. Retrovirology, 5, 112-1-112-14. [More Information]
  • Zhou, L., Ng, T., Yuksel, A., Wang, B., Dwyer, D., Saksena, N. (2008). Short communication: Absence of HIV infection in the choroid plexus of two patients who died rapidly with HIV-associated dementia. AIDS Research and Human Retroviruses, 24(6), 839-843. [More Information]
  • Steain, M., Wang, B., Saksena, N. (2008). The possible contribution of HIV-1-induced syncytia to the generation of intersubtype recombinants in vitro. AIDS, 22(9), 1009-1017. [More Information]
  • Wu, J., Dwyer, D., Dyer, W., Yang, J., Wang, B., Saksena, N. (2008). Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses. Virology, 380(1), 124-135. [More Information]
  • Wu, J., Wang, B., Saksena, N. (2008). Transitory viremic surges in a human immunodeficiency virus-positive elite controller can shift the cellular transcriptome profile: a word of caution for microarray studies. Journal of Virology, 82(20), 10326-10327. [More Information]
  • Wu, J., Wang, B., Belov, L., Chrisp, J., Learmont, J., Dyer, W., Zaunders, J., Cunningham, A., Dwyer, D., Saksena, N. (2007). Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages. Retrovirology, 4(83), 1-13. [More Information]
  • Sterjovski, J., Churchill, M., Ellett, A., Gray, L., Roche, M., Dunfee, R., Purcell, D., Saksena, N., Wang, B., Sonza, S., Cunningham, A., Gorry, P., et al (2007). Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS. Retrovirology, 4(Article number 89), 89-page 1 - 21. [More Information]
  • Wang, B., Lau, K., Ong, L., Shah, M., Steain, M., Foley, B., Dwyer, D., Kamarulzaman, A., Ng, K., Saksena, N. (2007). Complex patterns of the HIV-1 epidemic in Kuala Lumpur, Malaysia: Evidence for expansion of circulating recombinant form CRF33_01B and detection of multiple other recombinants. Virology, 367(2), 288-297. [More Information]
  • Wang, Y., Dyer, W., Workman, C., Wang, B., Peng, N., Lachireddy, K., Chew, C., Sullivan, J., Saksena, N. (2007). Drug resistance and viral evolution in plasma and peripheral blood cells during structured treatment interruption (STI) and non-interrupted HAART. Current HIV Research, 5(2), 235-250. [More Information]
  • Saksena, N., Rodes, B., Wang, B., Soriano, V. (2007). Elite HIV controllers: myth or reality? AIDS Reviews, 9(4), 195-207. [More Information]
  • Lau, K., Wang, B., Saksena, N. (2007). Emerging trends of HIV epidemiology in Asia. AIDS Reviews, 9(4), 218-229. [More Information]
  • Wang, Y., Wang, B., Dyer, W., Lachireddy, K., Peng, N., Saksena, N. (2007). Evidence for predominance of CCR5-using HIV-1 strains during highly active antiretroviral therapy. Current HIV Research, 5(2), 221-234. [More Information]
  • Sivakumaran, H., Wang, B., Gill, M., Beckholdt, B., Saksena, N., Harrich, D. (2007). Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort. Virology Journal, 4(Article number 107), 107-page 1 -5. [More Information]
  • Lau, K., Wang, B., Kamarulzaman, A., Peng, N., Saksena, N. (2007). Near Full-Length Sequence Analysis of a Unique CRF01_AE/B Recombinant from Kuala Lumpur, Malaysia. AIDS Research and Human Retroviruses, 23(9), 1139-1145. [More Information]
  • Steain, M., Wang, B., Saksena, N. (2006). Analysis of HIV-1 sequences vertically transmitted to infants in Kisumu, Kenya. Journal Of Clinical Virology, 36(4), 298-302. [More Information]
  • Verity, E., williams, L., Haddad, D., Choy, V., O'Loughlin, C., Chatfield, C., Saksena, N., Cunningham, A., Gelder, F., McPhee, D. (2006). Broad neutralization and complement-mediated lysis of HIV-1 by (PE)HRG214, a novel caprine anti-HIV-1 polyclonal antibody. AIDS, 20(4), 505-515.
  • Shah, M., Smit, T., Morgello, S., Tourtellotte, W., Gelman, B., Brew, B., Saksena, N. (2006). Env gp120 sequence analysis of HIV type 1 strains from diverse areas of the brain shows preponderance of CCR5 usage. AIDS Research and Human Retroviruses, 22(2), 177-181. [More Information]
  • Potter, S., Lemey, P., Dyer, W., Sullivan, J., Chew, C., Vandamme, A., Dwyer, D., Saksena, N. (2006). Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAART. Virology, 348(1), 35-46. [More Information]
  • Gray, L., Churchill, M., Keane, N., Sterjovski, J., Ellett, A., Purcell, D., Poumbourios, P., Kol, C., Wang, B., Saksena, N., et al (2006). Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5 Delta 32 allele. Journal of Virology, 80(7), 3684-3691.
  • Arriaga, M., Carr, J., Li, P., Wang, B., Saksena, N. (2006). Interaction between HIV-1 and APOBEC3 sub-family of proteins. Current HIV Research, 4(4), 401-409. [More Information]
  • Chew, C., Potter, S., Wang, B., Wang, Y., Shaw, C., Dwyer, D., Saksena, N. (2005). Assessment of drug resistance mutations in plasma and peripheral blood mononuclear cells at different plasma viral loads in patients receiving HAART. Journal Of Clinical Virology, 33(3), 206-216. [More Information]
  • Cali, L., Wang, B., Mikhail, M., Gill, M., Beckthold, B., Salemi, M., Jans, D., Piller, S., Saksena, N. (2005). Evidence for host-driven selection of the HIV type 1 vpr gene in vivo during HIV disease progression in a transfusion-acquired cohort. AIDS Research and Human Retroviruses, 21(8), 728-733. [More Information]
  • Mikhail, M., Wang, B., Lemey, P., Beckthold, B., Vandamme, A., Gill, M., Saksena, N. (2005). Full-length HIV type 1 genome analysis showing evidence for HIV type 1 transmission from a nonprogressor to two recipients who progressed to AIDS. AIDS Research and Human Retroviruses, 21(6), 575-579. [More Information]
  • Saksena, N., Smit, T. (2005). HAART & the molecular biology of AIDS dementia complex. Indian Journal of Medical Research, 121(4), 256-269. [More Information]
  • Steain, M., Wang, B., Yang, C., Shi, Y., Nahlen, B., Lal, R., Saksena, N. (2005). HIV type 1 sequence diversity and dual infections in Kenya. AIDS Research and Human Retroviruses, 21(10), 882-5. [More Information]
  • Wang, B., Potter, S., Lin, Y., Cunningham, A., Dwyer, D., Su, Y., Ma, X., Hou, Y., Saksena, N. (2005). Rapid and sensitive detection of severe acute respiratory syndrome coronavirus by rolling circle amplification. Journal of Clinical Microbiology, 43(5), 2339-2244. [More Information]
  • Mikhail, M., Wang, B., Lemey, P., Beckthold, B., Vandamme, A., Gill, M., Saksena, N. (2005). Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort. Retrovirology, 2(1), 41 - 1-41 - 10. [More Information]
  • Saksena, N., Wang, B., Steain, M., Yang, R., Zhang, L. (2005). Snapshot of HIV pathogenesis in China. Cell Research, 15(11-12), 953-961. [More Information]
  • Steain, M., Wang, B., Dwyer, D., Saksena, N. (2004). HIV-1 co-infection, superinfection and recombination. Sexual Health, 1(4), 239-250.
  • Potter, S., Lemey, P., Achaz, G., Chew, C., Vandamme, A., Dwyer, D., Saksena, N. (2004). Hiv-1 Compartmentalization In Diverse Leukocyte Populations During Antiretroviral Therapy. Journal of Leukocyte Biology, 76(3), 562-570.
  • Otake, K., Omoto, S., Yamamoto, T., Okuyama, H., Okada, H., Okada, N., Kawai, M., Saksena, N., Fujii, Y. (2004). Hiv-1 Nef Protein In The Nucleus Influences Adipogenesis As Well As Viral Transcription Through The Peroxisome Proliferator-Activated Receptors. AIDS, 18(2), 189-198.
  • Omoto, S., Ito, M., Tsutsumi, Y., Ichikawa, Y., Okuyama, H., Brisibe, E., Saksena, N., Fujii, Y. (2004). Hiv-1 Nef Suppression By Virally Encoded Microrna. Retrovirology, 1, 44-55.
  • Zaunders, J., Dyer, W., Wang, B., Munier, M., Miranda Saksena, M., Newton, R., Moore, J., Mackay, C., Cooper, D., Saksena, N., et al (2004). Identification Of Circulating Antigen-Specific Cd4+ T Lymphocytes With A Ccr5+, Cytotoxic Phenotype In An Hiv-1 Long-Term Nonprogressor And In Cmv Infection. Blood, 103(6), 2238-2247.
  • Smit, T., Brew, B., Tourtellotte, W., Morgello, S., Gelman, B., Saksena, N. (2004). Independent Evolution Of Human Immunodeficiency Virus (Hiv) Drug Resistance Mutations In Diverse Areas Of The Brain In Hiv-Infected Patients, With And Without Dementia, On Antiretroviral Treatment. Journal of Virology, 78(18), 10133-10148.
  • Potter, S., Chew, C., Steain, M., Dwyer, D., Saksena, N. (2004). Obstacles To Successful Antiretroviral Treatment Of Hiv-1 Infection: Problems & Perspectives. Indian Journal of Medical Research, 119, 217-37.
  • Potter, S., Dwyer, D., Saksena, N. (2003). Differential cellular distribution of HIV-1 drug resistance in vivo: evidence for infection of CD8+ T cells during HAART. Virology, 305(2), 339-352. [More Information]
  • Wang, B., Mikhail, M., Dyer, W., Zaunders, J., Kelleher, A., Saksena, N. (2003). First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetence HIV-1 infection. Virology, 312(1), 135-150.
  • Mikhail, M., Wang, B., Saksena, N. (2003). Mechanisms involved in non-progressive HIV disease. AIDS Reviews, (4), 230-244.
  • Herring, B., Ge, Y., Wang, B., Ratnamohan, M., Zheng, F., Cunningham, A., Saksena, N., Dwyer, D. (2003). Segregation of human immunodificiency virus type 1 subtypes by risk factor in Australia. Journal of Clinical Microbiology, 41(10), 4600-4604.
  • Lemey, P., Salemi, M., Wang, B., Duffy, M., Hall, W., Saksena, N., Vandamme, A. (2003). Site stripping based on likelihood ratio reduction is a useful tool fo evaluate the impact of non-clock-like behavior on viral phylogenetic reconstructions. FEMS Immunology and Medical Microbiology, 39(2), 125-132.
  • Lemey, P., Pybus, O., Wang, B., Saksena, N., Salemi, M., Vandamme, A. (2003). Tracing the origin and history of the HIV-2 epidemic. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 100(11), 6588-6592.
  • Saksena, N., Cunningham, A., Birch,, M., Learmont, J., Dyer,, W., Deacon,, N., Zaunders, J., Mills,, J., Sullivan, J. (2001). An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC). Journal of Virology, 22, 263-270.

2014

  • Gupta, P., Liu, B., Wu, J., Soriano, V., Vispo, E., Carroll, A., Goldie, B., Cairns, M., Saksena, N. (2014). Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection. Virology, 450-451, 336-349. [More Information]
  • Gupta, P., Cairns, M., Saksena, N. (2014). Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma. Virology Journal, 11(1), 64- 1-64-14. [More Information]

2013

  • Dube, S., Saksena, N., Spicer, T., Healey, J., Benz, P., Dube, D., Poiesz, B. (2013). Delayed seroconversion to STLV-1 infection is associated with mutations in the pol and rex genes. Virology Journal, 10, 1-9. [More Information]
  • Saksena, N., Conceicao, V., Perera, S., Wu, J. (2013). Gene array data relevant to immunological and virological monitoring of human immunodeficiency virus type 1 infection. Current Opinion in HIV and AIDS, 8(2), 132-139. [More Information]
  • Ho, Y., Saksena, N. (2013). Glycosylation in HIV-1 envelope glycoprotein and its biological implications. Future Virology, 8(8), 783-800. [More Information]
  • Zhou, L., Saksena, N. (2013). HIV Associated Neurocognitive Disorders. Infectious Disease Reports, 5(Suppl. 1), 38-50. [More Information]
  • Fowler, L., Saksena, N. (2013). Micro-RNA: new players in HIV-pathogenesis, diagnosis, prognosis and antiviral therapy. AIDS Reviews, 15(1), 3-14. [More Information]
  • Gupta, P., Saksena, N. (2013). miRNAs: small molecules with a big impact on HIV infection and pathogenesis. Future Virology, 8(8), 769-781. [More Information]
  • Saksena, N., Dwyer, D., Zhao, R. (2013). Special Issue on HIV/AIDS: Infectious Disease Reports. Infectious Disease Reports, 5(Suppl1), e1-e1. [More Information]
  • Wu, J., Sasse, T., Miranda Saksena, M., Saksena, N. (2013). Transcriptome analysis of primary monocytes from HIV-positive patients with differential responses to antiretroviral therapy. Virology Journal, 10, 1-16. [More Information]
  • Wu, J., Sasse, T., Wolkenstein, G., Conceicao, V., Miranda Saksena, M., Soedjono, M., Perera, S., Wang, B., Dwyer, D., Saksena, N. (2013). Transcriptome analysis of primary monocytes shows global down-regulation of genetic networks in HIV viremic patients versus long-term non-progressors. Virology, 435(2), 308-319. [More Information]
  • Zhou, L., Miranda-Saksena, M., Saksena, N. (2013). Viruses and neurodegeneration. Virology Journal, 10, 1-17. [More Information]

2012

  • Zhou, L., Pupo, G., Gupta, P., Liu, B., Tran, S., Rahme, R., Wang, B., Rua, R., Rizos, H., Carroll, A., Saksena, N., et al (2012). A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration. BMC Genomics, 13(November), 1-17. [More Information]
  • Wang, B., Taylor, J., Ratnamohan, M., McPhie, K., Kesson, A., Dixit, R., Booy, R., Hurt, A., Saksena, N., Dwyer, D. (2012). Frequency of oseltamivir resistance in Sydney, during the Newcastle outbreak of community transmitted oseltamivir-resistant influenza A(H1N1)pdm09 virus, Australia, June to August 2011. Eurosurveillance (Online Edition), 17(27), 1-6. [More Information]
  • Czubala, M., Matlho, K., Arriaga, M., Dyer, W., Wang, B., Chew, C., Dwyer, D., Saksena, N. (2012). High frequency of stop codons in the human immunodeficiency virus-1 protease gene frame in human immunodeficiency virus individuals with below detectable levels of plasma viremia during highly active antiretroviral therapy. American Journal of Infectious Diseases, 8(3), 115-122. [More Information]
  • Perera, S., Saksena, N. (2012). Innate, adaptive and intrinsic immunity in human immunodeficiency virus infection. American Journal of Infectious Diseases, 8(3), 132-148. [More Information]
  • Sasse, T., Wu, J., Zhou, L., Saksena, N. (2012). Monocytes and their Role in Human Immunodeficiency Virus Pathogenesis. American Journal of Infectious Diseases, 8(2), 92-105.
  • Zhou, L., Conceicao, V., Gupta, P., Saksena, N. (2012). Why are the neurodegenerative disease-related pathways overrepresented in primary HIV-infected peripheral blood mononuclear cells: a genome-wide perspective. Virology Journal, 9, 1-7. [More Information]

2011

  • Wang, B., Dwyer, D., Soedjono, M., Shi, H., Matlho, K., Ratnamohan, M., Blyth, C., McPhie, K., Cunningham, A., Saksena, N. (2011). Evidence of the circulation of pandemic influenza (H1N1) 2009 with D222D/G/N/S hemagglutinin polymorphisms during the first wave of the 2009 influenza pandemic. Journal Of Clinical Virology, 52(4), 304-306. [More Information]
  • Wu, J., Dwyer, D., Dyer, W., Yang, J., Wang, B., Saksena, N. (2011). Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease. Retrovirology, 8(18), 1-21. [More Information]
  • Wang, B., Steain, M., Dwyer, D., Cunningham, A., Saksena, N. (2011). Synthetic long oligonucleotides to generate artificial templates for use as positive controls in molecular assays: drug resistance mutations in influenza virus as an example. Virology Journal, 8(August), 405-(7pp). [More Information]

2010

  • Wightman, F., Solomon, A., Khoury, G., Green, J., Gray, L., Gorry, P., Ho, Y., Saksena, N., Hoy, J., Crowe, S., et al (2010). Both CD31(+) and CD31(-) Naive CD4(+) T Cells Are Persistent HIV Type 1-Infected Reservoirs in Individuals Receiving Antiretroviral Therapy. The Journal of Infectious Diseases, 202(11), 1738-1748. [More Information]
  • Wang, B., Dwyer, D., Blyth, C., Soedjono, M., Shi, H., Kesson, A., Ratnamohan, M., McPhie, K., Cunningham, A., Saksena, N. (2010). Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections. Antiviral Research, 87(1), 16-21. [More Information]
  • Wade, J., Sterjovski, J., Gray, L., Roche, M., Chiavaroli, L., Ellett, A., Jakobsen, M., Cowley, D., da Fonseca Pereira, C., Saksena, N., Wang, B., et al (2010). Enhanced CD4+cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection. Virology, 396(2), 246-255. [More Information]
  • Lau, K., Wang, B., Miranda Saksena, M., Boadle, R., Kamarulzaman, A., Ng, K., Saksena, N. (2010). Evidence for Possible Biological Advantages of the Newly Emerging HIV-1 Circulating Recombinant Form from Malaysia - CRF33_01B in Comparison to its Progenitors _ CRF01_AE and Subtype B. Current HIV Research, 8(3), 259-271. [More Information]
  • Zhou, L., Diefenbach, E., Crossett, B., Tran, S., Ng, T., Rizos, H., Rua, R., Wang, B., Kapur, A., Gandhi, K., Saksena, N., et al (2010). First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia. Molecular Neurodegeneration, 5(27), 27-1-27-20. [More Information]
  • Yoo, P., Ho, Y., Ng, J., Charleston, M., Saksena, N., Yang, P., Zomaya, A. (2010). Hierarchical kernel mixture models for the prediction of AIDS disease progression using HIV structural gp120 profiles. BMC Genomics, 11 Suppl 4(S22), 1-10. [More Information]
  • Saksena, N., Wang, B., Zhou, L., Soedjono, M., Ho, Y., Conceicao, V. (2010). HIV Reservoirs in vivo and New Strategies for Possible Eradication of HIV from the Reservoir Sites. HIV/AIDS, 2, 103-122. [More Information]

2009

  • Steain, M., Dwyer, D., Hurt, A., Kol, C., Saksena, N., Cunningham, A., Wang, B. (2009). Detection of influenza A H1N1 and H3N2 mutations conferring resistance to oseltamivir using rolling circle amplification. Antiviral Research, 84(3), 242-248. [More Information]
  • Zhou, L., Rua, R., Ng, T., Vongrad, V., Ho, Y., Geczy, C., Hsu, K., Brew, B., Saksena, N. (2009). Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia. BMC Infectious Diseases, 9, 192-1-192-14. [More Information]
  • Rosewell, A., Wang, B., Saksena, N., MacIntyre, C., Lindley, R., Chiu, C., Shineberg, C., Clarke, E., McPhie, K., Ratnamohan, M., Booy, R., Dwyer, D. (2009). Failure to Detect Oseltamivir Resistance by Rolling Circle Amplification and Sequencing Following Use in an Influenza A (H3N2) Outbreak at an Aged Care Facility. Journal of Antivirals and Antiretrovirals, 1(1), 56-61.
  • van Hal, S., Deris, Z., Wang, B., Saksena, N., Dwyer, D. (2009). HIV-1 integrase polymorphisms are associated with prior antiretroviral drug exposure. Retrovirology, 6, 12. [More Information]
  • Wang, B., Dwyer, D., Chew, C., Kol, C., Ping He, Z., Joshi, H., Steain, M., Cunningham, A., Saksena, N. (2009). Sensitive detection of the K103N non-nucleoside reverse transcriptase inhibitor resistance mutation in treatment-naïve HIV-1 infected individuals by rolling circle amplification. Journal of Virological Methods, 161(1), 128-135. [More Information]
  • Gray, L., Roche, M., Churchill, M., Sterjovski, J., Ellett, A., Poumbourios, P., Sheffief, S., Wang, B., Saksena, N., Purcell, D., Cunningham, A., et al (2009). Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain. Journal of Virology, 83(11), 5430-5441.

2008

  • Ho, Y., Abecasis, A., Theys, K., Deforche, K., Dwyer, D., Charleston, M., Vandamme, A., Saksena, N. (2008). HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments. Virology Journal, 5(14), 1-10. [More Information]
  • Saksena, N., Wu, J., Potter, S., Wilkinson, J., Wang, B. (2008). Human immunodeficiency virus interactions with CD8+ T lymphocytes. Current HIV Research, 6(1), 1-9. [More Information]
  • Caly, L., Saksena, N., Piller, S., Jans, D. (2008). Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor. Retrovirology, 5(67), 1-7. [More Information]
  • Wu, J., Dyer, W., Chrisp, J., Belov, L., Wang, B., Saksena, N. (2008). Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy. Retrovirology, 5(24), 1-12. [More Information]
  • Dyer, W., Zaunders, J., Yuan, F., Wang, B., Learmont, J., Geczy, A., Saksena, N., McPhee, D., Gorry, P., Sullivan, J. (2008). Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection. Retrovirology, 5, 112-1-112-14. [More Information]
  • Zhou, L., Ng, T., Yuksel, A., Wang, B., Dwyer, D., Saksena, N. (2008). Short communication: Absence of HIV infection in the choroid plexus of two patients who died rapidly with HIV-associated dementia. AIDS Research and Human Retroviruses, 24(6), 839-843. [More Information]
  • Steain, M., Wang, B., Saksena, N. (2008). The possible contribution of HIV-1-induced syncytia to the generation of intersubtype recombinants in vitro. AIDS, 22(9), 1009-1017. [More Information]
  • Wu, J., Dwyer, D., Dyer, W., Yang, J., Wang, B., Saksena, N. (2008). Transcriptional profiles in CD8+ T cells from HIV+ progressors on HAART are characterized by coordinated up-regulation of oxidative phosphorylation enzymes and interferon responses. Virology, 380(1), 124-135. [More Information]
  • Wu, J., Wang, B., Saksena, N. (2008). Transitory viremic surges in a human immunodeficiency virus-positive elite controller can shift the cellular transcriptome profile: a word of caution for microarray studies. Journal of Virology, 82(20), 10326-10327. [More Information]

2007

  • Wu, J., Wang, B., Belov, L., Chrisp, J., Learmont, J., Dyer, W., Zaunders, J., Cunningham, A., Dwyer, D., Saksena, N. (2007). Antibody microarray analysis of cell surface antigens on CD4+ and CD8+ T cells from HIV+ individuals correlates with disease stages. Retrovirology, 4(83), 1-13. [More Information]
  • Sterjovski, J., Churchill, M., Ellett, A., Gray, L., Roche, M., Dunfee, R., Purcell, D., Saksena, N., Wang, B., Sonza, S., Cunningham, A., Gorry, P., et al (2007). Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS. Retrovirology, 4(Article number 89), 89-page 1 - 21. [More Information]
  • Wang, B., Lau, K., Ong, L., Shah, M., Steain, M., Foley, B., Dwyer, D., Kamarulzaman, A., Ng, K., Saksena, N. (2007). Complex patterns of the HIV-1 epidemic in Kuala Lumpur, Malaysia: Evidence for expansion of circulating recombinant form CRF33_01B and detection of multiple other recombinants. Virology, 367(2), 288-297. [More Information]
  • Wang, Y., Dyer, W., Workman, C., Wang, B., Peng, N., Lachireddy, K., Chew, C., Sullivan, J., Saksena, N. (2007). Drug resistance and viral evolution in plasma and peripheral blood cells during structured treatment interruption (STI) and non-interrupted HAART. Current HIV Research, 5(2), 235-250. [More Information]
  • Saksena, N., Rodes, B., Wang, B., Soriano, V. (2007). Elite HIV controllers: myth or reality? AIDS Reviews, 9(4), 195-207. [More Information]
  • Lau, K., Wang, B., Saksena, N. (2007). Emerging trends of HIV epidemiology in Asia. AIDS Reviews, 9(4), 218-229. [More Information]
  • Wang, Y., Wang, B., Dyer, W., Lachireddy, K., Peng, N., Saksena, N. (2007). Evidence for predominance of CCR5-using HIV-1 strains during highly active antiretroviral therapy. Current HIV Research, 5(2), 221-234. [More Information]
  • Sivakumaran, H., Wang, B., Gill, M., Beckholdt, B., Saksena, N., Harrich, D. (2007). Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort. Virology Journal, 4(Article number 107), 107-page 1 -5. [More Information]
  • Lau, K., Wang, B., Kamarulzaman, A., Peng, N., Saksena, N. (2007). Near Full-Length Sequence Analysis of a Unique CRF01_AE/B Recombinant from Kuala Lumpur, Malaysia. AIDS Research and Human Retroviruses, 23(9), 1139-1145. [More Information]

2006

  • Steain, M., Wang, B., Saksena, N. (2006). Analysis of HIV-1 sequences vertically transmitted to infants in Kisumu, Kenya. Journal Of Clinical Virology, 36(4), 298-302. [More Information]
  • Verity, E., williams, L., Haddad, D., Choy, V., O'Loughlin, C., Chatfield, C., Saksena, N., Cunningham, A., Gelder, F., McPhee, D. (2006). Broad neutralization and complement-mediated lysis of HIV-1 by (PE)HRG214, a novel caprine anti-HIV-1 polyclonal antibody. AIDS, 20(4), 505-515.
  • Shah, M., Smit, T., Morgello, S., Tourtellotte, W., Gelman, B., Brew, B., Saksena, N. (2006). Env gp120 sequence analysis of HIV type 1 strains from diverse areas of the brain shows preponderance of CCR5 usage. AIDS Research and Human Retroviruses, 22(2), 177-181. [More Information]
  • Potter, S., Lemey, P., Dyer, W., Sullivan, J., Chew, C., Vandamme, A., Dwyer, D., Saksena, N. (2006). Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAART. Virology, 348(1), 35-46. [More Information]
  • Gray, L., Churchill, M., Keane, N., Sterjovski, J., Ellett, A., Purcell, D., Poumbourios, P., Kol, C., Wang, B., Saksena, N., et al (2006). Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5 Delta 32 allele. Journal of Virology, 80(7), 3684-3691.
  • Arriaga, M., Carr, J., Li, P., Wang, B., Saksena, N. (2006). Interaction between HIV-1 and APOBEC3 sub-family of proteins. Current HIV Research, 4(4), 401-409. [More Information]

2005

  • Chew, C., Potter, S., Wang, B., Wang, Y., Shaw, C., Dwyer, D., Saksena, N. (2005). Assessment of drug resistance mutations in plasma and peripheral blood mononuclear cells at different plasma viral loads in patients receiving HAART. Journal Of Clinical Virology, 33(3), 206-216. [More Information]
  • Cali, L., Wang, B., Mikhail, M., Gill, M., Beckthold, B., Salemi, M., Jans, D., Piller, S., Saksena, N. (2005). Evidence for host-driven selection of the HIV type 1 vpr gene in vivo during HIV disease progression in a transfusion-acquired cohort. AIDS Research and Human Retroviruses, 21(8), 728-733. [More Information]
  • Mikhail, M., Wang, B., Lemey, P., Beckthold, B., Vandamme, A., Gill, M., Saksena, N. (2005). Full-length HIV type 1 genome analysis showing evidence for HIV type 1 transmission from a nonprogressor to two recipients who progressed to AIDS. AIDS Research and Human Retroviruses, 21(6), 575-579. [More Information]
  • Saksena, N., Smit, T. (2005). HAART & the molecular biology of AIDS dementia complex. Indian Journal of Medical Research, 121(4), 256-269. [More Information]
  • Steain, M., Wang, B., Yang, C., Shi, Y., Nahlen, B., Lal, R., Saksena, N. (2005). HIV type 1 sequence diversity and dual infections in Kenya. AIDS Research and Human Retroviruses, 21(10), 882-5. [More Information]
  • Wang, B., Potter, S., Lin, Y., Cunningham, A., Dwyer, D., Su, Y., Ma, X., Hou, Y., Saksena, N. (2005). Rapid and sensitive detection of severe acute respiratory syndrome coronavirus by rolling circle amplification. Journal of Clinical Microbiology, 43(5), 2339-2244. [More Information]
  • Mikhail, M., Wang, B., Lemey, P., Beckthold, B., Vandamme, A., Gill, M., Saksena, N. (2005). Role of viral evolutionary rate in HIV-1 disease progression in a linked cohort. Retrovirology, 2(1), 41 - 1-41 - 10. [More Information]
  • Saksena, N., Wang, B., Steain, M., Yang, R., Zhang, L. (2005). Snapshot of HIV pathogenesis in China. Cell Research, 15(11-12), 953-961. [More Information]

2004

  • Steain, M., Wang, B., Dwyer, D., Saksena, N. (2004). HIV-1 co-infection, superinfection and recombination. Sexual Health, 1(4), 239-250.
  • Potter, S., Lemey, P., Achaz, G., Chew, C., Vandamme, A., Dwyer, D., Saksena, N. (2004). Hiv-1 Compartmentalization In Diverse Leukocyte Populations During Antiretroviral Therapy. Journal of Leukocyte Biology, 76(3), 562-570.
  • Otake, K., Omoto, S., Yamamoto, T., Okuyama, H., Okada, H., Okada, N., Kawai, M., Saksena, N., Fujii, Y. (2004). Hiv-1 Nef Protein In The Nucleus Influences Adipogenesis As Well As Viral Transcription Through The Peroxisome Proliferator-Activated Receptors. AIDS, 18(2), 189-198.
  • Omoto, S., Ito, M., Tsutsumi, Y., Ichikawa, Y., Okuyama, H., Brisibe, E., Saksena, N., Fujii, Y. (2004). Hiv-1 Nef Suppression By Virally Encoded Microrna. Retrovirology, 1, 44-55.
  • Zaunders, J., Dyer, W., Wang, B., Munier, M., Miranda Saksena, M., Newton, R., Moore, J., Mackay, C., Cooper, D., Saksena, N., et al (2004). Identification Of Circulating Antigen-Specific Cd4+ T Lymphocytes With A Ccr5+, Cytotoxic Phenotype In An Hiv-1 Long-Term Nonprogressor And In Cmv Infection. Blood, 103(6), 2238-2247.
  • Smit, T., Brew, B., Tourtellotte, W., Morgello, S., Gelman, B., Saksena, N. (2004). Independent Evolution Of Human Immunodeficiency Virus (Hiv) Drug Resistance Mutations In Diverse Areas Of The Brain In Hiv-Infected Patients, With And Without Dementia, On Antiretroviral Treatment. Journal of Virology, 78(18), 10133-10148.
  • Potter, S., Chew, C., Steain, M., Dwyer, D., Saksena, N. (2004). Obstacles To Successful Antiretroviral Treatment Of Hiv-1 Infection: Problems & Perspectives. Indian Journal of Medical Research, 119, 217-37.

2003

  • Potter, S., Dwyer, D., Saksena, N. (2003). Differential cellular distribution of HIV-1 drug resistance in vivo: evidence for infection of CD8+ T cells during HAART. Virology, 305(2), 339-352. [More Information]
  • Wang, B., Mikhail, M., Dyer, W., Zaunders, J., Kelleher, A., Saksena, N. (2003). First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetence HIV-1 infection. Virology, 312(1), 135-150.
  • Mikhail, M., Wang, B., Saksena, N. (2003). Mechanisms involved in non-progressive HIV disease. AIDS Reviews, (4), 230-244.
  • Herring, B., Ge, Y., Wang, B., Ratnamohan, M., Zheng, F., Cunningham, A., Saksena, N., Dwyer, D. (2003). Segregation of human immunodificiency virus type 1 subtypes by risk factor in Australia. Journal of Clinical Microbiology, 41(10), 4600-4604.
  • Lemey, P., Salemi, M., Wang, B., Duffy, M., Hall, W., Saksena, N., Vandamme, A. (2003). Site stripping based on likelihood ratio reduction is a useful tool fo evaluate the impact of non-clock-like behavior on viral phylogenetic reconstructions. FEMS Immunology and Medical Microbiology, 39(2), 125-132.
  • Lemey, P., Pybus, O., Wang, B., Saksena, N., Salemi, M., Vandamme, A. (2003). Tracing the origin and history of the HIV-2 epidemic. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 100(11), 6588-6592.

2001

  • Saksena, N., Cunningham, A., Birch,, M., Learmont, J., Dyer,, W., Deacon,, N., Zaunders, J., Mills,, J., Sullivan, J. (2001). An examination of signs of disease progression in survivors of the Sydney Blood Bank Cohort (SBBC). Journal of Virology, 22, 263-270.

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