Dr Nicholas Cole

Lecturer
Anatomy & Histology, School of Medical Sciences
Bosch Institute

F13 - Anderson Stuart Building
The University of Sydney
NSW 2006 Australia

T:	+61 2 9351 7629
F:	+61 2 9351 7629
E:

Themes

Reproductive, Maternal and Child Health; Obesity, Diabetes and Cardiovascular Disease; Healthy Ageing

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Biographical details

Cole NJ, Don, E, Hall TE, Berger, S, Neyt C, Ericsson R, Joss J, & Currie PD (2011). Evolutionary origins of vertebrate hind-limb musculature and the tetrapod transition. PLOS Biology, PLoS Biol. 2011 Oct;9(10) [More...]

Cole NJ, Don, E, Hall TE, Berger, S, Neyt C, Ericsson R, Joss J, & Currie PD (2011). Evolutionary origins of vertebrate hind-limb musculature and the tetrapod transition. PLOS Biology, PLoS Biol. 2011 Oct;9(10)

Don, E. K., Hall, T. E., Currie, P. D. and Cole, N. J. (2011), Morphology of pelvic fin loss in a zebrafish strain (Danio rerio). Journal of Morphology, 272: 583589.

Assinder, S., Cole, N.J. Does (2011). TGF-β induced formation of actin stress fibres reinforce Smad dependent TGF-β signalling in the prostate? Medical hypotheses. 2011; 76:802-4.

Bryson-Richardson, R. J., Berger, S., Schilling, T. F., Hall, T. E., Cole, N. J., Gibson, A. J., Sharpe, J. and Currie, P. D. (2007). FishNet: an online database of zebrafish anatomy. BMC Biol 5, 34.

Cole, N. J. and Currie, P. D. (2007). Insights from sharks: evolutionary and developmental models of fin development. Dev Dyn 236, 2421-31.

Hollway, G. E., Bryson-Richardson, R. J., Berger, S., Cole, N. J., Hall, T. E. and Currie, P. D. (2007). Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo. Dev Cell 12, 207-19.

Hall, T. E., Bryson-Richardson, R. J., Berger, S., Jacoby, A. S., Cole, N. J., Hollway, G. E., Berger, J. and Currie, P. D. (2007). The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin alpha2-deficient congenital muscular dystrophy. Proc Natl Acad Sci U S A 104, 7092-7.

Nihei, Y., Kobiyama, A., Ikeda, D., Ono, Y., Ohara, S., Cole, N. J., Johnston, I. A. and Watabe, S. (2006). Molecular cloning and mRNA expression analysis of carp embryonic, slow and cardiac myosin heavy chain isoforms. J Exp Biol 209, 188-98.

Cole, N. J., Hall, T. E., Martin, C. I., Chapman, M. A., Kobiyama, A., Nihei, Y., Watabe, S. and Johnston, I. A. (2004). Temperature and the expression of myogenic regulatory factors (MRFs) and myosin heavy chain isoforms during embryogenesis in the common carp Cyprinus carpio L. J Exp Biol 207, 4239-48.

Haines, L., Neyt, C., Gautier, P., Keenan, D. G., Bryson-Richardson, R. J., Hollway, G. E., Cole, N. J. and Currie, P. D. (2004). Met and Hgf signaling controls hypaxial muscle and lateral line development in the zebrafish. Development 131, 4857-69.

Tickle, C. and Cole, N. J. (2004). Morphological diversity: taking the spine out of three-spine stickleback. Curr Biol 14, R422-4.

Hall, T. E., Cole, N. J. and Johnston, I. A. (2003). Temperature and the expression of seven muscle-specific protein genes during embryogenesis in the Atlantic cod Gadus morhua L. J Exp Biol 206, 3187-200.

Cole, N. J., Tanaka, M., Prescott, A. and Tickle, C. (2003). Expression of limb initiation genes and clues to the morphological diversification of threespine stickleback. Curr Biol 13, R951-2.

Cole, N. J. and Johnston, I. A. (2001). Plasticity of myosin heavy chain expression with temperature acclimation is gradually acquired during ontogeny in the common carp (Cyprinus carpio L.). J Comp Physiol B 171, 321-6.

Temple, G. K., Cole, N. J. and Johnston, I. A. (2001). Embryonic temperature and the relative timing of muscle-specific genes during development in herring (Clupea harengus L.). J Exp Biol 204, 3629-37.

Wakeling, J. M., Cole, N. J., Kemp, K. M. and Johnston, I. A. (2000). The biomechanics and evolutionary significance of thermal acclimation in the common carp Cyprinus carpio. Am J Physiol Regul Integr Comp Physiol 279, R657-65.

James, R., Cole, N. and Davies, M. (1998). Scaling of intrinsic contractile properties and myofibrillar protein composition of fast muscle in the fish myoxocephalus scorpius L. J Exp Biol 201 (Pt 7), 901-12.

Johnston, I. I. and Cole, N. (1998). Embryonic temperature modulates muscle growth characteristics in larval and juvenile herring. J Exp Biol 201 (Pt 12), 623-46.

Johnston, I. I., Cole, N., Vieira, V. V. and Davidson, I. I. (1997). Temperature and developmental plasticity of muscle phenotype in herring larvae. J Exp Biol 200, 849-68. [Hide detail]

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Research interests

The overall aim of my research is to use the power of the zebrafish as a model vertebrate to understand normal development and function and to find potential cures of human disorders.

Zebrafish are our model organism, increadibly these small fish are an amazing system with which to answer many questions of human disease. My laboratory has a 'state of the art zebrafish facility'. In addition I examine sharks, paddlefish and lungfish for an evolutionary view point. I will provide an encouraging, interactive and enjoyable environment for you to development as a research scientist. I am very open to your own ideas and questions.

Current projects include but are not limited to;

MOTORNEURON DISEASE

Creating and curing fish models of human motorneuron disorders. In particular ALS

MUSCLE AND LIMB/FIN DEVELOPMENT AND EVOLUTION

Initiation, specification and control of vertebrate limb and muscle development .

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Current national competitive grants*

2012

Investigating the pathogenesis of motor neuron disease using zebrafish models
Cole N, Nicholson G, Blair I, Laird A
NHMRC Project Grants ($419,925 over 3 years)

* Grants administered through the University of Sydney

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