Dr Pablo Silveira

Senior Research Fellow
ANZAC Research Institute

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Biographical details

Dr Pablo Silveira is a team leader in the Dendritic Cell Research group at the ANZAC Research Institute. His research focus is on novel molecules on dendritic cells that can be used as therapeutic targets to control inflammation associated with haematopoietic stem cell transplantation or autoimmune disease.

Selected grants

2014

  • EVOS FL Auto cell imaging system; Nicholson G, Clark G, Zhou H, Jessup W, Le Couteur D, McMahon A, McLachlan A, Allan C, Handelsman D, Hart D, Walters K, Kritharides L, Kockx M, Kennerson M, Cooper M, Seibel M, Verma N, Silveira P, Fromm P, Simanainen U, Cogger V, Zheng Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2006

  • Identifying the underlying mechanisms responsible for the generation of pathogenic B cells in Type 1 Diabetes; Silveira P; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • The role of B lymphocytes in type 1 diabetes; Silveira P; Clive & Vera Ramaciotti Foundation/Research Grant.

2003

  • B cell tolerance defects as a potential contributor to Type i Diabetes; Silveira P; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Journals

  • Li, Z., Ju, X., Lee, K., Clarke, C., Hsu, J., Abadir, E., Bryant, C., Pears, S., Sunderland, N., Heffernan, S., Lo, T., Fromm, P., Silveira, P., Cooper, W., Brown, C., Clark, G., Hart, D., et al (2018). CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma. Haematologica, 103(4), 655-665. [More Information]
  • Shahin, K., Mattar, Z., Silveira, P., Hsu, W., Bendall, L., Hart, D., Bradstock, K. (2017). Bone Marrow Graft-Versus-Host Disease in Major Histocompatibility Complex-Matched Murine Reduced-Intensity Allogeneic Hemopoietic Cell Transplantation. Transplantation, 101(11), 2695-2704. [More Information]
  • Chu, E., Elso, C., Pollock, A., Alsayb, M., Mackin, L., Thomas, H., Kay, T., Silveira, P., Mansell, A., Gaus, K., et al (2017). Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility. Molecular Immunology, 82, 19-33. [More Information]
  • Bryant, C., Fromm, P., Kupresanin, F., Clark, G., Lee, K., Clarke, C., Silveira, P., Suen, H., Brown, R., Newman, E., Ho, P., Bradstock, K., Joshua, D., Hart, D., et al (2016). A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset. Immunology and Cell Biology, 94(5), 447-457. [More Information]
  • Lo, T., Silveira, P., Fromm, P., Verma, N., Vu, P., Kupresanin, F., Adam, R., Kato, M., Cogger, V., Clark, G., Hart, D. (2016). Characterization of the expression and function of the C-type lectin receptor CD302 in mice and humans reveals a role in dendritic cell migration. Journal of Immunology, 197(3), 885-898. [More Information]
  • Fromm, P., Papadimitrious, M., Hsu, J., Van Kooten Losio, N., Verma, N., Lo, T., Silveira, P., Bryant, C., Turtle, C., Prue, R., Horvath, L., Bradstock, K., Joshua, D., Clark, G., Hart, D., et al (2016). CMRF-56+ blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T-lymphocyte responses. OncoImmunology, 5(6), 1-12. [More Information]
  • Seldon, T., Pryor, R., Palkova, A., Jones, M., Verma, N., Findova, M., Braet, K., Sheng, Y., Fan, Y., Zhou, E., Fromm, P., Silveira, P., Elgundi, Z., Ju, X., Clark, G., Bradstock, K., Hart, D., et al (2016). Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation. Leukemia, 30(3), 692-700. [More Information]
  • Clark, G., Kupresanin, F., Fromm, P., Ju, X., Muusers, L., Silveira, P., Elgundi, Z., Gasiorowski, R., Papadimitrious, M., Bryant, C., Lee, K., Harman, A., Hart, D., et al (2016). New insights into the phenotype of human dendritic cell populations. Clinical & Translational Immunology, 5(1), 1-12. [More Information]
  • Ju, X., Silveira, P., Hsu, W., Elgundi, Z., Alingcastre, R., Verma, N., Fromm, P., Hsu, J., Bryant, C., Li, Z., Lo, T., Lee, K., Fazekas de St Groth, B., Larsen, S., Gibson, J., Bradstock, K., Clark, G., Hart, D., et al (2016). The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population. Journal of Immunology, 197(12), 4613-4625. [More Information]
  • Villanueva, J., Malle, E., Gardam, S., Silveira, P., Zammit, N., Walters, S., Brink, R., Grey, S. (2015). TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. European Journal of Immunology, 45(6), 1820-1831. [More Information]
  • McGuire, H., Vogelzang, A., Ma, C., Hughes, W., Silveira, P., Tangye, S., Christ, D., Fulcher, D., Falcone, M., King, C. (2011). A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity. Immunity, 34(4), 602-615. [More Information]
  • Marino, E., Silveira, P., Stolp, J., Grey, S. (2011). B cell-directed therapies in type 1 diabetes. Trends in Immunology, 32(6), 287-294. [More Information]
  • Basten, A., Silveira, P. (2010). B-cell tolerance: mechanisms and implications. Current Opinion in Immunology, 22(5), 566-574. [More Information]
  • Cox, S., Stolp, J., Hallahan, N., Counette, J., Zhang, W., Serreze, D., Basten, A., Silveira, P. (2010). Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a b-cell neo-self-antigen in type 1 diabetes prone NOD mice. European Journal of Immunology, 40(12), 3413-3425. [More Information]
  • Reifsnyder, P., Li, R., Silveira, P., Churchill, G., Serreze, D., Leiter, E. (2005). Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice. Genes and Immunity, 6(6), 528-538. [More Information]
  • Baxter, A., Jordan, M., Silveira, P., Wilson, W., Van Driel, I. (2005). Genetic control of susceptibility to autoimmune gastritis. International Reviews of Immunology, 24(01-Feb), 55-62. [More Information]
  • Poulton, L., Smyth, M., Hawke (Boulton), C., Silveira, P., Shepherd, D., Naidenko, O., Godfrey, D., Baxter, A. (2001). Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. International Immunology, 13(7), 887-896.
  • Silveira, P., Wilson, W., Esteban, L., Jordan, M., Hawke (Boulton), C., Van Driel, I., Baxter, A. (2001). Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analyses. Immunogenetics, 53(9), 741-750.

2018

  • Li, Z., Ju, X., Lee, K., Clarke, C., Hsu, J., Abadir, E., Bryant, C., Pears, S., Sunderland, N., Heffernan, S., Lo, T., Fromm, P., Silveira, P., Cooper, W., Brown, C., Clark, G., Hart, D., et al (2018). CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma. Haematologica, 103(4), 655-665. [More Information]

2017

  • Shahin, K., Mattar, Z., Silveira, P., Hsu, W., Bendall, L., Hart, D., Bradstock, K. (2017). Bone Marrow Graft-Versus-Host Disease in Major Histocompatibility Complex-Matched Murine Reduced-Intensity Allogeneic Hemopoietic Cell Transplantation. Transplantation, 101(11), 2695-2704. [More Information]
  • Chu, E., Elso, C., Pollock, A., Alsayb, M., Mackin, L., Thomas, H., Kay, T., Silveira, P., Mansell, A., Gaus, K., et al (2017). Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility. Molecular Immunology, 82, 19-33. [More Information]

2016

  • Bryant, C., Fromm, P., Kupresanin, F., Clark, G., Lee, K., Clarke, C., Silveira, P., Suen, H., Brown, R., Newman, E., Ho, P., Bradstock, K., Joshua, D., Hart, D., et al (2016). A CD2 high-expressing stress-resistant human plasmacytoid dendritic-cell subset. Immunology and Cell Biology, 94(5), 447-457. [More Information]
  • Lo, T., Silveira, P., Fromm, P., Verma, N., Vu, P., Kupresanin, F., Adam, R., Kato, M., Cogger, V., Clark, G., Hart, D. (2016). Characterization of the expression and function of the C-type lectin receptor CD302 in mice and humans reveals a role in dendritic cell migration. Journal of Immunology, 197(3), 885-898. [More Information]
  • Fromm, P., Papadimitrious, M., Hsu, J., Van Kooten Losio, N., Verma, N., Lo, T., Silveira, P., Bryant, C., Turtle, C., Prue, R., Horvath, L., Bradstock, K., Joshua, D., Clark, G., Hart, D., et al (2016). CMRF-56+ blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T-lymphocyte responses. OncoImmunology, 5(6), 1-12. [More Information]
  • Seldon, T., Pryor, R., Palkova, A., Jones, M., Verma, N., Findova, M., Braet, K., Sheng, Y., Fan, Y., Zhou, E., Fromm, P., Silveira, P., Elgundi, Z., Ju, X., Clark, G., Bradstock, K., Hart, D., et al (2016). Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation. Leukemia, 30(3), 692-700. [More Information]
  • Clark, G., Kupresanin, F., Fromm, P., Ju, X., Muusers, L., Silveira, P., Elgundi, Z., Gasiorowski, R., Papadimitrious, M., Bryant, C., Lee, K., Harman, A., Hart, D., et al (2016). New insights into the phenotype of human dendritic cell populations. Clinical & Translational Immunology, 5(1), 1-12. [More Information]
  • Ju, X., Silveira, P., Hsu, W., Elgundi, Z., Alingcastre, R., Verma, N., Fromm, P., Hsu, J., Bryant, C., Li, Z., Lo, T., Lee, K., Fazekas de St Groth, B., Larsen, S., Gibson, J., Bradstock, K., Clark, G., Hart, D., et al (2016). The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population. Journal of Immunology, 197(12), 4613-4625. [More Information]

2015

  • Villanueva, J., Malle, E., Gardam, S., Silveira, P., Zammit, N., Walters, S., Brink, R., Grey, S. (2015). TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15. European Journal of Immunology, 45(6), 1820-1831. [More Information]

2011

  • McGuire, H., Vogelzang, A., Ma, C., Hughes, W., Silveira, P., Tangye, S., Christ, D., Fulcher, D., Falcone, M., King, C. (2011). A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity. Immunity, 34(4), 602-615. [More Information]
  • Marino, E., Silveira, P., Stolp, J., Grey, S. (2011). B cell-directed therapies in type 1 diabetes. Trends in Immunology, 32(6), 287-294. [More Information]

2010

  • Basten, A., Silveira, P. (2010). B-cell tolerance: mechanisms and implications. Current Opinion in Immunology, 22(5), 566-574. [More Information]
  • Cox, S., Stolp, J., Hallahan, N., Counette, J., Zhang, W., Serreze, D., Basten, A., Silveira, P. (2010). Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a b-cell neo-self-antigen in type 1 diabetes prone NOD mice. European Journal of Immunology, 40(12), 3413-3425. [More Information]

2005

  • Reifsnyder, P., Li, R., Silveira, P., Churchill, G., Serreze, D., Leiter, E. (2005). Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice. Genes and Immunity, 6(6), 528-538. [More Information]
  • Baxter, A., Jordan, M., Silveira, P., Wilson, W., Van Driel, I. (2005). Genetic control of susceptibility to autoimmune gastritis. International Reviews of Immunology, 24(01-Feb), 55-62. [More Information]

2001

  • Poulton, L., Smyth, M., Hawke (Boulton), C., Silveira, P., Shepherd, D., Naidenko, O., Godfrey, D., Baxter, A. (2001). Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. International Immunology, 13(7), 887-896.
  • Silveira, P., Wilson, W., Esteban, L., Jordan, M., Hawke (Boulton), C., Van Driel, I., Baxter, A. (2001). Identification of the Gasa3 and Gasa4 autoimmune gastritis susceptibility genes using congenic mice and partitioned, segregative and interaction analyses. Immunogenetics, 53(9), 741-750.

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