Dr Patric Jansson

Research Fellow, Lecturer
Leader, Cancer Therapeutics and Drug Resistance Group
Molecular Pharmacology and Pathology Program

Telephone +61 2 9351 6150

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Selected grants

2016

  • Identification of the Specific Structure-Activity Relationships of Thiosemicarbazones To Overcome Multidrug Resistance by Exploiting Lysosomal Drug Pumps in Breast Cancer; Richardson D, Jansson P, Lee S, Bernhardt P, Bao B, Kovarikova P, Wand H; National Breast Cancer Foundation/Pilot Study Grants.

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Development of Novel Drugs for Prostate Cancer Treatment that Target the Lysosome; Jansson P; Prostate Cancer Foundation of Australia/PCFA Research Program.
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • A Novel Targeting Strategy for the Design of New Chemotherapeutics that Overcome Drug Resistance in Lung Cancer: High-Jacking the Drug Efflux Pump, P-gp; Jansson P; Cancer Institute New South Wales/Early Career Fellowship.

2009

  • Development of Novel Drugs for the Treatment of Breast Cancer; Jansson P, Richardson D, Lovejoy D, Kalinowski D; Australian Rotary Health/Research Support.

2008

  • Pre-Clinical Development of Second Generation DpT Iron Chelators for the Treatment of Melanoma; Richardson D, Jansson P; Cure Cancer Australia Foundation/Research Support.

Selected publications

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Journals

  • Lane, D., Jansson, P., Richardson, D. (2016). Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly. Aging, 8(5), 1150-1152.
  • Seebacher, N., Lane, D., Jansson, P., Richardson, D. (2016). Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter. The Journal of Biological Chemistry, 291(8), 3796-3820. [More Information]
  • Gutierrez, E., Seebacher, N., Arzuman, L., Kovacevic, Z., Lane, D., Richardson, V., Merlot, A., Lok, H., Kalinowski, D., Sahni, S., Jansson, P., Richardson, D. (2016). Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT). Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1863 (7 Pt A), 1665-1681. [More Information]
  • Merlot, A., Shafie, N., Yu, Y., Richardson, V., Jansson, P., Sahni, S., Lane, D., Kovacevic, Z., Kalinowski, D., Richardson, D. (2016). Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2?, IRE1?, ATF6 and calmodulin kinase. Biochemical Pharmacology, 109, 27-47. [More Information]
  • Al-Eisawi, Z., Stefani, C., Jansson, P., Arvind, A., Sharpe, P., Basha, M., Iskander, G., Kumar, N., Kovacevic, Z., Lane, D., Sahni, S., Richardson, D., Kalinowski, D., et al (2016). Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2‑Acetylpyridine 4,4-Dimethyl-3- selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. Journal of Medicinal Chemistry, 59(1), 294-312. [More Information]
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Richardson, D., et al (2016). Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1893 (4), 727-748. [More Information]
  • Paluncic, J., Kovacevic, Z., Jansson, P., Kalinowski, D., Merlot, A., Huang, M., Lok, H., Sahni, S., Lane, D., Richardson, D. (2016). Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1863 (4), 770-784. [More Information]
  • Sahni, S., Kovacevic, Z., Kalinowski, D., Huang, M., Menezes, S., Krishan, S., Lane, D., Jansson, P., Richardson, D. (2016). Targeting autophagy in antitumor agent design: Furthering the 'lysosomal love' strategy. Future Medicinal Chemistry, 8(7), 727-729. [More Information]
  • Seebacher, N., Lane, D., Richardson, D., Jansson, P. (2016). Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance. Free Radical Biology and Medicine, 96, 432-445. [More Information]
  • Stacy, A., Palanimuthu, D., Bernhardt, P., Kalinowski, D., Jansson, P., Richardson, D. (2016). Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity. Journal of Medicinal Chemistry, 59(10), 4965-4984. [More Information]
  • Lane, D., Merlot, A., Huang, M., Bae, D., Jansson, P., Sahni, S., Kalinowski, D., Richardson, D. (2015). Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochimica et Biophysica Acta. General Subjects, 1853 (5), 1130-1144. [More Information]
  • Jansson, P., Yamagishi, T., Arvind, A., Seebacher, N., Gutierrez, E., Stacy, A., Maleki, S., Sharp, D., Sahni, S., Richardson, D. (2015). Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp). The Journal of Biological Chemistry, 290(15), 9588-9603. [More Information]
  • Seebacher, N., Richardson, D., Jansson, P. (2015). Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics. British Journal of Pharmacology, 172(10), 2557-2772. [More Information]
  • Stefani, C., Al-Eisawi, Z., Jansson, P., Kalinowski, D., Richardson, D. (2015). Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization. Journal of Inorganic Biochemistry, 152, 20-37. [More Information]
  • Krishan, S., Jansson, P., Gutierrez, E., Lane, D., Richardson, D., Sahni, S. (2015). Iron metabolism and autophagy: A poorly explored relationship that has important consequences for health and disease. Nagoya Journal of Medical Science, 77, 1-6.
  • Merlot, A., Kalinowski, D., Kovacevic, Z., Jansson, P., Lane, D., Sahni, S., Huang, M., Richardson, D. (2015). Making a case for albumin - a highly promising drug-delivery system. Future Medicinal Chemistry, 7(5), 553-556. [More Information]
  • Liu, W., Kovacevic, Z., Peng, Z., Jin, R., Wang, P., Yue, F., Zheng, M., Huang, M., Jansson, P., Richardson, V., Kalinowski, D., Lane, D., Merlot, A., Sahni, S., Richardson, D. (2015). The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets. Oncotarget, 6(34), 35522-35541. [More Information]
  • Liu, W., Yue, F., Zheng, M., Merlot, A., Bae, D., Huang, M., Lane, D., Jansson, P., Liu, G., Richardson, V., Sahni, S., Kalinowski, D., Kovacevic, Z., Richardson, D. (2015). The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget, 6(11), 8851-8874.
  • Jansson, P., Kalinowski, D., Lane, D., Kovacevic, Z., Seebacher, N., Fouani, L., Sahni, S., Merlot, A., Richardson, D. (2015). The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones. Pharmacological Research, 100, 255-260. [More Information]
  • Sahni, S., Merlot, A., Krishnan, S., Jansson, P., Richardson, D. (2014). Gene of the month: BECN1. Journal of Clinical Pathology, 67(8), 656-660. [More Information]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1845 (1), 1-19. [More Information]
  • Gutierrez, E., Richardson, D., Jansson, P. (2014). The Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal Integrity. The Journal of Biological Chemistry, 289(48), 33568-33589. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. The Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]
  • Stefani, C., Jansson, P., Gutierrez, E., Bernhardt, P., Richardson, D., Kalinowski, D. (2013). Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation. Journal of Medicinal Chemistry, 56(1), 357-370. [More Information]
  • Ford, S., Obeidy, P., Lovejoy, D., Bedford, M., Nichols, L., Chadwick, C., Tucker, O., Lui, G., Kalinowski, D., Jansson, P., Richardson, D., et al (2013). Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. British Journal of Pharmacology, 168(6), 1316-1328. [More Information]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013). Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis, 34(9), 1943-1954. [More Information]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology, 183(3), 745-757. [More Information]
  • Stacy, A., Jansson, P., Richardson, D. (2013). Molecular Pharmacology of ABCG2 and Its Role in Chemoresistance. Molecular Pharmacology, 84(5), 655-669. [More Information]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013). P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. The Journal of Biological Chemistry, 288(44), 31761-31771. [More Information]
  • Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp, D., Jansson, P., Kalinowski, D., Kovacevic, Z., Lovejoy, D., Richardson, D. (2013). The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Molecular Pharmacology, 83(1), 179-190. [More Information]
  • Kalinowski, D., Jansson, P., Kovacevic, Z., Richardson, D. (2013). The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. Redox Report, 18(2), 48-50. [More Information]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013). The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology, 66(11), 911-917. [More Information]
  • Quach, P., Gutierrez, E., Basha, M., Kalinowski, D., Sharpe, P., Lovejoy, D., Bernhardt, P., Jansson, P., Richardson, D. (2012). Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect. Molecular Pharmacology, 82(1), 105-114. [More Information]
  • Lovejoy, D., Sharp, D., Seebacher, N., Obeidy, P., Prichard, T., Stefani, C., Basha, M., Sharpe, P., Jansson, P., Kalinowski, D., Richardson, D., et al (2012). Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry, 55(16), 7230-7244. [More Information]
  • Lovejoy, D., Jansson, P., Brunk, U., Wong, J., Ponka, P., Richardson, D. (2011). Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes. Cancer Research, 71(17), 5871-5880. [More Information]
  • Stefani, C., Punnia-Moorthy, G., Lovejoy, D., Jansson, P., Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2011). Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity. Journal of Medicinal Chemistry, 54(19), 6936-6948. [More Information]
  • Jansson, P., Sharpe, P., Bernhardt, P., Richardson, D. (2010). Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity. Journal of Medicinal Chemistry, 53(15), 5759-5769. [More Information]
  • Jansson, P., Hawkins, C., Lovejoy, D., Richardson, D. (2010). The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study. Journal of Inorganic Biochemistry, 104(11), 1224-1228. [More Information]
  • Richardson, D., Kalinowski, D., Lau, S., Jansson, P., Lovejoy, D. (2009). Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochimica et Biophysica Acta, 1790 (7), 702-717. [More Information]
  • Mladenka, P., Kalinowski, D., Haskova, P., Bobrovova, Z., Hrdina, R., Simunek, T., Nachtigal, P., Semecky, V., Vavrova, J., Holeckova, M., Jansson, P., Richardson, D., et al (2009). The Novel Iron Chelator, 2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl Hydrazone, Reduces Catecholamine-Mediated Myocardial Toxicity. Chemical Research in Toxicology, 22(1), 208-217. [More Information]
  • Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas, A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe, P., Bernhardt, P., Richardson, D. (2009). Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of Medicinal Chemistry, 52(17), 5271-5294. [More Information]
  • Jansson, P., Del Castillo, U., Lindqvist, C., Nordstrom, T. (2005). Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water. Free Radical Research, 39(5), 565-570.
  • Jansson, P., Lindqvist, C., Nordstrom, T. (2005). Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water. Free Radical Research, 39(11), 1233-1239.
  • Jansson, P., Jung, H., Lindqvist, C., Nordstrom, T. (2004). Oxidative Decomposition of Vitamin C in Drinking Water. Free Radical Research, 38(8), 855-860.
  • Jansson, P., Asplund, K., Makela, J., Lindqvist, C., Nordstrom, T. (2003). Vitamin C (Ascorbic Acid) Induced Hydroxyl Radical Formation in Copper Contaminated Household Drinking Water: Role of Bicarbonate Concentration. Free Radical Research, 37(8), 901-905.

2016

  • Lane, D., Jansson, P., Richardson, D. (2016). Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly. Aging, 8(5), 1150-1152.
  • Seebacher, N., Lane, D., Jansson, P., Richardson, D. (2016). Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter. The Journal of Biological Chemistry, 291(8), 3796-3820. [More Information]
  • Gutierrez, E., Seebacher, N., Arzuman, L., Kovacevic, Z., Lane, D., Richardson, V., Merlot, A., Lok, H., Kalinowski, D., Sahni, S., Jansson, P., Richardson, D. (2016). Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT). Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1863 (7 Pt A), 1665-1681. [More Information]
  • Merlot, A., Shafie, N., Yu, Y., Richardson, V., Jansson, P., Sahni, S., Lane, D., Kovacevic, Z., Kalinowski, D., Richardson, D. (2016). Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2?, IRE1?, ATF6 and calmodulin kinase. Biochemical Pharmacology, 109, 27-47. [More Information]
  • Al-Eisawi, Z., Stefani, C., Jansson, P., Arvind, A., Sharpe, P., Basha, M., Iskander, G., Kumar, N., Kovacevic, Z., Lane, D., Sahni, S., Richardson, D., Kalinowski, D., et al (2016). Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2‑Acetylpyridine 4,4-Dimethyl-3- selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. Journal of Medicinal Chemistry, 59(1), 294-312. [More Information]
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Richardson, D., et al (2016). Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1893 (4), 727-748. [More Information]
  • Paluncic, J., Kovacevic, Z., Jansson, P., Kalinowski, D., Merlot, A., Huang, M., Lok, H., Sahni, S., Lane, D., Richardson, D. (2016). Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1863 (4), 770-784. [More Information]
  • Sahni, S., Kovacevic, Z., Kalinowski, D., Huang, M., Menezes, S., Krishan, S., Lane, D., Jansson, P., Richardson, D. (2016). Targeting autophagy in antitumor agent design: Furthering the 'lysosomal love' strategy. Future Medicinal Chemistry, 8(7), 727-729. [More Information]
  • Seebacher, N., Lane, D., Richardson, D., Jansson, P. (2016). Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance. Free Radical Biology and Medicine, 96, 432-445. [More Information]
  • Stacy, A., Palanimuthu, D., Bernhardt, P., Kalinowski, D., Jansson, P., Richardson, D. (2016). Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity. Journal of Medicinal Chemistry, 59(10), 4965-4984. [More Information]

2015

  • Lane, D., Merlot, A., Huang, M., Bae, D., Jansson, P., Sahni, S., Kalinowski, D., Richardson, D. (2015). Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochimica et Biophysica Acta. General Subjects, 1853 (5), 1130-1144. [More Information]
  • Jansson, P., Yamagishi, T., Arvind, A., Seebacher, N., Gutierrez, E., Stacy, A., Maleki, S., Sharp, D., Sahni, S., Richardson, D. (2015). Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp). The Journal of Biological Chemistry, 290(15), 9588-9603. [More Information]
  • Seebacher, N., Richardson, D., Jansson, P. (2015). Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics. British Journal of Pharmacology, 172(10), 2557-2772. [More Information]
  • Stefani, C., Al-Eisawi, Z., Jansson, P., Kalinowski, D., Richardson, D. (2015). Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization. Journal of Inorganic Biochemistry, 152, 20-37. [More Information]
  • Krishan, S., Jansson, P., Gutierrez, E., Lane, D., Richardson, D., Sahni, S. (2015). Iron metabolism and autophagy: A poorly explored relationship that has important consequences for health and disease. Nagoya Journal of Medical Science, 77, 1-6.
  • Merlot, A., Kalinowski, D., Kovacevic, Z., Jansson, P., Lane, D., Sahni, S., Huang, M., Richardson, D. (2015). Making a case for albumin - a highly promising drug-delivery system. Future Medicinal Chemistry, 7(5), 553-556. [More Information]
  • Liu, W., Kovacevic, Z., Peng, Z., Jin, R., Wang, P., Yue, F., Zheng, M., Huang, M., Jansson, P., Richardson, V., Kalinowski, D., Lane, D., Merlot, A., Sahni, S., Richardson, D. (2015). The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets. Oncotarget, 6(34), 35522-35541. [More Information]
  • Liu, W., Yue, F., Zheng, M., Merlot, A., Bae, D., Huang, M., Lane, D., Jansson, P., Liu, G., Richardson, V., Sahni, S., Kalinowski, D., Kovacevic, Z., Richardson, D. (2015). The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget, 6(11), 8851-8874.
  • Jansson, P., Kalinowski, D., Lane, D., Kovacevic, Z., Seebacher, N., Fouani, L., Sahni, S., Merlot, A., Richardson, D. (2015). The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones. Pharmacological Research, 100, 255-260. [More Information]

2014

  • Sahni, S., Merlot, A., Krishnan, S., Jansson, P., Richardson, D. (2014). Gene of the month: BECN1. Journal of Clinical Pathology, 67(8), 656-660. [More Information]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1845 (1), 1-19. [More Information]
  • Gutierrez, E., Richardson, D., Jansson, P. (2014). The Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal Integrity. The Journal of Biological Chemistry, 289(48), 33568-33589. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. The Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]

2013

  • Stefani, C., Jansson, P., Gutierrez, E., Bernhardt, P., Richardson, D., Kalinowski, D. (2013). Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation. Journal of Medicinal Chemistry, 56(1), 357-370. [More Information]
  • Ford, S., Obeidy, P., Lovejoy, D., Bedford, M., Nichols, L., Chadwick, C., Tucker, O., Lui, G., Kalinowski, D., Jansson, P., Richardson, D., et al (2013). Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. British Journal of Pharmacology, 168(6), 1316-1328. [More Information]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013). Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis, 34(9), 1943-1954. [More Information]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology, 183(3), 745-757. [More Information]
  • Stacy, A., Jansson, P., Richardson, D. (2013). Molecular Pharmacology of ABCG2 and Its Role in Chemoresistance. Molecular Pharmacology, 84(5), 655-669. [More Information]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013). P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. The Journal of Biological Chemistry, 288(44), 31761-31771. [More Information]
  • Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp, D., Jansson, P., Kalinowski, D., Kovacevic, Z., Lovejoy, D., Richardson, D. (2013). The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Molecular Pharmacology, 83(1), 179-190. [More Information]
  • Kalinowski, D., Jansson, P., Kovacevic, Z., Richardson, D. (2013). The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. Redox Report, 18(2), 48-50. [More Information]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013). The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology, 66(11), 911-917. [More Information]

2012

  • Quach, P., Gutierrez, E., Basha, M., Kalinowski, D., Sharpe, P., Lovejoy, D., Bernhardt, P., Jansson, P., Richardson, D. (2012). Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect. Molecular Pharmacology, 82(1), 105-114. [More Information]
  • Lovejoy, D., Sharp, D., Seebacher, N., Obeidy, P., Prichard, T., Stefani, C., Basha, M., Sharpe, P., Jansson, P., Kalinowski, D., Richardson, D., et al (2012). Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry, 55(16), 7230-7244. [More Information]

2011

  • Lovejoy, D., Jansson, P., Brunk, U., Wong, J., Ponka, P., Richardson, D. (2011). Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes. Cancer Research, 71(17), 5871-5880. [More Information]
  • Stefani, C., Punnia-Moorthy, G., Lovejoy, D., Jansson, P., Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2011). Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity. Journal of Medicinal Chemistry, 54(19), 6936-6948. [More Information]

2010

  • Jansson, P., Sharpe, P., Bernhardt, P., Richardson, D. (2010). Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity. Journal of Medicinal Chemistry, 53(15), 5759-5769. [More Information]
  • Jansson, P., Hawkins, C., Lovejoy, D., Richardson, D. (2010). The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study. Journal of Inorganic Biochemistry, 104(11), 1224-1228. [More Information]

2009

  • Richardson, D., Kalinowski, D., Lau, S., Jansson, P., Lovejoy, D. (2009). Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochimica et Biophysica Acta, 1790 (7), 702-717. [More Information]
  • Mladenka, P., Kalinowski, D., Haskova, P., Bobrovova, Z., Hrdina, R., Simunek, T., Nachtigal, P., Semecky, V., Vavrova, J., Holeckova, M., Jansson, P., Richardson, D., et al (2009). The Novel Iron Chelator, 2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl Hydrazone, Reduces Catecholamine-Mediated Myocardial Toxicity. Chemical Research in Toxicology, 22(1), 208-217. [More Information]
  • Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas, A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe, P., Bernhardt, P., Richardson, D. (2009). Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of Medicinal Chemistry, 52(17), 5271-5294. [More Information]

2005

  • Jansson, P., Del Castillo, U., Lindqvist, C., Nordstrom, T. (2005). Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water. Free Radical Research, 39(5), 565-570.
  • Jansson, P., Lindqvist, C., Nordstrom, T. (2005). Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water. Free Radical Research, 39(11), 1233-1239.

2004

  • Jansson, P., Jung, H., Lindqvist, C., Nordstrom, T. (2004). Oxidative Decomposition of Vitamin C in Drinking Water. Free Radical Research, 38(8), 855-860.

2003

  • Jansson, P., Asplund, K., Makela, J., Lindqvist, C., Nordstrom, T. (2003). Vitamin C (Ascorbic Acid) Induced Hydroxyl Radical Formation in Copper Contaminated Household Drinking Water: Role of Bicarbonate Concentration. Free Radical Research, 37(8), 901-905.

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