Dr Patric Jansson

Research Fellow
Pathology, School of Medical Sciences

Telephone +61 2 9036 7120

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Honours project opportunities

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • Development of Novel Drugs for Prostate Cancer Treatment that Target the Lysosome; Jansson P; Prostate Cancer Foundation of Australia/Young Investigator Grants.
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • A Novel Targeting Strategy for the Design of New Chemotherapeutics that Overcome Drug Resistance in Lung Cancer: High-Jacking the Drug Efflux Pump, P-gp; Jansson P; Cancer Institute New South Wales/Early Career Development Fellowship.

2009

  • Development of Novel Drugs for the Treatment of Breast Cancer; Jansson P, Richardson D, Lovejoy D, Kalinowski D; Australian Rotary Health Research Fund/Research Support.

2008

  • Pre-Clinical Development of Second Generation DpT Iron Chelators for the Treatment of Melanoma; Richardson D, Jansson P; Cure Cancer Australia Foundation/Research Support.

Selected publications

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Journals

  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1845 (1), 1-19. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. The Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]
  • Stefani, C., Jansson, P., Gutierrez, E., Bernhardt, P., Richardson, D., Kalinowski, D. (2013). Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation. Journal of Medicinal Chemistry, 56(1), 357-370. [More Information]
  • Ford, S., Obeidy, P., Lovejoy, D., Bedford, M., Nichols, L., Chadwick, C., Tucker, O., Lui, G., Kalinowski, D., Jansson, P., Richardson, D., et al (2013). Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. British Journal of Pharmacology, 168(6), 1316-1328. [More Information]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013). Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis, 34(9), 1943-1954. [More Information]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology: cellular and molecular biology of disease, 183(3), 745-757. [More Information]
  • Stacy, A., Jansson, P., Richardson, D. (2013). Molecular Pharmacology of ABCG2 and Its Role in Chemoresistance. Molecular Pharmacology, 84(5), 655-669. [More Information]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013). P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. The Journal of Biological Chemistry, 288(44), 31761-31771. [More Information]
  • Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp, D., Jansson, P., Kalinowski, D., Kovacevic, Z., Lovejoy, D., Richardson, D. (2013). The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Molecular Pharmacology, 83(1), 179-190. [More Information]
  • Kalinowski, D., Jansson, P., Kovacevic, Z., Richardson, D. (2013). The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. Redox Report, 18(2), 48-50. [More Information]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013). The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology, 66(11), 911-917. [More Information]
  • Quach, P., Gutierrez, E., Basha, M., Kalinowski, D., Sharpe, P., Lovejoy, D., Bernhardt, P., Jansson, P., Richardson, D. (2012). Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect. Molecular Pharmacology, 82(1), 105-114. [More Information]
  • Lovejoy, D., Sharp, D., Seebacher, N., Obeidy, P., Prichard, T., Stefani, C., Basha, M., Sharpe, P., Jansson, P., Kalinowski, D., Richardson, D., et al (2012). Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry, 55(16), 7230-7244. [More Information]
  • Lovejoy, D., Jansson, P., Brunk, U., Wong, J., Ponka, P., Richardson, D. (2011). Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes. Cancer Research, 71(17), 5871-5880. [More Information]
  • Stefani, C., Punnia-Moorthy, G., Lovejoy, D., Jansson, P., Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2011). Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity. Journal of Medicinal Chemistry, 54(19), 6936-6948. [More Information]
  • Jansson, P., Sharpe, P., Bernhardt, P., Richardson, D. (2010). Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity. Journal of Medicinal Chemistry, 53(15), 5759-5769. [More Information]
  • Jansson, P., Hawkins, C., Lovejoy, D., Richardson, D. (2010). The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study. Journal of Inorganic Biochemistry, 104(11), 1224-1228. [More Information]
  • Richardson, D., Kalinowski, D., Lau, S., Jansson, P., Lovejoy, D. (2009). Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. BBA - Bioenergetics, 1790 (7), 702-717. [More Information]
  • Mladenka, P., Kalinowski, D., Haskova, P., Bobrovova, Z., Hrdina, R., Simunek, T., Nachtigal, P., Semecky, V., Vavrova, J., Holeckova, M., Jansson, P., Richardson, D., et al (2009). The Novel Iron Chelator, 2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl Hydrazone, Reduces Catecholamine-Mediated Myocardial Toxicity. Chemical Research in Toxicology, 22(1), 208-217. [More Information]
  • Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas, A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe, P., Bernhardt, P., Richardson, D. (2009). Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of Medicinal Chemistry, 52(17), 5271-5294. [More Information]
  • Jansson, P., Del Castillo, U., Lindqvist, C., Nordstrom, T. (2005). Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water. Free Radical Research, 39(5), 565-570.
  • Jansson, P., Lindqvist, C., Nordstrom, T. (2005). Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water. Free Radical Research, 39(11), 1233-1239.
  • Jansson, P., Jung, H., Lindqvist, C., Nordstrom, T. (2004). Oxidative Decomposition of Vitamin C in Drinking Water. Free Radical Research, 38(8), 855-860.
  • Jansson, P., Asplund, K., Makela, J., Lindqvist, C., Nordstrom, T. (2003). Vitamin C (Ascorbic Acid) Induced Hydroxyl Radical Formation in Copper Contaminated Household Drinking Water: Role of Bicarbonate Concentration. Free Radical Research, 37(8), 901-905.

2014

  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1845 (1), 1-19. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. The Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]

2013

  • Stefani, C., Jansson, P., Gutierrez, E., Bernhardt, P., Richardson, D., Kalinowski, D. (2013). Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation. Journal of Medicinal Chemistry, 56(1), 357-370. [More Information]
  • Ford, S., Obeidy, P., Lovejoy, D., Bedford, M., Nichols, L., Chadwick, C., Tucker, O., Lui, G., Kalinowski, D., Jansson, P., Richardson, D., et al (2013). Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. British Journal of Pharmacology, 168(6), 1316-1328. [More Information]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013). Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis, 34(9), 1943-1954. [More Information]
  • Huang, M., Sivagurunathan, S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. The American Journal of Pathology: cellular and molecular biology of disease, 183(3), 745-757. [More Information]
  • Stacy, A., Jansson, P., Richardson, D. (2013). Molecular Pharmacology of ABCG2 and Its Role in Chemoresistance. Molecular Pharmacology, 84(5), 655-669. [More Information]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013). P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. The Journal of Biological Chemistry, 288(44), 31761-31771. [More Information]
  • Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp, D., Jansson, P., Kalinowski, D., Kovacevic, Z., Lovejoy, D., Richardson, D. (2013). The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Molecular Pharmacology, 83(1), 179-190. [More Information]
  • Kalinowski, D., Jansson, P., Kovacevic, Z., Richardson, D. (2013). The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. Redox Report, 18(2), 48-50. [More Information]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013). The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology, 66(11), 911-917. [More Information]

2012

  • Quach, P., Gutierrez, E., Basha, M., Kalinowski, D., Sharpe, P., Lovejoy, D., Bernhardt, P., Jansson, P., Richardson, D. (2012). Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect. Molecular Pharmacology, 82(1), 105-114. [More Information]
  • Lovejoy, D., Sharp, D., Seebacher, N., Obeidy, P., Prichard, T., Stefani, C., Basha, M., Sharpe, P., Jansson, P., Kalinowski, D., Richardson, D., et al (2012). Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry, 55(16), 7230-7244. [More Information]

2011

  • Lovejoy, D., Jansson, P., Brunk, U., Wong, J., Ponka, P., Richardson, D. (2011). Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes. Cancer Research, 71(17), 5871-5880. [More Information]
  • Stefani, C., Punnia-Moorthy, G., Lovejoy, D., Jansson, P., Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2011). Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity. Journal of Medicinal Chemistry, 54(19), 6936-6948. [More Information]

2010

  • Jansson, P., Sharpe, P., Bernhardt, P., Richardson, D. (2010). Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity. Journal of Medicinal Chemistry, 53(15), 5759-5769. [More Information]
  • Jansson, P., Hawkins, C., Lovejoy, D., Richardson, D. (2010). The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study. Journal of Inorganic Biochemistry, 104(11), 1224-1228. [More Information]

2009

  • Richardson, D., Kalinowski, D., Lau, S., Jansson, P., Lovejoy, D. (2009). Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. BBA - Bioenergetics, 1790 (7), 702-717. [More Information]
  • Mladenka, P., Kalinowski, D., Haskova, P., Bobrovova, Z., Hrdina, R., Simunek, T., Nachtigal, P., Semecky, V., Vavrova, J., Holeckova, M., Jansson, P., Richardson, D., et al (2009). The Novel Iron Chelator, 2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl Hydrazone, Reduces Catecholamine-Mediated Myocardial Toxicity. Chemical Research in Toxicology, 22(1), 208-217. [More Information]
  • Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas, A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe, P., Bernhardt, P., Richardson, D. (2009). Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of Medicinal Chemistry, 52(17), 5271-5294. [More Information]

2005

  • Jansson, P., Del Castillo, U., Lindqvist, C., Nordstrom, T. (2005). Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water. Free Radical Research, 39(5), 565-570.
  • Jansson, P., Lindqvist, C., Nordstrom, T. (2005). Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water. Free Radical Research, 39(11), 1233-1239.

2004

  • Jansson, P., Jung, H., Lindqvist, C., Nordstrom, T. (2004). Oxidative Decomposition of Vitamin C in Drinking Water. Free Radical Research, 38(8), 855-860.

2003

  • Jansson, P., Asplund, K., Makela, J., Lindqvist, C., Nordstrom, T. (2003). Vitamin C (Ascorbic Acid) Induced Hydroxyl Radical Formation in Copper Contaminated Household Drinking Water: Role of Bicarbonate Concentration. Free Radical Research, 37(8), 901-905.

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