Dr Patric Jansson

Cancer Institute NSW Career Development Fellow Lecturer &
Leader, Cancer Drug Resistance Group Pathology, School of Medical Sciences

Telephone +61 2 90363031

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Current research students

Project title Research student
The Metastasis Suppressor, NDRG1, as a Novel Molecular Target for the Treatment of Aggressive Breast Cancer Faten (SHEHADEH TOUT)
Molecular Functions of NDRG1 as Metastasis Suppressor in Prostate Cancer Syer Choon LIM
Pharmacological Targeting of Oncogenic and Tumour Suppressive Pathways, and their Interaction with the Tumour Microenvironment in Pancreatic Cancer using the Metastasis Suppressor, NDRG1 Bekesho Geleta WENDIMU
Investigating the effect of novel thiosemicarbazones on FGFR and VEGFR expression and activity in breast cancer sub-types Madiha YUNUS

Cancer Drug Resistance Group

Head: Dr. Patric Jansson

Members:Lina Al-Akra (PhD student)

Lionel Leck (PhD student)

Syer Choon Lim(PhD student)

Bekesho Geleta Wendimuf(PhD student)

Faten Shehadeh Tout(PhD student)

Sundus Maqbool (PhD student)

Madiha Yunus(PhD student)

Dr. Laila Arzuman

Dr. Dong-Hun Bae

Selected grants

2018

  • To Biochemically Tricking P-Glycoprotein (Pgp) to Target Resistance via Lysosomal Pgp; Richardson D, Bernhardt P, Jansson P, Kalinowski D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Development of Innovative Chemotherapeutics that Target P-Glycoprotein-Expressing Cancers to Overcome Drug Resistance; Jansson P, Richardson D; Cancer Institute New South Wales/Career Development Fellowship.

2017

  • Development of Novel Agents that Target P-Glycoprotein Resistant Pancreatic Cancer; Richardson D, Jansson P, Kalinowski D, Sahni S; Avner Pancreatic Cancer Foundation/Research support.

2016

  • Identification of the Specific Structure-Activity Relationships of Thiosemicarbazones To Overcome Multidrug Resistance by Exploiting Lysosomal Drug Pumps in Breast Cancer; Richardson D, Jansson P, Lee S, Bernhardt P, Bao B, Kovarikova P, Wand H; National Breast Cancer Foundation/Pilot Study Grants.

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho P, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho P, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Development of Novel Drugs for Prostate Cancer Treatment that Target the Lysosome; Jansson P; Prostate Cancer Foundation of Australia/PCFA Research Program.

2011

  • A Novel Targeting Strategy for the Design of New Chemotherapeutics that Overcome Drug Resistance in Lung Cancer: High-Jacking the Drug Efflux Pump, P-gp; Jansson P; Cancer Institute New South Wales/Early Career Fellowship.

2009

  • Development of Novel Drugs for the Treatment of Breast Cancer; Jansson P, Richardson D, Lovejoy D, Kalinowski D; Australian Rotary Health/Research Support.

2008

  • Pre-Clinical Development of Second Generation DpT Iron Chelators for the Treatment of Melanoma; Richardson D, Jansson P; Cure Cancer Australia Foundation/Research Support.

Selected publications

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Journals

  • Lane, D., Bae, D., Siafakas, A., Rahmanto, Y., Al-Akra, L., Jansson, P., Casero Jr., R., Richardson, D. (2018). Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1864 (9 Part B), 2793-2813. [More Information]
  • Park, K., Menezes, S., Kalinowski, D., Sahni, S., Jansson, P., Kovacevic, Z., Richardson, D. (2018). Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1864 (8), 2644-2663. [More Information]
  • Chiang, S., Kalinowski, D., Jansson, P., Richardson, D., Huang, M. (2018). Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia. Neurochemistry International, 117, 35-48. [More Information]
  • Palanimuthu, D., Wu, Z., Jansson, P., Braidy, N., Bernhardt, P., Richardson, D., Kalinowski, D. (2018). Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease. Dalton Transactions, 47(21), 7190-7205. [More Information]
  • Bae, D., Lane, D., Jansson, P., Richardson, D. (2018). The old and new biochemistry of polyamines. Biochimica et Biophysica Acta - General Subjects, 1862 (9), 2053-2068. [More Information]
  • Al-Akra, L., Bae, D., Sahni, S., Huang, M., Park, K., Lane, D., Jansson, P., Richardson, D. (2018). Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones. Journal of Biological Chemistry, 293(10), 3562-3587. [More Information]
  • Sahni, S., Bae, D., Jansson, P., Richardson, D. (2017). The mechanistic role of chemically diverse metal ions in the induction of autophagy. Pharmacological Research, 119, 118-127. [More Information]
  • Seebacher, N., Richardson, D., Jansson, P. (2016). A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC. Cell Death and Disease, 7(12), 1-13. [More Information]
  • Lok, H., Sahni, S., Jansson, P., Kovacevic, Z., Hawkins, C., Richardson, D. (2016). A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity. Journal of Biological Chemistry, 291(53), 27042-27061. [More Information]
  • Lane, D., Jansson, P., Richardson, D. (2016). Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly. Aging, 8(5), 1150-1152.
  • Park, K., Fouani, L., Jansson, P., Wooi, D., Sahni, S., Lane, D., Palanimuthu, D., Lok, H., Kovacevic, Z., Huang, M., Kalinowski, D., Richardson, D. (2016). Copper and conquer: Copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics. Metallomics, 8(9), 874-886. [More Information]
  • Seebacher, N., Lane, D., Jansson, P., Richardson, D. (2016). Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter. Journal of Biological Chemistry, 291(8), 3796-3820. [More Information]
  • Klionsky, D., Abdelmohsen, K., Akihisa, A., Abedin, M., Abeliovich, H., Acevedo-Arozena, A., Arozena, H., Adams, C., Adams, P., et al, Sue, C., Mihailidou, A., Bae, D., Gutierrez, E., Jansson, P., Lane, D., Merlot, A., Richardson, D., Sahni, S. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222. [More Information]
  • Gutierrez, E., Seebacher, N., Arzuman, L., Kovacevic, Z., Lane, D., Richardson, V., Merlot, A., Lok, H., Kalinowski, D., Sahni, S., Jansson, P., Richardson, D. (2016). Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT). Biochimica et Biophysica Acta, 1863 (7 Pt A), 1665-1681. [More Information]
  • Merlot, A., Shafie, N., Yu, Y., Richardson, V., Jansson, P., Sahni, S., Lane, D., Kovacevic, Z., Kalinowski, D., Richardson, D. (2016). Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2[alpha], IRE1[alpha], ATF6 and calmodulin kinase. Biochemical Pharmacology, 109, 27-47. [More Information]
  • Al-Eisawi, Z., Stefani, C., Jansson, P., Arvind, A., Sharpe, P., Basha, M., Iskander, G., Kumar, N., Kovacevic, Z., Lane, D., Sahni, S., Richardson, D., Kalinowski, D., et al (2016). Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3- selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. Journal of Medicinal Chemistry, 59(1), 294-312. [More Information]
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Richardson, D., et al (2016). Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta, 1863 (4), 727-748. [More Information]
  • Paluncic, J., Kovacevic, Z., Jansson, P., Kalinowski, D., Merlot, A., Huang, M., Lok, H., Sahni, S., Lane, D., Richardson, D. (2016). Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling. Biochimica et Biophysica Acta, 1863 (4), 770-784. [More Information]
  • Stacy, A., Palanimuthu, D., Bernhardt, P., Kalinowski, D., Jansson, P., Richardson, D. (2016). Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. Journal of Medicinal Chemistry, 59(18), 8601-8620. [More Information]
  • Sahni, S., Kovacevic, Z., Kalinowski, D., Huang, M., Menezes, S., Krishan, S., Lane, D., Jansson, P., Richardson, D. (2016). Targeting autophagy in antitumor agent design: Furthering the 'lysosomal love' strategy. Future Medicinal Chemistry, 8(7), 727-729. [More Information]
  • Seebacher, N., Lane, D., Richardson, D., Jansson, P. (2016). Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance. Free Radical Biology and Medicine, 96, 432-445. [More Information]
  • Stacy, A., Palanimuthu, D., Bernhardt, P., Kalinowski, D., Jansson, P., Richardson, D. (2016). Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity. Journal of Medicinal Chemistry, 59(10), 4965-4984. [More Information]
  • Lane, D., Merlot, A., Huang, M., Bae, D., Jansson, P., Sahni, S., Kalinowski, D., Richardson, D. (2015). Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochimica et Biophysica Acta - General Subjects, 1853 (5), 1130-1144. [More Information]
  • Jansson, P., Yamagishi, T., Arvind, A., Seebacher, N., Gutierrez, E., Stacy, A., Maleki, S., Sharp, D., Sahni, S., Richardson, D. (2015). Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp). Journal of Biological Chemistry, 290(15), 9588-9603. [More Information]
  • Seebacher, N., Richardson, D., Jansson, P. (2015). Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics. British Journal of Pharmacology, 172(10), 2557-2772. [More Information]
  • Stefani, C., Al-Eisawi, Z., Jansson, P., Kalinowski, D., Richardson, D. (2015). Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization. Journal of Inorganic Biochemistry, 152, 20-37. [More Information]
  • Krishan, S., Jansson, P., Gutierrez, E., Lane, D., Richardson, D., Sahni, S. (2015). Iron metabolism and autophagy: A poorly explored relationship that has important consequences for health and disease. Nagoya Journal of Medical Science, 77, 1-6.
  • Merlot, A., Kalinowski, D., Kovacevic, Z., Jansson, P., Lane, D., Sahni, S., Huang, M., Richardson, D. (2015). Making a case for albumin - a highly promising drug-delivery system. Future Medicinal Chemistry, 7(5), 553-556. [More Information]
  • Liu, W., Kovacevic, Z., Peng, Z., Jin, R., Wang, P., Yue, F., Zheng, M., Huang, M., Jansson, P., Richardson, V., Kalinowski, D., Lane, D., Merlot, A., Sahni, S., Richardson, D. (2015). The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets. Oncotarget, 6(34), 35522-35541. [More Information]
  • Liu, W., Yue, F., Zheng, M., Merlot, A., Bae, D., Huang, M., Lane, D., Jansson, P., Lui, G., Richardson, V., Sahni, S., Kalinowski, D., Kovacevic, Z., Richardson, D. (2015). The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget, 6(11), 8851-8874. [More Information]
  • Jansson, P., Kalinowski, D., Lane, D., Kovacevic, Z., Seebacher, N., Fouani, L., Sahni, S., Merlot, A., Richardson, D. (2015). The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones. Pharmacological Research, 100, 255-260. [More Information]
  • Sahni, S., Merlot, A., Krishnan, S., Jansson, P., Richardson, D. (2014). Gene of the month: BECN1. Journal of Clinical Pathology, 67(8), 656-660. [More Information]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1845 (1), 1-19. [More Information]
  • Gutierrez, E., Richardson, D., Jansson, P. (2014). The Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal Integrity. Journal of Biological Chemistry, 289(48), 33568-33589. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]
  • Stefani, C., Jansson, P., Gutierrez, E., Bernhardt, P., Richardson, D., Kalinowski, D. (2013). Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation. Journal of Medicinal Chemistry, 56(1), 357-370. [More Information]
  • Ford, S., Obeidy, P., Lovejoy, D., Bedford, M., Nichols, L., Chadwick, C., Tucker, O., Lui, G., Kalinowski, D., Jansson, P., Richardson, D., et al (2013). Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. British Journal of Pharmacology, 168(6), 1316-1328. [More Information]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013). Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis, 34(9), 1943-1954. [More Information]
  • Huang, M., Ramesh (Sivagurunathan), S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. American Journal of Pathology, 183(3), 745-757. [More Information]
  • Stacy, A., Jansson, P., Richardson, D. (2013). Molecular Pharmacology of ABCG2 and Its Role in Chemoresistance. Molecular Pharmacology, 84(5), 655-669. [More Information]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013). P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. Journal of Biological Chemistry, 288(44), 31761-31771. [More Information]
  • Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp, D., Jansson, P., Kalinowski, D., Kovacevic, Z., Lovejoy, D., Richardson, D. (2013). The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Molecular Pharmacology, 83(1), 179-190. [More Information]
  • Kalinowski, D., Jansson, P., Kovacevic, Z., Richardson, D. (2013). The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. Redox Report, 18(2), 48-50. [More Information]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013). The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology, 66(11), 911-917. [More Information]
  • Quach, P., Gutierrez, E., Basha, M., Kalinowski, D., Sharpe, P., Lovejoy, D., Bernhardt, P., Jansson, P., Richardson, D. (2012). Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect. Molecular Pharmacology, 82(1), 105-114. [More Information]
  • Lovejoy, D., Sharp, D., Seebacher, N., Obeidy, P., Prichard, T., Stefani, C., Basha, M., Sharpe, P., Jansson, P., Kalinowski, D., Richardson, D., et al (2012). Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry, 55(16), 7230-7244. [More Information]
  • Lovejoy, D., Jansson, P., Brunk, U., Wong, J., Ponka, P., Richardson, D. (2011). Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes. Cancer Research, 71(17), 5871-5880. [More Information]
  • Stefani, C., Punnia-Moorthy, G., Lovejoy, D., Jansson, P., Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2011). Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity. Journal of Medicinal Chemistry, 54(19), 6936-6948. [More Information]
  • Jansson, P., Sharpe, P., Bernhardt, P., Richardson, D. (2010). Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity. Journal of Medicinal Chemistry, 53(15), 5759-5769. [More Information]
  • Jansson, P., Hawkins, C., Lovejoy, D., Richardson, D. (2010). The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study. Journal of Inorganic Biochemistry, 104(11), 1224-1228. [More Information]
  • Richardson, D., Kalinowski, D., Lau, S., Jansson, P., Lovejoy, D. (2009). Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochimica et Biophysica Acta, 1790 (7), 702-717. [More Information]
  • Mladenka, P., Kalinowski, D., Haskova, P., Bobrovova, Z., Hrdina, R., Simunek, T., Nachtigal, P., Semecky, V., Vavrova, J., Holeckova, M., Jansson, P., Richardson, D., et al (2009). The Novel Iron Chelator, 2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl Hydrazone, Reduces Catecholamine-Mediated Myocardial Toxicity. Chemical Research in Toxicology, 22(1), 208-217. [More Information]
  • Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas, A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe, P., Bernhardt, P., Richardson, D. (2009). Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of Medicinal Chemistry, 52(17), 5271-5294. [More Information]
  • Jansson, P., Del Castillo, U., Lindqvist, C., Nordstrom, T. (2005). Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water. Free Radical Research, 39(5), 565-570. [More Information]
  • Jansson, P., Lindqvist, C., Nordstrom, T. (2005). Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water. Free Radical Research, 39(11), 1233-1239. [More Information]
  • Jansson, P., Jung, H., Lindqvist, C., Nordstrom, T. (2004). Oxidative Decomposition of Vitamin C in Drinking Water. Free Radical Research, 38(8), 855-860. [More Information]
  • Jansson, P., Asplund, K., Makela, J., Lindqvist, C., Nordstrom, T. (2003). Vitamin C (Ascorbic Acid) Induced Hydroxyl Radical Formation in Copper Contaminated Household Drinking Water: Role of Bicarbonate Concentration. Free Radical Research, 37(8), 901-905. [More Information]

2018

  • Lane, D., Bae, D., Siafakas, A., Rahmanto, Y., Al-Akra, L., Jansson, P., Casero Jr., R., Richardson, D. (2018). Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1864 (9 Part B), 2793-2813. [More Information]
  • Park, K., Menezes, S., Kalinowski, D., Sahni, S., Jansson, P., Kovacevic, Z., Richardson, D. (2018). Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1864 (8), 2644-2663. [More Information]
  • Chiang, S., Kalinowski, D., Jansson, P., Richardson, D., Huang, M. (2018). Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia. Neurochemistry International, 117, 35-48. [More Information]
  • Palanimuthu, D., Wu, Z., Jansson, P., Braidy, N., Bernhardt, P., Richardson, D., Kalinowski, D. (2018). Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease. Dalton Transactions, 47(21), 7190-7205. [More Information]
  • Bae, D., Lane, D., Jansson, P., Richardson, D. (2018). The old and new biochemistry of polyamines. Biochimica et Biophysica Acta - General Subjects, 1862 (9), 2053-2068. [More Information]
  • Al-Akra, L., Bae, D., Sahni, S., Huang, M., Park, K., Lane, D., Jansson, P., Richardson, D. (2018). Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones. Journal of Biological Chemistry, 293(10), 3562-3587. [More Information]

2017

  • Sahni, S., Bae, D., Jansson, P., Richardson, D. (2017). The mechanistic role of chemically diverse metal ions in the induction of autophagy. Pharmacological Research, 119, 118-127. [More Information]

2016

  • Seebacher, N., Richardson, D., Jansson, P. (2016). A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC. Cell Death and Disease, 7(12), 1-13. [More Information]
  • Lok, H., Sahni, S., Jansson, P., Kovacevic, Z., Hawkins, C., Richardson, D. (2016). A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity. Journal of Biological Chemistry, 291(53), 27042-27061. [More Information]
  • Lane, D., Jansson, P., Richardson, D. (2016). Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly. Aging, 8(5), 1150-1152.
  • Park, K., Fouani, L., Jansson, P., Wooi, D., Sahni, S., Lane, D., Palanimuthu, D., Lok, H., Kovacevic, Z., Huang, M., Kalinowski, D., Richardson, D. (2016). Copper and conquer: Copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics. Metallomics, 8(9), 874-886. [More Information]
  • Seebacher, N., Lane, D., Jansson, P., Richardson, D. (2016). Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter. Journal of Biological Chemistry, 291(8), 3796-3820. [More Information]
  • Klionsky, D., Abdelmohsen, K., Akihisa, A., Abedin, M., Abeliovich, H., Acevedo-Arozena, A., Arozena, H., Adams, C., Adams, P., et al, Sue, C., Mihailidou, A., Bae, D., Gutierrez, E., Jansson, P., Lane, D., Merlot, A., Richardson, D., Sahni, S. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222. [More Information]
  • Gutierrez, E., Seebacher, N., Arzuman, L., Kovacevic, Z., Lane, D., Richardson, V., Merlot, A., Lok, H., Kalinowski, D., Sahni, S., Jansson, P., Richardson, D. (2016). Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT). Biochimica et Biophysica Acta, 1863 (7 Pt A), 1665-1681. [More Information]
  • Merlot, A., Shafie, N., Yu, Y., Richardson, V., Jansson, P., Sahni, S., Lane, D., Kovacevic, Z., Kalinowski, D., Richardson, D. (2016). Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2[alpha], IRE1[alpha], ATF6 and calmodulin kinase. Biochemical Pharmacology, 109, 27-47. [More Information]
  • Al-Eisawi, Z., Stefani, C., Jansson, P., Arvind, A., Sharpe, P., Basha, M., Iskander, G., Kumar, N., Kovacevic, Z., Lane, D., Sahni, S., Richardson, D., Kalinowski, D., et al (2016). Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3- selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. Journal of Medicinal Chemistry, 59(1), 294-312. [More Information]
  • Kalinowski, D., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G., Subramaniam, N., Trinder, D., Olynyk, J., Chua, A., Jansson, P., Sahni, S., Lane, D., Merlot, A., Kovacevic, Z., Huang, M., Richardson, D., et al (2016). Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta, 1863 (4), 727-748. [More Information]
  • Paluncic, J., Kovacevic, Z., Jansson, P., Kalinowski, D., Merlot, A., Huang, M., Lok, H., Sahni, S., Lane, D., Richardson, D. (2016). Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling. Biochimica et Biophysica Acta, 1863 (4), 770-784. [More Information]
  • Stacy, A., Palanimuthu, D., Bernhardt, P., Kalinowski, D., Jansson, P., Richardson, D. (2016). Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance. Journal of Medicinal Chemistry, 59(18), 8601-8620. [More Information]
  • Sahni, S., Kovacevic, Z., Kalinowski, D., Huang, M., Menezes, S., Krishan, S., Lane, D., Jansson, P., Richardson, D. (2016). Targeting autophagy in antitumor agent design: Furthering the 'lysosomal love' strategy. Future Medicinal Chemistry, 8(7), 727-729. [More Information]
  • Seebacher, N., Lane, D., Richardson, D., Jansson, P. (2016). Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance. Free Radical Biology and Medicine, 96, 432-445. [More Information]
  • Stacy, A., Palanimuthu, D., Bernhardt, P., Kalinowski, D., Jansson, P., Richardson, D. (2016). Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity. Journal of Medicinal Chemistry, 59(10), 4965-4984. [More Information]

2015

  • Lane, D., Merlot, A., Huang, M., Bae, D., Jansson, P., Sahni, S., Kalinowski, D., Richardson, D. (2015). Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochimica et Biophysica Acta - General Subjects, 1853 (5), 1130-1144. [More Information]
  • Jansson, P., Yamagishi, T., Arvind, A., Seebacher, N., Gutierrez, E., Stacy, A., Maleki, S., Sharp, D., Sahni, S., Richardson, D. (2015). Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-Glycoprotein (Pgp). Journal of Biological Chemistry, 290(15), 9588-9603. [More Information]
  • Seebacher, N., Richardson, D., Jansson, P. (2015). Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics. British Journal of Pharmacology, 172(10), 2557-2772. [More Information]
  • Stefani, C., Al-Eisawi, Z., Jansson, P., Kalinowski, D., Richardson, D. (2015). Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization. Journal of Inorganic Biochemistry, 152, 20-37. [More Information]
  • Krishan, S., Jansson, P., Gutierrez, E., Lane, D., Richardson, D., Sahni, S. (2015). Iron metabolism and autophagy: A poorly explored relationship that has important consequences for health and disease. Nagoya Journal of Medical Science, 77, 1-6.
  • Merlot, A., Kalinowski, D., Kovacevic, Z., Jansson, P., Lane, D., Sahni, S., Huang, M., Richardson, D. (2015). Making a case for albumin - a highly promising drug-delivery system. Future Medicinal Chemistry, 7(5), 553-556. [More Information]
  • Liu, W., Kovacevic, Z., Peng, Z., Jin, R., Wang, P., Yue, F., Zheng, M., Huang, M., Jansson, P., Richardson, V., Kalinowski, D., Lane, D., Merlot, A., Sahni, S., Richardson, D. (2015). The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets. Oncotarget, 6(34), 35522-35541. [More Information]
  • Liu, W., Yue, F., Zheng, M., Merlot, A., Bae, D., Huang, M., Lane, D., Jansson, P., Lui, G., Richardson, V., Sahni, S., Kalinowski, D., Kovacevic, Z., Richardson, D. (2015). The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget, 6(11), 8851-8874. [More Information]
  • Jansson, P., Kalinowski, D., Lane, D., Kovacevic, Z., Seebacher, N., Fouani, L., Sahni, S., Merlot, A., Richardson, D. (2015). The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones. Pharmacological Research, 100, 255-260. [More Information]

2014

  • Sahni, S., Merlot, A., Krishnan, S., Jansson, P., Richardson, D. (2014). Gene of the month: BECN1. Journal of Clinical Pathology, 67(8), 656-660. [More Information]
  • Fang, B., Kovacevic, Z., Park, K., Kalinowski, D., Jansson, P., Lane, D., Sahni, S., Richardson, D. (2014). Molecular Functions of the Iron-Regulated Metastasis Suppressor, NDRG1, and its Potential as a Molecular Target for Cancer Therapy. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1845 (1), 1-19. [More Information]
  • Gutierrez, E., Richardson, D., Jansson, P. (2014). The Anti-Cancer Agent, Dp44mT, Overcomes Pro-Survival Autophagy by Two Mechanisms: Persistent Induction of Autophagosome Synthesis and Impairment of Lysosomal Integrity. Journal of Biological Chemistry, 289(48), 33568-33589. [More Information]
  • Sahni, S., Bae, D., Lane, D., Kovacevic, Z., Kalinowski, D., Jansson, P., Richardson, D. (2014). The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells. Journal of Biological Chemistry, 289(14), 9692-9709. [More Information]

2013

  • Stefani, C., Jansson, P., Gutierrez, E., Bernhardt, P., Richardson, D., Kalinowski, D. (2013). Alkyl Substituted 2'-Benzoylpyridine Thiosemicarbazone Chelators with Potent and Selective Anti-Neoplastic Activity: Novel Ligands that Limit Methemoglobin Formation. Journal of Medicinal Chemistry, 56(1), 357-370. [More Information]
  • Ford, S., Obeidy, P., Lovejoy, D., Bedford, M., Nichols, L., Chadwick, C., Tucker, O., Lui, G., Kalinowski, D., Jansson, P., Richardson, D., et al (2013). Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. British Journal of Pharmacology, 168(6), 1316-1328. [More Information]
  • Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson, P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovacevic, Z., Richardson, D. (2013). Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis, 34(9), 1943-1954. [More Information]
  • Huang, M., Ramesh (Sivagurunathan), S., Ting, S., Jansson, P., Austin, C., Kelly, M., Semsarian, C., Zhang, D., Richardson, D. (2013). Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia: Activation of the Integrated Stress Response, eIF2a Phosphorylation, and the Induction of Downstream Targets. American Journal of Pathology, 183(3), 745-757. [More Information]
  • Stacy, A., Jansson, P., Richardson, D. (2013). Molecular Pharmacology of ABCG2 and Its Role in Chemoresistance. Molecular Pharmacology, 84(5), 655-669. [More Information]
  • Yamagishi, T., Sahni, S., Sharp, D., Arvind, A., Jansson, P., Richardson, D. (2013). P-Glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration. Journal of Biological Chemistry, 288(44), 31761-31771. [More Information]
  • Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp, D., Jansson, P., Kalinowski, D., Kovacevic, Z., Lovejoy, D., Richardson, D. (2013). The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action. Molecular Pharmacology, 83(1), 179-190. [More Information]
  • Kalinowski, D., Jansson, P., Kovacevic, Z., Richardson, D. (2013). The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. Redox Report, 18(2), 48-50. [More Information]
  • Bae, D., Jansson, P., Huang, M., Kovacevic, Z., Kalinowski, D., Lee, C., Sahni, S., Richardson, D. (2013). The role of NDRG1 in the pathology and potential treatment of human cancers. Journal of Clinical Pathology, 66(11), 911-917. [More Information]

2012

  • Quach, P., Gutierrez, E., Basha, M., Kalinowski, D., Sharpe, P., Lovejoy, D., Bernhardt, P., Jansson, P., Richardson, D. (2012). Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3- thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect. Molecular Pharmacology, 82(1), 105-114. [More Information]
  • Lovejoy, D., Sharp, D., Seebacher, N., Obeidy, P., Prichard, T., Stefani, C., Basha, M., Sharpe, P., Jansson, P., Kalinowski, D., Richardson, D., et al (2012). Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry, 55(16), 7230-7244. [More Information]

2011

  • Lovejoy, D., Jansson, P., Brunk, U., Wong, J., Ponka, P., Richardson, D. (2011). Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes. Cancer Research, 71(17), 5871-5880. [More Information]
  • Stefani, C., Punnia-Moorthy, G., Lovejoy, D., Jansson, P., Kalinowski, D., Sharpe, P., Bernhardt, P., Richardson, D. (2011). Halogenated 2'-Benzoylpyridine Thiosemicarbazone (XBpT) Chelators with Potent and Selective Anti-Neoplastic Activity: Relationship to Intracellular Redox Activity. Journal of Medicinal Chemistry, 54(19), 6936-6948. [More Information]

2010

  • Jansson, P., Sharpe, P., Bernhardt, P., Richardson, D. (2010). Novel Thiosemicarbazones of the ApT and DpT Series and Their Copper Complexes: Identification of Pronounced Redox Activity and Characterization of Their Antitumor Activity. Journal of Medicinal Chemistry, 53(15), 5759-5769. [More Information]
  • Jansson, P., Hawkins, C., Lovejoy, D., Richardson, D. (2010). The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study. Journal of Inorganic Biochemistry, 104(11), 1224-1228. [More Information]

2009

  • Richardson, D., Kalinowski, D., Lau, S., Jansson, P., Lovejoy, D. (2009). Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochimica et Biophysica Acta, 1790 (7), 702-717. [More Information]
  • Mladenka, P., Kalinowski, D., Haskova, P., Bobrovova, Z., Hrdina, R., Simunek, T., Nachtigal, P., Semecky, V., Vavrova, J., Holeckova, M., Jansson, P., Richardson, D., et al (2009). The Novel Iron Chelator, 2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl Hydrazone, Reduces Catecholamine-Mediated Myocardial Toxicity. Chemical Research in Toxicology, 22(1), 208-217. [More Information]
  • Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas, A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe, P., Bernhardt, P., Richardson, D. (2009). Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of Medicinal Chemistry, 52(17), 5271-5294. [More Information]

2005

  • Jansson, P., Del Castillo, U., Lindqvist, C., Nordstrom, T. (2005). Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water. Free Radical Research, 39(5), 565-570. [More Information]
  • Jansson, P., Lindqvist, C., Nordstrom, T. (2005). Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water. Free Radical Research, 39(11), 1233-1239. [More Information]

2004

  • Jansson, P., Jung, H., Lindqvist, C., Nordstrom, T. (2004). Oxidative Decomposition of Vitamin C in Drinking Water. Free Radical Research, 38(8), 855-860. [More Information]

2003

  • Jansson, P., Asplund, K., Makela, J., Lindqvist, C., Nordstrom, T. (2003). Vitamin C (Ascorbic Acid) Induced Hydroxyl Radical Formation in Copper Contaminated Household Drinking Water: Role of Bicarbonate Concentration. Free Radical Research, 37(8), 901-905. [More Information]

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