Dr Patrick Bertolino

NHMRC Senior Research Fellow
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6186
Fax +61 2 9565 6101

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Research interests

Patrick Bertolino is an immunologist investigating the interactions between the liver and the immune system in order to understand the tolerogenic property of this organ.

Selected grants

2014

  • Gene therapy vectors to investigate intrahepatic immunity; Bertolino P; DVC Research/Bridging Support Grant.

2013

  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Deciphering mechanisms of liver allograft tolerance; Bertolino P, Dwyer K, Bowen D, Bishop A; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Next-generation high-speed flow cytometric cell sorter; Fazekas B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inflammation, Angiogenesis and Cancer; Vadas M, McCaughan G, Gamble J, Bertolino P, Xia P; National Health and Medical Research Council (NHMRC)/Program Grants.

2009

  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Understanding the role of resident and donor leucocytes in liver and solid organ transplantation; Bertolino P; Roche Organ Transplant Research Foundation (Switzerland)/Research Support.
  • Career Awards: Research Fellowship; Bertolino P; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.

2007

  • Understanding rapid T-cell clearance by the liver: a critical step towards improved liver transplantation.; Bertolino P, Bishop A; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • FACS Aria for the University of Sydney Flow Cytometry Facility; King N, Pollard J, Rasko J, Lovicu F, Bishop A, Bertolino P, Briscoe H, Gillies M, Madigan M, McAvoy J, Murphy C, Balcar V, Armour C, Hughes M, Reeve V, Christopherson R, Halliday G, Christie M, Pollock C, McCaughan G, Gorrell M, Dong Q, Abendroth A, Menzies S, Barnetson R, Byrne S, Hunt N, Hambly B, Cook D, Mason R, Day M, Black J; University of Sydney/Equipment Grant.

2001

  • Transgenic mice: a unique model to reassess specific T cell suppression; Bertolino P; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Role of hepatocytes in inducing primary CD8+ T cell activation and tolerance; Bertolino P; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.
  • Bertolino, P., McCaughan, G., Bowen, D. (2008). Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In Emilio Jirillo (Eds.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications, (pp. 39-70). United States: Springer.
  • Bertolino, P., Bowen, D., Zen, M., McCaughan, G. (2005). Autoimmune hepatitis in transgenic mouse models: what lessons can be learnt? In H. P. Dienes, U. Leuschner, A. W. Lohse, M. P. Manns (Eds.), Autoimmune Liver Disease: Proceedings of the Falk Symposium No. 142, (pp. 60-72). The Netherlands: Springer.

Journals

  • Tay, S., Lu, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A., Cowan, P., McCaughan, G., Dwyer, K., Bowen, D., et al (2013). Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation. Liver Transplantation, 19(11), 1224-1235. [More Information]
  • Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
  • McCaughan, G., Bowen, D., Bertolino, P. (2013). Operational tolerance in liver transplantation: Shall we predict or promote? Liver Transplantation, 19(9), 933-936. [More Information]
  • Chowdhury, S., Chen, Y., Yao, T., Ajami, K., Wang, X., Popov, Y., Schuppan, D., Bertolino, P., McCaughan, G., Yu, M., Gorrell, M. (2013). Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World Journal of Gastroenterology, 19(19), 2883-2893. [More Information]
  • Holz, L., Benseler, V., Vo, M., McGuffog, C., Van Rooijen, N., McCaughan, G., Bowen, D., Bertolino, P. (2012). Naive CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2(low) Bim(high) phenotype, poor CTL function and cell death. Journal of Hepatology, 57(4), 830-836. [More Information]
  • Bishop, A., Bertolino, P., Bowen, D., McCaughan, G. (2012). Tolerance in liver transplantation. Best Practice & Research: Clinical Gastroenterology, 26(1), 73-84. [More Information]
  • Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012). Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology, 57(2), 352-358. [More Information]
  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(40), 16735-16740. [More Information]
  • Benseler, V., Tay, S., Bowen, D., Bertolino, P. (2011). Role of the Hepatic Parenchyma in Liver Transplant Tolerance: a Paradigm Revisited. Digestive Diseases, 29(4), 391-401. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
  • Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]
  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
  • Viebahn, C., Benseler, V., Holz, L., Elsegood, C., Vo, M., Bertolino, P., Ganss, R., Yeoh, G. (2010). Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury. Journal of Hepatology, 53(3), 500-507. [More Information]
  • Holz, L., Bowen, D., Bertolino, P. (2010). Mechanisms of T cell death in the liver: to Bim or not to Bim? Digestive Diseases, 28(1), 14-24. [More Information]
  • McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
  • Dahlke, M., Hoogduijn, M., Eggenhofer, E., Popp, F., Renner, P., Slowik, P., Rosenauer, A., Piso, P., Bertolino, P., Schlitt, H., et al (2009). Toward MSC in Solid Organ Transplantation: 2008 Position Paper of the MISOT Study Group. Transplantation, 88, 614-619. [More Information]
  • Allen, K., Mifsud, N., Williamson, R., Bertolino, P., Hardikar, W. (2008). Cell-mediated rejection results in allograft loss after liver cell transplantation. Liver Transplantation, 14(5), 688-694. [More Information]
  • Bertolino, P. (2008). Impaired function of dendritic cells translocating the liver sinusoids: a veto effect contributing to intrahepatic tolerance? European Journal of Immunology, 38(4), 938-941. [More Information]
  • Bertolino, P. (2008). Interleukin-22, interleukin-17, and other cytokines: a wall is coming down. Hepatology, 47(1), 345-348. [More Information]
  • Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., D'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008). Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology, 135(3), 989-997. [More Information]
  • Holz, L., McCaughan, G., Benseler, V., Bertolino, P., Bowen, D. (2008). Liver tolerance and the manipulation of immune outcomes. Inflammation and Allergy: Drug Targets, 7(1), 6-18. [More Information]
  • Bertolino, P., Bowen, D., Benseler, V. (2007). T cells in the liver: there is life beyond the graveyard. Hepatology, 45(6), 1580-1582. [More Information]
  • Benseler, V., McCaughan, G., Schlitt, H., Bishop, A., Bowen, D., Bertolino, P. (2007). The liver: a special case in transplantation tolerance. Seminars in Liver Disease, 27(2), 194-213. [More Information]
  • Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]
  • Bertolino, P., Holz, L. (2007). Toll-like receptor-3 and the regulation of intrahepatic immunity: implications for interferon-alpha therapy. Hepatology (Baltimore Md.), 45(1), 250-251. [More Information]
  • Wang, C., Cordoba, S., Bertolino, P., Alexander, S., Wu, M., Allen, R., McCaughan, G., Bishop, A. (2006). Examination of the immune mechanism of spontaneous tolerance of renal allografts in a mouse model. Immunology and Cell Biology, 84(1), A29-30.
  • Dahlke, M., Loi, R., Warren, A., Holz, L., Popp, F., Weiss, D., Piso, P., Bowen, D., McCaughan, G., Schlitt, H., Bertolino, P. (2006). Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology, 44(2), 334-341. [More Information]
  • Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
  • Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]
  • Bertolino, P., Schrage, A., Bowen, D., Klugewitz, K., Ghani, S., Eulenburg, K., Holz, L., Hogg, N., McCaughan, G., Hamann, A. (2005). Early intrahepatic antigen-specific retention of naïve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology, 42(5), 1063-1071. [More Information]
  • Cordoba, S., Wang, C., Li, J., Bertolino, P., McCaughan, G., Bishop, A. (2005). Examination of immune mechanisms in a mouse model of spontaneous renal allograft acceptance. Immunology and Cell Biology, 83(4 Supplement), A20-A21.
  • Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
  • Bowen, D., McCaughan, G., Bertolino, P. (2005). Intrahepatic immunity: a tale of two sites? Trends in Immunology, 26(10), 512-517. [More Information]
  • Sun, J., Tumurbaatar, B., Jia, J., Diao, H., Bodola, F., Lemon, S., Tang, W., Bowen, D., McCaughan, G., Bertolino, P., et al (2005). Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury. Journal of Virology, 79(16), 10730-10739. [More Information]
  • Holz, L., Benseler, V., Gengos, M., Newtown, R., McCaughan, G., Bertolino, P. (2005). Phenotype of CD8+ T cells activated in the liver. Tissue Antigens: immune response genetics, 66(5), 444 (Abstract 279)-444.
  • Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.
  • McCaughan, G., Bertolino, P., Bowen, D., Zen, M., Holz, L., Davis, T. (2004). The Site Of Primary T Cell Activation Is A Determinant Of The Balance Between Intrahepatic Tolerance And Immunity. Journal of Clinical Investigation, 114(5), 701-712.
  • Demangel, C., Bertolino, P., Britton, W. (2002). Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. European Journal of Immunology, 32(4), 994-1002.
  • Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264.
  • Greenhalgh, C., Bertolino, P., Asa, S., Metcalf, D., Corbin, J., Adams, T., Davey, H., Nicola, N., Hilton, D., Alexander, W. (2002). Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Molecular Endocrinology, 16(6), 1394-1406.
  • Bertolino, P., McCaughan, G., Bowen, D. (2002). Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'. Immunology and Cell Biology, 80(1), 84-92.
  • Bertolino, P., Bowen, D., McCaughan, G., Fazekas, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.

Conferences

  • Benseler, V., Holz, L., Schlitt, H., Brinkmann, V., McCaughan, G., Bertolino, P. (2006). FTY720 treatment leads to sequestration but not accumulation of antigen-specific CD8+ T cells activated in lymph nodes.

2013

  • Tay, S., Lu, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A., Cowan, P., McCaughan, G., Dwyer, K., Bowen, D., et al (2013). Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation. Liver Transplantation, 19(11), 1224-1235. [More Information]
  • Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
  • McCaughan, G., Bowen, D., Bertolino, P. (2013). Operational tolerance in liver transplantation: Shall we predict or promote? Liver Transplantation, 19(9), 933-936. [More Information]
  • Chowdhury, S., Chen, Y., Yao, T., Ajami, K., Wang, X., Popov, Y., Schuppan, D., Bertolino, P., McCaughan, G., Yu, M., Gorrell, M. (2013). Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World Journal of Gastroenterology, 19(19), 2883-2893. [More Information]

2012

  • Holz, L., Benseler, V., Vo, M., McGuffog, C., Van Rooijen, N., McCaughan, G., Bowen, D., Bertolino, P. (2012). Naive CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2(low) Bim(high) phenotype, poor CTL function and cell death. Journal of Hepatology, 57(4), 830-836. [More Information]
  • Bishop, A., Bertolino, P., Bowen, D., McCaughan, G. (2012). Tolerance in liver transplantation. Best Practice & Research: Clinical Gastroenterology, 26(1), 73-84. [More Information]
  • Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012). Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology, 57(2), 352-358. [More Information]

2011

  • Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 108(40), 16735-16740. [More Information]
  • Benseler, V., Tay, S., Bowen, D., Bertolino, P. (2011). Role of the Hepatic Parenchyma in Liver Transplant Tolerance: a Paradigm Revisited. Digestive Diseases, 29(4), 391-401. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
  • Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]

2010

  • Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
  • Viebahn, C., Benseler, V., Holz, L., Elsegood, C., Vo, M., Bertolino, P., Ganss, R., Yeoh, G. (2010). Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury. Journal of Hepatology, 53(3), 500-507. [More Information]
  • Holz, L., Bowen, D., Bertolino, P. (2010). Mechanisms of T cell death in the liver: to Bim or not to Bim? Digestive Diseases, 28(1), 14-24. [More Information]

2009

  • McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
  • Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.
  • Dahlke, M., Hoogduijn, M., Eggenhofer, E., Popp, F., Renner, P., Slowik, P., Rosenauer, A., Piso, P., Bertolino, P., Schlitt, H., et al (2009). Toward MSC in Solid Organ Transplantation: 2008 Position Paper of the MISOT Study Group. Transplantation, 88, 614-619. [More Information]

2008

  • Allen, K., Mifsud, N., Williamson, R., Bertolino, P., Hardikar, W. (2008). Cell-mediated rejection results in allograft loss after liver cell transplantation. Liver Transplantation, 14(5), 688-694. [More Information]
  • Bertolino, P., McCaughan, G., Bowen, D. (2008). Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In Emilio Jirillo (Eds.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications, (pp. 39-70). United States: Springer.
  • Bertolino, P. (2008). Impaired function of dendritic cells translocating the liver sinusoids: a veto effect contributing to intrahepatic tolerance? European Journal of Immunology, 38(4), 938-941. [More Information]
  • Bertolino, P. (2008). Interleukin-22, interleukin-17, and other cytokines: a wall is coming down. Hepatology, 47(1), 345-348. [More Information]
  • Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., D'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008). Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology, 135(3), 989-997. [More Information]
  • Holz, L., McCaughan, G., Benseler, V., Bertolino, P., Bowen, D. (2008). Liver tolerance and the manipulation of immune outcomes. Inflammation and Allergy: Drug Targets, 7(1), 6-18. [More Information]

2007

  • Bertolino, P., Bowen, D., Benseler, V. (2007). T cells in the liver: there is life beyond the graveyard. Hepatology, 45(6), 1580-1582. [More Information]
  • Benseler, V., McCaughan, G., Schlitt, H., Bishop, A., Bowen, D., Bertolino, P. (2007). The liver: a special case in transplantation tolerance. Seminars in Liver Disease, 27(2), 194-213. [More Information]
  • Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]
  • Bertolino, P., Holz, L. (2007). Toll-like receptor-3 and the regulation of intrahepatic immunity: implications for interferon-alpha therapy. Hepatology (Baltimore Md.), 45(1), 250-251. [More Information]

2006

  • Wang, C., Cordoba, S., Bertolino, P., Alexander, S., Wu, M., Allen, R., McCaughan, G., Bishop, A. (2006). Examination of the immune mechanism of spontaneous tolerance of renal allografts in a mouse model. Immunology and Cell Biology, 84(1), A29-30.
  • Benseler, V., Holz, L., Schlitt, H., Brinkmann, V., McCaughan, G., Bertolino, P. (2006). FTY720 treatment leads to sequestration but not accumulation of antigen-specific CD8+ T cells activated in lymph nodes.
  • Dahlke, M., Loi, R., Warren, A., Holz, L., Popp, F., Weiss, D., Piso, P., Bowen, D., McCaughan, G., Schlitt, H., Bertolino, P. (2006). Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology, 44(2), 334-341. [More Information]
  • Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
  • Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]

2005

  • Bertolino, P., Bowen, D., Zen, M., McCaughan, G. (2005). Autoimmune hepatitis in transgenic mouse models: what lessons can be learnt? In H. P. Dienes, U. Leuschner, A. W. Lohse, M. P. Manns (Eds.), Autoimmune Liver Disease: Proceedings of the Falk Symposium No. 142, (pp. 60-72). The Netherlands: Springer.
  • Bertolino, P., Schrage, A., Bowen, D., Klugewitz, K., Ghani, S., Eulenburg, K., Holz, L., Hogg, N., McCaughan, G., Hamann, A. (2005). Early intrahepatic antigen-specific retention of naïve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology, 42(5), 1063-1071. [More Information]
  • Cordoba, S., Wang, C., Li, J., Bertolino, P., McCaughan, G., Bishop, A. (2005). Examination of immune mechanisms in a mouse model of spontaneous renal allograft acceptance. Immunology and Cell Biology, 83(4 Supplement), A20-A21.
  • Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
  • Bowen, D., McCaughan, G., Bertolino, P. (2005). Intrahepatic immunity: a tale of two sites? Trends in Immunology, 26(10), 512-517. [More Information]
  • Sun, J., Tumurbaatar, B., Jia, J., Diao, H., Bodola, F., Lemon, S., Tang, W., Bowen, D., McCaughan, G., Bertolino, P., et al (2005). Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury. Journal of Virology, 79(16), 10730-10739. [More Information]
  • Holz, L., Benseler, V., Gengos, M., Newtown, R., McCaughan, G., Bertolino, P. (2005). Phenotype of CD8+ T cells activated in the liver. Tissue Antigens: immune response genetics, 66(5), 444 (Abstract 279)-444.
  • Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.

2004

  • McCaughan, G., Bertolino, P., Bowen, D., Zen, M., Holz, L., Davis, T. (2004). The Site Of Primary T Cell Activation Is A Determinant Of The Balance Between Intrahepatic Tolerance And Immunity. Journal of Clinical Investigation, 114(5), 701-712.

2002

  • Demangel, C., Bertolino, P., Britton, W. (2002). Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. European Journal of Immunology, 32(4), 994-1002.
  • Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264.
  • Greenhalgh, C., Bertolino, P., Asa, S., Metcalf, D., Corbin, J., Adams, T., Davey, H., Nicola, N., Hilton, D., Alexander, W. (2002). Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Molecular Endocrinology, 16(6), 1394-1406.
  • Bertolino, P., McCaughan, G., Bowen, D. (2002). Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'. Immunology and Cell Biology, 80(1), 84-92.

2001

  • Bertolino, P., Bowen, D., McCaughan, G., Fazekas, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.

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