Professor Patrick Tam

Professor & NHMRC Senior Principal Research Fellow
Medicine, Children's Medical Research Institute

Telephone +61 2 96872800
Fax 96872120

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Research interests

Dr Tam is internationally recognized for pioneering the application of micromanipulation and embryo culture for analyzing the development of mouse embryos and fate mapping of the mouse germ layers and embryonic gut.

His research focuses on the cellular and molecular mechanisms of body patterning during mouse development. His research includes pioneering the application of micromanipulation and embryo culture for analysing mouse embryos and examining the development of the neural tube and embryonic gut. His other current research is on X-linked diseases.

Selected grants

2014

  • Aberrant mesenchymal-epithelial transition: a pathogenic mechanism in tissue maintenance and differentiation; Tam P, Loebel D, Graham M, Arthur J; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Fluidigm BioMark HD - HX; Alexander I, Jamieson R, Chircop (nee Fabbro) M, Byrne J, Catchpoole D, Reddel R, Tam P, Robinson P, Bryan T, Diefenbach R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Molecular function of the RNA binding protein, RBM47, in embryonic and mature endoderm cells; Tam P, Arthur J; Australian Research Council (ARC)/Discovery Projects (DP).

2012

  • A molecular paradigm of organ formation during embryonic development: The role of RhoGTPase; Tam P, Loebel D; Australian Research Council (ARC)/Discovery Projects (DP).
  • Cellular therapy for genetic liver disease exploiting induced pluripotent stem cells and liver progenitor cells; Alexander I, Tam P, Russell D, Yeoh G; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • The BD Influx High Speed Cell Sorter; Kefford R, Cunningham A, Bendall L, Clarke C, Harris D, Alexander S, Tam P, Sorrell T, Iredell J, Bryan T, Rizos H, Wang Y, Hebbard L; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Multipotent stem cells derived from postimplantation mouse embryos: Evaluation of germ layer differentiation potential; Tam P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Genetic control of body patterning: Intersection of transciptional and signalling activity in head formation; Tam P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Head and Face Development: Dissecting the gene functions specific to the precursors; Tam P; Australian Research Council (ARC)/Discovery Projects (DP).

2009

  • Molecular control of embryonic patterning: The function of Rhou gene in mediating response to WNT signalling; Tam P, Robb L; Australian Research Council (ARC)/Discovery Projects (DP).
  • Deltavision (DV) Core Image Restoration; Cunningham A, Turville S, Clarke C, Henderson B, Kefford R, North K, O'Neill G, Murray R, Reddel R, Tam P, Robinson P, Chircop M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Identification and Characterisation of Novel Cyclin-Dependent Kinase-like 5 Targets: Implications for Rett Syndrome and Related Neurodevelopmental Disorders; Christodoulou J, Tam P; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Functional Significance of MeCP2 Target Genes in the Pathogenesis of Rett Syndrome; Christodoulou J, Tam P, El-Osta A; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Edited Books

  • Tam, P., Nelson, W., Rossant, J. (2013). Mammalian Development: Networks, Switches, and Morphogenetic Processes. New York: Cold Spring Harbor Laboratory Press.
  • Tam, P., Rossant, J. (2002). Mouse Development: Patterning, Morphogenesis and Organogensis. San Francisco United States: Academic Press Elsevier.

Book Chapters

  • Tanaka, S., Yamaguchi, Y., Jones, V., Tam, P. (2014). Analyzing gene function in whole mouse embryo and fetal organ in vitro. (pp. 367-393). [More Information]
  • Loebel, D., Radziewic, T., Power, M., Studdert, J., Tam, P. (2014). Generation of mouse embryos with small hairpin RNA-mediated knockdown of gene expression. In Mark Lewandoski (Eds.), Mouse Molecular Embryology: Methods in Molecular Biology, (pp. 119-142). United States: Humana Press. [More Information]
  • Stephenson, R., Rossant, J., Tam, P. (2013). Reprint: Intercellular Interactions, Position, and Polarity in Establishing Blastocyst Cell Lineages. In Patrick P. L. Tam, W. James Nelson, Janet Rossant (Eds.), Mammalian Development: Networks, Switches, and Morphogenetic Processes, (pp. 167-182). New York: Cold Spring Harbor Laboratory Press.
  • Fossat, N., Loebel, D., Jones, V., Khoo, P., Bildsoe, H., Tam, P. (2011). Marking Cells for Imaging Analysis of Morphogenetic Behavior and Cell Fates in Mouse Embryos. In James Sharpe, Rachel Wong (Eds.), Imaging in Developmental Biology: A Laboratory Manual, (pp. 311-329). Woodbury, New York, USA: Cold Spring Harbor Laboratory Press.
  • Rivera-Perez, J., Jones, V., Tam, P. (2010). Culture of Whole Mouse Embryos at Early Postimplantation to Organogenesis Stages: Developmental Staging and Methods. In Paul M. Wassarman & Philippe M. Soriano (Eds.), Methods in Enzymology Volume 476: Guide to Techniques in Mouse Development, Part A: Mice, Embryos, and Cells, (pp. 185-203). United States: Elsevier.
  • Tam, P., Gossler, A. (2002). Somitogenesis: Segmentation of the Paraxial Mesodeerm and the delineation of tissue compartments. In Janet Rossant & Patrick L. Tam (Eds.), Mouse Development, (pp. 127-149). San Francisco: Staempfli Publishers Ltd.

Journals

  • Gold, W., Williamson, S., Kaur, S., Hargreaves, I., Land, J., Pelka, G., Tam, P., Christodoulou, J. (2014). Mitochondrial dysfunction in the skeletal muscle of a mouse model of Rett syndrome (RTT): Implications for the disease phenotype. Mitochondrion, 15, 10-17. [More Information]
  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Devleopment, 27(1), 18-23. [More Information]
  • Maxwell, S., Pelka, G., Tam, P., El-Osta, A. (2013). Chromatin context and ncRNA highlight targets of MeCP2 in brain. RNA Biology, 10(11), 1741-1757. [More Information]
  • Tanaka, S., Nakane, A., Yamaguchi, Y., Terabayashi, T., Abe, T., Nakao, K., Asashima, M., Steiner, K., Tam, P., Nishinakamura, R. (2013). Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo. PLoS One, 8(3), 1-14. [More Information]
  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
  • Tam, P., Pera, M. (2013). Stem cell science and regenerative medicine. BioEssays : news and reviews in molecular cellular and developmental biology, 35(3), 147-148. [More Information]
  • Bildsoe, H., Loebel, D., Jones, V., Hor, A., Braithwaite, A., Chen, Y., Behringer, R., Tam, P. (2013). The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss fof Twist1 function. Developmental Biology, 374(2), 295-307. [More Information]
  • Ng, H., Tam, P. (2013). The mystique of cellular reprogramming. Current Opinion in Genetics & Development, 23(5), 501-503. [More Information]
  • Arkell, R., Fossat, N., Tam, P. (2013). Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output. Current Opinion in Genetics & Development, 23(4), 454-460. [More Information]
  • Williamson, S., Giudici, L., Kilstrup-Nielsen, C., Gold, W., Pelka, G., Tam, P., Grimm, A., Prodi, D., Landsberger, N., Christodoulou, J. (2012). A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain. Human Genetics, 131(2), 187-200. [More Information]
  • Arkell, R., Tam, P. (2012). Initiating head development in mouse embryos: integrating signalling and transcriptional activity. Open Biology, 2(March 2012), 1-10. [More Information]
  • Stephenson, R., Rossant, J., Tam, P. (2012). Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. Cold Spring Harbor Perspectives in Biology, 4(11), 1-15. [More Information]
  • Fossat, N., Jones, V., Garcia-Garcia, M., Tam, P. (2012). Modulation of WNT signaling activity is key to the formation of the embryonic head. Cell Cycle, 11(1), 26-32. [More Information]
  • Loebel, D., Hor, A., Bildsoe, H., Jones, V., Chen, Y., Behringer, R., Tam, P. (2012). Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton. Developmental Biology, 362(2), 132-140. [More Information]
  • Loebel, D., Tam, P. (2012). Rho GTPases in endoderm development and differentiation. Small GTPases, 3(1), 40-44. [More Information]
  • Coombes, A., Bowles, J., Feng, C., Chiu, H., Khoo, P., Jackson, A., Little, M., Tam, P., Koopman, P. (2011). Expression and functional analysis of Dkk1 during early gonadal development. Sexual Development, 5(3), 124-130. [More Information]
  • Tanaka, S., Kojima, Y., Yamaguchi, Y., Nishinakamura, R., Tam, P. (2011). Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo. Development, Growth and Differentiation, 53(7), 843-856. [More Information]
  • Loebel, D., Studdert, J., Power, M., Radziewic, T., Jones, V., Coultas, L., Jackson, Y., Rao, R., Steiner, K., Fossat, N., Tam, P., et al (2011). Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development (Cambridge), 138(20), 4511-4522. [More Information]
  • Pfister, S., Jones, V., Power, M., Truisi, G., Khoo, P., Steiner, K., Kanai-Azuma, M., Kanai, Y., Tam, P., Loebel, D. (2011). Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. International Journal of Developmental Biology. [More Information]
  • Fossat, N., Jones, V., Khoo, P., Bogani, D., Hardy, A., Steiner, K., Mukhopadhyay, M., Westphal, H., Nolan, P., Arkell, R., Tam, P. (2011). Stringent Requirement of a Proper Level of Canonical WNT Signalling Activity for Head Formation in Mouse Embryo. Development (Cambridge), 138(4), 667-676. [More Information]
  • Harikrishnan, K., Bayles, R., Ciccotosto, G., Maxwell, S., Cappai, R., Pelka, G., Tam, P., Christodoulou, J., El-Osta, A. (2010). Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons. The Journal of Neuroscience, 30(4), 1494-1501. [More Information]
  • Pera, M., Tam, P. (2010). Extrinsic regulation of pluripotent stem cells. Nature, 465(7299), 713-720. [More Information]
  • Tanaka, S., Yamaguchi, Y., Steiner, K., Nakano, T., Nishinakamura, R., Kwan, K., Behringer, R., Tam, P. (2010). Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse. Developmental Dynamics, 239(11), 2851-2859. [More Information]
  • Leung, A., Wong, S., Chan, D., Tam, P., Cheah, K. (2010). Loss of Procollagen IIA From the Anterior Mesendoderm Disrupts the Development of Mouse Embryonic Forebrain. Developmental Dynamics, 239(9), 2319-2329. [More Information]
  • Fath, T., Chan, Y., Vrhovski, B., Clarke, H., Curthoys, N., Hook, J., Lemckert, F., Schevzov, G., Tam, P., Watson, C., Gunning, P., et al (2010). New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2. European Journal of Cell Biology, 89(7), 489-498. [More Information]
  • Weaving, L., Mihelec, M., Storen, R., Sosic, D., Grigg, J., Tam, P., Jamieson, R. (2010). Twist2: Role in Corneal Stromal Keratocyte Proliferation and Corneal Thickness. Investigative Ophthalmology and Visual Science, 51(11), 5561-5570. [More Information]
  • Rossant, J., Tam, P. (2009). Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development (Cambridge), 136(5), 701-713. [More Information]
  • Mihelec, M., Abraham, P., Gibson, K., Krowka, R., Susman, R., Storen, R., Chen, Y., Donald, J., Tam, P., Flaherty, M., Grigg, J., Jamieson, R., et al (2009). Novel SOX2 partner-factor domain mutation in a four-generation family. European Journal of Human Genetics, 17(11), 1417-1422. [More Information]
  • Bildsoe, H., Loebel, D., Jones, V., Chen, Y., Behringer, R., Tam, P. (2009). Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Developmental Biology, 331(2), 176-188. [More Information]
  • Tam, P., Loebel, D. (2009). Specifying mouse embryonic germ cells. Cell, 137(3), 398-400. [More Information]
  • Grassinger, J., Haylock, D., Storan, M., Haines, G., Williams, B., Whitty, G., Vinson, A., Be, C., Li, S., Tam, P. (2009). Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with α9β1 and α4β1 integrins. Blood, 114(1), 49-59. [More Information]
  • Watson, C., Trainor, P., Radziewic, T., Pelka, G., Zong, Z., Parameswaran, M., Quinlan, G., Gordon, M., Sturm, K., Tam, P., et al (2008). Application of lacZ Transgenic Mice to Cell Lineage Studies. Methods in Molecular Biology, 461, 149-164. [More Information]
  • Furtado, M., Solloway, M., Jones, V., Costa, M., Biben, C., Wolstein, O., Preis, J., Sparrow, D., Saga, Y., Dunwoodie, S., et al (2008). BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes and Development, 22, 3037-3049. [More Information]
  • Quinlan, G., Khoo, P., Wong, N., Trainor, P., Tam, P. (2008). Cell grafting and labeling in postimplantation mouse embryos. Methods in Molecular Biology, 461, 47-70. [More Information]
  • Mihelec, M., St Heaps, L., Flaherty, M., Billson, F., Rudduck, C., Tam, P., Grigg, J., Peters, G., Jamieson, R. (2008). Chromosomal Rearrangements and Novel Genes in Disorders of Eye Development, Cataract and Glaucoma. Twin Research and Human Genetics, 11(4), 412-421. [More Information]
  • Lewis, S., Khoo, P., Young, A., Steiner, K., Willcock, C., Mukhopadhyay, M., Westphal, H., Jamieson, R., Robb, L., Tam, P. (2008). Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development (Cambridge), 135(10), 1791-1801. [More Information]
  • Kondo, M., Gray, L., Pelka, G., Christodoulou, J., Tam, P., Hannan, A. (2008). Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome - Mecp2 gene dosage effects and BDNF expression. European Journal of Neuroscience, 27(12), 3342-3350. [More Information]
  • Franklin, V., Khoo, P., Bildsoe, H., Wong, N., Lewis, S., Tam, P. (2008). Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo. Mechanisms of Development, 125(7), 587-600. [More Information]
  • Fossat, N., Pfister, S., Tam, P. (2007). A transcriptome landscape of mouse embryogenesis. Developmental Cell, 13(6), 761-762. [More Information]
  • Tam, P., Lovell-Badge, R. (2007). Anne McLaren 1927-2007. Cell, 130(2), 201-213. [More Information]
  • Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al (2007). Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More Information]
  • Franklin, V., Bildsoe, H., Tam, P. (2007). Fate-Mapping Technique: Grafting Fluorescent Cells into Gastrula-Stage Mouse Embryos at 7-7.5 Days Post-coitum. CSH protocols, 2007, 4892. [More Information]
  • Khoo, P., Franklin, V., Tam, P. (2007). Fate-Mapping Technique: Targeted Whole-Embryo Electroporation of DNA Constructs into the Germ Layers of Mouse Embryos 7-7.5 Days Post-coitum. CSH protocols, 2007, 4893. [More Information]
  • Bildsoe, H., Franklin, V., Tam, P. (2007). Fate-mapping technique: using carbocyanine dyes for vital labeling of cells in gastrula-stage mouse embryos cultured in vitro. CSH protocols, 2007, 4915. [More Information]
  • Pfister, S., Steiner, K., Tam, P. (2007). Gene expression pattern and progression of embryogenesis in the immediate post-implantation period of mouse development. Gene Expression Patterns, 7(5), 558-573. [More Information]
  • Tam, P., Loebel, D. (2007). Gene function in mouse embryogenesis: get set for gastrulation. Nature Reviews Genetics, 8(5), 368-381. [More Information]
  • Lewis, S., Khoo, P., De Young, R., Bildsoe, H., Wakamiya, M., Behringer, R., Mukhopadhyay, M., Westphal, H., Tam, P. (2007). Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mechanisms of Development, 124(2), 157-165. [More Information]
  • Tam, P., Khoo, P., Lewis, S., Bildsoe, H., Wong, N., Tsang, T., Gad, J., Robb, L. (2007). Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development (Cambridge), 134(2), 251-260. [More Information]
  • Tam, P., Loebel, D., Tanaka, S. (2006). Building the mouse gastrula: signals, asymmetry and lineages. Current Opinion In Genetics and Development, 16(4), 419-425. [More Information]
  • Willcock, C., Grigg, J., Wilson, M., Tam, P., Billson, F., Jamieson, R. (2006). Congenital iris ectropion as an indicator of variant aniridia. The British Journal of Ophthalmology, 90(5), 658-659.
  • Lewis, S., Tam, P. (2006). Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function. Developmental Dynamics, 235(9), 2315-2329. [More Information]
  • Nolen, L., Amor, D., Haywood, A., St. Heaps, L., Willcock, C., Mihelec, M., Tam, P., Billson, F., Grigg, J., Peters, G., Jamieson, R. (2006). Deletion at 14q22-23 indicates a contiguous gene syndrome comprising anophthalmia, pituitary hypoplasia, and ear anomalies. American Journal of Medical Genetics. Part A, 140(16), 1711-1718. [More Information]
  • Duffy, S., Steiner, K., Tam, P., Boyd, A. (2006). Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development. Gene Expression Patterns, 6(7), 719-723. [More Information]
  • Yamaguchi, Y., Tanaka, S., Kasa, M., Yasuda, K., Tam, P., Matsui, Y. (2006). Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells. Gene Expression Patterns, 6(6), 607-612. [More Information]
  • Pelka, G., Watson, C., Radziewic, T., Hayward, M., Lahooti, H., Christodoulou, J., Tam, P. (2006). Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain, 129(Pt 4), 887-898. [More Information]
  • Yamaguchi, Y., Tanaka, S., Yasuda, K., Matsui, Y., Tam, P. (2006). Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Developmental Biology, 297(2), 350-360. [More Information]
  • Loebel, D., Tsoi, B., Wong, N., Tam, P. (2005). A conserved noncoding intronic transcript at the mouse Dnm3 locus. Genomics. [More Information]
  • Loebel, D., Tam, P. (2005). A gut feeling. Nature Biotechnology, 23(12), 1491-1492. [More Information]
  • Pelka, G., Watson, C., Christodoulou, J., Tam, P. (2005). Distinct expression profiles of Mecp2 transcripts with different lengths of 3'UTR in the brain and visceral organs during mouse development. Genomics, 85(4), 441-452. [More Information]
  • Tanaka, S., Yamaguchi, Y., Tsoi, B., Lickert, H., Tam, P. (2005). IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Developmental Cell, 9(6), 745-756. [More Information]
  • Watson, C., Pelka, G., Radziewic, T., Shahbazian, M., Christodoulou, J., Williamson, S., Tam, P. (2005). Reduced proportion of Purkinje cells expressing paternally derived mutant Mecp2 308 allele in female mouse cerebellum is not due to a skewed primary pattern of X-chromosome inactivation. Human Molecular Genetics, 14(13), 1851-1861. [More Information]
  • Ding, H., Wu, X., Bostrom, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G., Soriano, P., Betsholtz, C., Tam, P., et al (2004). A Specific Requirement For PDGF-C In Palate Formation And PDGFR-Alpha Signaling. Nature Genetics, 36(10), 1111-1116.
  • Tam, P. (2004). Embryonic Axes: The Long And Short Of It In The Mouse. Current Biology, 14(6), R239-R241. [More Information]
  • Rossant, J., Tam, P. (2004). Emerging Asymmetry And Embryonic Patterning In Early Mouse Development. Developmental Cell, 7(2), 155-164. [More Information]
  • Robb, L., Tam, P. (2004). Gastrula Organiser And Embryonic Patterning In The Mouse. Seminars in Cell and Developmental Biology, 15(5), 543-554.
  • Weaving, L., Christodoulou, J., Williamson, S., Friend, K., McKenzie, O., Archer, H., Evans, J., Clarke, A., Pelka, G., Tam, P., Lahooti, H., Ellaway, C., Bennetts, B., Watson, C., et al (2004). Mutations Of Cdkl5 Cause A Severe Neurodevelopmental Disorder With Infantile Spasms And Mental Retardation. American Journal of Human Genetics, 75, 1079-1093.
  • Tam, P., Khoo, P., Wong, N., Tsang, T., Behringer, R. (2004). Regionalization Of Cell Fates And Cell Movement In The Endoderm Of The Mouse Gastrula And The Impact Of Loss Of Lhx1(Lim1) Function. Developmental Biology, 274(1), 171-187.
  • Tanaka, S., Nagamatsu, G., Tokitake, Y., Kasa, M., Tam, P., Matsui, Y. (2004). Regulation Of Expression Of Mouse Interferon-Induced Transmembrane Protein Like Gene-3, Ifitm3 (Mil-1, Fragilis), In Germ Cells. Developmental Dynamics, 230(4), 651-659. [More Information]
  • Ding, H., Schertzer, M., Wu, X., Gertsenstein, M., Selig, S., Kammori, M., Pourvali, R., Poon, S., Vulto, I., et, A., Tam, P. (2004). Regulation Of Murine Telomere Length By Rtel: An Essential Gene Encoding A Helicase-Like Protein. Cell, 117(7), 873-886. [More Information]
  • Loebel, D., Tsoi, B., Wong, N., O'Rourke, M., Tam, P. (2004). Restricted Expression Of Etn-Related Sequences During Post-Implantation Mouse Development. Gene Expression Patterns, 4(4), 467-471.
  • Hukriede, N., Tsang, T., Habas, R., Khoo, P., Steiner, K., Weeks, D., Tam, P., Dawid, I. (2003). Conserved requirement of Lim1 function for cell movements during gastrulation. Developmental Cell, 4(1), 83-94.
  • Tam, P., Kanai-Azuma, M., Kanai, Y. (2003). Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Current Opinion In Genetics and Development, 13(4), 393-400.
  • Loebel, D., Watson, C., De Young, R., Tam, P. (2003). Lineage choice and differentiation in mouse embryos and embryonic stem cells. Developmental Biology, 264(1), 1-14.
  • Tam, P., Rossant, J. (2003). Mouse embryonic chimeras: tools for studying mammalian development. Development (Cambridge), 130, 6155-6163.
  • Stone, L., Tan, S., Tam, P., Finger, T. (2002). Analysis of Cell Lineage Relationships in Taste Buds. The Journal of Neuroscience, 22(11), 4522-4529.
  • Kanai-Azuma, M., Kanai, Y., Gad, J., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P., et al (2002). Depletion of definitive gut endoderm in Sox17-null mutant mice. Development (Cambridge), 129(10), 2367-2379.
  • Ristevski, S., Tam, P., Hertzog, P., Kola, I. (2002). Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo. Mechanisms of Development, 116, 165-168.
  • Tam, P. (2002). First mitotic division: getting it right at the start. Nature Cell Biology, 4(10), E232-E232.
  • Loebel, D., Orourke, M., Steiner, K., Banyer, J., Tam, P. (2002). Isolation of Differentially Expressed Genes from Wild-Type and Twist Mutant Mouse Limb Buds. Genesis, 33(3), 103-113. [More Information]
  • Hart, A., Hartley, L., Sourris, K., Stadler, E., Li, R., Stanley, E., Tam, P., Elefanty, A., Robb, L. (2002). Mixl1 is required for axial mesendoderm morpogenesis and patterning in the murine embryo. Development (Cambridge), 129(15), 3597-3608.
  • Soo, K., Orourke, M., Khoo, P., Steiner, K., Wong, N., Behringer, R., Tam, P. (2002). Twist Function is Required for morphogenesis of the Cephalic Neural Tuve and the Differentiation of the Cranial Neura Crest Cells in the Mouse Embryo. Developmental Biology, 247(2), 251-270. [More Information]
  • Orourke, M., Tam, P. (2002). Twist Functions in mouse development. International Journal of Developmental Biology, 46(4), 401-413.
  • Orourke, M., Soo, K., Behringer, R., Hui, C., Tam, P. (2002). Twist plays an essential role in FGF and SHH Signal Transduction during Mouse Limb Development. Developmental Biology, 248(1), 143-156. [More Information]
  • Kinder, S., Tam, P., Loebel, D. (2001). Allocation and Early Differentiation of Cardiovascular Progenitors in the Mouse Embryo. Trends In Cardiovascular Medicine, 11, 177-183.
  • Tam, P., Hadjantonakis, A., Cox,, L., Nagy,, A. (2001). An X-linked GFP transgene reveals unexpected paternal X-Chromosome activity in trophoblastic Giant Cells of the Mouse Placenta. Genesis, 29, 133-140.
  • Tam, P., Watson,, C. (2001). Cell Lineage Determination in the Mouse. Cell Structure and Function, 26, 123-129.
  • Kinder, S., Tsang, T., Tam, P., Ang,, S., Behringer, R. (2001). Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3B activity. International Journal of Developmental Biology, 45, 347-355.
  • Tam, P., Ristevski, S., Kola,, I., Hertzog, P. (2001). Desrt, an AT-rich interaction domain family transcription factor gene, is an early marker for nephrogenic mesoderm and is expressed dynamically during mourse limb development. Mechanisms of Development, 104, 139-142.
  • Tam, P., So, C., Cheah, K. (2001). Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis. Osteoarthritis and Cartilage, 9.
  • Orford, J., Manglick, P., Cass, D., Tam, P. (2001). Mechanisms for the development of esophageal atresia. Journal of Pediatric Surgery, 36(7), 985-994.
  • Tam, P., Kinder, S., Tsang, T., Gad, J., Behringer, R. (2001). Morphogenetic tissue movement and the establishment of body plan during development from blastocyst to gastrula in the mouse. BioEssays, 23, 508-517.
  • Tsang, T., Tam, P., Khoo,, P., Jamieson, R., Zhou,, S., Ang,, S., Behringer, R. (2001). The allocation and differentiation of mouse primordial germ cells. International Journal of Developmental Biology, 45, 549-555.
  • Kinder, S., Tsang, T., Tam, P., Wakamiya, M., Sasaki, H., Behringer, R., Nagy,, A. (2001). The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development (Cambridge), 128, 3623-3634.

Conferences

  • Tanaka, S., Yamaguchi, Y., Tam, P. (2007). Experimental approaches to study gene function in whole mouse embryo and fetal ovary in vitro. 7th Transgenic Technology (TT) Meeting (TT2007), Netherlands: Springer-Verlag Dordrecht.

Other

2014

  • Tanaka, S., Yamaguchi, Y., Jones, V., Tam, P. (2014). Analyzing gene function in whole mouse embryo and fetal organ in vitro. (pp. 367-393). [More Information]
  • Loebel, D., Radziewic, T., Power, M., Studdert, J., Tam, P. (2014). Generation of mouse embryos with small hairpin RNA-mediated knockdown of gene expression. In Mark Lewandoski (Eds.), Mouse Molecular Embryology: Methods in Molecular Biology, (pp. 119-142). United States: Humana Press. [More Information]
  • Gold, W., Williamson, S., Kaur, S., Hargreaves, I., Land, J., Pelka, G., Tam, P., Christodoulou, J. (2014). Mitochondrial dysfunction in the skeletal muscle of a mouse model of Rett syndrome (RTT): Implications for the disease phenotype. Mitochondrion, 15, 10-17. [More Information]

2013

  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Devleopment, 27(1), 18-23. [More Information]
  • Maxwell, S., Pelka, G., Tam, P., El-Osta, A. (2013). Chromatin context and ncRNA highlight targets of MeCP2 in brain. RNA Biology, 10(11), 1741-1757. [More Information]
  • Tanaka, S., Nakane, A., Yamaguchi, Y., Terabayashi, T., Abe, T., Nakao, K., Asashima, M., Steiner, K., Tam, P., Nishinakamura, R. (2013). Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo. PLoS One, 8(3), 1-14. [More Information]
  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
  • Tam, P., Nelson, W., Rossant, J. (2013). Mammalian Development: Networks, Switches, and Morphogenetic Processes. New York: Cold Spring Harbor Laboratory Press.
  • Stephenson, R., Rossant, J., Tam, P. (2013). Reprint: Intercellular Interactions, Position, and Polarity in Establishing Blastocyst Cell Lineages. In Patrick P. L. Tam, W. James Nelson, Janet Rossant (Eds.), Mammalian Development: Networks, Switches, and Morphogenetic Processes, (pp. 167-182). New York: Cold Spring Harbor Laboratory Press.
  • Tam, P., Pera, M. (2013). Stem cell science and regenerative medicine. BioEssays : news and reviews in molecular cellular and developmental biology, 35(3), 147-148. [More Information]
  • Bildsoe, H., Loebel, D., Jones, V., Hor, A., Braithwaite, A., Chen, Y., Behringer, R., Tam, P. (2013). The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss fof Twist1 function. Developmental Biology, 374(2), 295-307. [More Information]
  • Ng, H., Tam, P. (2013). The mystique of cellular reprogramming. Current Opinion in Genetics & Development, 23(5), 501-503. [More Information]
  • Arkell, R., Fossat, N., Tam, P. (2013). Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output. Current Opinion in Genetics & Development, 23(4), 454-460. [More Information]

2012

  • Williamson, S., Giudici, L., Kilstrup-Nielsen, C., Gold, W., Pelka, G., Tam, P., Grimm, A., Prodi, D., Landsberger, N., Christodoulou, J. (2012). A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain. Human Genetics, 131(2), 187-200. [More Information]
  • Arkell, R., Tam, P. (2012). Initiating head development in mouse embryos: integrating signalling and transcriptional activity. Open Biology, 2(March 2012), 1-10. [More Information]
  • Stephenson, R., Rossant, J., Tam, P. (2012). Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. Cold Spring Harbor Perspectives in Biology, 4(11), 1-15. [More Information]
  • Fossat, N., Jones, V., Garcia-Garcia, M., Tam, P. (2012). Modulation of WNT signaling activity is key to the formation of the embryonic head. Cell Cycle, 11(1), 26-32. [More Information]
  • Loebel, D., Hor, A., Bildsoe, H., Jones, V., Chen, Y., Behringer, R., Tam, P. (2012). Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton. Developmental Biology, 362(2), 132-140. [More Information]
  • Loebel, D., Tam, P. (2012). Rho GTPases in endoderm development and differentiation. Small GTPases, 3(1), 40-44. [More Information]

2011

  • Tam, P. (2011), Endoderm Formation: Not So Black and White Anymore. [More Information]
  • Coombes, A., Bowles, J., Feng, C., Chiu, H., Khoo, P., Jackson, A., Little, M., Tam, P., Koopman, P. (2011). Expression and functional analysis of Dkk1 during early gonadal development. Sexual Development, 5(3), 124-130. [More Information]
  • Tanaka, S., Kojima, Y., Yamaguchi, Y., Nishinakamura, R., Tam, P. (2011). Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo. Development, Growth and Differentiation, 53(7), 843-856. [More Information]
  • Fossat, N., Loebel, D., Jones, V., Khoo, P., Bildsoe, H., Tam, P. (2011). Marking Cells for Imaging Analysis of Morphogenetic Behavior and Cell Fates in Mouse Embryos. In James Sharpe, Rachel Wong (Eds.), Imaging in Developmental Biology: A Laboratory Manual, (pp. 311-329). Woodbury, New York, USA: Cold Spring Harbor Laboratory Press.
  • Loebel, D., Studdert, J., Power, M., Radziewic, T., Jones, V., Coultas, L., Jackson, Y., Rao, R., Steiner, K., Fossat, N., Tam, P., et al (2011). Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development (Cambridge), 138(20), 4511-4522. [More Information]
  • Pfister, S., Jones, V., Power, M., Truisi, G., Khoo, P., Steiner, K., Kanai-Azuma, M., Kanai, Y., Tam, P., Loebel, D. (2011). Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. International Journal of Developmental Biology. [More Information]
  • Fossat, N., Jones, V., Khoo, P., Bogani, D., Hardy, A., Steiner, K., Mukhopadhyay, M., Westphal, H., Nolan, P., Arkell, R., Tam, P. (2011). Stringent Requirement of a Proper Level of Canonical WNT Signalling Activity for Head Formation in Mouse Embryo. Development (Cambridge), 138(4), 667-676. [More Information]

2010

  • Harikrishnan, K., Bayles, R., Ciccotosto, G., Maxwell, S., Cappai, R., Pelka, G., Tam, P., Christodoulou, J., El-Osta, A. (2010). Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons. The Journal of Neuroscience, 30(4), 1494-1501. [More Information]
  • Rivera-Perez, J., Jones, V., Tam, P. (2010). Culture of Whole Mouse Embryos at Early Postimplantation to Organogenesis Stages: Developmental Staging and Methods. In Paul M. Wassarman & Philippe M. Soriano (Eds.), Methods in Enzymology Volume 476: Guide to Techniques in Mouse Development, Part A: Mice, Embryos, and Cells, (pp. 185-203). United States: Elsevier.
  • Pera, M., Tam, P. (2010). Extrinsic regulation of pluripotent stem cells. Nature, 465(7299), 713-720. [More Information]
  • Tanaka, S., Yamaguchi, Y., Steiner, K., Nakano, T., Nishinakamura, R., Kwan, K., Behringer, R., Tam, P. (2010). Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse. Developmental Dynamics, 239(11), 2851-2859. [More Information]
  • Leung, A., Wong, S., Chan, D., Tam, P., Cheah, K. (2010). Loss of Procollagen IIA From the Anterior Mesendoderm Disrupts the Development of Mouse Embryonic Forebrain. Developmental Dynamics, 239(9), 2319-2329. [More Information]
  • Fath, T., Chan, Y., Vrhovski, B., Clarke, H., Curthoys, N., Hook, J., Lemckert, F., Schevzov, G., Tam, P., Watson, C., Gunning, P., et al (2010). New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2. European Journal of Cell Biology, 89(7), 489-498. [More Information]
  • Weaving, L., Mihelec, M., Storen, R., Sosic, D., Grigg, J., Tam, P., Jamieson, R. (2010). Twist2: Role in Corneal Stromal Keratocyte Proliferation and Corneal Thickness. Investigative Ophthalmology and Visual Science, 51(11), 5561-5570. [More Information]

2009

  • Rossant, J., Tam, P. (2009). Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development (Cambridge), 136(5), 701-713. [More Information]
  • Mihelec, M., Abraham, P., Gibson, K., Krowka, R., Susman, R., Storen, R., Chen, Y., Donald, J., Tam, P., Flaherty, M., Grigg, J., Jamieson, R., et al (2009). Novel SOX2 partner-factor domain mutation in a four-generation family. European Journal of Human Genetics, 17(11), 1417-1422. [More Information]
  • Bildsoe, H., Loebel, D., Jones, V., Chen, Y., Behringer, R., Tam, P. (2009). Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Developmental Biology, 331(2), 176-188. [More Information]
  • Tam, P., Loebel, D. (2009). Specifying mouse embryonic germ cells. Cell, 137(3), 398-400. [More Information]
  • Grassinger, J., Haylock, D., Storan, M., Haines, G., Williams, B., Whitty, G., Vinson, A., Be, C., Li, S., Tam, P. (2009). Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with α9β1 and α4β1 integrins. Blood, 114(1), 49-59. [More Information]

2008

  • Watson, C., Trainor, P., Radziewic, T., Pelka, G., Zong, Z., Parameswaran, M., Quinlan, G., Gordon, M., Sturm, K., Tam, P., et al (2008). Application of lacZ Transgenic Mice to Cell Lineage Studies. Methods in Molecular Biology, 461, 149-164. [More Information]
  • Furtado, M., Solloway, M., Jones, V., Costa, M., Biben, C., Wolstein, O., Preis, J., Sparrow, D., Saga, Y., Dunwoodie, S., et al (2008). BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes and Development, 22, 3037-3049. [More Information]
  • Quinlan, G., Khoo, P., Wong, N., Trainor, P., Tam, P. (2008). Cell grafting and labeling in postimplantation mouse embryos. Methods in Molecular Biology, 461, 47-70. [More Information]
  • Mihelec, M., St Heaps, L., Flaherty, M., Billson, F., Rudduck, C., Tam, P., Grigg, J., Peters, G., Jamieson, R. (2008). Chromosomal Rearrangements and Novel Genes in Disorders of Eye Development, Cataract and Glaucoma. Twin Research and Human Genetics, 11(4), 412-421. [More Information]
  • Lewis, S., Khoo, P., Young, A., Steiner, K., Willcock, C., Mukhopadhyay, M., Westphal, H., Jamieson, R., Robb, L., Tam, P. (2008). Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development (Cambridge), 135(10), 1791-1801. [More Information]
  • Kondo, M., Gray, L., Pelka, G., Christodoulou, J., Tam, P., Hannan, A. (2008). Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome - Mecp2 gene dosage effects and BDNF expression. European Journal of Neuroscience, 27(12), 3342-3350. [More Information]
  • Franklin, V., Khoo, P., Bildsoe, H., Wong, N., Lewis, S., Tam, P. (2008). Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo. Mechanisms of Development, 125(7), 587-600. [More Information]

2007

  • Fossat, N., Pfister, S., Tam, P. (2007). A transcriptome landscape of mouse embryogenesis. Developmental Cell, 13(6), 761-762. [More Information]
  • Tam, P., Lovell-Badge, R. (2007). Anne McLaren 1927-2007. Cell, 130(2), 201-213. [More Information]
  • Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al (2007). Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More Information]
  • Tanaka, S., Yamaguchi, Y., Tam, P. (2007). Experimental approaches to study gene function in whole mouse embryo and fetal ovary in vitro. 7th Transgenic Technology (TT) Meeting (TT2007), Netherlands: Springer-Verlag Dordrecht.
  • Franklin, V., Bildsoe, H., Tam, P. (2007). Fate-Mapping Technique: Grafting Fluorescent Cells into Gastrula-Stage Mouse Embryos at 7-7.5 Days Post-coitum. CSH protocols, 2007, 4892. [More Information]
  • Khoo, P., Franklin, V., Tam, P. (2007). Fate-Mapping Technique: Targeted Whole-Embryo Electroporation of DNA Constructs into the Germ Layers of Mouse Embryos 7-7.5 Days Post-coitum. CSH protocols, 2007, 4893. [More Information]
  • Bildsoe, H., Franklin, V., Tam, P. (2007). Fate-mapping technique: using carbocyanine dyes for vital labeling of cells in gastrula-stage mouse embryos cultured in vitro. CSH protocols, 2007, 4915. [More Information]
  • Pfister, S., Steiner, K., Tam, P. (2007). Gene expression pattern and progression of embryogenesis in the immediate post-implantation period of mouse development. Gene Expression Patterns, 7(5), 558-573. [More Information]
  • Tam, P., Loebel, D. (2007). Gene function in mouse embryogenesis: get set for gastrulation. Nature Reviews Genetics, 8(5), 368-381. [More Information]
  • Lewis, S., Khoo, P., De Young, R., Bildsoe, H., Wakamiya, M., Behringer, R., Mukhopadhyay, M., Westphal, H., Tam, P. (2007). Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mechanisms of Development, 124(2), 157-165. [More Information]
  • Tam, P., Khoo, P., Lewis, S., Bildsoe, H., Wong, N., Tsang, T., Gad, J., Robb, L. (2007). Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development (Cambridge), 134(2), 251-260. [More Information]

2006

  • Tam, P., Loebel, D., Tanaka, S. (2006). Building the mouse gastrula: signals, asymmetry and lineages. Current Opinion In Genetics and Development, 16(4), 419-425. [More Information]
  • Willcock, C., Grigg, J., Wilson, M., Tam, P., Billson, F., Jamieson, R. (2006). Congenital iris ectropion as an indicator of variant aniridia. The British Journal of Ophthalmology, 90(5), 658-659.
  • Lewis, S., Tam, P. (2006). Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function. Developmental Dynamics, 235(9), 2315-2329. [More Information]
  • Nolen, L., Amor, D., Haywood, A., St. Heaps, L., Willcock, C., Mihelec, M., Tam, P., Billson, F., Grigg, J., Peters, G., Jamieson, R. (2006). Deletion at 14q22-23 indicates a contiguous gene syndrome comprising anophthalmia, pituitary hypoplasia, and ear anomalies. American Journal of Medical Genetics. Part A, 140(16), 1711-1718. [More Information]
  • Duffy, S., Steiner, K., Tam, P., Boyd, A. (2006). Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development. Gene Expression Patterns, 6(7), 719-723. [More Information]
  • Yamaguchi, Y., Tanaka, S., Kasa, M., Yasuda, K., Tam, P., Matsui, Y. (2006). Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells. Gene Expression Patterns, 6(6), 607-612. [More Information]
  • Pelka, G., Watson, C., Radziewic, T., Hayward, M., Lahooti, H., Christodoulou, J., Tam, P. (2006). Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain, 129(Pt 4), 887-898. [More Information]
  • Yamaguchi, Y., Tanaka, S., Yasuda, K., Matsui, Y., Tam, P. (2006). Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Developmental Biology, 297(2), 350-360. [More Information]

2005

  • Loebel, D., Tsoi, B., Wong, N., Tam, P. (2005). A conserved noncoding intronic transcript at the mouse Dnm3 locus. Genomics. [More Information]
  • Loebel, D., Tam, P. (2005). A gut feeling. Nature Biotechnology, 23(12), 1491-1492. [More Information]
  • Pelka, G., Watson, C., Christodoulou, J., Tam, P. (2005). Distinct expression profiles of Mecp2 transcripts with different lengths of 3'UTR in the brain and visceral organs during mouse development. Genomics, 85(4), 441-452. [More Information]
  • Tanaka, S., Yamaguchi, Y., Tsoi, B., Lickert, H., Tam, P. (2005). IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Developmental Cell, 9(6), 745-756. [More Information]
  • Watson, C., Pelka, G., Radziewic, T., Shahbazian, M., Christodoulou, J., Williamson, S., Tam, P. (2005). Reduced proportion of Purkinje cells expressing paternally derived mutant Mecp2 308 allele in female mouse cerebellum is not due to a skewed primary pattern of X-chromosome inactivation. Human Molecular Genetics, 14(13), 1851-1861. [More Information]

2004

  • Ding, H., Wu, X., Bostrom, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G., Soriano, P., Betsholtz, C., Tam, P., et al (2004). A Specific Requirement For PDGF-C In Palate Formation And PDGFR-Alpha Signaling. Nature Genetics, 36(10), 1111-1116.
  • Tam, P. (2004). Embryonic Axes: The Long And Short Of It In The Mouse. Current Biology, 14(6), R239-R241. [More Information]
  • Rossant, J., Tam, P. (2004). Emerging Asymmetry And Embryonic Patterning In Early Mouse Development. Developmental Cell, 7(2), 155-164. [More Information]
  • Robb, L., Tam, P. (2004). Gastrula Organiser And Embryonic Patterning In The Mouse. Seminars in Cell and Developmental Biology, 15(5), 543-554.
  • Weaving, L., Christodoulou, J., Williamson, S., Friend, K., McKenzie, O., Archer, H., Evans, J., Clarke, A., Pelka, G., Tam, P., Lahooti, H., Ellaway, C., Bennetts, B., Watson, C., et al (2004). Mutations Of Cdkl5 Cause A Severe Neurodevelopmental Disorder With Infantile Spasms And Mental Retardation. American Journal of Human Genetics, 75, 1079-1093.
  • Tam, P., Khoo, P., Wong, N., Tsang, T., Behringer, R. (2004). Regionalization Of Cell Fates And Cell Movement In The Endoderm Of The Mouse Gastrula And The Impact Of Loss Of Lhx1(Lim1) Function. Developmental Biology, 274(1), 171-187.
  • Tanaka, S., Nagamatsu, G., Tokitake, Y., Kasa, M., Tam, P., Matsui, Y. (2004). Regulation Of Expression Of Mouse Interferon-Induced Transmembrane Protein Like Gene-3, Ifitm3 (Mil-1, Fragilis), In Germ Cells. Developmental Dynamics, 230(4), 651-659. [More Information]
  • Ding, H., Schertzer, M., Wu, X., Gertsenstein, M., Selig, S., Kammori, M., Pourvali, R., Poon, S., Vulto, I., et, A., Tam, P. (2004). Regulation Of Murine Telomere Length By Rtel: An Essential Gene Encoding A Helicase-Like Protein. Cell, 117(7), 873-886. [More Information]
  • Loebel, D., Tsoi, B., Wong, N., O'Rourke, M., Tam, P. (2004). Restricted Expression Of Etn-Related Sequences During Post-Implantation Mouse Development. Gene Expression Patterns, 4(4), 467-471.

2003

  • Hukriede, N., Tsang, T., Habas, R., Khoo, P., Steiner, K., Weeks, D., Tam, P., Dawid, I. (2003). Conserved requirement of Lim1 function for cell movements during gastrulation. Developmental Cell, 4(1), 83-94.
  • Tam, P., Kanai-Azuma, M., Kanai, Y. (2003). Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Current Opinion In Genetics and Development, 13(4), 393-400.
  • Loebel, D., Watson, C., De Young, R., Tam, P. (2003). Lineage choice and differentiation in mouse embryos and embryonic stem cells. Developmental Biology, 264(1), 1-14.
  • Tam, P., Rossant, J. (2003). Mouse embryonic chimeras: tools for studying mammalian development. Development (Cambridge), 130, 6155-6163.

2002

  • Stone, L., Tan, S., Tam, P., Finger, T. (2002). Analysis of Cell Lineage Relationships in Taste Buds. The Journal of Neuroscience, 22(11), 4522-4529.
  • Kanai-Azuma, M., Kanai, Y., Gad, J., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P., et al (2002). Depletion of definitive gut endoderm in Sox17-null mutant mice. Development (Cambridge), 129(10), 2367-2379.
  • Ristevski, S., Tam, P., Hertzog, P., Kola, I. (2002). Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo. Mechanisms of Development, 116, 165-168.
  • Tam, P. (2002). First mitotic division: getting it right at the start. Nature Cell Biology, 4(10), E232-E232.
  • Loebel, D., Orourke, M., Steiner, K., Banyer, J., Tam, P. (2002). Isolation of Differentially Expressed Genes from Wild-Type and Twist Mutant Mouse Limb Buds. Genesis, 33(3), 103-113. [More Information]
  • Hart, A., Hartley, L., Sourris, K., Stadler, E., Li, R., Stanley, E., Tam, P., Elefanty, A., Robb, L. (2002). Mixl1 is required for axial mesendoderm morpogenesis and patterning in the murine embryo. Development (Cambridge), 129(15), 3597-3608.
  • Tam, P., Rossant, J. (2002). Mouse Development: Patterning, Morphogenesis and Organogensis. San Francisco United States: Academic Press Elsevier.
  • Tam, P., Gossler, A. (2002). Somitogenesis: Segmentation of the Paraxial Mesodeerm and the delineation of tissue compartments. In Janet Rossant & Patrick L. Tam (Eds.), Mouse Development, (pp. 127-149). San Francisco: Staempfli Publishers Ltd.
  • Soo, K., Orourke, M., Khoo, P., Steiner, K., Wong, N., Behringer, R., Tam, P. (2002). Twist Function is Required for morphogenesis of the Cephalic Neural Tuve and the Differentiation of the Cranial Neura Crest Cells in the Mouse Embryo. Developmental Biology, 247(2), 251-270. [More Information]
  • Orourke, M., Tam, P. (2002). Twist Functions in mouse development. International Journal of Developmental Biology, 46(4), 401-413.
  • Orourke, M., Soo, K., Behringer, R., Hui, C., Tam, P. (2002). Twist plays an essential role in FGF and SHH Signal Transduction during Mouse Limb Development. Developmental Biology, 248(1), 143-156. [More Information]

2001

  • Kinder, S., Tam, P., Loebel, D. (2001). Allocation and Early Differentiation of Cardiovascular Progenitors in the Mouse Embryo. Trends In Cardiovascular Medicine, 11, 177-183.
  • Tam, P., Hadjantonakis, A., Cox,, L., Nagy,, A. (2001). An X-linked GFP transgene reveals unexpected paternal X-Chromosome activity in trophoblastic Giant Cells of the Mouse Placenta. Genesis, 29, 133-140.
  • Tam, P., Watson,, C. (2001). Cell Lineage Determination in the Mouse. Cell Structure and Function, 26, 123-129.
  • Kinder, S., Tsang, T., Tam, P., Ang,, S., Behringer, R. (2001). Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3B activity. International Journal of Developmental Biology, 45, 347-355.
  • Tam, P., Ristevski, S., Kola,, I., Hertzog, P. (2001). Desrt, an AT-rich interaction domain family transcription factor gene, is an early marker for nephrogenic mesoderm and is expressed dynamically during mourse limb development. Mechanisms of Development, 104, 139-142.
  • Tam, P., So, C., Cheah, K. (2001). Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis. Osteoarthritis and Cartilage, 9.
  • Orford, J., Manglick, P., Cass, D., Tam, P. (2001). Mechanisms for the development of esophageal atresia. Journal of Pediatric Surgery, 36(7), 985-994.
  • Tam, P., Kinder, S., Tsang, T., Gad, J., Behringer, R. (2001). Morphogenetic tissue movement and the establishment of body plan during development from blastocyst to gastrula in the mouse. BioEssays, 23, 508-517.
  • Tsang, T., Tam, P., Khoo,, P., Jamieson, R., Zhou,, S., Ang,, S., Behringer, R. (2001). The allocation and differentiation of mouse primordial germ cells. International Journal of Developmental Biology, 45, 549-555.
  • Kinder, S., Tsang, T., Tam, P., Wakamiya, M., Sasaki, H., Behringer, R., Nagy,, A. (2001). The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development (Cambridge), 128, 3623-3634.

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