People_

Professor Patrick Tam

PhD FAA FAHMS FRSB FRS

Professor and NHMRC Senior Principal Research Fellow
Medicine
Children's Medical Research Institute
Faculty of Medicine and Health

Phone

+61 2 8865 2911

Fax

+61 2 8865 2801

patrick.tam@sydney.edu.au

Biographical details

Professor Patrick Tam is the Deputy Director and Head of the Embryology Research Unit at the Children's Medical Research Institute, Senior Principal Research Fellow of the National Health and Medical Research Council (NHMRC) of Australia and Professor in the School of Medical Sciences of Sydney Medical School at University of Sydney. Professor Tam is also the Mok Hing-Yiu Distinguished Visiting Professor at the School of Biomedical Sciences of University of Hong Kong.

Research interests

Professor Tam's research focuses on the systems-based investigation of the gene regulatory network underpinning the cellular and molecular mechanisms of body patterning during mouse development and the biology of stem cells. He pioneered the application of micromanipulation and embryo culture for analyzing mouse embryos and examining the development of the head and embryonic gut. The embryological analysis undertaken by his team at CMRI has enabled the construction of a series of fate-maps revealing the organization of the basic body plan of the early embryo. The in-depth knowledge of cell differentiation during early embryogenesis laid the foundation for directing the differentiation of stem cells into clinically useful cell types for therapy in regenerative medicine

Current projects

Current research areas: 1. Developmental fate and lineage differentiation during embryogenesis 2. Gene regulatory network activity in head development 3. Transcriptional regulation and craniofacial development of normal and mutant embryos 4. Differentiation and organogenesis of endodermal tissues and the role of RNA binding protein 5. Developmental biology of embryo-derived stem cells and induced pluripotent stem cells

Awards and honours

1975 Chan Kai Ming Prize for the best Biology graduate in the Class of 1975, University of Hong Kong.

1977-1980 British Commonwealth Scholarship tenable in the United Kingdom to pursue postgraduate (Ph.D.) study in mammalian development at the University College London.

1986 Croucher Foundation Fellowship tenable at the University of Oxford as a Visiting Scientist at the Imperial Cancer Research Fund Developmental Biology Unit for collaborative research with Dr Rosa Beddington.

1987 The Symington Memorial Prize in Anatomy of the Anatomical Society of Great Britain and Ireland. Awarded for the first time to a member outside the UK.

1988 Best Teaching Award (Pre-clinical Sciences) of the Faculty of Medicine at The Chinese University of Hong Kong.

1989 Fellow of the Institute of Biology UK (FIBiol)

1996-2000 Visiting Professor, Department of Biochemistry, Faculty of Medicine, University of Hong Kong

1997-2000 Principal Research Fellowship of the National Health and Medical Research Council of Australia.

1998 JH Blaffer Lecturer, University of Texas MD Anderson Cancer Center, USA A named Lecture series of the Program in Genes and Development of the Department of Biochemistry and Molecular Biology and Department of Molecular Genetics.

2001-2020 Senior Principal Research Fellowship of the National Health and Medical Research Council of Australia.

2001 Rosa Beddington Memorial lecturer, Mouse Molecular Genetics Meeting, European Molecular Biology Laboratory

2014-2017 Honorary Professor, Department of Biochemistry, Li Ka Shing Faculty of Medicine, University of Hong Kong

2002 The Lo Yuk Tong Foundation Lecturer, University of Hong Kong.

2002, 2003 National Scientific Advisor, ComBio Conference National Advisory Committee

2003 The S T Huang Chan Memorial Lecturer, Faculty of Medicine, University of Hong Kong.

2005 Rosa Beddington Memorial lecturer, Mouse Molecular Genetics Meeting, European Molecular Biology Laboratory I

2006 Wellcome Trust Principal Research Fellowship (2007-2014) tenable at University College London UK (declined).

2007 The President’s Medallist of the Australian and New Zealand Society for Cell and Developmental Biology

2007 Lecturer, Barabara Ell Seminar Series. A named lecture series commemorated with a medal of the Victor Chang Cardiac Research Institute.

2008 Fellow of Australian Academy of Science (FAA)

2009 Fellow of the Society of Biology (FSB)

2011 Fellow of the Royal Society of London (FRS)

2012-2016 Mok Hing-Yiu Distinguished Visiting Professor, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong.

2015 Fellow of the Royal Society of Biology (FRSB) This fellowship superceded FSB after the transition of the the Society of Biology UK to the Royal Society of Biology

2015 Fellow of the Australian Academy of Health and Medical Sciences (FAHMS)

2017 Distringuished Professorial Achievement Award, Sydney Medical School

2018 Anne McLaren Memorial Lecturer, International Society for Stem Cell Research

2019 Julian Wells Medal, Lorne Genome Conference

Themes

Reproductive, Maternal and Child Health

Keywords

Embryology, Genetic processes, Genetics, Stem cells, Birth defects

Approaches

Animal Models, Cellular/Molecular, Genetics

Clinical speciality

Paediatrics

PhD and master's project opportunities

Control of cell differentiation during mouse embryogenesis and stem cell development

Selected publications

Mammalian Development: Networks, Switches, and Morphogenetic Processes

(Cold Spring Harbor Laboratory Press, 2013)

Mouse Development: Patterning, Morphogenesis and Organogensis

(Academic Press, 2002)

Publications

By Type

Expand all

Edited Books

Tam, P., Nelson, W., Rossant, J. (2013). Mammalian Development: Networks, Switches, and Morphogenetic Processes. New York: Cold Spring Harbor Laboratory Press.
Tam, P., Rossant, J. (2002). Mouse Development: Patterning, Morphogenesis and Organogensis. San Francisco United States: Academic Press.

Book Chapters

Sibbritt, T., Osteil, P., Fan, X., Sun, J., Salehin, N., Knowles, H., Shen, J., Tam, P. (2019). Gene Editing of Mouse Embryonic and Epiblast Stem Cells. In Ivan Bertoncello (Eds.), Mouse Cell Culture: Methods and Protocols, (pp. 77-95). New York: Springer. [More Information]
Tanaka, S., Yamaguchi, Y., Jones, V., Tam, P. (2014). Analyzing gene function in whole mouse embryo and fetal organ in vitro. In Mark Lewandoski (Eds.), Mouse Molecular Embryology: Methods and Protocols, (pp. 367-393). New York: Humana Press. [More Information]
Loebel, D., Radziewic, T., Power, M., Studdert, J., Tam, P. (2014). Generation of mouse embryos with small hairpin RNA-mediated knockdown of gene expression. In Mark Lewandoski (Eds.), Mouse Molecular Embryology: Methods and Protocols, (pp. 119-142). New York: Humana Press. [More Information]
Stephenson, R., Rossant, J., Tam, P. (2013). Reprint: Intercellular Interactions, Position, and Polarity in Establishing Blastocyst Cell Lineages. In Patrick P. L. Tam, W. James Nelson, Janet Rossant (Eds.), Mammalian Development: Networks, Switches, and Morphogenetic Processes, (pp. 167-182). New York: Cold Spring Harbor Laboratory Press.
Fossat, N., Loebel, D., Jones, V., Khoo, P., Bildsoe, H., Tam, P. (2011). Marking Cells for Imaging Analysis of Morphogenetic Behavior and Cell Fates in Mouse Embryos. In James Sharpe, Rachel Wong (Eds.), Imaging in Developmental Biology: A Laboratory Manual, (pp. 311-329). Woodbury, New York, USA: Cold Spring Harbor Laboratory Press.
Rivera-Perez, J., Jones, V., Tam, P. (2010). Culture of Whole Mouse Embryos at Early Postimplantation to Organogenesis Stages: Developmental Staging and Methods. In Paul M. Wassarman and Philippe M. Soriano (Eds.), Methods in Enzymology Volume 476: Guide to Techniques in Mouse Development, Part A: Mice, Embryos, and Cells, (pp. 185-203). United States: Elsevier. [More Information]
Tam, P., Gossler, A. (2002). Somitogenesis: Segmentation of the Paraxial Mesodeerm and the delineation of tissue compartments. In Janet Rossant & Patrick L. Tam (Eds.), Mouse Development, (pp. 127-149). San Francisco: Staempfli Publishers Ltd.

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Journals

Clark, A., Goolam, M., Hanna, J., Long, K., Nicol, D., Petropoulos, S., Saitou, M., Tam, P., Wang, H. (2024). Human developmental biology – a global perspective. Development, 151(17), dev203092. [More Information]
McMahon, R., Masamsetti, V., Tam, P. (2024). Phenotypic Analysis of Early Neurogenesis in a Mouse Chimeric Embryo and Stem Cell-Based Neuruloid Model. Methods in Molecular Biology, 2746, 165-177. [More Information]
Wu, Z., Zhao, Q., Kim, D., Yang, P., Hill, T., Jones, A., Fairlie, D., Pébay, A., Hewitt, A., Tam, P., et al (2024). Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Developmental Cell, 59(6), 705-722.e8. [More Information]
Wang, R., Peng, G., Tam, P., Jing, N. (2023). Integration of Computational Analysis and Spatial Transcriptomics in Single-cell Studies. Genomics Proteomics and Bioinformatics, 21(1), 13-23. [More Information]
Newman, P., Yip, Q., Osteil, P., Anderson, T., Sun, J., Kempe, D., Biro, M., Shin, J., Tam, P., Zreiqat, H. (2023). Programming of Multicellular Patterning with Mechano-Chemically Microstructured Cell Niches. Advanced Science. [More Information]
Rugg-Gunn, P., Moris, N., Tam, P. (2023). Technical challenges of studying early human development. Development, 150(11). [More Information]
Wang, R., Yang, X., Chen, J., Zhang, L., Griffiths, J., Cui, G., Chen, Y., Qian, Y., Peng, G., Li, J., Tam, P., et al (2023). Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nature Communications, 14(1). [More Information]
Knowles, H., Santucci, N., Studdert, J., Goh, H., Kaufman-Francis, K., Salehin, N., Tam, P., Osteil, P. (2022). Differential impact of TGFÎ²/SMAD signaling activity elicited by Activin A and Nodal on endoderm differentiation of epiblast stem cells. Genesis, 60(1-Feb), e23466. [More Information]
Rossant, J., Tam, P. (2022). Early human embryonic development: Blastocyst formation to gastrulation. Developmental Cell, 57(2), 152-165. [More Information]
Salehin, N., Santucci, N., Osteil, P., Tam, P. (2022). Exploring Chromatin Accessibility in Mouse Epiblast Stem Cells with ATAC-Seq. Methods in Molecular Biology, 2490, 93-100. [More Information]
Tsang, T., Finlay-Jones, A., Perry, K., Grigg, J., Popova, S., Cheung, M., Bower, C., Tam, P., Jamieson, R., Elliott, E. (2022). Eye Abnormalities in Children with Fetal Alcohol Spectrum Disorders: A Systematic Review. Ophthalmic Epidemiology. [More Information]
Osteil, P., Studdert, J., Tam, P. (2022). Grafting of Epiblast Stem Cell into the Epiblast and Whole-Embryo Imaging to Unveil Lineage Competence. Methods in Molecular Biology, 2490, 269-279. [More Information]
Masamsetti, V., Tam, P. (2022). Identification and Visualization of Protein Expression in Whole Mouse Embryos by Immunofluorescence. Methods in Molecular Biology, 2490, 39-45. [More Information]
McMahon, R., Sibbritt, T., Aryamanesh, N., Masamsetti, V., Tam, P. (2022). Loss of Foxd4 Impacts Neurulation and Cranial Neural Crest Specification During Early Head Development. Frontiers in Cell and Developmental Biology, 9, 777652. [More Information]
Salehin, N., Knowles, H., Masamsetti, V., Tam, P. (2022). Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation. Biochemical Society Transactions, 50(6), 1619-1631. [More Information]
Haase, F., Singh, R., Gloss, B., Tam, P., Gold, W. (2022). Meta-Analysis Identifies BDNF and Novel Common Genes Differently Altered in Cross-Species Models of Rett Syndrome. International Journal of Molecular Sciences, 23(19). [More Information]
Yang, P., Tam, P. (2022). Mouse organogenesis atlas at single-cell resolution. Cell, 185(10), 1625-1627. [More Information]
Peng, G., Tam, P. (2022). Profiling spatial gene activity in marmoset embryos. Cell Research, 32(10), 873-874. [More Information]
Cui, G., Feng, S., Yan, Y., Wang, L., He, X., Li, X., Duan, Y., Chen, J., Tang, K., Zheng, P., Tam, P., et al (2022). Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo. Cell Reports, 40(9). [More Information]
Nim, H., Dang, L., Thiyagarajah, H., Bakopoulos, D., See, M., Charitakis, N., Sibbritt, T., Eichenlaub, M., Archer, S., Fossat, N., Tam, P., et al (2021). A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease. Genome Biology, 22(1), 1-21. [More Information]
Kim, H., Tam, P., Yang, P. (2021). Defining cell identity beyond the premise of differential gene expression. Cell Regeneration, 10(1), 20-3 pages. [More Information]
Rossant, J., Tam, P. (2021). Opportunities and challenges with stem cell-based embryo models. Stem Cell Reports, 16(5), 1031-1038. [More Information]
Haase, F., Coorey, B., Riley, L., Cantrill, L., Tam, P., Gold, W. (2021). Pre-clinical Investigation of Rett Syndrome Using Human Stem Cell-Based Disease Models. Frontiers in Neuroscience, 15, 698812. [More Information]
Fan, X., Masamsetti, V., Sun, J., Engholm-Keller, K., Osteil, P., Studdert, J., Graham, M., Fossat, N., Tam, P. (2021). TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. eLife, 10, e62873-1-e62873-33. [More Information]
Kim, H., Wang, K., Chen, C., Lin, Y., Tam, P., Lin, D., Yang, J., Yang, P. (2021). Uncovering cell identity through differential stability with Cepo. Nature Computational Science, 1(12), 784-790. [More Information]
Haase, F., Gloss, B., Tam, P., Gold, W. (2021). Wgcna identifies translational and proteasome-ubiquitin dysfunction in rett syndrome. International Journal of Molecular Sciences, 22(18), 9954. [More Information]
Peng, G., Suo, S., Cui, G., Yu, F., Wang, R., Chen, J., Chen, S., Liu, Z., Chen, G., Qian, Y., Tam, P., et al (2020). Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature, 577(7791), E6. [More Information]
Tam, P., Ho, J. (2020). Cellular diversity and lineage trajectory: insights from mouse single cell transcriptomes. Development, 147(2), dev179788. [More Information]
Shim, W., Sinniah, E., Xu, J., Vitrinel, B., Alexanian, M., Andreoletti, G., Shen, S., Sun, Y., Balderson, B., Boix, C., Tam, P., et al (2020). Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity. Cell Systems, 11(6), 625-639.e13. [More Information]
Hamada, H., Tam, P. (2020). Diversity of left-right symmetry breaking strategy in animals. F1000Research, 9, 123. [More Information]
Salehin, N., Tam, P., Osteil, P. (2020). Prenet: Predictive network from ATAC-SEQ data. Journal of Bioinformatics and Computational Biology, 18(1), 2040003. [More Information]
Kim, H., Osteil, P., Humphrey, S., Cinghu, S., Oldfield, A., Patrick, E., Wilkie, E., Peng, G., Suo, S., Jothi, R., Tam, P., Yang, P. (2020). Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning. Nucleic Acids Research, 48(4), 1828-1842. [More Information]
Fan, X., Waardenberg, A., Demuth, M., Osteil, P., Sun, J., Loebel, D., Graham, M., Tam, P., Fossat, N. (2020). Twist1 homodimers and heterodimers orchestrate lineage-specific differentiation. Molecular and Cellular Biology, 40(11), 1-20. [More Information]
Osteil, P., Studdert, J., Goh, H., Wilkie, E., Fan, X., Khoo, P., Peng, G., Salehin, N., Knowles, H., Han, J., Fossat, N., Tam, P., et al (2019). Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells. Development, 146(7), 1-14. [More Information]
Gao, X., Nowak-Imialek, M., Chen, X., Chen, D., Herrmann, D., Ruan, D., Chen, A., Eckersley-Maslin, M., Ahmad, S., Lee, Y., Tam, P., et al (2019). Establishment of porcine and human expanded potential stem cells. Nature Cell Biology, 21(6), 687-699. [More Information]
McMahon, R., Sibbritt, T., Salehin, N., Osteil, P., Tam, P. (2019). Mechanistic insights from the LHX1-driven molecular network in building the embryonic head. Development, Growth and Differentiation, 61(5), 327-336. [More Information]
Tam, P. (2019). Modeling the early development of a primate embryo. Science, 366(6467), 798-799. [More Information]
Peng, G., Suo, S., Cui, G., Yu, F., Wang, R., Chen, J., Chen, S., Liu, Z., Chen, G., Qian, Y., Tam, P., et al (2019). Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature, 572, 528-532. [More Information]
Cheng, S., Pei, Y., He, L., Peng, G., Reinius, B., Tam, P., Jing, N., Deng, Q. (2019). Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development. Cell Reports, 26(10), 2593-2607.e3. [More Information]
Humphreys, D., Fossat, N., Demuth, M., Tam, P., Ho, J. (2019). Ularcirc: visualization and enhanced analysis of circular RNAs via back and canonical forward splicing. Nucleic Acids Research, 47(20), 1-17. [More Information]
Sibbritt, T., Ip, C., Khoo, P., Wilkie, E., Jones, V., Sun, J., Shen, J., Peng, G., Han, J., Jing, N., Osteil, P., Tam, P., Fossat, N., et al (2018). A gene regulatory network anchored by LIM homeobox 1 for embryonic head development. Genesis, 56(9), 1-13. [More Information]
Rossant, J., Tam, P. (2018). Exploring early human embryo development. Science, 360(6393), 1075-1076. [More Information]
McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation. Calcified Tissue International, 102(1), 105-116. [More Information]
Cui, G., Suo, S., Wang, R., Qian, Y., Han, J., Peng, G., Tam, P., Jing, N. (2018). Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Development, Growth and Differentiation, 60(8), 463-472. [More Information]
Yu, Z., Tang, P., Wang, J., Bao, S., Shieh, J., Leung, A., Zhang, Z., Gao, F., Wong, S., Hui, A., Tam, P. (2018). Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight, 3(2), 1-21. [More Information]
Friedman, C., Nguyen, Q., Lukowski, S., Helfer, A., Chiu, H., Miklas, J., Levy, S., Suo, S., Han, J., Osteil, P., Tam, P., et al (2018). Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation. Cell Stem Cell, 23(4), 586-598. [More Information]
Liu, C., Wang, R., He, Z., Osteil, P., Wilkie, E., Yang, X., Chen, J., Cui, G., Guo, W., Chen, Y., Tam, P., et al (2018). Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells. Stem Cell Reports, 11(1), 43-57. [More Information]
Yang, J., Ryan, D., Wang, W., Tsang, J., Lan, G., Masaki, H., Gao, X., Antunes, L., Yu, Y., Tam, P., et al (2017). Establishment of mouse expanded potential stem cells. Nature, 550(7676), 393-397. [More Information]
Logan, G., Dane, A., Hallwirth, C., Smyth, C., Wilkie, E., Amaya, A., Zhu, E., Khandekar, N., Ginn, S., Liao, S., Cunningham, S., Sasaki, N., Cabanes Creus, M., Tam, P., Lisowski, L., Alexander, I., et al (2017). Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome. Nature Genetics, 49(8), 1267-1273. [More Information]
Fatima, S., Wagstaff, K., Lieu, K., Davies, R., Tanaka, S., Yamaguchi, Y., Loveland, K., Tam, P., Jans, D. (2017). Interactome of the inhibitory isoform of the nuclear transporter Importin 13. Biochimica et Biophysica Acta, 1864 (3), 546-561. [More Information]
Peng, G., Tam, P., Jing, N. (2017). Lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies. National Science Review, 4(4), 533-542. [More Information]
Rossant, J., Tam, P. (2017). New insights into early human development: lessons for stem cell derivation and differentiation. Cell Stem Cell, 20(1), 18-28. [More Information]
Zamir, L., Singh, R., Nathan, E., Patrick, R., Yifa, O., Yahalom-Ronen, Y., Arraf, A., Schultheiss, T., Suo, S., Han, J., Tam, P., et al (2017). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta. eLife, 6, 1-31. [More Information]
Savatier, P., Osteil, P., Tam, P. (2017). Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff. Stem Cell Research, 19, 104-112. [More Information]
Chiang, I., Fritzsche, M., Thievend, C., Neal, A., Holmes, K., Lagendijk, A., Overman, J., D'Angelo, D., Omini, A., Tam, P. (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144(20), 3847-3848. [More Information]
Chen, J., Suo, S., Tam, P., Han, J., Peng, G., Jing, N. (2017). Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nature Protocols, 12(3), 566-580. [More Information]
Zheng, G., Zhang, J., Zhao, H., Wang, H., Pang, M., Qiao, X., Lee, S., Hsu, T., Tan, T., Lyons, J., Zhao, Y., Loebel, D., Wang, Y., Wang, Y., Wang, Y., Cao, Q., Wang, C., Lee, V., Tam, P., Harris, D., et al (2016). a3 Integrin of Cell-Cell Contact Mediates Kidney Fibrosis by Integrin-Linked Kinase in Proximal Tubular E-Cadherin Deficient Mice. American Journal of Pathology, 186(7), 1847-1860. [More Information]
Kondo, M., Gray, L., Pelka, G., Leang, S., Christodoulou, J., Tam, P., Hannan, A. (2016). Affective dysfunction in a mouse model of Rett syndrome: Therapeutic effects of environmental stimulation and physical activity. Developmental Neurobiology, 76(2), 209-224. [More Information]
Fossat, N., Radziewic, T., Jones, V., Tourle, K., Tam, P. (2016). Conditional restoration and inactivation of Rbm47 reveal its tissue-context requirement for viability and growth. Genesis, 54(3), 115-122. [More Information]
Bildsoe, H., Fan, X., Wilkie, E., Ashoti, A., Jones, V., Power, M., Qin, J., Wang, J., Tam, P., Loebel, D. (2016). Dataset of TWIST1-regulated genes in the cranial mesoderm and a transcriptome comparison of cranial mesoderm and cranial neural crest. Data in Brief, 9, 372-375. [More Information]
Tam, P., Fossat, N., Wilkie, E., Loebel, D., Ip, C., Ramialison, M. (2016). Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network. Current Topics in Developmental Biology, 117, 497-521. [More Information]
Osteil, P., Studdert, J., Wilkie, E., Fossat, N., Tam, P. (2016). Generation of genome-edited mouse epiblast stem cells via a detour through ES cell-chimeras. Differentiation, 91(45), 119-125. [More Information]
Tam, P. (2016). Human Stem Cells Can Differentiate in Post-implantation Mouse Embryos. Cell Stem Cell, 18(1), 3-4. [More Information]
Peng, G., Suo, S., Chen, J., Chen, W., Liu, C., Yu, F., Wang, R., Chen, S., Sun, N., Cui, G., Tam, P., et al (2016). Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell, 36(6), 681-697. [More Information]
Loebel, D., Plageman, T., Tang, T., Jones, V., Muccioli, M., Tam, P. (2016). Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction. Biology Open, 5(2), 130-139. [More Information]
Bildsoe, H., Fan, X., Wilkie, E., Ashoti, A., Jones, V., Power, M., Qin, J., Wang, J., Tam, P., Loebel, D. (2016). Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Developmental Biology, 418(1), 189-203. [More Information]
McShane, S., Mole, M., Savery, D., Greene, N., Tam, P., Copp, A. (2015). Cellular basis of neuroepithelial bending during mouse spinal neural tube closure. Developmental Biology, 404(2), 113-124. [More Information]
Fossat, N., Ip, C., Jones, V., Studdert, J., Khoo, P., Lewis, S., Power, M., Tourle, K., Loebel, D., Kwan, K., Tam, P., et al (2015). Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development, 142(11), 2069-2079. [More Information]
Williamson, S., Ellaway, C., Peters, G., Pelka, G., Tam, P., Christodoulou, J. (2015). Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype. European Journal of Human Genetics, 23(9), 1171-1175. [More Information]
Greenlees, R., Mihelec, M., Yousoof, S., Speidel, D., Wu, S., Rinkwitz, S., Prokudin, I., Perveen, R., Cheng, A., Ma, A., Nash, B., Loebel, D., Grigg, J., Tam, P., Becker, T., Jamieson, R., et al (2015). Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization. Human Molecular Genetics, 24(20), 5789-5804. [More Information]
Pera, M., de Wert, G., Dondorp, W., Lovell-Badge, R., Mummery, C., Munsie, M., Tam, P. (2015). What if stem cells turn into embryos in a dish? Nature Methods, 12(10), 917-919. [More Information]
Fossat, N., Tourle, K., Radziewic, T., Barratt, K., Liebhold, D., Studdert, J., Power, M., Jones, V., Loebel, D., Tam, P. (2014). C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. EMBO Reports, 15(8), 903-910. [More Information]
Kaufman-Francis, K., Goh, H., Kojima, Y., Studdert, J., Jones, V., Power, M., Wilkie, E., Teber, E., Loebel, D., Tam, P. (2014). Differential response of epiblast stem cells to Nodal and Activin signalling: A paradigm of early endoderm development in the embryo. Philosophical Transactions of the Royal Society B, 369(1657), 1-10. [More Information]
Ip, C., Fossat, N., Jones, V., Lamonerie, T., Tam, P. (2014). Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm. Development, 141(20), 3859-3867. [More Information]
Hamada, H., Tam, P. (2014). Mechanisms of left-right asymmetry and patterning: driver, mediator and responder. F1000 Prime Reports, 6, 1-9. [More Information]
Gold, W., Williamson, S., Kaur, S., Hargreaves, I., Land, J., Pelka, G., Tam, P., Christodoulou, J. (2014). Mitochondrial dysfunction in the skeletal muscle of a mouse model of Rett syndrome (RTT): Implications for the disease phenotype. Mitochondrion, 15, 10-17. [More Information]
Fossat, N., Tam, P. (2014). Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing. RNA Biology, 11(10), 1233-1237. [More Information]
Kojima, Y., Kaufman-Francis, K., Studdert, J., Steiner, K., Power, M., Loebel, D., Jones, V., Hor, A., de Alencastro, G., Logan, G., Alexander, I., Pickett, H., Tam, P., et al (2014). The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak. Cell Stem Cell, 14(1), 107-120. [More Information]
Loebel, D., Hor, A., Bildsoe, H., Tam, P. (2014). Timed Deletion of Twist1 in the Limb Bud Reveals Age-Specific Impacts on Autopod and Zeugopod Patterning. PloS One, 9(6), 1-9. [More Information]
Kojima, Y., Tam, O., Tam, P. (2014). Timing of developmental events in the early mouse embryo. Seminars in Cell & Developmental Biology, 34, 65-75. [More Information]
Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Development, 27(1), 18-23. [More Information]
Maxwell, S., Pelka, G., Tam, P., El-Osta, A. (2013). Chromatin context and ncRNA highlight targets of MeCP2 in brain. RNA Biology, 10(11), 1741-1757. [More Information]
Tanaka, S., Nakane, A., Yamaguchi, Y., Terabayashi, T., Abe, T., Nakao, K., Asashima, M., Steiner, K., Tam, P., Nishinakamura, R. (2013). Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo. PloS One, 8(3), 1-14. [More Information]
Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
Tam, P., Pera, M. (2013). Stem cell science and regenerative medicine. BioEssays, 35(3), 147-148. [More Information]
Bildsoe, H., Loebel, D., Jones, V., Hor, A., Braithwaite, A., Chen, Y., Behringer, R., Tam, P. (2013). The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss fof Twist1 function. Developmental Biology, 374(2), 295-307. [More Information]
Ng, H., Tam, P. (2013). The mystique of cellular reprogramming. Current Opinion in Genetics & Development, 23(5), 501-503. [More Information]
Arkell, R., Fossat, N., Tam, P. (2013). Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output. Current Opinion in Genetics & Development, 23(4), 454-460. [More Information]
Williamson, S., Giudici, L., Kilstrup-Nielsen, C., Gold, W., Pelka, G., Tam, P., Grimm, A., Prodi, D., Landsberger, N., Christodoulou, J. (2012). A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain. Human Genetics, 131(2), 187-200. [More Information]
Arkell, R., Tam, P. (2012). Initiating head development in mouse embryos: integrating signalling and transcriptional activity. Open Biology, 2(March 2012), 1-10. [More Information]
Stephenson, R., Rossant, J., Tam, P. (2012). Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. Cold Spring Harbor Perspectives in Biology, 4(11), 1-15. [More Information]
Fossat, N., Jones, V., Garcia-Garcia, M., Tam, P. (2012). Modulation of WNT signaling activity is key to the formation of the embryonic head. Cell Cycle, 11(1), 26-32. [More Information]
Loebel, D., Hor, A., Bildsoe, H., Jones, V., Chen, Y., Behringer, R., Tam, P. (2012). Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton. Developmental Biology, 362(2), 132-140. [More Information]
Loebel, D., Tam, P. (2012). Rho GTPases in endoderm development and differentiation. Small GTPases, 3(1), 40-44. [More Information]
Coombes, A., Bowles, J., Feng, C., Chiu, H., Khoo, P., Jackson, A., Little, M., Tam, P., Koopman, P. (2011). Expression and functional analysis of Dkk1 during early gonadal development. Sexual Development, 5(3), 124-130. [More Information]
Tanaka, S., Kojima, Y., Yamaguchi, Y., Nishinakamura, R., Tam, P. (2011). Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo. Development, Growth and Differentiation, 53(7), 843-856. [More Information]
Loebel, D., Studdert, J., Power, M., Radziewic, T., Jones, V., Coultas, L., Jackson, Y., Rao, R., Steiner, K., Fossat, N., Tam, P., et al (2011). Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development, 138(20), 4511-4522. [More Information]
Pfister, S., Jones, V., Power, M., Truisi, G., Khoo, P., Steiner, K., Kanai-Azuma, M., Kanai, Y., Tam, P., Loebel, D. (2011). Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. International Journal of Developmental Biology, 55(1), 45-58. [More Information]
Fossat, N., Jones, V., Khoo, P., Bogani, D., Hardy, A., Steiner, K., Mukhopadhyay, M., Westphal, H., Nolan, P., Arkell, R., Tam, P. (2011). Stringent Requirement of a Proper Level of Canonical WNT Signalling Activity for Head Formation in Mouse Embryo. Development, 138(4), 667-676. [More Information]
Harikrishnan, K., Bayles, R., Ciccotosto, G., Maxwell, S., Cappai, R., Pelka, G., Tam, P., Christodoulou, J., El-Osta, A. (2010). Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons. Journal of Neuroscience, 30(4), 1494-1501. [More Information]
Pera, M., Tam, P. (2010). Extrinsic regulation of pluripotent stem cells. Nature, 465(7299), 713-720. [More Information]
Tanaka, S., Yamaguchi, Y., Steiner, K., Nakano, T., Nishinakamura, R., Kwan, K., Behringer, R., Tam, P. (2010). Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse. Developmental Dynamics, 239(11), 2851-2859. [More Information]
Leung, A., Wong, S., Chan, D., Tam, P., Cheah, K. (2010). Loss of Procollagen IIA From the Anterior Mesendoderm Disrupts the Development of Mouse Embryonic Forebrain. Developmental Dynamics, 239(9), 2319-2329. [More Information]
Fath, T., Chan, Y., Vrhovski, B., Clarke, H., Curthoys, N., Hook, J., Lemckert, F., Schevzov, G., Tam, P., Watson, C., Gunning, P., et al (2010). New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2. European Journal of Cell Biology, 89(7), 489-498. [More Information]
Weaving, L., Mihelec, M., Storen, R., Sosic, D., Grigg, J., Tam, P., Jamieson, R. (2010). Twist2: Role in Corneal Stromal Keratocyte Proliferation and Corneal Thickness. Investigative Ophthalmology and Visual Science, 51(11), 5561-5570. [More Information]
Rossant, J., Tam, P. (2009). Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development, 136(5), 701-713. [More Information]
Mihelec, M., Abraham, P., Gibson, K., Krowka, R., Susman, R., Storen, R., Chen, Y., Donald, J., Tam, P., Flaherty, M., Grigg, J., Jamieson, R., et al (2009). Novel SOX2 partner-factor domain mutation in a four-generation family. European Journal of Human Genetics, 17(11), 1417-1422. [More Information]
Bildsoe, H., Loebel, D., Jones, V., Chen, Y., Behringer, R., Tam, P. (2009). Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Developmental Biology, 331(2), 176-188. [More Information]
Tam, P., Loebel, D. (2009). Specifying mouse embryonic germ cells. Cell, 137(3), 398-400. [More Information]
Grassinger, J., Haylock, D., Storan, M., Haines, G., Williams, B., Whitty, G., Vinson, A., Be, C., Li, S., Tam, P. (2009). Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with Î±9Î²1 and Î±4Î²1 integrins. Blood, 114(1), 49-59. [More Information]
Watson, C., Trainor, P., Radziewic, T., Pelka, G., Zong, Z., Parameswaran, M., Quinlan, G., Gordon, M., Sturm, K., Tam, P., et al (2008). Application of lacZ Transgenic Mice to Cell Lineage Studies. Methods in Molecular Biology, 461, 149-164. [More Information]
Furtado, M., Solloway, M., Jones, V., Costa, M., Biben, C., Wolstein, O., Preis, J., Sparrow, D., Saga, Y., Dunwoodie, S., et al (2008). BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes and Development, 22, 3037-3049. [More Information]
Quinlan, G., Khoo, P., Wong, N., Trainor, P., Tam, P. (2008). Cell grafting and labeling in postimplantation mouse embryos. Methods in Molecular Biology, 461, 47-70. [More Information]
Mihelec, M., St Heaps, L., Flaherty, M., Billson, F., Rudduck, C., Tam, P., Grigg, J., Peters, G., Jamieson, R. (2008). Chromosomal Rearrangements and Novel Genes in Disorders of Eye Development, Cataract and Glaucoma. Twin Research and Human Genetics, 11(4), 412-421. [More Information]
Lewis, S., Khoo, P., Young, A., Steiner, K., Willcock, C., Mukhopadhyay, M., Westphal, H., Jamieson, R., Robb, L., Tam, P. (2008). Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development, 135(10), 1791-1801. [More Information]
Kondo, M., Gray, L., Pelka, G., Christodoulou, J., Tam, P., Hannan, A. (2008). Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome - Mecp2 gene dosage effects and BDNF expression. European Journal of Neuroscience, 27(12), 3342-3350. [More Information]
Franklin, V., Khoo, P., Bildsoe, H., Wong, N., Lewis, S., Tam, P. (2008). Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo. Mechanisms of Development, 125(7), 587-600. [More Information]
Fossat, N., Pfister, S., Tam, P. (2007). A transcriptome landscape of mouse embryogenesis. Developmental Cell, 13(6), 761-762. [More Information]
Tam, P., Lovell-Badge, R. (2007). Anne McLaren 1927-2007. Cell, 130(2), 201-213. [More Information]
Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al (2007). Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More Information]
Franklin, V., Bildsoe, H., Tam, P. (2007). Fate-Mapping Technique: Grafting Fluorescent Cells into Gastrula-Stage Mouse Embryos at 7-7.5 Days Post-coitum. CSH protocols, 2007, 4892. [More Information]
Khoo, P., Franklin, V., Tam, P. (2007). Fate-Mapping Technique: Targeted Whole-Embryo Electroporation of DNA Constructs into the Germ Layers of Mouse Embryos 7-7.5 Days Post-coitum. CSH protocols, 2007, 4893. [More Information]
Bildsoe, H., Franklin, V., Tam, P. (2007). Fate-mapping technique: using carbocyanine dyes for vital labeling of cells in gastrula-stage mouse embryos cultured in vitro. CSH protocols, 2007, 4915. [More Information]
Pfister, S., Steiner, K., Tam, P. (2007). Gene expression pattern and progression of embryogenesis in the immediate post-implantation period of mouse development. Gene Expression Patterns, 7(5), 558-573. [More Information]
Tam, P., Loebel, D. (2007). Gene function in mouse embryogenesis: get set for gastrulation. Nature Reviews Genetics, 8(5), 368-381. [More Information]
Lewis, S., Khoo, P., De Young, R., Bildsoe, H., Wakamiya, M., Behringer, R., Mukhopadhyay, M., Westphal, H., Tam, P. (2007). Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mechanisms of Development, 124(2), 157-165. [More Information]
Tam, P., Khoo, P., Lewis, S., Bildsoe, H., Wong, N., Tsang, T., Gad, J., Robb, L. (2007). Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development, 134(2), 251-260. [More Information]
Tam, P., Loebel, D., Tanaka, S. (2006). Building the mouse gastrula: signals, asymmetry and lineages. Current Opinion In Genetics and Development, 16(4), 419-425. [More Information]
Willcock, C., Grigg, J., Wilson, M., Tam, P., Billson, F., Jamieson, R. (2006). Congenital iris ectropion as an indicator of variant aniridia. British Journal of Ophthalmology, 90(5), 658-659. [More Information]
Lewis, S., Tam, P. (2006). Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function. Developmental Dynamics, 235(9), 2315-2329. [More Information]
Nolen, L., Amor, D., Haywood, A., St. Heaps, L., Willcock, C., Mihelec, M., Tam, P., Billson, F., Grigg, J., Peters, G., Jamieson, R. (2006). Deletion at 14q22-23 indicates a contiguous gene syndrome comprising anophthalmia, pituitary hypoplasia, and ear anomalies. American Journal of Medical Genetics, Part A, 140(16), 1711-1718. [More Information]
Duffy, S., Steiner, K., Tam, P., Boyd, A. (2006). Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development. Gene Expression Patterns, 6(7), 719-723. [More Information]
Yamaguchi, Y., Tanaka, S., Kasa, M., Yasuda, K., Tam, P., Matsui, Y. (2006). Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells. Gene Expression Patterns, 6(6), 607-612. [More Information]
Pelka, G., Watson, C., Radziewic, T., Hayward, M., Lahooti, H., Christodoulou, J., Tam, P. (2006). Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain, 129(Pt 4), 887-898. [More Information]
Yamaguchi, Y., Tanaka, S., Yasuda, K., Matsui, Y., Tam, P. (2006). Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Developmental Biology, 297(2), 350-360. [More Information]
Loebel, D., Tsoi, B., Wong, N., Tam, P. (2005). A conserved noncoding intronic transcript at the mouse Dnm3 locus. Genomics. [More Information]
Loebel, D., Tam, P. (2005). A gut feeling. Nature Biotechnology, 23(12), 1491-1492. [More Information]
Pelka, G., Watson, C., Christodoulou, J., Tam, P. (2005). Distinct expression profiles of Mecp2 transcripts with different lengths of 3'UTR in the brain and visceral organs during mouse development. Genomics, 85(4), 441-452. [More Information]
Tanaka, S., Yamaguchi, Y., Tsoi, B., Lickert, H., Tam, P. (2005). IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Developmental Cell, 9(6), 745-756. [More Information]
Watson, C., Pelka, G., Radziewic, T., Shahbazian, M., Christodoulou, J., Williamson, S., Tam, P. (2005). Reduced proportion of Purkinje cells expressing paternally derived mutant Mecp2 308 allele in female mouse cerebellum is not due to a skewed primary pattern of X-chromosome inactivation. Human Molecular Genetics, 14(13), 1851-1861. [More Information]
Ding, H., Wu, X., Bostrom, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G., Soriano, P., Betsholtz, C., Tam, P., et al (2004). A Specific Requirement For PDGF-C In Palate Formation And PDGFR-Alpha Signaling. Nature Genetics, 36(10), 1111-1116. [More Information]
Tam, P. (2004). Embryonic Axes: The Long And Short Of It In The Mouse. Current Biology, 14(6), R239-R241. [More Information]
Rossant, J., Tam, P. (2004). Emerging Asymmetry And Embryonic Patterning In Early Mouse Development. Developmental Cell, 7(2), 155-164. [More Information]
Robb, L., Tam, P. (2004). Gastrula Organiser And Embryonic Patterning In The Mouse. Seminars in Cell and Developmental Biology, 15(5), 543-554. [More Information]
Weaving, L., Christodoulou, J., Williamson, S., Friend, K., McKenzie, O., Archer, H., Evans, J., Clarke, A., Pelka, G., Tam, P., Lahooti, H., Ellaway, C., Bennetts, B., Watson, C., et al (2004). Mutations Of Cdkl5 Cause A Severe Neurodevelopmental Disorder With Infantile Spasms And Mental Retardation. American Journal of Human Genetics, 75, 1079-1093. [More Information]
Tam, P., Khoo, P., Wong, N., Tsang, T., Behringer, R. (2004). Regionalization Of Cell Fates And Cell Movement In The Endoderm Of The Mouse Gastrula And The Impact Of Loss Of Lhx1(Lim1) Function. Developmental Biology, 274(1), 171-187. [More Information]
Tanaka, S., Nagamatsu, G., Tokitake, Y., Kasa, M., Tam, P., Matsui, Y. (2004). Regulation Of Expression Of Mouse Interferon-Induced Transmembrane Protein Like Gene-3, Ifitm3 (Mil-1, Fragilis), In Germ Cells. Developmental Dynamics, 230(4), 651-659. [More Information]
Ding, H., Schertzer, M., Wu, X., Gertsenstein, M., Selig, S., Kammori, M., Pourvali, R., Poon, S., Vulto, I., et al, Tam, P. (2004). Regulation Of Murine Telomere Length By Rtel: An Essential Gene Encoding A Helicase-Like Protein. Cell, 117(7), 873-886. [More Information]
Loebel, D., Tsoi, B., Wong, N., O'Rourke, M., Tam, P. (2004). Restricted Expression Of Etn-Related Sequences During Post-Implantation Mouse Development. Gene Expression Patterns, 4(4), 467-471. [More Information]
Hukriede, N., Tsang, T., Habas, R., Khoo, P., Steiner, K., Weeks, D., Tam, P., Dawid, I. (2003). Conserved requirement of Lim1 function for cell movements during gastrulation. Developmental Cell, 4(1), 83-94. [More Information]
Tam, P., Kanai-Azuma, M., Kanai, Y. (2003). Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Current Opinion In Genetics and Development, 13(4), 393-400. [More Information]
Loebel, D., Watson, C., De Young, R., Tam, P. (2003). Lineage choice and differentiation in mouse embryos and embryonic stem cells. Developmental Biology, 264(1), 1-14. [More Information]
Tam, P., Rossant, J. (2003). Mouse embryonic chimeras: tools for studying mammalian development. Development, 130, 6155-6163. [More Information]
Stone, L., Tan, S., Tam, P., Finger, T. (2002). Analysis of Cell Lineage Relationships in Taste Buds. Journal of Neuroscience, 22(11), 4522-4529. [More Information]
Kanai-Azuma, M., Kanai, Y., Gad, J., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P., et al (2002). Depletion of definitive gut endoderm in Sox17-null mutant mice. Development, 129(10), 2367-2379.
Ristevski, S., Tam, P., Hertzog, P., Kola, I. (2002). Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo. Mechanisms of Development, 116, 165-168. [More Information]
Tam, P. (2002). First mitotic division: getting it right at the start. Nature Cell Biology, 4(10), E232-E232. [More Information]
Loebel, D., O'Rourke, M., Steiner, K., Banyer, J., Tam, P. (2002). Isolation of Differentially Expressed Genes from Wild-Type and Twist Mutant Mouse Limb Buds. Genesis, 33(3), 103-113. [More Information]
Hart, A., Hartley, L., Sourris, K., Stadler, E., Li, R., Stanley, E., Tam, P., Elefanty, A., Robb, L. (2002). Mixl1 is required for axial mesendoderm morpogenesis and patterning in the murine embryo. Development, 129(15), 3597-3608.
Soo, K., O'Rourke, M., Khoo, P., Steiner, K., Wong, N., Behringer, R., Tam, P. (2002). Twist Function is Required for morphogenesis of the Cephalic Neural Tuve and the Differentiation of the Cranial Neura Crest Cells in the Mouse Embryo. Developmental Biology, 247(2), 251-270. [More Information]
O'Rourke, M., Tam, P. (2002). Twist Functions in mouse development. International Journal of Developmental Biology, 46(4), 401-413.
O'Rourke, M., Soo, K., Behringer, R., Hui, C., Tam, P. (2002). Twist plays an essential role in FGF and SHH Signal Transduction during Mouse Limb Development. Developmental Biology, 248(1), 143-156. [More Information]
Kinder, S., Tam, P., Loebel, D. (2001). Allocation and Early Differentiation of Cardiovascular Progenitors in the Mouse Embryo. Trends In Cardiovascular Medicine, 11, 177-183.
Tam, P., Hadjantonakis, A., Cox,, L., Nagy,, A. (2001). An X-linked GFP transgene reveals unexpected paternal X-Chromosome activity in trophoblastic Giant Cells of the Mouse Placenta. Genesis, 29, 133-140.
Tam, P., Watson,, C. (2001). Cell Lineage Determination in the Mouse. Cell Structure and Function, 26, 123-129.
Kinder, S., Tsang, T., Tam, P., Ang,, S., Behringer, R. (2001). Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3B activity. International Journal of Developmental Biology, 45, 347-355.
Tam, P., Ristevski, S., Kola,, I., Hertzog, P. (2001). Desrt, an AT-rich interaction domain family transcription factor gene, is an early marker for nephrogenic mesoderm and is expressed dynamically during mourse limb development. Mechanisms of Development, 104, 139-142.
Tam, P., So, C., Cheah, K. (2001). Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis. Osteoarthritis and Cartilage, 9.
Orford, J., Manglick, P., Cass, D., Tam, P. (2001). Mechanisms for the development of esophageal atresia. Journal of Pediatric Surgery, 36(7), 985-994. [More Information]
Tam, P., Kinder, S., Tsang, T., Gad, J., Behringer, R. (2001). Morphogenetic tissue movement and the establishment of body plan during development from blastocyst to gastrula in the mouse. BioEssays, 23, 508-517.
Tsang, T., Tam, P., Khoo,, P., Jamieson, R., Zhou,, S., Ang,, S., Behringer, R. (2001). The allocation and differentiation of mouse primordial germ cells. International Journal of Developmental Biology, 45, 549-555.
Kinder, S., Tsang, T., Tam, P., Wakamiya, M., Sasaki, H., Behringer, R., Nagy,, A. (2001). The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development, 128, 3623-3634.

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Conferences

Tanaka, S., Yamaguchi, Y., Tam, P. (2007). Experimental approaches to study gene function in whole mouse embryo and fetal ovary in vitro. 7th Transgenic Technology (TT) Meeting (TT2007), Netherlands: Springer-Verlag.

Other

Tam, P. (2011), Endoderm Formation: Not So Black and White Anymore. [More Information]

By Year

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2024

Clark, A., Goolam, M., Hanna, J., Long, K., Nicol, D., Petropoulos, S., Saitou, M., Tam, P., Wang, H. (2024). Human developmental biology – a global perspective. Development, 151(17), dev203092. [More Information]
McMahon, R., Masamsetti, V., Tam, P. (2024). Phenotypic Analysis of Early Neurogenesis in a Mouse Chimeric Embryo and Stem Cell-Based Neuruloid Model. Methods in Molecular Biology, 2746, 165-177. [More Information]
Wu, Z., Zhao, Q., Kim, D., Yang, P., Hill, T., Jones, A., Fairlie, D., Pébay, A., Hewitt, A., Tam, P., et al (2024). Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Developmental Cell, 59(6), 705-722.e8. [More Information]

2023

Wang, R., Peng, G., Tam, P., Jing, N. (2023). Integration of Computational Analysis and Spatial Transcriptomics in Single-cell Studies. Genomics Proteomics and Bioinformatics, 21(1), 13-23. [More Information]
Newman, P., Yip, Q., Osteil, P., Anderson, T., Sun, J., Kempe, D., Biro, M., Shin, J., Tam, P., Zreiqat, H. (2023). Programming of Multicellular Patterning with Mechano-Chemically Microstructured Cell Niches. Advanced Science. [More Information]
Rugg-Gunn, P., Moris, N., Tam, P. (2023). Technical challenges of studying early human development. Development, 150(11). [More Information]
Wang, R., Yang, X., Chen, J., Zhang, L., Griffiths, J., Cui, G., Chen, Y., Qian, Y., Peng, G., Li, J., Tam, P., et al (2023). Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nature Communications, 14(1). [More Information]

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2022

Knowles, H., Santucci, N., Studdert, J., Goh, H., Kaufman-Francis, K., Salehin, N., Tam, P., Osteil, P. (2022). Differential impact of TGFÎ²/SMAD signaling activity elicited by Activin A and Nodal on endoderm differentiation of epiblast stem cells. Genesis, 60(1-Feb), e23466. [More Information]
Rossant, J., Tam, P. (2022). Early human embryonic development: Blastocyst formation to gastrulation. Developmental Cell, 57(2), 152-165. [More Information]
Salehin, N., Santucci, N., Osteil, P., Tam, P. (2022). Exploring Chromatin Accessibility in Mouse Epiblast Stem Cells with ATAC-Seq. Methods in Molecular Biology, 2490, 93-100. [More Information]
Tsang, T., Finlay-Jones, A., Perry, K., Grigg, J., Popova, S., Cheung, M., Bower, C., Tam, P., Jamieson, R., Elliott, E. (2022). Eye Abnormalities in Children with Fetal Alcohol Spectrum Disorders: A Systematic Review. Ophthalmic Epidemiology. [More Information]
Osteil, P., Studdert, J., Tam, P. (2022). Grafting of Epiblast Stem Cell into the Epiblast and Whole-Embryo Imaging to Unveil Lineage Competence. Methods in Molecular Biology, 2490, 269-279. [More Information]
Masamsetti, V., Tam, P. (2022). Identification and Visualization of Protein Expression in Whole Mouse Embryos by Immunofluorescence. Methods in Molecular Biology, 2490, 39-45. [More Information]
McMahon, R., Sibbritt, T., Aryamanesh, N., Masamsetti, V., Tam, P. (2022). Loss of Foxd4 Impacts Neurulation and Cranial Neural Crest Specification During Early Head Development. Frontiers in Cell and Developmental Biology, 9, 777652. [More Information]
Salehin, N., Knowles, H., Masamsetti, V., Tam, P. (2022). Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation. Biochemical Society Transactions, 50(6), 1619-1631. [More Information]
Haase, F., Singh, R., Gloss, B., Tam, P., Gold, W. (2022). Meta-Analysis Identifies BDNF and Novel Common Genes Differently Altered in Cross-Species Models of Rett Syndrome. International Journal of Molecular Sciences, 23(19). [More Information]
Yang, P., Tam, P. (2022). Mouse organogenesis atlas at single-cell resolution. Cell, 185(10), 1625-1627. [More Information]
Peng, G., Tam, P. (2022). Profiling spatial gene activity in marmoset embryos. Cell Research, 32(10), 873-874. [More Information]
Cui, G., Feng, S., Yan, Y., Wang, L., He, X., Li, X., Duan, Y., Chen, J., Tang, K., Zheng, P., Tam, P., et al (2022). Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo. Cell Reports, 40(9). [More Information]

show 9 more

2021

Nim, H., Dang, L., Thiyagarajah, H., Bakopoulos, D., See, M., Charitakis, N., Sibbritt, T., Eichenlaub, M., Archer, S., Fossat, N., Tam, P., et al (2021). A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease. Genome Biology, 22(1), 1-21. [More Information]
Kim, H., Tam, P., Yang, P. (2021). Defining cell identity beyond the premise of differential gene expression. Cell Regeneration, 10(1), 20-3 pages. [More Information]
Rossant, J., Tam, P. (2021). Opportunities and challenges with stem cell-based embryo models. Stem Cell Reports, 16(5), 1031-1038. [More Information]
Haase, F., Coorey, B., Riley, L., Cantrill, L., Tam, P., Gold, W. (2021). Pre-clinical Investigation of Rett Syndrome Using Human Stem Cell-Based Disease Models. Frontiers in Neuroscience, 15, 698812. [More Information]
Fan, X., Masamsetti, V., Sun, J., Engholm-Keller, K., Osteil, P., Studdert, J., Graham, M., Fossat, N., Tam, P. (2021). TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. eLife, 10, e62873-1-e62873-33. [More Information]
Kim, H., Wang, K., Chen, C., Lin, Y., Tam, P., Lin, D., Yang, J., Yang, P. (2021). Uncovering cell identity through differential stability with Cepo. Nature Computational Science, 1(12), 784-790. [More Information]
Haase, F., Gloss, B., Tam, P., Gold, W. (2021). Wgcna identifies translational and proteasome-ubiquitin dysfunction in rett syndrome. International Journal of Molecular Sciences, 22(18), 9954. [More Information]

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2020

Peng, G., Suo, S., Cui, G., Yu, F., Wang, R., Chen, J., Chen, S., Liu, Z., Chen, G., Qian, Y., Tam, P., et al (2020). Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature, 577(7791), E6. [More Information]
Tam, P., Ho, J. (2020). Cellular diversity and lineage trajectory: insights from mouse single cell transcriptomes. Development, 147(2), dev179788. [More Information]
Shim, W., Sinniah, E., Xu, J., Vitrinel, B., Alexanian, M., Andreoletti, G., Shen, S., Sun, Y., Balderson, B., Boix, C., Tam, P., et al (2020). Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity. Cell Systems, 11(6), 625-639.e13. [More Information]
Hamada, H., Tam, P. (2020). Diversity of left-right symmetry breaking strategy in animals. F1000Research, 9, 123. [More Information]
Salehin, N., Tam, P., Osteil, P. (2020). Prenet: Predictive network from ATAC-SEQ data. Journal of Bioinformatics and Computational Biology, 18(1), 2040003. [More Information]
Kim, H., Osteil, P., Humphrey, S., Cinghu, S., Oldfield, A., Patrick, E., Wilkie, E., Peng, G., Suo, S., Jothi, R., Tam, P., Yang, P. (2020). Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning. Nucleic Acids Research, 48(4), 1828-1842. [More Information]
Fan, X., Waardenberg, A., Demuth, M., Osteil, P., Sun, J., Loebel, D., Graham, M., Tam, P., Fossat, N. (2020). Twist1 homodimers and heterodimers orchestrate lineage-specific differentiation. Molecular and Cellular Biology, 40(11), 1-20. [More Information]

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2019

Osteil, P., Studdert, J., Goh, H., Wilkie, E., Fan, X., Khoo, P., Peng, G., Salehin, N., Knowles, H., Han, J., Fossat, N., Tam, P., et al (2019). Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells. Development, 146(7), 1-14. [More Information]
Gao, X., Nowak-Imialek, M., Chen, X., Chen, D., Herrmann, D., Ruan, D., Chen, A., Eckersley-Maslin, M., Ahmad, S., Lee, Y., Tam, P., et al (2019). Establishment of porcine and human expanded potential stem cells. Nature Cell Biology, 21(6), 687-699. [More Information]
Sibbritt, T., Osteil, P., Fan, X., Sun, J., Salehin, N., Knowles, H., Shen, J., Tam, P. (2019). Gene Editing of Mouse Embryonic and Epiblast Stem Cells. In Ivan Bertoncello (Eds.), Mouse Cell Culture: Methods and Protocols, (pp. 77-95). New York: Springer. [More Information]
McMahon, R., Sibbritt, T., Salehin, N., Osteil, P., Tam, P. (2019). Mechanistic insights from the LHX1-driven molecular network in building the embryonic head. Development, Growth and Differentiation, 61(5), 327-336. [More Information]
Tam, P. (2019). Modeling the early development of a primate embryo. Science, 366(6467), 798-799. [More Information]
Peng, G., Suo, S., Cui, G., Yu, F., Wang, R., Chen, J., Chen, S., Liu, Z., Chen, G., Qian, Y., Tam, P., et al (2019). Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature, 572, 528-532. [More Information]
Cheng, S., Pei, Y., He, L., Peng, G., Reinius, B., Tam, P., Jing, N., Deng, Q. (2019). Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development. Cell Reports, 26(10), 2593-2607.e3. [More Information]
Humphreys, D., Fossat, N., Demuth, M., Tam, P., Ho, J. (2019). Ularcirc: visualization and enhanced analysis of circular RNAs via back and canonical forward splicing. Nucleic Acids Research, 47(20), 1-17. [More Information]

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2018

Sibbritt, T., Ip, C., Khoo, P., Wilkie, E., Jones, V., Sun, J., Shen, J., Peng, G., Han, J., Jing, N., Osteil, P., Tam, P., Fossat, N., et al (2018). A gene regulatory network anchored by LIM homeobox 1 for embryonic head development. Genesis, 56(9), 1-13. [More Information]
Rossant, J., Tam, P. (2018). Exploring early human embryo development. Science, 360(6393), 1075-1076. [More Information]
McDonald, M., Morse, A., Schindeler, A., Mikulec, K., Peacock, L., Cheng, T., Bobyn, J., Lee, L., Baldock, P., Croucher, P., Tam, P., Little, D. (2018). Homozygous Dkk1 Knockout Mice Exhibit High Bone Mass Phenotype Due to Increased Bone Formation. Calcified Tissue International, 102(1), 105-116. [More Information]
Cui, G., Suo, S., Wang, R., Qian, Y., Han, J., Peng, G., Tam, P., Jing, N. (2018). Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Development, Growth and Differentiation, 60(8), 463-472. [More Information]
Yu, Z., Tang, P., Wang, J., Bao, S., Shieh, J., Leung, A., Zhang, Z., Gao, F., Wong, S., Hui, A., Tam, P. (2018). Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight, 3(2), 1-21. [More Information]
Friedman, C., Nguyen, Q., Lukowski, S., Helfer, A., Chiu, H., Miklas, J., Levy, S., Suo, S., Han, J., Osteil, P., Tam, P., et al (2018). Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation. Cell Stem Cell, 23(4), 586-598. [More Information]
Liu, C., Wang, R., He, Z., Osteil, P., Wilkie, E., Yang, X., Chen, J., Cui, G., Guo, W., Chen, Y., Tam, P., et al (2018). Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells. Stem Cell Reports, 11(1), 43-57. [More Information]

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2017

Yang, J., Ryan, D., Wang, W., Tsang, J., Lan, G., Masaki, H., Gao, X., Antunes, L., Yu, Y., Tam, P., et al (2017). Establishment of mouse expanded potential stem cells. Nature, 550(7676), 393-397. [More Information]
Logan, G., Dane, A., Hallwirth, C., Smyth, C., Wilkie, E., Amaya, A., Zhu, E., Khandekar, N., Ginn, S., Liao, S., Cunningham, S., Sasaki, N., Cabanes Creus, M., Tam, P., Lisowski, L., Alexander, I., et al (2017). Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome. Nature Genetics, 49(8), 1267-1273. [More Information]
Fatima, S., Wagstaff, K., Lieu, K., Davies, R., Tanaka, S., Yamaguchi, Y., Loveland, K., Tam, P., Jans, D. (2017). Interactome of the inhibitory isoform of the nuclear transporter Importin 13. Biochimica et Biophysica Acta, 1864 (3), 546-561. [More Information]
Peng, G., Tam, P., Jing, N. (2017). Lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies. National Science Review, 4(4), 533-542. [More Information]
Rossant, J., Tam, P. (2017). New insights into early human development: lessons for stem cell derivation and differentiation. Cell Stem Cell, 20(1), 18-28. [More Information]
Zamir, L., Singh, R., Nathan, E., Patrick, R., Yifa, O., Yahalom-Ronen, Y., Arraf, A., Schultheiss, T., Suo, S., Han, J., Tam, P., et al (2017). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta. eLife, 6, 1-31. [More Information]
Savatier, P., Osteil, P., Tam, P. (2017). Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff. Stem Cell Research, 19, 104-112. [More Information]
Chiang, I., Fritzsche, M., Thievend, C., Neal, A., Holmes, K., Lagendijk, A., Overman, J., D'Angelo, D., Omini, A., Tam, P. (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144(20), 3847-3848. [More Information]
Chen, J., Suo, S., Tam, P., Han, J., Peng, G., Jing, N. (2017). Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nature Protocols, 12(3), 566-580. [More Information]

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2016

Zheng, G., Zhang, J., Zhao, H., Wang, H., Pang, M., Qiao, X., Lee, S., Hsu, T., Tan, T., Lyons, J., Zhao, Y., Loebel, D., Wang, Y., Wang, Y., Wang, Y., Cao, Q., Wang, C., Lee, V., Tam, P., Harris, D., et al (2016). a3 Integrin of Cell-Cell Contact Mediates Kidney Fibrosis by Integrin-Linked Kinase in Proximal Tubular E-Cadherin Deficient Mice. American Journal of Pathology, 186(7), 1847-1860. [More Information]
Kondo, M., Gray, L., Pelka, G., Leang, S., Christodoulou, J., Tam, P., Hannan, A. (2016). Affective dysfunction in a mouse model of Rett syndrome: Therapeutic effects of environmental stimulation and physical activity. Developmental Neurobiology, 76(2), 209-224. [More Information]
Fossat, N., Radziewic, T., Jones, V., Tourle, K., Tam, P. (2016). Conditional restoration and inactivation of Rbm47 reveal its tissue-context requirement for viability and growth. Genesis, 54(3), 115-122. [More Information]
Bildsoe, H., Fan, X., Wilkie, E., Ashoti, A., Jones, V., Power, M., Qin, J., Wang, J., Tam, P., Loebel, D. (2016). Dataset of TWIST1-regulated genes in the cranial mesoderm and a transcriptome comparison of cranial mesoderm and cranial neural crest. Data in Brief, 9, 372-375. [More Information]
Tam, P., Fossat, N., Wilkie, E., Loebel, D., Ip, C., Ramialison, M. (2016). Formation of the Embryonic Head in the Mouse: Attributes of a Gene Regulatory Network. Current Topics in Developmental Biology, 117, 497-521. [More Information]
Osteil, P., Studdert, J., Wilkie, E., Fossat, N., Tam, P. (2016). Generation of genome-edited mouse epiblast stem cells via a detour through ES cell-chimeras. Differentiation, 91(45), 119-125. [More Information]
Tam, P. (2016). Human Stem Cells Can Differentiate in Post-implantation Mouse Embryos. Cell Stem Cell, 18(1), 3-4. [More Information]
Peng, G., Suo, S., Chen, J., Chen, W., Liu, C., Yu, F., Wang, R., Chen, S., Sun, N., Cui, G., Tam, P., et al (2016). Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell, 36(6), 681-697. [More Information]
Loebel, D., Plageman, T., Tang, T., Jones, V., Muccioli, M., Tam, P. (2016). Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction. Biology Open, 5(2), 130-139. [More Information]
Bildsoe, H., Fan, X., Wilkie, E., Ashoti, A., Jones, V., Power, M., Qin, J., Wang, J., Tam, P., Loebel, D. (2016). Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Developmental Biology, 418(1), 189-203. [More Information]

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2015

McShane, S., Mole, M., Savery, D., Greene, N., Tam, P., Copp, A. (2015). Cellular basis of neuroepithelial bending during mouse spinal neural tube closure. Developmental Biology, 404(2), 113-124. [More Information]
Fossat, N., Ip, C., Jones, V., Studdert, J., Khoo, P., Lewis, S., Power, M., Tourle, K., Loebel, D., Kwan, K., Tam, P., et al (2015). Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development, 142(11), 2069-2079. [More Information]
Williamson, S., Ellaway, C., Peters, G., Pelka, G., Tam, P., Christodoulou, J. (2015). Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype. European Journal of Human Genetics, 23(9), 1171-1175. [More Information]
Greenlees, R., Mihelec, M., Yousoof, S., Speidel, D., Wu, S., Rinkwitz, S., Prokudin, I., Perveen, R., Cheng, A., Ma, A., Nash, B., Loebel, D., Grigg, J., Tam, P., Becker, T., Jamieson, R., et al (2015). Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization. Human Molecular Genetics, 24(20), 5789-5804. [More Information]
Pera, M., de Wert, G., Dondorp, W., Lovell-Badge, R., Mummery, C., Munsie, M., Tam, P. (2015). What if stem cells turn into embryos in a dish? Nature Methods, 12(10), 917-919. [More Information]

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2014

Tanaka, S., Yamaguchi, Y., Jones, V., Tam, P. (2014). Analyzing gene function in whole mouse embryo and fetal organ in vitro. In Mark Lewandoski (Eds.), Mouse Molecular Embryology: Methods and Protocols, (pp. 367-393). New York: Humana Press. [More Information]
Fossat, N., Tourle, K., Radziewic, T., Barratt, K., Liebhold, D., Studdert, J., Power, M., Jones, V., Loebel, D., Tam, P. (2014). C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. EMBO Reports, 15(8), 903-910. [More Information]
Kaufman-Francis, K., Goh, H., Kojima, Y., Studdert, J., Jones, V., Power, M., Wilkie, E., Teber, E., Loebel, D., Tam, P. (2014). Differential response of epiblast stem cells to Nodal and Activin signalling: A paradigm of early endoderm development in the embryo. Philosophical Transactions of the Royal Society B, 369(1657), 1-10. [More Information]
Loebel, D., Radziewic, T., Power, M., Studdert, J., Tam, P. (2014). Generation of mouse embryos with small hairpin RNA-mediated knockdown of gene expression. In Mark Lewandoski (Eds.), Mouse Molecular Embryology: Methods and Protocols, (pp. 119-142). New York: Humana Press. [More Information]
Ip, C., Fossat, N., Jones, V., Lamonerie, T., Tam, P. (2014). Head formation: OTX2 regulates Dkk1 and Lhx1 activity in the anterior mesendoderm. Development, 141(20), 3859-3867. [More Information]
Hamada, H., Tam, P. (2014). Mechanisms of left-right asymmetry and patterning: driver, mediator and responder. F1000 Prime Reports, 6, 1-9. [More Information]
Gold, W., Williamson, S., Kaur, S., Hargreaves, I., Land, J., Pelka, G., Tam, P., Christodoulou, J. (2014). Mitochondrial dysfunction in the skeletal muscle of a mouse model of Rett syndrome (RTT): Implications for the disease phenotype. Mitochondrion, 15, 10-17. [More Information]
Fossat, N., Tam, P. (2014). Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing. RNA Biology, 11(10), 1233-1237. [More Information]
Kojima, Y., Kaufman-Francis, K., Studdert, J., Steiner, K., Power, M., Loebel, D., Jones, V., Hor, A., de Alencastro, G., Logan, G., Alexander, I., Pickett, H., Tam, P., et al (2014). The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak. Cell Stem Cell, 14(1), 107-120. [More Information]
Loebel, D., Hor, A., Bildsoe, H., Tam, P. (2014). Timed Deletion of Twist1 in the Limb Bud Reveals Age-Specific Impacts on Autopod and Zeugopod Patterning. PloS One, 9(6), 1-9. [More Information]
Kojima, Y., Tam, O., Tam, P. (2014). Timing of developmental events in the early mouse embryo. Seminars in Cell & Developmental Biology, 34, 65-75. [More Information]

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2013

Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Development, 27(1), 18-23. [More Information]
Maxwell, S., Pelka, G., Tam, P., El-Osta, A. (2013). Chromatin context and ncRNA highlight targets of MeCP2 in brain. RNA Biology, 10(11), 1741-1757. [More Information]
Tanaka, S., Nakane, A., Yamaguchi, Y., Terabayashi, T., Abe, T., Nakao, K., Asashima, M., Steiner, K., Tam, P., Nishinakamura, R. (2013). Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo. PloS One, 8(3), 1-14. [More Information]
Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
Tam, P., Nelson, W., Rossant, J. (2013). Mammalian Development: Networks, Switches, and Morphogenetic Processes. New York: Cold Spring Harbor Laboratory Press.
Stephenson, R., Rossant, J., Tam, P. (2013). Reprint: Intercellular Interactions, Position, and Polarity in Establishing Blastocyst Cell Lineages. In Patrick P. L. Tam, W. James Nelson, Janet Rossant (Eds.), Mammalian Development: Networks, Switches, and Morphogenetic Processes, (pp. 167-182). New York: Cold Spring Harbor Laboratory Press.
Tam, P., Pera, M. (2013). Stem cell science and regenerative medicine. BioEssays, 35(3), 147-148. [More Information]
Bildsoe, H., Loebel, D., Jones, V., Hor, A., Braithwaite, A., Chen, Y., Behringer, R., Tam, P. (2013). The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss fof Twist1 function. Developmental Biology, 374(2), 295-307. [More Information]
Ng, H., Tam, P. (2013). The mystique of cellular reprogramming. Current Opinion in Genetics & Development, 23(5), 501-503. [More Information]
Arkell, R., Fossat, N., Tam, P. (2013). Wnt signalling in mouse gastrulation and anterior development: new players in the pathway and signal output. Current Opinion in Genetics & Development, 23(4), 454-460. [More Information]

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2012

Williamson, S., Giudici, L., Kilstrup-Nielsen, C., Gold, W., Pelka, G., Tam, P., Grimm, A., Prodi, D., Landsberger, N., Christodoulou, J. (2012). A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain. Human Genetics, 131(2), 187-200. [More Information]
Arkell, R., Tam, P. (2012). Initiating head development in mouse embryos: integrating signalling and transcriptional activity. Open Biology, 2(March 2012), 1-10. [More Information]
Stephenson, R., Rossant, J., Tam, P. (2012). Intercellular interactions, position, and polarity in establishing blastocyst cell lineages and embryonic axes. Cold Spring Harbor Perspectives in Biology, 4(11), 1-15. [More Information]
Fossat, N., Jones, V., Garcia-Garcia, M., Tam, P. (2012). Modulation of WNT signaling activity is key to the formation of the embryonic head. Cell Cycle, 11(1), 26-32. [More Information]
Loebel, D., Hor, A., Bildsoe, H., Jones, V., Chen, Y., Behringer, R., Tam, P. (2012). Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton. Developmental Biology, 362(2), 132-140. [More Information]
Loebel, D., Tam, P. (2012). Rho GTPases in endoderm development and differentiation. Small GTPases, 3(1), 40-44. [More Information]

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2011

Tam, P. (2011), Endoderm Formation: Not So Black and White Anymore. [More Information]
Coombes, A., Bowles, J., Feng, C., Chiu, H., Khoo, P., Jackson, A., Little, M., Tam, P., Koopman, P. (2011). Expression and functional analysis of Dkk1 during early gonadal development. Sexual Development, 5(3), 124-130. [More Information]
Tanaka, S., Kojima, Y., Yamaguchi, Y., Nishinakamura, R., Tam, P. (2011). Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo. Development, Growth and Differentiation, 53(7), 843-856. [More Information]
Fossat, N., Loebel, D., Jones, V., Khoo, P., Bildsoe, H., Tam, P. (2011). Marking Cells for Imaging Analysis of Morphogenetic Behavior and Cell Fates in Mouse Embryos. In James Sharpe, Rachel Wong (Eds.), Imaging in Developmental Biology: A Laboratory Manual, (pp. 311-329). Woodbury, New York, USA: Cold Spring Harbor Laboratory Press.
Loebel, D., Studdert, J., Power, M., Radziewic, T., Jones, V., Coultas, L., Jackson, Y., Rao, R., Steiner, K., Fossat, N., Tam, P., et al (2011). Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm. Development, 138(20), 4511-4522. [More Information]
Pfister, S., Jones, V., Power, M., Truisi, G., Khoo, P., Steiner, K., Kanai-Azuma, M., Kanai, Y., Tam, P., Loebel, D. (2011). Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. International Journal of Developmental Biology, 55(1), 45-58. [More Information]
Fossat, N., Jones, V., Khoo, P., Bogani, D., Hardy, A., Steiner, K., Mukhopadhyay, M., Westphal, H., Nolan, P., Arkell, R., Tam, P. (2011). Stringent Requirement of a Proper Level of Canonical WNT Signalling Activity for Head Formation in Mouse Embryo. Development, 138(4), 667-676. [More Information]

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2010

Harikrishnan, K., Bayles, R., Ciccotosto, G., Maxwell, S., Cappai, R., Pelka, G., Tam, P., Christodoulou, J., El-Osta, A. (2010). Alleviating Transcriptional Inhibition of the Norepinephrine Slc6a2 Transporter Gene in Depolarized Neurons. Journal of Neuroscience, 30(4), 1494-1501. [More Information]
Rivera-Perez, J., Jones, V., Tam, P. (2010). Culture of Whole Mouse Embryos at Early Postimplantation to Organogenesis Stages: Developmental Staging and Methods. In Paul M. Wassarman and Philippe M. Soriano (Eds.), Methods in Enzymology Volume 476: Guide to Techniques in Mouse Development, Part A: Mice, Embryos, and Cells, (pp. 185-203). United States: Elsevier. [More Information]
Pera, M., Tam, P. (2010). Extrinsic regulation of pluripotent stem cells. Nature, 465(7299), 713-720. [More Information]
Tanaka, S., Yamaguchi, Y., Steiner, K., Nakano, T., Nishinakamura, R., Kwan, K., Behringer, R., Tam, P. (2010). Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse. Developmental Dynamics, 239(11), 2851-2859. [More Information]
Leung, A., Wong, S., Chan, D., Tam, P., Cheah, K. (2010). Loss of Procollagen IIA From the Anterior Mesendoderm Disrupts the Development of Mouse Embryonic Forebrain. Developmental Dynamics, 239(9), 2319-2329. [More Information]
Fath, T., Chan, Y., Vrhovski, B., Clarke, H., Curthoys, N., Hook, J., Lemckert, F., Schevzov, G., Tam, P., Watson, C., Gunning, P., et al (2010). New aspects of tropomyosin-regulated neuritogenesis revealed by the deletion of Tm5NM1 and 2. European Journal of Cell Biology, 89(7), 489-498. [More Information]
Weaving, L., Mihelec, M., Storen, R., Sosic, D., Grigg, J., Tam, P., Jamieson, R. (2010). Twist2: Role in Corneal Stromal Keratocyte Proliferation and Corneal Thickness. Investigative Ophthalmology and Visual Science, 51(11), 5561-5570. [More Information]

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2009

Rossant, J., Tam, P. (2009). Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development, 136(5), 701-713. [More Information]
Mihelec, M., Abraham, P., Gibson, K., Krowka, R., Susman, R., Storen, R., Chen, Y., Donald, J., Tam, P., Flaherty, M., Grigg, J., Jamieson, R., et al (2009). Novel SOX2 partner-factor domain mutation in a four-generation family. European Journal of Human Genetics, 17(11), 1417-1422. [More Information]
Bildsoe, H., Loebel, D., Jones, V., Chen, Y., Behringer, R., Tam, P. (2009). Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Developmental Biology, 331(2), 176-188. [More Information]
Tam, P., Loebel, D. (2009). Specifying mouse embryonic germ cells. Cell, 137(3), 398-400. [More Information]
Grassinger, J., Haylock, D., Storan, M., Haines, G., Williams, B., Whitty, G., Vinson, A., Be, C., Li, S., Tam, P. (2009). Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with Î±9Î²1 and Î±4Î²1 integrins. Blood, 114(1), 49-59. [More Information]

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2008

Watson, C., Trainor, P., Radziewic, T., Pelka, G., Zong, Z., Parameswaran, M., Quinlan, G., Gordon, M., Sturm, K., Tam, P., et al (2008). Application of lacZ Transgenic Mice to Cell Lineage Studies. Methods in Molecular Biology, 461, 149-164. [More Information]
Furtado, M., Solloway, M., Jones, V., Costa, M., Biben, C., Wolstein, O., Preis, J., Sparrow, D., Saga, Y., Dunwoodie, S., et al (2008). BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes and Development, 22, 3037-3049. [More Information]
Quinlan, G., Khoo, P., Wong, N., Trainor, P., Tam, P. (2008). Cell grafting and labeling in postimplantation mouse embryos. Methods in Molecular Biology, 461, 47-70. [More Information]
Mihelec, M., St Heaps, L., Flaherty, M., Billson, F., Rudduck, C., Tam, P., Grigg, J., Peters, G., Jamieson, R. (2008). Chromosomal Rearrangements and Novel Genes in Disorders of Eye Development, Cataract and Glaucoma. Twin Research and Human Genetics, 11(4), 412-421. [More Information]
Lewis, S., Khoo, P., Young, A., Steiner, K., Willcock, C., Mukhopadhyay, M., Westphal, H., Jamieson, R., Robb, L., Tam, P. (2008). Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development, 135(10), 1791-1801. [More Information]
Kondo, M., Gray, L., Pelka, G., Christodoulou, J., Tam, P., Hannan, A. (2008). Environmental enrichment ameliorates a motor coordination deficit in a mouse model of Rett syndrome - Mecp2 gene dosage effects and BDNF expression. European Journal of Neuroscience, 27(12), 3342-3350. [More Information]
Franklin, V., Khoo, P., Bildsoe, H., Wong, N., Lewis, S., Tam, P. (2008). Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo. Mechanisms of Development, 125(7), 587-600. [More Information]

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2007

Fossat, N., Pfister, S., Tam, P. (2007). A transcriptome landscape of mouse embryogenesis. Developmental Cell, 13(6), 761-762. [More Information]
Tam, P., Lovell-Badge, R. (2007). Anne McLaren 1927-2007. Cell, 130(2), 201-213. [More Information]
Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al (2007). Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More Information]
Tanaka, S., Yamaguchi, Y., Tam, P. (2007). Experimental approaches to study gene function in whole mouse embryo and fetal ovary in vitro. 7th Transgenic Technology (TT) Meeting (TT2007), Netherlands: Springer-Verlag.
Franklin, V., Bildsoe, H., Tam, P. (2007). Fate-Mapping Technique: Grafting Fluorescent Cells into Gastrula-Stage Mouse Embryos at 7-7.5 Days Post-coitum. CSH protocols, 2007, 4892. [More Information]
Khoo, P., Franklin, V., Tam, P. (2007). Fate-Mapping Technique: Targeted Whole-Embryo Electroporation of DNA Constructs into the Germ Layers of Mouse Embryos 7-7.5 Days Post-coitum. CSH protocols, 2007, 4893. [More Information]
Bildsoe, H., Franklin, V., Tam, P. (2007). Fate-mapping technique: using carbocyanine dyes for vital labeling of cells in gastrula-stage mouse embryos cultured in vitro. CSH protocols, 2007, 4915. [More Information]
Pfister, S., Steiner, K., Tam, P. (2007). Gene expression pattern and progression of embryogenesis in the immediate post-implantation period of mouse development. Gene Expression Patterns, 7(5), 558-573. [More Information]
Tam, P., Loebel, D. (2007). Gene function in mouse embryogenesis: get set for gastrulation. Nature Reviews Genetics, 8(5), 368-381. [More Information]
Lewis, S., Khoo, P., De Young, R., Bildsoe, H., Wakamiya, M., Behringer, R., Mukhopadhyay, M., Westphal, H., Tam, P. (2007). Genetic interaction of Gsc and Dkk1 in head morphogenesis of the mouse. Mechanisms of Development, 124(2), 157-165. [More Information]
Tam, P., Khoo, P., Lewis, S., Bildsoe, H., Wong, N., Tsang, T., Gad, J., Robb, L. (2007). Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation. Development, 134(2), 251-260. [More Information]

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2006

Tam, P., Loebel, D., Tanaka, S. (2006). Building the mouse gastrula: signals, asymmetry and lineages. Current Opinion In Genetics and Development, 16(4), 419-425. [More Information]
Willcock, C., Grigg, J., Wilson, M., Tam, P., Billson, F., Jamieson, R. (2006). Congenital iris ectropion as an indicator of variant aniridia. British Journal of Ophthalmology, 90(5), 658-659. [More Information]
Lewis, S., Tam, P. (2006). Definitive endoderm of the mouse embryo: Formation, cell fates, and morphogenetic function. Developmental Dynamics, 235(9), 2315-2329. [More Information]
Nolen, L., Amor, D., Haywood, A., St. Heaps, L., Willcock, C., Mihelec, M., Tam, P., Billson, F., Grigg, J., Peters, G., Jamieson, R. (2006). Deletion at 14q22-23 indicates a contiguous gene syndrome comprising anophthalmia, pituitary hypoplasia, and ear anomalies. American Journal of Medical Genetics, Part A, 140(16), 1711-1718. [More Information]
Duffy, S., Steiner, K., Tam, P., Boyd, A. (2006). Expression analysis of the Epha1 receptor tyrosine kinase and its high-affinity ligands Efna1 and Efna3 during early mouse development. Gene Expression Patterns, 6(7), 719-723. [More Information]
Yamaguchi, Y., Tanaka, S., Kasa, M., Yasuda, K., Tam, P., Matsui, Y. (2006). Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells. Gene Expression Patterns, 6(6), 607-612. [More Information]
Pelka, G., Watson, C., Radziewic, T., Hayward, M., Lahooti, H., Christodoulou, J., Tam, P. (2006). Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain, 129(Pt 4), 887-898. [More Information]
Yamaguchi, Y., Tanaka, S., Yasuda, K., Matsui, Y., Tam, P. (2006). Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Developmental Biology, 297(2), 350-360. [More Information]

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2005

Loebel, D., Tsoi, B., Wong, N., Tam, P. (2005). A conserved noncoding intronic transcript at the mouse Dnm3 locus. Genomics. [More Information]
Loebel, D., Tam, P. (2005). A gut feeling. Nature Biotechnology, 23(12), 1491-1492. [More Information]
Pelka, G., Watson, C., Christodoulou, J., Tam, P. (2005). Distinct expression profiles of Mecp2 transcripts with different lengths of 3'UTR in the brain and visceral organs during mouse development. Genomics, 85(4), 441-452. [More Information]
Tanaka, S., Yamaguchi, Y., Tsoi, B., Lickert, H., Tam, P. (2005). IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Developmental Cell, 9(6), 745-756. [More Information]
Watson, C., Pelka, G., Radziewic, T., Shahbazian, M., Christodoulou, J., Williamson, S., Tam, P. (2005). Reduced proportion of Purkinje cells expressing paternally derived mutant Mecp2 308 allele in female mouse cerebellum is not due to a skewed primary pattern of X-chromosome inactivation. Human Molecular Genetics, 14(13), 1851-1861. [More Information]

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2004

Ding, H., Wu, X., Bostrom, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G., Soriano, P., Betsholtz, C., Tam, P., et al (2004). A Specific Requirement For PDGF-C In Palate Formation And PDGFR-Alpha Signaling. Nature Genetics, 36(10), 1111-1116. [More Information]
Tam, P. (2004). Embryonic Axes: The Long And Short Of It In The Mouse. Current Biology, 14(6), R239-R241. [More Information]
Rossant, J., Tam, P. (2004). Emerging Asymmetry And Embryonic Patterning In Early Mouse Development. Developmental Cell, 7(2), 155-164. [More Information]
Robb, L., Tam, P. (2004). Gastrula Organiser And Embryonic Patterning In The Mouse. Seminars in Cell and Developmental Biology, 15(5), 543-554. [More Information]
Weaving, L., Christodoulou, J., Williamson, S., Friend, K., McKenzie, O., Archer, H., Evans, J., Clarke, A., Pelka, G., Tam, P., Lahooti, H., Ellaway, C., Bennetts, B., Watson, C., et al (2004). Mutations Of Cdkl5 Cause A Severe Neurodevelopmental Disorder With Infantile Spasms And Mental Retardation. American Journal of Human Genetics, 75, 1079-1093. [More Information]
Tam, P., Khoo, P., Wong, N., Tsang, T., Behringer, R. (2004). Regionalization Of Cell Fates And Cell Movement In The Endoderm Of The Mouse Gastrula And The Impact Of Loss Of Lhx1(Lim1) Function. Developmental Biology, 274(1), 171-187. [More Information]
Tanaka, S., Nagamatsu, G., Tokitake, Y., Kasa, M., Tam, P., Matsui, Y. (2004). Regulation Of Expression Of Mouse Interferon-Induced Transmembrane Protein Like Gene-3, Ifitm3 (Mil-1, Fragilis), In Germ Cells. Developmental Dynamics, 230(4), 651-659. [More Information]
Ding, H., Schertzer, M., Wu, X., Gertsenstein, M., Selig, S., Kammori, M., Pourvali, R., Poon, S., Vulto, I., et al, Tam, P. (2004). Regulation Of Murine Telomere Length By Rtel: An Essential Gene Encoding A Helicase-Like Protein. Cell, 117(7), 873-886. [More Information]
Loebel, D., Tsoi, B., Wong, N., O'Rourke, M., Tam, P. (2004). Restricted Expression Of Etn-Related Sequences During Post-Implantation Mouse Development. Gene Expression Patterns, 4(4), 467-471. [More Information]

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2003

Hukriede, N., Tsang, T., Habas, R., Khoo, P., Steiner, K., Weeks, D., Tam, P., Dawid, I. (2003). Conserved requirement of Lim1 function for cell movements during gastrulation. Developmental Cell, 4(1), 83-94. [More Information]
Tam, P., Kanai-Azuma, M., Kanai, Y. (2003). Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Current Opinion In Genetics and Development, 13(4), 393-400. [More Information]
Loebel, D., Watson, C., De Young, R., Tam, P. (2003). Lineage choice and differentiation in mouse embryos and embryonic stem cells. Developmental Biology, 264(1), 1-14. [More Information]
Tam, P., Rossant, J. (2003). Mouse embryonic chimeras: tools for studying mammalian development. Development, 130, 6155-6163. [More Information]

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2002

Stone, L., Tan, S., Tam, P., Finger, T. (2002). Analysis of Cell Lineage Relationships in Taste Buds. Journal of Neuroscience, 22(11), 4522-4529. [More Information]
Kanai-Azuma, M., Kanai, Y., Gad, J., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P., et al (2002). Depletion of definitive gut endoderm in Sox17-null mutant mice. Development, 129(10), 2367-2379.
Ristevski, S., Tam, P., Hertzog, P., Kola, I. (2002). Ets2 is expressed during morphogenesis of the somite and limb in the mouse embryo. Mechanisms of Development, 116, 165-168. [More Information]
Tam, P. (2002). First mitotic division: getting it right at the start. Nature Cell Biology, 4(10), E232-E232. [More Information]
Loebel, D., O'Rourke, M., Steiner, K., Banyer, J., Tam, P. (2002). Isolation of Differentially Expressed Genes from Wild-Type and Twist Mutant Mouse Limb Buds. Genesis, 33(3), 103-113. [More Information]
Hart, A., Hartley, L., Sourris, K., Stadler, E., Li, R., Stanley, E., Tam, P., Elefanty, A., Robb, L. (2002). Mixl1 is required for axial mesendoderm morpogenesis and patterning in the murine embryo. Development, 129(15), 3597-3608.
Tam, P., Rossant, J. (2002). Mouse Development: Patterning, Morphogenesis and Organogensis. San Francisco United States: Academic Press.
Tam, P., Gossler, A. (2002). Somitogenesis: Segmentation of the Paraxial Mesodeerm and the delineation of tissue compartments. In Janet Rossant & Patrick L. Tam (Eds.), Mouse Development, (pp. 127-149). San Francisco: Staempfli Publishers Ltd.
Soo, K., O'Rourke, M., Khoo, P., Steiner, K., Wong, N., Behringer, R., Tam, P. (2002). Twist Function is Required for morphogenesis of the Cephalic Neural Tuve and the Differentiation of the Cranial Neura Crest Cells in the Mouse Embryo. Developmental Biology, 247(2), 251-270. [More Information]
O'Rourke, M., Tam, P. (2002). Twist Functions in mouse development. International Journal of Developmental Biology, 46(4), 401-413.
O'Rourke, M., Soo, K., Behringer, R., Hui, C., Tam, P. (2002). Twist plays an essential role in FGF and SHH Signal Transduction during Mouse Limb Development. Developmental Biology, 248(1), 143-156. [More Information]

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2001

Kinder, S., Tam, P., Loebel, D. (2001). Allocation and Early Differentiation of Cardiovascular Progenitors in the Mouse Embryo. Trends In Cardiovascular Medicine, 11, 177-183.
Tam, P., Hadjantonakis, A., Cox,, L., Nagy,, A. (2001). An X-linked GFP transgene reveals unexpected paternal X-Chromosome activity in trophoblastic Giant Cells of the Mouse Placenta. Genesis, 29, 133-140.
Tam, P., Watson,, C. (2001). Cell Lineage Determination in the Mouse. Cell Structure and Function, 26, 123-129.
Kinder, S., Tsang, T., Tam, P., Ang,, S., Behringer, R. (2001). Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3B activity. International Journal of Developmental Biology, 45, 347-355.
Tam, P., Ristevski, S., Kola,, I., Hertzog, P. (2001). Desrt, an AT-rich interaction domain family transcription factor gene, is an early marker for nephrogenic mesoderm and is expressed dynamically during mourse limb development. Mechanisms of Development, 104, 139-142.
Tam, P., So, C., Cheah, K. (2001). Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis. Osteoarthritis and Cartilage, 9.
Orford, J., Manglick, P., Cass, D., Tam, P. (2001). Mechanisms for the development of esophageal atresia. Journal of Pediatric Surgery, 36(7), 985-994. [More Information]
Tam, P., Kinder, S., Tsang, T., Gad, J., Behringer, R. (2001). Morphogenetic tissue movement and the establishment of body plan during development from blastocyst to gastrula in the mouse. BioEssays, 23, 508-517.
Tsang, T., Tam, P., Khoo,, P., Jamieson, R., Zhou,, S., Ang,, S., Behringer, R. (2001). The allocation and differentiation of mouse primordial germ cells. International Journal of Developmental Biology, 45, 549-555.
Kinder, S., Tsang, T., Tam, P., Wakamiya, M., Sasaki, H., Behringer, R., Nagy,, A. (2001). The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development, 128, 3623-3634.

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Selected Grants

2024

Assembling the building blocks in the blueprint of the embryonic head, Tam P, Yang P, Australian Research Council (ARC)/Discovery Projects (DP)

2023

Functional Genomics Enabling Platform, Tam P, Luminesce Alliance/Enabling Platforms Innovation Fund
Purification and cryopreservation of an allogeneic stem cell-derived photoreceptor cell product, Gonzalez Cordero A, Kim H, Tam P, Elwood N, Yang P, Department of Health and Aged Care (Federal)/MRFF - Stem Cell Therapies

2022

DEVELOPMENT OF PHOTORECEPTOR CELL THERAPY TO TREAT BLINDNESS, Elwood N, Gonzalez Cordero A, Wakefield C, Yang P, Hetherington K, Jamieson R, Reddel R, Simunovic M, Tam P, Grigg J, Zreiqat H, Department of Health and Aged Care (Federal - administered by NHMRC)/2021 MRFF Stem Cell Therapies Mission

2019

Paediatric Precision Medicine: Centralized capacity to develop functional genomics for Paediatric Precision Medicine, Tam P, Alexander I, Health Administration Corporation/Research Grant

2018

Capturing tissue-specific progenitors from embryos and stem cells, Tam P, Australian Research Council (ARC)/Discovery Projects (DP)

2017

PYROXD1 - A novel myopathy disease gene identifies a redox pathway essential for life, Cooper S, Tam P, Tam P, Graham M, Graham M, National Health and Medical Research Council (NHMRC)/Project Grants
Sydney Vision Initiative, Alexander I, Grigg J, Jamieson R, Lisowski L, McCluskey P, Schofield D, Simunovic M, Tam P, DVC Research/Sydney Research Excellence Initiative 2020 (SREI)

2016

Rewiring a stem cell: Deciphering the molecular mechanism underpinning lineage propensity, Tam P, Wolvetang E, Cooper-White J, Ovchinnikov D, National Health and Medical Research Council (NHMRC)/Project Grants
Translation of genomics for genetic diagnosis and improved patient management in blinding retinal dystrophy, Jamieson R, Dinger M, Tam P, Grigg J, Bennetts B, Turner A, Schofield D, NSW Ministry of Health, Office for Health and Medical Research/Research Support

2015

Pathways to treatment in blinding genetic retinal eye diseases, Jamieson R, Tam P, Davila S, Grigg J, National Health and Medical Research Council (NHMRC)/Project Grants
Controlling the first step of differentiation of embryonic cells, Tam P, Australian Research Council (ARC)/Discovery Projects (DP)
Re-application of Senior Principal Research Fellowship Development Genomics, Embryology and Stem Cells, Tam P, National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships
Rodent Retinal Analysis Equipment, Alexander I, Tam P, Jamieson R, Liew G, White A, National Health and Medical Research Council (NHMRC)/Equipment Grant
How to build the head: A molecular mechanistic insight, Tam P, Ramialison M, Australian Research Council (ARC)/Discovery Projects (DP)

2014

Controlling the first step of differentiation of embryonic cells , Tam P, DVC Research/Bridging Support Grant

2013

Aberrant mesenchymal-epithelial transition: a pathogenic mechanism in tissue maintenance and differentiation, Tam P, Loebel D, Graham M, Arthur J, National Health and Medical Research Council (NHMRC)/Project Grants
Molecular function of the RNA binding protein, RBM47, in embryonic and mature endoderm cells, Tam P, Arthur J, Australian Research Council (ARC)/Discovery Projects (DP)

2012

Fluidigm BioMark HD - HX, Alexander I, Byrne J, Catchpoole D, Chircop (nee Fabbro) M, Jamieson R, Reddel R, Tam P, Robinson P, Bryan T, Diefenbach R, National Health and Medical Research Council (NHMRC)/Equipment Grant

2011

A molecular paradigm of organ formation during embryonic development: The role of RhoGTPase, Tam P, Loebel D, Australian Research Council (ARC)/Discovery Projects (DP)
Cellular therapy for genetic liver disease exploiting induced pluripotent stem cells and liver progenitor cells, Alexander I, Tam P, Russell D, Yeoh G, National Health and Medical Research Council (NHMRC)/Project Grants

2010

The BD Influx High Speed Cell Sorter, Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X, National Health and Medical Research Council (NHMRC)/Equipment Grant

2009

Westmead Correlative Light and Electron Microscope Suite, North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A, National Health and Medical Research Council (NHMRC)/Equipment Grant
Genetic control of body patterning: Intersection of transciptional and signalling activity in head formation, Tam P, National Health and Medical Research Council (NHMRC)/Project Grants
The BD Influx High Speed Cell Sorter, Kefford R, Cunningham A, Bendall L, Clarke C, Harris D, Alexander S, Tam P, Sorrell T, Iredell J, Bryan T, Rizos H, Wang Y, Hebbard L, National Health and Medical Research Council (NHMRC)/Equipment Grant
Multipotent stem cells derived from postimplantation mouse embryos: Evaluation of germ layer differentiation potential, Tam P, National Health and Medical Research Council (NHMRC)/Project Grants
Head and Face Development: Dissecting the gene functions specific to the precursors, Tam P, Australian Research Council (ARC)/Discovery Projects (DP)

2008

Deltavision (DV) Core Image Restoration, Cunningham A, Turville S, Clarke C, Henderson B, Kefford R, North K, O'Neill G, Murray R, Reddel R, Tam P, Robinson P, Chircop M, National Health and Medical Research Council (NHMRC)/Equipment Grant
Molecular control of embryonic patterning: The function of Rhou gene in mediating response to WNT signalling, Tam P, Robb L, Australian Research Council (ARC)/Discovery Projects (DP)
Identification and Characterisation of Novel Cyclin-Dependent Kinase-like 5 Targets: Implications for Rett Syndrome and Related Neurodevelopmental Disorders, Christodoulou J, Tam P, National Health and Medical Research Council (NHMRC)/Project Grants

2006

Functional Significance of MeCP2 Target Genes in the Pathogenesis of Rett Syndrome, Christodoulou J, Tam P, El-Osta A, National Health and Medical Research Council (NHMRC)/Project Grants

Journal Editor

Editor (2007- current) Development, Company of Biologists

Associate Editor (2002-2010), International Journal of Developmental Biology, UBC Press

Guest Editor, Current Opinion in Cell and Developmental Biology Special Issue on Cellular Reprogramming (2013)

Guest Editor, BioEssays, Special Issue on Stem Cells (2013) Guest Editor, Cold Spring Harbor Perspective in Biology (2012-3)

Managing Editor (2004-2008) Mechanisms of Development, Elsevier and Gene Expression Patterns, Elsevier

Associate Editor, Developmental Cell (2004-2006) Cell Press

Guest Editor (2011), Public Library of Science Genetics (PLoS Genetics) and Ad hoc Academic Editor (2003), Public Library of Science Biology (PLoS Biology) (1992-1995)

Advisory Editor (1996-1997), Anatomy and Embryology, Springer-Verlag

Member of Editorial Board

Developmental Biology, Elsevier (1997-current) Developmental Cell (2006- current) Genesis (Journal of Genetics and Development), Wiley-Liss Inc (2000- current) Differentiation, Springer-Verlag (2000- current) International Journal of Biological Sciences (2006- current) Developmental Dynamics, Wiley-Liss Inc (2003- 2014) International Journal of Developmental Biology, UBC Press (2000-2001) Mechanisms of Development, Elsevier (1994-2003)

Consultation / Advisory / Committee roles

Consultant, Transgenic Core Facility, University of Hong Kong (1996-1997)

Consultant, US National Institute of Health (NIH) National Center for Research Resource project on “Analysis of TMGC mouse developmental defects" of the Chemical Mutagenesis Program of Oak Ridge National Laboratory (Tennessee, USA) (2001)

Consultant, NIH RO1 grant on “Mouse model for human Klinefelter Syndrome”. Principal Investigator: Pauline Yen, Department of Pediatrics, University of California at Los Angeles, Harbor Medical Center (2001)

Discussant, NSW Consultation on the Research Involving Embryos and Prohibition of Human Cloning Bill 2002, NSW Premier Office, May 30 2002

Overseas Scientific Advisor (2000-2005) and Assessor (2003) of the research consortium on “Research into Mesoderm Cells and Organ Formation Clocks as Organ Resources” of the Organized Research Combination System funded by the Monbushu of Japanese Government.

Member of the Scientific Advisory Board of the Australian Research Council Centre of Excellence in Biotechnology and Development (2004-2012)

Ad hoc Advisor, Scientific Advisory Board of the Genome Institute of Singapore, for the research program on Stem Cell Genomics and Developmental Biology (2004, 2005, 2007, 2009).

Member of the Membership Committee of the ARC/NHMRC Research Network on Genes and Environment in Development (2004-6)

Member of Scientific Advisory Board, Institute of Molecular Bioscience, University of Queensland (2006 - 2007)

Chair (2008- 2012), Member (2007) of the Scientific Advisory Board, Chair (2005-2006) and Member (2004) of the Scientific Management Advisory Committee (SMAC), Australian Stem Cell Centre.

Scientific Advisor, Research Centre of Reproduction Development and Growth, Faculty of Medicine, University of Hong Kong (2005-2007)

International Advisor, Stem Cell and Regenerative Medicine Consortium, Li Ka Shing Faculty of Medicine, University of Hong Kong (2009-current)

Member of Scientific Advisory Council, RIKEN Centre for Developmental Biology, Kobe, Japan (2006 – current)

Member of International Scientific Advisory Board, Max Planck Institute of Molecular Genetics, Berlin, Germany (2008-2015) Member of Scientific Advisory Board, Cold Spring Harbor Conference Asia (2008-2011)

Member and Chair of Scientific Advisory Board, Eskitis Institute for Cell and Molecular Therapies, Griffith University (2012-2016)

Member of Sectional Committee 7, Animal Sciences, Australian Academy of Science (2011-2013) Member, Faculty Search Committee, Victor Chang Cardiac Research Institute (2010)

Scientific Advisor, Theme Based Research Scheme, Programs on Intervertebral Disc Regeneration and Leukemia Initiating Cells, Li Ka Shing Faculty of Medicine, University of Hong Kong (2011)

International Member, Section Committee on the International Prize for Biology, Japan Society for Promotion of Science (2011)

Nominator, The Shaw Prize in Life Science and Medicine for 2012-2015 Honorary Advisor, Li Ka Shing Faculty of Medicine, University of Hong Kong (April 2011-March 2013)

Member, Senior Advisory Committee and Visiting Professor, Stem Cell and Regeneration Medicine Consortium, Hong Kong University Li Ka Shing Faculty of Medicine (2012-current)

External Member, Faculty Appointment and Selection Committee, Westmead Millennium Institute (2012)

Member and Chair, Scientific Advisory Committee, Stem Cell Australia (2012 – current)

Official Nominator, Japan Prize (2014-6), Selection Committee of the Japan Prize Foundation (2014) Nominator, Shaw Prize in Life Science and Medicine (2011-2015)

Nominator, Tang Prize for Biopharmaceutical Science, Academia Sinica (2014-2015)

Nominator, Canada Gairdner International Award, Gairdner Foundation (2014, 2016)

External Advisor, Theme Based Research Scheme, “Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform”. Li Ka Shing Faculty of Medicine, University of Hong Kong (2014)

External Advisor, Theme Based Research Scheme, “Cell-Based Heart Regeneration”. Li Ka Shing Faculty of Medicine, University of Hong Kong (2014)

Independent expert advisor, Wellcome Trust Strategic Awards Committee (July 2014)

Member, Scientific Advisory Board, Theme Based Research Scheme, “Genetics and functional genomics of neural crest stem cells and associated disease: Hirschsprung disease” Li Ka Shing Faculty of Medicine, University of Hong Kong (2014-2019)

Member, Person with expertise in Embryology, NHMRC Embryo Research Licensing Committee (2015-2018, 2018-2021)

Member, Scientific Advisory Board, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong (2015-current)

Member, Scientific Advisory Board, Stem Cell Ltd (Stem Core, Australian Institute ofBiotechnology andNanotechnology, Universiity of Queensland) (2019-current)

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Professor Patrick Tam

Selected publications

Publications

By Type

By Year

Selected Grants

2024

2023

2022

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2006