Dr Paul Bonnitcha

Clinical Senior Lecturer
Central Clinical School and Northern Clinical School


Curriculum vitae Curriculum vitae

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Biographical details

Dr Bonnitcha is a Chemical Pathology Registrar at RPA hospital and a Senior Clinical Lecturer at the Northern and Central Clinical Schools in the Medical Faculty. He completed his medical degree at the University of Sydney before undertaking Internship and Residency at RNSH. Prior to this, he completed a PhD at Oxford where he developed imaging agents for hypoxia. His earlier Masters and Honours Projects in the Chemistry Faculty at the University of Sydney were also focused on molecular mechanisms of targeting hypoxia.

Research interests

  • Hypoxia and its role in pathological processes
  • Molecular Imaging
  • Atherosclerosis
  • Oncology
  • Medicinal Chemistry and Drug Design
  • Nuclear Medicine

Teaching and supervision

  • Hypoxia
  • Drug design
  • Biochemistry

Current projects

  • Novel redox sensitive MRI contrast agents for imaging vulnerable plaque, collaborating with:

- Dr Elizabeth New (University of Sydney, Chemistry Department)

- Professor Gemma Figtree (University of Sydney, Medical Faculty, Northern Clinical School)

- Professor Stuart Grieve (Royal North Shore Radiology Department)

- Mr Edward O’Neil (PhD candidate, University of Sydney, Chemistry Department)

  • Positron Emission Tomography for the detection of vulnerable plaques. collaborating with:

- Professor Gemma Figtree (University of Sydney, Medical Faculty, Northern Clinical School)

- Dr Edward Hsiao (Royal North Shore Nuclear Medicine Department)

- Professor Stuart Grieve (Royal North Shore Radiology Department)

- Professor Martin Krause Bailey (Royal North Shore Neurology Department)

- Dr Charles Fisher (Royal North Shore Vascular Surgery Department)


Associations

Royal College of Pathologists of Australasia - Trainee

Australasian Association of Clinical Biochemists - Member

Royal Australian Chemistry Institute (RACI) - Chartered Chemist

World Molecular Imaging Society (WMIS) - Member

Advance Drug Development through Molecular Imaging (ADDMI) - Member

Awards and honours

  • Sydney Medical School Foundation Fellowship 2016

  • Junior Medical Officer Teaching Award, Royal North Shore Hospital 2015
  • Professor CRB Blackburn Prize, Sydney Medical Program 2014
  • Junior Medical Officer Teaching Award, Royal North Shore Hospital 2014
  • Sydney Medical Program Elective Scholarship 2013
  • Centennial Trust Scholarship, Old Newingtonian Union 2012
  • USMLE Scholarship (declined), Sydney Medical Program 2011
  • Commonwealth Scholarship, Oxford University, United Kingdom 2005 - 2009
  • Agnes Campbell Prize, University of Sydney, School of Chemistry 2005
  • University of Sydney Postgraduate Award 2005
  • University Medal (Chemistry), University of Sydney 2004
  • Honours Scholarship (Merit), University of Sydney 2004
  • Royal Australian Chemistry Institute Masson Memorial Scholarship Prize 2004
  • Science Faculty Dean’s Honour List, University of Sydney 2001 - 2003
  • Walter Burfitt Scholarship No 1, University of Sydney, Chemistry Faculty 2003
  • University Senate Scholarship, Sydney University Sport Union 2002
  • International Exchange Scholarship, University of Sydney 2002
  • Continuing Undergraduate Scholarship, University of Sydney 2002
  • Yachting NSW Nomination for Senior Sailor of the Year 2002
  • Golden Key International Honour Society Scholastic Scholarship 2002
  • Levee No. 1 Scholarship for Physics, University of Sydney, Physics Faculty 2001
  • Science Entry Scholarship, University of Sydney, Science Faculty 2001
  • Science Alumni Scholarship, University of Sydney, Science Faculty 2001
  • E Trenchard Miller Scholarship, University of Sydney 2001

Selected grants

2016

  • Positron Emission Tomography for the Detection of Vulnerable Plaques; Bonnitcha P; Sydney Medical School Foundation/Foundation Grant.

2014

  • Novel hypoxia selective MRI contrast agents; Bonnitcha P, New E, Grieve S; Heart Research Australia./Research Support.

Selected publications

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Journals

  • Bonnitcha, P., Grieve, S., Figtree, G. (2018). Clinical imaging of hypoxia: Current status and future directions. Free Radical Biology and Medicine, 126, 296-312. [More Information]
  • Sullivan, D., Bonnitcha, P., Spinks, C., Keech, A. (2018). PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Status and Protection Against Ischemic Stroke: PheWAS, TreWAS, and More. Circulation. Genomic and Precision Medicine, 11(7), 1-3. [More Information]
  • O'Neill, E., Kolanowski, J., Bonnitcha, P., New, E. (2017). A cobalt(II) complex with unique paraSHIFT responses to anions. Chemical Communications, 53(25), 3571-3574. [More Information]
  • O'Neill, E., Kaur, A., Bishop, D., Shishmarev, D., Kuchel, P., Grieve, S., Figtree, G., Renfrew, A., Bonnitcha, P., New, E. (2017). Hypoxia-responsive cobalt complexes in tumor spheroids: Laser ablation inductively coupled plasma mass spectrometry and magnetic resonance imaging studies. Inorganic Chemistry, 56(16), 9860-9868. [More Information]
  • O'Neill, E., Kolanowski, J., Yin, G., Broadhouse, K., Grieve, S., Renfrew, A., Bonnitcha, P., New, E. (2016). Reversible magnetogenic cobalt complexes. RSC Advances, 6(36), 30021-30027. [More Information]
  • Betts, H., Pascu, S., Buchard, A., Bonnitcha, P., Dilworth, J. (2014). One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(II) complexes. RSC Advances, 4(25), 12964-12970. [More Information]
  • Zhang, J., Bonnitcha, P., Wexselblatt, E., Klein, A., Najajreh, Y., Gibson, D., Hambley, T. (2013). Facile preparation of mono-, di- and mixed-carboxylato platinum(IV) complexes for versatile anticancer prodrug design. Chemistry - A European Journal, 19(5), 1672-1676. [More Information]
  • Bonnitcha, P., Kim, B., Hocking, R., Clegg, J., Turner, P., Neville, S., Hambley, T. (2012). Cobalt complexes with tripodal ligands: Implications for the design of drug chaperones. Dalton Transactions, 41(37), 11293-11304. [More Information]
  • Bonnitcha, P., Bayly, S., Theobald, M., Betts, H., Lewis, J., Dilworth, J. (2010). Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia. Journal of Inorganic Biochemistry, 104(2), 126-135. [More Information]
  • Carroll, L., Bejot, R., Hueting, R., King, R., Bonnitcha, P., Bayly, S., Christlieb, M., Dilworth, J., Gee, A., Declerck, J., et al (2010). Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes. Chemical Communications, 46(23), 4052-4054. [More Information]
  • Holland, J., Jones, M., Bonnitcha, P., Lewis, J., Dilworth, J. (2009). Functionalised copper-64 complexes as precursors of potential PET imaging agents for neurodegenerative disorders. New Journal of Chemistry, 33(9), 1845-1852. [More Information]
  • Yamamoto, N., Danos, S., Bonnitcha, P., Failes, T., New, E., Hambley, T. (2008). Cellular uptake and distribution of cobalt complexes of fluorescent ligands. Journal of Biological Inorganic Chemistry, 13(6), 861-871. [More Information]
  • Bonnitcha, P., Hall, M., Underwood, C., Foran, G., Zhang, M., Beale, P., Hambley, T. (2006). XANES investigation of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes. Journal of Inorganic Biochemistry, 100(5-6), 963-971. [More Information]

2018

  • Bonnitcha, P., Grieve, S., Figtree, G. (2018). Clinical imaging of hypoxia: Current status and future directions. Free Radical Biology and Medicine, 126, 296-312. [More Information]
  • Sullivan, D., Bonnitcha, P., Spinks, C., Keech, A. (2018). PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Status and Protection Against Ischemic Stroke: PheWAS, TreWAS, and More. Circulation. Genomic and Precision Medicine, 11(7), 1-3. [More Information]

2017

  • O'Neill, E., Kolanowski, J., Bonnitcha, P., New, E. (2017). A cobalt(II) complex with unique paraSHIFT responses to anions. Chemical Communications, 53(25), 3571-3574. [More Information]
  • O'Neill, E., Kaur, A., Bishop, D., Shishmarev, D., Kuchel, P., Grieve, S., Figtree, G., Renfrew, A., Bonnitcha, P., New, E. (2017). Hypoxia-responsive cobalt complexes in tumor spheroids: Laser ablation inductively coupled plasma mass spectrometry and magnetic resonance imaging studies. Inorganic Chemistry, 56(16), 9860-9868. [More Information]

2016

  • O'Neill, E., Kolanowski, J., Yin, G., Broadhouse, K., Grieve, S., Renfrew, A., Bonnitcha, P., New, E. (2016). Reversible magnetogenic cobalt complexes. RSC Advances, 6(36), 30021-30027. [More Information]

2014

  • Betts, H., Pascu, S., Buchard, A., Bonnitcha, P., Dilworth, J. (2014). One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(II) complexes. RSC Advances, 4(25), 12964-12970. [More Information]

2013

  • Zhang, J., Bonnitcha, P., Wexselblatt, E., Klein, A., Najajreh, Y., Gibson, D., Hambley, T. (2013). Facile preparation of mono-, di- and mixed-carboxylato platinum(IV) complexes for versatile anticancer prodrug design. Chemistry - A European Journal, 19(5), 1672-1676. [More Information]

2012

  • Bonnitcha, P., Kim, B., Hocking, R., Clegg, J., Turner, P., Neville, S., Hambley, T. (2012). Cobalt complexes with tripodal ligands: Implications for the design of drug chaperones. Dalton Transactions, 41(37), 11293-11304. [More Information]

2010

  • Bonnitcha, P., Bayly, S., Theobald, M., Betts, H., Lewis, J., Dilworth, J. (2010). Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia. Journal of Inorganic Biochemistry, 104(2), 126-135. [More Information]
  • Carroll, L., Bejot, R., Hueting, R., King, R., Bonnitcha, P., Bayly, S., Christlieb, M., Dilworth, J., Gee, A., Declerck, J., et al (2010). Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes. Chemical Communications, 46(23), 4052-4054. [More Information]

2009

  • Holland, J., Jones, M., Bonnitcha, P., Lewis, J., Dilworth, J. (2009). Functionalised copper-64 complexes as precursors of potential PET imaging agents for neurodegenerative disorders. New Journal of Chemistry, 33(9), 1845-1852. [More Information]

2008

  • Yamamoto, N., Danos, S., Bonnitcha, P., Failes, T., New, E., Hambley, T. (2008). Cellular uptake and distribution of cobalt complexes of fluorescent ligands. Journal of Biological Inorganic Chemistry, 13(6), 861-871. [More Information]

2006

  • Bonnitcha, P., Hall, M., Underwood, C., Foran, G., Zhang, M., Beale, P., Hambley, T. (2006). XANES investigation of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes. Journal of Inorganic Biochemistry, 100(5-6), 963-971. [More Information]

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