Professor John Seale

Professor
Pharmacology, School of Medical Sciences

Telephone +61 2 9351 3819
Fax +61 2 9351 4717

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Selected grants

2012

  • Low dose corticosteroids and theophylline in the treatment of COPD; Berend N, Jenkins C, Barnes P, Celli B, Seale J; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Luminex 200 multi-functional analysis system for shared use in the Blackburn precinct; Seale J; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
  • A randomized clinical trial comparing effectiveness of 4RIF and 9INH for treatment of latent TB infection; Marks G, Menzie R, Seale J; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Phosphodiesterase Inhibitors Enchance Bone Mass (PDE4 inhibitation) - Altana Pharma Pty Ltd; Rasmussen M, Seale J, Mason R; Altana Pharma Pty Ltd, Germany/BLO Project.
  • Role of protein kinase C, especially PKC-theta in the development of insulin resistance; Donnelly R, Seale J; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Novel non-steroidal analogues; Seale J; Dow Chemical (Australia) Pty Ltd/Research Support.
  • Beclomethasone trials; Seale J; 3M Pharmaceuticals Pty Ltd/Research Support.

Selected publications

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Book Chapters

  • Keech, A., Seale, J., Gebski, V. (2007). Generalising the results of trials to clinical practice. In Anthony Keech, Val Gebski, Rhana Pike (Eds.), Interpreting and reporting clinical trials: a guide to the CONSORT statement and the principles of randomised controlled trials, (pp. 149-153). Sydney: AMPCo.

Journals

  • Seale, J. (2014). Off-label prescribing. Medical Journal of Australia, 22(2), 65-65. [More Information]
  • Seale, J. (2013). A woman with a cough not responding to routine antibiotics. Medicine Today, 14(6), 68-69.
  • Tan, Y., Lao, W., Xiao, L., Wang, Z., Xiao, W., Kamal, M., Seale, J., Qu, X. (2013). Managing the combination of nonalcoholic Fatty liver disease and metabolic syndrome with chinese herbal extracts in high-fat-diet fed rats. Evidence-Based Complementary and Alternative Medicine, 2013, 1-10. [More Information]
  • Tan, Y., Kamal, M., Wang, Z., Xiao, W., Seale, J., Qu, X. (2011). Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome. Clinical Science, 120(7), 297-305. [More Information]
  • Ayer, J., Harmer, J., David, C., Steinbeck, K., Seale, J., Celermajer, D. (2011). Severe obesity is associated with impaired arterial smooth muscle function in young adults. Obesity, 19(1), 54-60.
  • Tan, Y., Sun, L., Kamal, M., Wang, X., Seale, J., Qu, X. (2011). Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolic syndrome and non-alcoholic fatty liver disease in mice. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1811 (12), 1045-1053. [More Information]
  • Ajjawi, R., Thistlethwaite, J., Williams, K., Ryan, G., Seale, J., Carroll, P. (2010). Breaking down professional barriers: Medicine and pharmacy students learning together. Focus on Health Professional Education: a multi-disciplinary journal, 12(1), 1-10.
  • Seale, J. (2010). European Respiratory Society (ERS) - 20th Annual Congress. IDrugs : the investigational drugs journal, 13(11), 762-764. [More Information]
  • Ayer, J., Harmer, J., David, C., Steinbeck, K., Seale, J., Celermajer, D. (2010). Severe Obesity Is Associated With Impaired Arterial Smooth Muscle Function in Young Adults. Obesity, 19(1), 54-60. [More Information]
  • Anderson, S., Brannan, J., Perry, C., Caillaud, C., Seale, J. (2010). Sodium Cromoglycate Alone and in Combination With Montelukast on the Airway Response to Mannitol in Asthmatic Subjects. Journal of Asthma, 47(4), 429-433. [More Information]
  • Seale, J., Jenkins, C., Wood-Baker, R., Neville, A. (2009). Benefits of fixed-dose combination therapy with inhaled corticosteroids and long-acting bronchodilators as initial maintenance therapy in the management of asthma. Respirology, 14(2), 224-229. [More Information]
  • Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
  • Seale, J., Kamal, M., Tan, Y., Qu, X. (2009). Targeting BuChE-inflammatory Pathway by SK0506 to Manage Type 2 Diabetes and Alzheimer Disease. Neurochemical Research, 34(12), 2163-2169. [More Information]
  • Kim, J., Xiao, H., Tan, Y., Wang, Z., Seale, J., Qu, X. (2009). The Effects and Mechanism of Saponins of Panax notoginseng on Glucose Metabolism in 3T3-L1 Cells. American Journal of Chinese Medicine, 37(6), 1179-1189.
  • Tan, W., Seale, J., Ip, M., Shim, Y., Chiang, C., Ng, T., Abisheganadan, J., Charoenratanakul, S., DeGuia, T., Mahayiddin, A., et al (2009). Trends in COPD mortality and hospitalizations in countries and regions of Asia-Pacific. Respirology, 14(1), 90-97. [More Information]
  • Dang, L., Seale, J., Qu, X. (2007). Effects of hypocrellin A on expression of vascular endothelial growth factor and endothelin-1 in human umbilical endothelial cells. American Journal of Chinese Medicine, 35(4), 713-723. [More Information]
  • Seale, J. (2007). Omalizumab symposium. Respirology, 12, S17; discussion S45-7. [More Information]
  • Seale, J. (2006). Asian Pacific Society of Respirology--tenth congress and first joint congress with the American College of Chest Physicians. 11-14 November 2005, Guangzhou, China. IDrugs : the investigational drugs journal, 9(1), 23-4. [More Information]
  • Yang, Q., Phillips, C., Melehan, K., Rogers, N., Seale, J., Grunstein, R. (2006). Effects of short-term CPAP withdrawal on neurobehavioral performance in patients with obstructive sleep apnea. Sleep, 29(4), 545-552. [More Information]
  • Brannan, J., Gulliksson, M., Anderson, S., Chew, N., Seale, J., Kumlin, M. (2006). Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing. European Respiratory Journal, 27(5), 944-950. [More Information]
  • Tobin, P., Clarke, S., Seale, J., Lee, S., Solomon, M., Aulds, S., Crawford, M., Gallagher, J., Eyers, T., Rivory, L. (2006). The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and beta-glucuronidase in human colorectal tumours. British Journal of Clinical Pharmacology, 62(1), 122-129. [More Information]
  • Day, R., Birkett, D., Miners, J., Shenfield, G., Henry, D., Seale, J. (2005). Access to medicines and high-quality therapeutics: global responsibilities for clinical pharmacology. A major theme of the 2004 World Congress of Clinical Pharmacology and Therapeutics was worldwide equity of access to medicines. Medical Journal of Australia, 182(7), 322-3. [More Information]
  • Hilmer, S., Seale, J. (2005). Alternatives to injectable opioids for acute analgesia. Medicine Today, 6, 39-47.
  • Dang, L., Seale, J., Qu, X. (2005). High glucose-induced human umbilical vein endothelial cell hyperpermeability is dependent on protein kinase C activation and independent of the Ca2+-nitric oxide signalling pathway. Clinical and Experimental Pharmacology and Physiology, 32(9), 771-776. [More Information]
  • Sivagurunathan, S., Muir, M., Speranza, T., Seale, J., Mason, R. (2005). Influence of glucocorticoids on human osteoclast generation and activity. Journal of Bone and Mineral Research, 20(3), 390-398. [More Information]
  • Seale, J. (2005). Is the pharmacology of corticosteroids in the lung modified by age? Medical Journal of Australia, 183(1), S47-8. [More Information]
  • Tobin, P., Hong, Y., Seale, J., Rivory, L., McLachlan, A. (2005). Loperamide inhibits the biliary excretion of irinotecan (CPT-11) in the rat isolated perfused liver. Journal of Pharmacy and Pharmacology, 57, 39-45. [More Information]
  • Daviskas, E., Anderson, S., Shaw, J., Eberl, S., Seale, J., Yang, I., Young, I. (2005). Mucociliary clearance in patients with chronic asthma: effects of beta agonists. Respirology, 10(4), 426-435. [More Information]
  • Seale, J., Gebski, V., Keech, A. (2004). Generalising the results of trials to clinical practice. Medical Journal of Australia, 181(10), 558-560.
  • Dang, L., Seale, J., Qu, X. (2004). Reduction Of High Glucose And Phorbol-Myristate-Acetate-Induced Endothelial Cell Permeability By Protein Kinase C Inhibitors Ly379196 And Hypocrellin A. Biochemical Pharmacology, 67(5), 855-864. [More Information]
  • Tan, W., Seale, J., Charaoenratanakul, S., De Guia, T., Ip, M., Mahayiddin, A., Mangunnegoro, H., Luh, K., Shim, Y., Zhong, N., et al (2003). COPD prevalence in 12 Asia-Pacific countries and regions: Projections based on the COPD prevalance estimation model. Respirology, 8(2), 192-198.
  • Qu, X., Dang, L., Seale, J. (2003). Inhibitory effect of hypocrellin A on protein kinase C in liver and skeletal muscle of obese zucker rats. American Journal of Chinese Medicine, 11, 871-878.
  • Seale, J. (2003). Science and physicianly practice: are they compatible? Clinical and Experimental Pharmacology and Physiology, 30(11), 833-835.
  • Daviskas, E., Anderson, S., Eberl, S., Chan, K., Young, I., Seale, J. (2002). Effects of terbutaline in combination with mannitol on mucociliary clearance. European Respiratory Journal, 20, 1423-1429.
  • Seale, J., Donnelly, R. (2001). Clinical Pharmacokinetics of Inhaled Budesonide. Clinical Pharmacokinetics, 40, 427-440.
  • Brannan, J., Chan, K., Seale, J., Anderson, S., Gomes,, K., King,, G. (2001). Fexofenadine decreases sensitivity to and Montelukast improves recovery from inhaled Mannitol. American Journal of Respiratory and Critical Care Medicine, 163(6), 1420-1425.
  • Seale, J., Celermajer, D., Raitakari, O. (2001). Impaired vascular responses to nitroglycerin in subjects with coronary atherosclerosis. The American Journal of Cardiology, 87, 217-219.
  • Li, Y., Tattam, B., Brown, K., Seale, J. (2001). Quantification of epimeric budesonide and fluticasone propionate in human plasma by liquid chromatography - atmospheric pressure chemical ionization tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 761, 177-185.
  • Rivory, L., Charles (nee Slaviero), K., Seale, J., Hoskins, J., Boyer, M., Beale, P., Millward, M., Bishop, J., Clarke, S. (2000). Optimizing the erythromycin breath test for use in cancer patients. Clinical Cancer Research, 6, 3480-3485.

Conferences

  • Sivagurunathan, S., Muir, M., Seale, J., Mason, R. (2003). Glucocorticoid influence on osteoclast generation and activity. International Conference on Metabolic Bone Disease in conjunction with the 13th Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society.
  • Sivagurunathan, S., Muir, M., Seale, J., Mason, R. (2002). Direct effects of dexamethasone on osteoclasts and precursors. 8th Annual Meeting of the Australian and New Zealand Orthopaedic Research Society.
  • Seeto, C., Roth, M., Hughes, M., Seale, J., Armour, C. (2001). Combination of Budesonide and Formoterol inhibits T-lymphocyte proliferation and IL5 production. BioInnovation: the future of medical research, : Ads & Adea.
  • Sivagurunathan, S., Muir, M., Seale, J., Mason, R. (2001). Dexamethasone modulates osteoclast responsiveness to rankl. 7th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society.

2014

  • Seale, J. (2014). Off-label prescribing. Medical Journal of Australia, 22(2), 65-65. [More Information]

2013

  • Seale, J. (2013). A woman with a cough not responding to routine antibiotics. Medicine Today, 14(6), 68-69.
  • Tan, Y., Lao, W., Xiao, L., Wang, Z., Xiao, W., Kamal, M., Seale, J., Qu, X. (2013). Managing the combination of nonalcoholic Fatty liver disease and metabolic syndrome with chinese herbal extracts in high-fat-diet fed rats. Evidence-Based Complementary and Alternative Medicine, 2013, 1-10. [More Information]

2011

  • Tan, Y., Kamal, M., Wang, Z., Xiao, W., Seale, J., Qu, X. (2011). Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome. Clinical Science, 120(7), 297-305. [More Information]
  • Ayer, J., Harmer, J., David, C., Steinbeck, K., Seale, J., Celermajer, D. (2011). Severe obesity is associated with impaired arterial smooth muscle function in young adults. Obesity, 19(1), 54-60.
  • Tan, Y., Sun, L., Kamal, M., Wang, X., Seale, J., Qu, X. (2011). Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolic syndrome and non-alcoholic fatty liver disease in mice. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1811 (12), 1045-1053. [More Information]

2010

  • Ajjawi, R., Thistlethwaite, J., Williams, K., Ryan, G., Seale, J., Carroll, P. (2010). Breaking down professional barriers: Medicine and pharmacy students learning together. Focus on Health Professional Education: a multi-disciplinary journal, 12(1), 1-10.
  • Seale, J. (2010). European Respiratory Society (ERS) - 20th Annual Congress. IDrugs : the investigational drugs journal, 13(11), 762-764. [More Information]
  • Ayer, J., Harmer, J., David, C., Steinbeck, K., Seale, J., Celermajer, D. (2010). Severe Obesity Is Associated With Impaired Arterial Smooth Muscle Function in Young Adults. Obesity, 19(1), 54-60. [More Information]
  • Anderson, S., Brannan, J., Perry, C., Caillaud, C., Seale, J. (2010). Sodium Cromoglycate Alone and in Combination With Montelukast on the Airway Response to Mannitol in Asthmatic Subjects. Journal of Asthma, 47(4), 429-433. [More Information]

2009

  • Seale, J., Jenkins, C., Wood-Baker, R., Neville, A. (2009). Benefits of fixed-dose combination therapy with inhaled corticosteroids and long-acting bronchodilators as initial maintenance therapy in the management of asthma. Respirology, 14(2), 224-229. [More Information]
  • Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
  • Seale, J., Kamal, M., Tan, Y., Qu, X. (2009). Targeting BuChE-inflammatory Pathway by SK0506 to Manage Type 2 Diabetes and Alzheimer Disease. Neurochemical Research, 34(12), 2163-2169. [More Information]
  • Kim, J., Xiao, H., Tan, Y., Wang, Z., Seale, J., Qu, X. (2009). The Effects and Mechanism of Saponins of Panax notoginseng on Glucose Metabolism in 3T3-L1 Cells. American Journal of Chinese Medicine, 37(6), 1179-1189.
  • Tan, W., Seale, J., Ip, M., Shim, Y., Chiang, C., Ng, T., Abisheganadan, J., Charoenratanakul, S., DeGuia, T., Mahayiddin, A., et al (2009). Trends in COPD mortality and hospitalizations in countries and regions of Asia-Pacific. Respirology, 14(1), 90-97. [More Information]

2007

  • Dang, L., Seale, J., Qu, X. (2007). Effects of hypocrellin A on expression of vascular endothelial growth factor and endothelin-1 in human umbilical endothelial cells. American Journal of Chinese Medicine, 35(4), 713-723. [More Information]
  • Keech, A., Seale, J., Gebski, V. (2007). Generalising the results of trials to clinical practice. In Anthony Keech, Val Gebski, Rhana Pike (Eds.), Interpreting and reporting clinical trials: a guide to the CONSORT statement and the principles of randomised controlled trials, (pp. 149-153). Sydney: AMPCo.
  • Seale, J. (2007). Omalizumab symposium. Respirology, 12, S17; discussion S45-7. [More Information]

2006

  • Seale, J. (2006). Asian Pacific Society of Respirology--tenth congress and first joint congress with the American College of Chest Physicians. 11-14 November 2005, Guangzhou, China. IDrugs : the investigational drugs journal, 9(1), 23-4. [More Information]
  • Yang, Q., Phillips, C., Melehan, K., Rogers, N., Seale, J., Grunstein, R. (2006). Effects of short-term CPAP withdrawal on neurobehavioral performance in patients with obstructive sleep apnea. Sleep, 29(4), 545-552. [More Information]
  • Brannan, J., Gulliksson, M., Anderson, S., Chew, N., Seale, J., Kumlin, M. (2006). Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing. European Respiratory Journal, 27(5), 944-950. [More Information]
  • Tobin, P., Clarke, S., Seale, J., Lee, S., Solomon, M., Aulds, S., Crawford, M., Gallagher, J., Eyers, T., Rivory, L. (2006). The in vitro metabolism of irinotecan (CPT-11) by carboxylesterase and beta-glucuronidase in human colorectal tumours. British Journal of Clinical Pharmacology, 62(1), 122-129. [More Information]

2005

  • Day, R., Birkett, D., Miners, J., Shenfield, G., Henry, D., Seale, J. (2005). Access to medicines and high-quality therapeutics: global responsibilities for clinical pharmacology. A major theme of the 2004 World Congress of Clinical Pharmacology and Therapeutics was worldwide equity of access to medicines. Medical Journal of Australia, 182(7), 322-3. [More Information]
  • Hilmer, S., Seale, J. (2005). Alternatives to injectable opioids for acute analgesia. Medicine Today, 6, 39-47.
  • Dang, L., Seale, J., Qu, X. (2005). High glucose-induced human umbilical vein endothelial cell hyperpermeability is dependent on protein kinase C activation and independent of the Ca2+-nitric oxide signalling pathway. Clinical and Experimental Pharmacology and Physiology, 32(9), 771-776. [More Information]
  • Sivagurunathan, S., Muir, M., Speranza, T., Seale, J., Mason, R. (2005). Influence of glucocorticoids on human osteoclast generation and activity. Journal of Bone and Mineral Research, 20(3), 390-398. [More Information]
  • Seale, J. (2005). Is the pharmacology of corticosteroids in the lung modified by age? Medical Journal of Australia, 183(1), S47-8. [More Information]
  • Tobin, P., Hong, Y., Seale, J., Rivory, L., McLachlan, A. (2005). Loperamide inhibits the biliary excretion of irinotecan (CPT-11) in the rat isolated perfused liver. Journal of Pharmacy and Pharmacology, 57, 39-45. [More Information]
  • Daviskas, E., Anderson, S., Shaw, J., Eberl, S., Seale, J., Yang, I., Young, I. (2005). Mucociliary clearance in patients with chronic asthma: effects of beta agonists. Respirology, 10(4), 426-435. [More Information]

2004

  • Seale, J., Gebski, V., Keech, A. (2004). Generalising the results of trials to clinical practice. Medical Journal of Australia, 181(10), 558-560.
  • Dang, L., Seale, J., Qu, X. (2004). Reduction Of High Glucose And Phorbol-Myristate-Acetate-Induced Endothelial Cell Permeability By Protein Kinase C Inhibitors Ly379196 And Hypocrellin A. Biochemical Pharmacology, 67(5), 855-864. [More Information]

2003

  • Tan, W., Seale, J., Charaoenratanakul, S., De Guia, T., Ip, M., Mahayiddin, A., Mangunnegoro, H., Luh, K., Shim, Y., Zhong, N., et al (2003). COPD prevalence in 12 Asia-Pacific countries and regions: Projections based on the COPD prevalance estimation model. Respirology, 8(2), 192-198.
  • Sivagurunathan, S., Muir, M., Seale, J., Mason, R. (2003). Glucocorticoid influence on osteoclast generation and activity. International Conference on Metabolic Bone Disease in conjunction with the 13th Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society.
  • Qu, X., Dang, L., Seale, J. (2003). Inhibitory effect of hypocrellin A on protein kinase C in liver and skeletal muscle of obese zucker rats. American Journal of Chinese Medicine, 11, 871-878.
  • Seale, J. (2003). Science and physicianly practice: are they compatible? Clinical and Experimental Pharmacology and Physiology, 30(11), 833-835.

2002

  • Sivagurunathan, S., Muir, M., Seale, J., Mason, R. (2002). Direct effects of dexamethasone on osteoclasts and precursors. 8th Annual Meeting of the Australian and New Zealand Orthopaedic Research Society.
  • Daviskas, E., Anderson, S., Eberl, S., Chan, K., Young, I., Seale, J. (2002). Effects of terbutaline in combination with mannitol on mucociliary clearance. European Respiratory Journal, 20, 1423-1429.

2001

  • Seale, J., Donnelly, R. (2001). Clinical Pharmacokinetics of Inhaled Budesonide. Clinical Pharmacokinetics, 40, 427-440.
  • Seeto, C., Roth, M., Hughes, M., Seale, J., Armour, C. (2001). Combination of Budesonide and Formoterol inhibits T-lymphocyte proliferation and IL5 production. BioInnovation: the future of medical research, : Ads & Adea.
  • Sivagurunathan, S., Muir, M., Seale, J., Mason, R. (2001). Dexamethasone modulates osteoclast responsiveness to rankl. 7th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society.
  • Brannan, J., Chan, K., Seale, J., Anderson, S., Gomes,, K., King,, G. (2001). Fexofenadine decreases sensitivity to and Montelukast improves recovery from inhaled Mannitol. American Journal of Respiratory and Critical Care Medicine, 163(6), 1420-1425.
  • Seale, J., Celermajer, D., Raitakari, O. (2001). Impaired vascular responses to nitroglycerin in subjects with coronary atherosclerosis. The American Journal of Cardiology, 87, 217-219.
  • Li, Y., Tattam, B., Brown, K., Seale, J. (2001). Quantification of epimeric budesonide and fluticasone propionate in human plasma by liquid chromatography - atmospheric pressure chemical ionization tandem mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 761, 177-185.

2000

  • Rivory, L., Charles (nee Slaviero), K., Seale, J., Hoskins, J., Boyer, M., Beale, P., Millward, M., Bishop, J., Clarke, S. (2000). Optimizing the erythromycin breath test for use in cancer patients. Clinical Cancer Research, 6, 3480-3485.

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