Associate Professor Paul Witting

Associate Professor Discipline of Pathology
Pathology, School of Medical Sciences

Telephone 02 9114 0524
Fax 02 9351 3429

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Biographical details

Dr Paul Witting is an Associate Professor in the Discipline of Pathology at The University of Sydney and a career biomedical researcher. He has held ARC (2003-2007) and National Heart Foundation Fellowships (1999-2001) that financed post-doctoral terms at the ANZAC Research Institute and University of British Columbia (Canada), respectively. He has a proven track record in the field of bio-medical chemistry publishing 93 peer-reviewed papers (mean impact factor (IF) ~4.9 with >90% appearing in international journals); 6-book chapters; 10-invited review articles and one International Patent. Publications by Witting and his co-workers have been acknowledged with 2144 citations (mean citation/publication ~23 yielding an H-index ~31). He has been awarded ~A$7.2 Million in competitive funding from agencies including the ARC, NHF, Wellcome Trust, NHMRC Equipment Grants, The Ramaciotti, Bushell and CASS Foundations, Eli Lilly Diabetes Foundation, Servier International, Diabetes Australia Research Trust and the University of Sydney Strategic Development Grants Scheme.

In July of 2008 Witting moved from the ANZAC Research Institute to take up a full time Senior Lectureship and establish the Redox Biology Group in the Discipline of Pathology, The new facility combined with significant funding from the ARC and National Heart Foundation over the next 3 years provides an excellent environment for young researchers to be trained in biomedical techniques and explore the relationships between oxidative stress and disease.

Research interests

Dr Witting's research interest is in exploring the relationship between oxidative stress and the evolution of tissue damage in the acute setting of stroke and myocardial infarct. He is also collaborating with clinicians in the Concord Hospital Burns Unit as he examines the relationship between severe burn, muscle myolysis and acute renal failure.

Teaching and supervision

Teaching Portfolio includes USydMP (Block 8 and 9); Bachelor of Medical Science (2nd year), Cell Pathology (3rd Year; CPAT3202/3201) and in the Surgical Pathology component of a Masters in Surgery.

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

International links

Canada

(The University of British Columbia) Collaborative work with Professor A. Grant Mauk

New Zealand

(Otago University (Dunedin)) Seleno-organic compounds as antioxidants

Selected grants

2015

  • Bruker Fourier Transform Infrared Circular Dichroism Accessory; Lay P, Hawkins C, Grau G, Witting P, Chan K; DVC Research/Equipment Grant.

2014

  • Agents targeting iron in the brain in Parkinsons disease; Codd R, Double K, Liddell J, Witting P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Redox Control of the Immune Regulatory Protein, Indoleamine 2,3-dioxygenase; Thomas S, Witting P, King N; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • SF-61SX2/s stopped-flow fluorimeter and Service and upgrade of SX-17MV stopped-flow spectrometer; Clarke R, Davies M, Lay P, Witting P, Rasmussen H, Matthews J, Pattison D, Vandenberg J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The mode of action of the haem protein neuroglobin in protecting nerve cells; Witting P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • Approaches to inhibit SAA-induced endothelial dysfunction and atherosclerosis; Witting P, Freedman B, Geczy C, Skilton M, Sullivan D; Heart Foundation of Australia/Grants-in-Aid.
  • The role of Neuroglobin in Alzheimers Disease; Witting P, Sutherland G; Judith Jane Mason and Harold Stannett Williams Memorial Foundation/Medical and Scientific Research Grants.

2010

  • Oxidative Stress Bioanalytical Facility; Stocker R, Hunt N, Mason R, Witting P, Roufogalis B, Lay P, Tiganis T, Davies M, Dawes I, Drummond G, Geczy C, Kachigian L, Hogg P, Lackmann M, Thomas S, Croft K, King N, Tilley L, James D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • The Role of Snoring Vibrations in the Pathogenesis of Early Carotid Artery Atherosclerosis; Wheatley J, Amis T, Witting P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • StreamLineTM Plus- Rapid Chemical Mapping; Lay P, Grau G, Richardson D, Hambley T, Witting P, Carter E; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The fate of dieatary selenium in vivo; a direct approach to linking chemical form with biological activity; Harris H, Witting P, Giles G; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • Developing neuro-protective antioxidants that synergise with thrombolytic treatments for actute cerebral ischemia; Witting P, Corbett A; Heart Foundation of Australia/Grants-in-Aid.
  • Cellular response to pro-oxidative myoglobin; Witting P; Australian Research Council (ARC)/Discovery Projects (DP).

2007

  • The Stinger Compact anaesthetic machine, Inspira advanced Safety Ventilator, Electrosurgical unit, Stand-alone Digital Pulse Oximeter; Witting P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Cellular response to pro-oxidative myoglobin - relinquished; Witting P; DVC Research/Bridging Support Fellowship.
  • Twister microplate handle: A robotic system for the Bruker HTS-XT infrared module.; Lay P, Hunt N, Grau G, Sorrell T, Witting P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Role for Myoglobin in myocardial ischemia reperfusion injury.; Witting P; National Heart Foundation/Scholarship.
  • Leica CM3050 S cryostat; Seibel M, Blair J, Dunstan C, Handelsman D, Nicholson G, Kennerson M, Lowe H, Witting P, Allan C, Zhou H; University of Sydney/Major Equipment.

2006

  • Axiovert 200 Fluorescent Microscope Upgrade; Witting P, Lowe H, Seibel M; Clive & Vera Ramaciotti Foundation/General Grants.
  • OPMI Pico Microscope with MORA Interface and Medilive Image box; Witting P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • KODAK Image Station 2000mm Multi-Modal Imager; Seibel M, Nicholson G, Witting P, Le Couteur D, Freedman B, Dunstan C, Blair J, Kennerson M, Myers S, Muller M; University of Sydney/Major Equipment.
  • Cell culture quarantine and storage facility plus assessories; Dunstan C, Witting P, Myers S, Handelsman D, Seibel M, Nicholson G, Zhou H, Kennerson M, Allan C, Freedman B, Le Couteur D, Muller M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2005

  • Investigation of novel neutrophil function & neutrophil-derived fibrinolytic proteases in the plasminogen deficient (PG-/-) mouse; Witting P, Brieger D; University of Sydney/Research & Development.
  • Victor 3 Multi-label Plate Reader; Witting P, Handelsman D, Le Couteur D, Nicholson G, Seibel M, Kril J, Kritharides L, Kennerson M; University of Sydney/Major Equipment.
  • Bio-Rad iCycler iQ5 Real-Time PCR & Mutation detection system; Seibel M, Le Couteur D, Freedman B, Nicholson G, Handelsman D, Kennerson M, Dunstan C, Allan C, Witting P, Kril J, Muller M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2004

  • Start up & research support funding DVC R&I - Dr Witting; Witting P; University of Sydney/Internal Research Grant Allocations.
  • Biochemical properties of S-nitroso-myoglobin and its role in regulating nitric oxide bio-availability; Australian Research Council (ARC)/Discovery Projects (DP).
  • OPTIMAX TLX 120 ultracentrifuge; Witting P, Handelsman D, Nicholson G, Lay P, Kritharides L, Kril J, Le Couteur D, Lowe H, Kennerson M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • The potential role of two-electron oxidation reactions in atherosclerosis; Stocker R, Witting P; Heart Foundation of Australia/Research Support.

Selected publications

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Book Chapters

  • Wang, X., Cai, X., Freedman, B., Witting, P. (2013). Role of SAA in Promoting Endothelial Activation: Inhibition by High-Density Lipoprotein. In Sabina Janciauskiene (Eds.), Acute Phase Proteins, (pp. 77-101). Rijeka, Croatia: InTech Publishers.
  • Neuzil, J., Witting, P., Kontush, A., Headrick, J. (2007). Role of vitamins E and C in nuclear factor-kB and nitric oxide signaling. In Victor R. Preedy, Ronald Ross Watson (Eds.), The Encyclopedia of Vitamin E. United Kingdom: CABI Publishing.
  • Neuzil, J., Witting, P., Kontush, A., Headrick, J. (2006). Role of Vitamin E and Vitamin C in Nuclear Factor-kB-Dependent Nitric Oxide Signalling. In Victor R. Preedy, Ronald Ross Watson (Eds.), The Encyclopedia of Vitamin E, (pp. 339-352). United Kingdom: CABI Publishing.
  • Witting, P., Stocker, R. (2004). Ascorbic Acid in Atherosclerosis. In Han Asard, James May, Nicholas Smirnoff (Eds.), Vitamin C: Its Functions and Biochemistry in Animals and Plants, (pp. 261-290). Oxford: Taylor and Francis.
  • Pettersson, K., Witting, P., Stocker, R. (2000). Antioxidant intervention studies in animals. In RT Dean, D Kelly (Eds.), Atherosclerosis: Gene Expression, Cell Interactions, and Oxidation, (pp. 46-67). Oxford: Oxford University Press.

Journals

  • Hong Duong, T., Chami, B., McMahon, A., Fong, G., Dennis, J., Freedman, B., Witting, P. (2014). Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury. Journal of Neurochemistry, 130(6), 733-747. [More Information]
  • Talib, J., Kwan, J., Suryo Rahmanto, A., Witting, P., Davies, M. (2014). The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction. The Biochemical Journal, 457(1), 89-97. [More Information]
  • Getts, D., Terry, R., Getts, M., Deffrasnes, C., Müller, M., Van Vreden, C., Ashhurst, T., Chami, B., McCarthy, D., Wu, H., Ma, J., Witting, P., Campbell, I., Reilly, D., White, M., Cordwell, S., Chadban, S., Bao, B., King, N., et al (2014). Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine, 6(219), 1-14. [More Information]
  • Weekley, C., Shanu, A., Aitken, J., Vogt, S., Witting, P., Harris, H. (2014). XAS and XFM studies of selenium and copper speciation and distribution in the kidneys of selenite-supplemented rats. Metallomics, 6(9), 1602-1615. [More Information]
  • Weekley, C., Aitken, J., Witting, P., Harris, H. (2014). XAS studies of Se speciation in selenite-fed rats. Metallomics, 6(12), 2193-2203. [More Information]
  • McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013). Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica, 50(4), 645-649. [More Information]
  • Hua, S., Yao, M., Vignarajan, S., Witting, P., Hejazi, L., Gong, Z., Teng, Y., Niknami, M., Assinder, S., Richardson, D., Dong, Q. (2013). Cytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1831 (6), 1146-1157. [More Information]
  • Freewan, M., Rees, M., Sempertegui Plaza, T., Glaros, E., Lim, Y., Wang, X., Yeung, A., Witting, P., Terentis, A., Thomas, S. (2013). Human Indoleamine 2,3-Dioxygenase Is a Catalyst of Physiological Heme Peroxidase Reactions. Journal of Biological Chemistry, 288(3), 1548-1567. [More Information]
  • Sutherland, G., Chami, B., Youssef, P., Witting, P. (2013). Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? Redox Report, 18(4), 134-141. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Shanu, A., Groebler, L., Kim, H., Wood, S., Weekley, C., Aitken, J., Harris, H., Witting, P. (2013). Selenium Inhibits Renal Oxidation and Inflammation But Not Acute Kidney Injury in an Animal Model of Rhabdomyolysis. Antioxidants & Redox Signaling, 18(7), 756-769. [More Information]
  • Weekley, C., Aitken, J., Finney, L., Vogt, S., Witting, P., Harris, H. (2013). Selenium metabolism in cancer cells: The combined application of XAS and XFM techniques to the problem of selenium speciation in biological systems. Nutrients, 5(5), 1734-1756. [More Information]
  • Cai, X., Freedman, B., Witting, P. (2013). Serum amyloid A stimulates cultured endothelial cells to migrate and proliferate: Inhibition by the multi-kinase inhibitor BIBF112. Clinical and Experimental Pharmacology and Physiology, 40(9), 662-670. [More Information]
  • Ding, A., Kalaignanasundaram, P., Ricardo, S., Abdelkader, A., Witting, P., Broughton, B., Kim, H., Wyse, B., Phillips, J., Evans, R. (2012). Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Clinical and Experimental Pharmacology and Physiology, 39(11), 917-929. [More Information]
  • Groebler, L., Wang, X., Kim, H., Shanu, A., Hossain, F., McMahon, A., Witting, P. (2012). Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis. Free Radical Biology and Medicine, 52(9), 1918-1928. [More Information]
  • Aitken, J., Lay, P., Duong, T., Aran, R., Witting, P., Harris, H., Lai, B., Vogt, S., Giles, G. (2012). Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen. Journal of Biological Inorganic Chemistry, 17(4), 589-598. [More Information]
  • Groebler, L., Liu, J., Shanu, A., Codd, R., Witting, P. (2011). Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl) carboxamide in a cell model of myoglobinuria. Biochemical Journal, 435(3), 669-677. [More Information]
  • Weekley, C., Aitken, J., Vogt, S., Finney, L., Paterson, D., De Jonge, M., Howard, D., Witting, P., Musgrave, I., Harris, H. (2011). Metabolism of selenite in human lung cancer cells: X-ray absorption and fluorescence studies. Journal of the American Chemical Society, 133(45), 18272-18279. [More Information]
  • Dong, L., Jameson, V., Tilly, D., Cerny, J., Mahdavian, E., Marín-Hernandez, A., Hernández-Esquivel, L., Rodriguez-Enriquez, S., Stursa, J., Witting, P., et al (2011). Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II. Journal of Biological Chemistry, 286(5), 3717-3728. [More Information]
  • Dong, L., Jameson, V., Tilly, D., Prochazka, L., Rohlena, J., Valis, K., Truksa, J., Zobalova, R., Mahdavian, E., Kluckova, K., Witting, P., et al (2011). Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy. Free Radical Biology and Medicine, 50(11), 1546-1555. [More Information]
  • Kim, H., Shanu, A., Wood, S., Parry, S., McGee-Collett, M., McMahon, A., Witting, P. (2011). Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Free Radical Research, 45(9), 1000-1012. [More Information]
  • Witting, P., Song, C., Hsu, K., Hua, S., Parry, S., Aran, R., Geczy, C., Freedman, B. (2011). The acute-phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein. Free Radical Biology and Medicine, 51(7), 1390-1398. [More Information]
  • Cho, J., Witting, P., Verma, M., Wu, B., Shanu, A., Kairaitis, K., Amis, T., Wheatley, J. (2011). Tissue Vibration Induces Carotid Artery Endothelial Dysfunction: A Mechanism Linking Snoring and Carotid Atherosclerosis? Sleep, 34(6), 751-757C. [More Information]
  • Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010). Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of Biological Inorganic Chemistry, 15(8), 1305-1318. [More Information]
  • Liu, J., Obando Gutierrez, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010). Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of Medicinal Chemistry, 53(3), 1370-1382. [More Information]
  • Niknami, M., Vignarajan, S., Yao, M., Hua, S., Witting, P., Kita, Y., Shimizu, T., Sved, P., Patel, M., Dong, Q. (2010). Decrease in expression or activity of cytosolic phospholipase A(2)alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1801 (7), 731-737. [More Information]
  • Wu, B., Yan, L., Charlton, F., Witting, P., Barter, P., Rye, K. (2010). Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(5), 968-975. [More Information]
  • Wang, Y., Liu, H., McKenzie, G., Witting, P., Stasch, J., Hahn, M., Changsirivathanathamrong, D., Wu, B., Ball, H., Thomas, S., Celermajer, D., Hunt, N., Stocker, R., et al (2010). Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature Medicine, 16(3), 279-285. [More Information]
  • Antao, S., Duong, T., Aran, R., Witting, P. (2010). Neuroglobin Overexpression in Cultured Human Neuronal Cells Protects Against Hydrogen Peroxide Insult via Activating Phosphoinositide-3 Kinase and Opening the Mitochondrial KATP Channel. Antioxidants & Redox Signaling, 13(6), 769-781. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Szuchman-Sapir, A., Pattison, D., Davies, M., Witting, P. (2010). Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b(5)-mediated heme reduction. Free Radical Biology and Medicine, 48(1), 35-46. [More Information]
  • Shanu, A., Parry, S., Wood, S., Rodas, E., Witting, P. (2010). The synthetic polyphenol tert-butyl-bisphenol inhibits myoglobin-induced dysfunction in cultured kidney epithelial cells. Free Radical Research, 44(8), 843-853. [More Information]
  • Hua, S., Song, C., Geczy, C., Freedman, B., Witting, P. (2009). A role for acute-phase serum amyloid A and high-density lipoprotein in oxidative stress, endothelial dysfunction and atherosclerosis. Redox Report, 14(5), 187-196. [More Information]
  • Whiteman, I., Gervasio, O., Cullen, K., Guillemin, G., Jeong, E., Witting, P., Antao, S., Minamide, L., Bamburg, J., Goldsbury, C. (2009). Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. The Journal of Neuroscience, 29(41), 12994-13005. [More Information]
  • Sabaretnam, T., Harris, M., Kockx, M., Witting, P., Le Couteur, D., Kritharides, L. (2009). Effects of hydrogen peroxide and apolipoprotein e isoforms on apolipoprotein e trafficking in HepG2 cells. Clinical and Experimental Pharmacology and Physiology, 36(12), e96-e102. [More Information]
  • Reichelt, M., Shanu, A., Willems, L., Witting, P., Ellis, N., Blackburn, M., Headrick, J. (2009). Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts. Antioxidants & Redox Signaling, 11(11), 2641-2650. [More Information]
  • Niknami, M., Patel, M., Witting, P., Dong, Q. (2009). Molecules in focus: Cytosolic phospholipase A(2)-{alpha}. The International Journal of Biochemistry and Cell Biology, 41(5), 994-997. [More Information]
  • Duong, T., Witting, P., Antao, S., Parry, S., Kennerson, M., Lai, B., Vogt, S., Lay, P., Harris, H. (2009). Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury. Journal of Neurochemistry, 108(5), 1143-1154. [More Information]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009). Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal, 423(2), 169-177. [More Information]
  • Niknami, M., Dong, Q., Witting, P. (2009). Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. Free Radical Research, 43(10), 951-956. [More Information]
  • Song, C., Hsu, K., Yamen, E., Yan, W., Fock, J., Witting, P., Geczy, C., Freedman, B. (2009). Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes. Atherosclerosis, 207(2), 374-383. [More Information]
  • Song, C., Shen, Y., Yamen, E., Hsu, K., Yan, W., Witting, P., Freedman, B., Geczy, C. (2009). Serum amyloid A may potentiate prothrombotic and proinflammatory events in acute coronary syndromes. Atherosclerosis, 202(2), 596-604. [More Information]
  • Dong, L., Freeman, R., Liu, J., Zobalova, R., Marin-Hernandez, A., Stantic, M., Rohlena, J., Valis, K., Rodriguez-Enriques, S., Butcher, B., Witting, P., et al (2009). Suppression of tumor growth in vivo by the mitocan α-tocopheryl succinate requires respiratory complex II. Clinical Cancer Research, 15(5), 1593-1600. [More Information]
  • Niknami, M., Patel, M., Witting, P., Dong, Q. (2008). Aberrant Activation of Arachidonic Acid and Eicosanoid Pathways- Targets for Treating Prostate Cancer. Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, 2(1), 9-15.
  • Dong, L., Low, P., Dyason, J., Wang, X., Prochazka, L., Witting, P., Freeman, R., Swettenham, E., Valis, K., Lu, J., et al (2008). Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene, 27(31), 4324-4335. [More Information]
  • Szuchman-Sapir, A., Pattison, D., Ellis, N., Hawkins, C., Davies, M., Witting, P. (2008). Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin. Free Radical Biology and Medicine, 45(6), 789-798. [More Information]
  • Parry, S., Hamilton (Ellis), N., Li, Z., Maitz, P., Witting, P. (2008). Myoglobin induces oxidative stress and decreases endocytosis and monolayer permissiveness in cultured kidney epithelial cells without affecting viability. Kidney and Blood Pressure Research, 31(1), 16-28. [More Information]
  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]
  • Thomas, S., Witting, P., Drummond, G. (2008). Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxidants & Redox Signaling, 10(10), 1713-1765. [More Information]
  • Duong, T., Antao, S., Hamilton (Ellis), N., Myers, S., Witting, P. (2008). Supplementation with a synthetic polyphenol limits oxidative stress and enhances neuronal cell viability in response to hypoxia-re-oxygenation injury. Brain Research, 1219, 8-18. [More Information]
  • Witting, P., Rayner, B., Wu, B., Ellis, N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Neuzil, J., Widen, C., Gellert, N., Swettenham, E., Zobalova, R., Dong, L., Wang, X., Lidebjer, C., Dalen, H., Headrick, J., Witting, P. (2007). Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury. Redox Report, 12(3), 148-162. [More Information]
  • Dong, L., Swettenham, E., Eliasson, J., Wang, X., Gold, M., Medunic, Y., Stantic, M., Low, P., Prochazka, L., Witting, P., et al (2007). Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress. Cancer Research, 67(24), 11906-11919. [More Information]
  • Wu, B., Kathir, K., Witting, P., Beck, K., Choy, K., Li, C., Croft, K., Mori, T., Tanous, D., Adams, M., Lau, A., Stocker, R. (2006). Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. The Journal of Experimental Medicine, 203(4), 1117-1127. [More Information]
  • Witting, P., Liao, W., Harris, M., Neuzil, J. (2006). Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxide. Biochemical and Biophysical Research Communications, 348(2), 485-493. [More Information]
  • McMahon, A., Hong Duong, T., Brieger, D., Witting, P. (2006). Is there potential for antioxidants to enhance thrombolysis therapy in patients with ischemic stroke? Future Cardiology, 2, 659-665.
  • de Haan, J., Witting, P., Stefanovic, N., Pete, J., Daskalakis, M., Kola, I., Stocker, R., Smolich, J. (2006). Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet. Journal of Lipid Research, 47(6), 1157-1167. [More Information]
  • Hack, B., Witting, P., Rayner, B., Stocker, R., Headrick, J. (2006). Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine. Molecular and Cellular Biochemistry, 287(1-2), 165-175. [More Information]
  • Rayner, B., Hong Duong, T., Myers, S., Witting, P. (2006). Protective effect of a synthetic anti-oxidant on neuronal cell apoptosis resulting from experimental hypoxia re-oxygenation injury. Journal of Neurochemistry, 97(1), 211-221. [More Information]
  • Bhindi, R., Witting, P., McMahon, A., Khachigian, L., Lowe, H. (2006). Rat models of myocardial infarction. Pathogenetic insights and clinical relevance. Thrombosis and Haemostasis, 96(5), 602-610. [More Information]
  • McMahon, A., Duong, T., Brieger, D., Witting, P. (2006). Scope for antioxidants to enhance thrombolytic therapies in stroke patients. Future Cardiology, 2, 659-665.
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]
  • Stapelberg, M., Gellert, N., Swettenham, E., Tomasetti, M., Witting, P., Procopio, A., Neuzil, J. (2005). Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. Journal of Biological Chemistry, 280(27), 25369-25376. [More Information]
  • Swettenham, E., Witting, P., Salvatore, B., Neuzil, J. (2005). Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system? Journal of Neurochemistry, 94(5), 1448-1456. [More Information]
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2005). Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. Journal of Biological Chemistry, 280(11), 9985-9993. [More Information]
  • Neuzil, J., Rayner, B., Lowe, H., Witting, P. (2005). Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research. Redox Report, 10(4), 187-197. [More Information]
  • Witting, P., Wu, B., Raftery, M., Southwell-Keely, P., Stocker, R. (2005). Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate. Journal of Biological Chemistry, 280(16), 15612-15608. [More Information]
  • Wang, X., Witting, P., Salvatore, B., Neuzil, J. (2005). Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway. Biochemical and Biophysical Research Communications, 326(2), 282-289.
  • Deng, Y., Wu, B., Witting, P., Stocker, R. (2004). Probucol protects against smooth muscle cell proliferation by up-regulating heme oxygenase-1. Circulation, 110(13), 1855-1860.
  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2004). Regulation Of Vascular Tone By S-Nitroso-Myoglobin. Redox Report, 9(6), 382-386.
  • Choy, K., Deng, Y., Hou, J., Wu, B., Lau, A., Witting, P., Stocker, R. (2003). Coenzyme Q10 Supplementation Inhibits Aortic Lipid Oxidation but Fails to Attenuate Intimal Thickening in Balloon-Injured New Zealand White Rabbits. Free Radical Biology and Medicine, 35(3), 300-309.
  • Weber, T., Dalen, H., Andera, L., Negre-Salvayre, A., Auge, N., Sticha, M., Loret, A., Terman, A., Witting, P., Higuchi, M., et al (2003). Mitochondria play a central role in apoptosis induced by alpha-Tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. Biochemistry, 42(14), 4277-4291.
  • Brasen, J., Koenig, K., Bach, H., Kontush, A., Heinle, H., Witting, P., Ylä-Herttuala, S., Stocker, R., Beisiegel, U. (2002). Comparison of the effects of α-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits. Atherosclerosis, 163(2), 249-259.
  • Upston, J., Witting, P., Brown, A., Stocker, R., Keaney, J. (2001). Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits. Free Radical Biology and Medicine, 31, 1245-1253.
  • Witting, P., Mauk,, A., Douglas, D., Stocker, R. (2001). Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stress. Biochemical and Biophysical Research Communications, 286, 352-356.
  • Witting, P., Pettersson, K., Letters, J., Stocker, R. (2000). Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice. Free Radical Biology and Medicine, 29, 295-305.
  • Raitakari, O., McCredie, R., Letters, J., Witting, P., Griffiths, K., Sullivan, D., Stocker, R., Celermajer, D. (2000). Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radical Biology and Medicine, 28, 1100-1105.
  • Lau, A., Witting, P., Chaufour, X., Celermajer, D., Pettersson, K., Stocker, R. (2000). Protective effects of probucol in two animal models of atherosclerosis. Redox Report, 5, 116-118.
  • Witting, P., Pettersson, K., Letters, J., Stocker, R. (2000). Site-specific anti-atherogenic effect of probucol in apolipoprotein E deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 20, e26-e33.

Conferences

  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2006). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Raynor, B., Harris, H., Carter, E., Vogt, S., Cai, Z., Lai, B., Chin, C., Lee, Y., Lay, P., Witting, P. (2006). The use of synchrotron radiation to measure ion flux and cellular protein and lipid changes within cardiac ischemia reperfusion injury. XIV International Symposium on Atherosclerosis, Ireland: Elsevier Ireland Ltd.
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2005). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.

2014

  • Hong Duong, T., Chami, B., McMahon, A., Fong, G., Dennis, J., Freedman, B., Witting, P. (2014). Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury. Journal of Neurochemistry, 130(6), 733-747. [More Information]
  • Talib, J., Kwan, J., Suryo Rahmanto, A., Witting, P., Davies, M. (2014). The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction. The Biochemical Journal, 457(1), 89-97. [More Information]
  • Getts, D., Terry, R., Getts, M., Deffrasnes, C., Müller, M., Van Vreden, C., Ashhurst, T., Chami, B., McCarthy, D., Wu, H., Ma, J., Witting, P., Campbell, I., Reilly, D., White, M., Cordwell, S., Chadban, S., Bao, B., King, N., et al (2014). Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine, 6(219), 1-14. [More Information]
  • Weekley, C., Shanu, A., Aitken, J., Vogt, S., Witting, P., Harris, H. (2014). XAS and XFM studies of selenium and copper speciation and distribution in the kidneys of selenite-supplemented rats. Metallomics, 6(9), 1602-1615. [More Information]
  • Weekley, C., Aitken, J., Witting, P., Harris, H. (2014). XAS studies of Se speciation in selenite-fed rats. Metallomics, 6(12), 2193-2203. [More Information]

2013

  • McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013). Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica, 50(4), 645-649. [More Information]
  • Hua, S., Yao, M., Vignarajan, S., Witting, P., Hejazi, L., Gong, Z., Teng, Y., Niknami, M., Assinder, S., Richardson, D., Dong, Q. (2013). Cytosolic phospholipase A2alpha sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1831 (6), 1146-1157. [More Information]
  • Freewan, M., Rees, M., Sempertegui Plaza, T., Glaros, E., Lim, Y., Wang, X., Yeung, A., Witting, P., Terentis, A., Thomas, S. (2013). Human Indoleamine 2,3-Dioxygenase Is a Catalyst of Physiological Heme Peroxidase Reactions. Journal of Biological Chemistry, 288(3), 1548-1567. [More Information]
  • Sutherland, G., Chami, B., Youssef, P., Witting, P. (2013). Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? Redox Report, 18(4), 134-141. [More Information]
  • Wang, X., Cai, X., Freedman, B., Witting, P. (2013). Role of SAA in Promoting Endothelial Activation: Inhibition by High-Density Lipoprotein. In Sabina Janciauskiene (Eds.), Acute Phase Proteins, (pp. 77-101). Rijeka, Croatia: InTech Publishers.
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Shanu, A., Groebler, L., Kim, H., Wood, S., Weekley, C., Aitken, J., Harris, H., Witting, P. (2013). Selenium Inhibits Renal Oxidation and Inflammation But Not Acute Kidney Injury in an Animal Model of Rhabdomyolysis. Antioxidants & Redox Signaling, 18(7), 756-769. [More Information]
  • Weekley, C., Aitken, J., Finney, L., Vogt, S., Witting, P., Harris, H. (2013). Selenium metabolism in cancer cells: The combined application of XAS and XFM techniques to the problem of selenium speciation in biological systems. Nutrients, 5(5), 1734-1756. [More Information]
  • Cai, X., Freedman, B., Witting, P. (2013). Serum amyloid A stimulates cultured endothelial cells to migrate and proliferate: Inhibition by the multi-kinase inhibitor BIBF112. Clinical and Experimental Pharmacology and Physiology, 40(9), 662-670. [More Information]

2012

  • Ding, A., Kalaignanasundaram, P., Ricardo, S., Abdelkader, A., Witting, P., Broughton, B., Kim, H., Wyse, B., Phillips, J., Evans, R. (2012). Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Clinical and Experimental Pharmacology and Physiology, 39(11), 917-929. [More Information]
  • Groebler, L., Wang, X., Kim, H., Shanu, A., Hossain, F., McMahon, A., Witting, P. (2012). Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis. Free Radical Biology and Medicine, 52(9), 1918-1928. [More Information]
  • Aitken, J., Lay, P., Duong, T., Aran, R., Witting, P., Harris, H., Lai, B., Vogt, S., Giles, G. (2012). Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen. Journal of Biological Inorganic Chemistry, 17(4), 589-598. [More Information]

2011

  • Groebler, L., Liu, J., Shanu, A., Codd, R., Witting, P. (2011). Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl) carboxamide in a cell model of myoglobinuria. Biochemical Journal, 435(3), 669-677. [More Information]
  • Weekley, C., Aitken, J., Vogt, S., Finney, L., Paterson, D., De Jonge, M., Howard, D., Witting, P., Musgrave, I., Harris, H. (2011). Metabolism of selenite in human lung cancer cells: X-ray absorption and fluorescence studies. Journal of the American Chemical Society, 133(45), 18272-18279. [More Information]
  • Dong, L., Jameson, V., Tilly, D., Cerny, J., Mahdavian, E., Marín-Hernandez, A., Hernández-Esquivel, L., Rodriguez-Enriquez, S., Stursa, J., Witting, P., et al (2011). Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II. Journal of Biological Chemistry, 286(5), 3717-3728. [More Information]
  • Dong, L., Jameson, V., Tilly, D., Prochazka, L., Rohlena, J., Valis, K., Truksa, J., Zobalova, R., Mahdavian, E., Kluckova, K., Witting, P., et al (2011). Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy. Free Radical Biology and Medicine, 50(11), 1546-1555. [More Information]
  • Kim, H., Shanu, A., Wood, S., Parry, S., McGee-Collett, M., McMahon, A., Witting, P. (2011). Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Free Radical Research, 45(9), 1000-1012. [More Information]
  • Witting, P., Song, C., Hsu, K., Hua, S., Parry, S., Aran, R., Geczy, C., Freedman, B. (2011). The acute-phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein. Free Radical Biology and Medicine, 51(7), 1390-1398. [More Information]
  • Cho, J., Witting, P., Verma, M., Wu, B., Shanu, A., Kairaitis, K., Amis, T., Wheatley, J. (2011). Tissue Vibration Induces Carotid Artery Endothelial Dysfunction: A Mechanism Linking Snoring and Carotid Atherosclerosis? Sleep, 34(6), 751-757C. [More Information]

2010

  • Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010). Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of Biological Inorganic Chemistry, 15(8), 1305-1318. [More Information]
  • Liu, J., Obando Gutierrez, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010). Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of Medicinal Chemistry, 53(3), 1370-1382. [More Information]
  • Niknami, M., Vignarajan, S., Yao, M., Hua, S., Witting, P., Kita, Y., Shimizu, T., Sved, P., Patel, M., Dong, Q. (2010). Decrease in expression or activity of cytosolic phospholipase A(2)alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1801 (7), 731-737. [More Information]
  • Wu, B., Yan, L., Charlton, F., Witting, P., Barter, P., Rye, K. (2010). Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(5), 968-975. [More Information]
  • Wang, Y., Liu, H., McKenzie, G., Witting, P., Stasch, J., Hahn, M., Changsirivathanathamrong, D., Wu, B., Ball, H., Thomas, S., Celermajer, D., Hunt, N., Stocker, R., et al (2010). Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature Medicine, 16(3), 279-285. [More Information]
  • Antao, S., Duong, T., Aran, R., Witting, P. (2010). Neuroglobin Overexpression in Cultured Human Neuronal Cells Protects Against Hydrogen Peroxide Insult via Activating Phosphoinositide-3 Kinase and Opening the Mitochondrial KATP Channel. Antioxidants & Redox Signaling, 13(6), 769-781. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Szuchman-Sapir, A., Pattison, D., Davies, M., Witting, P. (2010). Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b(5)-mediated heme reduction. Free Radical Biology and Medicine, 48(1), 35-46. [More Information]
  • Shanu, A., Parry, S., Wood, S., Rodas, E., Witting, P. (2010). The synthetic polyphenol tert-butyl-bisphenol inhibits myoglobin-induced dysfunction in cultured kidney epithelial cells. Free Radical Research, 44(8), 843-853. [More Information]

2009

  • Hua, S., Song, C., Geczy, C., Freedman, B., Witting, P. (2009). A role for acute-phase serum amyloid A and high-density lipoprotein in oxidative stress, endothelial dysfunction and atherosclerosis. Redox Report, 14(5), 187-196. [More Information]
  • Whiteman, I., Gervasio, O., Cullen, K., Guillemin, G., Jeong, E., Witting, P., Antao, S., Minamide, L., Bamburg, J., Goldsbury, C. (2009). Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. The Journal of Neuroscience, 29(41), 12994-13005. [More Information]
  • Sabaretnam, T., Harris, M., Kockx, M., Witting, P., Le Couteur, D., Kritharides, L. (2009). Effects of hydrogen peroxide and apolipoprotein e isoforms on apolipoprotein e trafficking in HepG2 cells. Clinical and Experimental Pharmacology and Physiology, 36(12), e96-e102. [More Information]
  • Reichelt, M., Shanu, A., Willems, L., Witting, P., Ellis, N., Blackburn, M., Headrick, J. (2009). Endogenous adenosine selectively modulates oxidant stress via the A1 receptor in ischemic hearts. Antioxidants & Redox Signaling, 11(11), 2641-2650. [More Information]
  • Niknami, M., Patel, M., Witting, P., Dong, Q. (2009). Molecules in focus: Cytosolic phospholipase A(2)-{alpha}. The International Journal of Biochemistry and Cell Biology, 41(5), 994-997. [More Information]
  • Duong, T., Witting, P., Antao, S., Parry, S., Kennerson, M., Lai, B., Vogt, S., Lay, P., Harris, H. (2009). Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury. Journal of Neurochemistry, 108(5), 1143-1154. [More Information]
  • Rayner, B., Hua, S., Sabaretnam, T., Witting, P. (2009). Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle. Biochemical Journal, 423(2), 169-177. [More Information]
  • Niknami, M., Dong, Q., Witting, P. (2009). Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. Free Radical Research, 43(10), 951-956. [More Information]
  • Song, C., Hsu, K., Yamen, E., Yan, W., Fock, J., Witting, P., Geczy, C., Freedman, B. (2009). Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes. Atherosclerosis, 207(2), 374-383. [More Information]
  • Song, C., Shen, Y., Yamen, E., Hsu, K., Yan, W., Witting, P., Freedman, B., Geczy, C. (2009). Serum amyloid A may potentiate prothrombotic and proinflammatory events in acute coronary syndromes. Atherosclerosis, 202(2), 596-604. [More Information]
  • Dong, L., Freeman, R., Liu, J., Zobalova, R., Marin-Hernandez, A., Stantic, M., Rohlena, J., Valis, K., Rodriguez-Enriques, S., Butcher, B., Witting, P., et al (2009). Suppression of tumor growth in vivo by the mitocan α-tocopheryl succinate requires respiratory complex II. Clinical Cancer Research, 15(5), 1593-1600. [More Information]

2008

  • Niknami, M., Patel, M., Witting, P., Dong, Q. (2008). Aberrant Activation of Arachidonic Acid and Eicosanoid Pathways- Targets for Treating Prostate Cancer. Recent Patents on Endocrine, Metabolic and Immune Drug Discovery, 2(1), 9-15.
  • Dong, L., Low, P., Dyason, J., Wang, X., Prochazka, L., Witting, P., Freeman, R., Swettenham, E., Valis, K., Lu, J., et al (2008). Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene, 27(31), 4324-4335. [More Information]
  • Szuchman-Sapir, A., Pattison, D., Ellis, N., Hawkins, C., Davies, M., Witting, P. (2008). Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin. Free Radical Biology and Medicine, 45(6), 789-798. [More Information]
  • Parry, S., Hamilton (Ellis), N., Li, Z., Maitz, P., Witting, P. (2008). Myoglobin induces oxidative stress and decreases endocytosis and monolayer permissiveness in cultured kidney epithelial cells without affecting viability. Kidney and Blood Pressure Research, 31(1), 16-28. [More Information]
  • Witting, P., Zeng, B., Wong, M., McMahon, A., Rayner, B., Sapir, A., Lowe, H., Freedman, B., Brieger, D. (2008). Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice. Thrombosis Research, 122(5), 674-682. [More Information]
  • Thomas, S., Witting, P., Drummond, G. (2008). Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxidants & Redox Signaling, 10(10), 1713-1765. [More Information]
  • Duong, T., Antao, S., Hamilton (Ellis), N., Myers, S., Witting, P. (2008). Supplementation with a synthetic polyphenol limits oxidative stress and enhances neuronal cell viability in response to hypoxia-re-oxygenation injury. Brain Research, 1219, 8-18. [More Information]

2007

  • Witting, P., Rayner, B., Wu, B., Ellis, N., Stocker, R. (2007). Hydrogen peroxide promotes endothelial dysfunction by stimulating multiple sources of superoxide anion radical production and decreasing nitric oxide bioavailability. Cellular Physiology and Biochemistry, 20(5), 255-268. [More Information]
  • Neuzil, J., Widen, C., Gellert, N., Swettenham, E., Zobalova, R., Dong, L., Wang, X., Lidebjer, C., Dalen, H., Headrick, J., Witting, P. (2007). Mitochondria transmit apoptosis signalling in cardiomyocyte-like cells and isolated hearts exposed to experimental ischemia-reperfusion injury. Redox Report, 12(3), 148-162. [More Information]
  • Neuzil, J., Witting, P., Kontush, A., Headrick, J. (2007). Role of vitamins E and C in nuclear factor-kB and nitric oxide signaling. In Victor R. Preedy, Ronald Ross Watson (Eds.), The Encyclopedia of Vitamin E. United Kingdom: CABI Publishing.
  • Dong, L., Swettenham, E., Eliasson, J., Wang, X., Gold, M., Medunic, Y., Stantic, M., Low, P., Prochazka, L., Witting, P., et al (2007). Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress. Cancer Research, 67(24), 11906-11919. [More Information]

2006

  • Wu, B., Kathir, K., Witting, P., Beck, K., Choy, K., Li, C., Croft, K., Mori, T., Tanous, D., Adams, M., Lau, A., Stocker, R. (2006). Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. The Journal of Experimental Medicine, 203(4), 1117-1127. [More Information]
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2006). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Witting, P., Liao, W., Harris, M., Neuzil, J. (2006). Expression of human myoglobin in H9c2 cells enhances toxicity to added hydrogen peroxide. Biochemical and Biophysical Research Communications, 348(2), 485-493. [More Information]
  • McMahon, A., Hong Duong, T., Brieger, D., Witting, P. (2006). Is there potential for antioxidants to enhance thrombolysis therapy in patients with ischemic stroke? Future Cardiology, 2, 659-665.
  • de Haan, J., Witting, P., Stefanovic, N., Pete, J., Daskalakis, M., Kola, I., Stocker, R., Smolich, J. (2006). Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet. Journal of Lipid Research, 47(6), 1157-1167. [More Information]
  • Hack, B., Witting, P., Rayner, B., Stocker, R., Headrick, J. (2006). Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine. Molecular and Cellular Biochemistry, 287(1-2), 165-175. [More Information]
  • Rayner, B., Hong Duong, T., Myers, S., Witting, P. (2006). Protective effect of a synthetic anti-oxidant on neuronal cell apoptosis resulting from experimental hypoxia re-oxygenation injury. Journal of Neurochemistry, 97(1), 211-221. [More Information]
  • Bhindi, R., Witting, P., McMahon, A., Khachigian, L., Lowe, H. (2006). Rat models of myocardial infarction. Pathogenetic insights and clinical relevance. Thrombosis and Haemostasis, 96(5), 602-610. [More Information]
  • Neuzil, J., Witting, P., Kontush, A., Headrick, J. (2006). Role of Vitamin E and Vitamin C in Nuclear Factor-kB-Dependent Nitric Oxide Signalling. In Victor R. Preedy, Ronald Ross Watson (Eds.), The Encyclopedia of Vitamin E, (pp. 339-352). United Kingdom: CABI Publishing.
  • McMahon, A., Duong, T., Brieger, D., Witting, P. (2006). Scope for antioxidants to enhance thrombolytic therapies in stroke patients. Future Cardiology, 2, 659-665.
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]
  • Raynor, B., Harris, H., Carter, E., Vogt, S., Cai, Z., Lai, B., Chin, C., Lee, Y., Lay, P., Witting, P. (2006). The use of synchrotron radiation to measure ion flux and cellular protein and lipid changes within cardiac ischemia reperfusion injury. XIV International Symposium on Atherosclerosis, Ireland: Elsevier Ireland Ltd.

2005

  • Stapelberg, M., Gellert, N., Swettenham, E., Tomasetti, M., Witting, P., Procopio, A., Neuzil, J. (2005). Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. Journal of Biological Chemistry, 280(27), 25369-25376. [More Information]
  • Swettenham, E., Witting, P., Salvatore, B., Neuzil, J. (2005). Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system? Journal of Neurochemistry, 94(5), 1448-1456. [More Information]
  • Hamilton (Ellis), N., Raftery, M., Rayner, B., Witting, P. (2005). Characterizing a novel biomarker of myocardial inflammation. Society of Free Radical Research, Australia: Society of Free Radical Research.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2005). Human S-nitroso oxymyoglobin is a store of vasoactive nitric oxide. Journal of Biological Chemistry, 280(11), 9985-9993. [More Information]
  • Neuzil, J., Rayner, B., Lowe, H., Witting, P. (2005). Oxidative stress in myocardial ischaemia reperfusion injury: a renewed focus on a long-standing area of heart research. Redox Report, 10(4), 187-197. [More Information]
  • Witting, P., Wu, B., Raftery, M., Southwell-Keely, P., Stocker, R. (2005). Probucol protects against hypochlorite-induced endothelial dysfunction: identification of a novel pathway of probucol oxidation to a biologically active intermediate. Journal of Biological Chemistry, 280(16), 15612-15608. [More Information]
  • Wang, X., Witting, P., Salvatore, B., Neuzil, J. (2005). Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway. Biochemical and Biophysical Research Communications, 326(2), 282-289.

2004

  • Witting, P., Stocker, R. (2004). Ascorbic Acid in Atherosclerosis. In Han Asard, James May, Nicholas Smirnoff (Eds.), Vitamin C: Its Functions and Biochemistry in Animals and Plants, (pp. 261-290). Oxford: Taylor and Francis.
  • Deng, Y., Wu, B., Witting, P., Stocker, R. (2004). Probucol protects against smooth muscle cell proliferation by up-regulating heme oxygenase-1. Circulation, 110(13), 1855-1860.
  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372.
  • Rayner, B., Wu, B., Raftery, M., Stocker, R., Witting, P. (2004). Regulation Of Vascular Tone By S-Nitroso-Myoglobin. Redox Report, 9(6), 382-386.

2003

  • Choy, K., Deng, Y., Hou, J., Wu, B., Lau, A., Witting, P., Stocker, R. (2003). Coenzyme Q10 Supplementation Inhibits Aortic Lipid Oxidation but Fails to Attenuate Intimal Thickening in Balloon-Injured New Zealand White Rabbits. Free Radical Biology and Medicine, 35(3), 300-309.
  • Weber, T., Dalen, H., Andera, L., Negre-Salvayre, A., Auge, N., Sticha, M., Loret, A., Terman, A., Witting, P., Higuchi, M., et al (2003). Mitochondria play a central role in apoptosis induced by alpha-Tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. Biochemistry, 42(14), 4277-4291.

2002

  • Brasen, J., Koenig, K., Bach, H., Kontush, A., Heinle, H., Witting, P., Ylä-Herttuala, S., Stocker, R., Beisiegel, U. (2002). Comparison of the effects of α-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits. Atherosclerosis, 163(2), 249-259.

2001

  • Upston, J., Witting, P., Brown, A., Stocker, R., Keaney, J. (2001). Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits. Free Radical Biology and Medicine, 31, 1245-1253.
  • Witting, P., Mauk,, A., Douglas, D., Stocker, R. (2001). Reaction of human myoglobin and peroxynitrite: characterizing biomarkers for myoglobin-derived oxidative stress. Biochemical and Biophysical Research Communications, 286, 352-356.

2000

  • Witting, P., Pettersson, K., Letters, J., Stocker, R. (2000). Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice. Free Radical Biology and Medicine, 29, 295-305.
  • Pettersson, K., Witting, P., Stocker, R. (2000). Antioxidant intervention studies in animals. In RT Dean, D Kelly (Eds.), Atherosclerosis: Gene Expression, Cell Interactions, and Oxidation, (pp. 46-67). Oxford: Oxford University Press.
  • Raitakari, O., McCredie, R., Letters, J., Witting, P., Griffiths, K., Sullivan, D., Stocker, R., Celermajer, D. (2000). Coenzyme Q improves LDL resistance to ex vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults. Free Radical Biology and Medicine, 28, 1100-1105.
  • Lau, A., Witting, P., Chaufour, X., Celermajer, D., Pettersson, K., Stocker, R. (2000). Protective effects of probucol in two animal models of atherosclerosis. Redox Report, 5, 116-118.
  • Witting, P., Pettersson, K., Letters, J., Stocker, R. (2000). Site-specific anti-atherogenic effect of probucol in apolipoprotein E deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 20, e26-e33.

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