Dr Paul Wrigley

Senior Lecturer
Pain Medicine, Northern Clinical School
Pain Management & Research Institute

Telephone +61 2 9926 4958
Fax +61 2 9463 1050

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Biographical details

Dr Paul Wrigley is a Conjoint Senior Lecturer and Senior Staff Specialist in Pain Medicine at the University of Sydney and the Royal North Shore Hospital, Sydney. He has trained in Anaesthesia (1999) and Pain Medicine (2000) and completed a basic science PhD in neuropharmacology (2007). Alongside his Pain Medicine clinical practice he maintains an active translational clinical neurophysiology research program (2005-). He has received numerous awards for research and clinical practice in Pain Medicine and serves on a number of local and national committees concerned with pain education and delivery of service. He is recognised for his expertise in pain following spinal cord injury however his research more broadly aims to improve the overall clinical assessment and management of chronic pain.

Research interests

Sensory neurophysiology focusing on nociception (Quantitative Sensory Testing, nociceptive withdrawal reflex testing, nociceptive cortical evoked potentials)

Spinal cord injury pain particularly neuropathic pain.

Central neuroimaging (MRI and MRS)

Teaching and supervision

Pain Medicine

Selected grants

2012

  • Neurophysiological assessment of residual thermonociceptive sensation following spinal cord injury - a pilot study; Wrigley P, Siddall P; Australian and New Zealand College of Anaesthetists/Research Project Grant.

2010

  • Regional changes in cerebral pefusion associated with persisent spinal cord injury neuropathic pain; Wrigley P, Henderson L, Siddall P; Australian and New Zealand College of Anaesthetists/Research Grants.

2008

  • Cortical and fibre tract changes in subjects with neuropathic pain following spinal cord injury; Wrigley P, Henderson L, Siddall P; Australian and New Zealand College of Anaesthetists/Research Grants.

2007

  • Development of an Australian spinal cord injury pain research data base; Wrigley P; Australian and New Zealand College of Anaesthetists/Research Grants.
  • Structural alterations of the human brain following complete spinal cord injury in people with and without neuropathic pain - a pilot study; Wrigley P; Pfizer Neuro Science Res Grants/Research Grant.

2004

  • Pfizer Neuroscience Grant; Wrigley P; Pfizer/Neuroscience Grant.

2002

  • Postgraduate Research Support Scheme Grant; Wrigley P; University of Sydney/Postgraduate Research Support Scheme Grant.
  • ANZCA Research Grant; Wrigley P, Vaughan C; ANZ Coll Anaesthetists (ANZCA)/Research Funding Scheme.

Selected publications

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Books

  • Wrigley, P. (2010). Cold Thermal Processing in the Spinal Cord: In Search of Therapeutic Targets for Cold Hyperesthesia. Saarbrucken: VDM Verlag Dr Muller.
  • Wrigley, P., Working Party, W. (2005). Acute Pain Management: Scientific Evidence. Melbourne: Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine.

Book Chapters

  • Siddall, P., Wrigley, P. (2010). Pain Following Spinal Cord Injury. In Scott Fishman, Jane Ballantyne, and James Rathmell (Eds.), Bonicas Management of Pain, (pp. 526-536). Baltimore: Lippincott Williams & Wilkins.
  • Wrigley, P., Siddall, P. (2010). The Clinical Evaluation of Pain. In Siu Lun Tsui et.al (Eds.), Pain Medicine: A Multidisciplinary Approach, (pp. 31-48). Hong Kong: Hong Kong University Press.
  • Siddall, P., Wrigley, P. (2008). Spinal cord injury. In Rice, A., Howard, R.F., Justins, D.M., Miaskowski, C.A. & Newton-John, T (Eds.), Clinical Pain Management: 4 Volume Set, (pp. 388-404). London: Hodder Arnold.
  • Siddall, P., Wrigley, P. (2008). Spinal cord injury. In Peter Wilson, Troels Jensen, Paul Watson and Jennifer A Haythornthwaite (Eds.), Clinical Pain Management: Chronic Pain, (pp. 388-404). London: Hodder Arnold.

Journals

  • Gustin, S., Wrigley, P., Youssef, A., McIndoe, L., Wilcox, S., Rae, C., Edden, R., Siddall, P., Henderson, L. (2014). Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury. Pain, 155(5), 1027-1036. [More Information]
  • Wrigley, P., Gustin, S., McIndoe, L., Chakiath, R., Henderson, L., Siddall, P. (2013). Longstanding neuropathic pain after spinal cord injury is refractory to transcranial direct current stimulation: A randomized controlled trial. Pain, 154(10), 2178-2184. [More Information]
  • Wang, D., Somogyi, A., Yee, B., Wong, K., Kaur, J., Wrigley, P., Grunstein, R. (2013). The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea. Respiratory Physiology and Neurobiology, 185(3), 526-532. [More Information]
  • Henderson, L., Gustin, S., Macey, P., Wrigley, P., Siddall, P. (2011). Functional Reorganization of the Brain in Humans Following Spinal Cord Injury: Evidence for Underlying Changes in Cortical Anatomy. The Journal of Neuroscience, 31(7), 2630-2637. [More Information]
  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2010). Brain Anatomy Changes Associated with Persistent Neuropathic Pain Following Spinal Cord Injury. Cerebral Cortex, 20(6), 1409-1419. [More Information]
  • Gustin, S., Wrigley, P., Henderson, L., Siddall, P. (2010). Brain circuitry underlying pain in response to imagined movement in people with spinal cord injury. Pain, 148(3), 438-445. [More Information]
  • Wrigley, P., Jeong, H., Vaughan, C. (2010). Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn. Molecular Pain, 6(1), 1-10. [More Information]
  • Wrigley, P., Gustin, S., Macey, P., Nash, P., Gandevia, S., Macefield, V., Siddall, P., Henderson, L. (2009). Anatomical Changes in Human Motor Cortex and Motor Pathways following Complete Thoracic Spinal Cord Injury. Cerebral Cortex, 19, 224-232. [More Information]
  • Wrigley, P., Press, S., Gustin, S., Macefield, V., Gandevia, S., Cousins, M., Middleton, J., Henderson, L., Siddall, P. (2009). Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. Pain, 141(1-2), 52-59. [More Information]
  • Wrigley, P., Jeong, H., Vaughan, C. (2009). Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurons. British Journal of Pharmacology, 157, 371-380. [More Information]
  • Wrigley, P., Cousins, M. (2008). Postherpetic neuralgia an update on management and prevention. Medicine Today, 9(4), 36-44.
  • Gustin, S., Wrigley, P., Gandevia, S., Middleton, J., Henderson, L., Siddall, P. (2007). Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury. Pain, 137(2), 237-244. [More Information]
  • Wrigley, P., Siddall, P. (2007). Pharmacological Interventions for Neuropathic Pain Following Spinal Cord Injury: An Update. Topics in Spinal Cord Injury Rehabilitation, 13(2), 58-71. [More Information]
  • Wrigley, P., Gustin, S., Nash, P., Macefield, V., Gandevia, S., Middleton, J., Siddall, P., Henderson, L. (2007). Structural changes associated with pain in spinal cord injured patients. European Journal of Pain, 11(1, Supplement 1), 97-98.
  • Smeal, W., Yezierski, R., Wrigley, P., Siddall, P., Jensen, M., Ehde, D. (2006). Spinal cord injury. The Journal of Pain, 7(12), 871-877.
  • Wrigley, P., Elliott, D., Blake, D. (1998). A Phase 2 Clinical Trial Comparing Ro 48-6791, a New Short-Acting Benzodiazepine, with Propofol for Induction of Anaesthesia. Anaesthesia and Intensive Care, 26(5), 509-514.

Conferences

  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2009). Brain Anatomy Changes Associated With Chronic Neuropathic Pain Following Spinal Cord Injury. ANZCA Annual Scientific Meeting 2009, New Zealand: Australian and New Zealand College of Anaesthetists.
  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2008). Changes in brain activity during mental allodynia. IASP 12th World Congress on Pain, United Kingdom: Elsevier.
  • Wrigley, P., Press, S., Gustin, S., Gandevia, S., Middleton, J., Cousins, M., Henderson, L., Siddall, P. (2008). Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. IASP 12th World Congress on Pain, United Kingdom: Elsevier.
  • Gustin, S., Wrigley, P., Nash, P., Macefield, V., Gandevia, S., Cousins, M., Henderson, L., Siddall, P. (2007). Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury. The Second International Congress on Neuropathic Pain (NeuPSIG), on line: Elsevier.
  • Wrigley, P., Vaughan, C. (2005). Spinal mechanisms of thermal nociceptive processing. International Association for the Study of Pain (IASP) 11th World Congress on Pain, 2005, Australia: International Association for the Study of Pain Press.
  • Wrigley, P., Vaughan, C. (2002). Cold afferent inputs activate a subpopulation of rat dorsal horn neurons in vitro. Australian Neuroscience Society Annual Meeting, Australia: British Medical Journal Publishing Group.
  • Wrigley, P., Vaughan, C. (2002). Spinal cord processing of nociceptive inputs. University of Technology Sydney XIXth Scientific Research Meeting/University of Technology Sydney XIXth Scientific Research Meeting.

Magazine / Newspaper Articles

  • Wrigley, P., McCulloch, T. (2002). Complementary Medicine and Pain Medicine. The Australian Pain Society Newsletter.

2014

  • Gustin, S., Wrigley, P., Youssef, A., McIndoe, L., Wilcox, S., Rae, C., Edden, R., Siddall, P., Henderson, L. (2014). Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury. Pain, 155(5), 1027-1036. [More Information]

2013

  • Wrigley, P., Gustin, S., McIndoe, L., Chakiath, R., Henderson, L., Siddall, P. (2013). Longstanding neuropathic pain after spinal cord injury is refractory to transcranial direct current stimulation: A randomized controlled trial. Pain, 154(10), 2178-2184. [More Information]
  • Wang, D., Somogyi, A., Yee, B., Wong, K., Kaur, J., Wrigley, P., Grunstein, R. (2013). The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea. Respiratory Physiology and Neurobiology, 185(3), 526-532. [More Information]

2011

  • Henderson, L., Gustin, S., Macey, P., Wrigley, P., Siddall, P. (2011). Functional Reorganization of the Brain in Humans Following Spinal Cord Injury: Evidence for Underlying Changes in Cortical Anatomy. The Journal of Neuroscience, 31(7), 2630-2637. [More Information]

2010

  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2010). Brain Anatomy Changes Associated with Persistent Neuropathic Pain Following Spinal Cord Injury. Cerebral Cortex, 20(6), 1409-1419. [More Information]
  • Gustin, S., Wrigley, P., Henderson, L., Siddall, P. (2010). Brain circuitry underlying pain in response to imagined movement in people with spinal cord injury. Pain, 148(3), 438-445. [More Information]
  • Wrigley, P. (2010). Cold Thermal Processing in the Spinal Cord: In Search of Therapeutic Targets for Cold Hyperesthesia. Saarbrucken: VDM Verlag Dr Muller.
  • Wrigley, P., Jeong, H., Vaughan, C. (2010). Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn. Molecular Pain, 6(1), 1-10. [More Information]
  • Siddall, P., Wrigley, P. (2010). Pain Following Spinal Cord Injury. In Scott Fishman, Jane Ballantyne, and James Rathmell (Eds.), Bonicas Management of Pain, (pp. 526-536). Baltimore: Lippincott Williams & Wilkins.
  • Wrigley, P., Siddall, P. (2010). The Clinical Evaluation of Pain. In Siu Lun Tsui et.al (Eds.), Pain Medicine: A Multidisciplinary Approach, (pp. 31-48). Hong Kong: Hong Kong University Press.

2009

  • Wrigley, P., Gustin, S., Macey, P., Nash, P., Gandevia, S., Macefield, V., Siddall, P., Henderson, L. (2009). Anatomical Changes in Human Motor Cortex and Motor Pathways following Complete Thoracic Spinal Cord Injury. Cerebral Cortex, 19, 224-232. [More Information]
  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2009). Brain Anatomy Changes Associated With Chronic Neuropathic Pain Following Spinal Cord Injury. ANZCA Annual Scientific Meeting 2009, New Zealand: Australian and New Zealand College of Anaesthetists.
  • Wrigley, P., Press, S., Gustin, S., Macefield, V., Gandevia, S., Cousins, M., Middleton, J., Henderson, L., Siddall, P. (2009). Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. Pain, 141(1-2), 52-59. [More Information]
  • Wrigley, P., Jeong, H., Vaughan, C. (2009). Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurons. British Journal of Pharmacology, 157, 371-380. [More Information]

2008

  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2008). Changes in brain activity during mental allodynia. IASP 12th World Congress on Pain, United Kingdom: Elsevier.
  • Wrigley, P., Press, S., Gustin, S., Gandevia, S., Middleton, J., Cousins, M., Henderson, L., Siddall, P. (2008). Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. IASP 12th World Congress on Pain, United Kingdom: Elsevier.
  • Wrigley, P., Cousins, M. (2008). Postherpetic neuralgia an update on management and prevention. Medicine Today, 9(4), 36-44.
  • Siddall, P., Wrigley, P. (2008). Spinal cord injury. In Rice, A., Howard, R.F., Justins, D.M., Miaskowski, C.A. & Newton-John, T (Eds.), Clinical Pain Management: 4 Volume Set, (pp. 388-404). London: Hodder Arnold.
  • Siddall, P., Wrigley, P. (2008). Spinal cord injury. In Peter Wilson, Troels Jensen, Paul Watson and Jennifer A Haythornthwaite (Eds.), Clinical Pain Management: Chronic Pain, (pp. 388-404). London: Hodder Arnold.

2007

  • Gustin, S., Wrigley, P., Gandevia, S., Middleton, J., Henderson, L., Siddall, P. (2007). Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury. Pain, 137(2), 237-244. [More Information]
  • Gustin, S., Wrigley, P., Nash, P., Macefield, V., Gandevia, S., Cousins, M., Henderson, L., Siddall, P. (2007). Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury. The Second International Congress on Neuropathic Pain (NeuPSIG), on line: Elsevier.
  • Wrigley, P., Siddall, P. (2007). Pharmacological Interventions for Neuropathic Pain Following Spinal Cord Injury: An Update. Topics in Spinal Cord Injury Rehabilitation, 13(2), 58-71. [More Information]
  • Wrigley, P., Gustin, S., Nash, P., Macefield, V., Gandevia, S., Middleton, J., Siddall, P., Henderson, L. (2007). Structural changes associated with pain in spinal cord injured patients. European Journal of Pain, 11(1, Supplement 1), 97-98.

2006

  • Smeal, W., Yezierski, R., Wrigley, P., Siddall, P., Jensen, M., Ehde, D. (2006). Spinal cord injury. The Journal of Pain, 7(12), 871-877.

2005

  • Wrigley, P., Working Party, W. (2005). Acute Pain Management: Scientific Evidence. Melbourne: Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine.
  • Wrigley, P., Vaughan, C. (2005). Spinal mechanisms of thermal nociceptive processing. International Association for the Study of Pain (IASP) 11th World Congress on Pain, 2005, Australia: International Association for the Study of Pain Press.

2002

  • Wrigley, P., Vaughan, C. (2002). Cold afferent inputs activate a subpopulation of rat dorsal horn neurons in vitro. Australian Neuroscience Society Annual Meeting, Australia: British Medical Journal Publishing Group.
  • Wrigley, P., McCulloch, T. (2002). Complementary Medicine and Pain Medicine. The Australian Pain Society Newsletter.
  • Wrigley, P., Vaughan, C. (2002). Spinal cord processing of nociceptive inputs. University of Technology Sydney XIXth Scientific Research Meeting/University of Technology Sydney XIXth Scientific Research Meeting.

1998

  • Wrigley, P., Elliott, D., Blake, D. (1998). A Phase 2 Clinical Trial Comparing Ro 48-6791, a New Short-Acting Benzodiazepine, with Propofol for Induction of Anaesthesia. Anaesthesia and Intensive Care, 26(5), 509-514.

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