Dr Paul Wrigley

Senior Lecturer
Pain Medicine, Northern Clinical School
Pain Management & Research Institute

Telephone +61 2 9926 4958
Fax +61 2 9463 1050

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Research interests

Spinal cord injury pain particularly neuropathic pain.

Central neuroimaging (MRI and MRS) Sensory neurophysiology

Selected grants

2012

  • Neurophysiological assessment of residual thermonociceptive sensation following spinal cord injury - a pilot study; Wrigley P, Siddall P; Australian and New Zealand College of Anaesthetists/Research Project Grant.

2010

  • Regional changes in cerebral pefusion associated with persisent spinal cord injury neuropathic pain; Wrigley P, Henderson L, Siddall P; Australian and New Zealand College of Anaesthetists/Research Grants.

2008

  • Cortical and fibre tract changes in subjects with neuropathic pain following spinal cord injury; Wrigley P, Henderson L, Siddall P; Australian and New Zealand College of Anaesthetists/Research Grants.

2007

  • Development of an Australian spinal cord injury pain research data base; Wrigley P; Australian and New Zealand College of Anaesthetists/Research Grants.
  • Structural alterations of the human brain following complete spinal cord injury in people with and without neuropathic pain - a pilot study; Wrigley P; Pfizer Neuro Science Res Grants/Research Grant.

2004

  • Pfizer Neuroscience Grant; Wrigley P; Pfizer/Neuroscience Grant.

2002

  • Postgraduate Research Support Scheme Grant; Wrigley P; University of Sydney/Postgraduate Research Support Scheme Grant.
  • ANZCA Research Grant; Wrigley P, Vaughan C; ANZ Coll Anaesthetists (ANZCA)/Research Funding Scheme.

Selected publications

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Books

  • Wrigley, P. (2010). Cold Thermal Processing in the Spinal Cord: In Search of Therapeutic Targets for Cold Hyperesthesia. Saarbrucken: VDM Verlag Dr Muller.
  • Wrigley, P., Working Party, W. (2005). Acute Pain Management: Scientific Evidence. Melbourne: Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine.

Book Chapters

  • Siddall, P., Wrigley, P. (2010). Pain Following Spinal Cord Injury. In Scott Fishman, Jane Ballantyne, and James Rathmell (Eds.), Bonicas Management of Pain, (pp. 526-536). Baltimore: Lippincott Williams & Wilkins.
  • Wrigley, P., Siddall, P. (2010). The Clinical Evaluation of Pain. In Siu Lun Tsui et.al (Eds.), Pain Medicine: A Multidisciplinary Approach, (pp. 31-48). Hong Kong: Hong Kong University Press.
  • Siddall, P., Wrigley, P. (2008). Spinal cord injury. In Rice, A., Howard, R.F., Justins, D.M., Miaskowski, C.A. & Newton-John, T (Eds.), Clinical Pain Management: 4 Volume Set, (pp. 388-404). London: Hodder Arnold.
  • Siddall, P., Wrigley, P. (2008). Spinal cord injury. In Peter Wilson, Troels Jensen, Paul Watson and Jennifer A Haythornthwaite (Eds.), Clinical Pain Management: Chronic Pain, (pp. 388-404). London: Hodder Arnold.

Journals

  • Gustin, S., Wrigley, P., Youssef, A., McIndoe, L., Wilcox, S., Rae, C., Edden, R., Siddall, P., Henderson, L. (2014). Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury. Pain, 155(5), 1027-1036. [More Information]
  • Wrigley, P., Gustin, S., McIndoe, L., Chakiath, R., Henderson, L., Siddall, P. (2013). Longstanding neuropathic pain after spinal cord injury is refractory to transcranial direct current stimulation: A randomized controlled trial. Pain, 154(10), 2178-2184. [More Information]
  • Wang, D., Somogyi, A., Yee, B., Wong, K., Kaur, J., Wrigley, P., Grunstein, R. (2013). The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea. Respiratory Physiology and Neurobiology, 185(3), 526-532. [More Information]
  • Henderson, L., Gustin, S., Macey, P., Wrigley, P., Siddall, P. (2011). Functional Reorganization of the Brain in Humans Following Spinal Cord Injury: Evidence for Underlying Changes in Cortical Anatomy. The Journal of Neuroscience, 31(7), 2630-2637. [More Information]
  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2010). Brain Anatomy Changes Associated with Persistent Neuropathic Pain Following Spinal Cord Injury. Cerebral Cortex, 20(6), 1409-1419. [More Information]
  • Gustin, S., Wrigley, P., Henderson, L., Siddall, P. (2010). Brain circuitry underlying pain in response to imagined movement in people with spinal cord injury. Pain, 148(3), 438-445. [More Information]
  • Wrigley, P., Jeong, H., Vaughan, C. (2010). Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn. Molecular Pain, 6(1), 1-10. [More Information]
  • Wrigley, P., Gustin, S., Macey, P., Nash, P., Gandevia, S., Macefield, V., Siddall, P., Henderson, L. (2009). Anatomical Changes in Human Motor Cortex and Motor Pathways following Complete Thoracic Spinal Cord Injury. Cerebral Cortex, 19, 224-232. [More Information]
  • Wrigley, P., Press, S., Gustin, S., Macefield, V., Gandevia, S., Cousins, M., Middleton, J., Henderson, L., Siddall, P. (2009). Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. Pain, 141(1-2), 52-59. [More Information]
  • Wrigley, P., Jeong, H., Vaughan, C. (2009). Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurons. British Journal of Pharmacology, 157, 371-380. [More Information]
  • Wrigley, P., Cousins, M. (2008). Postherpetic neuralgia an update on management and prevention. Medicine Today, 9(4), 36-44.
  • Gustin, S., Wrigley, P., Gandevia, S., Middleton, J., Henderson, L., Siddall, P. (2007). Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury. Pain, 137(2), 237-244. [More Information]
  • Wrigley, P., Siddall, P. (2007). Pharmacological Interventions for Neuropathic Pain Following Spinal Cord Injury: An Update. Topics in Spinal Cord Injury Rehabilitation, 13(2), 58-71. [More Information]
  • Wrigley, P., Gustin, S., Nash, P., Macefield, V., Gandevia, S., Middleton, J., Siddall, P., Henderson, L. (2007). Structural changes associated with pain in spinal cord injured patients. European Journal of Pain, 11(1, Supplement 1), 97-98.
  • Smeal, W., Yezierski, R., Wrigley, P., Siddall, P., Jensen, M., Ehde, D. (2006). Spinal cord injury. The Journal of Pain, 7(12), 871-877.
  • Wrigley, P., Elliott, D., Blake, D. (1998). A Phase 2 Clinical Trial Comparing Ro 48-6791, a New Short-Acting Benzodiazepine, with Propofol for Induction of Anaesthesia. Anaesthesia and Intensive Care, 26(5), 509-514.

Conferences

  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2009). Brain Anatomy Changes Associated With Chronic Neuropathic Pain Following Spinal Cord Injury. ANZCA Annual Scientific Meeting 2009, New Zealand: Australian and New Zealand College of Anaesthetists.
  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2008). Changes in brain activity during mental allodynia. IASP 12th World Congress on Pain, United Kingdom: Elsevier.
  • Wrigley, P., Press, S., Gustin, S., Gandevia, S., Middleton, J., Cousins, M., Henderson, L., Siddall, P. (2008). Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. IASP 12th World Congress on Pain, United Kingdom: Elsevier.
  • Gustin, S., Wrigley, P., Nash, P., Macefield, V., Gandevia, S., Cousins, M., Henderson, L., Siddall, P. (2007). Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury. The Second International Congress on Neuropathic Pain (NeuPSIG), on line: Elsevier.
  • Wrigley, P., Vaughan, C. (2005). Spinal mechanisms of thermal nociceptive processing. International Association for the Study of Pain (IASP) 11th World Congress on Pain, 2005, Australia: International Association for the Study of Pain Press.
  • Wrigley, P., Vaughan, C. (2002). Cold afferent inputs activate a subpopulation of rat dorsal horn neurons in vitro. Australian Neuroscience Society Annual Meeting, Australia: British Medical Journal Publishing Group.
  • Wrigley, P., Vaughan, C. (2002). Spinal cord processing of nociceptive inputs. University of Technology Sydney XIXth Scientific Research Meeting/University of Technology Sydney XIXth Scientific Research Meeting.

Magazine / Newspaper Articles

  • Wrigley, P., McCulloch, T. (2002). Complementary Medicine and Pain Medicine. The Australian Pain Society Newsletter.

2014

  • Gustin, S., Wrigley, P., Youssef, A., McIndoe, L., Wilcox, S., Rae, C., Edden, R., Siddall, P., Henderson, L. (2014). Thalamic activity and biochemical changes in individuals with neuropathic pain after spinal cord injury. Pain, 155(5), 1027-1036. [More Information]

2013

  • Wrigley, P., Gustin, S., McIndoe, L., Chakiath, R., Henderson, L., Siddall, P. (2013). Longstanding neuropathic pain after spinal cord injury is refractory to transcranial direct current stimulation: A randomized controlled trial. Pain, 154(10), 2178-2184. [More Information]
  • Wang, D., Somogyi, A., Yee, B., Wong, K., Kaur, J., Wrigley, P., Grunstein, R. (2013). The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea. Respiratory Physiology and Neurobiology, 185(3), 526-532. [More Information]

2011

  • Henderson, L., Gustin, S., Macey, P., Wrigley, P., Siddall, P. (2011). Functional Reorganization of the Brain in Humans Following Spinal Cord Injury: Evidence for Underlying Changes in Cortical Anatomy. The Journal of Neuroscience, 31(7), 2630-2637. [More Information]

2010

  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2010). Brain Anatomy Changes Associated with Persistent Neuropathic Pain Following Spinal Cord Injury. Cerebral Cortex, 20(6), 1409-1419. [More Information]
  • Gustin, S., Wrigley, P., Henderson, L., Siddall, P. (2010). Brain circuitry underlying pain in response to imagined movement in people with spinal cord injury. Pain, 148(3), 438-445. [More Information]
  • Wrigley, P. (2010). Cold Thermal Processing in the Spinal Cord: In Search of Therapeutic Targets for Cold Hyperesthesia. Saarbrucken: VDM Verlag Dr Muller.
  • Wrigley, P., Jeong, H., Vaughan, C. (2010). Dissociation of μ- and δ-opioid inhibition of glutamatergic synaptic transmission in superficial dorsal horn. Molecular Pain, 6(1), 1-10. [More Information]
  • Siddall, P., Wrigley, P. (2010). Pain Following Spinal Cord Injury. In Scott Fishman, Jane Ballantyne, and James Rathmell (Eds.), Bonicas Management of Pain, (pp. 526-536). Baltimore: Lippincott Williams & Wilkins.
  • Wrigley, P., Siddall, P. (2010). The Clinical Evaluation of Pain. In Siu Lun Tsui et.al (Eds.), Pain Medicine: A Multidisciplinary Approach, (pp. 31-48). Hong Kong: Hong Kong University Press.

2009

  • Wrigley, P., Gustin, S., Macey, P., Nash, P., Gandevia, S., Macefield, V., Siddall, P., Henderson, L. (2009). Anatomical Changes in Human Motor Cortex and Motor Pathways following Complete Thoracic Spinal Cord Injury. Cerebral Cortex, 19, 224-232. [More Information]
  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2009). Brain Anatomy Changes Associated With Chronic Neuropathic Pain Following Spinal Cord Injury. ANZCA Annual Scientific Meeting 2009, New Zealand: Australian and New Zealand College of Anaesthetists.
  • Wrigley, P., Press, S., Gustin, S., Macefield, V., Gandevia, S., Cousins, M., Middleton, J., Henderson, L., Siddall, P. (2009). Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. Pain, 141(1-2), 52-59. [More Information]
  • Wrigley, P., Jeong, H., Vaughan, C. (2009). Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurons. British Journal of Pharmacology, 157, 371-380. [More Information]

2008

  • Gustin, S., Wrigley, P., Siddall, P., Henderson, L. (2008). Changes in brain activity during mental allodynia. IASP 12th World Congress on Pain, United Kingdom: Elsevier.
  • Wrigley, P., Press, S., Gustin, S., Gandevia, S., Middleton, J., Cousins, M., Henderson, L., Siddall, P. (2008). Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. IASP 12th World Congress on Pain, United Kingdom: Elsevier.
  • Wrigley, P., Cousins, M. (2008). Postherpetic neuralgia an update on management and prevention. Medicine Today, 9(4), 36-44.
  • Siddall, P., Wrigley, P. (2008). Spinal cord injury. In Rice, A., Howard, R.F., Justins, D.M., Miaskowski, C.A. & Newton-John, T (Eds.), Clinical Pain Management: 4 Volume Set, (pp. 388-404). London: Hodder Arnold.
  • Siddall, P., Wrigley, P. (2008). Spinal cord injury. In Peter Wilson, Troels Jensen, Paul Watson and Jennifer A Haythornthwaite (Eds.), Clinical Pain Management: Chronic Pain, (pp. 388-404). London: Hodder Arnold.

2007

  • Gustin, S., Wrigley, P., Gandevia, S., Middleton, J., Henderson, L., Siddall, P. (2007). Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury. Pain, 137(2), 237-244. [More Information]
  • Gustin, S., Wrigley, P., Nash, P., Macefield, V., Gandevia, S., Cousins, M., Henderson, L., Siddall, P. (2007). Movement imagery increases pain in people with neuropathic pain following complete thoracic spinal cord injury. The Second International Congress on Neuropathic Pain (NeuPSIG), on line: Elsevier.
  • Wrigley, P., Siddall, P. (2007). Pharmacological Interventions for Neuropathic Pain Following Spinal Cord Injury: An Update. Topics in Spinal Cord Injury Rehabilitation, 13(2), 58-71. [More Information]
  • Wrigley, P., Gustin, S., Nash, P., Macefield, V., Gandevia, S., Middleton, J., Siddall, P., Henderson, L. (2007). Structural changes associated with pain in spinal cord injured patients. European Journal of Pain, 11(1, Supplement 1), 97-98.

2006

  • Smeal, W., Yezierski, R., Wrigley, P., Siddall, P., Jensen, M., Ehde, D. (2006). Spinal cord injury. The Journal of Pain, 7(12), 871-877.

2005

  • Wrigley, P., Working Party, W. (2005). Acute Pain Management: Scientific Evidence. Melbourne: Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine.
  • Wrigley, P., Vaughan, C. (2005). Spinal mechanisms of thermal nociceptive processing. International Association for the Study of Pain (IASP) 11th World Congress on Pain, 2005, Australia: International Association for the Study of Pain Press.

2002

  • Wrigley, P., Vaughan, C. (2002). Cold afferent inputs activate a subpopulation of rat dorsal horn neurons in vitro. Australian Neuroscience Society Annual Meeting, Australia: British Medical Journal Publishing Group.
  • Wrigley, P., McCulloch, T. (2002). Complementary Medicine and Pain Medicine. The Australian Pain Society Newsletter.
  • Wrigley, P., Vaughan, C. (2002). Spinal cord processing of nociceptive inputs. University of Technology Sydney XIXth Scientific Research Meeting/University of Technology Sydney XIXth Scientific Research Meeting.

1998

  • Wrigley, P., Elliott, D., Blake, D. (1998). A Phase 2 Clinical Trial Comparing Ro 48-6791, a New Short-Acting Benzodiazepine, with Propofol for Induction of Anaesthesia. Anaesthesia and Intensive Care, 26(5), 509-514.

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