Associate Professor Paul Young

Principal Research Fellow
Pharmacology, School of Medical Sciences
Woolcock Institute of Medical Research

Telephone +61 2 9114 0350

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Biographical details

Paul M Young is Head of Respiratory Technology at the Woolcock Institute of Medical Research. His Team focusses on developing advanced drug delivery systems for treating a wide range of respiratory disorders ranging from asthma to Tuberculosis. For more information regarding our Team visit our website (link at top of page).

Research interests

A general interest into all areas of Pharmaceutical Technology, including solid dosage forms, inhalation, nasal delivery, colloidal science, controlled release and surface/interfacial science. Specific areas of current research are highlighted below:

Respiratory Drug Delivery

Dry powder inhalation (DPI)

Pressurised metered dose inhalers (pMDI)

Controlled release respiratory therapy

Surface and Interface science

Solid dosage forms

Selected grants

2014

  • One for all and all for one: Engineering a drug delivery platform for DNA vaccines to the lung; Traini D, Young P, Windhab N; Australian Research Council (ARC)/Linkage Projects (LP).
  • CSI-Sydney: New technologies to treat chronic sinus infection; Young P, Traini D, King G, Bailey D, Whitchurch C, Rohanizadeh R; National Health and Medical Research Council (NHMRC)/Development Grants.
  • Using Electric Cell-substrate Impedance to explore the regulation of angiogenesis in asthma; Burgess J, Oliver B, Young P; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2013

  • A tight squeeze: Engineering anti-fibrotic depot aerosols that circumvent the epithelia; Young P, Traini D, Oliver B, Jarolimek W; Australian Research Council (ARC)/Linkage Projects (LP).
  • WITEC Alpha 300R High Throughput Microscope - Confocal Raman Microscope; Traini D, Young P, Murray M, Dehghani F, Chan H, Oliver B, Holst J; DVC Research/Equipment Grant.
  • From ECR to Star! Establishment of an early career researcher network and workshop series that enhances collaboration and funding in the area of respiratory science; Traini D, Young P, Gaisford S; IPDF - Other/IPDF Contribution.

2012

  • An attack from all angles! Multiphase particle systems that target respiratory infection; Young P; Australian Research Council (ARC)/Future Fellowships (FT).
  • Ultra-low dose dry powder inhaler technology for the treatment of respiratory diseases; Young P, Traini D, Fletcher D; Australian Research Council (ARC)/Linkage Projects (LP).
  • Treating tuberculosis: targeted delivery of multidrug nano-suspensions.; Traini D, Young P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Multi-drug dry powder inhalation systems for the effective treatment of chronic obstructive pulmonary disease; Young P, Stewart P, Traini D, Stewart P, Honnery D; Australian Research Council (ARC)/Discovery Projects (DP).

2011

  • Accessing the third-dimension in scanning electron microscopy for rapid, high-resolution tomography of large samples materials; Liu Z, Perrier S, Mai Y, Young P, Bandyopadhyay S, Braet F, Burford R, Housley G, Thordarson P; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2010

  • Engineering of composite particles to enhance performance in respiratory drug delivery; Traini D, Saunders M, Young P, Chan H; Australian Research Council (ARC)/Linkage Projects (LP).
  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The effect of electrostatic charge on the plume of pressurised metered dose inhalers; Traini D, Lewis D, Young P, Chan H; Australian Research Council (ARC)/Linkage Projects (LP).
  • Combination and controlled release inhalation formulating; Young P; DVC Research/Bridging Support Grant.
  • Surface Energy Analyser (SEA); Traini D, Young P, Chan H, Rohanizadeh R, Bilek M, Langrish T, Gomes V; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Bruker APEX II CCD Detector Fourth Generation APEX II ultra-low noise CCD X-ray detector with 16 megapixel chip; Hibbs D, Roufogalis B, Murray M, Hambley T, Hanrahan J, Church W, Collins M, Johnston G, Young P, Traini D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Rapid inhaler prototyping and development; Young P; DVC Research/Bridging Support Grant.
  • A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation; Munroe P, Jones A, Zhou H, Cairney J, Einav I, Swain M, Murphy C, Seibel M, Ringer S, Li Q, Darendeliler M, Wang X, Zhang Y, Hand S, Archer M, Ramzan I, Young P, Traini D, Richardson D, Masters A, Milthorpe B; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2008

  • Nanoscale Thermal Imaging (SThM); Young P, Traini D, Yang W, Braet F, Chan H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Engineering of co-crystal drug molecules for pharmaceutical aerosols; Young P, Traini D; Australian Research Council (ARC)/Discovery Projects (DP).

2007

  • Development of an electrostatic apparatus for the evaluation of the charge distributions in aerosols for respiratory delivery; Young P; University of Sydney/Research & Development.
  • Mannitol Powders for Assessment of Asthma in Children; Chan H, Young P, Crapper J, Traini D; Australian Research Council (ARC)/Linkage Projects (LP).
  • State of the art high resolution thermal analysis suite for the life and material sciences; Stewart P, Young P, Traini D, Chan H, Murray M, Dehghani F, Hibbs D, Larson I, Warr G, Weiss A; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Engineering a delivery device and development of a novel formulation for chronic obstructive pulmonary disease and cystic fibrosis; Fletcher D, Crapper J, Young P, Chan H, Traini D; Australian Research Council (ARC)/Linkage Projects (LP).
  • Precision Titration/ Solution Calorimeter accessory for the Tam III Iosthermal calorimeter Calorimet; Chan H, Murray M, Hibbs D, Young P, Traini D, Weiss A, Stewart P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2006

  • Formulation Of Anti-Inflammatory Aerosols For The Treatment Of Pathogenic Lung Infection; Chan H, Traini D, Young P; Pharmacy Research Trust of NSW/Research Grants Program.
  • Engineered Carrier Material to Improve Drug Deposition in the Respiratory Tract; Young P; University of Sydney/Early Career Researcher.
  • Characterising particulate laden flow in the lung airways: from drug delivery to primary anthropogen; Young P, Stewart P, Chan H, Soria J, Honnery D, Thompson B, Larson I; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

Selected publications

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Edited Books

  • Dalby, R., Byron, P., Peart, J., Suman, J., Young, P. (2009). RDD Europe 2009: Respiratory Drug Delivery. United States: Davis Healthcare International Publishing.

Book Chapters

  • Traini, D., Young, P. (2013). Formulation of inhalation medicines. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 31-45). Chichester, UK: John Wiley & Sons.
  • Traini, D., Young, P. (2013). Inhalation and nasal products. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 15-30). Chichester, UK: John Wiley & Sons.
  • Young, P., Traini, D., Edge, S. (2008). Advances in Pulmonary Therapy. In Williams, Taft and McConville (Eds.), Advanced Drug Formulation Design to Optimize Therapeutic Outcome, (pp. 1-51). USA: Informa Healthcare.

Journals

  • Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
  • Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
  • Ong, H., Traini, D., Ballerin, G., Morgan, L., Buddle, L., Scalia, S., Young, P. (2014). Combined inhaled salbutamol and mannitol therapy for mucus hyper-secretion in pulmonary diseases. The AAPS Journal, 16(2), 269-280. [More Information]
  • Salama, R., Young, P., Traini, D. (2014). Concurrent oral and inhalation drug delivery using a dual formulation system: the use of oral theophylline carrier with combined inhalable budesonide and terbutaline. Drug Delivery and Translational Research, 4(3), 256-267. [More Information]
  • Ong, H., Benaouda, F., Traini, D., Cipolla, D., Gonda, I., Bebawy, M., Forbes, B., Young, P. (2014). In vitro and ex vivo methods predict the enhanced lung residence time of liposomal ciprofloxacin formulations for nebulisation. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 83-89. [More Information]
  • Haghi, M., Traini, D., Young, P. (2014). In Vitro Cell Integrated Impactor Deposition Methodology for the Study of Aerodynamically Relevant Size Fractions from Commercial Pressurised Metered Dose Inhalers. Pharmaceutical Research, 31(7), 1779-1787. [More Information]
  • Niaz, M., Traini, D., Young, P., Ghadiri, M., Rohanizadeh, R. (2014). Investigation into physical-chemical variables affecting the manufacture and dissolution of wet-milled clarithromycin nanoparticles. Pharmaceutical Development and Technology, 19(8), 911-921. [More Information]
  • Ooi, J., Gaisford, S., Boyd, B., Young, P., Traini, D. (2014). Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems. International Journal of Pharmaceutics, 461(1-2), 301-309. [More Information]
  • Ooi, J., Gaisford, S., Boyd, B., Young, P., Traini, D. (2014). Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems. International Journal of Pharmaceutics, 461(1-2), 301-309. [More Information]
  • Young, P., Crapper, J., Gary, P., Sharma, K., Chan, H., Traini, D. (2014). Overcoming Dose Limitations Using the Orbital(®) Multi-Breath Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2), 138-147. [More Information]
  • Lee, W., Loo, J., Young, P., Traini, D., Mason, R., Rohanizadeh, R. (2014). Recent advances in curcumin nanoformulation for cancer therapy. Expert Opinion on Drug Delivery, 11(8), 1183-1201. [More Information]
  • DAVIS, S., Durvasula, S., Merhi, D., Young, P., Traini, D., Bosnic-Anticevich, S. (2014). Respiratory medication use in an Australian developmental disability clinic population: messages for health care professionals. Australian Journal of Primary Health, 20(30), 278-284. [More Information]
  • Loo, J., Young, P., Cavaliere, R., Whitchurch, C., Lee, W., Rohanizadeh, R. (2014). Silver nanoparticles enhance Pseudomonas aeruginosa PAO1 biofilm detachment. Drug Development and Industrial Pharmacy, 40(6), 719-729. [More Information]
  • Saadat, A., Zhu, B., Haghi, M., King, G., Colombo, G., Young, P., Traini, D. (2014). The formulation, chemical and physical characterisation of clarithromycin-based macrolide solution pressurised metered dose inhaler. Journal of Pharmacy and Pharmacology, 66(5), 639-645. [More Information]
  • Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2014). The Influence of Actuator Materials and Nozzle Designs on Electrostatic Charge of Pressurised Metered Dose Inhaler (pMDI) Formulations. Pharmaceutical Research, 31(5), 1325-1337. [More Information]
  • Zhu, B., Traini, D., Lewis, D., Young, P. (2014). The solid-state and morphological characteristics of particles generated from solution-based metered dose inhalers: Influence of ethanol concentration and intrinsic drug properties. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 443, 345-355. [More Information]
  • Lewis, D., Young, P., Buttini, F., Church, T., Colombo, P., Forbes, B., Haghi, M., Johnson, R., O'Shea, H., Salama, R., Traini, D. (2014). Towards the bioequivalence of pressurised metered dose inhalers 1: Design and characterisation of aerodynamically equivalent beclomethasone dipropionate inhalers with and without glycerol as a non-volatile excipient. European Journal of Pharmaceutics and Biopharmaceutics, 86, 31-37. [More Information]
  • Haghi, M., Bebawy, M., Colombo, P., Forbes, B., Lewis, D., Salama, R., Traini, D., Young, P. (2014). Towards the bioequivalence of pressurised metered dose inhalers 2. Aerodynamically equivalent particles (with and without glycerol) exhibit different biopharmaceutical profiles in vitro. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 38-45. [More Information]
  • Chan, J., Chan, H., Prestidge, C., Denman, J., Young, P., Traini, D. (2013). A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 285-292. [More Information]
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2013). Ciprofloxacin Is Actively Transported across Bronchial Lung Epithelial Cells Using a Calu-3 Air Interface Cell Model. Antimicrobial Agents and Chemotherapy, 57(6), 2535-2540. [More Information]
  • Scalia, S., Traini, D., Young, P., Di Sabatino, M., Passerini, N., Albertini, B. (2013). Comparison of spray congealing and melt emulsification methods for the incorporation of the water-soluble salbutamol sulphate in lipid microparticles. Pharmaceutical Development and Technology, 18(1), 266-273. [More Information]
  • Martínez, L., Betz, G., Villalobos, R., Melgoza, L., Young, P. (2013). Correlation between compactibility values and excipient cluster size using an in silico approach. Drug Development and Industrial Pharmacy, 39(2), 374-381. [More Information]
  • Haghi, M., Traini, D., Postma, D., Bebawy, M., Young, P. (2013). Fluticasone uptake across Calu-3 cells is mediated by salmeterol when deposited as a combination powder inhaler. Respirology, 18(8), 1197-1201. [More Information]
  • Scalia, S., Trotta, V., Traini, D., Young, P., Sticozzi, C., Cervellati, F., Valacchi, G. (2013). Incorporation of quercetin in respirable lipid microparticles: Effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells. Colloids And Surfaces B: Biointerfaces, 112, 322-329. [More Information]
  • Marin, L., Traini, D., Bebawy, M., Colombo, P., Buttini, F., Haghi, M., Ong, H., Young, P. (2013). Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: Implications in the treatment of chronic obstructive airway pathologies. European Journal of Pharmaceutics and Biopharmaceutics, 84(3), 566-572. [More Information]
  • Ong, H., Traini, D., Young, P. (2013). Pharmaceutical applications of the Calu-3 lung epithelia cell line. Expert Opinion on Drug Delivery, 10(9), 1287-1302. [More Information]
  • Scalia, S., Haghi, M., Losi, V., Trotta, V., Young, P., Traini, D. (2013). Quercetin solid lipid microparticles: A flavonoid for inhalation lung delivery. European Journal of Pharmaceutical Sciences, 49(2), 278-285. [More Information]
  • Mamlouk, M., Young, P., Bebawy, M., Haghi, M., Mamlouk, S., Mulay, V., Traini, D. (2013). Salbutamol Sulfate Absorption Across Calu-3 Bronchial Epithelia Cell Monolayer is Inhibited in the Presence of Common Anionic NSAIDs. Journal of Asthma, 50(4), 334-341. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug Development and Industrial Pharmacy, 39(11), 1625-1637. [More Information]
  • Ong, H., Traini, D., Salama, R., Anderson, S., Daviskas, E., Young, P. (2013). The Effects of Mannitol on the Transport of Ciprofloxacin across Respiratory Epithelia. Molecular Pharmaceutics, 10(8), 2915-2924. [More Information]
  • Adi, H., Young, P., Traini, D. (2012). Co-deposition of a triple therapy drug formulation for the treatment of chronic obstructive pulmonary disease using solution-based pressurised metered dose inhalers. Journal of Pharmacy and Pharmacology, 64(9), 1245-1253. [More Information]
  • Chan, J., Traini, D., Chan, H., Young, P., Kwok, P. (2012). Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(5), 297-305. [More Information]
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2012). Deposition, Diffusion and Transport Mechanism of Dry Powder Microparticulate Salbutamol, at the Respiratory Epithelia. Molecular Pharmaceutics, 9(6), 1717-1726. [More Information]
  • Ong, H., Traini, D., Cipolla, D., Gonda, I., Bebawy, M., Agus, H., Young, P. (2012). Liposomal Nanoparticles Control the Uptake of Ciprofloxacin Across Respiratory Epithelia. Pharmaceutical Research, 29(12), 3335-3346. [More Information]
  • Upadhyay, D., Scalia, S., Vogel, R., Wheate, N., Salama, R., Young, P., Traini, D., Chrzanowski, W. (2012). Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery. Pharmaceutical Research, 29(9), 2456-2467. [More Information]
  • Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D. (2012). Micronized drug powders in binary mixtures and the effect of physical properties on aerosolization from combination drug dry powder inhalers. Drug Development and Industrial Pharmacy, 38(12), 1504-1511. [More Information]
  • Haghi, M., Salama, R., Traini, D., Bebawy, M., Young, P. (2012). Modification of Disodium Cromoglycate Passage Across Lung Epithelium In Vitro Via Incorporation into Polymeric Microparticles. The AAPS Journal, 14(1), 79-86. [More Information]
  • Villalobos, R., Viquez, H., Hernandez, B., Ganem, A., Melgoza, L., Young, P. (2012). Parameters affecting drug release from inert matrices. 1: Monte Carlo simulation. Pharmaceutical Development and Technology, 17(3), 344-352. [More Information]
  • Traini, D., Scalia, S., Adi, H., Marangoni, E., Young, P. (2012). Polymer coating of carrier excipients modify aerosol performance of adhered drugs used in dry powder inhalation therapy. International Journal of Pharmaceutics, 438(1-2), 150-159. [More Information]
  • Traini, D., Adi, H., Valet, O., Young, P. (2012). Preparation and Evaluation of Single and Co-Engineered Combination Inhalation Carrier Formulations for the Treatment of Asthma. Journal of Pharmaceutical Sciences, 101(11), 4267-4276. [More Information]
  • Scalia, S., Salama, R., Young, P., Traini, D. (2012). Preparation and in vitro evaluation of salbutamol-loaded lipid microparticles for sustained release pulmonary therapy. Journal of Microencapsulation, 29(3), 225-233. [More Information]
  • Loo, J., Young, P., Lee, W., Cavaliere, R., Whitchurch, C., Rohanizadeh, R. (2012). Superhydrophobic, nanotextured polyvinyl chloride films for delaying Pseudomonas aeruginosa attachment to intubation tubes and medical plastics. Acta Biomaterialia, 8(5), 1881-1890. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Young, P. (2012). The use of computational approaches in inhaler development. Advanced Drug Delivery Reviews, 64(4), 312-322. [More Information]
  • Jones, M., Young, P., Traini, D. (2012). The use of inverse gas chromatography for the study of lactose and pharmaceutical materials used in dry powder inhalers. Advanced Drug Delivery Reviews, 64(3), 285-293. [More Information]
  • Rogueda, P., Lallement, A., Traini, D., Iliev, I., Young, P. (2012). Twenty years of HFA pMDI patents: facts and perspectives. Journal of Pharmacy and Pharmacology, 64(9), 1209-1216. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). A Review of Electrostatic Measurement Techniques for Aerosol Drug Delivery to the Lung: Implications in Aerosol Particle Deposition. Journal of Adhesion Science and Technology, 25(4-5), 385-405. [More Information]
  • Salama, R., Young, P., Rogueda, P., Lallement, A., Iliev, I., Traini, D. (2011). Advances in drug delivery: is triple therapy the future for the treatment of chronic obstructive pulmonary disease? Expert Opinion on Pharmacotherapy, 12(12), 1913-1932. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). Aerosol tribocharging and its relation to the deposition of Oxis Turbuhaler in the electrical next generation impactor. Journal of Pharmaceutical Sciences, 100(12), 5270-5280. [More Information]
  • Marin, L., Colombo, P., Bebawy, M., Young, P., Traini, D. (2011). Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management. Expert Opinion on Drug Delivery, 8(9), 1205-1220. [More Information]
  • Ooi, J., Traini, D., Hoe, S., Wong, W., Young, P. (2011). Does carrier size matter? A fundamental study of drug aerosolisation from carrier based dry powder inhalation systems. International Journal of Pharmaceutics, 413(1-2 (Feb)), 1-9. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). Dynamic electrostatic charge of lactose-salbutamol sulphate powder blends dispersed from a Cyclohaler. Drug Development and Industrial Pharmacy, 37(11), 1365-1375. [More Information]
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2011). Epithelial Profiling of Antibiotic Controlled Release Respiratory Formulations. Pharmaceutical Research, 28(9), 2327-2338. [More Information]
  • Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
  • Abdel-Halim, H., Traini, D., Hibbs, D., Gaisford, S., Young, P. (2011). Modelling of molecular phase transitions in pharmaceutical inhalation compounds: an in silico approach. European Journal of Pharmaceutics and Biopharmaceutics, 78(1), 83-89. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-Up in Dry Powder Inhalers: Evaluation and Modelling of Impaction Effects for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(7), 2744-2754. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-up in Dry Powder Inhalers: Evaluation and Modelling of the Influence of Grid Structures for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(11), 4710-4721. [More Information]
  • Lee, Y., Wu, J., Yang, M., Young, P., Van den Berg, F., Rantanen, J. (2011). Particle size dependence of polymorphism in spray-dried mannitol. European Journal of Pharmaceutical Sciences, 44(1-2), 41-48. [More Information]
  • Rogueda, P., Price, R., Smith, T., Young, P., Traini, D. (2011). Particle synergy and aerosol performance in non-aqueous liquid of two combinations metered dose inhalation formulations: an AFM and Raman investigation. Journal of Colloid and Interface Science, 361(2), 649-655. [More Information]
  • Young, P., Wood, O., Ooi, J., Traini, D. (2011). The influence of drug loading on formulation structure and aerosol performance in carrier based dry powder inhalers. International Journal of Pharmaceutics, 416(1), 129-135. [More Information]
  • Strusi, O., Barata, P., Traini, D., Young, P., Mercuri, S., Colombo, G., Sonvico, F., Bettini, R., Colombo, P. (2010). Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products. Journal of Controlled Release, 146(1), 54-60. [More Information]
  • Adi, H., Young, P., Chan, H., Agus, H., Traini, D. (2010). Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European Journal of Pharmaceutical Sciences, 40, 239-247. [More Information]
  • Adi, H., Young, P., Chan, H., Salama, R., Traini, D. (2010). Controlled release antibiotics for dry powder lung delivery. Drug Development and Industrial Pharmacy, 36(1), 119-126. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2010). Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems. Pharmaceutical Research, 27(7), 1367-1376. [More Information]
  • Wong, W., Crapper, J., Chan, H., Traini, D., Young, P. (2010). Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of Pharmaceutical and Biomedical Analysis, 51(4), 853-857. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2010). The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems. Pharmaceutical Research, 27(7), 1325-1336. [More Information]
  • Haghi, M., Young, P., Traini, D., Jaiswal, R., Gong, J., Bebawy, M. (2010). Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model. Drug Development and Industrial Pharmacy, 36(10), 1207-1214. [More Information]
  • Das, S., Larson, I., Young, P., Stewart, P. (2010). Understanding lactose behaviour during storage by monitoring surface energy change using inverse gas chromatography. Dairy Science and Technology, 90(2-3), 271-285. [More Information]
  • Das, S., Larson, I., Young, P., Stewart, P. (2009). Agglomerate properties and dispersibility changes of salmeterol xinafoate from powders for inhalation after storage at high relative humidity. European Journal of Pharmaceutical Sciences, 37(3-4), 442-450. [More Information]
  • Traini, D., Young, P. (2009). Delivery of antibiotics to the respiratory tract: an update. Expert Opinion on Drug Delivery, 6(9), 897-905. [More Information]
  • Salama, R., Ladd, L., Chan, H., Traini, D., Young, P. (2009). Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. The AAPS Journal, 11(3), 465-468. [More Information]
  • Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
  • Das, S., Larson, I., Young, P., Stewart, P. (2009). Influence of Storage Relative Humidity on the Dispersion of Salmeterol Xinafoate Powders for Inhalation. Journal of Pharmaceutical Sciences, 98(3), 1015-1027. [More Information]
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Introduction of the Electrical Next Generation Impactor (eNGI) and Investigation of its Capabilities for the Study of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 26(2), 431-437. [More Information]
  • Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences, 38, 88-94. [More Information]
  • Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
  • Parlati, C., Colombo, P., Buttini, F., Young, P., Adi, H., Ammit, A., Traini, D. (2009). Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency. Pharmaceutical Research, 26(5), 1084-1092. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2009). Recent Advances in Controlled Release Pulmonary Therapy. Current Drug Delivery, 6(4), 404-414. [More Information]
  • Mezzena, M., Scalia, S., Young, P., Traini, D. (2009). Solid Lipid Budesonide Microparticles for Controlled Release Inhalation Therapy. The AAPS Journal, 11(4), 771-778. [More Information]
  • Das, S., Larson, I., Young, P., Stewart, P. (2009). Surface energy changes and their relationship with the dispersibility of salmeterol xinafoate powders for inhalation after storage at high RH. European Journal of Pharmaceutical Sciences, 38(4), 347-354. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers. Pharmaceutical Research, 26(12), 2639-2646. [More Information]
  • Young, P., Adi, H., Patel, T., Law, K., Rogueda, P., Traini, D. (2009). The influence of micronised particulates on the aerosolisation properties of pressurised metered dose inhalers. Journal of Aerosol Science, 40, 324-337. [More Information]
  • Young, P., Price, R. (2008). Comparative measurement of pressurised metered dose inhaler (pMDI) stem displacement. Drug Development and Industrial Pharmacy, 34(1), 90-94. [More Information]
  • Young, P., Roberts, D., Chiou, H., Rae, W., Chan, H., Traini, D. (2008). Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science, 39, 82-93. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2008). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, 97(8), 3356-3366. [More Information]
  • Hoe, S., Young, P., Rogueda, P., Traini, D. (2008). Determination of reference ultrasound parameters for model and hydrofluoroalkane propellants using high-resolution ultrasonic spectroscopy. AAPS PharmSciTech, 9(2), 605-611. [More Information]
  • Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information]
  • Young, P., Nguyen, K., Jones, A., Traini, D. (2008). Microstructural Analysis of Porous Composite Materials: Dynamic Imaging of Drug Dissolution and Diffusion Through Porous Matrices. The AAPS Journal, DOI: 10.1208/s12248-008-9063-2(Print version 2008 Vol. 10 pp. 560-564), 1-5. [More Information]
  • Salama, R., Hoe, S., Chan, H., Traini, D., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 486-495. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 145-152. [More Information]
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2008). Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences, 97(8), 3140-3152.
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D., Yang, R., Yu, A. (2008). Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir, 24(19), 11307-11312. [More Information]
  • Steele, D., Moreton, R., Staniforth, J., Young, P., Tobyn, M., Edge, S. (2008). Surface Energy of Microcrystalline Cellulose Determined by Capillary Intrusion and Inverse Gas Chromatography. The AAPS Journal, 10(3), 494-503. [More Information]
  • Traini, D., Young, P., Thielmann, F., Acharya, M. (2008). The influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulations. Drug Development and Industrial Pharmacy, 34(9), 992-1001. [More Information]
  • Jones, M., Young, P., Traini, D., Shur, J., Edge, S., Price, R. (2008). The use of atomic force microscopy to study the conditioning of micronised budesonide. International Journal of Pharmaceutics, 357(1-2), 314-317. [More Information]
  • Traini, D., Loreti, G., Jones, A., Young, P. (2008). X-Ray Computed Microtomography for the Study of Modified Release Systems. Microscopy and Analysis, 22(1), 13-15.
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2007). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, online(DOI 10.1002/jps.21239), 1-11. [More Information]
  • Chan, H., Young, P., Traini, D., Coates, M. (2007). Dry powder inhalers: challenges and goals for next generation therapies. Pharmaceutical Technology Europe, 19(4), 19-24.
  • Young, P., Edge, S., Staniforth, J., Steele, D., Traini, D., Price, R. (2007). Effect of Moisture on the Compressibility and Compactibility of Sodium Starch Glycolate. Pharmaceutical Development and Technology, 12(2), 217-222.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2007). In Vitro Investigation of Drug Particulates Interactions and Aerosol Performance of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 24(1), 125-135. [More Information]
  • Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
  • Young, P., Edge, S., Staniforth, J., Steele, D., Price, R. (2007). Interaction of Moisture with Sodium Starch Glycolate. Pharmaceutical Development and Technology, 12(2), 211-216. [More Information]
  • Young, P., Traini, D., Coates, M., Chan, H. (2007). Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, 394(2), 315-319.
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2007). Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences, 97(8), 3140-3152. [More Information]
  • Adi, H., Traini, D., Chan, H., Young, P. (2007). The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Sciences, Published online DOI 10.1002/jps.21195(Print version 2008 VOL. 97, NO. 7), 2780-2788. [More Information]
  • Young, P., Chan, H., Chiou, H., Edge, S., Tee, H., Traini, D. (2007). The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of Pharmaceutical Sciences, 96(5), 1331-1341. [More Information]
  • Young, P., Chiou, H., Tee, H., Traini, D., Chan, H., Thielmann, F., Burnett, D. (2007). The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, 33(1), 91-97. [More Information]
  • Traini, D., Young, P., Price, R., Rogueda, P. (2006). A novel apparatus for the determination of solubility in pressurized metered dose inhalers. Drug Development and Industrial Pharmacy, 32(10), 1159-1163. [More Information]
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2006). Agglomerate Strength and Dispersion of Salmeterol Xinafoate from Powder Mixtures for Inhalation. Pharmaceutical Research, 23(11), 2556-2565. [More Information]
  • Kaerger, J., Price, R., Young, P., Edge, S., Tobyn, M. (2006). Carriers for DPIs: Formulation and regulatory challenges. Pharmaceutical Technology Europe, 18(10), 25-30.
  • Traini, D., Young, P., Jones, M., Edge, S., Price, R. (2006). Comparative study of erythritol and lactose monohydrate as carriers for inhalation: atomic force microscopy and in vitro correlation. European Journal of Pharmaceutical Sciences, 27(2-3), 243-251. [More Information]
  • El-Sabawi, D., Edge, S., Price, R., Young, P. (2006). Continued investigation into the influence of loaded dose on the performance of dry powder inhalers: Surface smoothing effects. Drug Development and Industrial Pharmacy, 32(10), 1135-1138. [More Information]
  • Burnett, D., Thielmann, F., Young, P. (2006). Determination of the amorphous content in excipients and drugs. Journal of Pharmacy and Pharmacology, 58(supplement 1), A21 (abstract 53)-A21.
  • Thielmann, F., Young, P. (2006). Impact of lactose polymorphism on salbutamol sulphate-lactose interactions in DPI formulations. Journal of Pharmacy and Pharmacology, 58(supplement 1), A20 (abstract 52)-A21.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2006). Investigation into the influence of polymeric stabilizing excipients on inter-particulate forces in pressurised metered dose inhalers. International Journal of Pharmaceutics, 320(1-2), 58-63. [More Information]
  • El-Sabawi, D., Price, R., Edge, S., Young, P. (2006). Novel temperature controlled surface dissolution of excipient particles for carrier based dry powder inhaler formulations. Drug Development and Industrial Pharmacy, 32(2), 243-251. [More Information]
  • Traini, D., Young, P., Rogueda, P., Price, R. (2006). The use of AFM and surface energy measurements to investigate drug-canister material interactions in a model pressurized metered dose inhaler formulation. Aerosol Science and Technology, 40(4), 227-236.
  • Young, P., Tobyn, M., Price, R., Buttrum, M., DEY, F. (2006). The Use of Colloid Probe Microscopy to Predict Aerosolization Performance in Dry Powder Inhalers: AFM and In Vitro Correlation. Journal of Pharmaceutical Sciences, 95(8), 1800-1809. [More Information]
  • Young, P., Edge, S., Staniforth, J., Steele, D., Price, R. (2005). Dynamic vapor sorption properties of sodium starch glycolate disintegrants. Pharmaceutical Development and Technology, 10(2), 249-259.
  • Price, R., Young, P. (2005). On the physical transformations of processed pharmaceutical solids. Micron, 36(6), 519-524.
  • Traini, D., Rogueda, P., Young, P., Price, R. (2005). Surface Energy and Interparticle Force Correlation in Model pMDI Formulations. Pharmaceutical Research, 22(5), 816-825. [More Information]
  • Traini, D., Rogueda, P., Young, P., Price, R. (2005). Surface energy and interparticle forces correlations in model pMDI formulations. Pharmaceutical Research, 22(5), 816-25. [More Information]
  • Young, P., Edge, S., Traini, D., Jones, M., Price, R., El-Sabawi, D., Urry, C., Smith, C. (2005). The influence of dose on the performance of dry powder inhalation systems. International Journal of Pharmaceutics, 296(1-2), 26-33. [More Information]
  • Young, P., THOMPSON, J., Woodcock, D., AYDIN, M., Price, R. (2004). The Development of a Novel High-Dose Pressurized Aerosol Dry-Powder Device (PADD) for the Delivery of Pumactant for Inhalation Therapy. Journal of Aerosol Medicine, 17(2), 123-128.
  • Young, P., Price, R. (2004). The influence of humidity on the aerosolisation of micronised and SEDS produced salbutamol sulphate. European Journal of Pharmaceutical Sciences, 22(4), 235-240. [More Information]
  • Young, P., Price, R., Tobyn, M., Buttrum, M., DEY, F. (2004). The influence of relative humidity on the cohesion properties of micronized drugs used in inhalation therapy. Journal of Pharmaceutical Sciences, 93(3), 753-761. [More Information]
  • Steele, D., Young, P., Price, R., Smith, T., Edge, S., Lewis, D. (2004). The potential use of Raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers. The AAPS Journal, 6(4), Article 32 - 1-Article 32 - 4.
  • Ferrari, F., Cocconi, D., Bettini, R., Giordano, F., Santi, P., Tobyn, M., Price, R., Young, P., Caramella, C., Colombo, P. (2004). The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer. AAPS PharmSciTech, 5(4), 1 (article 60)-6.
  • Price, R., Young, P. (2004). Visualization of the crystallization of lactose from the amorphous state. Journal of Pharmaceutical Sciences, 93(1), 155-164. [More Information]
  • Young, P., Price, R., Tobyn, M., Buttrum, M., DEY, F. (2003). Effect of humidity on aerosolization of micronized drugs. Drug Development and Industrial Pharmacy, 29(9), 959-966.
  • Young, P., Booth, J., Price, R., Tobyn, M. (2003). Environmentally controlled optical microscopy for the pharmaceutical sciences,. Microscopy and Analysis, 17(3), 5-6.
  • Young, P., Price, R., Tobyn, M., Buttrum, M., DEY, F. (2003). Investigation into the effect of humidity on drug-drug interactions using the atomic force microscope. Journal of Pharmaceutical Sciences, 92(4), 815-822. [More Information]
  • BEGAT, P., Young, P., Edge, S., Kaerger, S., Price, R. (2003). The effect of mechanical processing on surface stability of pharmaceutical powders: Visualization by atomic force microscopy. Journal of Pharmaceutical Sciences, 92(3), 611-620. [More Information]
  • Young, P., Price, R., Lewis, D., Edge, S., Traini, D. (2003). Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope. Journal of Colloid and Interface Science, 262(1), 298-302.
  • Young, P., Cocconi, D., Colombo, P., Bettini, R., Price, R., Steele, D., Tobyn, M. (2002). Characterization of a surface modified dry powder inhalation carrier prepared by "particle smoothing". Journal of Pharmacy and Pharmacology, 54(10), 1339-1344.
  • Edge, S., Belu, A., Potter, U., Steele, D., Young, P., Price, R., Staniforth, J. (2002). Chemical characterisation of sodium starch glycolate particles. International Journal of Pharmaceutics, 240(1-2), 67-78.
  • Price, R., Young, P., Edge, S., Staniforth, J. (2002). The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations. International Journal of Pharmaceutics, 246(1-2), 47-59.
  • Hunt, D., Young, P., Simes, R., Hague, W., Mann, S., Owensby, D., Lane, G., Tonkin, A. (2001). Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients. Annals of Internal Medicine, (134), 931-940.

Conferences

  • Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of glycerol on the formation and morphology of particles generated from budesonide solution-based pressurized metered dose inhalers. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Chen, Y., Traini, D., Fletcher, D., Chan, H., Lewis, D., Church, T., Young, P. (2013). The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2013). Uptake of salmeterol xinafoate and fluticasone propionate from single and combination dry powder inhalers after deposition on calu-3 respiratory epithelia. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Chan, J., Chan, H., Young, P., Traini, D. (2012). An Inhaled Triple Antibiotic Dry Powder Formulation for the Treatment of Tuberculosis. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Ong, H., Cipolla, D., Gonda, I., Traini, D., Bebawy, M., Agus, H., Young, P. (2012). Inhaled Liposomal Ciprofloxacin Nanoparticles Control the Release of Antibiotic at the Bronchial Epithelia. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Chen, Y., Wong, W., Lewis, D., Church, T., Traini, D., Young, P. (2012). Triboelectrification Study of a Pressurized Metered Dose Inhaler (pMDI) Formulation Using Different Actuator Materials and Orifice Designs. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2011). Cellular Release Profiling of Controlled Release Dry Powder Pulmonary Formulations. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2011). Comparison of Albuterol Sulphate and Base Dry Powder Particulate Deposition Using the Calu-3 Lung Epithelial Model. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Jetmalani, K., Stewart, P., Traini, D., Young, P. (2011). Formulation and Characteristics of Combination Dry Powder Inhalation Therapy. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Young, P., Traini, D., Salama, R. (2011). In Vitro Techniques Equipped to Study Clinically Relevant Controlled Release Products. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D. (2011). Micronized drug powders in binary mixtures and the effect of physical properties on aerosolisation from combination drug dry powder inhalers. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Marin, L., Colombo, P., Buttini, F., Bebawy, M., Young, P., Traini, D. (2011). Multiple-dosing of Simvastatin Inhibits Mucus Production on the Calu-3 air interface cell model. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Traini, D., Young, P. (2011). Novel approaches to treating respiratory infection using antibiotic DPI systems. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Yang, M., Lee, Y., Wu, J., Young, P., Van den Berg, F., Rantanen, J. (2011). Polymorphism of Spray-Dried Mannitol as a Function of Particle Size: Effect of Lysozyme. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Haghi, M., Young, P., Traini, D., Bebawy, M. (2010). Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Valet, O., Lankers, M., Adi, H., Traini, D., Young, P. (2010). The Use of High Throughput Raman Microscopy for the Concurrent Size Determination and Chemical Characterization of Inhalation Particles. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Wong, W., Adi, H., Traini, D., Chan, H., Fletcher, D., Crapper, J., Young, P. (2010). Use of Rapid Prototyping and Computational Fluid Dynamics in the Design of DPI Devices. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Application of the Electrical Next Generation Impactor (eNGI) for the Electrostatic Characterization of Commercial Dry Powder Inhaler Formulations. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Wong, W., Traini, D., Chan, H., Crapper, J., Young, P. (2009). High Dose Respiratory Medicines: Pharmacopeia Methodologies for Determining Aerodynamic Mass Distributions. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Das, S., Larson, I., Young, P., Stewart, P. (2008). Change in Surface Energy of Lactoses After Storage at High Relative Humidity Determined by Inverse Gas Chromatography. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Hoe, S., Young, P., Chan, H., Traini, D. (2008). Electrical Next Generation Impactor (eNGI): A New Method for Aerosol Electrostatics. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Salama, R., Ladd, L., Traini, D., Chan, H., Young, P. (2008). Formulation, Characterization and In Vitro - In Vivo Evaluation of Spray Dried Pulmonary Microparticles in an Ovine Animal Model. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Parlati, C., Adi, H., Buttini, F., Colombo, P., Young, P., Traini, D. (2008). In Vitro Evaluation of Co-Processed Antibiotic for Inhalation. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D. (2008). Use of Scanning White Light Interferometry to Evaluate the Surface Roughness and Aerosol Performance of Spherical Micron-Sized Drug Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Young, P. (2007). Controlled release to the lung: the Holy Grail or wholly impossible? Australian Colloid and Interface Symposium.
  • Adi, H., Young, P., Chan, H., Traini, D., Stewart, P. (2007). Cospray dried antibiotics for dry powder inhalation delivery. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing. [More Information]
  • Young, P. (2006). Amorphous crystalline surface domains, do they exist and can we see them? Australasian Pharmaceutical Science Association (APSA).
  • Young, P., Shyamal, D., Larson, I., Stewart, P. (2006). Comparison of the surface energies of course and micronised lactose by inverse gas chromatography. Australasian Pharmaceutical Science Association (APSA).
  • Young, P., Price, A. (2006). Controlling and Measuring Active Sites on Carrier Particles. Respiratory Drug Delivery 2006, River Grove, Illinois 60171 USA: Davis Healthcare International Publishing.
  • Young, P., Adi, H., Stewart, P., Traini, D. (2006). Effect of modification of lactose on its surface energy characteristics. Australasian Pharmaceutical Science Association (APSA).
  • Young, P., Naderi, M., Traini, D., Thielmann, F. (2006). Impact of Lactose Polymorphism on Salbutamol Sulphate Lactose Interactions in DPI Formulations. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., Salama, R., Chan, H., Traini, D. (2006). Preparation and characterisation of controlled release microparticles for inhalation. Australasian Pharmaceutical Science Association (APSA).
  • Traini, D., Tee, H., Chiou, H., Chan, H., Young, P. (2006). The Effect of Mechanically Processed Pharmaceutical Carries for Dry Powder Inhalation on Drug Aerosolisation Performance. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Young, P., Chiou, H., Tee, E., Traini, D., Theilmann, F., Chan, H. (2006). The uses of a novel dynamic vapour sorption method to calculate low levels of amorphous content in lactose samples for dry powder inhaler formulations. Australasian Pharmaceutical Science Association (APSA).
  • Young, P., Price, A., Traini, D. (2005). Coarse carriers, active sites and sticky drugs. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2005). Investigating particle interactions in non-aqueous model suspensions by surface energy and AFM measurements. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • El-Sabawi, D., Young, P., Edge, S., Price, R. (2005). Investigation into the influence of storage conditions on the inhalation properties of novel surface etched lactose carriers for DPI formulations. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • El-Sabawi, D., Young, P., Edge, S., Price, R. (2005). Novel temperature controlled surface etching of excipient particles: investigation into the influence of storage conditions on inhalation properties of surface etched DPI formulations. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Young, P., Conway, J., Price, A., Woodcock, D. (2005). Patient friendly high dose dry powder inhaler delivery of Pumactant in seasonal asthma. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2005). The use of in vitro, AFM and surface energy measurements to predict pMDI aerosolisation performance. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Jones, M., Price, R., Young, P., Taylor, G., Rodrigues de Sousa Taylor, C., Kellaway, I. (2004). Correlation between the in vitro performance of spray-dried materials and AFM separation energy measurements. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2004). Study of particle adhesion to polymer coated pMDI canister walls: surface energy and AFM measurements. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.

Reference Works

  • Young, P. (2009). Ethylene Vinyl Acetate (sixth edition). In Raymond C Rowe, Paul J Sheskey and Marian E Quinn (Eds.), Handbook of Pharmaceutical Excipients (Sixth Edition). (pp. 268-269). Chicago, USA: Pharmaceutical Press.
  • Young, P. (2009). Sodium Starch Glycolate. In Raymond C Rowe, Paul J Sheskey, Marian E Quinn (Eds.), Handbook of Pharmaceutical Excipients. (pp. 663-666). Chicago, USA: Pharmaceutical Press.
  • Young, P., Edge, S. (2006). Ethylene Vinyl Acetate (fifth edition). In Raymond C Rowe, Paul J Sheskey and Sian C Owen (Eds.), Handbook of Pharaceutical Excipients. (Vol. 1, pp. 285-286). United Kingdom: Pharmaceutical Press.

2014

  • Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
  • Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
  • Ong, H., Traini, D., Ballerin, G., Morgan, L., Buddle, L., Scalia, S., Young, P. (2014). Combined inhaled salbutamol and mannitol therapy for mucus hyper-secretion in pulmonary diseases. The AAPS Journal, 16(2), 269-280. [More Information]
  • Salama, R., Young, P., Traini, D. (2014). Concurrent oral and inhalation drug delivery using a dual formulation system: the use of oral theophylline carrier with combined inhalable budesonide and terbutaline. Drug Delivery and Translational Research, 4(3), 256-267. [More Information]
  • Ong, H., Benaouda, F., Traini, D., Cipolla, D., Gonda, I., Bebawy, M., Forbes, B., Young, P. (2014). In vitro and ex vivo methods predict the enhanced lung residence time of liposomal ciprofloxacin formulations for nebulisation. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 83-89. [More Information]
  • Haghi, M., Traini, D., Young, P. (2014). In Vitro Cell Integrated Impactor Deposition Methodology for the Study of Aerodynamically Relevant Size Fractions from Commercial Pressurised Metered Dose Inhalers. Pharmaceutical Research, 31(7), 1779-1787. [More Information]
  • Niaz, M., Traini, D., Young, P., Ghadiri, M., Rohanizadeh, R. (2014). Investigation into physical-chemical variables affecting the manufacture and dissolution of wet-milled clarithromycin nanoparticles. Pharmaceutical Development and Technology, 19(8), 911-921. [More Information]
  • Ooi, J., Gaisford, S., Boyd, B., Young, P., Traini, D. (2014). Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems. International Journal of Pharmaceutics, 461(1-2), 301-309. [More Information]
  • Ooi, J., Gaisford, S., Boyd, B., Young, P., Traini, D. (2014). Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems. International Journal of Pharmaceutics, 461(1-2), 301-309. [More Information]
  • Young, P., Crapper, J., Gary, P., Sharma, K., Chan, H., Traini, D. (2014). Overcoming Dose Limitations Using the Orbital(®) Multi-Breath Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2), 138-147. [More Information]
  • Lee, W., Loo, J., Young, P., Traini, D., Mason, R., Rohanizadeh, R. (2014). Recent advances in curcumin nanoformulation for cancer therapy. Expert Opinion on Drug Delivery, 11(8), 1183-1201. [More Information]
  • DAVIS, S., Durvasula, S., Merhi, D., Young, P., Traini, D., Bosnic-Anticevich, S. (2014). Respiratory medication use in an Australian developmental disability clinic population: messages for health care professionals. Australian Journal of Primary Health, 20(30), 278-284. [More Information]
  • Loo, J., Young, P., Cavaliere, R., Whitchurch, C., Lee, W., Rohanizadeh, R. (2014). Silver nanoparticles enhance Pseudomonas aeruginosa PAO1 biofilm detachment. Drug Development and Industrial Pharmacy, 40(6), 719-729. [More Information]
  • Saadat, A., Zhu, B., Haghi, M., King, G., Colombo, G., Young, P., Traini, D. (2014). The formulation, chemical and physical characterisation of clarithromycin-based macrolide solution pressurised metered dose inhaler. Journal of Pharmacy and Pharmacology, 66(5), 639-645. [More Information]
  • Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2014). The Influence of Actuator Materials and Nozzle Designs on Electrostatic Charge of Pressurised Metered Dose Inhaler (pMDI) Formulations. Pharmaceutical Research, 31(5), 1325-1337. [More Information]
  • Zhu, B., Traini, D., Lewis, D., Young, P. (2014). The solid-state and morphological characteristics of particles generated from solution-based metered dose inhalers: Influence of ethanol concentration and intrinsic drug properties. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 443, 345-355. [More Information]
  • Lewis, D., Young, P., Buttini, F., Church, T., Colombo, P., Forbes, B., Haghi, M., Johnson, R., O'Shea, H., Salama, R., Traini, D. (2014). Towards the bioequivalence of pressurised metered dose inhalers 1: Design and characterisation of aerodynamically equivalent beclomethasone dipropionate inhalers with and without glycerol as a non-volatile excipient. European Journal of Pharmaceutics and Biopharmaceutics, 86, 31-37. [More Information]
  • Haghi, M., Bebawy, M., Colombo, P., Forbes, B., Lewis, D., Salama, R., Traini, D., Young, P. (2014). Towards the bioequivalence of pressurised metered dose inhalers 2. Aerodynamically equivalent particles (with and without glycerol) exhibit different biopharmaceutical profiles in vitro. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 38-45. [More Information]

2013

  • Chan, J., Chan, H., Prestidge, C., Denman, J., Young, P., Traini, D. (2013). A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 285-292. [More Information]
  • Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2013). Ciprofloxacin Is Actively Transported across Bronchial Lung Epithelial Cells Using a Calu-3 Air Interface Cell Model. Antimicrobial Agents and Chemotherapy, 57(6), 2535-2540. [More Information]
  • Scalia, S., Traini, D., Young, P., Di Sabatino, M., Passerini, N., Albertini, B. (2013). Comparison of spray congealing and melt emulsification methods for the incorporation of the water-soluble salbutamol sulphate in lipid microparticles. Pharmaceutical Development and Technology, 18(1), 266-273. [More Information]
  • Martínez, L., Betz, G., Villalobos, R., Melgoza, L., Young, P. (2013). Correlation between compactibility values and excipient cluster size using an in silico approach. Drug Development and Industrial Pharmacy, 39(2), 374-381. [More Information]
  • Haghi, M., Traini, D., Postma, D., Bebawy, M., Young, P. (2013). Fluticasone uptake across Calu-3 cells is mediated by salmeterol when deposited as a combination powder inhaler. Respirology, 18(8), 1197-1201. [More Information]
  • Traini, D., Young, P. (2013). Formulation of inhalation medicines. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 31-45). Chichester, UK: John Wiley & Sons.
  • Scalia, S., Trotta, V., Traini, D., Young, P., Sticozzi, C., Cervellati, F., Valacchi, G. (2013). Incorporation of quercetin in respirable lipid microparticles: Effect on stability and cellular uptake on A549 pulmonary alveolar epithelial cells. Colloids And Surfaces B: Biointerfaces, 112, 322-329. [More Information]
  • Traini, D., Young, P. (2013). Inhalation and nasal products. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 15-30). Chichester, UK: John Wiley & Sons.
  • Marin, L., Traini, D., Bebawy, M., Colombo, P., Buttini, F., Haghi, M., Ong, H., Young, P. (2013). Multiple dosing of simvastatin inhibits airway mucus production of epithelial cells: Implications in the treatment of chronic obstructive airway pathologies. European Journal of Pharmaceutics and Biopharmaceutics, 84(3), 566-572. [More Information]
  • Ong, H., Traini, D., Young, P. (2013). Pharmaceutical applications of the Calu-3 lung epithelia cell line. Expert Opinion on Drug Delivery, 10(9), 1287-1302. [More Information]
  • Scalia, S., Haghi, M., Losi, V., Trotta, V., Young, P., Traini, D. (2013). Quercetin solid lipid microparticles: A flavonoid for inhalation lung delivery. European Journal of Pharmaceutical Sciences, 49(2), 278-285. [More Information]
  • Mamlouk, M., Young, P., Bebawy, M., Haghi, M., Mamlouk, S., Mulay, V., Traini, D. (2013). Salbutamol Sulfate Absorption Across Calu-3 Bronchial Epithelia Cell Monolayer is Inhibited in the Presence of Common Anionic NSAIDs. Journal of Asthma, 50(4), 334-341. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug Development and Industrial Pharmacy, 39(11), 1625-1637. [More Information]
  • Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of glycerol on the formation and morphology of particles generated from budesonide solution-based pressurized metered dose inhalers. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Chen, Y., Traini, D., Fletcher, D., Chan, H., Lewis, D., Church, T., Young, P. (2013). The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
  • Ong, H., Traini, D., Salama, R., Anderson, S., Daviskas, E., Young, P. (2013). The Effects of Mannitol on the Transport of Ciprofloxacin across Respiratory Epithelia. Molecular Pharmaceutics, 10(8), 2915-2924. [More Information]
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2013). Uptake of salmeterol xinafoate and fluticasone propionate from single and combination dry powder inhalers after deposition on calu-3 respiratory epithelia. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.

2012

  • Chan, J., Chan, H., Young, P., Traini, D. (2012). An Inhaled Triple Antibiotic Dry Powder Formulation for the Treatment of Tuberculosis. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Adi, H., Young, P., Traini, D. (2012). Co-deposition of a triple therapy drug formulation for the treatment of chronic obstructive pulmonary disease using solution-based pressurised metered dose inhalers. Journal of Pharmacy and Pharmacology, 64(9), 1245-1253. [More Information]
  • Chan, J., Traini, D., Chan, H., Young, P., Kwok, P. (2012). Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(5), 297-305. [More Information]
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2012). Deposition, Diffusion and Transport Mechanism of Dry Powder Microparticulate Salbutamol, at the Respiratory Epithelia. Molecular Pharmaceutics, 9(6), 1717-1726. [More Information]
  • Ong, H., Cipolla, D., Gonda, I., Traini, D., Bebawy, M., Agus, H., Young, P. (2012). Inhaled Liposomal Ciprofloxacin Nanoparticles Control the Release of Antibiotic at the Bronchial Epithelia. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Ong, H., Traini, D., Cipolla, D., Gonda, I., Bebawy, M., Agus, H., Young, P. (2012). Liposomal Nanoparticles Control the Uptake of Ciprofloxacin Across Respiratory Epithelia. Pharmaceutical Research, 29(12), 3335-3346. [More Information]
  • Upadhyay, D., Scalia, S., Vogel, R., Wheate, N., Salama, R., Young, P., Traini, D., Chrzanowski, W. (2012). Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery. Pharmaceutical Research, 29(9), 2456-2467. [More Information]
  • Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D. (2012). Micronized drug powders in binary mixtures and the effect of physical properties on aerosolization from combination drug dry powder inhalers. Drug Development and Industrial Pharmacy, 38(12), 1504-1511. [More Information]
  • Haghi, M., Salama, R., Traini, D., Bebawy, M., Young, P. (2012). Modification of Disodium Cromoglycate Passage Across Lung Epithelium In Vitro Via Incorporation into Polymeric Microparticles. The AAPS Journal, 14(1), 79-86. [More Information]
  • Villalobos, R., Viquez, H., Hernandez, B., Ganem, A., Melgoza, L., Young, P. (2012). Parameters affecting drug release from inert matrices. 1: Monte Carlo simulation. Pharmaceutical Development and Technology, 17(3), 344-352. [More Information]
  • Traini, D., Scalia, S., Adi, H., Marangoni, E., Young, P. (2012). Polymer coating of carrier excipients modify aerosol performance of adhered drugs used in dry powder inhalation therapy. International Journal of Pharmaceutics, 438(1-2), 150-159. [More Information]
  • Traini, D., Adi, H., Valet, O., Young, P. (2012). Preparation and Evaluation of Single and Co-Engineered Combination Inhalation Carrier Formulations for the Treatment of Asthma. Journal of Pharmaceutical Sciences, 101(11), 4267-4276. [More Information]
  • Scalia, S., Salama, R., Young, P., Traini, D. (2012). Preparation and in vitro evaluation of salbutamol-loaded lipid microparticles for sustained release pulmonary therapy. Journal of Microencapsulation, 29(3), 225-233. [More Information]
  • Loo, J., Young, P., Lee, W., Cavaliere, R., Whitchurch, C., Rohanizadeh, R. (2012). Superhydrophobic, nanotextured polyvinyl chloride films for delaying Pseudomonas aeruginosa attachment to intubation tubes and medical plastics. Acta Biomaterialia, 8(5), 1881-1890. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Young, P. (2012). The use of computational approaches in inhaler development. Advanced Drug Delivery Reviews, 64(4), 312-322. [More Information]
  • Jones, M., Young, P., Traini, D. (2012). The use of inverse gas chromatography for the study of lactose and pharmaceutical materials used in dry powder inhalers. Advanced Drug Delivery Reviews, 64(3), 285-293. [More Information]
  • Chen, Y., Wong, W., Lewis, D., Church, T., Traini, D., Young, P. (2012). Triboelectrification Study of a Pressurized Metered Dose Inhaler (pMDI) Formulation Using Different Actuator Materials and Orifice Designs. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
  • Rogueda, P., Lallement, A., Traini, D., Iliev, I., Young, P. (2012). Twenty years of HFA pMDI patents: facts and perspectives. Journal of Pharmacy and Pharmacology, 64(9), 1209-1216. [More Information]

2011

  • Hoe, S., Young, P., Traini, D. (2011). A Review of Electrostatic Measurement Techniques for Aerosol Drug Delivery to the Lung: Implications in Aerosol Particle Deposition. Journal of Adhesion Science and Technology, 25(4-5), 385-405. [More Information]
  • Salama, R., Young, P., Rogueda, P., Lallement, A., Iliev, I., Traini, D. (2011). Advances in drug delivery: is triple therapy the future for the treatment of chronic obstructive pulmonary disease? Expert Opinion on Pharmacotherapy, 12(12), 1913-1932. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). Aerosol tribocharging and its relation to the deposition of Oxis Turbuhaler in the electrical next generation impactor. Journal of Pharmaceutical Sciences, 100(12), 5270-5280. [More Information]
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2011). Cellular Release Profiling of Controlled Release Dry Powder Pulmonary Formulations. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Marin, L., Colombo, P., Bebawy, M., Young, P., Traini, D. (2011). Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management. Expert Opinion on Drug Delivery, 8(9), 1205-1220. [More Information]
  • Haghi, M., Traini, D., Bebawy, M., Young, P. (2011). Comparison of Albuterol Sulphate and Base Dry Powder Particulate Deposition Using the Calu-3 Lung Epithelial Model. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Ooi, J., Traini, D., Hoe, S., Wong, W., Young, P. (2011). Does carrier size matter? A fundamental study of drug aerosolisation from carrier based dry powder inhalation systems. International Journal of Pharmaceutics, 413(1-2 (Feb)), 1-9. [More Information]
  • Hoe, S., Young, P., Traini, D. (2011). Dynamic electrostatic charge of lactose-salbutamol sulphate powder blends dispersed from a Cyclohaler. Drug Development and Industrial Pharmacy, 37(11), 1365-1375. [More Information]
  • Ong, H., Traini, D., Bebawy, M., Young, P. (2011). Epithelial Profiling of Antibiotic Controlled Release Respiratory Formulations. Pharmaceutical Research, 28(9), 2327-2338. [More Information]
  • Jetmalani, K., Stewart, P., Traini, D., Young, P. (2011). Formulation and Characteristics of Combination Dry Powder Inhalation Therapy. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Young, P., Traini, D., Salama, R. (2011). In Vitro Techniques Equipped to Study Clinically Relevant Controlled Release Products. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
  • Jetmalani, K., Young, P., Smith, T., Stewart, P., Traini, D. (2011). Micronized drug powders in binary mixtures and the effect of physical properties on aerosolisation from combination drug dry powder inhalers. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Abdel-Halim, H., Traini, D., Hibbs, D., Gaisford, S., Young, P. (2011). Modelling of molecular phase transitions in pharmaceutical inhalation compounds: an in silico approach. European Journal of Pharmaceutics and Biopharmaceutics, 78(1), 83-89. [More Information]
  • Marin, L., Colombo, P., Buttini, F., Bebawy, M., Young, P., Traini, D. (2011). Multiple-dosing of Simvastatin Inhibits Mucus Production on the Calu-3 air interface cell model. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Traini, D., Young, P. (2011). Novel approaches to treating respiratory infection using antibiotic DPI systems. Drug Delivery to the Lungs 22 (DDL22), Portishead, North Somerset, United Kingdom: The Aerosol Society.
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-Up in Dry Powder Inhalers: Evaluation and Modelling of Impaction Effects for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(7), 2744-2754. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-up in Dry Powder Inhalers: Evaluation and Modelling of the Influence of Grid Structures for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(11), 4710-4721. [More Information]
  • Lee, Y., Wu, J., Yang, M., Young, P., Van den Berg, F., Rantanen, J. (2011). Particle size dependence of polymorphism in spray-dried mannitol. European Journal of Pharmaceutical Sciences, 44(1-2), 41-48. [More Information]
  • Rogueda, P., Price, R., Smith, T., Young, P., Traini, D. (2011). Particle synergy and aerosol performance in non-aqueous liquid of two combinations metered dose inhalation formulations: an AFM and Raman investigation. Journal of Colloid and Interface Science, 361(2), 649-655. [More Information]
  • Yang, M., Lee, Y., Wu, J., Young, P., Van den Berg, F., Rantanen, J. (2011). Polymorphism of Spray-Dried Mannitol as a Function of Particle Size: Effect of Lysozyme. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
  • Young, P., Wood, O., Ooi, J., Traini, D. (2011). The influence of drug loading on formulation structure and aerosol performance in carrier based dry powder inhalers. International Journal of Pharmaceutics, 416(1), 129-135. [More Information]

2010

  • Strusi, O., Barata, P., Traini, D., Young, P., Mercuri, S., Colombo, G., Sonvico, F., Bettini, R., Colombo, P. (2010). Artesunate-clindamycin multi-kinetics and site-specific oral delivery system for antimalaric combination products. Journal of Controlled Release, 146(1), 54-60. [More Information]
  • Haghi, M., Young, P., Traini, D., Bebawy, M. (2010). Characterization of P-gp Expression and Function vs. Time and Passage in the Calu-3 Air-Interface Model for Drug Delivery to the Lung. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Adi, H., Young, P., Chan, H., Agus, H., Traini, D. (2010). Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European Journal of Pharmaceutical Sciences, 40, 239-247. [More Information]
  • Adi, H., Young, P., Chan, H., Salama, R., Traini, D. (2010). Controlled release antibiotics for dry powder lung delivery. Drug Development and Industrial Pharmacy, 36(1), 119-126. [More Information]
  • Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2010). Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems. Pharmaceutical Research, 27(7), 1367-1376. [More Information]
  • Wong, W., Crapper, J., Chan, H., Traini, D., Young, P. (2010). Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of Pharmaceutical and Biomedical Analysis, 51(4), 853-857. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2010). The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems. Pharmaceutical Research, 27(7), 1325-1336. [More Information]
  • Valet, O., Lankers, M., Adi, H., Traini, D., Young, P. (2010). The Use of High Throughput Raman Microscopy for the Concurrent Size Determination and Chemical Characterization of Inhalation Particles. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
  • Haghi, M., Young, P., Traini, D., Jaiswal, R., Gong, J., Bebawy, M. (2010). Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model. Drug Development and Industrial Pharmacy, 36(10), 1207-1214. [More Information]
  • Das, S., Larson, I., Young, P., Stewart, P. (2010). Understanding lactose behaviour during storage by monitoring surface energy change using inverse gas chromatography. Dairy Science and Technology, 90(2-3), 271-285. [More Information]
  • Wong, W., Adi, H., Traini, D., Chan, H., Fletcher, D., Crapper, J., Young, P. (2010). Use of Rapid Prototyping and Computational Fluid Dynamics in the Design of DPI Devices. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.

2009

  • Das, S., Larson, I., Young, P., Stewart, P. (2009). Agglomerate properties and dispersibility changes of salmeterol xinafoate from powders for inhalation after storage at high relative humidity. European Journal of Pharmaceutical Sciences, 37(3-4), 442-450. [More Information]
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Application of the Electrical Next Generation Impactor (eNGI) for the Electrostatic Characterization of Commercial Dry Powder Inhaler Formulations. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Traini, D., Young, P. (2009). Delivery of antibiotics to the respiratory tract: an update. Expert Opinion on Drug Delivery, 6(9), 897-905. [More Information]
  • Salama, R., Ladd, L., Chan, H., Traini, D., Young, P. (2009). Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. The AAPS Journal, 11(3), 465-468. [More Information]
  • Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
  • Young, P. (2009). Ethylene Vinyl Acetate (sixth edition). In Raymond C Rowe, Paul J Sheskey and Marian E Quinn (Eds.), Handbook of Pharmaceutical Excipients (Sixth Edition). (pp. 268-269). Chicago, USA: Pharmaceutical Press.
  • Wong, W., Traini, D., Chan, H., Crapper, J., Young, P. (2009). High Dose Respiratory Medicines: Pharmacopeia Methodologies for Determining Aerodynamic Mass Distributions. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
  • Das, S., Larson, I., Young, P., Stewart, P. (2009). Influence of Storage Relative Humidity on the Dispersion of Salmeterol Xinafoate Powders for Inhalation. Journal of Pharmaceutical Sciences, 98(3), 1015-1027. [More Information]
  • Hoe, S., Young, P., Chan, H., Traini, D. (2009). Introduction of the Electrical Next Generation Impactor (eNGI) and Investigation of its Capabilities for the Study of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 26(2), 431-437. [More Information]
  • Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences, 38, 88-94. [More Information]
  • Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
  • Parlati, C., Colombo, P., Buttini, F., Young, P., Adi, H., Ammit, A., Traini, D. (2009). Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency. Pharmaceutical Research, 26(5), 1084-1092. [More Information]
  • Dalby, R., Byron, P., Peart, J., Suman, J., Young, P. (2009). RDD Europe 2009: Respiratory Drug Delivery. United States: Davis Healthcare International Publishing.
  • Salama, R., Traini, D., Chan, H., Young, P. (2009). Recent Advances in Controlled Release Pulmonary Therapy. Current Drug Delivery, 6(4), 404-414. [More Information]
  • Young, P. (2009). Sodium Starch Glycolate. In Raymond C Rowe, Paul J Sheskey, Marian E Quinn (Eds.), Handbook of Pharmaceutical Excipients. (pp. 663-666). Chicago, USA: Pharmaceutical Press.
  • Mezzena, M., Scalia, S., Young, P., Traini, D. (2009). Solid Lipid Budesonide Microparticles for Controlled Release Inhalation Therapy. The AAPS Journal, 11(4), 771-778. [More Information]
  • Das, S., Larson, I., Young, P., Stewart, P. (2009). Surface energy changes and their relationship with the dispersibility of salmeterol xinafoate powders for inhalation after storage at high RH. European Journal of Pharmaceutical Sciences, 38(4), 347-354. [More Information]
  • Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
  • Hoe, S., Traini, D., Chan, H., Young, P. (2009). The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers. Pharmaceutical Research, 26(12), 2639-2646. [More Information]
  • Young, P., Adi, H., Patel, T., Law, K., Rogueda, P., Traini, D. (2009). The influence of micronised particulates on the aerosolisation properties of pressurised metered dose inhalers. Journal of Aerosol Science, 40, 324-337. [More Information]

2008

  • Young, P., Traini, D., Edge, S. (2008). Advances in Pulmonary Therapy. In Williams, Taft and McConville (Eds.), Advanced Drug Formulation Design to Optimize Therapeutic Outcome, (pp. 1-51). USA: Informa Healthcare.
  • Das, S., Larson, I., Young, P., Stewart, P. (2008). Change in Surface Energy of Lactoses After Storage at High Relative Humidity Determined by Inverse Gas Chromatography. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Young, P., Price, R. (2008). Comparative measurement of pressurised metered dose inhaler (pMDI) stem displacement. Drug Development and Industrial Pharmacy, 34(1), 90-94. [More Information]
  • Young, P., Roberts, D., Chiou, H., Rae, W., Chan, H., Traini, D. (2008). Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science, 39, 82-93. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2008). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, 97(8), 3356-3366. [More Information]
  • Hoe, S., Young, P., Rogueda, P., Traini, D. (2008). Determination of reference ultrasound parameters for model and hydrofluoroalkane propellants using high-resolution ultrasonic spectroscopy. AAPS PharmSciTech, 9(2), 605-611. [More Information]
  • Hoe, S., Young, P., Chan, H., Traini, D. (2008). Electrical Next Generation Impactor (eNGI): A New Method for Aerosol Electrostatics. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Salama, R., Ladd, L., Traini, D., Chan, H., Young, P. (2008). Formulation, Characterization and In Vitro - In Vivo Evaluation of Spray Dried Pulmonary Microparticles in an Ovine Animal Model. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Parlati, C., Adi, H., Buttini, F., Colombo, P., Young, P., Traini, D. (2008). In Vitro Evaluation of Co-Processed Antibiotic for Inhalation. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information]
  • Young, P., Nguyen, K., Jones, A., Traini, D. (2008). Microstructural Analysis of Porous Composite Materials: Dynamic Imaging of Drug Dissolution and Diffusion Through Porous Matrices. The AAPS Journal, DOI: 10.1208/s12248-008-9063-2(Print version 2008 Vol. 10 pp. 560-564), 1-5. [More Information]
  • Salama, R., Hoe, S., Chan, H., Traini, D., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 486-495. [More Information]
  • Salama, R., Traini, D., Chan, H., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 145-152. [More Information]
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2008). Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences, 97(8), 3140-3152.
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D., Yang, R., Yu, A. (2008). Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir, 24(19), 11307-11312. [More Information]
  • Steele, D., Moreton, R., Staniforth, J., Young, P., Tobyn, M., Edge, S. (2008). Surface Energy of Microcrystalline Cellulose Determined by Capillary Intrusion and Inverse Gas Chromatography. The AAPS Journal, 10(3), 494-503. [More Information]
  • Traini, D., Young, P., Thielmann, F., Acharya, M. (2008). The influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulations. Drug Development and Industrial Pharmacy, 34(9), 992-1001. [More Information]
  • Jones, M., Young, P., Traini, D., Shur, J., Edge, S., Price, R. (2008). The use of atomic force microscopy to study the conditioning of micronised budesonide. International Journal of Pharmaceutics, 357(1-2), 314-317. [More Information]
  • Adi, S., Adi, H., Chan, H., Young, P., Traini, D. (2008). Use of Scanning White Light Interferometry to Evaluate the Surface Roughness and Aerosol Performance of Spherical Micron-Sized Drug Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
  • Traini, D., Loreti, G., Jones, A., Young, P. (2008). X-Ray Computed Microtomography for the Study of Modified Release Systems. Microscopy and Analysis, 22(1), 13-15.

2007

  • Young, P. (2007). Controlled release to the lung: the Holy Grail or wholly impossible? Australian Colloid and Interface Symposium.
  • Adi, H., Young, P., Chan, H., Traini, D., Stewart, P. (2007). Cospray dried antibiotics for dry powder inhalation delivery. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing. [More Information]
  • Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2007). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, online(DOI 10.1002/jps.21239), 1-11. [More Information]
  • Chan, H., Young, P., Traini, D., Coates, M. (2007). Dry powder inhalers: challenges and goals for next generation therapies. Pharmaceutical Technology Europe, 19(4), 19-24.
  • Young, P., Edge, S., Staniforth, J., Steele, D., Traini, D., Price, R. (2007). Effect of Moisture on the Compressibility and Compactibility of Sodium Starch Glycolate. Pharmaceutical Development and Technology, 12(2), 217-222.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2007). In Vitro Investigation of Drug Particulates Interactions and Aerosol Performance of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 24(1), 125-135. [More Information]
  • Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
  • Young, P., Edge, S., Staniforth, J., Steele, D., Price, R. (2007). Interaction of Moisture with Sodium Starch Glycolate. Pharmaceutical Development and Technology, 12(2), 211-216. [More Information]
  • Young, P., Traini, D., Coates, M., Chan, H. (2007). Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, 394(2), 315-319.
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2007). Role of agglomeration in the dispersion of salmeterol xinafoate from mixtures for inhalation with differing drug to fine lactose ratios. Journal of Pharmaceutical Sciences, 97(8), 3140-3152. [More Information]
  • Adi, H., Traini, D., Chan, H., Young, P. (2007). The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Sciences, Published online DOI 10.1002/jps.21195(Print version 2008 VOL. 97, NO. 7), 2780-2788. [More Information]
  • Young, P., Chan, H., Chiou, H., Edge, S., Tee, H., Traini, D. (2007). The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of Pharmaceutical Sciences, 96(5), 1331-1341. [More Information]
  • Young, P., Chiou, H., Tee, H., Traini, D., Chan, H., Thielmann, F., Burnett, D. (2007). The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, 33(1), 91-97. [More Information]

2006

  • Traini, D., Young, P., Price, R., Rogueda, P. (2006). A novel apparatus for the determination of solubility in pressurized metered dose inhalers. Drug Development and Industrial Pharmacy, 32(10), 1159-1163. [More Information]
  • Adi, H., Larson, I., Chiou, H., Young, P., Traini, D., Stewart, P. (2006). Agglomerate Strength and Dispersion of Salmeterol Xinafoate from Powder Mixtures for Inhalation. Pharmaceutical Research, 23(11), 2556-2565. [More Information]
  • Young, P. (2006). Amorphous crystalline surface domains, do they exist and can we see them? Australasian Pharmaceutical Science Association (APSA).
  • Kaerger, J., Price, R., Young, P., Edge, S., Tobyn, M. (2006). Carriers for DPIs: Formulation and regulatory challenges. Pharmaceutical Technology Europe, 18(10), 25-30.
  • Traini, D., Young, P., Jones, M., Edge, S., Price, R. (2006). Comparative study of erythritol and lactose monohydrate as carriers for inhalation: atomic force microscopy and in vitro correlation. European Journal of Pharmaceutical Sciences, 27(2-3), 243-251. [More Information]
  • Young, P., Shyamal, D., Larson, I., Stewart, P. (2006). Comparison of the surface energies of course and micronised lactose by inverse gas chromatography. Australasian Pharmaceutical Science Association (APSA).
  • El-Sabawi, D., Edge, S., Price, R., Young, P. (2006). Continued investigation into the influence of loaded dose on the performance of dry powder inhalers: Surface smoothing effects. Drug Development and Industrial Pharmacy, 32(10), 1135-1138. [More Information]
  • Young, P., Price, A. (2006). Controlling and Measuring Active Sites on Carrier Particles. Respiratory Drug Delivery 2006, River Grove, Illinois 60171 USA: Davis Healthcare International Publishing.
  • Burnett, D., Thielmann, F., Young, P. (2006). Determination of the amorphous content in excipients and drugs. Journal of Pharmacy and Pharmacology, 58(supplement 1), A21 (abstract 53)-A21.
  • Young, P., Adi, H., Stewart, P., Traini, D. (2006). Effect of modification of lactose on its surface energy characteristics. Australasian Pharmaceutical Science Association (APSA).
  • Young, P., Edge, S. (2006). Ethylene Vinyl Acetate (fifth edition). In Raymond C Rowe, Paul J Sheskey and Sian C Owen (Eds.), Handbook of Pharaceutical Excipients. (Vol. 1, pp. 285-286). United Kingdom: Pharmaceutical Press.
  • Young, P., Naderi, M., Traini, D., Thielmann, F. (2006). Impact of Lactose Polymorphism on Salbutamol Sulphate Lactose Interactions in DPI Formulations. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Thielmann, F., Young, P. (2006). Impact of lactose polymorphism on salbutamol sulphate-lactose interactions in DPI formulations. Journal of Pharmacy and Pharmacology, 58(supplement 1), A20 (abstract 52)-A21.
  • Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2006). Investigation into the influence of polymeric stabilizing excipients on inter-particulate forces in pressurised metered dose inhalers. International Journal of Pharmaceutics, 320(1-2), 58-63. [More Information]
  • El-Sabawi, D., Price, R., Edge, S., Young, P. (2006). Novel temperature controlled surface dissolution of excipient particles for carrier based dry powder inhaler formulations. Drug Development and Industrial Pharmacy, 32(2), 243-251. [More Information]
  • Young, P., Salama, R., Chan, H., Traini, D. (2006). Preparation and characterisation of controlled release microparticles for inhalation. Australasian Pharmaceutical Science Association (APSA).
  • Traini, D., Tee, H., Chiou, H., Chan, H., Young, P. (2006). The Effect of Mechanically Processed Pharmaceutical Carries for Dry Powder Inhalation on Drug Aerosolisation Performance. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
  • Traini, D., Young, P., Rogueda, P., Price, R. (2006). The use of AFM and surface energy measurements to investigate drug-canister material interactions in a model pressurized metered dose inhaler formulation. Aerosol Science and Technology, 40(4), 227-236.
  • Young, P., Tobyn, M., Price, R., Buttrum, M., DEY, F. (2006). The Use of Colloid Probe Microscopy to Predict Aerosolization Performance in Dry Powder Inhalers: AFM and In Vitro Correlation. Journal of Pharmaceutical Sciences, 95(8), 1800-1809. [More Information]
  • Young, P., Chiou, H., Tee, E., Traini, D., Theilmann, F., Chan, H. (2006). The uses of a novel dynamic vapour sorption method to calculate low levels of amorphous content in lactose samples for dry powder inhaler formulations. Australasian Pharmaceutical Science Association (APSA).

2005

  • Young, P., Price, A., Traini, D. (2005). Coarse carriers, active sites and sticky drugs. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Young, P., Edge, S., Staniforth, J., Steele, D., Price, R. (2005). Dynamic vapor sorption properties of sodium starch glycolate disintegrants. Pharmaceutical Development and Technology, 10(2), 249-259.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2005). Investigating particle interactions in non-aqueous model suspensions by surface energy and AFM measurements. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • El-Sabawi, D., Young, P., Edge, S., Price, R. (2005). Investigation into the influence of storage conditions on the inhalation properties of novel surface etched lactose carriers for DPI formulations. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • El-Sabawi, D., Young, P., Edge, S., Price, R. (2005). Novel temperature controlled surface etching of excipient particles: investigation into the influence of storage conditions on inhalation properties of surface etched DPI formulations. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Price, R., Young, P. (2005). On the physical transformations of processed pharmaceutical solids. Micron, 36(6), 519-524.
  • Young, P., Conway, J., Price, A., Woodcock, D. (2005). Patient friendly high dose dry powder inhaler delivery of Pumactant in seasonal asthma. 15th International Society for Aerosols in Medicine Conference (ISAM), United States: Mary Ann Liebert, Inc.
  • Traini, D., Rogueda, P., Young, P., Price, R. (2005). Surface Energy and Interparticle Force Correlation in Model pMDI Formulations. Pharmaceutical Research, 22(5), 816-825. [More Information]
  • Traini, D., Rogueda, P., Young, P., Price, R. (2005). Surface energy and interparticle forces correlations in model pMDI formulations. Pharmaceutical Research, 22(5), 816-25. [More Information]
  • Young, P., Edge, S., Traini, D., Jones, M., Price, R., El-Sabawi, D., Urry, C., Smith, C. (2005). The influence of dose on the performance of dry powder inhalation systems. International Journal of Pharmaceutics, 296(1-2), 26-33. [More Information]
  • Young, P., Traini, D., Rogueda, P., Price, A. (2005). The use of in vitro, AFM and surface energy measurements to predict pMDI aerosolisation performance. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.

2004

  • Jones, M., Price, R., Young, P., Taylor, G., Rodrigues de Sousa Taylor, C., Kellaway, I. (2004). Correlation between the in vitro performance of spray-dried materials and AFM separation energy measurements. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., Traini, D., Rogueda, P., Price, A. (2004). Study of particle adhesion to polymer coated pMDI canister walls: surface energy and AFM measurements. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
  • Young, P., THOMPSON, J., Woodcock, D., AYDIN, M., Price, R. (2004). The Development of a Novel High-Dose Pressurized Aerosol Dry-Powder Device (PADD) for the Delivery of Pumactant for Inhalation Therapy. Journal of Aerosol Medicine, 17(2), 123-128.
  • Young, P., Price, R. (2004). The influence of humidity on the aerosolisation of micronised and SEDS produced salbutamol sulphate. European Journal of Pharmaceutical Sciences, 22(4), 235-240. [More Information]
  • Young, P., Price, R., Tobyn, M., Buttrum, M., DEY, F. (2004). The influence of relative humidity on the cohesion properties of micronized drugs used in inhalation therapy. Journal of Pharmaceutical Sciences, 93(3), 753-761. [More Information]
  • Steele, D., Young, P., Price, R., Smith, T., Edge, S., Lewis, D. (2004). The potential use of Raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers. The AAPS Journal, 6(4), Article 32 - 1-Article 32 - 4.
  • Ferrari, F., Cocconi, D., Bettini, R., Giordano, F., Santi, P., Tobyn, M., Price, R., Young, P., Caramella, C., Colombo, P. (2004). The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer. AAPS PharmSciTech, 5(4), 1 (article 60)-6.
  • Price, R., Young, P. (2004). Visualization of the crystallization of lactose from the amorphous state. Journal of Pharmaceutical Sciences, 93(1), 155-164. [More Information]

2003

  • Young, P., Price, R., Tobyn, M., Buttrum, M., DEY, F. (2003). Effect of humidity on aerosolization of micronized drugs. Drug Development and Industrial Pharmacy, 29(9), 959-966.
  • Young, P., Booth, J., Price, R., Tobyn, M. (2003). Environmentally controlled optical microscopy for the pharmaceutical sciences,. Microscopy and Analysis, 17(3), 5-6.
  • Young, P., Price, R., Tobyn, M., Buttrum, M., DEY, F. (2003). Investigation into the effect of humidity on drug-drug interactions using the atomic force microscope. Journal of Pharmaceutical Sciences, 92(4), 815-822. [More Information]
  • BEGAT, P., Young, P., Edge, S., Kaerger, S., Price, R. (2003). The effect of mechanical processing on surface stability of pharmaceutical powders: Visualization by atomic force microscopy. Journal of Pharmaceutical Sciences, 92(3), 611-620. [More Information]
  • Young, P., Price, R., Lewis, D., Edge, S., Traini, D. (2003). Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope. Journal of Colloid and Interface Science, 262(1), 298-302.

2002

  • Young, P., Cocconi, D., Colombo, P., Bettini, R., Price, R., Steele, D., Tobyn, M. (2002). Characterization of a surface modified dry powder inhalation carrier prepared by "particle smoothing". Journal of Pharmacy and Pharmacology, 54(10), 1339-1344.
  • Edge, S., Belu, A., Potter, U., Steele, D., Young, P., Price, R., Staniforth, J. (2002). Chemical characterisation of sodium starch glycolate particles. International Journal of Pharmaceutics, 240(1-2), 67-78.
  • Price, R., Young, P., Edge, S., Staniforth, J. (2002). The influence of relative humidity on particulate interactions in carrier-based dry powder inhaler formulations. International Journal of Pharmaceutics, 246(1-2), 47-59.

2001

  • Hunt, D., Young, P., Simes, R., Hague, W., Mann, S., Owensby, D., Lane, G., Tonkin, A. (2001). Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients. Annals of Internal Medicine, (134), 931-940.

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