Dr Peregrine Osborne

Honorary Senior Research Fellow
Pain Medicine, Northern Clinical School

Telephone +61 3 9035 9716
Fax +61 3 9347 5219

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Research interests

Pain processing, neuropathic pain, and the molecular neuropharmacology of opioids and other analgesic drugs

Selected grants

2012

  • Spinal cord injury pain: understanding mechanisms to develop treatments; Keast J, Osborne P; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • High resolution mapping of lower urinary tract innervation during development; Keast J, Osborne P; National Institutes of Health (USA)/Research Support.
  • Can persistent bladder pain be treated by targeting TRPA1 expressing nociceptors?; Osborne P, Keast J; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Electrophysiology of Bladder Sensory Neurones; Osborne P; DVC Research/Bridging Support Grant.

2008

  • Experimental strategies for preventing persistent postsurgical pain; Cousins M, Osborne P; Australian and New Zealand College of Anaesthetists/Research Project Grant.
  • Real-time cellular imaging system; Connor M, Keast J, Vaughan C, Christie M, Osborne P, Bagley E, Sue C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2005

  • Pain following spinal cord injury: understanding mechanisms to develop treatments.; Keast J, Siddall P, Cousins M, Osborne P, Christie M; NSW Ministry of Science and Medical Research/Spinal Cord Injury Research Grants.
  • Cellular Mechanisms Of Tolerance To Opioid Analgesics In Sensory Dorsal Root Ganglia Neurons; Osborne P, Cousins M; ANZ Coll Anaesthetists (ANZCA)/Research Funding Scheme.
  • Effects of estrogens on bladder pain; Keast J, Osborne P; National Institutes of Health (USA)/National Institute of Diabetes and Digestive & Kidney Diseases.

2001

  • Forebrain neuroadaptations to chronic morphine treatment; Osborne P; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Forrest, S., Osborne, P., Keast, J. (2014). Characterisation of axons expressing the artemin receptor in the female rat urinary bladder: A comparison with other major neuronal populations. The Journal of Comparative Neurology, 522(17), 3900-3927. [More Information]
  • Forrest, S., Osborne, P., Keast, J. (2013). Characterization of bladder sensory neurons in the context of myelination, receptors for pain modulators, and acute responses to bladder inflammation. Frontiers in Neuroscience, 7, 1-12. [More Information]
  • O'Mullane, L., Keast, J., Osborne, P. (2013). Co-Cultures Provide a New Tool to Probe Communication Between Adult Sensory Neurons and Urothelium. The Journal of Urology, 190(2), 737-745. [More Information]
  • Densmore, V., Kalous, A., Keast, J., Osborne, P. (2010). Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. Pain, 151(1), 184-193. [More Information]
  • Keast, J., Forrest, S., Osborne, P. (2010). Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors. The Journal of Comparative Neurology, 518(15), 3024-3045. [More Information]
  • Hamlin, A., McNally, G., Westbrook, R., Osborne, P. (2009). Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine. Neuropharmacology, 56(4), 798-807. [More Information]
  • Kalous, A., Osborne, P., Keast, J. (2009). Spinal cord compression injury in adult rats initiates changes in dorsal horn remodeling that may correlate with development of neuropathic pain. The Journal of Comparative Neurology, 513(6), 668-684. [More Information]
  • Xu, S., Cheng, Y., Keast, J., Osborne, P. (2008). 17{beta}-Estradiol activates Estrogen Receptor{beta} signalling and inhibits Transient Receptor Potential Vanilloid Receptor 1 activation by capsaicin in adult rat nociceptor neurons. Endocrinology, 149(11), 5540-5548. [More Information]
  • Chieng, B., Lee, D., Du, Y., Osborne, P., Christie, M., Massottec, D. (2008). Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells. NeuroReport, 19(18), 1793-1796. [More Information]
  • Kalous, A., Osborne, P., Keast, J. (2007). Acute and chronic changes in dorsal horn innervation by primary afferents and descending supraspinal pathways after spinal cord injury. The Journal of Comparative Neurology, 504(3), 238-253. [More Information]
  • Marchant, N., Densmore, V., Osborne, P. (2007). Coexpression of prodynorphin and corticotrophin-releasing hormone in the rat central amygdala: Evidence of two distinct endogenous opioid systems in the lateral division. The Journal of Comparative Neurology, 504(6), 702-715. [More Information]
  • Hamlin, A., McNally, G., Osborne, P. (2007). Induction of c-Fos and zif268 in the nociceptive amygdala parallel abstinence hyperalgesia in rats briefly exposed to morphine. Neuropharmacology, 53(2), 330-343. [More Information]
  • Chieng, B., Christie, M., Osborne, P. (2006). Characterization of neurons in the rat central nucleus of the amygdala: Cellular physiology, morphology, and opioid sensitivity. The Journal of Comparative Neurology, 497(6), 910-927. [More Information]
  • Buller, K., Hamlin, A., Osborne, P. (2005). Dissection of peripheral and central endogenous opioid modulation of systemic interleukin-1beta responses using c-fos expression in the rat brain. Neuropharmacology, 49(2), 230-242. [More Information]
  • Osborne, P., Halliday, G., Cooper, H., Keast, J. (2005). Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. Neuroscience, 131(3), 671-681. [More Information]
  • Hamlin, A., Buller, K., Day, T., Osborne, P. (2004). Effect Of Naloxone-Precipitated Morphine Withdrawal On C-Fos Expression In Rat Corticotropin-Releasing Hormone Neurons In The Paraventricular Hypothalamus And Extended Amygdala. Neuroscience Letters, 362(1), 39-43.
  • Connor, M., Osborne, P., Christie, M. (2004). Mu-Opioid Receptor Desentization: Is Morphine Different? British Journal of Pharmacology, 143(6), 685-696.
  • Bengtson, C., Lee, D., Osborne, P. (2004). Opposing Electrophysiological Actions Of 5-Ht On Noncholinergic And Cholinergic Neurons In The Rat Ventral Pallidum In Vitro. Journal of Neurophysiology, 92(1), 433-443.
  • Kanjhan, R., Osborne, P., Ouyang, M., Keast, J. (2003). Postnatal maturational changes in rat pelvic autonomic ganglion cells: a mixture of steroid-dependent and -independent effects. Journal of Neurophysiology, 89(1), 315-323.
  • Osborne, P., Vidovic, M., Chieng, B., Hill, C., Christie, M. (2002). Expression of mRNA and functional alpha1-adrenoceptors that supress the GIRK conductance in adult rat locus coeruleus neurons. British Journal of Pharmacology, 13(1), 226-232.

Reference Works

  • Christie, M., Osborne, P. (2007). Opioid Electrophysiology in PAG. In Robert F. Schmidt, William D. Willis (Eds.), Encyclopedia of Pain. (pp. 1532-1534). Germany: Springer.

2014

  • Forrest, S., Osborne, P., Keast, J. (2014). Characterisation of axons expressing the artemin receptor in the female rat urinary bladder: A comparison with other major neuronal populations. The Journal of Comparative Neurology, 522(17), 3900-3927. [More Information]

2013

  • Forrest, S., Osborne, P., Keast, J. (2013). Characterization of bladder sensory neurons in the context of myelination, receptors for pain modulators, and acute responses to bladder inflammation. Frontiers in Neuroscience, 7, 1-12. [More Information]
  • O'Mullane, L., Keast, J., Osborne, P. (2013). Co-Cultures Provide a New Tool to Probe Communication Between Adult Sensory Neurons and Urothelium. The Journal of Urology, 190(2), 737-745. [More Information]

2010

  • Densmore, V., Kalous, A., Keast, J., Osborne, P. (2010). Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. Pain, 151(1), 184-193. [More Information]
  • Keast, J., Forrest, S., Osborne, P. (2010). Sciatic nerve injury in adult rats causes distinct changes in the central projections of sensory neurons expressing different glial cell line-derived neurotrophic factor family receptors. The Journal of Comparative Neurology, 518(15), 3024-3045. [More Information]

2009

  • Hamlin, A., McNally, G., Westbrook, R., Osborne, P. (2009). Induction of Fos proteins in regions of the nucleus accumbens and ventrolateral striatum correlates with catalepsy and stereotypic behaviours induced by morphine. Neuropharmacology, 56(4), 798-807. [More Information]
  • Kalous, A., Osborne, P., Keast, J. (2009). Spinal cord compression injury in adult rats initiates changes in dorsal horn remodeling that may correlate with development of neuropathic pain. The Journal of Comparative Neurology, 513(6), 668-684. [More Information]

2008

  • Xu, S., Cheng, Y., Keast, J., Osborne, P. (2008). 17{beta}-Estradiol activates Estrogen Receptor{beta} signalling and inhibits Transient Receptor Potential Vanilloid Receptor 1 activation by capsaicin in adult rat nociceptor neurons. Endocrinology, 149(11), 5540-5548. [More Information]
  • Chieng, B., Lee, D., Du, Y., Osborne, P., Christie, M., Massottec, D. (2008). Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells. NeuroReport, 19(18), 1793-1796. [More Information]

2007

  • Kalous, A., Osborne, P., Keast, J. (2007). Acute and chronic changes in dorsal horn innervation by primary afferents and descending supraspinal pathways after spinal cord injury. The Journal of Comparative Neurology, 504(3), 238-253. [More Information]
  • Marchant, N., Densmore, V., Osborne, P. (2007). Coexpression of prodynorphin and corticotrophin-releasing hormone in the rat central amygdala: Evidence of two distinct endogenous opioid systems in the lateral division. The Journal of Comparative Neurology, 504(6), 702-715. [More Information]
  • Hamlin, A., McNally, G., Osborne, P. (2007). Induction of c-Fos and zif268 in the nociceptive amygdala parallel abstinence hyperalgesia in rats briefly exposed to morphine. Neuropharmacology, 53(2), 330-343. [More Information]
  • Christie, M., Osborne, P. (2007). Opioid Electrophysiology in PAG. In Robert F. Schmidt, William D. Willis (Eds.), Encyclopedia of Pain. (pp. 1532-1534). Germany: Springer.

2006

  • Chieng, B., Christie, M., Osborne, P. (2006). Characterization of neurons in the rat central nucleus of the amygdala: Cellular physiology, morphology, and opioid sensitivity. The Journal of Comparative Neurology, 497(6), 910-927. [More Information]

2005

  • Buller, K., Hamlin, A., Osborne, P. (2005). Dissection of peripheral and central endogenous opioid modulation of systemic interleukin-1beta responses using c-fos expression in the rat brain. Neuropharmacology, 49(2), 230-242. [More Information]
  • Osborne, P., Halliday, G., Cooper, H., Keast, J. (2005). Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. Neuroscience, 131(3), 671-681. [More Information]

2004

  • Hamlin, A., Buller, K., Day, T., Osborne, P. (2004). Effect Of Naloxone-Precipitated Morphine Withdrawal On C-Fos Expression In Rat Corticotropin-Releasing Hormone Neurons In The Paraventricular Hypothalamus And Extended Amygdala. Neuroscience Letters, 362(1), 39-43.
  • Connor, M., Osborne, P., Christie, M. (2004). Mu-Opioid Receptor Desentization: Is Morphine Different? British Journal of Pharmacology, 143(6), 685-696.
  • Bengtson, C., Lee, D., Osborne, P. (2004). Opposing Electrophysiological Actions Of 5-Ht On Noncholinergic And Cholinergic Neurons In The Rat Ventral Pallidum In Vitro. Journal of Neurophysiology, 92(1), 433-443.

2003

  • Kanjhan, R., Osborne, P., Ouyang, M., Keast, J. (2003). Postnatal maturational changes in rat pelvic autonomic ganglion cells: a mixture of steroid-dependent and -independent effects. Journal of Neurophysiology, 89(1), 315-323.

2002

  • Osborne, P., Vidovic, M., Chieng, B., Hill, C., Christie, M. (2002). Expression of mRNA and functional alpha1-adrenoceptors that supress the GIRK conductance in adult rat locus coeruleus neurons. British Journal of Pharmacology, 13(1), 226-232.

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