Dr Peter Hsu

Staff specialist, Allergy and Immunology, the Children's Hospital at Westmead
Senior Lecturer, Discipline of paediatrics and Child Health, the University of Sydney.

Telephone (02)98453420

Website Honours in Medical Sciences at Westmead

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Research interests

Dr. Peter Hsu is a paediatric allergist and immunologist at the Children's Hospital at Westmead. He leads the Allergy and Immunology Research laboratory at the Kids Research Institute. His research focuses on mechanisms of immune regulation and dysregulation in atopic/allergic disorders and primary immune deficiencies. In particular, his studies aim to explore the role of regulatory immune cell populations in disease pathogenesis and treatment.

Current research students

Project title Research student
Regulatory immune mechanisms in food allergies Catherine LAI

Current projects

- Investigating regulatory T and B cells in children with atopic disorders

- Exploring the mechanism of immune dysregulation in primary immune deficiencies

- Understanding the pathogenesis of Food Protein Induced Enterocolitis Syndrome (FPIES)

- Exploring the immune regulatory mechanisms in oral peanut immunotherapy for the treatment of peanut allergy

Keywords

Immune system diseases; Allergy; Immunology; Autoimmunity; Immune tolerance

Clinical Specialty

Infection and Immunity

Selected grants

2016

  • Kick Start Grants Program 2017 - Hsu; Hsu P; Sydney Medical School/Kickstart Grant.

2015

  • The role of regulatory T cells in common variable immune deficiency caused by PI3K hyperfunction - implications on therapy; Hsu P; Australian Women and Childrens Research Foundation (OZWAC)/Medical Research Project Grant.

2013

  • De novo generation of regulatory T cells for immunotherapy; lessons learnt from human pregnancy; Hsu P; Nepean Medical Research Foundation/Project Grant.

2010

  • The pheno type and functional state of dendritic cells and T lymphocytes in term human decidua in normal pregnancy compomppared to pre-eclampsia; Hsu P; Nepean Medical Research Foundation/Project Grant.
  • HLA-G modulation of antigen producing cells and T helper cells subsets, with specific reference to pregnancy; Hsu P; Australian Women and Childrens Research Foundation (OZWAC)./Medical Research Project Grant.

Selected publications

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Journals

  • Lai, C., Hsu, P., Hu, M., Santner-Nanan, B., Dahlstrom, J., Lee, C., Ajmal, A., Bullman, A., Arbuckle, S., Al Saedi, A., Campbell, D., Nanan, R., et al (2018). IL-2 enhances gut homing potential of human naive regulatory t cells early in life. Journal of Immunology, 200(12), 3970-3980. [More Information]
  • Gay, M., Koleva, P., Slupsky, C., du Toit, E., Eggesbo, M., Johnson, C., Wegienka, G., Shimojo, N., Campbell, D., Hsu, P., et al (2018). Worldwide variation in human milk metabolome: Indicators of breast physiology and maternal lifestyle? Nutrients, 10(9), 1-12. [More Information]
  • Munblit, D., Peroni, D., Boix-Amoros, A., Hsu, P., Van't Land, B., Gay, M., Kolotilina, A., Skevaki, C., Nanan, R., Boyle, R., et al (2017). Human milk and allergic diseases: An unsolved puzzle. Nutrients, 9(8), 1-43. [More Information]
  • Mehr, S., Hsu, P., Campbell, D. (2017). Immunodeficiency in CHARGE syndrome. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 175(4), 516-523. [More Information]
  • Al-Yazidi, L., Marais, B., Hsu, P., Sannappa Venkatraman, S., Kesson, A., Isaacs, D. (2016). A 5-year-old Girl with Chest Wall Mass. Pediatric Infectious Disease Journal, 35(5), 592-599. [More Information]
  • Hsu, P., Campbell, D. (2016). A bug's view of allergic airways disease. Paediatric Respiratory Reviews, 19, 69-74. [More Information]
  • Wong, M., van Ravenswaaij-Arts, C., Munns, C., Hsu, P., Mehr, S., Bocca, G. (2016). Central Adrenal Insufficiency Is Not a Common Feature in CHARGE Syndrome: A Cross-Sectional Study in 2 Cohorts. The Journal of Pediatrics, 176, 150-155. [More Information]
  • Pandit, C., Hsu, P., Van Asperen, P., Mehr, S. (2016). Respiratory manifestations and management in children with Common Variable Immunodeficiency. Paediatric Respiratory Reviews, 19, 56-61. [More Information]
  • Hsu, P., Ma, A., Barnes, E., Wilson, M., Hoefsloot, L., Rinne, T., Munns, C., Williams, G., Wong, M., Mehr, S. (2016). The Immune Phenotype of Patients with CHARGE Syndrome. Journal of Allergy and Clinical Immunology: In Practice, 4(1), 96-103e.2. [More Information]
  • Ma, C., Wong, N., Rao, G., Nguyen, A., Avery, D., Payne, K., Torpy, J., O'Young, P., Deenick, E., Bustamante, J., Elliott, M., Hsu, P., Campbell, D., Adelstein, S., Fulcher, D., et al (2016). Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets. The Journal of Experimental Medicine, 213(8), 1589-1608. [More Information]
  • Hsu, P., Xie, Z., Frith, K., Wong, M., Kakakios, A., Stone, K., Druey, K. (2015). Idiopathic systemic capillary leak syndrome in children. Pediatrics, 135(3), e730-e735. [More Information]
  • Hsu, P., Santner-Nanan, B., Hu, M., Skarratt, K., Lee, C., Stormon, M., Wong, M., Fuller, S., Nanan, R. (2015). IL-10 potentiates differentiation of human induced regulatory T cells via STAT3 and Foxo1. Journal of Immunology, 195(8), 3665-3674. [More Information]
  • Hsu, P., Ma, A., Wilson, M., Williams, G., Curotta, J., Munns, C., Mehr, S. (2014). CHARGE syndrome: A review. Journal of Paediatrics and Child Health, 50(7), 504-511. [More Information]
  • Hsu, P., Santner-Nanan, B., Joung, S., Peek, M., Nanan, R. (2014). Expansion of CD4+HLA-G+ T Cell in Human Pregnancy is Impaired in Pre-Eclampsia. American Journal of Reproductive Immunology, 71(3), 217-228. [More Information]
  • Hsu, P., Nanan, R. (2014). Foetal immune programming: hormones, cytokines, microbes and regulatory T cells. Journal of Reproductive Immunology, 104-105, 2-7. [More Information]
  • Hsu, P., Klimek, J., Nanan, R. (2014). Infantile hypertrophic pyloric stenosis: Does size really matter? Journal of Paediatrics and Child Health, 50(10), 827-828. [More Information]
  • Hsu, P., Nanan, R. (2014). Innate and Adaptive Immune Interactions at the Fetal-Maternal Interface in Healthy Human Pregnancy and Pre-Eclampsia. Frontiers in Immunology, 5, 1-12. [More Information]
  • Neller, M., Nanan, B., Brennan, R., Hsu, P., Joung, S., Nanan, R., Burrows, S., Miles, J. (2014). Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood. Frontiers in Immunology, 5, 1-6. [More Information]
  • Lee, C., Hsu, P., Nanan, B., Nanan, R., Wong, M., Gaskin, K., Leong, R., Murchie, R., Muise, A., Stormon, M. (2014). Novel de novo mutations of the interleukin-10 receptor gene lead to infantile onset inflammatory bowel disease. Journal of Crohn's and Colitis, 8(11), 1551-1556. [More Information]
  • Hsu, P., Mehr, S. (2013). Egg: a frequent trigger of food protein-induced enterocolitis syndrome. Journal of Allergy and Clinical Immunology, 131(1), 241-242. [More Information]
  • Nanan, B., Straubinger, K., Hsu, P., Parnell, G., Tang, B., Xu, B., Makris, A., Hennessy, A., Peek, M., Busch, D., Nanan, R., et al (2013). Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy. Journal of Immunology, 191(1), 145-153. [More Information]
  • Lucey, J., Hsu, P., Ziegler, J. (2013). Tenofovir-related Fanconi's syndrome and osteomalacia in a teenager with HIV. BMJ Case Reports, 2013, 1-3. [More Information]
  • Hsu, P., Nanan, B., Dahlstrom, J., Fadia, M., Chandra, A., Peek, M., Nanan, R. (2012). Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia. American Journal of Pathology, 181(6), 2149-2160. [More Information]
  • Hsu, P., Lam, L., Browne, G. (2010). The pulmonary index score as a clinical assessment tool for acute childhood asthma. Annals of Allergy, Asthma, and Immunology, 105(6), 425-429. [More Information]

2018

  • Lai, C., Hsu, P., Hu, M., Santner-Nanan, B., Dahlstrom, J., Lee, C., Ajmal, A., Bullman, A., Arbuckle, S., Al Saedi, A., Campbell, D., Nanan, R., et al (2018). IL-2 enhances gut homing potential of human naive regulatory t cells early in life. Journal of Immunology, 200(12), 3970-3980. [More Information]
  • Gay, M., Koleva, P., Slupsky, C., du Toit, E., Eggesbo, M., Johnson, C., Wegienka, G., Shimojo, N., Campbell, D., Hsu, P., et al (2018). Worldwide variation in human milk metabolome: Indicators of breast physiology and maternal lifestyle? Nutrients, 10(9), 1-12. [More Information]

2017

  • Munblit, D., Peroni, D., Boix-Amoros, A., Hsu, P., Van't Land, B., Gay, M., Kolotilina, A., Skevaki, C., Nanan, R., Boyle, R., et al (2017). Human milk and allergic diseases: An unsolved puzzle. Nutrients, 9(8), 1-43. [More Information]
  • Mehr, S., Hsu, P., Campbell, D. (2017). Immunodeficiency in CHARGE syndrome. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 175(4), 516-523. [More Information]

2016

  • Al-Yazidi, L., Marais, B., Hsu, P., Sannappa Venkatraman, S., Kesson, A., Isaacs, D. (2016). A 5-year-old Girl with Chest Wall Mass. Pediatric Infectious Disease Journal, 35(5), 592-599. [More Information]
  • Hsu, P., Campbell, D. (2016). A bug's view of allergic airways disease. Paediatric Respiratory Reviews, 19, 69-74. [More Information]
  • Wong, M., van Ravenswaaij-Arts, C., Munns, C., Hsu, P., Mehr, S., Bocca, G. (2016). Central Adrenal Insufficiency Is Not a Common Feature in CHARGE Syndrome: A Cross-Sectional Study in 2 Cohorts. The Journal of Pediatrics, 176, 150-155. [More Information]
  • Pandit, C., Hsu, P., Van Asperen, P., Mehr, S. (2016). Respiratory manifestations and management in children with Common Variable Immunodeficiency. Paediatric Respiratory Reviews, 19, 56-61. [More Information]
  • Hsu, P., Ma, A., Barnes, E., Wilson, M., Hoefsloot, L., Rinne, T., Munns, C., Williams, G., Wong, M., Mehr, S. (2016). The Immune Phenotype of Patients with CHARGE Syndrome. Journal of Allergy and Clinical Immunology: In Practice, 4(1), 96-103e.2. [More Information]
  • Ma, C., Wong, N., Rao, G., Nguyen, A., Avery, D., Payne, K., Torpy, J., O'Young, P., Deenick, E., Bustamante, J., Elliott, M., Hsu, P., Campbell, D., Adelstein, S., Fulcher, D., et al (2016). Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets. The Journal of Experimental Medicine, 213(8), 1589-1608. [More Information]

2015

  • Hsu, P., Xie, Z., Frith, K., Wong, M., Kakakios, A., Stone, K., Druey, K. (2015). Idiopathic systemic capillary leak syndrome in children. Pediatrics, 135(3), e730-e735. [More Information]
  • Hsu, P., Santner-Nanan, B., Hu, M., Skarratt, K., Lee, C., Stormon, M., Wong, M., Fuller, S., Nanan, R. (2015). IL-10 potentiates differentiation of human induced regulatory T cells via STAT3 and Foxo1. Journal of Immunology, 195(8), 3665-3674. [More Information]

2014

  • Hsu, P., Ma, A., Wilson, M., Williams, G., Curotta, J., Munns, C., Mehr, S. (2014). CHARGE syndrome: A review. Journal of Paediatrics and Child Health, 50(7), 504-511. [More Information]
  • Hsu, P., Santner-Nanan, B., Joung, S., Peek, M., Nanan, R. (2014). Expansion of CD4+HLA-G+ T Cell in Human Pregnancy is Impaired in Pre-Eclampsia. American Journal of Reproductive Immunology, 71(3), 217-228. [More Information]
  • Hsu, P., Nanan, R. (2014). Foetal immune programming: hormones, cytokines, microbes and regulatory T cells. Journal of Reproductive Immunology, 104-105, 2-7. [More Information]
  • Hsu, P., Klimek, J., Nanan, R. (2014). Infantile hypertrophic pyloric stenosis: Does size really matter? Journal of Paediatrics and Child Health, 50(10), 827-828. [More Information]
  • Hsu, P., Nanan, R. (2014). Innate and Adaptive Immune Interactions at the Fetal-Maternal Interface in Healthy Human Pregnancy and Pre-Eclampsia. Frontiers in Immunology, 5, 1-12. [More Information]
  • Neller, M., Nanan, B., Brennan, R., Hsu, P., Joung, S., Nanan, R., Burrows, S., Miles, J. (2014). Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood. Frontiers in Immunology, 5, 1-6. [More Information]
  • Lee, C., Hsu, P., Nanan, B., Nanan, R., Wong, M., Gaskin, K., Leong, R., Murchie, R., Muise, A., Stormon, M. (2014). Novel de novo mutations of the interleukin-10 receptor gene lead to infantile onset inflammatory bowel disease. Journal of Crohn's and Colitis, 8(11), 1551-1556. [More Information]

2013

  • Hsu, P., Mehr, S. (2013). Egg: a frequent trigger of food protein-induced enterocolitis syndrome. Journal of Allergy and Clinical Immunology, 131(1), 241-242. [More Information]
  • Nanan, B., Straubinger, K., Hsu, P., Parnell, G., Tang, B., Xu, B., Makris, A., Hennessy, A., Peek, M., Busch, D., Nanan, R., et al (2013). Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy. Journal of Immunology, 191(1), 145-153. [More Information]
  • Lucey, J., Hsu, P., Ziegler, J. (2013). Tenofovir-related Fanconi's syndrome and osteomalacia in a teenager with HIV. BMJ Case Reports, 2013, 1-3. [More Information]

2012

  • Hsu, P., Nanan, B., Dahlstrom, J., Fadia, M., Chandra, A., Peek, M., Nanan, R. (2012). Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia. American Journal of Pathology, 181(6), 2149-2160. [More Information]

2010

  • Hsu, P., Lam, L., Browne, G. (2010). The pulmonary index score as a clinical assessment tool for acute childhood asthma. Annals of Allergy, Asthma, and Immunology, 105(6), 425-429. [More Information]

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