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Professor Philip Hogg

Chair in Translational Cancer Research for Sydney Catalyst
NH&MRC Clinical Trials Centre.

Member of the Charles Perkins Centre


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Current research students

Project title Research student
Redox regulation of platelet integrin function Aster PIJNING
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Selected grants

2018

  • Essential role of ERp5 in thrombosis; Hogg P, Passam F, Zhu C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Redefining the pro-thrombotic mechanism of von Willebrand factor; Hogg P, Flaumenhaft R; National Health and Medical Research Council (NHMRC)/Project Grants.

2017

  • 2016 Australia-Harvard Fellowships- Bruce Furie; Furie B, Furie B, Hogg P; Harvard Club of Australia Foundation/Research Support.
  • ACRF Equipment (DVCR-583); Hogg P; DVC Research/Co-Fund ACRF.

2016

  • Sydney Catalyst - the Translational Cancer Research Centre of central Sydney and regional NSW; Boyer M, Simes R, Hogg P, Butow P, Thomas D, Young J, Vadas M; Cancer Institute NSW/Translational Cancer Research Centre.
  • Wyatt DynaPro NanoStar dynamic light scattering instrument; Mackay J, Matthews J, Sunde M, Ryan R, Hogg P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Regulation of the haemostatic activity of plasma von Willebrand factor; Hogg P; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.

2015

  • The Ghost in the Machine: Understanding how blood coagulation is controlled by protein disulphide bonds; Hogg P; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.

2011

  • Metabolism inhibitors for the treatment of brain and pancreatic cancer; Hogg P; Cancer Council New South Wales/Program Grant.
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Selected publications

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Journals

  • Chiu, J., Hogg, P. (2019). Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation. Journal of Biological Chemistry, 294(8), 2949-2960. [More Information]
  • Hogg, P. (2019). TMX1: A new vascular thiol isomerase. Blood, 133(3), 188-190. [More Information]
  • Butera, D., Passam, F., Ju, L., Cook, K., Woon, H., Aponte-Santamaria, C., Gardiner, E., Davis, A., Murphy, D., Bronowska, A., Jackson, S., Hogg, P., et al (2018). Autoregulation of von Willebrand factor function by a disulfide bond switch. Science Advances, 4(2), 1-12. [More Information]
  • Noy, J., Lu, H., Hogg, P., Yang, J., Stenzel, M. (2018). Direct Polymerization of the Arsenic Drug PENAO to Obtain Nanoparticles with High Thiol-Reactivity and Anti-Cancer Efficiency. Bioconjugate Chemistry, 29(2), 546-558. [More Information]
  • Tsoli, M., Liu, J., Franshaw, L., Shen, H., Cheng, C., Jung, M., Joshi, S., Ehteda, A., Khan, A., Montero-Carcabosso, A., Hogg, P., et al (2018). Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma. Oncotarget, 9(7), 7541-7556. [More Information]
  • Quinlan, R., Hogg, P. (2018). Gamma-Crystallin redox� detox in the lens. Journal of Biological Chemistry, 293(46), 18010-18011. [More Information]
  • Pijning, A., Chiu, J., Yeo, R., Wong, J., Hogg, P. (2018). Identification of allosteric disulfides from labile bonds in X-ray structures. Royal Society Open Science, 5(2), 1-13. [More Information]
  • Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., Hogg, P., et al (2018). Mechano-redox control of integrin de-adhesion. eLife, 7, 1-22. [More Information]
  • Pasalic, L., Wing-Luna, E., Lau, J., Campbell, H., Pennings, G., Lau, E., Connor, D., Liang, H., Muller, D., Kritharides, L., Hogg, P., Chen, V. (2018). Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response. Journal of Thrombosis and Haemostasis, 16(6), 1198-1210. [More Information]
  • Bekendam, R., Iyu, D., Passam, F., Stopa, J., De Ceunynck, K., Muse, O., Bendapudi, P., Garnier, C., Gopal, S., Chiu, J., Hogg, P., et al (2018). Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation. Journal of Thrombosis and Haemostasis, 16(11), 2322-2335. [More Information]
  • Zhou, B., Hogg, P., Grater, F. (2017). One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor. Biophysical Journal, 112(1), 78-86. [More Information]
  • Read, S., O'Connor, K., Suppiah, V., Ahlenstiel, C., Obeid, S., Cook, K., Cunningham, A., Douglas, M., Hogg, P., Booth, D., George, J., Ahlenstiel, G. (2017). Zinc is a potent and specific inhibitor of IFN-(lambda)3 signaling. Nature Communications, 8, 1-15. [More Information]
  • Bekendam, R., Bendapudi, P., Lin, L., Nag, P., Pu, J., Kennedy, D., Feldenzer, A., Chiu, J., Cook, K., Furie, B., Hogg, P., et al (2016). A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications, 7, 1-11. [More Information]
  • Hua, V., Abeynaike, L., Glaros, E., Campbell, H., Pasalic, L., Hogg, P., Chen, V. (2015). Necrotic platelets provide a procoagulant surface during thrombosis. Blood, 126(26), 2852-2862. [More Information]
  • Wilson, P., Anastasaki, A., Owen, M., Kempe, K., Haddleton, D., Mann, S., Johnston, A., Quinn, J., Whittaker, M., Hogg, P., et al (2015). Organic arsenicals as efficient and highly specific linkers for protein/peptide-polymer conjugation. Journal of the American Chemical Society, 137(12), 4215-4222. [More Information]
  • Chiu, J., Passam, F., Butera, D., Hogg, P. (2015). Protein Disulfide Isomerase in Thrombosis. Seminars in Thrombosis and Hemostasis, 41(7), 765-773. [More Information]
  • Butera, D., Wind, T., Lay, A., Beck, J., Castellino, F., Hogg, P. (2014). Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. Journal of Biological Chemistry, 289(5), 2992-3000. [More Information]
  • Butera, D., Cook, K., Chiu, J., Wong, J., Hogg, P. (2014). Control of blood proteins by functional disulfide bonds. Blood, 123(13), 2000-2007. [More Information]
  • Ramsay, E., Decollogne, S., Joshi, S., Corti, A., Apte, M., Pompella, A., Hogg, P., Dilda, P. (2014). Employing Pancreatic Tumor y-Glutamyltransferase for Therapeutic Delivery. Molecular Pharmaceutics, 11(5), 1500-1511. [More Information]
  • Chiu, J., Wong, J., Gerometta, M., Hogg, P. (2014). Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C. Biochemistry, 53(1), 7-9. [More Information]
  • Chiu, J., Wong, J., Hogg, P. (2014). Redox Regulation of Methionine Aminopeptidase 2 Activity. Journal of Biological Chemistry, 289(21), 15035-15043. [More Information]
  • Cook, K., McNeil, H., Hogg, P. (2013). Allosteric control of betaII-tryptase by a redox active disulfide bond. Journal of Biological Chemistry, 288(48), 34920-34929. [More Information]
  • Chen, V., Hogg, P. (2013). Encryption and decryption of tissue factor. Journal of Thrombosis and Haemostasis, 11(Suppl 1), 277-284. [More Information]
  • Xie, B., Park, D., Van Beek, E., Blankevoort, V., Orabi, Y., Que, I., Kaijzel, E., Chan, A., Hogg, P., Lowik, C. (2013). Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator. Cell Death and Disease, 4, 1-8. [More Information]
  • Cook, K., Hogg, P. (2013). Post-translational control of protein function by disulfide bond cleavage. Antioxidants & Redox Signaling, 18(15), 1987-2015. [More Information]
  • Hogg, P. (2013). Targeting allosteric disulphide bonds in cancer. Nature Reviews. Cancer, 13(6), 425-431. [More Information]
  • Ng, J., Chiu, J., Hogg, P., Wong, J. (2013). Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. Biochemical and Biophysical Research Communications, 440(1), 37-42. [More Information]
  • Park, D., Chiu, J., Perrone, G., Dilda, P., Hogg, P. (2012). The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell International, 12(1), 1-6. [More Information]
  • Wong, J., Ho, S., Hogg, P. (2011). Disulfide bond acquisition through eukaryotic protein evolution. Molecular Biology and Evolution, 28(1), 327-334. [More Information]
  • Ganderton, T., Wong, J., Schroeder, C., Hogg, P. (2011). Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain. Blood, 118(19), 5312-5318. [More Information]
  • Park, D., Don, A., Massamiri, T., Karwa, A., Warner, B., MacDonald, J., Hemenway, C., Naik, A., Kuan, K., Hogg, P., et al (2011). Noninvasive imaging of cell death using an Hsp90 ligand. Journal of the American Chemical Society, 133(9), 2832-2835. [More Information]
  • Scott, A., O'Dea, K., O'Callaghan, D., Williams, L., Dokpesi, J., Tatton, L., Handy, J., Hogg, P., Takata, M. (2011). Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor alpha-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. Journal of Biological Chemistry, 286(41), 35466-35476. [More Information]
  • Passam, F., Rahgozar, S., Qi, M., Raftery, M., Wong, J., Tanaka, K., Ioannou, Y., Zhang, J., Gemmell, R., Hogg, P., et al (2010). Beta 2 glycoprotein I is a substrate of thiol oxidoreductases. Blood, 116(11), 1995-1997. [More Information]
  • Wong, J., Ho, S., Hogg, P. (2010). Disulfide bond acquisition through eukaryotic protein evolution. Molecular Biology and Evolution, 28(1), 327-334. [More Information]
  • Ioannou, Y., Zhang, J., Passam, F., Rahgozar, S., Qi, J., Giannakopoulos, B., Qi, M., Yu, P., Yu, D., Hogg, P., et al (2010). Naturally occurring free thiols within {beta}2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells and regulation of oxidative stress induced cell injury. Blood, 116(11), 1961-1970. [More Information]
  • Matthias, L., Azimi, I., Tabrett, C., Hogg, P. (2010). Reduced monomeric CD4 is the preferred receptor for HIV. Journal of Biological Chemistry, 285(52), 40793-40799. [More Information]
  • Azimi, I., Matthias, L., Center, R., Wong, J., Hogg, P. (2010). The disulfide bond that constrains the HIV-1 gp120 V3 domain is cleaved by thioredoxin. Journal of Biological Chemistry, 285(51), 40072-40080. [More Information]
  • Dilda, P., Decollogne, S., Weerakoon, L., Norris, M., Haber, M., Allen, J., Hogg, P. (2009). Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol. Journal of Medicinal Chemistry, 52(20), 6209-6216. [More Information]

2019

  • Chiu, J., Hogg, P. (2019). Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation. Journal of Biological Chemistry, 294(8), 2949-2960. [More Information]
  • Hogg, P. (2019). TMX1: A new vascular thiol isomerase. Blood, 133(3), 188-190. [More Information]

2018

  • Butera, D., Passam, F., Ju, L., Cook, K., Woon, H., Aponte-Santamaria, C., Gardiner, E., Davis, A., Murphy, D., Bronowska, A., Jackson, S., Hogg, P., et al (2018). Autoregulation of von Willebrand factor function by a disulfide bond switch. Science Advances, 4(2), 1-12. [More Information]
  • Noy, J., Lu, H., Hogg, P., Yang, J., Stenzel, M. (2018). Direct Polymerization of the Arsenic Drug PENAO to Obtain Nanoparticles with High Thiol-Reactivity and Anti-Cancer Efficiency. Bioconjugate Chemistry, 29(2), 546-558. [More Information]
  • Tsoli, M., Liu, J., Franshaw, L., Shen, H., Cheng, C., Jung, M., Joshi, S., Ehteda, A., Khan, A., Montero-Carcabosso, A., Hogg, P., et al (2018). Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma. Oncotarget, 9(7), 7541-7556. [More Information]
  • Quinlan, R., Hogg, P. (2018). Gamma-Crystallin redox� detox in the lens. Journal of Biological Chemistry, 293(46), 18010-18011. [More Information]
  • Pijning, A., Chiu, J., Yeo, R., Wong, J., Hogg, P. (2018). Identification of allosteric disulfides from labile bonds in X-ray structures. Royal Society Open Science, 5(2), 1-13. [More Information]
  • Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., Hogg, P., et al (2018). Mechano-redox control of integrin de-adhesion. eLife, 7, 1-22. [More Information]
  • Pasalic, L., Wing-Luna, E., Lau, J., Campbell, H., Pennings, G., Lau, E., Connor, D., Liang, H., Muller, D., Kritharides, L., Hogg, P., Chen, V. (2018). Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response. Journal of Thrombosis and Haemostasis, 16(6), 1198-1210. [More Information]
  • Bekendam, R., Iyu, D., Passam, F., Stopa, J., De Ceunynck, K., Muse, O., Bendapudi, P., Garnier, C., Gopal, S., Chiu, J., Hogg, P., et al (2018). Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation. Journal of Thrombosis and Haemostasis, 16(11), 2322-2335. [More Information]

2017

  • Zhou, B., Hogg, P., Grater, F. (2017). One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor. Biophysical Journal, 112(1), 78-86. [More Information]
  • Read, S., O'Connor, K., Suppiah, V., Ahlenstiel, C., Obeid, S., Cook, K., Cunningham, A., Douglas, M., Hogg, P., Booth, D., George, J., Ahlenstiel, G. (2017). Zinc is a potent and specific inhibitor of IFN-(lambda)3 signaling. Nature Communications, 8, 1-15. [More Information]

2016

  • Bekendam, R., Bendapudi, P., Lin, L., Nag, P., Pu, J., Kennedy, D., Feldenzer, A., Chiu, J., Cook, K., Furie, B., Hogg, P., et al (2016). A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications, 7, 1-11. [More Information]

2015

  • Hua, V., Abeynaike, L., Glaros, E., Campbell, H., Pasalic, L., Hogg, P., Chen, V. (2015). Necrotic platelets provide a procoagulant surface during thrombosis. Blood, 126(26), 2852-2862. [More Information]
  • Wilson, P., Anastasaki, A., Owen, M., Kempe, K., Haddleton, D., Mann, S., Johnston, A., Quinn, J., Whittaker, M., Hogg, P., et al (2015). Organic arsenicals as efficient and highly specific linkers for protein/peptide-polymer conjugation. Journal of the American Chemical Society, 137(12), 4215-4222. [More Information]
  • Chiu, J., Passam, F., Butera, D., Hogg, P. (2015). Protein Disulfide Isomerase in Thrombosis. Seminars in Thrombosis and Hemostasis, 41(7), 765-773. [More Information]

2014

  • Butera, D., Wind, T., Lay, A., Beck, J., Castellino, F., Hogg, P. (2014). Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. Journal of Biological Chemistry, 289(5), 2992-3000. [More Information]
  • Butera, D., Cook, K., Chiu, J., Wong, J., Hogg, P. (2014). Control of blood proteins by functional disulfide bonds. Blood, 123(13), 2000-2007. [More Information]
  • Ramsay, E., Decollogne, S., Joshi, S., Corti, A., Apte, M., Pompella, A., Hogg, P., Dilda, P. (2014). Employing Pancreatic Tumor y-Glutamyltransferase for Therapeutic Delivery. Molecular Pharmaceutics, 11(5), 1500-1511. [More Information]
  • Chiu, J., Wong, J., Gerometta, M., Hogg, P. (2014). Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C. Biochemistry, 53(1), 7-9. [More Information]
  • Chiu, J., Wong, J., Hogg, P. (2014). Redox Regulation of Methionine Aminopeptidase 2 Activity. Journal of Biological Chemistry, 289(21), 15035-15043. [More Information]

2013

  • Cook, K., McNeil, H., Hogg, P. (2013). Allosteric control of betaII-tryptase by a redox active disulfide bond. Journal of Biological Chemistry, 288(48), 34920-34929. [More Information]
  • Chen, V., Hogg, P. (2013). Encryption and decryption of tissue factor. Journal of Thrombosis and Haemostasis, 11(Suppl 1), 277-284. [More Information]
  • Xie, B., Park, D., Van Beek, E., Blankevoort, V., Orabi, Y., Que, I., Kaijzel, E., Chan, A., Hogg, P., Lowik, C. (2013). Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator. Cell Death and Disease, 4, 1-8. [More Information]
  • Cook, K., Hogg, P. (2013). Post-translational control of protein function by disulfide bond cleavage. Antioxidants & Redox Signaling, 18(15), 1987-2015. [More Information]
  • Hogg, P. (2013). Targeting allosteric disulphide bonds in cancer. Nature Reviews. Cancer, 13(6), 425-431. [More Information]
  • Ng, J., Chiu, J., Hogg, P., Wong, J. (2013). Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. Biochemical and Biophysical Research Communications, 440(1), 37-42. [More Information]

2012

  • Park, D., Chiu, J., Perrone, G., Dilda, P., Hogg, P. (2012). The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell International, 12(1), 1-6. [More Information]

2011

  • Wong, J., Ho, S., Hogg, P. (2011). Disulfide bond acquisition through eukaryotic protein evolution. Molecular Biology and Evolution, 28(1), 327-334. [More Information]
  • Ganderton, T., Wong, J., Schroeder, C., Hogg, P. (2011). Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain. Blood, 118(19), 5312-5318. [More Information]
  • Park, D., Don, A., Massamiri, T., Karwa, A., Warner, B., MacDonald, J., Hemenway, C., Naik, A., Kuan, K., Hogg, P., et al (2011). Noninvasive imaging of cell death using an Hsp90 ligand. Journal of the American Chemical Society, 133(9), 2832-2835. [More Information]
  • Scott, A., O'Dea, K., O'Callaghan, D., Williams, L., Dokpesi, J., Tatton, L., Handy, J., Hogg, P., Takata, M. (2011). Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor alpha-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. Journal of Biological Chemistry, 286(41), 35466-35476. [More Information]

2010

  • Passam, F., Rahgozar, S., Qi, M., Raftery, M., Wong, J., Tanaka, K., Ioannou, Y., Zhang, J., Gemmell, R., Hogg, P., et al (2010). Beta 2 glycoprotein I is a substrate of thiol oxidoreductases. Blood, 116(11), 1995-1997. [More Information]
  • Wong, J., Ho, S., Hogg, P. (2010). Disulfide bond acquisition through eukaryotic protein evolution. Molecular Biology and Evolution, 28(1), 327-334. [More Information]
  • Ioannou, Y., Zhang, J., Passam, F., Rahgozar, S., Qi, J., Giannakopoulos, B., Qi, M., Yu, P., Yu, D., Hogg, P., et al (2010). Naturally occurring free thiols within {beta}2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells and regulation of oxidative stress induced cell injury. Blood, 116(11), 1961-1970. [More Information]
  • Matthias, L., Azimi, I., Tabrett, C., Hogg, P. (2010). Reduced monomeric CD4 is the preferred receptor for HIV. Journal of Biological Chemistry, 285(52), 40793-40799. [More Information]
  • Azimi, I., Matthias, L., Center, R., Wong, J., Hogg, P. (2010). The disulfide bond that constrains the HIV-1 gp120 V3 domain is cleaved by thioredoxin. Journal of Biological Chemistry, 285(51), 40072-40080. [More Information]

2009

  • Dilda, P., Decollogne, S., Weerakoon, L., Norris, M., Haber, M., Allen, J., Hogg, P. (2009). Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol. Journal of Medicinal Chemistry, 52(20), 6209-6216. [More Information]
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