Professor Philip Hogg

Chair in Translational Cancer Research for Sydney Catalyst
NH&MRC Clinical Trials Centre.

Member of the Charles Perkins Centre


Map

Current research students

Project title Research student
Characterisation and targeting of glucose metabolism in brain tumours. Reichelle YEO

Selected grants

2018

  • Redefining the pro-thrombotic mechanism of von Willebrand factor; Hogg P, Flaumenhaft R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Essential role of ERp5 in thrombosis; Hogg P, Passam F, Zhu C; National Health and Medical Research Council (NHMRC)/Project Grants.

2017

  • 2016 Australia-Harvard Fellowships- Bruce Furie; Furie B, Furie B, Hogg P; Harvard Club of Australia Foundation/Research Support.
  • ACRF Equipment (DVCR-583); Hogg P; DVC Research/Co-Fund ACRF.

2016

  • Sydney Catalyst - the Translational Cancer Research Centre of central Sydney and regional NSW; Boyer M, Simes R, Hogg P, Butow P, Thomas D, Young J, Vadas M; Cancer Institute New South Wales/Translational Cancer Research Centre.
  • Regulation of the haemostatic activity of plasma von Willebrand factor; Hogg P; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • Wyatt DynaPro NanoStar dynamic light scattering instrument; Mackay J, Matthews J, Sunde M, Ryan R, Hogg P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2015

  • The Ghost in the Machine: Understanding how blood coagulation is controlled by protein disulphide bonds; Hogg P; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.

2011

  • Metabolism inhibitors for the treatment of brain and pancreatic cancer; Hogg P; Cancer Council New South Wales/Program Grant.

Selected publications

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Journals

  • Butera, D., Passam, F., Ju, L., Cook, K., Woon, H., Aponte-Santamaria, C., Gardiner, E., Davis, A., Murphy, D., Bronowska, A., Jackson, S., Hogg, P., et al (2018). Autoregulation of von Willebrand factor function by a disulfide bond switch. Science Advances, 4(2), 1-12. [More Information]
  • Noy, J., Lu, H., Hogg, P., Yang, J., Stenzel, M. (2018). Direct Polymerization of the Arsenic Drug PENAO to Obtain Nanoparticles with High Thiol-Reactivity and Anti-Cancer Efficiency. Bioconjugate Chemistry, 29(2), 546-558. [More Information]
  • Tsoli, M., Liu, J., Franshaw, L., Shen, H., Cheng, C., Jung, M., Joshi, S., Ehteda, A., Khan, A., Montero-Carcabosso, A., Hogg, P., et al (2018). Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma. Oncotarget, 9(7), 7541-7556. [More Information]
  • Pijning, A., Chiu, J., Yeo, R., Wong, J., Hogg, P. (2018). Identification of allosteric disulfides from labile bonds in X-ray structures. Royal Society Open Science, 5(2), 1-13. [More Information]
  • Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., Hogg, P., et al (2018). Mechano-redox control of integrin de-adhesion. eLife, 7, 1-22. [More Information]
  • Pasalic, L., Wing-Luna, E., Lau, J., Campbell, H., Pennings, G., Lau, E., Connor, D., Liang, H., Muller, D., Kritharides, L., Hogg, P., Chen, V. (2018). Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response. Journal of Thrombosis and Haemostasis, 16(6), 1198-1210. [More Information]
  • Zhou, B., Hogg, P., Grater, F. (2017). One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor. Biophysical Journal, 112(1), 78-86. [More Information]
  • Read, S., O'Connor, K., Suppiah, V., Ahlenstiel, C., Obeid, S., Cook, K., Cunningham, A., Douglas, M., Hogg, P., Booth, D., George, J., Ahlenstiel, G. (2017). Zinc is a potent and specific inhibitor of IFN-(lambda)3 signaling. Nature Communications, 8, 1-15. [More Information]
  • Bekendam, R., Bendapudi, P., Lin, L., Nag, P., Pu, J., Kennedy, D., Feldenzer, A., Chiu, J., Cook, K., Furie, B., Hogg, P., et al (2016). A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications, 7, 1-11. [More Information]
  • Hua, V., Abeynaike, L., Glaros, E., Campbell, H., Pasalic, L., Hogg, P., Chen, V. (2015). Necrotic platelets provide a procoagulant surface during thrombosis. Blood, 126(26), 2852-2862. [More Information]
  • Wilson, P., Anastasaki, A., Owen, M., Kempe, K., Haddleton, D., Mann, S., Johnston, A., Quinn, J., Whittaker, M., Hogg, P., et al (2015). Organic arsenicals as efficient and highly specific linkers for protein/peptide-polymer conjugation. Journal of the American Chemical Society, 137(12), 4215-4222. [More Information]
  • Chiu, J., Passam, F., Butera, D., Hogg, P. (2015). Protein Disulfide Isomerase in Thrombosis. Seminars in Thrombosis and Hemostasis, 41(7), 765-773. [More Information]
  • Butera, D., Wind, T., Lay, A., Beck, J., Castellino, F., Hogg, P. (2014). Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. Journal of Biological Chemistry, 289(5), 2992-3000. [More Information]
  • Butera, D., Cook, K., Chiu, J., Wong, J., Hogg, P. (2014). Control of blood proteins by functional disulfide bonds. Blood, 123(13), 2000-2007. [More Information]
  • Ramsay, E., Decollogne, S., Joshi, S., Corti, A., Apte, M., Pompella, A., Hogg, P., Dilda, P. (2014). Employing Pancreatic Tumor y-Glutamyltransferase for Therapeutic Delivery. Molecular Pharmaceutics, 11(5), 1500-1511. [More Information]
  • Chiu, J., Wong, J., Gerometta, M., Hogg, P. (2014). Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C. Biochemistry, 53(1), 7-9. [More Information]
  • Chiu, J., Wong, J., Hogg, P. (2014). Redox Regulation of Methionine Aminopeptidase 2 Activity. Journal of Biological Chemistry, 289(21), 15035-15043. [More Information]
  • Cook, K., McNeil, H., Hogg, P. (2013). Allosteric control of betaII-tryptase by a redox active disulfide bond. Journal of Biological Chemistry, 288(48), 34920-34929. [More Information]
  • Chen, V., Hogg, P. (2013). Encryption and decryption of tissue factor. Journal of Thrombosis and Haemostasis, 11(Suppl 1), 277-284. [More Information]
  • Xie, B., Park, D., Van Beek, E., Blankevoort, V., Orabi, Y., Que, I., Kaijzel, E., Chan, A., Hogg, P., Lowik, C. (2013). Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator. Cell Death and Disease, 4, 1-8. [More Information]
  • Cook, K., Hogg, P. (2013). Post-translational control of protein function by disulfide bond cleavage. Antioxidants & Redox Signaling, 18(15), 1987-2015. [More Information]
  • Hogg, P. (2013). Targeting allosteric disulphide bonds in cancer. Nature Reviews. Cancer, 13(6), 425-431. [More Information]
  • Ng, J., Chiu, J., Hogg, P., Wong, J. (2013). Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. Biochemical and Biophysical Research Communications, 440(1), 37-42. [More Information]
  • Park, D., Chiu, J., Perrone, G., Dilda, P., Hogg, P. (2012). The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell International, 12(1), 1-6. [More Information]
  • Wong, J., Ho, S., Hogg, P. (2011). Disulfide bond acquisition through eukaryotic protein evolution. Molecular Biology and Evolution, 28(1), 327-334. [More Information]
  • Ganderton, T., Wong, J., Schroeder, C., Hogg, P. (2011). Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain. Blood, 118(19), 5312-5318. [More Information]
  • Park, D., Don, A., Massamiri, T., Karwa, A., Warner, B., MacDonald, J., Hemenway, C., Naik, A., Kuan, K., Hogg, P., et al (2011). Noninvasive imaging of cell death using an Hsp90 ligand. Journal of the American Chemical Society, 133(9), 2832-2835. [More Information]
  • Scott, A., O'Dea, K., O'Callaghan, D., Williams, L., Dokpesi, J., Tatton, L., Handy, J., Hogg, P., Takata, M. (2011). Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor alpha-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. Journal of Biological Chemistry, 286(41), 35466-35476. [More Information]
  • Passam, F., Rahgozar, S., Qi, M., Raftery, M., Wong, J., Tanaka, K., Ioannou, Y., Zhang, J., Gemmell, R., Hogg, P., et al (2010). Beta 2 glycoprotein I is a substrate of thiol oxidoreductases. Blood, 116(11), 1995-1997. [More Information]
  • Wong, J., Ho, S., Hogg, P. (2010). Disulfide bond acquisition through eukaryotic protein evolution. Molecular Biology and Evolution, 28(1), 327-334. [More Information]
  • Ioannou, Y., Zhang, J., Passam, F., Rahgozar, S., Qi, J., Giannakopoulos, B., Qi, M., Yu, P., Yu, D., Hogg, P., et al (2010). Naturally occurring free thiols within {beta}2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells and regulation of oxidative stress induced cell injury. Artificial Cells, Blood Substitutes, and Biotechnology, 116(11), 1961-1970. [More Information]
  • Matthias, L., Azimi, I., Tabrett, C., Hogg, P. (2010). Reduced monomeric CD4 is the preferred receptor for HIV. Journal of Biological Chemistry, 285(52), 40793-40799. [More Information]
  • Azimi, I., Matthias, L., Center, R., Wong, J., Hogg, P. (2010). The disulfide bond that constrains the HIV-1 gp120 V3 domain is cleaved by thioredoxin. Journal of Biological Chemistry, 285(51), 40072-40080. [More Information]
  • Dilda, P., Decollogne, S., Weerakoon, L., Norris, M., Haber, M., Allen, J., Hogg, P. (2009). Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol. Journal of Medicinal Chemistry, 52(20), 6209-6216. [More Information]

2018

  • Butera, D., Passam, F., Ju, L., Cook, K., Woon, H., Aponte-Santamaria, C., Gardiner, E., Davis, A., Murphy, D., Bronowska, A., Jackson, S., Hogg, P., et al (2018). Autoregulation of von Willebrand factor function by a disulfide bond switch. Science Advances, 4(2), 1-12. [More Information]
  • Noy, J., Lu, H., Hogg, P., Yang, J., Stenzel, M. (2018). Direct Polymerization of the Arsenic Drug PENAO to Obtain Nanoparticles with High Thiol-Reactivity and Anti-Cancer Efficiency. Bioconjugate Chemistry, 29(2), 546-558. [More Information]
  • Tsoli, M., Liu, J., Franshaw, L., Shen, H., Cheng, C., Jung, M., Joshi, S., Ehteda, A., Khan, A., Montero-Carcabosso, A., Hogg, P., et al (2018). Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma. Oncotarget, 9(7), 7541-7556. [More Information]
  • Pijning, A., Chiu, J., Yeo, R., Wong, J., Hogg, P. (2018). Identification of allosteric disulfides from labile bonds in X-ray structures. Royal Society Open Science, 5(2), 1-13. [More Information]
  • Passam, F., Chiu, J., Ju, L., Pijning, A., Jahan, Z., Mor-Cohen, R., Yeheskel, A., Kolsek, K., Tharichen, L., Aponte-Santamaria, C., Hogg, P., et al (2018). Mechano-redox control of integrin de-adhesion. eLife, 7, 1-22. [More Information]
  • Pasalic, L., Wing-Luna, E., Lau, J., Campbell, H., Pennings, G., Lau, E., Connor, D., Liang, H., Muller, D., Kritharides, L., Hogg, P., Chen, V. (2018). Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response. Journal of Thrombosis and Haemostasis, 16(6), 1198-1210. [More Information]

2017

  • Zhou, B., Hogg, P., Grater, F. (2017). One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor. Biophysical Journal, 112(1), 78-86. [More Information]
  • Read, S., O'Connor, K., Suppiah, V., Ahlenstiel, C., Obeid, S., Cook, K., Cunningham, A., Douglas, M., Hogg, P., Booth, D., George, J., Ahlenstiel, G. (2017). Zinc is a potent and specific inhibitor of IFN-(lambda)3 signaling. Nature Communications, 8, 1-15. [More Information]

2016

  • Bekendam, R., Bendapudi, P., Lin, L., Nag, P., Pu, J., Kennedy, D., Feldenzer, A., Chiu, J., Cook, K., Furie, B., Hogg, P., et al (2016). A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications, 7, 1-11. [More Information]

2015

  • Hua, V., Abeynaike, L., Glaros, E., Campbell, H., Pasalic, L., Hogg, P., Chen, V. (2015). Necrotic platelets provide a procoagulant surface during thrombosis. Blood, 126(26), 2852-2862. [More Information]
  • Wilson, P., Anastasaki, A., Owen, M., Kempe, K., Haddleton, D., Mann, S., Johnston, A., Quinn, J., Whittaker, M., Hogg, P., et al (2015). Organic arsenicals as efficient and highly specific linkers for protein/peptide-polymer conjugation. Journal of the American Chemical Society, 137(12), 4215-4222. [More Information]
  • Chiu, J., Passam, F., Butera, D., Hogg, P. (2015). Protein Disulfide Isomerase in Thrombosis. Seminars in Thrombosis and Hemostasis, 41(7), 765-773. [More Information]

2014

  • Butera, D., Wind, T., Lay, A., Beck, J., Castellino, F., Hogg, P. (2014). Characterization of a reduced form of plasma plasminogen as the precursor for angiostatin formation. Journal of Biological Chemistry, 289(5), 2992-3000. [More Information]
  • Butera, D., Cook, K., Chiu, J., Wong, J., Hogg, P. (2014). Control of blood proteins by functional disulfide bonds. Blood, 123(13), 2000-2007. [More Information]
  • Ramsay, E., Decollogne, S., Joshi, S., Corti, A., Apte, M., Pompella, A., Hogg, P., Dilda, P. (2014). Employing Pancreatic Tumor y-Glutamyltransferase for Therapeutic Delivery. Molecular Pharmaceutics, 11(5), 1500-1511. [More Information]
  • Chiu, J., Wong, J., Gerometta, M., Hogg, P. (2014). Mechanism of dimerization of a recombinant mature vascular endothelial growth factor C. Biochemistry, 53(1), 7-9. [More Information]
  • Chiu, J., Wong, J., Hogg, P. (2014). Redox Regulation of Methionine Aminopeptidase 2 Activity. Journal of Biological Chemistry, 289(21), 15035-15043. [More Information]

2013

  • Cook, K., McNeil, H., Hogg, P. (2013). Allosteric control of betaII-tryptase by a redox active disulfide bond. Journal of Biological Chemistry, 288(48), 34920-34929. [More Information]
  • Chen, V., Hogg, P. (2013). Encryption and decryption of tissue factor. Journal of Thrombosis and Haemostasis, 11(Suppl 1), 277-284. [More Information]
  • Xie, B., Park, D., Van Beek, E., Blankevoort, V., Orabi, Y., Que, I., Kaijzel, E., Chan, A., Hogg, P., Lowik, C. (2013). Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator. Cell Death and Disease, 4, 1-8. [More Information]
  • Cook, K., Hogg, P. (2013). Post-translational control of protein function by disulfide bond cleavage. Antioxidants & Redox Signaling, 18(15), 1987-2015. [More Information]
  • Hogg, P. (2013). Targeting allosteric disulphide bonds in cancer. Nature Reviews. Cancer, 13(6), 425-431. [More Information]
  • Ng, J., Chiu, J., Hogg, P., Wong, J. (2013). Tyrosine nitration moderates the peptidase activity of human methionyl aminopeptidase 2. Biochemical and Biophysical Research Communications, 440(1), 37-42. [More Information]

2012

  • Park, D., Chiu, J., Perrone, G., Dilda, P., Hogg, P. (2012). The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase. Cancer Cell International, 12(1), 1-6. [More Information]

2011

  • Wong, J., Ho, S., Hogg, P. (2011). Disulfide bond acquisition through eukaryotic protein evolution. Molecular Biology and Evolution, 28(1), 327-334. [More Information]
  • Ganderton, T., Wong, J., Schroeder, C., Hogg, P. (2011). Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain. Blood, 118(19), 5312-5318. [More Information]
  • Park, D., Don, A., Massamiri, T., Karwa, A., Warner, B., MacDonald, J., Hemenway, C., Naik, A., Kuan, K., Hogg, P., et al (2011). Noninvasive imaging of cell death using an Hsp90 ligand. Journal of the American Chemical Society, 133(9), 2832-2835. [More Information]
  • Scott, A., O'Dea, K., O'Callaghan, D., Williams, L., Dokpesi, J., Tatton, L., Handy, J., Hogg, P., Takata, M. (2011). Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor alpha-converting enzyme (TACE/ADAM-17) activation in primary human monocytes. Journal of Biological Chemistry, 286(41), 35466-35476. [More Information]

2010

  • Passam, F., Rahgozar, S., Qi, M., Raftery, M., Wong, J., Tanaka, K., Ioannou, Y., Zhang, J., Gemmell, R., Hogg, P., et al (2010). Beta 2 glycoprotein I is a substrate of thiol oxidoreductases. Blood, 116(11), 1995-1997. [More Information]
  • Wong, J., Ho, S., Hogg, P. (2010). Disulfide bond acquisition through eukaryotic protein evolution. Molecular Biology and Evolution, 28(1), 327-334. [More Information]
  • Ioannou, Y., Zhang, J., Passam, F., Rahgozar, S., Qi, J., Giannakopoulos, B., Qi, M., Yu, P., Yu, D., Hogg, P., et al (2010). Naturally occurring free thiols within {beta}2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells and regulation of oxidative stress induced cell injury. Artificial Cells, Blood Substitutes, and Biotechnology, 116(11), 1961-1970. [More Information]
  • Matthias, L., Azimi, I., Tabrett, C., Hogg, P. (2010). Reduced monomeric CD4 is the preferred receptor for HIV. Journal of Biological Chemistry, 285(52), 40793-40799. [More Information]
  • Azimi, I., Matthias, L., Center, R., Wong, J., Hogg, P. (2010). The disulfide bond that constrains the HIV-1 gp120 V3 domain is cleaved by thioredoxin. Journal of Biological Chemistry, 285(51), 40072-40080. [More Information]

2009

  • Dilda, P., Decollogne, S., Weerakoon, L., Norris, M., Haber, M., Allen, J., Hogg, P. (2009). Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol. Journal of Medicinal Chemistry, 52(20), 6209-6216. [More Information]

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