Professor Philip O'Connell

Clinical Professor
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 7388
Fax +61 2 9633 9351

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Selected grants

2013

  • Building sustainable collaborations in diabetes and islet transplantation research and practice in Sydney and Shanghai; Hu M, Alexander S, Freckelton L, Hawthorne W, O'Connell P, Wang W, Ning G, Li X, Gu W, Dai J; DVC International/IPDF Grant.
  • Pathogenesis-based treatment of type 1 diabetes; Harrison L, Lew A, O'Connell P, Kay T, Morahan G, Thomas H; National Health and Medical Research Council (NHMRC)/Program Grants.

2012

  • Small Rodent Airlaw Caging System; George J, O'Connell P, Cunningham A, Hawthorne W, Little D, Djordjevic J, Harris D, Hebbard L, Liddle C, Fletcher J; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Practitioner Fellowship Level 2; O'Connell P; National Health and Medical Research Council (NHMRC)/Career Awards: Practitioner Fellowships.

2008

  • Prevention and Cure of Type 1 Diabetes; O'Connell P; National Health and Medical Research Council (NHMRC)/Program Grants.

2007

  • The Genomics of Chronic Allograft Rejection; O'Connell P, Murphy B; National Institutes of Health (USA)/Research Support.
  • A pre-clinical surgical model for clinical islet transplantation; O'Connell P; University of Sydney/Bridging Support.

2006

  • The Development of a National Centre for Clinical Islet Transplantation; Russ G, Wilson M, Dado M, Kay T, O'Connell P, George J, Hawthorne W; Juvenile Diabetes Research Foundation/Project Support.

2005

  • Strategies to prevent islet transplant-induced portal vein thrombosis.; O'Connell P, Harris A; Juvenile Diabetes Research Foundation International (JDRF)/Regular Research Grants.

2003

  • Centre of clinical research excellence in renal medicine; Walker R, Atkins R, Craig J, Chadban S, Irwig L, Harris D, O'Connell P, Walker R, Chadban S, Atkins R, Irwig L; National Health and Medical Research Council (NHMRC)/Centre of Clinical Research Excellence.
  • Non immunological barriers to successful treatment of diabetes by xenotransplantation?; Hawthorne W, Allen R, O'Connell P, Chapman J, Moran C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role and function of macrophages in cellular xenograft rejection; O'Connell P, Yi S; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • A preclinical model of pig islet xenotransplantation as treatment for Type 1 diabetes; O'Connell P, Moran C, d'Apice A, Lew M, Nottle M; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • The role of T-cell apoptosis in transplantation tolerance; O'Connell P; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Donaghue, K., Keech, A., Craig, M., O'Connell, P. (2012). A 'cure' for diabetes and its complications. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 401-420). Sydney, Australia: Sydney University Press.

Journals

  • Huang, J., Zheng, S., Liu, Y., Wang, H., Chapman, J., O'Connell, P., Millis, M., Fung, J., Delmonico, F. (2014). China organ donation and transplantation update: the Hangzhou Resolution. Hepatobiliary & Pancreatic Diseases International, 13(2), 122-124. [More Information]
  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation, 97(1), 30-38. [More Information]
  • Chen, Y., Stewart, J., Gunthart, M., Hawthorne, W., Salvaris, E., O'Connell, P., Nottle, M., dApice, A., Cowan, P., Kearns-Jonker, M. (2014). Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors. Xenotransplantation, 21(3), 244-253. [More Information]
  • Cantley, J., Walters, S., Jung, M., Weinberg, A., Cowley, M., Whitworth, P., Kaplan, W., Hawthorne, W., O'Connell, P., Weir, G., et al (2013). A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis. Cell Transplantation, 22(11), 2147-2159. [More Information]
  • Brady, J., Sutherland, R., Hancock, M., Kitsoulis, S., Lahoud, M., Phillips, P., Hawthorne, W., d'Apice, A., Cowan, P., Harrison, L., O'Connell, P., et al (2013). Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation, 20(2), 100-109. [More Information]
  • Stokes, R., Cheng, K., Deters, N., Lau, S., Hawthorne, W., O'Connell, P., Stolp, J., Grey, S., Loudovaris, T., Kay, T., Gunton, J., et al (2013). Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets. Cell Transplantation, 22(2), 253-266. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • O'Connell, P., Holmes-Walker, J., Goodman, D., Hawthorne, W., Loudovaris, T., Gunton, J., Thomas, H., Grey, S., Drogemuller, C., Ward, G., et al (2013). Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes. American Journal of Transplantation, 13(7), 1850-1858. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • Myint, T., Turner, R., Craig, J., Cross, N., Kable, K., Nankivell, B., Chapman, J., Webster, A., O'Connell, P., Dwyer, D., Jeoffreys, N., Wong, G., et al (2013). Test performance characteristics of quantitative nucleic acid testing for polyomaviruses in kidney and kidney-pancreas transplant recipients. Clinical Transplantation, 27(5), 571-579. [More Information]
  • O'Connell, P., Cowan, P., Hawthorne, W., Yi, S., Lew, A. (2013). Transplantation of Xenogeneic Islets: Are We There Yet? Current Diabetes Reports, 13(5), 687-694. [More Information]
  • Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P., Hawthorne, W., O'Connell, P. (2012). Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes, 61(5), 1180-1191. [More Information]
  • Campbell, P., Weinberg, A., Chee, J., Mariana, L., Ayala, R., Hawthorne, W., O'Connell, P., Loudovaris, T., Cowley, M., Kay, T., et al (2012). Expression of Pro- and Anti-apoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation. Cell Transplantation, 21(1), 49-60. [More Information]
  • Yeom, H., Koo, O., Yang, J., Cho, B., Hwang, J., Park, S., Hurh, S., Kim, H., Lee, E., Ro, H., O'Connell, P., et al (2012). Generation and characterization of human heme oxygenase-1 transgenic pigs. PLoS One, 7(10), 1-12. [More Information]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., O'Connell, P., et al (2012). Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplantation, 21(9), 2063-2078. [More Information]
  • Barton, F., Rickels, M., Alejandro, R., Hering, B., Wease, S., Naziruddin, B., Oberholzer, J., Odorico, J., Garfinkel, M., Levy, M., O'Connell, P., et al (2012). Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010. Diabetes Care, 35(7), 1436-1445. [More Information]
  • Chadban, S., Barraclough, K., Campbell, S., Clark, C., Coates, P., Cohney, S., Cross, N., Eris, J., Henderson, L., Howell, M., O'Connell, P., Webster, A., Wong, G., et al (2012). KHA-CARI guideline: KHA-CARI Adaptation of the KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients. Nephrology, 17(3), 204-214. [More Information]
  • Vincenti, F., Tedesco-Silva, H., Busque, S., O'Connell, P., Friedewald, J., Cibrik, D., Budde, K., Yoshida, A., Cohney, S., Weimar, W., et al (2012). Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year. American Journal Of Transplantation, 12(9), 2446-2456. [More Information]
  • Blyth, E., Clancy, L., Simms, R., Deo, S., O'Connell, P., Micklethwaite, K., Gottlieb, D. (2011). BK Virus-Specific T Cells for Use in Cellular Therapy Show Specificity to Multiple Antigens and Polyfunctional Cytokine Responses. Transplantation, 92(10), 1077-1084. [More Information]
  • Holdaas, H., Rostaing, L., Seron, D., Cole, E., Chapman, J., Fellstrom, B., Strom, E., Jardine, A., Midtvedt, K., Machein, U., O'Connell, P., et al (2011). Conversion of Long-Term Kidney Transplant Recipients From Calcineurin Inhibitor Therapy to Everolimus: A Randomized, Multicenter, 24-Month Study. Transplantation, 92(4), 410-418. [More Information]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Pre-clinical model of composite foetal pig pancreas fragment/renal xenotransplantation to treat renal failure and diabetes. Xenotransplantation, 18(6), 390-399. [More Information]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Subcapsular Fetal Pig Pancreas Fragment Transplantation Provides Normal Blood Glucose Control in a Preclinical Model of Diabetes. Transplantation, 91(5), 515-521. [More Information]
  • Ji, M., Yi, S., Smith-Hurst, H., Phillips, P., Wu, J., Hawthorne, W., O'Connell, P. (2011). The Importance of Tissue Factor Expression by Porcine NICC in Triggering IBMIR in the Xenograft Setting. Transplantation, 91(8), 841-846. [More Information]
  • Fisicaro, N., Londrigan, S., Brady, J., Salvaris, E., Nottle, M., O'Connell, P., Robson, S., d'Apice, A., Lew, A., Cowan, P. (2011). Versatile co-expression of graft-protective proteins using 2A-linked cassettes. Xenotransplantation, 18(2), 121-130. [More Information]
  • Sun, L., Yi, S., O'Connell, P. (2010). Foxp3 regulates human natural CD4+CD25+ regulatory T-cell-mediated suppression of xenogeneic response. Xenotransplantation, 17(2), 121-130. [More Information]
  • Akalin, E., O'Connell, P. (2010). Genomics of Chronic Allograft Injury. Kidney International, 78(Suppl 119), S33-S37. [More Information]
  • Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S., Hawthorne, W., O'Connell, P., Loudovaris, T., Kay, T., Kulkarni, R., Biankin, A., Kench, J., Gunton, J., et al (2010). Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. Journal of Clinical Investigation, 120(6), 2171-2183. [More Information]
  • Sun, L., Yi, S., O'Connell, P. (2010). IL-10 is required for human CD4+CD25+ regulatory T cell-mediated suppression of xenogeneic proliferation. Immunology and Cell Biology, 88(4), 477-485. [More Information]
  • Londrigan, S., Sutherland, R., Brady, J., Carrington, E., Cowan, P., d’Apice, A., O'Connell, P., Zhan, Y., Lew, A. (2010). In Situ Protection Against Islet Allograft Rejection by CTLA4Ig Transduction. Transplantation, 90(9), 951-957. [More Information]
  • O'Connell, P., Yi, S., Carrington, E., Lew, A. (2010). Role of regulatory T cells in xenotransplantation. Current Opinion in Organ Transplantation, 15(2), 224-229. [More Information]
  • Vitalone, M., O'Connell, P., Wavamunno, M., Fung, C., Chapman, J., Nankivell (Nankievell), B. (2010). Transcriptome Changes of Chronic Tubulointerstitial Damage in Early Kidney Transplantation. Transplantation, 89(5), 537-547. [More Information]
  • Cross, N., Webster, A., Masson, P., O'Connell, P., Craig, J. (2009). Antihypertensive treatment for kidney transplant recipients. Cochrane Database of Systematic Reviews, Article number CD003598(3), 1-157. [More Information]
  • Cross, N., Webster, A., Masson, P., O'Connell, P., Craig, J. (2009). Antihypertensives for kidney transplant recipients: systematic review and meta-analysis of randomized controlled trials. Transplantation, 88(1), 7-18. [More Information]
  • Cross, N., Webster, A., O'Connell, P., Jeffreys, N., Dwyer, D., Craig, J. (2009). Diagnostic accuracy of blood qualitative nucleic acid testing for polyomavirus-associated nephropathy in kidney recipients. Nephrology, 14(3), 350-356. [More Information]
  • Londrigan, S., Brady, J., Sutherland, R., Cowan, P., d'Apice, A., Hawthorne, W., O'Connell, P., Lew, A. (2009). Optimizing transduction of pig islet cell clusters for xenotransplantation. Xenotransplantation, 16(1), 45-46. [More Information]
  • Suh, N., Ryan, B., Allen, R., O'Connell, P., Pleass, H. (2009). Simultaneous pancreas and kidney transplantation from organ donation after cardiac death. ANZ Journal of Surgery, 79(4), 245-256. [More Information]
  • Hering, B., Cooper, D., Cozzi, E., Schuurman, H., Korbutt, G., Denner, J., O'Connell, P., Vanderpool, H., Pierson, R. (2009). The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-- executive summary. Xenotransplantation, 16(4), 196-202. [More Information]
  • O'Connell, P. (2009). The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 6: Patient selection for pilot clinical trials of islet xenotransplantation. Xenotransplantation, 16(4), 249-54. [More Information]
  • Akima, S., Hawthorne, W., Favaloro, E., Patel, A., Blyth, K., Mudaliar, M., Chapman, J., O'Connell, P. (2009). Tirofiban and Activated Protein C Synergistically Inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human Blood. American Journal Of Transplantation, 9, 1533-1540. [More Information]
  • Chapman, J., O'Connell, P. (2009). XXII International Congress of The Transplantation Society. Transplantation Proceedings, 41(1), 13. [More Information]
  • Vitalone, M., O'Connell, P., Jimenez, E., Yuksel, A., Wavamunno, M., Fung, C., Chapman, J., Nankivell (Nankievell), B. (2008). Epithelial-to-Mesenchymal Transition in Early Transplant Tubulointerstitial Damage. Journal of the American Society of Nephrology, 19(8), 1571-1583. [More Information]
  • Feller, J., Simpson, A., Nelson, M., O'Connell, P., Swan, M., Hawthorne, W., Tao, C., O'Brien, B. (2008). Growth Promoting Effect of Rh(D) Antibody on Human Pancreatic Islet Cells. Journal of Clinical Endocrinology and Metabolism, 93(9), 3560-3567. [More Information]
  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'Connell, P. (2008). In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation, 85(12), 1841-1848. [More Information]
  • Fu, Y., Yi, S., Wu, J., Jimenez-Vera, E., Simond, D., Hawthorne, W., O'Connell, P. (2008). In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation, 86(6), 865-874. [More Information]
  • Fu, Y., Lu, X., Yi, S., O'Hara, J., Hawthorne, W., Hucker, K., O'Connell, P. (2008). Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation, 15(5), 307-312. [More Information]
  • O'Connell, P. (2008). The rationale and practical issues for the maintenance of clean herds for clinical islet xenotransplantation. Xenotransplantation, 15(2), 91-92. [More Information]
  • Lehnert, A., Murray-Segal, L., Cowan, P., d'Apice, A., O'Connell, P. (2007). Blockade of the Passive Cell Death Pathway Does Not Prevent Tolerance Induction to Islet Grafts. Transplantation, 83(5), 653-655. [More Information]
  • Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha, H., Walters, S., Patel, A., Stokes, R., Jardine, M., Hawthorne, W., O'Connell, P. (2007). Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection. Xenotransplantation, 14(1), 48-59. [More Information]
  • Londrigan, S., Brady, J., Sutherland, R., Hawthorne, W., Thomas, H., Jhala, G., Cowan, P., Kay, T., O'Connell, P., Lew, A. (2007). Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets. Xenotransplantation, 14(2), 119-125. [More Information]
  • Nankivell (Nankievell), B., Wavamunno, M., Borrows, R., Vitalone, M., Fung, C., Allen, R., Chapman, J., O'Connell, P. (2007). Mycophenolate mofetil is associated with altered expression of chronic renal transplant histology. American Journal Of Transplantation, 7(2), 366-376. [More Information]
  • Nottle, M., Beebe, L., Harrison, S., McIlfatrick, S., Ashman, R., O'Connell, P., Salvaris, E., Fisicaro, N., Pommey, S., Cowan, P., et al (2007). Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation, 14(4), 339-344. [More Information]
  • Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J., Ouyang, L., Burgess, J., Hawthorne, W., Wu, H., Chadban, S., O'Connell, P. (2007). Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation, 83(5), 615-623. [More Information]
  • Wavamunno, M., O'Connell, P., Vitalone, M., Fung, C., Allen, R., Chapman, J., Nankivell (Nankievell), B. (2007). Transplant Glomerulopathy: Ultrastructural Abnormalities Occur Early in Longitudinal Analysis of Protocol Biopsies. American Journal Of Transplantation, 7(12), 2757-2768. [More Information]
  • O'Connell, P., Hawthorne, W., Holmes-Walker, D., Nankivell (Nankievell), B., Gunton, J., Patel, A., Walters, S., Pleass, H., Allen, R., Chapman, J. (2006). Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial. Medical Journal of Australia, 184(5), 221-225. [More Information]
  • Akima, S., Hawthorne, W., Koutts, J., Patel, A., Burgess, J., O'Hara, J., Mudaliar, Y., Favaloro, E., O'Connell, P. (2006). Differences in the efficacy of recombinant human activated protein C against allogeneic and xenogeneic IBMIR. 84(3), A16-A16.
  • Vitalone, M., Kirk, M., Allen, R., Pleass, H., Chapman, J., O'Connell, P., Nankivell (Nankievell), B. (2006). Epithelial-to-mesenchymal transition (EMT) in chronic allograft nephropathy (CAN). 84(3), A2-A2.
  • O'Connell, P., Lew, A., Cowan, P., Londrigan, S., Hawthorne, W., Nottle, M., d'Apice, A. (2006). Islet xenotransplantation: progress towards a clinical therapy. Current Opinion in Organ Transplantation, 11(2), 174-179.
  • Wavamunno, M., Vitalone, M., Borrows, R., Fung, C., Allen, R., O'Connell, P., Chapman, J., Nankivell (Nankievell), B. (2006). Mycophenolate mofetil reduces the histological expression of chronic allograft nephropathy. Immunology and Cell Biology, 84(3), A11-A11.
  • Robertson, P., Allen, R., O'Connell, P., Pleass, H., Nankivell (Nankievell), B., Waugh, D., Chapman, J. (2006). Transplant beta cell function and the 'lazarus factor'. 84(3), A10-A10.
  • Chapman, J., Allen, R., Nankivell (Nankievell), B., O'Connell, P., Fung, C., Kee, T., Kable, K., Vitalone, M. (2006). Treatment of Subclinical Rejection Diagnosed by Protocol Biopsy of Kidney Transplants. Transplantation, 82(1), 36-42. [More Information]
  • Allen, R., Lau, H., Nankivell (Nankievell), B., O'Connell, P., Lennox, A., Pussell, B., Chapman, J. (2006). When all the planets are in alignment. 84 (Suppl.)(3), A22-A22.
  • Wong, K., Kable, K., Hawthorne, W., Robertson, P., Chan, K., Nankivell (Nankievell), B., O'Connell, P., Chapman, J., Lau, H., Pleass, H., Allen, R. (2005). A comparison of 2 surgical techniques in pancreas transplantation. Immunology and Cell Biology, 83(4), A23-A24.
  • Lee, J., Simond, D., Hawthorne, W., Walters, S., Patel, A., Smith, D., O'Connell, P., Moran, C. (2005). Characterization of the swine major histocompatibility complex alleles at eight loci in Westran pigs. Xenotransplantation, 12(4), 303-307. [More Information]
  • Chapman, J., O'Connell, P., Nankivell (Nankievell), B. (2005). Chronic renal allograft dysfunction. Journal of the American Society of Nephrology, 16(10), 3015-3026. [More Information]
  • O'Connell, P., Hawthorne, W., Simond, D., Chapman, J., Chen, Y., Patel, A., Walters, S., Burgess, J., Weston, L., Stokes, R., Moran, C., Allen, R. (2005). Genetic and Functional evaluation of the level of inbreeding of the Westran pig: a herd with potential for use in xenotransplantation. Xenotransplantation, 12(4), 308-315. [More Information]
  • Davidson, J., Dotta, F., Home, P., Keown, P., Jardine, A., O'Connell, P., Schnitzler, M., Torregosa, J., Valantine, H., Villamil, F., et al (2005). Guidelines for the treatment and management of new-onset diabetes after transplantation. Clinical Transplantation, 19(3), 291-8. [More Information]
  • Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra, A., Akima, S., Hawthorne, W., Patel, A., Stokes, R., O'Connell, P. (2005). Involvement of CCR5 Signaling in Macrophage Recruitment to Porcine Islet Xenografts. Transplantation, 80(10), 1468-1475. [More Information]
  • Thiel, M., Steiger, J., O'Connell, P., Lehnert, A., Coster, D., Williams, K. (2005). Local or short-term systemic costimulatory molecule blockade prolongs rat corneal allograft survival. Clinical and Experimental Ophthalmology, 33, 176-180. [More Information]
  • Gunton, J., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W., Tseng, Y., Roberson, R., Ricordi, C., O'Connell, P., Gonzalez, F., et al (2005). Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell, 122(3), 337-349. [More Information]
  • Mysore, T., Shinkel, T., Collins, J., Salvaris, E., Fisicaro, N., Murray-Segal, L., Johnson, L., Lepore, D., Walters, S., Stokes, R., Chandra, A., O'Connell, P., et al (2005). Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function. Diabetes, 54(7), 2109-16. [More Information]
  • Wavamunno, M., Nankivell (Nankievell), B., Chapman, J., Kable, K., Allen, R., Pleass, H., O'Connell, P. (2005). The impact of screening for BK virus in renal allograft recipients. Immunology and Cell Biology, 83(4), A15-A16.
  • Vitalone, M., Nankivell (Nankievell), B., Kirk, M., Allen, R., Pleass, H., Lau, H., Chapman, J., O'Connell, P. (2005). The use of gene arrays to study the pathogenesis of chronic allograft nephropathy (CAN). Immunology and Cell Biology, 83(4), A26-A26.
  • O'Connell, P. (2005). Thrombotic microangiopathy: the next big hurdle for xenotransplantation. Journal of the American Society of Nephrology, 16(9), 2529-30. [More Information]
  • Harrison, S., Boquest, A., Grupen, C., Faast, R., Guildolin, A., Giannakis, C., Crocker, L., McIlfatrick, S., Ashman, R., Wengle, J., O'Connell, P., d'Apice, A., et al (2004). An Efficient Method for Producing α(1,3)-Galactosyltransferase Gene Knockout Pigs. Cloning and Stem Cells, 6(4), 327-331.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Chapman, J., Allen, R. (2004). Calcineurin Inhibitor Nephrotoxicity: Longitudinal Assessment By Protocol Histology. Transplantation, 78(4), 557-565.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Chapman, J., Allen, R. (2004). Delta Analysis Of Posttransplantation Tubulointerstitial Damage. Transplantation, 78(3), 434-441.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. (2004). Evolution And Pathophysiology Of Renal-Transplant Glomerulosclerosis. Transplantation, 78(3), 461-468.
  • Chandra, A., Salvaris, E., Walters, S., Murray-Segal, L., Gock, H., Lehnert, A., Wong, J., Cowan, P., d'Apice, A., O'Connell, P. (2004). Fate Of Alphagal +/+ Pancreatic Islet Grafts After Transplantation Into Alphagal Knockout Mice. Xenotransplantation, 11(4), 323-331.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. (2004). Natural History, Risk Factors, And Impact Of Subclinical Rejection In Kidney Transplantation. Transplantation, 78(2), 242-249.
  • Zhan, Y., Brown, L., Deliyannis, G., Seah, S., Wijburg, O., Price, J., Strugnell, R., O'Connell, P., Lew, A. (2004). Responses Against Complex Antigens In Various Models Of Cd4 T-Cell Deficiency: Surprises From An Anti-Cd4 Antibody Transgenic Mouse. Immunologic Research, 30(1), 1-14.
  • Russ, G., Campbell, S., Chadban, S., Eris, J., O'Connell, P., Pussell, B., Walker, R. (2003). Reduced and standard target concentration tacrolimus with sirolimus in renal allograft recipients. Transplantation Proceedings, 35(3), 115S-117S.
  • Yi, S., Hawthorne, W., Lehnert, A., Ha, H., Wong, J., Rooijen, N., Davey, K., Patel, A., Walters, S., Chandra, A., O'Connell, P. (2003). T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts. Journal of Immunology, 170(5), 2750-2758.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. (2003). The natural history of chronic allograft nephropathy. New England Journal of Medicine, 349(24), 2326-2333.
  • Lehnert, A., Hawthorne, W., O'Connell, P., Mottram, P., Han, W., Walters, S., Patel, A., Cowan, P., d'Apice, A. (2001). Blockage of the cd28 and cd40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice. Transplant Immunology, 9, 51-56.
  • Nankivell (Nankievell), B., Fenton Lee, C., Allen, R., O'Connell, P., Chapman, J., Kuypers, D., Cheung,, E. (2001). Effect of Histological damage on long-term kidney transplant outcome. Transplantation, 71, 515-523.
  • Nankivell (Nankievell), B., Fenton Lee, C., Allen, R., O'Connell, P., Chapman, J., Kuypers, D. (2001). Histological injury and renal transplant outcome: the cumulative damage hypothesis. Transplantation Proceedings, 33, 1149-1150.
  • Allen, R., Nankivell (Nankievell), B., Hawthorne, W., O'Connell, P., Chapman, J. (2001). Pancreas and islet transplantation: an unfinished journey. Transplantation Proceedings, 33, 3485-3488.
  • Hawthorne, W., Cachia, A., Walters, S., Patel, A., Clarke, J., O'Connell, P., Chapman, J., Allen, R. (2000). A large-animal model to evaluate the clinical potential of fetal pig pancreas fragment transplantation. Cell Transplantation, 9, 867-875.
  • Horton, P., Hawthorne, W., Walters, S., Patel, A., O'Connell, P., Chapman, J., Allen, R. (2000). Induction of allogenic islet tolerance in a large-animal model. Cell Transplantation, 9, 877-887.
  • Wallman, L., Stewart, G., Chapman, J., O'Connell, P., Fulcher, D. (2000). Mycophenolate mofetil for treatment of refractory lupus nephritis: four pilot cases. Internal Medicine Journal, 30, 712-715.
  • Pai, R., Mitchell, P., Chow, C., Chapman, J., O'Connell, P., Allen, R., Nankivell (Nankievell), B. (2000). Posttransplant cataract: lessons from kidney-pancreas transplantation. Transplantation, 69, 1108-1114.
  • Nankivell (Nankievell), B., Lau, S., Chapman, J., O'Connell, P., Fletcher, J., Allen, R. (2000). Progression of macrovascular disease after transplantation. Transplantation, 69, 574-581.

Conferences

  • Goddard, K., Pleass, H., Cross, N., O'Connell, P., Chapman, J., Nankivell (Nankievell), B., Allen, R. (2006). A twist of fate or fated to twist?
  • Hawthorne, W., Patel, A., O'Hara, J., Akima, S., Salvaris, E., Nottle, M., d'Aspice, A., Cowan, P., O'Connell, P. (2006). Elimination of the alpha Gal antigen on NICC reduces ibmir following exposure of pig NICC to human blood. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Chandra, A., Wong, J., Yi, S., Ha, H., Patel, A., O'Connell, P., Hawthorne, W. (2006). Lack of IL-15 reduces recruitment of xenoreactive leukocytes into discordant islet xenografts but does not prolong graft survival. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Simond, D., Moran, C., Garkavenko, O., O'Connell, P., Hawthorne, W. (2006). Real-time PCR detection of porcine endogenous retroviruses. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Hawthorne, W., Stokes, R., Patel, A., Burgess, J., Walters, S., Simond, D., O'Connell, P. (2006). Westran fetal pig pancreas fragment transplants provide long-term normoglycaemia in adult pi. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.

2014

  • Huang, J., Zheng, S., Liu, Y., Wang, H., Chapman, J., O'Connell, P., Millis, M., Fung, J., Delmonico, F. (2014). China organ donation and transplantation update: the Hangzhou Resolution. Hepatobiliary & Pancreatic Diseases International, 13(2), 122-124. [More Information]
  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation, 97(1), 30-38. [More Information]
  • Chen, Y., Stewart, J., Gunthart, M., Hawthorne, W., Salvaris, E., O'Connell, P., Nottle, M., dApice, A., Cowan, P., Kearns-Jonker, M. (2014). Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors. Xenotransplantation, 21(3), 244-253. [More Information]

2013

  • Cantley, J., Walters, S., Jung, M., Weinberg, A., Cowley, M., Whitworth, P., Kaplan, W., Hawthorne, W., O'Connell, P., Weir, G., et al (2013). A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis. Cell Transplantation, 22(11), 2147-2159. [More Information]
  • Brady, J., Sutherland, R., Hancock, M., Kitsoulis, S., Lahoud, M., Phillips, P., Hawthorne, W., d'Apice, A., Cowan, P., Harrison, L., O'Connell, P., et al (2013). Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation, 20(2), 100-109. [More Information]
  • Stokes, R., Cheng, K., Deters, N., Lau, S., Hawthorne, W., O'Connell, P., Stolp, J., Grey, S., Loudovaris, T., Kay, T., Gunton, J., et al (2013). Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets. Cell Transplantation, 22(2), 253-266. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • O'Connell, P., Holmes-Walker, J., Goodman, D., Hawthorne, W., Loudovaris, T., Gunton, J., Thomas, H., Grey, S., Drogemuller, C., Ward, G., et al (2013). Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes. American Journal of Transplantation, 13(7), 1850-1858. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • Myint, T., Turner, R., Craig, J., Cross, N., Kable, K., Nankivell, B., Chapman, J., Webster, A., O'Connell, P., Dwyer, D., Jeoffreys, N., Wong, G., et al (2013). Test performance characteristics of quantitative nucleic acid testing for polyomaviruses in kidney and kidney-pancreas transplant recipients. Clinical Transplantation, 27(5), 571-579. [More Information]
  • O'Connell, P., Cowan, P., Hawthorne, W., Yi, S., Lew, A. (2013). Transplantation of Xenogeneic Islets: Are We There Yet? Current Diabetes Reports, 13(5), 687-694. [More Information]

2012

  • Donaghue, K., Keech, A., Craig, M., O'Connell, P. (2012). A 'cure' for diabetes and its complications. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 401-420). Sydney, Australia: Sydney University Press.
  • Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P., Hawthorne, W., O'Connell, P. (2012). Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes, 61(5), 1180-1191. [More Information]
  • Campbell, P., Weinberg, A., Chee, J., Mariana, L., Ayala, R., Hawthorne, W., O'Connell, P., Loudovaris, T., Cowley, M., Kay, T., et al (2012). Expression of Pro- and Anti-apoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation. Cell Transplantation, 21(1), 49-60. [More Information]
  • Yeom, H., Koo, O., Yang, J., Cho, B., Hwang, J., Park, S., Hurh, S., Kim, H., Lee, E., Ro, H., O'Connell, P., et al (2012). Generation and characterization of human heme oxygenase-1 transgenic pigs. PLoS One, 7(10), 1-12. [More Information]
  • Cowley, M., Weinberg, A., Zammit, N., Walters, S., Hawthorne, W., Loudovaris, T., Thomas, H., Kay, T., Gunton, J., Alexander, S., O'Connell, P., et al (2012). Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplantation, 21(9), 2063-2078. [More Information]
  • Barton, F., Rickels, M., Alejandro, R., Hering, B., Wease, S., Naziruddin, B., Oberholzer, J., Odorico, J., Garfinkel, M., Levy, M., O'Connell, P., et al (2012). Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010. Diabetes Care, 35(7), 1436-1445. [More Information]
  • Chadban, S., Barraclough, K., Campbell, S., Clark, C., Coates, P., Cohney, S., Cross, N., Eris, J., Henderson, L., Howell, M., O'Connell, P., Webster, A., Wong, G., et al (2012). KHA-CARI guideline: KHA-CARI Adaptation of the KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients. Nephrology, 17(3), 204-214. [More Information]
  • Vincenti, F., Tedesco-Silva, H., Busque, S., O'Connell, P., Friedewald, J., Cibrik, D., Budde, K., Yoshida, A., Cohney, S., Weimar, W., et al (2012). Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year. American Journal Of Transplantation, 12(9), 2446-2456. [More Information]

2011

  • Blyth, E., Clancy, L., Simms, R., Deo, S., O'Connell, P., Micklethwaite, K., Gottlieb, D. (2011). BK Virus-Specific T Cells for Use in Cellular Therapy Show Specificity to Multiple Antigens and Polyfunctional Cytokine Responses. Transplantation, 92(10), 1077-1084. [More Information]
  • Holdaas, H., Rostaing, L., Seron, D., Cole, E., Chapman, J., Fellstrom, B., Strom, E., Jardine, A., Midtvedt, K., Machein, U., O'Connell, P., et al (2011). Conversion of Long-Term Kidney Transplant Recipients From Calcineurin Inhibitor Therapy to Everolimus: A Randomized, Multicenter, 24-Month Study. Transplantation, 92(4), 410-418. [More Information]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Pre-clinical model of composite foetal pig pancreas fragment/renal xenotransplantation to treat renal failure and diabetes. Xenotransplantation, 18(6), 390-399. [More Information]
  • Hawthorne, W., Simond, D., Stokes, R., Patel, A., Walters, S., Burgess, J., O'Connell, P. (2011). Subcapsular Fetal Pig Pancreas Fragment Transplantation Provides Normal Blood Glucose Control in a Preclinical Model of Diabetes. Transplantation, 91(5), 515-521. [More Information]
  • Ji, M., Yi, S., Smith-Hurst, H., Phillips, P., Wu, J., Hawthorne, W., O'Connell, P. (2011). The Importance of Tissue Factor Expression by Porcine NICC in Triggering IBMIR in the Xenograft Setting. Transplantation, 91(8), 841-846. [More Information]
  • Fisicaro, N., Londrigan, S., Brady, J., Salvaris, E., Nottle, M., O'Connell, P., Robson, S., d'Apice, A., Lew, A., Cowan, P. (2011). Versatile co-expression of graft-protective proteins using 2A-linked cassettes. Xenotransplantation, 18(2), 121-130. [More Information]

2010

  • Sun, L., Yi, S., O'Connell, P. (2010). Foxp3 regulates human natural CD4+CD25+ regulatory T-cell-mediated suppression of xenogeneic response. Xenotransplantation, 17(2), 121-130. [More Information]
  • Akalin, E., O'Connell, P. (2010). Genomics of Chronic Allograft Injury. Kidney International, 78(Suppl 119), S33-S37. [More Information]
  • Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S., Hawthorne, W., O'Connell, P., Loudovaris, T., Kay, T., Kulkarni, R., Biankin, A., Kench, J., Gunton, J., et al (2010). Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. Journal of Clinical Investigation, 120(6), 2171-2183. [More Information]
  • Sun, L., Yi, S., O'Connell, P. (2010). IL-10 is required for human CD4+CD25+ regulatory T cell-mediated suppression of xenogeneic proliferation. Immunology and Cell Biology, 88(4), 477-485. [More Information]
  • Londrigan, S., Sutherland, R., Brady, J., Carrington, E., Cowan, P., d’Apice, A., O'Connell, P., Zhan, Y., Lew, A. (2010). In Situ Protection Against Islet Allograft Rejection by CTLA4Ig Transduction. Transplantation, 90(9), 951-957. [More Information]
  • O'Connell, P., Yi, S., Carrington, E., Lew, A. (2010). Role of regulatory T cells in xenotransplantation. Current Opinion in Organ Transplantation, 15(2), 224-229. [More Information]
  • Vitalone, M., O'Connell, P., Wavamunno, M., Fung, C., Chapman, J., Nankivell (Nankievell), B. (2010). Transcriptome Changes of Chronic Tubulointerstitial Damage in Early Kidney Transplantation. Transplantation, 89(5), 537-547. [More Information]

2009

  • Cross, N., Webster, A., Masson, P., O'Connell, P., Craig, J. (2009). Antihypertensive treatment for kidney transplant recipients. Cochrane Database of Systematic Reviews, Article number CD003598(3), 1-157. [More Information]
  • Cross, N., Webster, A., Masson, P., O'Connell, P., Craig, J. (2009). Antihypertensives for kidney transplant recipients: systematic review and meta-analysis of randomized controlled trials. Transplantation, 88(1), 7-18. [More Information]
  • Cross, N., Webster, A., O'Connell, P., Jeffreys, N., Dwyer, D., Craig, J. (2009). Diagnostic accuracy of blood qualitative nucleic acid testing for polyomavirus-associated nephropathy in kidney recipients. Nephrology, 14(3), 350-356. [More Information]
  • Londrigan, S., Brady, J., Sutherland, R., Cowan, P., d'Apice, A., Hawthorne, W., O'Connell, P., Lew, A. (2009). Optimizing transduction of pig islet cell clusters for xenotransplantation. Xenotransplantation, 16(1), 45-46. [More Information]
  • Suh, N., Ryan, B., Allen, R., O'Connell, P., Pleass, H. (2009). Simultaneous pancreas and kidney transplantation from organ donation after cardiac death. ANZ Journal of Surgery, 79(4), 245-256. [More Information]
  • Hering, B., Cooper, D., Cozzi, E., Schuurman, H., Korbutt, G., Denner, J., O'Connell, P., Vanderpool, H., Pierson, R. (2009). The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-- executive summary. Xenotransplantation, 16(4), 196-202. [More Information]
  • O'Connell, P. (2009). The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 6: Patient selection for pilot clinical trials of islet xenotransplantation. Xenotransplantation, 16(4), 249-54. [More Information]
  • Akima, S., Hawthorne, W., Favaloro, E., Patel, A., Blyth, K., Mudaliar, M., Chapman, J., O'Connell, P. (2009). Tirofiban and Activated Protein C Synergistically Inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human Blood. American Journal Of Transplantation, 9, 1533-1540. [More Information]
  • Chapman, J., O'Connell, P. (2009). XXII International Congress of The Transplantation Society. Transplantation Proceedings, 41(1), 13. [More Information]

2008

  • Vitalone, M., O'Connell, P., Jimenez, E., Yuksel, A., Wavamunno, M., Fung, C., Chapman, J., Nankivell (Nankievell), B. (2008). Epithelial-to-Mesenchymal Transition in Early Transplant Tubulointerstitial Damage. Journal of the American Society of Nephrology, 19(8), 1571-1583. [More Information]
  • Feller, J., Simpson, A., Nelson, M., O'Connell, P., Swan, M., Hawthorne, W., Tao, C., O'Brien, B. (2008). Growth Promoting Effect of Rh(D) Antibody on Human Pancreatic Islet Cells. Journal of Clinical Endocrinology and Metabolism, 93(9), 3560-3567. [More Information]
  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'Connell, P. (2008). In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation, 85(12), 1841-1848. [More Information]
  • Fu, Y., Yi, S., Wu, J., Jimenez-Vera, E., Simond, D., Hawthorne, W., O'Connell, P. (2008). In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation, 86(6), 865-874. [More Information]
  • Fu, Y., Lu, X., Yi, S., O'Hara, J., Hawthorne, W., Hucker, K., O'Connell, P. (2008). Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation, 15(5), 307-312. [More Information]
  • O'Connell, P. (2008). The rationale and practical issues for the maintenance of clean herds for clinical islet xenotransplantation. Xenotransplantation, 15(2), 91-92. [More Information]

2007

  • Lehnert, A., Murray-Segal, L., Cowan, P., d'Apice, A., O'Connell, P. (2007). Blockade of the Passive Cell Death Pathway Does Not Prevent Tolerance Induction to Islet Grafts. Transplantation, 83(5), 653-655. [More Information]
  • Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha, H., Walters, S., Patel, A., Stokes, R., Jardine, M., Hawthorne, W., O'Connell, P. (2007). Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection. Xenotransplantation, 14(1), 48-59. [More Information]
  • Londrigan, S., Brady, J., Sutherland, R., Hawthorne, W., Thomas, H., Jhala, G., Cowan, P., Kay, T., O'Connell, P., Lew, A. (2007). Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets. Xenotransplantation, 14(2), 119-125. [More Information]
  • Nankivell (Nankievell), B., Wavamunno, M., Borrows, R., Vitalone, M., Fung, C., Allen, R., Chapman, J., O'Connell, P. (2007). Mycophenolate mofetil is associated with altered expression of chronic renal transplant histology. American Journal Of Transplantation, 7(2), 366-376. [More Information]
  • Nottle, M., Beebe, L., Harrison, S., McIlfatrick, S., Ashman, R., O'Connell, P., Salvaris, E., Fisicaro, N., Pommey, S., Cowan, P., et al (2007). Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation, 14(4), 339-344. [More Information]
  • Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J., Ouyang, L., Burgess, J., Hawthorne, W., Wu, H., Chadban, S., O'Connell, P. (2007). Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation, 83(5), 615-623. [More Information]
  • Wavamunno, M., O'Connell, P., Vitalone, M., Fung, C., Allen, R., Chapman, J., Nankivell (Nankievell), B. (2007). Transplant Glomerulopathy: Ultrastructural Abnormalities Occur Early in Longitudinal Analysis of Protocol Biopsies. American Journal Of Transplantation, 7(12), 2757-2768. [More Information]

2006

  • Goddard, K., Pleass, H., Cross, N., O'Connell, P., Chapman, J., Nankivell (Nankievell), B., Allen, R. (2006). A twist of fate or fated to twist?
  • O'Connell, P., Hawthorne, W., Holmes-Walker, D., Nankivell (Nankievell), B., Gunton, J., Patel, A., Walters, S., Pleass, H., Allen, R., Chapman, J. (2006). Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial. Medical Journal of Australia, 184(5), 221-225. [More Information]
  • Akima, S., Hawthorne, W., Koutts, J., Patel, A., Burgess, J., O'Hara, J., Mudaliar, Y., Favaloro, E., O'Connell, P. (2006). Differences in the efficacy of recombinant human activated protein C against allogeneic and xenogeneic IBMIR. 84(3), A16-A16.
  • Hawthorne, W., Patel, A., O'Hara, J., Akima, S., Salvaris, E., Nottle, M., d'Aspice, A., Cowan, P., O'Connell, P. (2006). Elimination of the alpha Gal antigen on NICC reduces ibmir following exposure of pig NICC to human blood. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Vitalone, M., Kirk, M., Allen, R., Pleass, H., Chapman, J., O'Connell, P., Nankivell (Nankievell), B. (2006). Epithelial-to-mesenchymal transition (EMT) in chronic allograft nephropathy (CAN). 84(3), A2-A2.
  • O'Connell, P., Lew, A., Cowan, P., Londrigan, S., Hawthorne, W., Nottle, M., d'Apice, A. (2006). Islet xenotransplantation: progress towards a clinical therapy. Current Opinion in Organ Transplantation, 11(2), 174-179.
  • Chandra, A., Wong, J., Yi, S., Ha, H., Patel, A., O'Connell, P., Hawthorne, W. (2006). Lack of IL-15 reduces recruitment of xenoreactive leukocytes into discordant islet xenografts but does not prolong graft survival. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wavamunno, M., Vitalone, M., Borrows, R., Fung, C., Allen, R., O'Connell, P., Chapman, J., Nankivell (Nankievell), B. (2006). Mycophenolate mofetil reduces the histological expression of chronic allograft nephropathy. Immunology and Cell Biology, 84(3), A11-A11.
  • Simond, D., Moran, C., Garkavenko, O., O'Connell, P., Hawthorne, W. (2006). Real-time PCR detection of porcine endogenous retroviruses. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Robertson, P., Allen, R., O'Connell, P., Pleass, H., Nankivell (Nankievell), B., Waugh, D., Chapman, J. (2006). Transplant beta cell function and the 'lazarus factor'. 84(3), A10-A10.
  • Chapman, J., Allen, R., Nankivell (Nankievell), B., O'Connell, P., Fung, C., Kee, T., Kable, K., Vitalone, M. (2006). Treatment of Subclinical Rejection Diagnosed by Protocol Biopsy of Kidney Transplants. Transplantation, 82(1), 36-42. [More Information]
  • Hawthorne, W., Stokes, R., Patel, A., Burgess, J., Walters, S., Simond, D., O'Connell, P. (2006). Westran fetal pig pancreas fragment transplants provide long-term normoglycaemia in adult pi. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Allen, R., Lau, H., Nankivell (Nankievell), B., O'Connell, P., Lennox, A., Pussell, B., Chapman, J. (2006). When all the planets are in alignment. 84 (Suppl.)(3), A22-A22.

2005

  • Wong, K., Kable, K., Hawthorne, W., Robertson, P., Chan, K., Nankivell (Nankievell), B., O'Connell, P., Chapman, J., Lau, H., Pleass, H., Allen, R. (2005). A comparison of 2 surgical techniques in pancreas transplantation. Immunology and Cell Biology, 83(4), A23-A24.
  • Lee, J., Simond, D., Hawthorne, W., Walters, S., Patel, A., Smith, D., O'Connell, P., Moran, C. (2005). Characterization of the swine major histocompatibility complex alleles at eight loci in Westran pigs. Xenotransplantation, 12(4), 303-307. [More Information]
  • Chapman, J., O'Connell, P., Nankivell (Nankievell), B. (2005). Chronic renal allograft dysfunction. Journal of the American Society of Nephrology, 16(10), 3015-3026. [More Information]
  • O'Connell, P., Hawthorne, W., Simond, D., Chapman, J., Chen, Y., Patel, A., Walters, S., Burgess, J., Weston, L., Stokes, R., Moran, C., Allen, R. (2005). Genetic and Functional evaluation of the level of inbreeding of the Westran pig: a herd with potential for use in xenotransplantation. Xenotransplantation, 12(4), 308-315. [More Information]
  • Davidson, J., Dotta, F., Home, P., Keown, P., Jardine, A., O'Connell, P., Schnitzler, M., Torregosa, J., Valantine, H., Villamil, F., et al (2005). Guidelines for the treatment and management of new-onset diabetes after transplantation. Clinical Transplantation, 19(3), 291-8. [More Information]
  • Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra, A., Akima, S., Hawthorne, W., Patel, A., Stokes, R., O'Connell, P. (2005). Involvement of CCR5 Signaling in Macrophage Recruitment to Porcine Islet Xenografts. Transplantation, 80(10), 1468-1475. [More Information]
  • Thiel, M., Steiger, J., O'Connell, P., Lehnert, A., Coster, D., Williams, K. (2005). Local or short-term systemic costimulatory molecule blockade prolongs rat corneal allograft survival. Clinical and Experimental Ophthalmology, 33, 176-180. [More Information]
  • Gunton, J., Kulkarni, R., Yim, S., Okada, T., Hawthorne, W., Tseng, Y., Roberson, R., Ricordi, C., O'Connell, P., Gonzalez, F., et al (2005). Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell, 122(3), 337-349. [More Information]
  • Mysore, T., Shinkel, T., Collins, J., Salvaris, E., Fisicaro, N., Murray-Segal, L., Johnson, L., Lepore, D., Walters, S., Stokes, R., Chandra, A., O'Connell, P., et al (2005). Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function. Diabetes, 54(7), 2109-16. [More Information]
  • Wavamunno, M., Nankivell (Nankievell), B., Chapman, J., Kable, K., Allen, R., Pleass, H., O'Connell, P. (2005). The impact of screening for BK virus in renal allograft recipients. Immunology and Cell Biology, 83(4), A15-A16.
  • Vitalone, M., Nankivell (Nankievell), B., Kirk, M., Allen, R., Pleass, H., Lau, H., Chapman, J., O'Connell, P. (2005). The use of gene arrays to study the pathogenesis of chronic allograft nephropathy (CAN). Immunology and Cell Biology, 83(4), A26-A26.
  • O'Connell, P. (2005). Thrombotic microangiopathy: the next big hurdle for xenotransplantation. Journal of the American Society of Nephrology, 16(9), 2529-30. [More Information]

2004

  • Harrison, S., Boquest, A., Grupen, C., Faast, R., Guildolin, A., Giannakis, C., Crocker, L., McIlfatrick, S., Ashman, R., Wengle, J., O'Connell, P., d'Apice, A., et al (2004). An Efficient Method for Producing α(1,3)-Galactosyltransferase Gene Knockout Pigs. Cloning and Stem Cells, 6(4), 327-331.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Chapman, J., Allen, R. (2004). Calcineurin Inhibitor Nephrotoxicity: Longitudinal Assessment By Protocol Histology. Transplantation, 78(4), 557-565.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Chapman, J., Allen, R. (2004). Delta Analysis Of Posttransplantation Tubulointerstitial Damage. Transplantation, 78(3), 434-441.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. (2004). Evolution And Pathophysiology Of Renal-Transplant Glomerulosclerosis. Transplantation, 78(3), 461-468.
  • Chandra, A., Salvaris, E., Walters, S., Murray-Segal, L., Gock, H., Lehnert, A., Wong, J., Cowan, P., d'Apice, A., O'Connell, P. (2004). Fate Of Alphagal +/+ Pancreatic Islet Grafts After Transplantation Into Alphagal Knockout Mice. Xenotransplantation, 11(4), 323-331.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. (2004). Natural History, Risk Factors, And Impact Of Subclinical Rejection In Kidney Transplantation. Transplantation, 78(2), 242-249.
  • Zhan, Y., Brown, L., Deliyannis, G., Seah, S., Wijburg, O., Price, J., Strugnell, R., O'Connell, P., Lew, A. (2004). Responses Against Complex Antigens In Various Models Of Cd4 T-Cell Deficiency: Surprises From An Anti-Cd4 Antibody Transgenic Mouse. Immunologic Research, 30(1), 1-14.

2003

  • Russ, G., Campbell, S., Chadban, S., Eris, J., O'Connell, P., Pussell, B., Walker, R. (2003). Reduced and standard target concentration tacrolimus with sirolimus in renal allograft recipients. Transplantation Proceedings, 35(3), 115S-117S.
  • Yi, S., Hawthorne, W., Lehnert, A., Ha, H., Wong, J., Rooijen, N., Davey, K., Patel, A., Walters, S., Chandra, A., O'Connell, P. (2003). T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts. Journal of Immunology, 170(5), 2750-2758.
  • Nankivell (Nankievell), B., Borrows, R., Fung, C., O'Connell, P., Allen, R., Chapman, J. (2003). The natural history of chronic allograft nephropathy. New England Journal of Medicine, 349(24), 2326-2333.

2001

  • Lehnert, A., Hawthorne, W., O'Connell, P., Mottram, P., Han, W., Walters, S., Patel, A., Cowan, P., d'Apice, A. (2001). Blockage of the cd28 and cd40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice. Transplant Immunology, 9, 51-56.
  • Nankivell (Nankievell), B., Fenton Lee, C., Allen, R., O'Connell, P., Chapman, J., Kuypers, D., Cheung,, E. (2001). Effect of Histological damage on long-term kidney transplant outcome. Transplantation, 71, 515-523.
  • Nankivell (Nankievell), B., Fenton Lee, C., Allen, R., O'Connell, P., Chapman, J., Kuypers, D. (2001). Histological injury and renal transplant outcome: the cumulative damage hypothesis. Transplantation Proceedings, 33, 1149-1150.
  • Allen, R., Nankivell (Nankievell), B., Hawthorne, W., O'Connell, P., Chapman, J. (2001). Pancreas and islet transplantation: an unfinished journey. Transplantation Proceedings, 33, 3485-3488.

2000

  • Hawthorne, W., Cachia, A., Walters, S., Patel, A., Clarke, J., O'Connell, P., Chapman, J., Allen, R. (2000). A large-animal model to evaluate the clinical potential of fetal pig pancreas fragment transplantation. Cell Transplantation, 9, 867-875.
  • Horton, P., Hawthorne, W., Walters, S., Patel, A., O'Connell, P., Chapman, J., Allen, R. (2000). Induction of allogenic islet tolerance in a large-animal model. Cell Transplantation, 9, 877-887.
  • Wallman, L., Stewart, G., Chapman, J., O'Connell, P., Fulcher, D. (2000). Mycophenolate mofetil for treatment of refractory lupus nephritis: four pilot cases. Internal Medicine Journal, 30, 712-715.
  • Pai, R., Mitchell, P., Chow, C., Chapman, J., O'Connell, P., Allen, R., Nankivell (Nankievell), B. (2000). Posttransplant cataract: lessons from kidney-pancreas transplantation. Transplantation, 69, 1108-1114.
  • Nankivell (Nankievell), B., Lau, S., Chapman, J., O'Connell, P., Fletcher, J., Allen, R. (2000). Progression of macrovascular disease after transplantation. Transplantation, 69, 574-581.

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