Professor Phillip Robinson

Professor
Medicine, Children's Medical Research Institute

Telephone 02 8865 2915
Fax 02 9687 2120

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Biographical details

Phil has a B.Sci. (Hons) in Biochemistry from Sydney University and in 1984 he completed a PhD in Medical Biochemistry at the University of Newcastle. After postdoctoral studies at the National Institutes of Health (NIH, USA), Merrell Dow Research Institute Cincinnati, and St. Vincent's Institute of Medical Research Melbourne, he became Principal Hospital Scientist at the John Hunter Hospital Newcastle. He took up his present position as Head of the Cell Signalling Unit at the Children’s Medical Research Institute (CMRI) Sydney in 1996 and is also a Professor in Medicine at the Universities of Sydney and Newcastle, and is one of only ~70 Australian scientists holding a Principal Research Fellowship from the NHMRC. He leads a team of 21 scientists, postdocs and graduate students.

Research interests

His research program focuses on understanding the molecular mechanisms of synaptic transmission in the nervous system. His work brings together cell signalling with protein chemistry and medicinal chemistries to: a) understand the basic science of nerve communication and b) develop drugs to control diseases of nerve terminals like epilepsy. Nerve communication involves neurotransmitter release at contact points between nerves – synapses. It occurs from small storage vesicles, synaptic vesicles, which accumulate at synapses. They must be recycled locally or synaptic transmission stops, resulting in paralysis. The main focus is on proteins called the dynamins, which are self-assembling molecular machines acting in many intracellular functions. Dynamin can self-assemble as a helix at the neck of newly forming synaptic vesicles to cut it free into the cell a process called endocytosis. There are three dynamin genes: dynI (neuron specific), dynII (ubiquitously expressed) and dynIII (low levels in neurons and testes) and dynII mutations cause Charcot-Marie Tooth neurodegeneration, the muscle disease Centronuclear Myopathy and childhood leukaemia.

Phil and his team have made many discoveries about the molecular mechanisms of endocytosis at the synapse. His work revealed that synaptic vesicle endocytosis is a highly regulated process in neurons, triggered by protein dephosphorylation. He uses mass spectrometry for phosphoproteomics to identify all phosphosites in all endocytic proteins and to rank them by abundance and physiological relevance. By working together with the Medicinal Chemist, Adam McCluskey, at the University of Newcastle they have utilised the new knowledge to develop potential new drugs. This represents part of an overall strategy to develop dynamin and endocytosis inhibitors: a) as tools for medical researchers to solve significant biological problems, and b) as potential candidate therapeutics for human disease indications in which harnessing endocytosis pathways may alleviate disease symptoms for epilepsy, cancer, infectious diseases and chronic kidney disease.

Selected grants

2015

  • Ultra high performance liquid chromatography (UPLC) system; Liddle C, Byrne J, George J, Robinson P, Gunton J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Phosphatase regulators mediate long-term changes in presynaptic terminals; Graham M, Robinson P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • High content screening (HCS) in-cell imaging system; Robinson P, Chircop (nee Fabbro) M, Reddel R, Bryan T, Cesare A; DVC Research/Equipment Grant.

2014

  • WAVE 20/50 Bioreactor and C5 Cell Disruptor; Chircop (nee Fabbro) M, Kizana E, Robinson P, Diefenbach R, Bryan T, Gottlieb D, Micklethwaite K, Alexander I; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Molecular mechanisms of dynamin-mediated endocytosis in nerve terminals; Robinson P; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Phosphorylation of synaptic vesicle glycoprotein 2 (SV2) regulates endocytosis of synaptotagmin for synaptic transmission; Robinson P, Graham M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Fluidigm BioMark HD - HX; Alexander I, Jamieson R, Chircop (nee Fabbro) M, Byrne J, Catchpoole D, Reddel R, Tam P, Robinson P, Bryan T, Diefenbach R; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • A Pilot Study of Pre-synaptic Protein Kinases; Graham M, Robinson P; DVC Research/Bridging Support Grant.
  • Molecular dissection of the functional regions of ACTN2 and ACTN3 and their contribution to normal variation in skeletal muscle function; Robinson P, North K, Quinlan (nee Edwards) K; Australian Research Council (ARC)/Discovery Projects (DP).
  • The role of clathrin in the spindle assembly checkpoint and as an anti-cancer target; Chircop (nee Fabbro) M, Robinson P, McCluskey A, Sakoff J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanism of action of dynamin ring stabilizer compounds controlling the actin cytoskeleton; Robinson P, McCluskey A; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Identification of the phospho-regulated synaptic vesicle endocytosis machinery; Graham M, Robinson P; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Sulfonadyn-based dynamin I-specific inhibitors and epilepsy; Robinson P, McCluskey A; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Role of dynamin in modes of synaptic vesicle endocytosis; Robinson P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inhibition of Dynamin II (DynII) as a HIV therapeutic and microbicide strategy; Turville S, Cunningham A, Robinson P; Australian Centre for Hepatitis and HIV Virology Research (ACH2)/Research Support.
  • Beyond Proteomics:structure and function of protein modifications; Robinson P; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • Development of Dynamin Inhibitors as novel therapies for epilepsy; Robinson P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms of synaptic vesicle endocytosis revealed by its regulatory phosphoproteome; Robinson P, Graham M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • O-GlcNAc-phosphorylation: a novel post-translational modification regulating vesicle recycling.; Graham M, Robinson P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Deltavision (DV) Core Image Restoration; Cunningham A, Turville S, Clarke C, Henderson B, Kefford R, North K, O'Neill G, Murray R, Reddel R, Tam P, Robinson P, Chircop M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Endocytosis Inhibitors; Robinson P, Luo L, Haucke V; Group of Eight/Germany Joint Research Co-operation Scheme.

2007

  • Confocal microscope for cancer research in the northern hub; Robinson P, Gunning P, Hardeman E, Henderson B, Bendall L, Chircop (nee Fabbro) M; Cancer Institute New South Wales/Research Grant.

2006

  • How defective dynamin 2activity causes Charcot-Tooth Disease; McCluskey A, Robinson P, Nicholson G; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Ral-mediated signalling pathways in neurons; Robinson P, Roufogalis B; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Daniel, J., Robinson, P. (2014). Rapid analysis of synaptic vesicle endocytosis in synaptosomes. In Peter Thorn (Eds.), Exocytosis Methods, (pp. 167-189). New York: Humana Press. [More Information]
  • Robinson, P., Anggono, V., Cousin, M. (2008). Styryl Dye-Based Synaptic Vesicle Recycling Assay in Cultured Cerebellar Granule Neurons. In A. Vancura (Eds.), Methods in Molecular Biology 457: Membrane Trafficking, (pp. 333-345). New Jersey: Humana Press. [More Information]

Journals

  • Stahlschmidt, W., Robertson, M., Robinson, P., McCluskey, A., Haucke, V. (2014). Clathrin Terminal Domain-Ligand Interactions Regulate Sorting of Mannose 6-Phosphate Receptors Mediated by AP-1 and GGA Adaptors. Journal of Biological Chemistry, 289(8), 4906-4918. [More Information]
  • MacGregor, K., Robertson, M., Young, K., Von Kleist, L., Stahlschmidt, W., Whiting, A., Chau, N., Robinson, P., Haucke, V., McCluskey, A. (2014). Development of 1,8-Naphthalimides as Clathrin Inhibitors. Journal of Medicinal Chemistry, 57, 131-143. [More Information]
  • MacGregor, K., Abdel-Hamid, M., Odell, L., Chau, N., Whiting, A., Robinson, P., McCluskey, A. (2014). Development of quinone analogues as dynamin GTPase inhibitors. European Journal of Medicinal Chemistry, 85, 191-206. [More Information]
  • Myers, S., Malladi, C., Hyland, R., Bautista, T., Boadle, R., Robinson, P., Nicholson, G. (2014). Mutations in the SPTLC1 Protein Cause Mitochondrial Structural Abnormalities and Endoplasmic Reticulum Stress in Lymphoblasts. DNA and Cell Biology, 33(7), 399-407. [More Information]
  • Quan, A., Robinson, P. (2014). Repurposing molecular mechanisms of transmitter release: a new job for syndapin at the fusion pore. Focus on "Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells". American Journal of Physiology: Cell Physiology, 306(9), C792-C793. [More Information]
  • Robertson, M., Deane, F., Robinson, P., McCluskey, A. (2014). Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase. Nature Protocols, 9(4), 851-870. [More Information]
  • Robertson, M., Deane, F., Stahlschmidt, W., Von Kleist, L., Haucke, V., Robinson, P., McCluskey, A. (2014). Synthesis of the Pitstop family of clathrin inhibitors. Nature Protocols, 9(7-8), 1592-1606. [More Information]
  • McCluskey, A., Daniel, J., Hadzic, G., Chau, N., Clayton, E., Mariana, A., Whiting, A., Gorgani, N., Lloyd, J., Quan, A., Moshkanbaryans, L., Krishnan, S., Perera, S., Chircop (nee Fabbro), M., Robinson, P., et al (2013). Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic (Malden), 14(12), 1272-1289. [More Information]
  • Gordon, C., Venn-Brown, B., Robertson, M., Young, K., Chau, N., Mariana, A., Whiting, A., Chircop (nee Fabbro), M., Robinson, P., McCluskey, A. (2013). Development of second-generation indole-based dynamin GTPase inhibitors. Journal of Medicinal Chemistry, 56(1), 46-59. [More Information]
  • Smith, C., Haucke, V., McCluskey, A., Robinson, P., Chircop (nee Fabbro), M. (2013). Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Molecular Cancer, 12(4), 1-15. [More Information]
  • Anggono, V., Koc-Schmitz, Y., Widagdo, J., Kormann, J., Quan, A., Chen, C., Robinson, P., Choi, S., Linden, D., Plomann, M., et al (2013). PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 110(34), 13976-13981. [More Information]
  • McGeachie, A., Odell, L., Quan, A., Daniel, J., Chau, N., Hill, T., Gorgani, N., Keating, D., Cousin, M., van Dam, E., Whiting, A., Perera, S., Novelle, A., Chircop (nee Fabbro), M., Robinson, P., et al (2013). Pyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin Inhibitors. ACS Chemical Biology, 8(7), 1507-1518. [More Information]
  • Ma, M., Robinson, P., Chircop (nee Fabbro), M. (2013). Sorting Nexin 9 Recruits Clathrin Heavy Chain to the Mitotic Spindle for Chromosome Alignment and Segregation. PloS One, 8(7), 1-11. [More Information]
  • Quan, A., Robinson, P. (2013). Syndapin - a membrane remodelling and endocytic F-BAR protein. The FEBS Journal, 280(21), 5198-5212. [More Information]
  • Harper, C., Popoff, M., McCluskey, A., Robinson, P., Meunier, F. (2013). Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors. Trends in Cell Biology, 23(2), 90-101. [More Information]
  • Nguyen, T., Maucort, G., Sullivan, R., Schenning, M., Lavidis, N., McCluskey, A., Robinson, P., Meunier, F. (2012). Actin- and Dynamin-Dependent Maturation of Bulk Endocytosis Restores Neurotransmission following Synaptic Depletion. PloS One, 7(5), 1-15. [More Information]
  • Daniel, J., Malladi, C., Kettle, E., McCluskey, A., Robinson, P. (2012). Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening. Nature Protocols, 7(8), 1439-1455. [More Information]
  • Luwor, R., Chin, X., McCheachie, A., Robinson, P., Zhu, H. (2012). Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation. Growth Factors, 30(4), 220-229. [More Information]
  • Reid, A., Lord, T., Stanger, S., Roman, S., McCluskey, A., Robinson, P., Aitken, R., Nixon, B. (2012). Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa. Journal of Biological Chemistry, 287(45), 37659-37672. [More Information]
  • Brymora, A., Duggin, I., Berven, L., Van Dam, E., Roufogalis, B., Robinson, P. (2012). Identification and Characterisation of the RalA-ERp57 Interaction: Evidence for GDI Activity of ERp57. PloS One, 7(11), 1-11. [More Information]
  • Smith, C., Bensing, S., Burns, C., Robinson, P., Kasperlik-Zaluska, A., Scott, R., Kampe, O., Crock, P. (2012). Identification of TPIT and other novel autoantigens in lymphocytic hypophysitis: immunoscreening of a pituitary cDNA library and development of immunoprecipitation assays. European Journal of Endocrinology, 166(3), 391-398. [More Information]
  • Bolderson, E., Savage, K., Mahen, R., Pisupati, V., Graham, M., Richard, D., Robinson, P., Venkitaraman, A., Khanna, K. (2012). Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1B (HP1-B) mobilization and DNA repair in heterochromatin. Journal of Biological Chemistry, 287(33), 28122-28131. [More Information]
  • Quan, A., Xue, J., Wielens, J., Smillie, K., Anggono, V., Parker, M., Cousin, M., Graham, M., Robinson, P. (2012). Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 109(10), 3760-3765. [More Information]
  • Graham, M., Stone, R., Robinson, P., Payne, R. (2012). Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked beta-N-acetylglucosaminyl-6-phosphate modification. Organic and Biomolecular Chemistry, 10(13), 2545-2551. [More Information]
  • Robertson, M., Hadzic, G., Ambrus, J., Pome, Y., Hyde, E., Whiting, A., Mariana, A., Von Kleist, L., Chau, N., Haucke, V., Robinson, P., et al (2012). The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. A C S Medicinal Chemistry Letters, 3(3), 5-352. [More Information]
  • Graham, M., Thaysen-Andersen, M., Bache, N., Craft, G., Larsen, M., Packer, N., Robinson, P. (2011). A Novel Post-translational Modification in Nerve Terminals: O-Linked N-Acetylglucosamine Phosphorylation. Journal of Proteome Research, 10(6), 2725-2733. [More Information]
  • Kozlov, S., Graham, M., Jakob, B., Tobias, F., Kijas, A., Tanuji, M., Chen, P., Robinson, P., Taucher-Scholz, G., Suzuki, K., et al (2011). Autophosphorylation and ATM activation: additional sites add to the complexity. Journal of Biological Chemistry, 286(11), 9107-9119. [More Information]
  • Xue, J., Graham, M., Novelle, A., Sue, N., Gray, N., McNiven, M., Smillie, K., Cousin, M., Robinson, P. (2011). Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis. Journal of Biological Chemistry, 286(35), 30295-30303. [More Information]
  • Harper, C., Martin, S., Nguyen, T., Daniels, S., Lavidis, N., Popoff, M., Hadzic, G., Mariana, A., Chau, N., McCluskey, A., Robinson, P., et al (2011). Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism. Journal of Biological Chemistry, 286(41), 35966-35976. [More Information]
  • Joshi, S., Braithwaite, A., Robinson, P., Chircop (nee Fabbro), M. (2011). Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression. Molecular Cancer, 10(78), 1-12. [More Information]
  • Nguyen, M., Joya, J., Kee, A., Domazetovska, A., Yang, N., Hook, J., Lemckert, F., Kettle, E., Valova, V., Robinson, P., North, K., et al (2011). Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy. Brain: a journal of neurology, 134(Pt12), 3516-3529. [More Information]
  • Chircop (nee Fabbro), M., Perera, S., Mariana, A., Lau, H., Ma, M., Gilbert, J., Jones, N., Gordon, C., Young, K., Morokoff, A., Robinson, P., et al (2011). Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Molecular Cancer Therapeutics, 10(9), 1553-1562. [More Information]
  • Chircop (nee Fabbro), M., Sarcevic, B., Larsen, M., Malladi, C., Chau, N., Zavortink, M., Smith, C., Quan, A., Anggono, V., Hains, P., Graham, M., Robinson, P. (2011). Phosphorylation of dynamin II at serine-764 is associated with cytokinesis. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1813 (10), 1689-1699. [More Information]
  • Woolley, A., Algie, M., Samuel, W., Harfoot, R., Wiles, A., Hung, N., Tan, P., Hains, P., Valova, V., Huschtscha-Holliday, L., Cohen, S., Robinson, P., Braithwaite, A., et al (2011). Prognostic Association of YB-1 Expression in Breast Cancers: A Matter of Antibody. PloS One, 6(6), Article number e20603-1-Article number e20603-13. [More Information]
  • Von Kleist, L., Stahlschmidt, W., Bulut, H., Gromova, K., Puchkov, D., Robertson, M., Kylie, M., MacGregor, K., Tomilin, N., et al, Chau, N., Chircop (nee Fabbro), M., Robinson, P. (2011). Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition. Cell, 146(3), 471-484. [More Information]
  • Sandgren, K., Wilkinson, J., Miranda Saksena, M., McInerney, G., Byth, K., Robinson, P., Cunningham, A. (2010). A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells. PLoS Pathogens, 6(4), e1000866-1-e1000866-16. [More Information]
  • Chircop (nee Fabbro), M., Malladi, C., Lian, A., Page, S., Zavortink, M., Gordon, C., McCluskey, A., Robinson, P. (2010). Calcineurin activity is required for the completion of cytokinesis. Cellular and Molecular Life Sciences, 67(21), 3725-3737. [More Information]
  • Howes, M., Kirkham, M., Riches, J., Cortese, K., Walser, P., Simpson, F., Hill, M., Jones, A., Lundmark, R., Lindsay, M., Robinson, P., et al (2010). Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. The Journal of Cell Biology, 190(4), 675-691. [More Information]
  • Chan, L., Hansra, G., Robinson, P., Graham, M. (2010). Differential Phosphorylation of Dynamin I Isoforms in Subcellular Compartments Demonstrates the Hidden Complexity of Phosphoproteomes. Journal of Proteome Research, 9(8), 4028-4037. [More Information]
  • Clayton, E., Sue, N., Smillie, K., O'Leary, T., Bache, N., Cheung, G., Cole, A., Wyllie, D., Sutherland, C., Robinson, P., et al (2010). Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles. Nature Neuroscience, 13(7), 845-851. [More Information]
  • Susman, R., Quijano-Roy, S., Yang, N., Webster, R., Clarke, N., Dowling, J., Kennerson, M., Nicholson, G., Biancalana, V., Ilkovski, B., Vucic, S., North, K., et al (2010). Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy. Neuromuscular Disorders, 20(4), 229-237. [More Information]
  • Cohen, S., Wa, W., Valova, V., Algie, M., Harfoot, R., Woolley, A., Robinson, P., Braithwaite, A. (2010). Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing. Oncogene, 29(3), 403-410. [More Information]
  • Hill, T., Mariana, A., Gordon, C., Odell, L., Robertson, M., McGeachie, A., Chau, N., Daniel, J., Gorgani, N., Robinson, P., et al (2010). Iminochromene Inhibitors of Dynamins I and II GTPase Activity and Endocytosis. Journal of Medicinal Chemistry, 53(10), 4094-4102. [More Information]
  • Baker, M., Smith, N., Hetherington, L., Taubman, K., Graham, M., Robinson, P., Aitken, R. (2010). Label-Free Quantitation of Phosphopeptide Changes During Rat Sperm Capacitation. Journal of Proteome Research, 9(2), 718-729. [More Information]
  • Gray, L., Dean, B., Kronsbein, H., Robinson, P., Scarr, E. (2010). Region and diagnosis-specific changes in synaptic proteins in schizophrenia and bipolar I disorder. Psychiatry Research, 178(2), 374-380. [More Information]
  • Joshi, S., Perera, S., Gilbert, J., Smith, C., Mariana, A., Gordon, C., Sarkoff, J., McCluskey, A., Robinson, P., Braithwaite, A., Chircop (nee Fabbro), M. (2010). The Dynamin Inhibitors MiTMAB and OcTMAB Induce Cytokinesis Failure and Inhibit Cell Proliferation in Human Cancer Cells. Molecular Cancer Therapeutics, 9(7), 1995-2006. [More Information]
  • Odell, L., Howan, D., Gordon, C., Robertson, M., Chau, N., Mariana, A., Whiting, A., Abagyan, R., Daniel, J., Gorgani, N., Robinson, P., et al (2010). The Pthaladyns: GTP Competitive Inhibitors of Dynamin I and II GTPase Derived from Virtual Screening. Journal of Medicinal Chemistry, 53, 5267-5280.
  • Odell, L., Chau, N., Mariana, A., Graham, M., Robinson, P., McCluskey, A. (2009). Azido and Diazarinyl Analogues of Bis-Tyrphostin as Asymmetrical Inhibitors of Dynamin GTPase. ChemMedChem: chemistry enabling drug discovery, 4(7), 1182-1188.
  • Hill, T., Gordon, C., McGeachie, A., Venn-Brown, B., Odell, L., Chau, N., Quan, A., Mariana, A., Sakoff, J., Chircop (nee Fabbro), M., Robinson, P., et al (2009). Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. Journal of Medicinal Chemistry, 52(12), 3762-73. [More Information]
  • Kidd, T., Ramsay, K., Hu, H., Bye, P., Elkins, M., Grimwood, K., Harbour, C., Marks, G., Nissen, M., Robinson, P., Rose, B., et al (2009). Low rates of Pseudomonas aeruginosa misidentification in isolates from cystic fibrosis patients. Journal of Clinical Microbiology, 47(5), 1503-1509. [More Information]
  • Kidd, T., Marks, G., Bye, P., Wainwright, C., Robinson, P., Rose, B., Harbour, C., Bell, S. (2009). Multi-centre research in Australia: analysis of a recent National Health and Medical Research Council-funded project. Respirology, 14(7), 1051-1055. [More Information]
  • Veldhuis, N., Valova, V., Gaeth, A., Palstra, N., Hannan, K., Michell, B., Kelly, L., Jennings, I., Kemp, B., Pearson, R., Robinson, P., et al (2009). Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase. The International Journal of Biochemistry and Cell Biology, 41(12), 2403-2412. [More Information]
  • Holland, I., McCluskey, A., Sakoff, J., Gilbert, J., Chau, N., Robinson, P., Motti, C., Wright, A., van Altena, I. (2009). Steroids from an Australian Sponge Psammoclema sp. Journal of Natural Products, 72(1), 102-106. [More Information]
  • Chircop (nee Fabbro), M., Oakes, V., Graham, M., Ma, M., Smith, C., Robinson, P., Khanna, K. (2009). The actin-binding and bundling protein, EPLIN, is required for cytokinesis. Cell Cycle, 8(5), 757-764. [More Information]
  • Clayton, E., Anggono, V., Smillie, K., Chau, N., Robinson, P., Cousin, M. (2009). The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. The Journal of Neuroscience, 29(24), 7706-7717. [More Information]
  • Dunkley, P., Jarvie, P., Robinson, P. (2008). A rapid Percoll gradient procedure for preparation of synaptosomes. Nature Protocols, 3(11), 1718-1728. [More Information]
  • Robinson, P., Waters, K. (2008). Are children just small adults? The differences between paediatric and adult sleep medicine. Internal Medicine Journal, 38(9), 719-731. [More Information]
  • Zhang, J., Lawrance, G., Chau, N., Robinson, P., McCluskey, A. (2008). From Spanish fly to room-temperature ionic liquids (RTILs): synthesis, thermal stability and inhibition of dynamin 1 GTPase by a novel class of RTILs. New Journal of Chemistry, 32(1), 28-36.
  • Thingholm, T., Jensen, O., Robinson, P., Larsen, M. (2008). SIMAC (sequential elution from IMAC), a phosphoproteomics strategy for the rapid separation of monophosphorylated from multiply phosphorylated peptides. Molecular and Cellular Proteomics, 7(4), 661-671.
  • Tsang, C., Fedchyshyn, M., Harrison, J., Xie, H., Xue, J., Robinson, P., Wang, L., Trimble, W. (2008). Superfluous Role of Mammalian Septins 3 and 5 in Neuronal Development and Synaptic Transmission. Molecular and Cellular Biology, 28(23), 7012-7029. [More Information]
  • Craft, G., Graham, M., Bache, N., Larsen, M., Robinson, P. (2008). The in vivo phosphorylation sites in multiple isoforms of amphiphysin I from rat brain nerve terminals. Molecular and Cellular Proteomics, 7(6), 1146-1161. [More Information]
  • Robinson, P., Fitzgerald, D. (2007). Congenital diaphragmatic hernia. Paediatric Respiratory Reviews, 8(4), 323-335. [More Information]
  • Domazetovska, A., Ilkovski, B., Kumar, V., Valova, V., Vandebrouck, A., Hutchinson, D., Robinson, P., Cooper, S., Sparrow, J., Peckham, M., North, K. (2007). Intranuclear rod myopathy: molecular pathogenesis and mechanisms of weakness. Annals of Neurology, 62(6), 597-608. [More Information]
  • Quan, A., McGeachie, A., Keating, D., Van Dam, E., Rusak, J., Chau, N., Malladi, C., Chen, C., McCluskey, A., Cousin, M., Robinson, P. (2007). Myristyl Trimethyl Ammonium Bromide and Octadecyl Trimethyl Ammonium Bromide Are Surface-Active Small Molecule Dynamin Inhibitors that Block Endocytosis Mediated by Dynamin I or Dynamin II. Molecular Pharmacology, 72(6), 1425-1439. [More Information]
  • Robinson, P. (2007). Neuroscience. How to fill a synapse. Science, 316(5824), 551-553. [More Information]
  • Cohen, S., Graham, M., Lovrecz, G., Bache, N., Robinson, P., Reddel, R. (2007). Protein composition of catalytically active human telomerase from immortal cells. Science, 315(5820), 1850-1853. [More Information]
  • Anggono, V., Robinson, P. (2007). Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Journal of Neurochemistry, 102(3), 931-943. [More Information]
  • Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007). Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry, 46(40), 11279-11290. [More Information]
  • Graham, M., Kilby, D., Firth, S., Robinson, P., Baxter, R. (2007). The in vivo phosphorylation and glycosylation of human insulin-like growth factor binding protein-5. Molecular and Cellular Proteomics, 6(8), 1392-1405. [More Information]
  • Graham, M., Anggono, V., Bache, N., Larsen, M., Craft, G., Robinson, P. (2007). The in vivo phosphorylation sites of rat brain dynamin I. Journal of Biological Chemistry, 282(20), 14695-14707. [More Information]
  • Clarke, N., Ilkovski, B., Cooper, S., Valova, V., Robinson, P., Nonaka, I., Feng, J., Marston, S., North, K. (2007). The pathogenesis of ACTA1-related congenital fiber type disproportion. Annals of Neurology, 61(6), 552-561. [More Information]
  • Acevedo, K., Li, R., Soo, P., Suryadinata, R., Sarcevic, B., Valova, V., Graham, M., Robinson, P., Bernard, O. (2007). The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Experimental Cell Research: emphasizing molecular approaches to cell biology, 313(20), 4091-4106. [More Information]
  • Fu, D., van Dam, E., Brymora, A., Duggin, I., Robinson, P., Roufogalis, B. (2007). The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1773 (7), 1062-1072. [More Information]
  • Hilliard, L., Osicka, T., Clavant, S., Robinson, P., Nikolic-Paterson, D., Comper, W. (2006). Characterization of the urinary albumin degradation pathway in the isolated perfused rat kidney. Translational Research: the journal of laboratory and clinical medicine, 147(1), 36-44.
  • Shipman, K., Robinson, P., King, B., Smith, R., Nicholson, R. (2006). Identification of a family of DNA-binding proteins with homology to RNA splicing factors. Biochemistry and Cell Biology-Biochimie et Biologie Cellulaire, 84(1), 9-19.
  • Kozlov, S., Graham, M., Peng, C., Chen, P., Robinson, P., Lavin, M. (2006). Involvement of novel autophosphorylation sites in ATM activation. The EMBO Journal, 25(15), 3504-3514.
  • Van Dam, E., Robinson, P. (2006). Ral: Mediator of membrane trafficking. The International Journal of Biochemistry and Cell Biology, 38(11), 1841-1847. [More Information]
  • Anggono, V., Smillie, K., Graham, M., Valova, V., Cousin, M., Robinson, P. (2006). Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nature Neuroscience, 9(6), 752-760. [More Information]
  • Domazetovska, A., Ilkovski, B., Cooper, S., Valova, V., Lemckert, F., Hook, J., Hardeman, E., Robinson, P., Yang, N., Gunning, P., North, K. (2006). Unravelling the thin filament: mechanisms of weakness in inherited muscle disease. Neuromuscular Disorders, 16(Sup. 1), S60-S61.
  • Chircop (nee Fabbro), M., Zhou, B., Takahashi, M., Sarcevic, B., Lal, P., Graham, M., Gabrielli, B., Robinson, P., Nigg, E., Ono, Y., et al (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental Cell, 9(4), 477-488. [More Information]
  • Hill, T., Sakoff, J., Robinson, P., McCluskey, A. (2005). Parallel Solution-Phase Synthesis of Targeted Tyrphostin Libraries with Anticancer Activity. Australian Journal of Chemistry: an international journal for chemical science, 58(2), 94-103.
  • Quan, A., Robinson, P. (2005). Rapid purification of native dynamin I and colorimetric GTPase assay. Methods in Enzymology, 404, 556-569. [More Information]
  • Hill, T., Odell, L., Edwards, J., Graham, M., McGeachie, A., Rusak, J., Quan, A., Abagyan, R., Scott, J., Robinson, P., et al (2005). Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins. Journal of Medicinal Chemistry, 48(24), 7781-7788.
  • Dubin, M., Stokes, P., Sum, E., Williams, R., Valova, V., Robinson, P., Lindeman, G., Glover, J., Visvader, J., Matthews, J. (2004). Dimerization Of CtIP, A BRCA1- And CtBP-Interacting Protein, Is Mediated By An N-Terminal Coiled-Coil Motif. Journal of Biological Chemistry, 279(26), 26932-26938.
  • Larsen, M., Graham, M., Robinson, P., Roepstorff, P. (2004). Improved Detection Of Hydrophilic Phosphopeptides Using Graphite Powder Microcolumns And Mass Spectrometry: Evidence For In Vivo Doubly Phosphorylated Dynamin I And Dynamin Iii. Molecular and Cellular Proteomics, 3(5), 456-465.
  • Hill, T., Odell, L., Quan, A., Abagyan, R., Ferguson, G., Robinson, P., McCluskey, A. (2004). Long Chain Amines And Long Chain Ammonium Salts As Novel Inhibitors Of Dynamin Gtpase Activity. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 14(12), 3275-3278. [More Information]
  • Graham, M., Ruma-Haynes, P., Capes-Davis, A., Dunn, J., Tan, T., Valova, V., Robinson, P., Jeffrey, P. (2004). Multisite Phosphorylation Of Doublecortin By Cyclin-Dependent Kinase 5. Biochemical Journal, 381(2), 471-481.
  • Fudge, E., Falkov, A., Kowalenko, N., Robinson, P. (2004). Parenting is a mental health issue. Australasian Psychiatry, 12(2), 166-171.
  • Xue, J., Milburn, P., Hanna, B., Graham, M., Rostas, J., Robinson, P. (2004). Phosphorylation Of Septin 3 On Ser-91 By Cgmp-Dependent Protein Kinase-I In Nerve Terminals. Biochemical Journal, 381(3), 753-760.
  • Xue, J., Tsang, C., Gai, W., Malladi, C., Trimble, W., Rostas, J., Robinson, P. (2004). Septin 3 (G-Septin) Is A Developmentally Regulated Phosphoprotein Enriched In Presynaptic Nerve Terminals. Journal of Neurochemistry, 91(3), 579-590.
  • Tan, T., Valova, V., Malladi, C., Graham, M., Berven, L., Jupp, O., Hansra, G., McClure, S., Sarcevic, B., Boadle, R., Robinson, P., et al (2003). Cdk5 is essential for synaptic vesicle endocytosis. Nature Cell Biology, 5(8), 701-710.
  • Cousin, M., Malladi, C., Tan, T., Raymond, C., Smillie, K., Robinson, P. (2003). Synapsin I-associated Phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool. Journal of Biological Chemistry, 278(31), 29065-29071.
  • Garvin, S., McAllister, S., Robinson, P. (2002). A national initiative: Children of parents with a mental illness. Youth Studies Australia, 21(2), 17-22.
  • Scarr, E., Pavey, G., Robinson, P., Opeskin, D., Copolov, D., Dean, B. (2002). Decreased phorbol ester binding in the parahippocampal gyrus from subjects with schizophrenia is not associated with changes in protein kinase C. Molecular Psychiatry, 7(7), 683-688.
  • McCluskey, A., Robinson, P., Hill, T., Scott, J., Edwards, J. (2002). Green chemistry approaches to the knoevenagel condensation: comparison of ethanol, water and solvent free (dry grind) approaced. Tetrahedron Letters, 43(17), 3117-3120.
  • O'Dwyer, D., Smith, A., Matthew, M., Andronicos, N., Ranson, M., Robinson, P., Crock, P. (2002). Identification of the 49-kDa autoantigen associated with lymphocytic hypophsitis as beta-enolase. Journal of Clinical Endocrinology and Metabolism, 87(2), 752-757.
  • Robinson, P., Harrison-Findik, D., Misra, S., Jain, S., Keeler,, M., Powell, K., Malladi, C., Varticovski, L. (2001). Dynamin inhibits phosphatidylinositol 3-kinase in hematopoietic cells. BBA - Bioenergetics, 1538, 10-19.
  • Brymora, A., Cousin,, M., Roufogalis, B., Robinson, P. (2001). Enhanced Protein Recovery and Reproducibility from Pull-Down Assays and Immunoprecipitations using spin columns. Analytical Biochemistry, 295(1), 119-122.
  • Robinson, P., Tan, T., Cousin,, M. (2001). Protein phosphorylation is required to endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but no AP180 or amphiphysin. Journal of Neurochemistry, 76, 105-116.
  • Brymora, A., Roufogalis, B., Robinson, P., Valova, V., Larsen, M. (2001). The brain exocyst complex interacts with RalA in a GTP-dependent manner - Identification of a novel mammalian Sec3 gene and a second Sec15 gene. Journal of Biological Chemistry, 276(32), 29792-29797.
  • Robinson, P., Cousin, M. (2001). The Dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis. Trends in Neurosciences, 24, 659-665.

2014

  • Stahlschmidt, W., Robertson, M., Robinson, P., McCluskey, A., Haucke, V. (2014). Clathrin Terminal Domain-Ligand Interactions Regulate Sorting of Mannose 6-Phosphate Receptors Mediated by AP-1 and GGA Adaptors. Journal of Biological Chemistry, 289(8), 4906-4918. [More Information]
  • MacGregor, K., Robertson, M., Young, K., Von Kleist, L., Stahlschmidt, W., Whiting, A., Chau, N., Robinson, P., Haucke, V., McCluskey, A. (2014). Development of 1,8-Naphthalimides as Clathrin Inhibitors. Journal of Medicinal Chemistry, 57, 131-143. [More Information]
  • MacGregor, K., Abdel-Hamid, M., Odell, L., Chau, N., Whiting, A., Robinson, P., McCluskey, A. (2014). Development of quinone analogues as dynamin GTPase inhibitors. European Journal of Medicinal Chemistry, 85, 191-206. [More Information]
  • Myers, S., Malladi, C., Hyland, R., Bautista, T., Boadle, R., Robinson, P., Nicholson, G. (2014). Mutations in the SPTLC1 Protein Cause Mitochondrial Structural Abnormalities and Endoplasmic Reticulum Stress in Lymphoblasts. DNA and Cell Biology, 33(7), 399-407. [More Information]
  • Daniel, J., Robinson, P. (2014). Rapid analysis of synaptic vesicle endocytosis in synaptosomes. In Peter Thorn (Eds.), Exocytosis Methods, (pp. 167-189). New York: Humana Press. [More Information]
  • Quan, A., Robinson, P. (2014). Repurposing molecular mechanisms of transmitter release: a new job for syndapin at the fusion pore. Focus on "Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells". American Journal of Physiology: Cell Physiology, 306(9), C792-C793. [More Information]
  • Robertson, M., Deane, F., Robinson, P., McCluskey, A. (2014). Synthesis of Dynole 34-2, Dynole 2-24 and Dyngo 4a for investigating dynamin GTPase. Nature Protocols, 9(4), 851-870. [More Information]
  • Robertson, M., Deane, F., Stahlschmidt, W., Von Kleist, L., Haucke, V., Robinson, P., McCluskey, A. (2014). Synthesis of the Pitstop family of clathrin inhibitors. Nature Protocols, 9(7-8), 1592-1606. [More Information]

2013

  • McCluskey, A., Daniel, J., Hadzic, G., Chau, N., Clayton, E., Mariana, A., Whiting, A., Gorgani, N., Lloyd, J., Quan, A., Moshkanbaryans, L., Krishnan, S., Perera, S., Chircop (nee Fabbro), M., Robinson, P., et al (2013). Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic (Malden), 14(12), 1272-1289. [More Information]
  • Gordon, C., Venn-Brown, B., Robertson, M., Young, K., Chau, N., Mariana, A., Whiting, A., Chircop (nee Fabbro), M., Robinson, P., McCluskey, A. (2013). Development of second-generation indole-based dynamin GTPase inhibitors. Journal of Medicinal Chemistry, 56(1), 46-59. [More Information]
  • Smith, C., Haucke, V., McCluskey, A., Robinson, P., Chircop (nee Fabbro), M. (2013). Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Molecular Cancer, 12(4), 1-15. [More Information]
  • Anggono, V., Koc-Schmitz, Y., Widagdo, J., Kormann, J., Quan, A., Chen, C., Robinson, P., Choi, S., Linden, D., Plomann, M., et al (2013). PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 110(34), 13976-13981. [More Information]
  • McGeachie, A., Odell, L., Quan, A., Daniel, J., Chau, N., Hill, T., Gorgani, N., Keating, D., Cousin, M., van Dam, E., Whiting, A., Perera, S., Novelle, A., Chircop (nee Fabbro), M., Robinson, P., et al (2013). Pyrimidyn Compounds: Dual-Action Small Molecule Pyrimidine-Based Dynamin Inhibitors. ACS Chemical Biology, 8(7), 1507-1518. [More Information]
  • Ma, M., Robinson, P., Chircop (nee Fabbro), M. (2013). Sorting Nexin 9 Recruits Clathrin Heavy Chain to the Mitotic Spindle for Chromosome Alignment and Segregation. PloS One, 8(7), 1-11. [More Information]
  • Quan, A., Robinson, P. (2013). Syndapin - a membrane remodelling and endocytic F-BAR protein. The FEBS Journal, 280(21), 5198-5212. [More Information]
  • Harper, C., Popoff, M., McCluskey, A., Robinson, P., Meunier, F. (2013). Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors. Trends in Cell Biology, 23(2), 90-101. [More Information]

2012

  • Nguyen, T., Maucort, G., Sullivan, R., Schenning, M., Lavidis, N., McCluskey, A., Robinson, P., Meunier, F. (2012). Actin- and Dynamin-Dependent Maturation of Bulk Endocytosis Restores Neurotransmission following Synaptic Depletion. PloS One, 7(5), 1-15. [More Information]
  • Daniel, J., Malladi, C., Kettle, E., McCluskey, A., Robinson, P. (2012). Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening. Nature Protocols, 7(8), 1439-1455. [More Information]
  • Luwor, R., Chin, X., McCheachie, A., Robinson, P., Zhu, H. (2012). Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation. Growth Factors, 30(4), 220-229. [More Information]
  • Reid, A., Lord, T., Stanger, S., Roman, S., McCluskey, A., Robinson, P., Aitken, R., Nixon, B. (2012). Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa. Journal of Biological Chemistry, 287(45), 37659-37672. [More Information]
  • Brymora, A., Duggin, I., Berven, L., Van Dam, E., Roufogalis, B., Robinson, P. (2012). Identification and Characterisation of the RalA-ERp57 Interaction: Evidence for GDI Activity of ERp57. PloS One, 7(11), 1-11. [More Information]
  • Smith, C., Bensing, S., Burns, C., Robinson, P., Kasperlik-Zaluska, A., Scott, R., Kampe, O., Crock, P. (2012). Identification of TPIT and other novel autoantigens in lymphocytic hypophysitis: immunoscreening of a pituitary cDNA library and development of immunoprecipitation assays. European Journal of Endocrinology, 166(3), 391-398. [More Information]
  • Bolderson, E., Savage, K., Mahen, R., Pisupati, V., Graham, M., Richard, D., Robinson, P., Venkitaraman, A., Khanna, K. (2012). Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1B (HP1-B) mobilization and DNA repair in heterochromatin. Journal of Biological Chemistry, 287(33), 28122-28131. [More Information]
  • Quan, A., Xue, J., Wielens, J., Smillie, K., Anggono, V., Parker, M., Cousin, M., Graham, M., Robinson, P. (2012). Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 109(10), 3760-3765. [More Information]
  • Graham, M., Stone, R., Robinson, P., Payne, R. (2012). Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked beta-N-acetylglucosaminyl-6-phosphate modification. Organic and Biomolecular Chemistry, 10(13), 2545-2551. [More Information]
  • Robertson, M., Hadzic, G., Ambrus, J., Pome, Y., Hyde, E., Whiting, A., Mariana, A., Von Kleist, L., Chau, N., Haucke, V., Robinson, P., et al (2012). The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. A C S Medicinal Chemistry Letters, 3(3), 5-352. [More Information]

2011

  • Graham, M., Thaysen-Andersen, M., Bache, N., Craft, G., Larsen, M., Packer, N., Robinson, P. (2011). A Novel Post-translational Modification in Nerve Terminals: O-Linked N-Acetylglucosamine Phosphorylation. Journal of Proteome Research, 10(6), 2725-2733. [More Information]
  • Kozlov, S., Graham, M., Jakob, B., Tobias, F., Kijas, A., Tanuji, M., Chen, P., Robinson, P., Taucher-Scholz, G., Suzuki, K., et al (2011). Autophosphorylation and ATM activation: additional sites add to the complexity. Journal of Biological Chemistry, 286(11), 9107-9119. [More Information]
  • Xue, J., Graham, M., Novelle, A., Sue, N., Gray, N., McNiven, M., Smillie, K., Cousin, M., Robinson, P. (2011). Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis. Journal of Biological Chemistry, 286(35), 30295-30303. [More Information]
  • Harper, C., Martin, S., Nguyen, T., Daniels, S., Lavidis, N., Popoff, M., Hadzic, G., Mariana, A., Chau, N., McCluskey, A., Robinson, P., et al (2011). Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism. Journal of Biological Chemistry, 286(41), 35966-35976. [More Information]
  • Joshi, S., Braithwaite, A., Robinson, P., Chircop (nee Fabbro), M. (2011). Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression. Molecular Cancer, 10(78), 1-12. [More Information]
  • Nguyen, M., Joya, J., Kee, A., Domazetovska, A., Yang, N., Hook, J., Lemckert, F., Kettle, E., Valova, V., Robinson, P., North, K., et al (2011). Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy. Brain: a journal of neurology, 134(Pt12), 3516-3529. [More Information]
  • Chircop (nee Fabbro), M., Perera, S., Mariana, A., Lau, H., Ma, M., Gilbert, J., Jones, N., Gordon, C., Young, K., Morokoff, A., Robinson, P., et al (2011). Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Molecular Cancer Therapeutics, 10(9), 1553-1562. [More Information]
  • Chircop (nee Fabbro), M., Sarcevic, B., Larsen, M., Malladi, C., Chau, N., Zavortink, M., Smith, C., Quan, A., Anggono, V., Hains, P., Graham, M., Robinson, P. (2011). Phosphorylation of dynamin II at serine-764 is associated with cytokinesis. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1813 (10), 1689-1699. [More Information]
  • Woolley, A., Algie, M., Samuel, W., Harfoot, R., Wiles, A., Hung, N., Tan, P., Hains, P., Valova, V., Huschtscha-Holliday, L., Cohen, S., Robinson, P., Braithwaite, A., et al (2011). Prognostic Association of YB-1 Expression in Breast Cancers: A Matter of Antibody. PloS One, 6(6), Article number e20603-1-Article number e20603-13. [More Information]
  • Von Kleist, L., Stahlschmidt, W., Bulut, H., Gromova, K., Puchkov, D., Robertson, M., Kylie, M., MacGregor, K., Tomilin, N., et al, Chau, N., Chircop (nee Fabbro), M., Robinson, P. (2011). Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition. Cell, 146(3), 471-484. [More Information]

2010

  • Sandgren, K., Wilkinson, J., Miranda Saksena, M., McInerney, G., Byth, K., Robinson, P., Cunningham, A. (2010). A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells. PLoS Pathogens, 6(4), e1000866-1-e1000866-16. [More Information]
  • Chircop (nee Fabbro), M., Malladi, C., Lian, A., Page, S., Zavortink, M., Gordon, C., McCluskey, A., Robinson, P. (2010). Calcineurin activity is required for the completion of cytokinesis. Cellular and Molecular Life Sciences, 67(21), 3725-3737. [More Information]
  • Howes, M., Kirkham, M., Riches, J., Cortese, K., Walser, P., Simpson, F., Hill, M., Jones, A., Lundmark, R., Lindsay, M., Robinson, P., et al (2010). Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. The Journal of Cell Biology, 190(4), 675-691. [More Information]
  • Chan, L., Hansra, G., Robinson, P., Graham, M. (2010). Differential Phosphorylation of Dynamin I Isoforms in Subcellular Compartments Demonstrates the Hidden Complexity of Phosphoproteomes. Journal of Proteome Research, 9(8), 4028-4037. [More Information]
  • Clayton, E., Sue, N., Smillie, K., O'Leary, T., Bache, N., Cheung, G., Cole, A., Wyllie, D., Sutherland, C., Robinson, P., et al (2010). Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles. Nature Neuroscience, 13(7), 845-851. [More Information]
  • Susman, R., Quijano-Roy, S., Yang, N., Webster, R., Clarke, N., Dowling, J., Kennerson, M., Nicholson, G., Biancalana, V., Ilkovski, B., Vucic, S., North, K., et al (2010). Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy. Neuromuscular Disorders, 20(4), 229-237. [More Information]
  • Cohen, S., Wa, W., Valova, V., Algie, M., Harfoot, R., Woolley, A., Robinson, P., Braithwaite, A. (2010). Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing. Oncogene, 29(3), 403-410. [More Information]
  • Hill, T., Mariana, A., Gordon, C., Odell, L., Robertson, M., McGeachie, A., Chau, N., Daniel, J., Gorgani, N., Robinson, P., et al (2010). Iminochromene Inhibitors of Dynamins I and II GTPase Activity and Endocytosis. Journal of Medicinal Chemistry, 53(10), 4094-4102. [More Information]
  • Baker, M., Smith, N., Hetherington, L., Taubman, K., Graham, M., Robinson, P., Aitken, R. (2010). Label-Free Quantitation of Phosphopeptide Changes During Rat Sperm Capacitation. Journal of Proteome Research, 9(2), 718-729. [More Information]
  • Gray, L., Dean, B., Kronsbein, H., Robinson, P., Scarr, E. (2010). Region and diagnosis-specific changes in synaptic proteins in schizophrenia and bipolar I disorder. Psychiatry Research, 178(2), 374-380. [More Information]
  • Joshi, S., Perera, S., Gilbert, J., Smith, C., Mariana, A., Gordon, C., Sarkoff, J., McCluskey, A., Robinson, P., Braithwaite, A., Chircop (nee Fabbro), M. (2010). The Dynamin Inhibitors MiTMAB and OcTMAB Induce Cytokinesis Failure and Inhibit Cell Proliferation in Human Cancer Cells. Molecular Cancer Therapeutics, 9(7), 1995-2006. [More Information]
  • Odell, L., Howan, D., Gordon, C., Robertson, M., Chau, N., Mariana, A., Whiting, A., Abagyan, R., Daniel, J., Gorgani, N., Robinson, P., et al (2010). The Pthaladyns: GTP Competitive Inhibitors of Dynamin I and II GTPase Derived from Virtual Screening. Journal of Medicinal Chemistry, 53, 5267-5280.

2009

  • Odell, L., Chau, N., Mariana, A., Graham, M., Robinson, P., McCluskey, A. (2009). Azido and Diazarinyl Analogues of Bis-Tyrphostin as Asymmetrical Inhibitors of Dynamin GTPase. ChemMedChem: chemistry enabling drug discovery, 4(7), 1182-1188.
  • Hill, T., Gordon, C., McGeachie, A., Venn-Brown, B., Odell, L., Chau, N., Quan, A., Mariana, A., Sakoff, J., Chircop (nee Fabbro), M., Robinson, P., et al (2009). Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. Journal of Medicinal Chemistry, 52(12), 3762-73. [More Information]
  • Kidd, T., Ramsay, K., Hu, H., Bye, P., Elkins, M., Grimwood, K., Harbour, C., Marks, G., Nissen, M., Robinson, P., Rose, B., et al (2009). Low rates of Pseudomonas aeruginosa misidentification in isolates from cystic fibrosis patients. Journal of Clinical Microbiology, 47(5), 1503-1509. [More Information]
  • Kidd, T., Marks, G., Bye, P., Wainwright, C., Robinson, P., Rose, B., Harbour, C., Bell, S. (2009). Multi-centre research in Australia: analysis of a recent National Health and Medical Research Council-funded project. Respirology, 14(7), 1051-1055. [More Information]
  • Veldhuis, N., Valova, V., Gaeth, A., Palstra, N., Hannan, K., Michell, B., Kelly, L., Jennings, I., Kemp, B., Pearson, R., Robinson, P., et al (2009). Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase. The International Journal of Biochemistry and Cell Biology, 41(12), 2403-2412. [More Information]
  • Holland, I., McCluskey, A., Sakoff, J., Gilbert, J., Chau, N., Robinson, P., Motti, C., Wright, A., van Altena, I. (2009). Steroids from an Australian Sponge Psammoclema sp. Journal of Natural Products, 72(1), 102-106. [More Information]
  • Chircop (nee Fabbro), M., Oakes, V., Graham, M., Ma, M., Smith, C., Robinson, P., Khanna, K. (2009). The actin-binding and bundling protein, EPLIN, is required for cytokinesis. Cell Cycle, 8(5), 757-764. [More Information]
  • Clayton, E., Anggono, V., Smillie, K., Chau, N., Robinson, P., Cousin, M. (2009). The phospho-dependent dynamin-syndapin interaction triggers activity-dependent bulk endocytosis of synaptic vesicles. The Journal of Neuroscience, 29(24), 7706-7717. [More Information]

2008

  • Dunkley, P., Jarvie, P., Robinson, P. (2008). A rapid Percoll gradient procedure for preparation of synaptosomes. Nature Protocols, 3(11), 1718-1728. [More Information]
  • Robinson, P., Waters, K. (2008). Are children just small adults? The differences between paediatric and adult sleep medicine. Internal Medicine Journal, 38(9), 719-731. [More Information]
  • Zhang, J., Lawrance, G., Chau, N., Robinson, P., McCluskey, A. (2008). From Spanish fly to room-temperature ionic liquids (RTILs): synthesis, thermal stability and inhibition of dynamin 1 GTPase by a novel class of RTILs. New Journal of Chemistry, 32(1), 28-36.
  • Thingholm, T., Jensen, O., Robinson, P., Larsen, M. (2008). SIMAC (sequential elution from IMAC), a phosphoproteomics strategy for the rapid separation of monophosphorylated from multiply phosphorylated peptides. Molecular and Cellular Proteomics, 7(4), 661-671.
  • Robinson, P., Anggono, V., Cousin, M. (2008). Styryl Dye-Based Synaptic Vesicle Recycling Assay in Cultured Cerebellar Granule Neurons. In A. Vancura (Eds.), Methods in Molecular Biology 457: Membrane Trafficking, (pp. 333-345). New Jersey: Humana Press. [More Information]
  • Tsang, C., Fedchyshyn, M., Harrison, J., Xie, H., Xue, J., Robinson, P., Wang, L., Trimble, W. (2008). Superfluous Role of Mammalian Septins 3 and 5 in Neuronal Development and Synaptic Transmission. Molecular and Cellular Biology, 28(23), 7012-7029. [More Information]
  • Craft, G., Graham, M., Bache, N., Larsen, M., Robinson, P. (2008). The in vivo phosphorylation sites in multiple isoforms of amphiphysin I from rat brain nerve terminals. Molecular and Cellular Proteomics, 7(6), 1146-1161. [More Information]

2007

  • Robinson, P., Fitzgerald, D. (2007). Congenital diaphragmatic hernia. Paediatric Respiratory Reviews, 8(4), 323-335. [More Information]
  • Domazetovska, A., Ilkovski, B., Kumar, V., Valova, V., Vandebrouck, A., Hutchinson, D., Robinson, P., Cooper, S., Sparrow, J., Peckham, M., North, K. (2007). Intranuclear rod myopathy: molecular pathogenesis and mechanisms of weakness. Annals of Neurology, 62(6), 597-608. [More Information]
  • Quan, A., McGeachie, A., Keating, D., Van Dam, E., Rusak, J., Chau, N., Malladi, C., Chen, C., McCluskey, A., Cousin, M., Robinson, P. (2007). Myristyl Trimethyl Ammonium Bromide and Octadecyl Trimethyl Ammonium Bromide Are Surface-Active Small Molecule Dynamin Inhibitors that Block Endocytosis Mediated by Dynamin I or Dynamin II. Molecular Pharmacology, 72(6), 1425-1439. [More Information]
  • Robinson, P. (2007). Neuroscience. How to fill a synapse. Science, 316(5824), 551-553. [More Information]
  • Cohen, S., Graham, M., Lovrecz, G., Bache, N., Robinson, P., Reddel, R. (2007). Protein composition of catalytically active human telomerase from immortal cells. Science, 315(5820), 1850-1853. [More Information]
  • Anggono, V., Robinson, P. (2007). Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. Journal of Neurochemistry, 102(3), 931-943. [More Information]
  • Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007). Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry, 46(40), 11279-11290. [More Information]
  • Graham, M., Kilby, D., Firth, S., Robinson, P., Baxter, R. (2007). The in vivo phosphorylation and glycosylation of human insulin-like growth factor binding protein-5. Molecular and Cellular Proteomics, 6(8), 1392-1405. [More Information]
  • Graham, M., Anggono, V., Bache, N., Larsen, M., Craft, G., Robinson, P. (2007). The in vivo phosphorylation sites of rat brain dynamin I. Journal of Biological Chemistry, 282(20), 14695-14707. [More Information]
  • Clarke, N., Ilkovski, B., Cooper, S., Valova, V., Robinson, P., Nonaka, I., Feng, J., Marston, S., North, K. (2007). The pathogenesis of ACTA1-related congenital fiber type disproportion. Annals of Neurology, 61(6), 552-561. [More Information]
  • Acevedo, K., Li, R., Soo, P., Suryadinata, R., Sarcevic, B., Valova, V., Graham, M., Robinson, P., Bernard, O. (2007). The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Experimental Cell Research: emphasizing molecular approaches to cell biology, 313(20), 4091-4106. [More Information]
  • Fu, D., van Dam, E., Brymora, A., Duggin, I., Robinson, P., Roufogalis, B. (2007). The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein. BBA: Biochimica et Biophysica Acta - Molecular Cell Research, 1773 (7), 1062-1072. [More Information]

2006

  • Hilliard, L., Osicka, T., Clavant, S., Robinson, P., Nikolic-Paterson, D., Comper, W. (2006). Characterization of the urinary albumin degradation pathway in the isolated perfused rat kidney. Translational Research: the journal of laboratory and clinical medicine, 147(1), 36-44.
  • Shipman, K., Robinson, P., King, B., Smith, R., Nicholson, R. (2006). Identification of a family of DNA-binding proteins with homology to RNA splicing factors. Biochemistry and Cell Biology-Biochimie et Biologie Cellulaire, 84(1), 9-19.
  • Kozlov, S., Graham, M., Peng, C., Chen, P., Robinson, P., Lavin, M. (2006). Involvement of novel autophosphorylation sites in ATM activation. The EMBO Journal, 25(15), 3504-3514.
  • Van Dam, E., Robinson, P. (2006). Ral: Mediator of membrane trafficking. The International Journal of Biochemistry and Cell Biology, 38(11), 1841-1847. [More Information]
  • Anggono, V., Smillie, K., Graham, M., Valova, V., Cousin, M., Robinson, P. (2006). Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nature Neuroscience, 9(6), 752-760. [More Information]
  • Domazetovska, A., Ilkovski, B., Cooper, S., Valova, V., Lemckert, F., Hook, J., Hardeman, E., Robinson, P., Yang, N., Gunning, P., North, K. (2006). Unravelling the thin filament: mechanisms of weakness in inherited muscle disease. Neuromuscular Disorders, 16(Sup. 1), S60-S61.

2005

  • Chircop (nee Fabbro), M., Zhou, B., Takahashi, M., Sarcevic, B., Lal, P., Graham, M., Gabrielli, B., Robinson, P., Nigg, E., Ono, Y., et al (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental Cell, 9(4), 477-488. [More Information]
  • Hill, T., Sakoff, J., Robinson, P., McCluskey, A. (2005). Parallel Solution-Phase Synthesis of Targeted Tyrphostin Libraries with Anticancer Activity. Australian Journal of Chemistry: an international journal for chemical science, 58(2), 94-103.
  • Quan, A., Robinson, P. (2005). Rapid purification of native dynamin I and colorimetric GTPase assay. Methods in Enzymology, 404, 556-569. [More Information]
  • Hill, T., Odell, L., Edwards, J., Graham, M., McGeachie, A., Rusak, J., Quan, A., Abagyan, R., Scott, J., Robinson, P., et al (2005). Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins. Journal of Medicinal Chemistry, 48(24), 7781-7788.

2004

  • Dubin, M., Stokes, P., Sum, E., Williams, R., Valova, V., Robinson, P., Lindeman, G., Glover, J., Visvader, J., Matthews, J. (2004). Dimerization Of CtIP, A BRCA1- And CtBP-Interacting Protein, Is Mediated By An N-Terminal Coiled-Coil Motif. Journal of Biological Chemistry, 279(26), 26932-26938.
  • Larsen, M., Graham, M., Robinson, P., Roepstorff, P. (2004). Improved Detection Of Hydrophilic Phosphopeptides Using Graphite Powder Microcolumns And Mass Spectrometry: Evidence For In Vivo Doubly Phosphorylated Dynamin I And Dynamin Iii. Molecular and Cellular Proteomics, 3(5), 456-465.
  • Hill, T., Odell, L., Quan, A., Abagyan, R., Ferguson, G., Robinson, P., McCluskey, A. (2004). Long Chain Amines And Long Chain Ammonium Salts As Novel Inhibitors Of Dynamin Gtpase Activity. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 14(12), 3275-3278. [More Information]
  • Graham, M., Ruma-Haynes, P., Capes-Davis, A., Dunn, J., Tan, T., Valova, V., Robinson, P., Jeffrey, P. (2004). Multisite Phosphorylation Of Doublecortin By Cyclin-Dependent Kinase 5. Biochemical Journal, 381(2), 471-481.
  • Fudge, E., Falkov, A., Kowalenko, N., Robinson, P. (2004). Parenting is a mental health issue. Australasian Psychiatry, 12(2), 166-171.
  • Xue, J., Milburn, P., Hanna, B., Graham, M., Rostas, J., Robinson, P. (2004). Phosphorylation Of Septin 3 On Ser-91 By Cgmp-Dependent Protein Kinase-I In Nerve Terminals. Biochemical Journal, 381(3), 753-760.
  • Xue, J., Tsang, C., Gai, W., Malladi, C., Trimble, W., Rostas, J., Robinson, P. (2004). Septin 3 (G-Septin) Is A Developmentally Regulated Phosphoprotein Enriched In Presynaptic Nerve Terminals. Journal of Neurochemistry, 91(3), 579-590.

2003

  • Tan, T., Valova, V., Malladi, C., Graham, M., Berven, L., Jupp, O., Hansra, G., McClure, S., Sarcevic, B., Boadle, R., Robinson, P., et al (2003). Cdk5 is essential for synaptic vesicle endocytosis. Nature Cell Biology, 5(8), 701-710.
  • Cousin, M., Malladi, C., Tan, T., Raymond, C., Smillie, K., Robinson, P. (2003). Synapsin I-associated Phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool. Journal of Biological Chemistry, 278(31), 29065-29071.

2002

  • Garvin, S., McAllister, S., Robinson, P. (2002). A national initiative: Children of parents with a mental illness. Youth Studies Australia, 21(2), 17-22.
  • Scarr, E., Pavey, G., Robinson, P., Opeskin, D., Copolov, D., Dean, B. (2002). Decreased phorbol ester binding in the parahippocampal gyrus from subjects with schizophrenia is not associated with changes in protein kinase C. Molecular Psychiatry, 7(7), 683-688.
  • McCluskey, A., Robinson, P., Hill, T., Scott, J., Edwards, J. (2002). Green chemistry approaches to the knoevenagel condensation: comparison of ethanol, water and solvent free (dry grind) approaced. Tetrahedron Letters, 43(17), 3117-3120.
  • O'Dwyer, D., Smith, A., Matthew, M., Andronicos, N., Ranson, M., Robinson, P., Crock, P. (2002). Identification of the 49-kDa autoantigen associated with lymphocytic hypophsitis as beta-enolase. Journal of Clinical Endocrinology and Metabolism, 87(2), 752-757.

2001

  • Robinson, P., Harrison-Findik, D., Misra, S., Jain, S., Keeler,, M., Powell, K., Malladi, C., Varticovski, L. (2001). Dynamin inhibits phosphatidylinositol 3-kinase in hematopoietic cells. BBA - Bioenergetics, 1538, 10-19.
  • Brymora, A., Cousin,, M., Roufogalis, B., Robinson, P. (2001). Enhanced Protein Recovery and Reproducibility from Pull-Down Assays and Immunoprecipitations using spin columns. Analytical Biochemistry, 295(1), 119-122.
  • Robinson, P., Tan, T., Cousin,, M. (2001). Protein phosphorylation is required to endocytosis in nerve terminals: potential role for the dephosphins dynamin I and synaptojanin, but no AP180 or amphiphysin. Journal of Neurochemistry, 76, 105-116.
  • Brymora, A., Roufogalis, B., Robinson, P., Valova, V., Larsen, M. (2001). The brain exocyst complex interacts with RalA in a GTP-dependent manner - Identification of a novel mammalian Sec3 gene and a second Sec15 gene. Journal of Biological Chemistry, 276(32), 29792-29797.
  • Robinson, P., Cousin, M. (2001). The Dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis. Trends in Neurosciences, 24, 659-665.

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