Emeritus Professor Laurence Mather

Emeritus Professor
Anaesthesia, Northern Clinical School
Kolling Institute of Medical Research

Telephone +61 2 9926 8420
Fax +61 2 9906 4079

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Selected grants

2005

  • Pharmacological Consequences Of General Anaesthesia On Local Anaesthetic Cardiotoxicity; Mather L; ANZ Coll Anaesthetists (ANZCA)/Research Funding Scheme.

2004

  • Northern Sydney Health research staff; Tennant C, Mather L, Cousins M; North Sydney Area Health Board/Contributions to Research Staff.

2003

  • Northern Sydney Health research staff; Tennant C, Mather L, Cousins M; North Sydney Area Health Board/Contributions to Research Staff.

2000

  • Pain relief for the living and the dying; Cousins M, Mather L, Harris R; National Health and Medical Research Council (NHMRC)/Centre of Clinical Research Excellence.
  • Novel methods of quantifying pain and inflammation to assess efficacy of over-the-counter medications; Gelgor L, Benrimoj S, Mather L, Dwarte D; Australian Research Council (ARC)/Strategic Partnerships with Industry - Research and Training (SPIRT).
  • How hypersensitivity to pain is produced and how it is influenced by aspirin-like drugs; Mather L; Govt Employees Medical Research Fund/Research Grant.
  • NSAIDs - a PK-PD study of differential actions and activity at relevant anatomical sites; Mather L, Power I, Cousins M; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Mather, L., Tucker, G. (2009). Properties, absorption and disposition of local anesthetics. Neural Blockade in Clinical Anesthesia and Pain Medicine. 4th Ed, (pp. 45-91). United States of America: Lippincott Williams & Wilkins.
  • Mather, L. (2007). Postoperative pain, local anaesthetics. In Schmidt RR, Willis WD (eds.); Sjölund BH et al. (field eds.): (Eds.), Encyclopedia of Pain, (pp. 1896-1901). Heidelberg: Springer.

Journals

  • Mather, L., Rauwendaal, E., Moxham-Hall, V., Wodak, A. (2013). (Re)introducing medicinal cannabis. Medical Journal of Australia, 199(11), 759-761. [More Information]
  • Mather, L. (2010). The acute toxicity of local anesthetics. Expert Opinion on Drug Metabolism and Toxicology, 6(11), 1313-1332. [More Information]
  • Parker, D., Coolican, M., Mather, L., Graham, D., DeWall, M. (2009). Safety of Combined Use of Local Anesthetic Infiltration and Reinfusion Drains in Total Knee Arthroplasty. Journal of Arthroplasty, 24(6), 918-924. [More Information]
  • Copeland, S., Ladd, L., Gu, X., Mather, L. (2008). The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. Anesthesia and Analgesia, 106(5), 1429-1439. [More Information]
  • Copeland, S., Ladd, L., Gu, X., Mather, L. (2008). The effects of general anesthesia on whole body and regional pharmacokinetics of local anesthetics at toxic doses. Anesthesia and Analgesia, 106(5), 1440-1449. [More Information]
  • Murphy, S., Boyle, F., Davey, R., Gu, X., Mather, L. (2007). Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU. Journal of Pharmacy and Pharmacology, 59(1), 105-114. [More Information]
  • Murphy, S., Davey, R., Gu, X., Haywood, M., McCann, L., Mather, L., Boyle, F. (2007). Enhancement of cisplatin efficacy by thalidomide in a 9L rat gliosarcoma model. Journal of Neuro-Oncology, 85(2), 181-189. [More Information]
  • Edwards, S., Mather, L., Smith, M. (2007). Studies with ketamine and alfentanil following Freund''s complete adjuvant-induced inflammation in rats. Clinical and Experimental Pharmacology and Physiology, 34(5), 414-420.
  • Murphy, S., Boyle, F., Gu, X., Mather, L. (2006). Thalidomide enantiomers: determination in biological samples by HPLC and vancomycin-CSP. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 831, 48-56. [More Information]
  • Mather, L., Copeland, S., Ladd, L. (2005). Acute toxicity of local anesthetics: underlying pharmacokinetic and pharmacodynamic concepts. Regional Anesthesia and Pain Medicine, 30(6), 553-566. [More Information]
  • Mather, L. (2005). Cannabinoid pharmacotherapy: past, present and future. Minerva anestesiologica, 71, 405-12. [More Information]
  • Mather, L. (2005). Individual responder analyses for pain: does one dose fit all? Trends In Pharmacological Sciences, 26(11), 544-5. [More Information]
  • McElduff, A., Mather, L., Kam, P., Clauson, P. (2005). Influence of acute upper respiratory tract infection on the absorption of inhaled insulin using the AERx insulin Diabetes Management System. British Journal of Clinical Pharmacology, 59(5), 546-551. [More Information]
  • Costello, T., Cormack, J., Mather, L., LaFerlita, B., Murphy, M., Harris, K. (2005). Plasma levobupivacaine concentrations following scalp block in patients undergoing awake craniotomy. British Journal of Anaesthesia, 94(6), 848-851. [More Information]
  • Mather, L. (2005). Stereochemistry in anaesthetic and analgetic drugs. Minerva anestesiologica, 71(9), 507-16. [More Information]
  • Ladd, L., Kam, P., Williams, D., Wright, A., Smith, M., Mather, L. (2005). Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions. British Journal of Clinical Pharmacology, 59(5), 524-535. [More Information]
  • Mather, L., Duke, C., Ladd, L., Copeland, S., Gallagher, G., Chang, D. (2004). Direct Cardiac Effects Of Coronary Site-Directed Thiopental And Its Enantiomers - A Comparison To Propofol In Conscious Sheep. Anesthesiology, 101(2), 354-364.
  • Mather, L., Ladd, L., Copeland, S., Chang, D. (2004). Effects Of Imposed Acid-Base Derangement On The Cardiovascular Effects And Pharmacokinetics Of Bupivacaine And Thiopental. Anesthesiology, 100(6), 1457-1468.
  • Edwards, S., Mather, L. (2003). Alfentanil potentiates anaesthetic and electroencephalographic responses to ketamine in the rat. European Journal of Pharmacology, 460(1), 27-35.
  • Cordato, D., Herkes, G., Mather, L., Morgan, M. (2003). Barbiturates for acute neurological and neurosurgical emergencies – do they still have a role? Journal of Clinical Neuroscience, 10(3), 283-288.
  • Edwards, S., Mather, L. (2003). Diclofenac increases the accumulation of kynurenate following trytophan pretreatment in the rat: a possible factor contributing to its antihyperalgesic effect. Inflammopharmacology, 11(3), 277-292.
  • Ladd, L., Copeland, S., Mather, L. (2003). Neurally-mediated cardiotoxicity of local anesthetics: direct effect of seizures or of local anesthetics?:In reply:-. Anesthesiology, 11, 1296-1297.
  • Cordato, D., Mather, L., Herkes, G. (2003). Stereochemistry in clinical medicine: a neurological perspective. Journal of Clinical Neuroscience, 10(6), 649-654. [More Information]
  • Mather, L., Cousins, M. (2003). The site of action of epidural fentanyl: What can be learned by studying the difference between infusion and bolus administration? The Importance of history, one hopes. Anesthesia and Analgesia, 11, 1211-1213.
  • Fryirs, B., Mather, L., Dawson, M., Kelly, T., Keegan, J. (2002). A Rapid and Sensitive High-Performance Liquid Chromatography-Electrospray Ionization-Triple Quadrupole Mass Spectrometry Method for the Quantitation of Oxycodone in Human Plasma. Journal of Chromatographic Science, 40(1), 40-44.
  • Edwards, S., Minto, C., Mather, L. (2002). Concurrent ketamine and alfentanil administration: pharmacokinetic considerations. British Journal of Anaesthesia, 88(1), 94-100.
  • Ladd, L., Chang, D., Wilson, K., Copeland, S., Plummer, J., Mather, L. (2002). Effects of CNS Site-directed Carotid Arterial Infusions of Bupivacaine, Levobupivacaine, and Ropivacaine in Sheep. Anesthesiology, 97(2), 418-428.
  • Barratt, S., Smith, R., Kee, A., Mather, L., Cousins, M. (2002). Multimodal Analgesia and Intravenous Nutrition Preserves Total Body Protein Following Major Upper Gastrointestinal Surgery. Regional Anesthesia and Pain Medicine, 27(1), 15-22.
  • Mather, L. (2001). Anatomical-physiological approaches in pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 40, 707-722.
  • Mather, L., Chang, D. (2001). Cardiotoxicity with modern local anaesthetics. Drugs, 61, 333-342.
  • Mather, L., Chang, D., Ladd, L., Copeland, S., Iglesias,, M., Plummer, J. (2001). Direct cardiac effects of intracoronary bupivacaine, levobupivacine and ropivacaine in the sheep. British Journal of Pharmacology, 132, 649-658.
  • Grace, R., Edwards, S., Power, I., Mather, L., Lin,, Y. (2001). Effects of diclofenac in the rat tail ischaemia-reperfusion injury model of acute hyperalgesia. Pain, 89, 117-125.
  • Vickers, E., Goebel, C., Mather, L., Mackay, L., Wells, R. (2001). High performance liquid chromatographic determination of bradykinin in saliva: a critical review and a new method. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 755, 101-110.
  • Mather, L., Wright, S., Smith, M. (2001). Hydromorphone-3-glucoronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sciences, 69, 409-420.
  • Mather, L. (2001). Medicinal cannabis - hoax or hope? Regional Anesthesia and Pain Medicine, 26, 484-487.
  • Cordato, D., Herkes, G., Mather, L., Morgan, M., Gross, A., Finfer, S. (2001). Prolonged thiopentone infusion for neurosurgical emergencies: usefulness of therapeutic drug monitoring. Anaesthesia and Intensive Care, 29, 339-348.
  • Mather, L., South, S., Wright, S., Smith, M., Lau,, M. (2001). Sex related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance. Journal of Pharmacology and Experimental Therapeutics, 297, 446-457.
  • Mather, L., Coates, K., Johnson, R., Flood, P. (2001). Thiopental is a competitive inhibitor at the human alpha7 nicotinic acetycholine receptor. Anesthesia and Analgesia, 92, 930-933.
  • Edwards, S., Mather, L. (2001). Tissue uptake of ketamine and noketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion. Life Sciences, 69, 2051-2066.
  • Siddall, P., Molloy, A., Walker, S., Mather, L., Rutkowski, S., Cousins, M. (2000). The Efficacy of Intrathecal Morphine and Clonidine in the Treatment of Pain After Spinal Cord Injury. Anesthesia and Analgesia, 91(6), 1493-1498.

Conferences

  • Tague, G., Loftus, S., Devonshire, E., Siddall, P., Taylor, I., Cousins, M., Mather, L., Nicholas, M. (2006). International Collaboration in Graduate Pain Management Education. Pain Across the Lifespan: The 26th Annual Scientific Meeting of the Australian Pain Society, unkown.

2013

  • Mather, L., Rauwendaal, E., Moxham-Hall, V., Wodak, A. (2013). (Re)introducing medicinal cannabis. Medical Journal of Australia, 199(11), 759-761. [More Information]

2010

  • Mather, L. (2010). The acute toxicity of local anesthetics. Expert Opinion on Drug Metabolism and Toxicology, 6(11), 1313-1332. [More Information]

2009

  • Mather, L., Tucker, G. (2009). Properties, absorption and disposition of local anesthetics. Neural Blockade in Clinical Anesthesia and Pain Medicine. 4th Ed, (pp. 45-91). United States of America: Lippincott Williams & Wilkins.
  • Parker, D., Coolican, M., Mather, L., Graham, D., DeWall, M. (2009). Safety of Combined Use of Local Anesthetic Infiltration and Reinfusion Drains in Total Knee Arthroplasty. Journal of Arthroplasty, 24(6), 918-924. [More Information]

2008

  • Copeland, S., Ladd, L., Gu, X., Mather, L. (2008). The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. Anesthesia and Analgesia, 106(5), 1429-1439. [More Information]
  • Copeland, S., Ladd, L., Gu, X., Mather, L. (2008). The effects of general anesthesia on whole body and regional pharmacokinetics of local anesthetics at toxic doses. Anesthesia and Analgesia, 106(5), 1440-1449. [More Information]

2007

  • Murphy, S., Boyle, F., Davey, R., Gu, X., Mather, L. (2007). Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU. Journal of Pharmacy and Pharmacology, 59(1), 105-114. [More Information]
  • Murphy, S., Davey, R., Gu, X., Haywood, M., McCann, L., Mather, L., Boyle, F. (2007). Enhancement of cisplatin efficacy by thalidomide in a 9L rat gliosarcoma model. Journal of Neuro-Oncology, 85(2), 181-189. [More Information]
  • Mather, L. (2007). Postoperative pain, local anaesthetics. In Schmidt RR, Willis WD (eds.); Sjölund BH et al. (field eds.): (Eds.), Encyclopedia of Pain, (pp. 1896-1901). Heidelberg: Springer.
  • Edwards, S., Mather, L., Smith, M. (2007). Studies with ketamine and alfentanil following Freund''s complete adjuvant-induced inflammation in rats. Clinical and Experimental Pharmacology and Physiology, 34(5), 414-420.

2006

  • Tague, G., Loftus, S., Devonshire, E., Siddall, P., Taylor, I., Cousins, M., Mather, L., Nicholas, M. (2006). International Collaboration in Graduate Pain Management Education. Pain Across the Lifespan: The 26th Annual Scientific Meeting of the Australian Pain Society, unkown.
  • Murphy, S., Boyle, F., Gu, X., Mather, L. (2006). Thalidomide enantiomers: determination in biological samples by HPLC and vancomycin-CSP. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 831, 48-56. [More Information]

2005

  • Mather, L., Copeland, S., Ladd, L. (2005). Acute toxicity of local anesthetics: underlying pharmacokinetic and pharmacodynamic concepts. Regional Anesthesia and Pain Medicine, 30(6), 553-566. [More Information]
  • Mather, L. (2005). Cannabinoid pharmacotherapy: past, present and future. Minerva anestesiologica, 71, 405-12. [More Information]
  • Mather, L. (2005). Individual responder analyses for pain: does one dose fit all? Trends In Pharmacological Sciences, 26(11), 544-5. [More Information]
  • McElduff, A., Mather, L., Kam, P., Clauson, P. (2005). Influence of acute upper respiratory tract infection on the absorption of inhaled insulin using the AERx insulin Diabetes Management System. British Journal of Clinical Pharmacology, 59(5), 546-551. [More Information]
  • Costello, T., Cormack, J., Mather, L., LaFerlita, B., Murphy, M., Harris, K. (2005). Plasma levobupivacaine concentrations following scalp block in patients undergoing awake craniotomy. British Journal of Anaesthesia, 94(6), 848-851. [More Information]
  • Mather, L. (2005). Stereochemistry in anaesthetic and analgetic drugs. Minerva anestesiologica, 71(9), 507-16. [More Information]
  • Ladd, L., Kam, P., Williams, D., Wright, A., Smith, M., Mather, L. (2005). Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions. British Journal of Clinical Pharmacology, 59(5), 524-535. [More Information]

2004

  • Mather, L., Duke, C., Ladd, L., Copeland, S., Gallagher, G., Chang, D. (2004). Direct Cardiac Effects Of Coronary Site-Directed Thiopental And Its Enantiomers - A Comparison To Propofol In Conscious Sheep. Anesthesiology, 101(2), 354-364.
  • Mather, L., Ladd, L., Copeland, S., Chang, D. (2004). Effects Of Imposed Acid-Base Derangement On The Cardiovascular Effects And Pharmacokinetics Of Bupivacaine And Thiopental. Anesthesiology, 100(6), 1457-1468.

2003

  • Edwards, S., Mather, L. (2003). Alfentanil potentiates anaesthetic and electroencephalographic responses to ketamine in the rat. European Journal of Pharmacology, 460(1), 27-35.
  • Cordato, D., Herkes, G., Mather, L., Morgan, M. (2003). Barbiturates for acute neurological and neurosurgical emergencies – do they still have a role? Journal of Clinical Neuroscience, 10(3), 283-288.
  • Edwards, S., Mather, L. (2003). Diclofenac increases the accumulation of kynurenate following trytophan pretreatment in the rat: a possible factor contributing to its antihyperalgesic effect. Inflammopharmacology, 11(3), 277-292.
  • Ladd, L., Copeland, S., Mather, L. (2003). Neurally-mediated cardiotoxicity of local anesthetics: direct effect of seizures or of local anesthetics?:In reply:-. Anesthesiology, 11, 1296-1297.
  • Cordato, D., Mather, L., Herkes, G. (2003). Stereochemistry in clinical medicine: a neurological perspective. Journal of Clinical Neuroscience, 10(6), 649-654. [More Information]
  • Mather, L., Cousins, M. (2003). The site of action of epidural fentanyl: What can be learned by studying the difference between infusion and bolus administration? The Importance of history, one hopes. Anesthesia and Analgesia, 11, 1211-1213.

2002

  • Fryirs, B., Mather, L., Dawson, M., Kelly, T., Keegan, J. (2002). A Rapid and Sensitive High-Performance Liquid Chromatography-Electrospray Ionization-Triple Quadrupole Mass Spectrometry Method for the Quantitation of Oxycodone in Human Plasma. Journal of Chromatographic Science, 40(1), 40-44.
  • Edwards, S., Minto, C., Mather, L. (2002). Concurrent ketamine and alfentanil administration: pharmacokinetic considerations. British Journal of Anaesthesia, 88(1), 94-100.
  • Ladd, L., Chang, D., Wilson, K., Copeland, S., Plummer, J., Mather, L. (2002). Effects of CNS Site-directed Carotid Arterial Infusions of Bupivacaine, Levobupivacaine, and Ropivacaine in Sheep. Anesthesiology, 97(2), 418-428.
  • Barratt, S., Smith, R., Kee, A., Mather, L., Cousins, M. (2002). Multimodal Analgesia and Intravenous Nutrition Preserves Total Body Protein Following Major Upper Gastrointestinal Surgery. Regional Anesthesia and Pain Medicine, 27(1), 15-22.

2001

  • Mather, L. (2001). Anatomical-physiological approaches in pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 40, 707-722.
  • Mather, L., Chang, D. (2001). Cardiotoxicity with modern local anaesthetics. Drugs, 61, 333-342.
  • Mather, L., Chang, D., Ladd, L., Copeland, S., Iglesias,, M., Plummer, J. (2001). Direct cardiac effects of intracoronary bupivacaine, levobupivacine and ropivacaine in the sheep. British Journal of Pharmacology, 132, 649-658.
  • Grace, R., Edwards, S., Power, I., Mather, L., Lin,, Y. (2001). Effects of diclofenac in the rat tail ischaemia-reperfusion injury model of acute hyperalgesia. Pain, 89, 117-125.
  • Vickers, E., Goebel, C., Mather, L., Mackay, L., Wells, R. (2001). High performance liquid chromatographic determination of bradykinin in saliva: a critical review and a new method. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 755, 101-110.
  • Mather, L., Wright, S., Smith, M. (2001). Hydromorphone-3-glucoronide: a more potent neuro-excitant than its structural analogue, morphine-3-glucuronide. Life Sciences, 69, 409-420.
  • Mather, L. (2001). Medicinal cannabis - hoax or hope? Regional Anesthesia and Pain Medicine, 26, 484-487.
  • Cordato, D., Herkes, G., Mather, L., Morgan, M., Gross, A., Finfer, S. (2001). Prolonged thiopentone infusion for neurosurgical emergencies: usefulness of therapeutic drug monitoring. Anaesthesia and Intensive Care, 29, 339-348.
  • Mather, L., South, S., Wright, S., Smith, M., Lau,, M. (2001). Sex related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance. Journal of Pharmacology and Experimental Therapeutics, 297, 446-457.
  • Mather, L., Coates, K., Johnson, R., Flood, P. (2001). Thiopental is a competitive inhibitor at the human alpha7 nicotinic acetycholine receptor. Anesthesia and Analgesia, 92, 930-933.
  • Edwards, S., Mather, L. (2001). Tissue uptake of ketamine and noketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion. Life Sciences, 69, 2051-2066.

2000

  • Siddall, P., Molloy, A., Walker, S., Mather, L., Rutkowski, S., Cousins, M. (2000). The Efficacy of Intrathecal Morphine and Clonidine in the Treatment of Pain After Spinal Cord Injury. Anesthesia and Analgesia, 91(6), 1493-1498.

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