Dr Qian (Kevin) Wang

Senior Research Fellow
Origins of Cancer Laboratory, Centenary Institute of Cancer Medicine & Cell Biology, Central Clinical School

Telephone 02 9565 6262

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Biographical details

Dr Wang graduated with a Bachelor degree in the Department of Biophysics and Physiology at Fudan University in 1998. He obtained his PhD from Lens Research Laboratory at the University of Sydney in 2008, under the supervision of Associate Professor Frank Lovicu and Professor John McAvoy. His PhD research examined MAPK and PI3K signalling pathways that involved in lens fibre cell differentiation. His postdoctoral research is supervised by Dr Jeff Holst and Professor John Rasko in the Origins of Cancer Laboratory and Gene and Stem Cell Therapy Program at the Centenary Institute. His study is focussed on the role and regulation of amino acid transporters and their related signalling pathways in prostate cancer.

Research interests

The PI3K/PTEN/Akt pathway is frequently altered in prostate cancer. Up and down-regulation of many members of this pathway, including mTOR, neutral endopeptidase and PTEN, together or separately, are found in most prostate cancers.

Amino acids such as leucine have been shown to activate mTOR thereby contributing to uncontrolled proliferation of prostate cancer cells. The host laboratory's international track record in amino acid regulation will be applied to dissect how transporters including leucine transporters, may promote prostate cancer. This will be studied using prostate cancer cell lines and a prostate cancer mouse model crossed with a new knockout mouse model. Analysis of the genes involved in the onset and progression of prostate cancer will be determined in these models. LAT3 is a potential target for therapeutic intervention, and understanding this complex network may provide new insights into the effect of diet (particularly red meats and dairy which are high in leucine) on the development and progression of prostate cancer.

Teaching and supervision

Honours and Postgraduate Research supervision

International links

France

(YE-LEHMANN, Shixin Chargé de Recherche (CR1,INSERM) Biology Institute, Ecole Normale Supérieure, Paris ) We focused on adapting the site-directed mutagenesis with unnatural amino acids in the study of LAT3

Selected grants

2014

  • Developing novel therapeutics targeting amino acid transport to inhibit metastasis in advanced prostate cancer; Wang K; Prostate Cancer Foundation of Australia/Young Investigator Grants.

Selected publications

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Journals

  • Wang, K., Grkovic, T., Font Sadurni, J., Bonham, S., Pouwer, R., Bailey, C., Moran, A., Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al (2014). Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growt. ACS Chemical Biology, 9(6), 1369-1376. [More Information]
  • Wang, K., Beaumont, K., Otte, N., Font Sadurni, J., Bailey, C., van Geldermalsen, M., Sharp, D., Tiffen, J., Ryan, R., Jormakka, M., Haass, N., Rasko, J., Holst, J. (2014). Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer, 135(5), 1060-1071. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. Journal of the National Cancer Institute, 105(19), 1463-1473. [More Information]
  • Tiffen, J., Bailey, C., Marshall, A., Metierre, C., Feng, Y., Wang, K., Watson, S., Holst, J., Rasko, J. (2013). The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells. International Journal of Cancer, 133(7), 1603-1614. [More Information]

2014

  • Wang, K., Grkovic, T., Font Sadurni, J., Bonham, S., Pouwer, R., Bailey, C., Moran, A., Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al (2014). Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growt. ACS Chemical Biology, 9(6), 1369-1376. [More Information]
  • Wang, K., Beaumont, K., Otte, N., Font Sadurni, J., Bailey, C., van Geldermalsen, M., Sharp, D., Tiffen, J., Ryan, R., Jormakka, M., Haass, N., Rasko, J., Holst, J. (2014). Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer, 135(5), 1060-1071. [More Information]

2013

  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. Journal of the National Cancer Institute, 105(19), 1463-1473. [More Information]
  • Tiffen, J., Bailey, C., Marshall, A., Metierre, C., Feng, Y., Wang, K., Watson, S., Holst, J., Rasko, J. (2013). The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells. International Journal of Cancer, 133(7), 1603-1614. [More Information]

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