People_

Professor Rachel Codd

Professor of Bioinorganic and Medicinal Chemistry
School of Medical Sciences
Molecular Biomedicine Research Theme

Phone

+61 2 9351 6738

Fax

+61 2 9351 3868

rachel.codd@sydney.edu.au

Details

Member of The Centre for Drug Discovery Innovation

Biographical details

BSc (Hons), School of Chemistry, University of Sydney, 1992
PhD, School of Chemistry, University of Sydney, 1998
Postdoctoral Research Associate, School of Biochemistry and Molecular Genetics, University of New South Wales, 1997-1999
Postdoctoral Research Associate, Department of Chemistry, University of Arizona, USA, 1999-2000
Gritton Research Fellow, School of Chemistry, University of Sydney, 2000
Lecturer, School of Chemistry, University of Sydney, 2001
Lecturer, School of Medical Sciences, University of Sydney, 2007
Senior Lecturer, School of Medical Sciences, University of Sydney, 2010
Associate Professor, School of Medical Sciences, University of Sydney, 2013
Professor, School of Medical Sciences, University of Sydney, 2017

Research interests

My research interests and expertise centres on the inorganic chemistry and chemical biology of bacterial metabolites known as siderophores that contain hydroxamic acid functional groups with high affinity towards complexing Fe(III) and other metal ions relevant to biomedicine, and metal recovery. My interdisciplinary research blends chemistry (inorganic, organic, and medicinal), molecular biology and biotechnology. I am internationally renowned for innovations in the design and production of metal binding compounds (termed ‘chelators') for imaging/therapy and/or managing metal dyshomeostasis and/or environmental remediation/recovery. My team has: (i) improved hydroxamic acid syntheses; (ii) produced using Zr(IV)-based metal-templated synthesis two new chelator chemotypes with potential for Zr(IV)-89 immunological positron emission tomography (PET) imaging; (iii) produced new water soluble Zr(IV)-89 chelators using a combined microbiological-semi-synthetic chemistry approach; (iv) invented a first-in-class dual-chelator to enable the development of immunological theranostic agents; and (v) pioneered a chemo-enzymatic approach to deliver biocombinatorial pools of multimeric metal chelators to reveal new Ga(III) and Zr(IV) coordination chemistry. In parallel, my team conducts research on bacterial metabolomes for siderophore discovery and to inform biosynthetic pathways, and the design and production of iron chelators with the aim to expand options to manage transfusion-dependent secondary iron overload disease. Collaborators include: QIMR Berghofer Medical Research Institute, The Department of PET and Nuclear Medicine (RPAH), The University of Melbourne, the Florey Institute of Neuroscience and Mental Health, the Children's Cancer Institute, Australian Nuclear Science and Technology Organisation (ANSTO), Centre for Advanced Imaging, University of Queensland, Telix Pharmaceuticals, University of New South Wales, CSIRO.

Teaching and supervision

I have a major teaching presence into PCOL3012/3912 Drug Design & Development and also teach into MCHM3001/3901 From Molecules to Therapeutics. I am the academic lead for the major in Medicinal Chemistry in the Bachelor of Science and Bachelor of Advanced Studies.

Current projects

Metal-Templated Synthesis of Hydroxamic Acid Macrocycles
Using Bacteria as Biosynthetic Machines to Generate New Siderophores
Immobilised Metal Ion Affinity Chromatography in Drug DIscovery
Design and Production of Chelators with Selectivity for PET Imaging Radiometals
Streamlined Manufacture of Chelators and Technologies for Metal Sequestration or Delivery
Siderophores as Trojan Horse Antibiotics
Exanding the Chemical Space of Chelators Using Chemoenzymatic Production

Awards and honours

Selby Research Award, 2003
Cancer Institute NSW Innovation Award, 2009
Sir Zelman Cowen Universities Fund Prize for Medical Research, 2010
Biota Medal for Medicinal Chemistry, 2010
Semi-Finalist: Elsevier Green and Sustainable Chemistry Challenge, 2015
Sydney Medical School Award for Excellence in Research Supervision, 2015
Editorial Board of the Journal of Inorganic Biochemistry, 2015-
Elected a Fellow of the Royal Australian Chemical Institute (FRACI), 2016
Vice Chancellor's Award for Excellence: Outstanding Teaching and Research, 2016
Appointed to the ARC College of Experts, 2016-2018
Editorial Advisory Board of the Journal of Biological Inorganic Chemistry, 2019-
Associate Editor of the Journal of Inorganic BIochemistry, 2020-2022
Graduate of the Australian Institute of Company Directors (GAICD), 2023
Appointed to the ARC College of Experts, 2025-2027
Elected as a Council Member of the Sociey of Biological Inorganic Chemistry (SBIC), 2024-2028

Themes

Cancer, Infection and Immunological Conditions

Keywords

Pharmacology, Metals in Biology, Chemistry, Imaging Agents and Theranostics, Medicinal Chemistry and Chemical Biology

Approaches

Cellular/Molecular, Chemistry, Spectroscopy

PhD and master's project opportunities

Chemical Biology of Siderophores

Current research students

Project title	Research student
Evaluating and expanding the chemical space of metal chelators	Samuel FEENEY
Enzyme-mediated machining of chelators with tailored metal selectivity	Joseph WANG

Publications

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Book Chapters

Codd, R. (2023). Siderophores and iron transport. In Jan Reedijk & Kenneth R. Poeppelmeier (Eds.), Comprehensive Inorganic Chemistry III, (pp. 3-29). Australia: Elsevier. [More Information]
Codd, R., Gu, J., Ejje, N., Lifa, T. (2014). New Applications of Immobilized Metal Ion Affinity Chromatography in Chemical Biology. In Gilles Gasser (Eds.), Inorganic Chemical Biology: Principles, Techniques and Applications, (pp. 1-35). Chichester: John Wiley & Sons. [More Information]
Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer. [More Information]
Codd, R. (2003). Biomolecules from extremophilic life. In Nicholls, Pailthorpe (Eds.), From Zero to Infinity, (pp. 37-48). Sydney: Science Foundation for Physics.
Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.

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Journals

Wood, J., Ghosh, S., Houston, Z., Fletcher, N., Humphries, J., Mardon, K., Akhter, D., Tieu, W., Ivashkevich, A., Wheatcroft, M., Codd, R., et al (2024). A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements. Chemical Science, 15(30), 11748-11760. [More Information]
Markham, T., Codd, R. (2024). A Mild and Modular Approach to the Total Synthesis of Desferrioxamine B. The Journal of Organic Chemistry, 89(7), 5118-5125. [More Information]
Nolan, K., Rosser, C., Wood, J., Font Sadurni, J., Sresutharsan, A., Wang, J., Markham, T., Ryan, R., Codd, R. (2024). An elastic siderophore synthetase and rubbery substrates assemble multimeric linear and macrocyclic hydroxamic acid metal chelators. Chemical Science. [More Information]
Richardson-Sanchez, T., Telfer, T., Soe, C., Nolan, K., Gotsbacher, M., Codd, R. (2024). The production of siderophore analogues using precursor-directed biosynthesis. Methods in Enzymology, 702, 121-145. [More Information]
Ni, J., Wood, J., White, M., Lihi, N., Markham, T., Wang, J., Chivers, P., Codd, R. (2023). Reduction-cleavable desferrioxamine B pulldown system enriches Ni(ii)-superoxide dismutase from a Streptomyces proteome. RSC Chemical Biology, 4(12), 1064-1072. [More Information]
Ho Shon, I., Hennessy, T., Guille, J., Gotsbacher, M., Lay, A., McBride, B., Codd, R., Hogg, P. (2022). A first-in-human study of [68Ga]Ga-CDI: a positron emitting radiopharmaceutical for imaging tumour cell death. European Journal of Nuclear Medicine and Molecular Imaging, 49(12), 4037-4047. [More Information]
Nolan, K., Font Sadurni, J., Sresutharsan, A., Gotsbacher, M., Brown, C., Ryan, R., Codd, R. (2022). Acetyl-CoA-Mediated Post-Biosynthetic Modification of Desferrioxamine B Generates N- and N-O-Acetylated Isomers Controlled by a pH Switch. ACS Chemical Biology, 17(2), 426-437. [More Information]
Gotsbacher, M., Codd, R. (2022). Adding a diazo-transfer reagent to culture to generate secondary metabolite probes for click chemistry. Methods in Enzymology, 665, 49-71. [More Information]
Brown, C., Codd, R. (2021). Directing macrocyclic architecture using iron(III)-, gallium(III)-, or zirconium(IV)-assisted ring closure of linear dimeric endo-hydroxamic acid ligands. Journal of Inorganic Biochemistry, 216, 111337. [More Information]
Gotsbacher, M., Codd, R. (2020). Azido-Desferrioxamine Siderophores as Functional Click-Chemistry Probes Generated in Culture upon Adding a Diazo-Transfer Reagent. ChemBioChem, 21(10), 1433-1445. [More Information]
Roth, L., Gotsbacher, M., Codd, R. (2020). Immobilized Metal Affinity Chromatography as a Drug Discovery Platform for Metalloenzyme Inhibitors. Journal of Medicinal Chemistry, 63(20), 12116-12127. [More Information]
Brown, C., Gotsbacher, M., Codd, R. (2020). Improved access to linear tetrameric hydroxamic acids with potential as radiochemical ligands for zirconium(IV)-89 PET imaging. Australian Journal of Chemistry, 73(10), 969-978. [More Information]
Telfer, T., Richardson-Sanchez, T., Gotsbacher, M., Nolan, K., Tieu, W., Codd, R. (2019). Analogues of desferrioxamine B (DFOB) with new properties and new functions generated using precursor-directed biosynthesis. Biometals, 32(3), 395-408. [More Information]
Brown, C., Gotsbacher, M., Holland, J., Codd, R. (2019). Endo-Hydroxamic Acid Monomers for the Assembly of a Suite of Non-native Dimeric Macrocyclic Siderophores Using Metal-Templated Synthesis. Inorganic Chemistry, 58(20), 13591-13603. [More Information]
Daniel, L., Gotsbacher, M., Richardson-Sanchez, T., Tieu, W., Codd, R. (2019). Exploring hydroxamic acid inhibitors of HDAC1 and HDAC2 using small molecule tools and molecular or homology modelling. Bioorganic & Medicinal Chemistry Letters, 29(18), 2581-2586. [More Information]
Ho Shon, I., Gotsbacher, M., Guille, J., Kumar, D., Codd, R., Hogg, P. (2019). Preparation of a Dithiol-Reactive Probe for PET Imaging of Cell Death. Methods in Molecular Biology, 1967, 295-304. [More Information]
Codd, R., Richardson-Sanchez, T., Telfer, T., Gotsbacher, M. (2018). Advances in the Chemical Biology of Desferrioxamine B. ACS Chemical Biology, 13(1), 11-25. [More Information]
Richardson-Sanchez, T., Codd, R. (2018). Engineering a cleavable disulfide bond into a natural product siderophore using precursor-directed biosynthesis. Chemical Communications, 54(70), 9813-9816. [More Information]
Telfer, T., Codd, R. (2018). Fluorinated Analogues of Desferrioxamine B from Precursor-Directed Biosynthesis Provide New Insight into the Capacity of DesBCD. ACS Chemical Biology, 13, 2456-2471. [More Information]
Richardson-Sanchez, T., Nolan, K., Codd, R. (2018). Rubik's Cube of Siderophore Assembly Established from Mixed-Substrate Precursor-Directed Biosynthesis. ACS Omega, 3(12), 18160-18169. [More Information]
Codd, R., Soe, C., Pakchung, A., Sresutharsan, A., Brown, C., Tieu, W. (2018). The chemical biology and coordination chemistry of putrebactin, avaroferrin, bisucaberin, and alcaligin. Journal of Biological Inorganic Chemistry, 23(7), 969-982. [More Information]
Telfer, T., Liddell, J., Duncan, C., White, A., Codd, R. (2017). Adamantyl- and other polycyclic cage-based conjugates of desferrioxamine B (DFOB) for treating iron-mediated toxicity in cell models of Parkinson's disease. Bioorganic and Medicinal Chemistry Letters, 27(8), 1698-1704. [More Information]
Gotsbacher, M., Telfer, T., Witting, P., Double, K., Finkelstein, D., Codd, R. (2017). Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease. Metallomics, 9(7), 852-864. [More Information]
Sresutharsan, A., Tieu, W., Richardson-Sanchez, T., Soe, C., Codd, R. (2017). Dimeric and trimeric homo- and heteroleptic hydroxamic acid macrocycles formed using mixed-ligand Fe(III)-based metal-templated synthesis. Journal of Inorganic Biochemistry, 177, 344-351. [More Information]
Richardson-Sanchez, T., Tieu, W., Gotsbacher, M., Telfer, T., Codd, R. (2017). Exploiting the biosynthetic machinery of Streptomyces pilosus to engineer a water-soluble zirconium(iv) chelator. Organic and Biomolecular Chemistry, 15(27), 5719-5730. [More Information]
Tieu, W., Lifa, T., Katsifis, A., Codd, R. (2017). Octadentate Zirconium(IV)-Loaded Macrocycles with Varied Stoichiometry Assembled From Hydroxamic Acid Monomers using Metal-Templated Synthesis. Inorganic Chemistry, 56(6), 3719-3728. [More Information]
Richardson-Sanchez, T., Tieu, W., Codd, R. (2017). Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads From Enzyme-Mediated Fragmentation of Natural Products. ChemBioChem, 18(4), 368-373. [More Information]
Telfer, T., Gotsbacher, M., Soe, C., Codd, R. (2016). Mixing Up the Pieces of the Desferrioxamine B Jigsaw Defines the Biosynthetic Sequence Catalyzed by DesD. ACS Chemical Biology, 11(5), 1452-1462. [More Information]
Soe, C., Telfer, T., Levina, A., Lay, P., Codd, R. (2016). Simultaneous biosynthesis of putrebactin, avaroferrin and bisucaberin by Shewanella putrefaciens and characterisation of complexes with iron(III), molybdenum(VI) or chromium(V). Journal of Inorganic Biochemistry, 162, 207-215. [More Information]
Liu, P., Sokolowski, N., Guo, S., Siddiqi, F., Atmadibrata, B., Telfer, T., Sun, Y., Zhang, L., Yu, D., McCarroll, J., Byrne, J., Codd, R., et al (2016). The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs. Oncotarget, 7(48), 79217-79232. [More Information]
Lifa, T., Tieu, W., Hocking, R., Codd, R. (2015). Forward and reverse (Retro) Iron(III) or gallium(III) desferrioxamine e and ring-expanded analogues prepared using metal-templated synthesis from endo -hydroxamic acid monomers. Inorganic Chemistry, 54(7), 3573-3583. [More Information]
Locock, K., Tran, H., Codd, R., Allan, R. (2015). Hands-On Approach to Structure Activity Relationships: The Synthesis, Testing, and Hansch Analysis of a Series of Acetylcholineesterase Inhibitors. Journal of Chemical Education, 92(10), 1745-1750. [More Information]
Nakano, I., Soe, C., Codd, R. (2015). Isolation of doxorubicin from a bacterial culture using immobilised metal ion affinity chromatography. RSC Advances, 5(58), 46437-46442. [More Information]
Gu, J., Codd, R. (2015). The resolution of two clinical agents, bleomycin and desferrioxamine B, from a Streptomyces verticillus fermentation mixture using multi-dimensional immobilised metal ion affinity chromatography. RSC Advances, 5(5), 3443-3453. [More Information]
Soe, C., Pakchung, A., Codd, R. (2014). Dinuclear [(VVO(putrebactin))2(m-OCH3)2] formed in solution as established from LC-MS measurements using 50V-enriched V2O5. Inorganic Chemistry, 53(11), 5852-5861. [More Information]
Soe, C., Codd, R. (2014). Unsaturated Macrocyclic Dihydroxamic Acid Siderophores Produced by Shewanella putrefaciens Using Precursor-Directed Biosynthesis. ACS Chemical Biology, 9(4), 945-956. [More Information]
Liddell, J., Obando, D., Liu, J., Ganio, G., Volitakis, I., San Mok, S., Crouch, P., White, A., Codd, R. (2013). Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease. Free Radical Biology and Medicine, 60, 147-156. [More Information]
Pakchung, A., Lifa, T., Codd, R. (2013). Solution species of Fe(III), Ga(III), In(III) or Ln(III) and suberodihydroxamic acid from electrospray ionization mass spectrometry. RSC Advances, 3(36), 16051-16059. [More Information]
Ejje, N., Soe, C., Gu, J., Codd, R. (2013). The variable hydroxamic acid siderophore metabolome of the marine actinomycete Salinispora tropica CNB-440. Metallomics, 5(11), 1519-1528. [More Information]
Liao, V., Liu, T., Codd, R. (2012). Amide-based derivatives of Î²-alanine hydroxamic acid as histone deacetylase inhibitors: Attenuation of potency through resonance effects. Bioorganic & Medicinal Chemistry Letters, 22(19), 6200-6204. [More Information]
Ejje, N., Lacey, E., Codd, R. (2012). Analytical-scale purification of trichostatin A from bacterial culture in a single step and with high selectivity using immobilised metal affinity chromatography. RSC Advances, 2(1), 333-337. [More Information]
Lifa, T., Ejje, N., Codd, R. (2012). Coordinate-bond-dependent solid-phase organic synthesis of biotinylated desferrioxamine B: a new route for metal-specific probes. Chemical Communications, 48(14), 2003-2005. [More Information]
Gu, J., Codd, R. (2012). Copper(II)-based metal affinity chromatography for the isolation of the anticancer agent bleomycin from Streptomyces verticillus culture. Journal of Inorganic Biochemistry, 115(198), 198-203. [More Information]
Soe, C., Pakchung, A., Codd, R. (2012). Directing the Biosynthesis of Putrebactin or Desferrioxamine B in Shewanella putrefaciens through the Upstream Inhibition of Ornithine Decarboxylase. Chemistry and Biodiversity, 9(9), 1880-1890. [More Information]
Hare, N., Soe, C., Rose, B., Harbour, C., Codd, R., Manos, J., Cordwell, S. (2012). Proteomics of Pseudomonas aeruginosa Australian Epidemic Strain 1 (AES-1) Cultured under Conditions Mimicking the Cystic Fibrosis Lung Reveals Increased Iron Acquisition via the Siderophore Pyochelin. Journal of Proteome Research, 11(2), 776-795. [More Information]
Simpson, P., Codd, R. (2011). Cold adaptation of the mononuclear molybdoenzyme periplasmic nitrate reductase from the Antarctic bacterium Shewanella gelidimarina. Biochemical and Biophysical Research Communications, 414(4), 783-788. [More Information]
Groebler, L., Liu, J., Shanu, A., Codd, R., Witting, P. (2011). Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl) carboxamide in a cell model of myoglobinuria. Biochemical Journal, 435(3), 669-677. [More Information]
Pakchung, A., Soe, C., Codd, R. (2011). Complexes Formed in Solution Between Vanadium (IV)/(V) and the Cyclic Dihydroxamic Acid Putrebactin or Linear Suberodihydroxamic Acid. Inorganic Chemistry, 50(13), 5978-5989. [More Information]
Liu, J., Obando Gutierrez, D., Liao, V., Lifa, T., Codd, R. (2011). The many faces of the adamantyl group in drug design. European Journal of Medicinal Chemistry, 46(6), 1949-1963. [More Information]
Wubben, J., Dogovski, C., Dobson, R., Codd, R., Gerrard, J., Parker, M., Perugini, M. (2010). Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66(pt 11), 1511-1516. [More Information]
Liu, J., Obando Gutierrez, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010). Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of Medicinal Chemistry, 53(3), 1370-1382. [More Information]
Simpson, P., McKinzie, A., Codd, R. (2010). Resolution of two native monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes. Biochemical and Biophysical Research Communications, 398(1), 13-18. [More Information]
Fainerman-Melnikova, M., Clegg, J., Pakchung, A., Jensen, P., Codd, R. (2010). Structural diversity of complexes between Cu(II) or Ni(II) and endocyclic oxygen- or nitrogen-containing ligands: Synthesis, X-ray structure determinations and circular dichroism spectra. CrystEngComm, 12(12), 4217-4225. [More Information]
Simpson, P., Richardson, D., Codd, R. (2010). The periplasmic nitrate reductase in Shewanella: The resolution, distribution and functional implications of two NAP isoforms, NapEDABC and NapDAGHB. Microbiology, 156(2), 302-312. [More Information]
Liu, J., Clegg, J., Codd, R. (2009). 2,5-Dioxopyrrolidin-1-yl adamantane-1-carboxylate. Acta Crystallographica. Section E: Structure Reports Online, E65, o1740-o1741. [More Information]
Liu, J., Clegg, J., Codd, R. (2009). Methyl 3-[(1adamantylcarbonyloxy)-aminocarbonyl] propanoate. Acta Crystallographica. Section E: Structure Reports Online, E65(0), o1752-o1743. [More Information]
Codd, R., Braich, N., Liu, J., Soe, C., Pakchung, A. (2009). Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A. International Journal of Biochemistry and Cell Biology, 41(4), 736-739. [More Information]
Braich, N., Codd, R. (2008). Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(III)-binding metabolites directly from bacterial culture supernatants. Analyst, 2008 (7), 877-880. [More Information]
Pakchung, A., Soe, C., Codd, R. (2008). Studies of iron-uptake mechanisms in two bacterial species of the Shewanella Genus adapted to middle-range (Shewanella putrefaciens) or Antarctic (Shewanella gelidimarina) temperatures. Chemistry and Biodiversity, 5(10), 2113-2123. [More Information]
Codd, R. (2008). Traversing the coordination chemistry and chemical biology of hydroxamic acids. Coordination Chemistry Reviews, 252, 1387-1408. [More Information]
Fainerman-Melnikova, M., Clegg, J., Codd, R. (2006). Aqua[bis(2-pyridylmethyl)amine][chelidonato(1.5-)]-copper(II) chelidonate(0.5â€“) monohydrate. Acta Crystallographica. Section E: Structure Reports Online, E62(12), m3582-m3584. [More Information]
Codd, R., Lay, P., Tsibakhashvili, N., Kalabegishvili, T., Murusidze, I., Holman, H. (2006). Chromium(V) complexes generated in Arthrobacter oxydans by simulation analysis of EPR spectra. Journal of Inorganic Biochemistry, 100(11), 1827-1833. [More Information]
Pakchung, A., Simpson, P., Codd, R. (2006). Life on earth. Extremophiles continue to move the goal posts. Environmental Chemistry, 3(2), 77-93. [More Information]
Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
Fainerman-Melnikova, M., Szabo-Planka, T., Rockenbauer, A., Codd, R. (2005). Coordination modes between copper(II) and N-acetylneuraminic (sialic) acid from a 2D-simulation analysis of EPR spectra. Implications for copper mediation of sialoglycoconjugate chemistry relevant to human biology. Inorganic Chemistry, 44(7), 2531-2543. [More Information]
Codd, R. (2004). Metalloglycomics: a new perspective upon competitive metal-carbohydrate binding using EPR spectroscopy. Chemical Communications, 2004 (23), 2653-2655. [More Information]
Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055. [More Information]
Codd, R., Lay, P. (2003). Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (Sialic) acids: an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI). Chemical Research in Toxicology, 16(7), 881-892.
Codd, R., Irwin, J., Lay, P. (2003). Sialoglycoprotein and carbohydrate complexes in chromium toxicity. Current Opinion In Chemical Biology, 7, 213-219. [More Information]
Raishbrook, S., Turner, P., Codd, R. (2002). A potential synthon for models of vanadium haloperoxidase: (3,5-dimethylpyrazole)-bis[2-hydroxy-2-methylbutanoato(1-)]-oxovanadium(IV). Acta Crystallographica. Section E: Structure Reports Online, E58(12), m737-m739.
Codd, R., Astashkin, A., Pacheco, A., Raitsimring, A., Enemark, J. (2002). Pulsed ELDOR spectroscopy of the Mo(V)/Fe(III) state of sulfite oxidase prepared by one-electron reduction with Ti(III) citrate. Journal of Biological Inorganic Chemistry, 7(3), 338-350. [More Information]
Codd, R., Lay, P. (2001). Chromium(V)-sialic (neuraminic) acid species are formed from mixtures of chromium(VI) and saliva. Journal of the American Chemical Society, 123, 11799-11800. [More Information]
Codd, R., Dillon, C., Levina, A., Lay, P. (2001). Studies on the genotoxicity of chromium: From the test tube to the cell. Coordination Chemistry Reviews, 216-217(3), 537-582. [More Information]
Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

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2024

Wood, J., Ghosh, S., Houston, Z., Fletcher, N., Humphries, J., Mardon, K., Akhter, D., Tieu, W., Ivashkevich, A., Wheatcroft, M., Codd, R., et al (2024). A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements. Chemical Science, 15(30), 11748-11760. [More Information]
Markham, T., Codd, R. (2024). A Mild and Modular Approach to the Total Synthesis of Desferrioxamine B. The Journal of Organic Chemistry, 89(7), 5118-5125. [More Information]
Nolan, K., Rosser, C., Wood, J., Font Sadurni, J., Sresutharsan, A., Wang, J., Markham, T., Ryan, R., Codd, R. (2024). An elastic siderophore synthetase and rubbery substrates assemble multimeric linear and macrocyclic hydroxamic acid metal chelators. Chemical Science. [More Information]
Richardson-Sanchez, T., Telfer, T., Soe, C., Nolan, K., Gotsbacher, M., Codd, R. (2024). The production of siderophore analogues using precursor-directed biosynthesis. Methods in Enzymology, 702, 121-145. [More Information]

show 1 more

2023

Ni, J., Wood, J., White, M., Lihi, N., Markham, T., Wang, J., Chivers, P., Codd, R. (2023). Reduction-cleavable desferrioxamine B pulldown system enriches Ni(ii)-superoxide dismutase from a Streptomyces proteome. RSC Chemical Biology, 4(12), 1064-1072. [More Information]
Codd, R. (2023). Siderophores and iron transport. In Jan Reedijk & Kenneth R. Poeppelmeier (Eds.), Comprehensive Inorganic Chemistry III, (pp. 3-29). Australia: Elsevier. [More Information]

2022

Ho Shon, I., Hennessy, T., Guille, J., Gotsbacher, M., Lay, A., McBride, B., Codd, R., Hogg, P. (2022). A first-in-human study of [68Ga]Ga-CDI: a positron emitting radiopharmaceutical for imaging tumour cell death. European Journal of Nuclear Medicine and Molecular Imaging, 49(12), 4037-4047. [More Information]
Nolan, K., Font Sadurni, J., Sresutharsan, A., Gotsbacher, M., Brown, C., Ryan, R., Codd, R. (2022). Acetyl-CoA-Mediated Post-Biosynthetic Modification of Desferrioxamine B Generates N- and N-O-Acetylated Isomers Controlled by a pH Switch. ACS Chemical Biology, 17(2), 426-437. [More Information]
Gotsbacher, M., Codd, R. (2022). Adding a diazo-transfer reagent to culture to generate secondary metabolite probes for click chemistry. Methods in Enzymology, 665, 49-71. [More Information]

2021

Brown, C., Codd, R. (2021). Directing macrocyclic architecture using iron(III)-, gallium(III)-, or zirconium(IV)-assisted ring closure of linear dimeric endo-hydroxamic acid ligands. Journal of Inorganic Biochemistry, 216, 111337. [More Information]

2020

Gotsbacher, M., Codd, R. (2020). Azido-Desferrioxamine Siderophores as Functional Click-Chemistry Probes Generated in Culture upon Adding a Diazo-Transfer Reagent. ChemBioChem, 21(10), 1433-1445. [More Information]
Roth, L., Gotsbacher, M., Codd, R. (2020). Immobilized Metal Affinity Chromatography as a Drug Discovery Platform for Metalloenzyme Inhibitors. Journal of Medicinal Chemistry, 63(20), 12116-12127. [More Information]
Brown, C., Gotsbacher, M., Codd, R. (2020). Improved access to linear tetrameric hydroxamic acids with potential as radiochemical ligands for zirconium(IV)-89 PET imaging. Australian Journal of Chemistry, 73(10), 969-978. [More Information]

2019

Telfer, T., Richardson-Sanchez, T., Gotsbacher, M., Nolan, K., Tieu, W., Codd, R. (2019). Analogues of desferrioxamine B (DFOB) with new properties and new functions generated using precursor-directed biosynthesis. Biometals, 32(3), 395-408. [More Information]
Brown, C., Gotsbacher, M., Holland, J., Codd, R. (2019). Endo-Hydroxamic Acid Monomers for the Assembly of a Suite of Non-native Dimeric Macrocyclic Siderophores Using Metal-Templated Synthesis. Inorganic Chemistry, 58(20), 13591-13603. [More Information]
Daniel, L., Gotsbacher, M., Richardson-Sanchez, T., Tieu, W., Codd, R. (2019). Exploring hydroxamic acid inhibitors of HDAC1 and HDAC2 using small molecule tools and molecular or homology modelling. Bioorganic & Medicinal Chemistry Letters, 29(18), 2581-2586. [More Information]
Ho Shon, I., Gotsbacher, M., Guille, J., Kumar, D., Codd, R., Hogg, P. (2019). Preparation of a Dithiol-Reactive Probe for PET Imaging of Cell Death. Methods in Molecular Biology, 1967, 295-304. [More Information]

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2018

Codd, R., Richardson-Sanchez, T., Telfer, T., Gotsbacher, M. (2018). Advances in the Chemical Biology of Desferrioxamine B. ACS Chemical Biology, 13(1), 11-25. [More Information]
Richardson-Sanchez, T., Codd, R. (2018). Engineering a cleavable disulfide bond into a natural product siderophore using precursor-directed biosynthesis. Chemical Communications, 54(70), 9813-9816. [More Information]
Telfer, T., Codd, R. (2018). Fluorinated Analogues of Desferrioxamine B from Precursor-Directed Biosynthesis Provide New Insight into the Capacity of DesBCD. ACS Chemical Biology, 13, 2456-2471. [More Information]
Richardson-Sanchez, T., Nolan, K., Codd, R. (2018). Rubik's Cube of Siderophore Assembly Established from Mixed-Substrate Precursor-Directed Biosynthesis. ACS Omega, 3(12), 18160-18169. [More Information]
Codd, R., Soe, C., Pakchung, A., Sresutharsan, A., Brown, C., Tieu, W. (2018). The chemical biology and coordination chemistry of putrebactin, avaroferrin, bisucaberin, and alcaligin. Journal of Biological Inorganic Chemistry, 23(7), 969-982. [More Information]

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2017

Telfer, T., Liddell, J., Duncan, C., White, A., Codd, R. (2017). Adamantyl- and other polycyclic cage-based conjugates of desferrioxamine B (DFOB) for treating iron-mediated toxicity in cell models of Parkinson's disease. Bioorganic and Medicinal Chemistry Letters, 27(8), 1698-1704. [More Information]
Gotsbacher, M., Telfer, T., Witting, P., Double, K., Finkelstein, D., Codd, R. (2017). Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease. Metallomics, 9(7), 852-864. [More Information]
Sresutharsan, A., Tieu, W., Richardson-Sanchez, T., Soe, C., Codd, R. (2017). Dimeric and trimeric homo- and heteroleptic hydroxamic acid macrocycles formed using mixed-ligand Fe(III)-based metal-templated synthesis. Journal of Inorganic Biochemistry, 177, 344-351. [More Information]
Richardson-Sanchez, T., Tieu, W., Gotsbacher, M., Telfer, T., Codd, R. (2017). Exploiting the biosynthetic machinery of Streptomyces pilosus to engineer a water-soluble zirconium(iv) chelator. Organic and Biomolecular Chemistry, 15(27), 5719-5730. [More Information]
Tieu, W., Lifa, T., Katsifis, A., Codd, R. (2017). Octadentate Zirconium(IV)-Loaded Macrocycles with Varied Stoichiometry Assembled From Hydroxamic Acid Monomers using Metal-Templated Synthesis. Inorganic Chemistry, 56(6), 3719-3728. [More Information]
Richardson-Sanchez, T., Tieu, W., Codd, R. (2017). Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads From Enzyme-Mediated Fragmentation of Natural Products. ChemBioChem, 18(4), 368-373. [More Information]

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2016

Telfer, T., Gotsbacher, M., Soe, C., Codd, R. (2016). Mixing Up the Pieces of the Desferrioxamine B Jigsaw Defines the Biosynthetic Sequence Catalyzed by DesD. ACS Chemical Biology, 11(5), 1452-1462. [More Information]
Soe, C., Telfer, T., Levina, A., Lay, P., Codd, R. (2016). Simultaneous biosynthesis of putrebactin, avaroferrin and bisucaberin by Shewanella putrefaciens and characterisation of complexes with iron(III), molybdenum(VI) or chromium(V). Journal of Inorganic Biochemistry, 162, 207-215. [More Information]
Liu, P., Sokolowski, N., Guo, S., Siddiqi, F., Atmadibrata, B., Telfer, T., Sun, Y., Zhang, L., Yu, D., McCarroll, J., Byrne, J., Codd, R., et al (2016). The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs. Oncotarget, 7(48), 79217-79232. [More Information]

2015

Lifa, T., Tieu, W., Hocking, R., Codd, R. (2015). Forward and reverse (Retro) Iron(III) or gallium(III) desferrioxamine e and ring-expanded analogues prepared using metal-templated synthesis from endo -hydroxamic acid monomers. Inorganic Chemistry, 54(7), 3573-3583. [More Information]
Locock, K., Tran, H., Codd, R., Allan, R. (2015). Hands-On Approach to Structure Activity Relationships: The Synthesis, Testing, and Hansch Analysis of a Series of Acetylcholineesterase Inhibitors. Journal of Chemical Education, 92(10), 1745-1750. [More Information]
Nakano, I., Soe, C., Codd, R. (2015). Isolation of doxorubicin from a bacterial culture using immobilised metal ion affinity chromatography. RSC Advances, 5(58), 46437-46442. [More Information]
Gu, J., Codd, R. (2015). The resolution of two clinical agents, bleomycin and desferrioxamine B, from a Streptomyces verticillus fermentation mixture using multi-dimensional immobilised metal ion affinity chromatography. RSC Advances, 5(5), 3443-3453. [More Information]

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2014

Soe, C., Pakchung, A., Codd, R. (2014). Dinuclear [(VVO(putrebactin))2(m-OCH3)2] formed in solution as established from LC-MS measurements using 50V-enriched V2O5. Inorganic Chemistry, 53(11), 5852-5861. [More Information]
Codd, R., Gu, J., Ejje, N., Lifa, T. (2014). New Applications of Immobilized Metal Ion Affinity Chromatography in Chemical Biology. In Gilles Gasser (Eds.), Inorganic Chemical Biology: Principles, Techniques and Applications, (pp. 1-35). Chichester: John Wiley & Sons. [More Information]
Soe, C., Codd, R. (2014). Unsaturated Macrocyclic Dihydroxamic Acid Siderophores Produced by Shewanella putrefaciens Using Precursor-Directed Biosynthesis. ACS Chemical Biology, 9(4), 945-956. [More Information]

2013

Liddell, J., Obando, D., Liu, J., Ganio, G., Volitakis, I., San Mok, S., Crouch, P., White, A., Codd, R. (2013). Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease. Free Radical Biology and Medicine, 60, 147-156. [More Information]
Pakchung, A., Lifa, T., Codd, R. (2013). Solution species of Fe(III), Ga(III), In(III) or Ln(III) and suberodihydroxamic acid from electrospray ionization mass spectrometry. RSC Advances, 3(36), 16051-16059. [More Information]
Ejje, N., Soe, C., Gu, J., Codd, R. (2013). The variable hydroxamic acid siderophore metabolome of the marine actinomycete Salinispora tropica CNB-440. Metallomics, 5(11), 1519-1528. [More Information]

2012

Liao, V., Liu, T., Codd, R. (2012). Amide-based derivatives of Î²-alanine hydroxamic acid as histone deacetylase inhibitors: Attenuation of potency through resonance effects. Bioorganic & Medicinal Chemistry Letters, 22(19), 6200-6204. [More Information]
Ejje, N., Lacey, E., Codd, R. (2012). Analytical-scale purification of trichostatin A from bacterial culture in a single step and with high selectivity using immobilised metal affinity chromatography. RSC Advances, 2(1), 333-337. [More Information]
Lifa, T., Ejje, N., Codd, R. (2012). Coordinate-bond-dependent solid-phase organic synthesis of biotinylated desferrioxamine B: a new route for metal-specific probes. Chemical Communications, 48(14), 2003-2005. [More Information]
Gu, J., Codd, R. (2012). Copper(II)-based metal affinity chromatography for the isolation of the anticancer agent bleomycin from Streptomyces verticillus culture. Journal of Inorganic Biochemistry, 115(198), 198-203. [More Information]
Soe, C., Pakchung, A., Codd, R. (2012). Directing the Biosynthesis of Putrebactin or Desferrioxamine B in Shewanella putrefaciens through the Upstream Inhibition of Ornithine Decarboxylase. Chemistry and Biodiversity, 9(9), 1880-1890. [More Information]
Hare, N., Soe, C., Rose, B., Harbour, C., Codd, R., Manos, J., Cordwell, S. (2012). Proteomics of Pseudomonas aeruginosa Australian Epidemic Strain 1 (AES-1) Cultured under Conditions Mimicking the Cystic Fibrosis Lung Reveals Increased Iron Acquisition via the Siderophore Pyochelin. Journal of Proteome Research, 11(2), 776-795. [More Information]

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2011

Simpson, P., Codd, R. (2011). Cold adaptation of the mononuclear molybdoenzyme periplasmic nitrate reductase from the Antarctic bacterium Shewanella gelidimarina. Biochemical and Biophysical Research Communications, 414(4), 783-788. [More Information]
Groebler, L., Liu, J., Shanu, A., Codd, R., Witting, P. (2011). Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl) carboxamide in a cell model of myoglobinuria. Biochemical Journal, 435(3), 669-677. [More Information]
Pakchung, A., Soe, C., Codd, R. (2011). Complexes Formed in Solution Between Vanadium (IV)/(V) and the Cyclic Dihydroxamic Acid Putrebactin or Linear Suberodihydroxamic Acid. Inorganic Chemistry, 50(13), 5978-5989. [More Information]
Liu, J., Obando Gutierrez, D., Liao, V., Lifa, T., Codd, R. (2011). The many faces of the adamantyl group in drug design. European Journal of Medicinal Chemistry, 46(6), 1949-1963. [More Information]

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2010

Wubben, J., Dogovski, C., Dobson, R., Codd, R., Gerrard, J., Parker, M., Perugini, M. (2010). Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66(pt 11), 1511-1516. [More Information]
Liu, J., Obando Gutierrez, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010). Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of Medicinal Chemistry, 53(3), 1370-1382. [More Information]
Simpson, P., McKinzie, A., Codd, R. (2010). Resolution of two native monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes. Biochemical and Biophysical Research Communications, 398(1), 13-18. [More Information]
Fainerman-Melnikova, M., Clegg, J., Pakchung, A., Jensen, P., Codd, R. (2010). Structural diversity of complexes between Cu(II) or Ni(II) and endocyclic oxygen- or nitrogen-containing ligands: Synthesis, X-ray structure determinations and circular dichroism spectra. CrystEngComm, 12(12), 4217-4225. [More Information]
Simpson, P., Richardson, D., Codd, R. (2010). The periplasmic nitrate reductase in Shewanella: The resolution, distribution and functional implications of two NAP isoforms, NapEDABC and NapDAGHB. Microbiology, 156(2), 302-312. [More Information]

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2009

Liu, J., Clegg, J., Codd, R. (2009). 2,5-Dioxopyrrolidin-1-yl adamantane-1-carboxylate. Acta Crystallographica. Section E: Structure Reports Online, E65, o1740-o1741. [More Information]
Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer. [More Information]
Liu, J., Clegg, J., Codd, R. (2009). Methyl 3-[(1adamantylcarbonyloxy)-aminocarbonyl] propanoate. Acta Crystallographica. Section E: Structure Reports Online, E65(0), o1752-o1743. [More Information]
Codd, R., Braich, N., Liu, J., Soe, C., Pakchung, A. (2009). Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A. International Journal of Biochemistry and Cell Biology, 41(4), 736-739. [More Information]

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2008

Braich, N., Codd, R. (2008). Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(III)-binding metabolites directly from bacterial culture supernatants. Analyst, 2008 (7), 877-880. [More Information]
Pakchung, A., Soe, C., Codd, R. (2008). Studies of iron-uptake mechanisms in two bacterial species of the Shewanella Genus adapted to middle-range (Shewanella putrefaciens) or Antarctic (Shewanella gelidimarina) temperatures. Chemistry and Biodiversity, 5(10), 2113-2123. [More Information]
Codd, R. (2008). Traversing the coordination chemistry and chemical biology of hydroxamic acids. Coordination Chemistry Reviews, 252, 1387-1408. [More Information]

2006

Fainerman-Melnikova, M., Clegg, J., Codd, R. (2006). Aqua[bis(2-pyridylmethyl)amine][chelidonato(1.5-)]-copper(II) chelidonate(0.5â€“) monohydrate. Acta Crystallographica. Section E: Structure Reports Online, E62(12), m3582-m3584. [More Information]
Codd, R., Lay, P., Tsibakhashvili, N., Kalabegishvili, T., Murusidze, I., Holman, H. (2006). Chromium(V) complexes generated in Arthrobacter oxydans by simulation analysis of EPR spectra. Journal of Inorganic Biochemistry, 100(11), 1827-1833. [More Information]
Pakchung, A., Simpson, P., Codd, R. (2006). Life on earth. Extremophiles continue to move the goal posts. Environmental Chemistry, 3(2), 77-93. [More Information]

2005

Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
Fainerman-Melnikova, M., Szabo-Planka, T., Rockenbauer, A., Codd, R. (2005). Coordination modes between copper(II) and N-acetylneuraminic (sialic) acid from a 2D-simulation analysis of EPR spectra. Implications for copper mediation of sialoglycoconjugate chemistry relevant to human biology. Inorganic Chemistry, 44(7), 2531-2543. [More Information]

2004

Codd, R. (2004). Metalloglycomics: a new perspective upon competitive metal-carbohydrate binding using EPR spectroscopy. Chemical Communications, 2004 (23), 2653-2655. [More Information]
Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055. [More Information]

2003

Codd, R. (2003). Biomolecules from extremophilic life. In Nicholls, Pailthorpe (Eds.), From Zero to Infinity, (pp. 37-48). Sydney: Science Foundation for Physics.
Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.
Codd, R., Lay, P. (2003). Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (Sialic) acids: an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI). Chemical Research in Toxicology, 16(7), 881-892.
Codd, R., Irwin, J., Lay, P. (2003). Sialoglycoprotein and carbohydrate complexes in chromium toxicity. Current Opinion In Chemical Biology, 7, 213-219. [More Information]

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2002

Raishbrook, S., Turner, P., Codd, R. (2002). A potential synthon for models of vanadium haloperoxidase: (3,5-dimethylpyrazole)-bis[2-hydroxy-2-methylbutanoato(1-)]-oxovanadium(IV). Acta Crystallographica. Section E: Structure Reports Online, E58(12), m737-m739.
Codd, R., Astashkin, A., Pacheco, A., Raitsimring, A., Enemark, J. (2002). Pulsed ELDOR spectroscopy of the Mo(V)/Fe(III) state of sulfite oxidase prepared by one-electron reduction with Ti(III) citrate. Journal of Biological Inorganic Chemistry, 7(3), 338-350. [More Information]

2001

Codd, R., Lay, P. (2001). Chromium(V)-sialic (neuraminic) acid species are formed from mixtures of chromium(VI) and saliva. Journal of the American Chemical Society, 123, 11799-11800. [More Information]
Codd, R., Dillon, C., Levina, A., Lay, P. (2001). Studies on the genotoxicity of chromium: From the test tube to the cell. Coordination Chemistry Reviews, 216-217(3), 537-582. [More Information]

2000

Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

Selected Grants

2024

Generation of D2 Derivatives for AMTAR project 3, Codd R, Telix Pharmaceuticals (Innovations) Pty Ltd/Pre-Clinical Research Services Agreement
Developing a targeted radiopharmaceutical theranostic for soft tissue sarcoma, Codd R, Tour de Cure Ltd/Pioneering Research Grant

2023

Rewarding Research 2024, Codd R, Faculty of Medicine and Health/FMH Rewarding Research Success
Efficacy and toxicity measures of a new class of iron chelator, Codd R, Centre for Drug Discovery Innovation/Capability Access
PROJECT 11 - ARC Industrial Transformation Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals, Codd R, University of Queensland/ARC Linkage Collaborating Organisation
ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals (AMTAR), Codd R, Kuncic Z, Hogg P,
Radiochemistry Facility for Biomolecule Characterisation in Living Systems, Kassiou M, New E, Codd R, Meikle S, Calamante F, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)

2022

Repurposing anticancer agents as antibiotics with new mechanisms of action, Codd R, Centre for Drug Discovery Innovation/Sydney ID Seed Funding
Clinical development of a self-amplifying pan-tumour theranostic, Hogg P, Simes R, Codd R, Scott A, Barrington S, Stockler M, Ho Shon I, Gebski V, Goldstein D, Thompson S, Cancer Institute NSW/Translational Program Grant
Enzyme-Mediated Machining of Chelators to Bind and Recover Valuable Metals, Codd R, Ryan R, Australian Research Council (ARC)/Discovery Projects (DP)

2021

Automated Compound Purification Platform to accelerate Nanosensing and Drug Discovery, King M, Codd R, Sunde M, Kaur A, DVC Research/Equipment Grant

2020

The active and selective import of anticancer agents as a potential antibacterial mechanism, Codd R, Hogg P, Gotsbacher M, University of Sydney/Seed Funding Grant

2019

High Resolution PET-CT for Small Animal Molecular and Anatomical Imaging, Meikle S, Calamante F, Balleine B, Kassiou M, Ittner L, Vittorio O, Gregoire M, Goldys E, Kuncic Z, Codd R, Rozenfeld A, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
Superoxide dismutase one dysfunction: a novel pathogenic mechanism in Parkinson disease, Double K, Hare D, Codd R, National Health and Medical Research Council (NHMRC)/Ideas Grant
Does dopamine cell death result from a novel proteinopathy in Parkinsons Disease brain, Double K, Cordwell S, Codd R, Trist B, Michael J Fox Foundation for Parkinsons Research/Research Support

2018

Resin for enriching phosphoproteome, Codd R, Faculty of Medicine and Health/IP Grants & SPARK Program
A dual-purpose ligand for immunological radiochemistry applications (200930, 2019-063), Codd R, Sydney Medical School/Industry Engagement Seed Fund
Engineered Virulence Factors with Potential Applications in AMR and Biosurveillance, Codd R, Neto C, Sintchenko V, Manos J, Marie Bashir Institute for Infectious Diseases and Biosecurity/Seed Funding Grants

2017

An Interdisciplinary Project in Drug Discovery, Todd M, Codd R, Randal N, DVC Education/Large Educational Innovation Grant
EasyMax 402 Advanced Synthesis Workstation, Kassiou M, Codd R, Collins M, University of Sydney/Equipment Grant
NSW Molecular analysis Platform: FTICR Mass Spectrometry and CHN&S analyser, Groundwater P, Payne R, Gale P, Karuso P, Kumar N, McCluskey A, Mitchell T, Doble P, Richardson D, Codd R, Rodger A, Venkatesan K, Raftery M, Donald W, Williams D, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
Mixing the Jigsaw Pieces of Natural Products: New Molecules-New Properties, Codd R, Hunter L, Darwish T, Anderson G, Australian Research Council (ARC)/Discovery Projects (DP)
SMS MCR Accelerator Grant 2017, Codd R, Sydney Medical School/Mid Career Researcher Scheme (MCRS)

2016

SMS MCR Accelerator Grant 2016 - Codd, Codd R, Sydney Medical School/Mid Career Researcher Scheme (MCRS)

2015

Using nanotechnology to improve the therapeutic efficiency of iron chelators, Anderson G, Nie G, Codd R, Pasricha S, National Health and Medical Research Council (NHMRC)/Project Grants

2014

UPLC-MS for rapid analysis and detection of bioactive molecules, Payne R, Cordwell S, Jolliffe K, Belov K, Codd R, National Health and Medical Research Council (NHMRC)/Equipment Grant
Preparative High-Performance Liquid Chromatograph (Preparative-HPLC) for Expediting Drug Translation , Codd R, Payne R, Kassiou M, Groundwater P, Munoz L, DVC Research/Equipment Grant
Engineered Hydroxamic Acids for Zirconium-89 Positron Emission Tomography (PET) Imaging of Prostate Cancer, Codd R, Katsifis A, Australian Research Council (ARC)/Discovery Projects (DP)

2013

CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility, Allbutt H, Ammit A, Assinder S, Bao B, Barrs V, Black J, Brennan-Speranza T, Buckland M, Burgess J, Byrne M, Camp A, Christopherson R, Codd R, Day M, de Graaf S, Dixon K, Dong Q, Dos Remedios C, Fraser S, Fu D, Goldsbury C, Groundwater P, Halliday G, Hambly B, Hardikar A, Hibbs D, Ho P, Hong A, Huang M, Huq F, Jansson P, Johnstone D, Joshua D, Ju Y, Kalinowski D, King N, Kovacevic Z, Kril J, Lai D, Lane D, Lay P, Lee C, Lok H, Lovicu F, Lu Z, Lyons J, Mason R, McLennan S, Morris B, Murphy C, Murray M, Naylor M, Oliver B, Owens T, Poronnik P, Rendina L, Richardson D, Ryan R, Sahni S, Scolyer R, Shafie N, Sharland A, Slobedman B, Sunde M, Sutherland G, Triccas J, Williamson P, Zhu L, Zreiqat H, National Health and Medical Research Council (NHMRC)/Equipment Grant
Agents targeting iron in the brain in Parkinsons disease, Codd R, Double K, Liddell J, Witting P, National Health and Medical Research Council (NHMRC)/Project Grants

2012

QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility, Ammit A, Bagley E, Bao B, Boyer M, Byrne M, Camp A, Day M, Dong Q, Dos Remedios C, Fraser S, Fu D, Hanrahan J, Hibbs D, Huang M, Jansson P, Ju Y, Kovacevic Z, Kril J, Lai D, Lane D, Lay P, Lyons J, Morris B, Murphy C, Rendina L, Richardson D, Sutherland G, Vandenberg R, Whittington R, Zhang D, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B, National Health and Medical Research Council (NHMRC)/Equipment Grant
Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility, Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons J, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho P, Williamson P, Murphy C, DVC Research/Equipment Grant
New agents with potential for mobilising iron in the brain, Codd R, White A, Parkinsons New South Wales Incorporated/Research Support

2011

A flexible high throughput analytical system for psychopharmacology and drug discovery, McGregor I, Simpson S, Weickert C, Kassiou M, Copeland J, Solowij N, Codd R, Arnold J, Karl T, Long L, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
GeneAtlas Personal Microarray System, Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C, National Health and Medical Research Council (NHMRC)/Equipment Grant
Iron overload compounds, Codd R, Australian Red Cross Blood Service/Research Support

2008

A Trilateral Approach in Chemical Biology to Isolate Siderophores with Potential Antitumour Properties, Codd R, DVC Research/Bridging Support Grant
Affinity-based profiling of bacterial Fe(III)-siderophore receptors: design strategies for antibiotics and iron overload, Codd R, National Health and Medical Research Council (NHMRC)/Project Grants
Biocombinatorial Synthesis of Histone Deacetylase Inhibitors as Chemotherapeutic Agents for Leukaemia and Lymphoma, Codd R, Cancer Institute NSW/Research Innovation Grants

2006

Molecular Engineering of Industrial Biocatalysts that Function in the Cold: Redox-Active Metalloproteins from Antarctic Bacteria, Codd R, University of Sydney/Bridging Support

2005

Adaptations to the nitrate reductase from the deep-sea dwelling bacterium, Shewanella benthica, Codd R, The Hermon Slade Foundation/HSF Research Grants
University of Sydney - Bridging Support Grant, Codd R, University of Sydney/Bridging Support

2004

Cold-Adapted Siderophores From Antarctic Bacteria, Codd R, Richardson D, University of Sydney/Research & Development

2003

Molecular characterisation of cold-adapted metalloxotransferases from the dimethylsulfoxide reductase family expressed by antarctic bacteria, Codd R, Australian Antarctic Division/Research Grant

2001

Metallated Proteins Expressed by Psychrophilic Bacteria, Codd R, Australian Antarctic Division/Australian Antarctic Science Program (formerly Australian Antarctic Science Grants)
In Vitro Speciation Studies between Sialic Acid and Serum Transition Metals, Codd R, DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS)

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Professor Rachel Codd

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