Associate Professor Rachel Codd

Associate Professor
Pharmacology, School of Medical Sciences
Bosch Institute

Cancer research network

Telephone +61 2 9351 6738
Fax +61 2 9351 3868

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Biographical details

  • BSc (Hons), School of Chemistry, University of Sydney, 1992
  • PhD, School of Chemistry, University of Sydney, 1998
  • Postdoctoral Research Associate, School of Biochemistry and Molecular Genetics, University of New South Wales, 1997-1999
  • Postdoctoral Research Associate, Department of Chemistry, University of Arizona, USA, 1999-2000
  • Gritton Research Fellow, School of Chemistry, University of Sydney, 2000
  • Lecturer, School of Chemistry, University of Sydney, 2001
  • Lecturer, School of Medical Sciences, University of Sydney, 2007
  • Senior Lecturer, School of Medical Sciences, University of Sydney, 2010
  • Associate Professor, School of Medical Sciences, University of Sydney, 2013

Research interests

My broad research expertise is in inorganic chemical biology and medicinal chemistry. I study the inorganic chemical biology of a class of bacterial metabolites known as siderophores that have a high affinity towards iron(III) and other metal ions of relevance to biomedicine and biomedical imaging. My cross-discipline research traverses chemistry (inorganic, organic, and medicinal), biochemistry, microbiology and biotechnology. My group has developed a water-compatible method in affinity chromatography to select for clinical bacterial metabolites from complex fermentation mixtures. This method is particularly successful for the streamlined isolation of bacterial siderophores and for the anticancer agent doxorubicin, and could have potential for green chemistry processing of pharmaceutics. This analytical method has allowed us to map low-abundant siderophore metabolomes in marine and terrestrial bacteria.

 

My group has recently shed new light on the biosynthesis of the siderophore desferrioxamine B (DFOB), which is a clinical agent used to treat secondary iron overload, which occurs in people with inherited transfusion-dependent blood disorders. We mapped using LC-MS/MS the distribution of the pieces of the DFOB jigsaw during its biosynthesis in situ, which allowed us to determine the sequence of events of its assembly in the final stages. This knowledge has underpinned our pioneering methods that use the bacterial biosynthetic machinery to furnish new siderophores as drug candidates with potential for treating secondary iron overload disease, and as ligands with potential for metallo-radionuclide imaging of cancer.

 

We have also developed methods in metal-templated synthesis to deliver known and new macrocyclic siderophores. My group has used semi-synthetic chemistry to produce new DFOB analogues that have shown promise as iron(III) binding molecules in in vitro and in vivo (MPTP-mouse) models of Parkinson's disease. A number of the biological studies are conducted with collaborating researchers at the QIMR Berghofer Medical Research Institute, The Department of PET and Nuclear Medicine (RPAH), The University of Melbourne, the Florey Institute of Neuroscience and Mental Health, and the Children's Cancer Institute. In other projects, my group has discovered a highly innovative method to discover drugs from natural products. We also conduct more traditional drug design projects - with a twist - aimed to discover new inhibitors against histone deacetylases, which is a verified cancer target. My research innovations have resulted in one PCT (granted in 2012/2013 the US, AU, EU) and three provisional patents (2015, 2016 (2)).

Teaching and supervision

I have a major teaching presence into PCOL3012/3912 Drug Design & Development and frequently act as the UoS Coordinator (2010-2012, 2015). I also teach into PCOL2011 Pharmacology Fundamentals. I am the UoS Coordinator for PCOL4011 Honours in Pharmacology (2010-2012, 2014-current).

Current research students

Project title Research student
Re-engineering hydroxamic acids in therapeutics and diagnostics Tomas RICHARDSON-SANCHEZ
Modulating the Pharmacokinetics of Desferrioxamine B using Semi-Synthetic Chemistry and Precursor-Directed Biosynthesis Thomas TELFER

Current projects

  • Metal-Templated Synthesis of Hydroxamic Acid Macrocycles
  • Semi-Synthetic Analogues of Desferrixoamine B as Agents with Potential for Parkinson's Disease
  • Design and Synthesis of Isoform-Selective Inhibitors of Histone Deacetylases
  • Using Bacteria as Biosynthetic Machines to Generate New Siderophores
  • Immobilised Metal Ion Affinity Chromatography to Isolate Clinical Bacterial Metabolites
  • A New Perspective on Natural Products as a Resource for Drug Discovery

Awards and honours

  • Selby Research Award, 2003
  • Cancer Institute NSW Innovation Award, 2009
  • Sir Zelman Cowen Universities Fund Prize for Medical Research, 2010
  • Biota Medal for Medicinal Chemistry, 2010
  • Semi-Finalist: Elsevier Green and Sustainable Chemistry Challenge, 2015
  • Sydney Medical School Award for Excellence in Research Supervision, 2015
  • Elected a Fellow of the Royal Australian Chemical Institute (FRACI), 2016

PhD and master's project opportunities

Selected grants

2016

  • Using nanotechnology to improve the therapeutic efficiency of iron chelators; Anderson G, Nie G, Codd R, Pasricha S; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • UPLC-MS for rapid analysis and detection of bioactive molecules; Payne R, Cordwell S, Jolliffe K, Belov K, Codd R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Preparative High-Performance Liquid Chromatograph (Preparative-HPLC) for Expediting Drug Translation; Codd R, Payne R, Kassiou M, Groundwater P, Munoz L; DVC Research/Equipment Grant.

2014

  • Engineered Hydroxamic Acids for Zirconium-89 Positron Emission Tomography (PET) Imaging of Prostate Cancer; Codd R, Katsifis A; Australian Research Council (ARC)/Discovery Projects (DP).
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Agents targeting iron in the brain in Parkinsons disease; Codd R, Double K, Liddell J, Witting P; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • New agents with potential for mobilising iron in the brain; Codd R, White A; Parkinsons New South Wales Incorporated/Research Support.
  • Iron overload compounds; Codd R; Australian Red Cross Blood Service/Research Support.
  • A flexible high throughput analytical system for psychopharmacology and drug discovery; McGregor I, Simpson S, Shannon Weickert C, Kassiou M, Copeland J, Solowij N, Codd R, Arnold J, Karl T, Long L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • A Trilateral Approach in Chemical Biology to Isolate Siderophores with Potential Antitumour Properties; Codd R; DVC Research/Bridging Support Grant.
  • Biocombinatorial Synthesis of Histone Deacetylase Inhibitors as Chemotherapeutic Agents for Leukaemia and Lymphoma; Codd R; Cancer Institute New South Wales/Research Innovation Grants.
  • Affinity-based profiling of bacterial Fe(III)-siderophore receptors: design strategies for antibiotics and iron overload; Codd R; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Molecular Engineering of Industrial Biocatalysts that Function in the Cold: Redox-Active Metalloproteins from Antarctic Bacteria; Codd R; University of Sydney/Bridging Support.

2006

  • Adaptations to the nitrate reductase from the deep-sea dwelling bacterium, Shewanella benthica; Codd R; The Hermon Slade Foundation/HSF Research Grants.
  • University of Sydney - Bridging Support Grant; Codd R; University of Sydney/Bridging Support.

2005

  • Cold-Adapted Siderophores From Antarctic Bacteria; Codd R, Richardson D; University of Sydney/Research & Development.

2004

  • Molecular characterisation of cold-adapted metalloxotransferases from the dimethylsulfoxide reductase family expressed by antarctic bacteria; Codd R; Australian Antarctic Division/Research Grant.

2002

  • In Vitro Speciation Studies between Sialic Acid and Serum Transition Metals; Codd R; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).
  • Metallated Proteins Expressed by Psychrophilic Bacteria; Codd R; Australian Antarctic Division/Australian Antarctic Science Program (formerly Australian Antarctic Science Grants).

Selected publications

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Book Chapters

  • Codd, R., Gu, J., Ejje, N., Lifa, T. (2014). New Applications of Immobilized Metal Ion Affinity Chromatography in Chemical Biology. In Gilles Gasser (Eds.), Inorganic Chemical Biology: Principles, Techniques and Applications, (pp. 1-35). Chichester: John Wiley & Sons.
  • Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer.
  • Codd, R. (2003). Biomolecules from extremophilic life. In Nicholls, Pailthorpe (Eds.), From Zero to Infinity, (pp. 37-48). Sydney: Science Foundation for Physics.
  • Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.

Journals

  • Telfer, T., Gotsbacher, M., Soe, C., Codd, R. (2016). Mixing Up the Pieces of the Desferrioxamine B Jigsaw Defines the Biosynthetic Sequence Catalyzed by DesD. ACS Chemical Biology, 11(5), 1452-1462. [More Information]
  • Lifa, T., Tieu, W., Hocking, R., Codd, R. (2015). Forward and reverse (Retro) Iron(III) or gallium(III) desferrioxamine e and ring-expanded analogues prepared using metal-templated synthesis from endo -hydroxamic acid monomers. Inorganic Chemistry, 54(7), 3573-3583. [More Information]
  • Locock, K., Tran, H., Codd, R., Allan, R. (2015). Hands-On Approach to Structure Activity Relationships: The Synthesis, Testing, and Hansch Analysis of a Series of Acetylcholineesterase Inhibitors. Journal of Chemical Education, 92(10), 1745-1750. [More Information]
  • Nakano, I., Soe, C., Codd, R. (2015). Isolation of doxorubicin from a bacterial culture using immobilised metal ion affinity chromatography. RSC Advances, 5(58), 46437-46442. [More Information]
  • Gu, J., Codd, R. (2015). The resolution of two clinical agents, bleomycin and desferrioxamine B, from a Streptomyces verticillus fermentation mixture using multi-dimensional immobilised metal ion affinity chromatography. RSC Advances, 5(5), 3443-3453. [More Information]
  • Soe, C., Pakchung, A., Codd, R. (2014). Dinuclear [(VVO(putrebactin))2(m-OCH3)2] formed in solution as established from LC-MS measurements using 50V-enriched V2O5. Inorganic Chemistry, 53(11), 5852-5861. [More Information]
  • Soe, C., Codd, R. (2014). Unsaturated Macrocyclic Dihydroxamic Acid Siderophores Produced by Shewanella putrefaciens Using Precursor-Directed Biosynthesis. ACS Chemical Biology, 9(4), 945-956. [More Information]
  • Liddell, J., Obando, D., Liu, J., Ganio, G., Volitakis, I., San Mok, S., Crouch, P., White, A., Codd, R. (2013). Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease. Free Radical Biology and Medicine, 60, 147-156. [More Information]
  • Pakchung, A., Lifa, T., Codd, R. (2013). Solution species of Fe(III), Ga(III), In(III) or Ln(III) and suberodihydroxamic acid from electrospray ionization mass spectrometry. RSC Advances, 3(36), 16051-16059. [More Information]
  • Ejje, N., Soe, C., Gu, J., Codd, R. (2013). The variable hydroxamic acid siderophore metabolome of the marine actinomycete Salinispora tropica CNB-440. Metallomics, 5(11), 1519-1528. [More Information]
  • Liao, V., Liu, T., Codd, R. (2012). Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: Attenuation of potency through resonance effects. Bioorganic & Medicinal Chemistry Letters, 22(19), 6200-6204. [More Information]
  • Ejje, N., Lacey, E., Codd, R. (2012). Analytical-scale purification of trichostatin A from bacterial culture in a single step and with high selectivity using immobilised metal affinity chromatography. RSC Advances, 2(1), 333-337. [More Information]
  • Lifa, T., Ejje, N., Codd, R. (2012). Coordinate-bond-dependent solid-phase organic synthesis of biotinylated desferrioxamine B: a new route for metal-specific probes. Chemical Communications, 48(14), 2003-2005. [More Information]
  • Gu, J., Codd, R. (2012). Copper(II)-based metal affinity chromatography for the isolation of the anticancer agent bleomycin from Streptomyces verticillus culture. Journal of Inorganic Biochemistry, 115(198), 198-203. [More Information]
  • Soe, C., Pakchung, A., Codd, R. (2012). Directing the Biosynthesis of Putrebactin or Desferrioxamine B in Shewanella putrefaciens through the Upstream Inhibition of Ornithine Decarboxylase. Chemistry and Biodiversity, 9(9), 1880-1890. [More Information]
  • Hare, N., Soe, C., Rose, B., Harbour, C., Codd, R., Manos, J., Cordwell, S. (2012). Proteomics of Pseudomonas aeruginosa Australian Epidemic Strain 1 (AES-1) Cultured under Conditions Mimicking the Cystic Fibrosis Lung Reveals Increased Iron Acquisition via the Siderophore Pyochelin. Journal of Proteome Research, 11(2), 776-795. [More Information]
  • Simpson, P., Codd, R. (2011). Cold adaptation of the mononuclear molybdoenzyme periplasmic nitrate reductase from the Antarctic bacterium Shewanella gelidimarina. Biochemical and Biophysical Research Communications, 414(4), 783-788. [More Information]
  • Groebler, L., Liu, J., Shanu, A., Codd, R., Witting, P. (2011). Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl) carboxamide in a cell model of myoglobinuria. Biochemical Journal, 435(3), 669-677. [More Information]
  • Pakchung, A., Soe, C., Codd, R. (2011). Complexes Formed in Solution Between Vanadium (IV)/(V) and the Cyclic Dihydroxamic Acid Putrebactin or Linear Suberodihydroxamic Acid. Inorganic Chemistry, 50(13), 5978-5989. [More Information]
  • Liu, J., Obando Gutierrez, D., Liao, V., Lifa, T., Codd, R. (2011). The many faces of the adamantyl group in drug design. European Journal of Medicinal Chemistry, 46(6), 1949-1963. [More Information]
  • Wubben, J., Dogovski, C., Dobson, R., Codd, R., Gerrard, J., Parker, M., Perugini, M. (2010). Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66(pt 11), 1511-1516. [More Information]
  • Liu, J., Obando Gutierrez, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010). Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of Medicinal Chemistry, 53(3), 1370-1382. [More Information]
  • Simpson, P., McKinzie, A., Codd, R. (2010). Resolution of two native monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes. Biochemical and Biophysical Research Communications, 398(1), 13-18. [More Information]
  • Fainerman-Melnikova, M., Clegg, J., Pakchung, A., Jensen, P., Codd, R. (2010). Structural diversity of complexes between Cu(II) or Ni(II) and endocyclic oxygen- or nitrogen-containing ligands: Synthesis, X-ray structure determinations and circular dichroism spectra. CrystEngComm, 12(12), 4217-4225. [More Information]
  • Simpson, P., Richardson, D., Codd, R. (2010). The periplasmic nitrate reductase in Shewanella:  The resolution, distribution and functional implications of two NAP isoforms, NapEDABC and NapDAGHB. Microbiology, 156(2), 302-312. [More Information]
  • Liu, J., Clegg, J., Codd, R. (2009). 2,5-Dioxopyrrolidin-1-yl adamantane-1-carboxylate. Acta Crystallographica. Section E: Structure Reports Online, E65, o1740-o1741.
  • Liu, J., Clegg, J., Codd, R. (2009). Methyl 3-[(1adamantylcarbonyloxy)-aminocarbonyl] propanoate. Acta Crystallographica. Section E: Structure Reports Online, E65, o1752-o1743.
  • Codd, R., Braich, N., Liu, J., Soe, C., Pakchung, A. (2009). Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A. The International Journal of Biochemistry and Cell Biology, 41(4), 736-739. [More Information]
  • Braich, N., Codd, R. (2008). Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(III)-binding metabolites directly from bacterial culture supernatants. The Analyst, 2008 (7), 877-880. [More Information]
  • Pakchung, A., Soe, C., Codd, R. (2008). Studies of iron-uptake mechanisms in two bacterial species of the Shewanella Genus adapted to middle-range (Shewanella putrefaciens) or Antarctic (Shewanella gelidimarina) temperatures. Chemistry and Biodiversity, 5(10), 2113-2123. [More Information]
  • Codd, R. (2008). Traversing the coordination chemistry and chemical biology of hydroxamic acids. Coordination Chemistry Reviews, 252, 1387-1408. [More Information]
  • Fainerman-Melnikova, M., Clegg, J., Codd, R. (2006). Aqua[bis(2-pyridylmethyl)amine][chelidonato(1.5-)]-copper(II) chelidonate(0.5–) monohydrate. Acta Crystallographica. Section E: Structure Reports Online, E62(12), m3582-m3584.
  • Codd, R., Lay, P., Tsibakhashvili, N., Kalabegishvili, T., Murusidze, I., Holman, H. (2006). Chromium(V) complexes generated in Arthrobacter oxydans by simulation analysis of EPR spectra. Journal of Inorganic Biochemistry, 100(11), 1827-1833. [More Information]
  • Pakchung, A., Simpson, P., Codd, R. (2006). Life on earth. Extremophiles continue to move the goal posts. Environmental Chemistry, 3(2), 77-93.
  • Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
  • Fainerman-Melnikova, M., Szabo-Planka, T., Rockenbauer, A., Codd, R. (2005). Coordination modes between copper(II) and N-acetylneuraminic (sialic) acid from a 2D-simulation analysis of EPR spectra. Implications for copper mediation of sialoglycoconjugate chemistry relevant to human biology. Inorganic Chemistry, 44(7), 2531-2543. [More Information]
  • Codd, R. (2004). Metalloglycomics: a new perspective upon competitive metal-carbohydrate binding using EPR spectroscopy. Chemical Communications, 2004 (23), 2653-2655.
  • Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055.
  • Codd, R., Lay, P. (2003). Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (Sialic) acids: an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI). Chemical Research in Toxicology, 16(7), 881-892.
  • Codd, R., Irwin, J., Lay, P. (2003). Sialoglycoprotein and carbohydrate complexes in chromium toxicity. Current Opinion In Chemical Biology, 7, 213-219.
  • Raishbrook, S., Turner, P., Codd, R. (2002). A potential synthon for models of vanadium haloperoxidase: (3,5-dimethylpyrazole)-bis[2-hydroxy-2-methylbutanoato(1-)]-oxovanadium(IV). Acta Crystallographica. Section E: Structure Reports Online, E58(12), m737-m739.
  • Codd, R., Astashkin, A., Pacheco, A., Raitsimring, A., Enemark, J. (2002). Pulsed ELDOR spectroscopy of the Mo(V)/Fe(III) state of sulfite oxidase prepared by one-electron reduction with Ti(III) citrate. Journal of Biological Inorganic Chemistry, 7(3), 338-350. [More Information]
  • Codd, R., Lay, P. (2001). Chromium(V)-sialic (neuraminic) acid species are formed from mixtures of chromium(VI) and saliva. Journal of the American Chemical Society, 123, 11799-11800.
  • Codd, R., Dillon, C., Levina, A., Lay, P. (2001). Studies on the genotoxicity of chromium: From the test tube to the cell. Coordination Chemistry Reviews, 216-217(3), 537-582.
  • Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

2016

  • Telfer, T., Gotsbacher, M., Soe, C., Codd, R. (2016). Mixing Up the Pieces of the Desferrioxamine B Jigsaw Defines the Biosynthetic Sequence Catalyzed by DesD. ACS Chemical Biology, 11(5), 1452-1462. [More Information]

2015

  • Lifa, T., Tieu, W., Hocking, R., Codd, R. (2015). Forward and reverse (Retro) Iron(III) or gallium(III) desferrioxamine e and ring-expanded analogues prepared using metal-templated synthesis from endo -hydroxamic acid monomers. Inorganic Chemistry, 54(7), 3573-3583. [More Information]
  • Locock, K., Tran, H., Codd, R., Allan, R. (2015). Hands-On Approach to Structure Activity Relationships: The Synthesis, Testing, and Hansch Analysis of a Series of Acetylcholineesterase Inhibitors. Journal of Chemical Education, 92(10), 1745-1750. [More Information]
  • Nakano, I., Soe, C., Codd, R. (2015). Isolation of doxorubicin from a bacterial culture using immobilised metal ion affinity chromatography. RSC Advances, 5(58), 46437-46442. [More Information]
  • Gu, J., Codd, R. (2015). The resolution of two clinical agents, bleomycin and desferrioxamine B, from a Streptomyces verticillus fermentation mixture using multi-dimensional immobilised metal ion affinity chromatography. RSC Advances, 5(5), 3443-3453. [More Information]

2014

  • Soe, C., Pakchung, A., Codd, R. (2014). Dinuclear [(VVO(putrebactin))2(m-OCH3)2] formed in solution as established from LC-MS measurements using 50V-enriched V2O5. Inorganic Chemistry, 53(11), 5852-5861. [More Information]
  • Codd, R., Gu, J., Ejje, N., Lifa, T. (2014). New Applications of Immobilized Metal Ion Affinity Chromatography in Chemical Biology. In Gilles Gasser (Eds.), Inorganic Chemical Biology: Principles, Techniques and Applications, (pp. 1-35). Chichester: John Wiley & Sons.
  • Soe, C., Codd, R. (2014). Unsaturated Macrocyclic Dihydroxamic Acid Siderophores Produced by Shewanella putrefaciens Using Precursor-Directed Biosynthesis. ACS Chemical Biology, 9(4), 945-956. [More Information]

2013

  • Liddell, J., Obando, D., Liu, J., Ganio, G., Volitakis, I., San Mok, S., Crouch, P., White, A., Codd, R. (2013). Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease. Free Radical Biology and Medicine, 60, 147-156. [More Information]
  • Pakchung, A., Lifa, T., Codd, R. (2013). Solution species of Fe(III), Ga(III), In(III) or Ln(III) and suberodihydroxamic acid from electrospray ionization mass spectrometry. RSC Advances, 3(36), 16051-16059. [More Information]
  • Ejje, N., Soe, C., Gu, J., Codd, R. (2013). The variable hydroxamic acid siderophore metabolome of the marine actinomycete Salinispora tropica CNB-440. Metallomics, 5(11), 1519-1528. [More Information]

2012

  • Liao, V., Liu, T., Codd, R. (2012). Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: Attenuation of potency through resonance effects. Bioorganic & Medicinal Chemistry Letters, 22(19), 6200-6204. [More Information]
  • Ejje, N., Lacey, E., Codd, R. (2012). Analytical-scale purification of trichostatin A from bacterial culture in a single step and with high selectivity using immobilised metal affinity chromatography. RSC Advances, 2(1), 333-337. [More Information]
  • Lifa, T., Ejje, N., Codd, R. (2012). Coordinate-bond-dependent solid-phase organic synthesis of biotinylated desferrioxamine B: a new route for metal-specific probes. Chemical Communications, 48(14), 2003-2005. [More Information]
  • Gu, J., Codd, R. (2012). Copper(II)-based metal affinity chromatography for the isolation of the anticancer agent bleomycin from Streptomyces verticillus culture. Journal of Inorganic Biochemistry, 115(198), 198-203. [More Information]
  • Soe, C., Pakchung, A., Codd, R. (2012). Directing the Biosynthesis of Putrebactin or Desferrioxamine B in Shewanella putrefaciens through the Upstream Inhibition of Ornithine Decarboxylase. Chemistry and Biodiversity, 9(9), 1880-1890. [More Information]
  • Hare, N., Soe, C., Rose, B., Harbour, C., Codd, R., Manos, J., Cordwell, S. (2012). Proteomics of Pseudomonas aeruginosa Australian Epidemic Strain 1 (AES-1) Cultured under Conditions Mimicking the Cystic Fibrosis Lung Reveals Increased Iron Acquisition via the Siderophore Pyochelin. Journal of Proteome Research, 11(2), 776-795. [More Information]

2011

  • Simpson, P., Codd, R. (2011). Cold adaptation of the mononuclear molybdoenzyme periplasmic nitrate reductase from the Antarctic bacterium Shewanella gelidimarina. Biochemical and Biophysical Research Communications, 414(4), 783-788. [More Information]
  • Groebler, L., Liu, J., Shanu, A., Codd, R., Witting, P. (2011). Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl) carboxamide in a cell model of myoglobinuria. Biochemical Journal, 435(3), 669-677. [More Information]
  • Pakchung, A., Soe, C., Codd, R. (2011). Complexes Formed in Solution Between Vanadium (IV)/(V) and the Cyclic Dihydroxamic Acid Putrebactin or Linear Suberodihydroxamic Acid. Inorganic Chemistry, 50(13), 5978-5989. [More Information]
  • Liu, J., Obando Gutierrez, D., Liao, V., Lifa, T., Codd, R. (2011). The many faces of the adamantyl group in drug design. European Journal of Medicinal Chemistry, 46(6), 1949-1963. [More Information]

2010

  • Wubben, J., Dogovski, C., Dobson, R., Codd, R., Gerrard, J., Parker, M., Perugini, M. (2010). Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66(pt 11), 1511-1516. [More Information]
  • Liu, J., Obando Gutierrez, D., Schipanski, L., Groebler, L., Witting, P., Kalinowski, D., Richardson, D., Codd, R. (2010). Conjugates of Desferrioxamine B (DFOB) with Derivatives of Adamantane or with Orally Available Chelators as Potential Agents for Treating Iron Overload. Journal of Medicinal Chemistry, 53(3), 1370-1382. [More Information]
  • Simpson, P., McKinzie, A., Codd, R. (2010). Resolution of two native monomeric 90 kDa nitrate reductase active proteins from Shewanella gelidimarina and the sequence of two napA genes. Biochemical and Biophysical Research Communications, 398(1), 13-18. [More Information]
  • Fainerman-Melnikova, M., Clegg, J., Pakchung, A., Jensen, P., Codd, R. (2010). Structural diversity of complexes between Cu(II) or Ni(II) and endocyclic oxygen- or nitrogen-containing ligands: Synthesis, X-ray structure determinations and circular dichroism spectra. CrystEngComm, 12(12), 4217-4225. [More Information]
  • Simpson, P., Richardson, D., Codd, R. (2010). The periplasmic nitrate reductase in Shewanella:  The resolution, distribution and functional implications of two NAP isoforms, NapEDABC and NapDAGHB. Microbiology, 156(2), 302-312. [More Information]

2009

  • Liu, J., Clegg, J., Codd, R. (2009). 2,5-Dioxopyrrolidin-1-yl adamantane-1-carboxylate. Acta Crystallographica. Section E: Structure Reports Online, E65, o1740-o1741.
  • Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer.
  • Liu, J., Clegg, J., Codd, R. (2009). Methyl 3-[(1adamantylcarbonyloxy)-aminocarbonyl] propanoate. Acta Crystallographica. Section E: Structure Reports Online, E65, o1752-o1743.
  • Codd, R., Braich, N., Liu, J., Soe, C., Pakchung, A. (2009). Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A. The International Journal of Biochemistry and Cell Biology, 41(4), 736-739. [More Information]

2008

  • Braich, N., Codd, R. (2008). Immobilised metal affinity chromatography for the capture of hydroxamate-containing siderophores and other Fe(III)-binding metabolites directly from bacterial culture supernatants. The Analyst, 2008 (7), 877-880. [More Information]
  • Pakchung, A., Soe, C., Codd, R. (2008). Studies of iron-uptake mechanisms in two bacterial species of the Shewanella Genus adapted to middle-range (Shewanella putrefaciens) or Antarctic (Shewanella gelidimarina) temperatures. Chemistry and Biodiversity, 5(10), 2113-2123. [More Information]
  • Codd, R. (2008). Traversing the coordination chemistry and chemical biology of hydroxamic acids. Coordination Chemistry Reviews, 252, 1387-1408. [More Information]

2006

  • Fainerman-Melnikova, M., Clegg, J., Codd, R. (2006). Aqua[bis(2-pyridylmethyl)amine][chelidonato(1.5-)]-copper(II) chelidonate(0.5–) monohydrate. Acta Crystallographica. Section E: Structure Reports Online, E62(12), m3582-m3584.
  • Codd, R., Lay, P., Tsibakhashvili, N., Kalabegishvili, T., Murusidze, I., Holman, H. (2006). Chromium(V) complexes generated in Arthrobacter oxydans by simulation analysis of EPR spectra. Journal of Inorganic Biochemistry, 100(11), 1827-1833. [More Information]
  • Pakchung, A., Simpson, P., Codd, R. (2006). Life on earth. Extremophiles continue to move the goal posts. Environmental Chemistry, 3(2), 77-93.

2005

  • Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
  • Fainerman-Melnikova, M., Szabo-Planka, T., Rockenbauer, A., Codd, R. (2005). Coordination modes between copper(II) and N-acetylneuraminic (sialic) acid from a 2D-simulation analysis of EPR spectra. Implications for copper mediation of sialoglycoconjugate chemistry relevant to human biology. Inorganic Chemistry, 44(7), 2531-2543. [More Information]

2004

  • Codd, R. (2004). Metalloglycomics: a new perspective upon competitive metal-carbohydrate binding using EPR spectroscopy. Chemical Communications, 2004 (23), 2653-2655.
  • Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055.

2003

  • Codd, R. (2003). Biomolecules from extremophilic life. In Nicholls, Pailthorpe (Eds.), From Zero to Infinity, (pp. 37-48). Sydney: Science Foundation for Physics.
  • Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.
  • Codd, R., Lay, P. (2003). Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (Sialic) acids: an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI). Chemical Research in Toxicology, 16(7), 881-892.
  • Codd, R., Irwin, J., Lay, P. (2003). Sialoglycoprotein and carbohydrate complexes in chromium toxicity. Current Opinion In Chemical Biology, 7, 213-219.

2002

  • Raishbrook, S., Turner, P., Codd, R. (2002). A potential synthon for models of vanadium haloperoxidase: (3,5-dimethylpyrazole)-bis[2-hydroxy-2-methylbutanoato(1-)]-oxovanadium(IV). Acta Crystallographica. Section E: Structure Reports Online, E58(12), m737-m739.
  • Codd, R., Astashkin, A., Pacheco, A., Raitsimring, A., Enemark, J. (2002). Pulsed ELDOR spectroscopy of the Mo(V)/Fe(III) state of sulfite oxidase prepared by one-electron reduction with Ti(III) citrate. Journal of Biological Inorganic Chemistry, 7(3), 338-350. [More Information]

2001

  • Codd, R., Lay, P. (2001). Chromium(V)-sialic (neuraminic) acid species are formed from mixtures of chromium(VI) and saliva. Journal of the American Chemical Society, 123, 11799-11800.
  • Codd, R., Dillon, C., Levina, A., Lay, P. (2001). Studies on the genotoxicity of chromium: From the test tube to the cell. Coordination Chemistry Reviews, 216-217(3), 537-582.

2000

  • Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

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