Dr Renjing Liu

Lab Head
Centenary Institute of Cancer Medicine & Cell Biology
Central Clinical School

Telephone +61 2 9565 6227
Fax +61 2 9565 6101

Map

Biographical details

Dr. Renjing Liu is Head of the Agnes Ginges Laboratory for Diseases of the Aorta at the Centenary Institute. Dr. Liu completed her PhD from the University of Sydney with Prof. David Little at the Children's Hospital at Westmead. She completed two postdoctoral traineeships from Yale University - the first at the Yale Stem Cell Center to understand epigenetic mechanisms regulating myogenesis and generation of induced pluripotent stem cells (iPSC) from one of the pioneers in the field; and the second at the Yale Cardiovascular Research Center to understand the role of DNA demethylation in cardiovascular diseases.

Research interests

Dr. Liu has a strong background and interest in stem cell biology, epigenetic regulation of gene expression and cardiovascular research. The main goal of the Aorta Lab is to identify novel pathways and regulators involved in cardiovascular disease, with a specific focus on epigenetic regulation in cellular plasticity.

Current projects

PhD and Masters projects are currently available for highly motivated students in the following areas:

1. Understanding cellular stemness and their role in cardiovascular diseases.

2. Epigenetic regulation of miRNAs in cardiovascular diseases.

3. Deciphering the role of a novel gene in protecting against aortic aneurysms (in collaboration with Prof. Jennifer Gamble).

4. Modelling and understanding complex human diseases using cellular reprogramming.

Please contact Dr. Renjing Liu for more details.

International links

United States

(Yale University) Yale Cardiovascular Research Center

Selected grants

2015

  • Novel therapy approaches for diabetes and its liver and heart complications; Gorrell M, Keane F, Tu T, Shackel N, Bowen D, Bertolino P, Seth D, Chen J, Cook A, Liu R, Zheng X, Gamble J, McCaughan G; Rebecca L Cooper Medical Research Foundation/Research Support.

2014

  • Identification of a novel biomarker for early prediction of cardiovascular disease events; Liu R; Clive & Vera Ramaciotti Foundation/Establishment Grant.
  • Cardiovascular Disease Genetic Markers Research Project; Liu R; National Australia Bank/Social Grant.
  • Targeting smooth muscle plasticity as a novel treatment for cardiovascular diseases; Liu R; University of Sydney/Early Career Researcher.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Liu, R., Leslie, K., Martin, K. (2015). Epigenetic regulation of smooth muscle cell plasticity. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1849 (4), 448-453. [More Information]
  • Zhou, H., Chen, X., Huang, Q., Liu, R., Zhang, H., Wang, Y., Jin, Y., Liang, X., Lu, L., Xu, Z., et al (2014). AIP1 mediates vascular endothelial cell growth factor receptor-3-dependent angiogenic and lymphangiogenic responses. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(3), 603-615. [More Information]
  • Tang, W., Stitham, J., Jin, Y., Liu, R., Lee, S., Du, J., Atteya, G., Gleim, S., Spollett, G., Martin, K., et al (2014). Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets. Circulation, 129(15), 1598-1609. [More Information]
  • Liu, R., Jin, Y., Tang, W., Qin, L., Zhang, X., Tellides, G., Hwa, J., Yu, J., Martin, K. (2014). Response to letter regarding article, "ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity". Circulation, 130(8), e72. [More Information]
  • Qin, L., Huang, Q., Zhang, H., Liu, R., Tellides, G., Min, W., Yu, L. (2014). SOCS1 prevents graft arteriosclerosis by preserving endothelial cell function. Journal of the American College of Cardiology, 63(1), 21-29. [More Information]
  • Liu, R., Jin, Y., Tang, W., Qin, L., Zhang, X., Tellides, G., Hwa, J., Yu, J., Martin, K. (2013). Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity. Circulation, 128(18), 2047-2057. [More Information]
  • Ding, M., Rzucidlo, E., Davey, J., Xie, Y., Liu, R., Jin, Y., Stavola, L., Martin, K. (2012). Adiponectin in the heart and vascular system. Vitamins and Hormones, 90, 289-319. [More Information]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PloS One, 7(7), 1-17. [More Information]
  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]
  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
  • Gaines, P., Liu, R., Park, I. (2010). Research Highlights. Regenerative Medicine, 5(4), 501-503. [More Information]
  • Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]
  • Lee, A., Kahatapitiya, P., Kramer, B., Joya, J., Hook, J., Liu, R., Schevzov, G., Alexander, I., McCowage, G., Montarras, D., Gunning, P., et al (2009). Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle. Stem Cells: the international journal of cell differentiation and proliferation, 27, 1098-1108. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]

2015

  • Liu, R., Leslie, K., Martin, K. (2015). Epigenetic regulation of smooth muscle cell plasticity. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1849 (4), 448-453. [More Information]

2014

  • Zhou, H., Chen, X., Huang, Q., Liu, R., Zhang, H., Wang, Y., Jin, Y., Liang, X., Lu, L., Xu, Z., et al (2014). AIP1 mediates vascular endothelial cell growth factor receptor-3-dependent angiogenic and lymphangiogenic responses. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(3), 603-615. [More Information]
  • Tang, W., Stitham, J., Jin, Y., Liu, R., Lee, S., Du, J., Atteya, G., Gleim, S., Spollett, G., Martin, K., et al (2014). Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets. Circulation, 129(15), 1598-1609. [More Information]
  • Liu, R., Jin, Y., Tang, W., Qin, L., Zhang, X., Tellides, G., Hwa, J., Yu, J., Martin, K. (2014). Response to letter regarding article, "ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity". Circulation, 130(8), e72. [More Information]
  • Qin, L., Huang, Q., Zhang, H., Liu, R., Tellides, G., Min, W., Yu, L. (2014). SOCS1 prevents graft arteriosclerosis by preserving endothelial cell function. Journal of the American College of Cardiology, 63(1), 21-29. [More Information]

2013

  • Liu, R., Jin, Y., Tang, W., Qin, L., Zhang, X., Tellides, G., Hwa, J., Yu, J., Martin, K. (2013). Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity. Circulation, 128(18), 2047-2057. [More Information]

2012

  • Ding, M., Rzucidlo, E., Davey, J., Xie, Y., Liu, R., Jin, Y., Stavola, L., Martin, K. (2012). Adiponectin in the heart and vascular system. Vitamins and Hormones, 90, 289-319. [More Information]
  • Cairns, D., Liu, R., Sen, M., Canner, J., Schindeler, A., Little, D., Zeng, L. (2012). Interplay of Nkx3.2, Sox9 and Pax3 Regulates Chondrogenic Differentiation of Muscle Progenitor Cells. PloS One, 7(7), 1-17. [More Information]

2011

  • Liu, R., Birke, O., Morse, A., Peacock, L., Mikulec, K., Little, D., Schindeler, A. (2011). Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskeletal Disorders, 12, 288 - 1-288 - 9. [More Information]

2010

  • Schindeler, A., Morse, A., Peacock, L., Mikulec, K., Yu, N., Liu, R., Kijumnuayporn, S., McDonald, M., Baldock, P., Ruys, A., Little, D. (2010). Rapid cell culture and pre-clinical screening of a transforming growth factor-beta (TGF-beta) inhibitor for orthopaedics. BMC Musculoskeletal Disorders, 11(105), 105-1-105-9. [More Information]
  • Gaines, P., Liu, R., Park, I. (2010). Research Highlights. Regenerative Medicine, 5(4), 501-503. [More Information]
  • Liu, R., Schindeler, A., Little, D. (2010). The potential role of muscle in bone repair. Journal of Musculoskeletal and Neuronal Interactions, 10(1), 71-76. [More Information]

2009

  • Lee, A., Kahatapitiya, P., Kramer, B., Joya, J., Hook, J., Liu, R., Schevzov, G., Alexander, I., McCowage, G., Montarras, D., Gunning, P., et al (2009). Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle. Stem Cells: the international journal of cell differentiation and proliferation, 27, 1098-1108. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Schindeler, A., Liu, R., Little, D. (2009). The contribution of different cell lineages to bone repair: exploring a role for muscle stem cells. Differentiation, 77(1), 12-18. [More Information]

To update your profile click here. For support on your academic profile contact .