Associate Professor Richard Payne

BSc Canterbury; PhD Camb
Associate Professor
ARC Future Fellow and Second Year Coordinator

Telephone 61 2 9351 5877
Fax 61 2 9351 3329

Website The Payne Research Group
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Biographical details

Richard J. Payne graduated from the University of Canterbury, New Zealand in 2002. His final year project was supervised by Professor Andrew Abell and involved the synthesis and protein conjugation studies of vitamin K analogues. In 2003 he was awarded a Gates Scholarship to undertake his PhD at the Department of Chemistry, University of Cambridge (Downing College) under the supervision of Professor Chris Abell. His PhD research entailed the design, synthesis and evaluation of inhibitors of enzymes on, and downstream of the shikimate pathway. After a short postdoctoral tenure at the University of Cambridge (Feb-June 2006), Richard moved to The Scripps Research Institute under the auspices of a Lindemann Postdoctoral Fellowship and the guidance of Professor Chi-Huey Wong. Here, he was involved in the development of new methods for the synthesis of glycopeptides and glycoproteins. In 2008 he moved to the University of Sydney where he is currently an Associate Professor in Organic Chemistry and Chemical Biology within the School of Chemistry.

  • BSc (Hons, First Class) University of Canterbury, Christchurch, New Zealand. (1998-2001)
  • PhD (Gates Scholar), University of Cambridge (Downing College), Cambridge, UK. (2003-2006)
  • Research Associate, University of Canterbury, Christchurch, New Zealand. (2001-2002)
  • Postdoctoral Research Associate, University of Cambridge, Cambridge, UK. (2006)
  • Postdoctoral Research Associate (Lindemann Fellow), The Scripps Research Institute, La Jolla, California, USA. (2006-2008)
  • Lecturer, The University of Sydney, (2008 - 2010)
  • Senior Lecturer, The University of Sydney (2011 - 2012)
  • Associate Professor, The University of Sydney (2013 - present)

Research interests

Research in my group is focussed on utilising the tools of chemistry to address problems of biochemical and medicinal significance. Projects are multidisciplinary in nature, involving a combination of solution- and solid-phase organic synthesis, computer-aided drug discovery, compound screening technologies. Current projects include:

  • Rational design, synthesis and evaluation of new anti-infectives. More specifically, we are developing inhibitors that target novel pathways operating in pathogenic bacteria e.g. Mycobacterium tuberculosis (cause of TB) and parasitic organisms e.g. Plasmodium falciparum (cause of malaria).
  • Total synthesis of glycopeptides and glycoproteins of therapeutic interest.
  • Development of glycopeptide-based cancer vaccines.

Teaching and supervision

  • Second Year Coordinator

Current projects

For current research activities and opportunities please visit our home page at http://sydney.edu.au/science/chemistry/~payne/

Awards and honours

  • Royal Australian Chemical Institute Biota Medal for Medicinal Chemistry (2008)
  • New South Wales Young Tall Poppy Award (2010)
  • RACI's 2011 Rennie Memorial Medal (2011)
  • 2012 RACI Organic Chemistry Division Athel Beckwith lectureship (2012)
  • 2013 Tregear Award in Peptide Science
  • 2013 ARC Future Fellowship
  • 2014 Le Fèvre Memorial Prize

Selected grants

2015

  • Discovery of New Tuberculosis Drug Leads Targeting Cell Wall Biosynthesis; Payne R, Britton W, Crick D, West N, Charman S; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • New platform technologies for the chemical synthesis of post-translationally modified proteins; Payne R; Australian Research Council (ARC)/Future Fellowships (FT).
  • Development of Antimalarial Drug Leads; Payne R, Hunt N, McGowan S, Charman S, Rosenthal P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Elucidating the mechanisms and consequences of clinical HIV-1 resistance to the CCR5 antagonist maraviroc; Gorry P, Lee B, Payne R, Ramsland P; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Preparation and Evaluation of Synthetic Self-Adjuvanting Cancer Vaccine Candidates; Payne R; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.
  • HPLC-MS for high throughput drug and protein analysis; Payne R, Kassiou M, Cordwell S, Hibbs D, Groundwater P, Shepherd N; DVC Research/Equipment Grant.
  • Development and Application of New Peptide Ligation Methods for the Synthesis and Structure-Function Studies of Glycoproteins; Payne R, Stone M; Australian Research Council (ARC)/Discovery Projects (DP).
  • The Nanotemper: State-of-the-art instrumentation for the characterization of protein interactions; Payne R, Matthews J, Ataide S, Campbell I, Weiss A, Sunde M, Mackay J; Clive and Vera Ramaciotti Foundations/Awards for Biomedical Research: Major Equipment.
  • Improving subunit vaccines against tuberculosis for pulmonary delivery; Britton W, West N, Payne R, Chan H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Multiangle laser light scattering instrument for protein characterisation; Mackay J, Ataide S, Jormakka M, Ryan R, Matthews J, Shepherd N, Sunde M, Collyer C, Payne R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • Design, development and analysis of new tuberculosis drugs; Payne R, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Regulation of vascular tone by kynurenines; Payne R, Stocker R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Nanoparticle Aerosol Delivery of Novel Tuberculosis Drug Leads; Payne R, Prud'homme R; DVC International/IPDF Grant.
  • A novel pathway for the regulation of vascular tone; Payne R, Stocker R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • New methods for the chemical synthesis of a library of glycopeptide-based tri-component cancer vaccines; Payne R; Australian Research Council (ARC)/Discovery Projects (DP).

2011

  • Development and preclinical testing of novel HIV inhibitors with specific activity against viruses with CCR5- antagonist resistance; Gorry P, Payne R; Australian Centre for Hepatitis and HIV Virology Research (ACH2)/HIV and Hepatitis C Virology and Immunology Research Grants.
  • Preparative High-Performance Liquid Chromatography (HPLC); Payne R, Jolliffe K, Hambley T, Kassiou M, Collins M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • POLARStar Omega; Sunde M, Guss M, Mackay J, Matthews J, Payne R, Cubeddu L; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Design, development and analysis of new tuberculosis drugs; West N, Britton W, Payne R; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Automated Microwave accelerated Solid Phase Peptide Synthesizer; Jolliffe K, Payne R, Hambley T, Mackay J, Sunde M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • NMR Spectroscopy Facilities for the Sydney Region; Jolliffe K, Messerle B, Hambley T, Rendina L, Payne R, Mackay J, Kuchel P, Messerle B, Ball G, Price W, Crossley M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Inhibition of Siderophore Biosynthesis for Tuberculosis Drug Discovery; Payne R, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Solid-Phase Synthesis of Sulfopeptides for Evaluation of Chemokine-Receptor Recognition; Payne R, Stone M; Australian Research Council (ARC)/Discovery Projects (DP).

2009

  • Chemical synthesis of cancer-associated glycoproteins; Payne R; Australian Research Council (ARC)/Discovery Projects (DP).

Selected publications

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Book Chapters

  • Bennett, C., Payne, R., Koeller, K., Wong, C. (2008). Biologically relevant glycopeptides: Synthesis and applications. In Bertram O Fraser-Reid, Kuniaki Tatsuta, Joachim Thiem (Eds.), Glycoscience. Chemistry and Chemical Biology, (pp. 1795-1857). New York, USA: Springer.

Journals

  • Maghzal, G., Cergol, K., Shengule, S., Suarna, C., Newington, D., Kettle, A., Payne, R., Stocker, R. (2014). Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium. The Journal of Biological Chemistry, 289(9), 5580-5595. [More Information]
  • Malins, L., Cergol, K., Payne, R. (2014). Chemoselective sulfenylation and peptide ligation at tryptophan. Chemical Science, 5(1), 260-266. [More Information]
  • Huma, Z., Ludeman, J., Wilkinson, B., Payne, R., Stone, M. (2014). NMR characterization of cooperativity: fast ligand binding coupled to slow protein dimerization. Chemical Science, 5(7), 2783-2788. [More Information]
  • Cergol, K., Thompson, R., Malins, L., Turner, P., Payne, R. (2014). One-pot peptide ligation-desulfurization at glutamate. Organic Letters, 16(1), 290-293. [More Information]
  • Malins, L., Mitchell, N., Payne, R. (2014). Peptide ligation chemistry at selenol amino acids. Journal of Peptide Science, 20(2), 64-77. [More Information]
  • Malins, L., Payne, R. (2014). Recent extensions to native chemical ligation for the chemical synthesis of peptides and proteins. Current Opinion In Chemical Biology, 22, 70-78. [More Information]
  • Liu, X., Malins, L., Roche, M., Sterjovski, J., Duncan, R., Garcia, M., Barnes, N., Anderson, D., Stone, M., Gorry, P., Payne, R. (2014). Site-selective solid-phase synthesis of a CCR5 sulfopeptide library to interrogate HIV binding and entry. ACS Chemical Biology, 9(9), 2074-2081. [More Information]
  • McDonald, D., Wilkinson, B., Corcilius, L., Thaysen-Andersen, M., Byrne, S., Payne, R. (2014). Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates. Chemical Communications, 50(71), 10273-10276. [More Information]
  • Thompson, R., Collin, F., Maxwell, A., Jolliffe, K., Payne, R. (2014). Synthesis of full length and truncated microcin B17 analogues as DNA gyrase poisons. Organic and Biomolecular Chemistry, 12(10), 1570-1578. [More Information]
  • Hsieh, Y., Wijeyewickrema, L., Wilkinson, B., Pike, R., Payne, R. (2014). Total synthesis of homogeneous variants of hirudin P6: A post-translationally modified anti-thrombotic leech-derived protein. Angewandte Chemie (International Edition), 53(15), 3947-3951. [More Information]
  • Santhakumar, G., Payne, R. (2014). Total synthesis of polydiscamides B, C, and D via a convergent native chemical ligation-oxidation strategy. Organic Letters, 16(17), 4500-4503. [More Information]
  • Thompson, R., Liu, X., Alonso-Garcia, N., Barbosa Pereira, P., Jolliffe, K., Payne, R. (2014). Trifluoroethanethiol: An additive for efficient one-pot peptide ligation-desulfurization chemistry. Journal of the American Chemical Society, 136(23), 8161-8164. [More Information]
  • Roche, M., Salimi, H., Duncan, R., Wilkinson, B., Chikere, K., Moore, M., Webb, N., Zappi, H., Sterjovski, J., Flynn, J., Payne, R., et al (2013). A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology, 10(43), 1-20. [More Information]
  • Thompson, R., Chan, B., Radom, L., Jolliffe, K., Payne, R. (2013). Chemoselective peptide ligation-desulfurization at aspartate. Angewandte Chemie (International Edition), 52(37), 9723-9727. [More Information]
  • Collin, F., Thompson, R., Jolliffe, K., Payne, R., Maxwell, A. (2013). Fragments of the bacterial toxin microcin B17 as gyrase poisons. PLoS One, 8(4), 1-9. [More Information]
  • Tran, A., Wen, D., West, N., Baker, E., Britton, W., Payne, R. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11(46), 8113-8126. [More Information]
  • Malins, L., Cergol, K., Payne, R. (2013). Peptide ligation-desulfurization chemistry at arginine. ChemBioChem: a European journal of chemical biology, 14(5), 559-563. [More Information]
  • Corcilius, L., Payne, R. (2013). Stereoselective synthesis of sialylated tumor-associated glycosylamino acids. Organic Letters, 15(22), 5794-5797. [More Information]
  • Ziarek, J., Getschman, A., Butler, S., Taleski, D., Stephens, B., Kufareva, I., Handel, T., Payne, R., Volkman, B. (2013). Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chemical Biology, 8(9), 1955-1963. [More Information]
  • Al Sheikha, D., Wilkinson, B., Santhakumar, G., Thaysen-Andersen, M., Payne, R. (2013). Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy. Organic and Biomolecular Chemistry, 11(36), 6090-6096. [More Information]
  • Corcilius, L., Santhakumar, G., Stone, R., Capicciotti, C., Joseph, S., Matthews, J., Ben, R., Payne, R. (2013). Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules. Bioorganic and Medicinal Chemistry, 21(12), 3569-3581. [More Information]
  • Payne, R. (2013). Total Synthesis of Erythropoietin through the Development and Exploitation of Enabling Synthetic Technologies. Angewandte Chemie (International Edition), 52(2), 505-507. [More Information]
  • Giltrap, A., Cergol, K., Pang, A., Britton, W., Payne, R. (2013). Total Synthesis of Fellutamide B and Deoxy-Fellutamides B, C, and D. Marine Drugs, 11(7), 2382-2397. [More Information]
  • Tan, J., Ludeman, J., Wedderburn, J., Canals, M., Hall, P., Butler, S., Taleski, D., Christopoulos, A., Hickey, M., Payne, R., et al (2013). Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1). Journal of Biological Chemistry, 288(14), 10024-10034. [More Information]
  • Tan, J., Canals, M., Ludeman, J., Wedderburn, J., Boston, C., Butler, S., Carrick, A., Parody, T., Taleski, D., Christopoulos, A., Payne, R., et al (2012). Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1). Journal of Biological Chemistry, 287(18), 14692-14702. [More Information]
  • Hsieh, Y., Taleski, D., Wilkinson, B., Wijeyewickrema, L., Adams, T., Pike, R., Payne, R. (2012). Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin. Chemical Communications, 48(10), 1547-1549. [More Information]
  • Tran, A., West, N., Britton, W., Payne, R. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. ChemMedChem: chemistry enabling drug discovery, 7(6), 1031-1043. [More Information]
  • Duncan, R., Mohlin, F., Taleski, D., Coetzer, T., Huntington, J., Payne, R., Blom, A., Pike, R., Wijeyewickrema, L. (2012). Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. Journal of Immunology, 189(5), 2365-2373. [More Information]
  • Bakmiwewa, S., Fatokun, A., Tran, A., Payne, R., Hunt, N., Ball, H. (2012). Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorganic & Medicinal Chemistry Letters, 22(24), 7641-7646. [More Information]
  • Chi, G., Manos-Turvey, A., O'Connor, P., Johnston, J., Evans, G., Baker, E., Payne, R., Lott, J., Bulloch, E. (2012). Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry, 51(24), 4868-4879. [More Information]
  • Maghzal, G., Cergol, K., Suarna, C., Newington, D., Kettle, A., Payne, R., Stocker, R. (2012). In vivo detection of myeloperoxidase activity by LC/MS analysis of 2-chloro-ethidium, a novel product formed from the reaction of hydroethidine with hypochlorous acid and chloramines. Free Radical Biology and Medicine, 53(supplement 1), s223-s224. [More Information]
  • Andrews, D., Heazlewood, B., Maccarone, A., Conroy, T., Payne, R., Jordan, M., Kable, S. (2012). Photo-tautomerization of acetaldehyde to vinyl alcohol: A potential route to tropospheric acids. Science, 337(6099), 1203-1206. [More Information]
  • Manos-Turvey, A., Cergol, K., Salam, N., Bulloch, E., Chi, G., Pang, A., Britton, W., West, N., Baker, E., Lott, J., Payne, R. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10(46), 9223-9236. [More Information]
  • Wilkinson, B., Day, S., Chapman, R., Perrier, S., Apostolopoulos, V., Payne, R. (2012). Synthesis and immunological evaluation of self-assembling and self-adjuvanting tricomponent glycopeptide cancer-vaccine candidates. Chemistry: A European Journal, 18(51), 16540-16548. [More Information]
  • Graham, M., Stone, R., Robinson, P., Payne, R. (2012). Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked beta-N-acetylglucosaminyl-6-phosphate modification. Organic and Biomolecular Chemistry, 10(13), 2545-2551. [More Information]
  • Malins, L., Payne, R. (2012). Synthesis and utility of beta-selenol-phenylalanine for native chemical ligation - deselenization chemistry. Organic Letters, 14(12), 3142-3145. [More Information]
  • Hsieh, Y., Wilkinson, B., O'Connell, M., Mackay, J., Matthews, J., Payne, R. (2012). Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Organic Letters, 14(7), 1910-1913. [More Information]
  • Thompson, R., Payne, R., Jolliffe, K. (2012). Total Synthesis of Cyclocitropside A and Its Conversion to Cyclocitropsides B and C via Asparagine Deamidation. Organic Letters, 14(19), 5110-5113. [More Information]
  • Wilkinson, B., Stone, R., Capicciotti, C., Thaysen-Andersen, M., Matthews, J., Packer, N., Ben, R., Payne, R. (2012). Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins. Angewandte Chemie (International Edition), 51(15), 3606-3610. [More Information]
  • Taleski, D., Butler, S., Stone, M., Payne, R. (2011). Divergent and Site-Selective Solid-Phase Synthesis of Sulfopeptides. Chemistry - An Asian Journal, 6(6), 1316-1320. [More Information]
  • West, N., Cergol, K., Xue, M., Randall, E., Britton, W., Payne, R. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47(18), 5166-5168. [More Information]
  • Thomas, G., Hsieh, Y., Chun, C., Cai, Z., Reimers, J., Payne, R. (2011). Peptide ligations accelerated by N-terminal aspartate and glutamate residues. Organic Letters, 13(18), 4770-4773. [More Information]
  • Wilkinson, B., Day, S., Malins, L., Apostolopoulos, V., Payne, R. (2011). Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam(3)CysSer. Angewandte Chemie (International Edition), 50(7), 1635-1639. [More Information]
  • Kakwere, H., Payne, R., Jolliffe, K., Perrier, S. (2011). Self-assembling macromolecular chimeras: Controlling fibrillization of a β-sheet forming peptide by polymer conjugation. Soft Matter, 7(8), 3754-3757. [More Information]
  • Thaysen-Andersen, M., Wilkinson, B., Payne, R., Packer, N. (2011). Site-specific characterisation of densely O-glycosylated mucin-type peptides using electron transfer dissociation ESI-MS/MS. Electrophoresis, 32(24), 3536-3545. [More Information]
  • Dias, M., Snee, W., Bromfield, K., Payne, R., Palaninathan, S., Ciulli, A., Howard, N., Abell, C., Sacchettini, J., Blundell, T. (2011). Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochemical Journal, 436(3), 729-739. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and Evaluation of Potent Ene-yne inhibitors of type II Dehydroquinases as Tuberculosis Drug Leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Wilkinson, B., Chun, C., Payne, R. (2011). Synthesis of MUC1 Glycopeptide Thioesters and Ligation Via Direct Aminolysis. Biopolymers : Peptide Science, 96(2), 137-146. [More Information]
  • Chim, N., Habel, J., Johnston, J., Krieger, I., Miallau, L., Sankaranarayanan, R., Morse, R., Bruning, J., Swanson, S., Kim, H., Payne, R., Manos-Turvey, A., et al (2011). The TB Structural Genomics Consortium: A decade of progress. Tuberculosis, 91(2), 155-172. [More Information]
  • Thompson, R., Jolliffe, K., Payne, R. (2011). Total Synthesis of Microcin B17 via a Fragment Condensation Approach. Organic Letters, 13(4), 680-683. [More Information]
  • Conroy, T., Guo, J., Linington, R., Hunt, N., Payne, R. (2011). Total synthesis, Stereochemical Assignment, and Antimalarial Activity of Gallinamide A. Chemistry: A European Journal, 17(48), 13544-13552. [More Information]
  • Zhu, J., Millard, C., Ludeman, J., Simpson, L., Clayton, D., Payne, R., Widlanski, T., Stone, M. (2011). Tyrosine Sulfation Influences the Chemokine Binding Selectivity of Peptides Derived from Chemokine Receptor CCR3. Biochemistry, 50(9), 1524-1534. [More Information]
  • Payne, R., Wong, C. (2010). Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins. Chemical Communications, 46(1), 21-43. [More Information]
  • Holt, D., Payne, R., Chow, W., Abell, C. (2010). Fluorosurfactants for microdroplets: Interfacial tension analysis. Journal of Colloid and Interface Science, 350(1), 205-211. [More Information]
  • Payne, R., Bulloch, E., Kerbarh, O., Abell, C. (2010). Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues. Organic and Biomolecular Chemistry, 8(15), 3534-3542.
  • Manos-Turvey, A., Bulloch, E., Rutledge, P., Baker, E., Lott, J., Payne, R. (2010). Inhibition studies of mycobacterium tuberculosis salicylate synthase (Mbtl). ChemMedChem: chemistry enabling drug discovery, 5(7), 1067-1079. [More Information]
  • Kakwere, H., Chun, C., Jolliffe, K., Payne, R., Perrier, S. (2010). Polymer-peptide chimeras for the multivalent display of immunogenic peptides. Chemical Communications, 46(13), 2188-2190. [More Information]
  • Tran, A., Cergol, K., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2010). Rapid assembly of potent type II dehydroquinase inhibitors via "click" chemistry. MedChemComm (Medicinal Chemistry Communications), 1(4), 271-275.
  • Wilkinson, B., Malins, L., Chun, C., Payne, R. (2010). Synthesis of MUC1-lipopeptide chimeras. Chemical Communications, 46(34), 6249-6251.
  • Conroy, T., Jolliffe, K., Payne, R. (2010). Synthesis of N-linked glycopeptides via solid-phase aspartylation. Organic and Biomolecular Chemistry, 8(16), 3723-3733.
  • Holt, D., Payne, R., Abell, C. (2010). Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams. Journal of Fluorine Chemistry, 131(3), 398-407. [More Information]
  • Conroy, T., Guo, J., Hunt, N., Payne, R. (2010). Total synthesis and antimalarial activity of symplostatin 4. Organic Letters, 12(23), 5576-5579. [More Information]
  • Conroy, T., Jolliffe, K., Payne, R. (2009). Efficient use of the Dmab protecting group: Applications for the solid-phase synthesis of N-linked glycopeptides. Organic and Biomolecular Chemistry, 7(11), 2255-2258.
  • Thomas, G., Payne, R. (2009). Phosphate-assisted peptide ligation. Chemical Communications, 2009 (28), 4260-4262.
  • Payne, R., Bulloch, E., Toscano, M., Jones, M., Kerbarh, O., Abell, C. (2009). Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. Organic and Biomolecular Chemistry, 7(11), 2421-2429.
  • Garner, J., Jolliffe, K., Harding, M., Payne, R. (2009). Synthesis of homogeneous antifreeze glycopeptides via a ligation-desulfurisation strategy. Chemical Communications, 45(45), 6925-6927.
  • Chun, C., Payne, R. (2009). Synthesis of MUC1 peptide and glycopeptide dendrimers. Australian Journal of Chemistry: an international journal for chemical science, 62(10), 1339-1343.
  • Thordarson, P., Payne, R. (2009). The inaugural Australian workshop on bioconjugate chemistry, UNSW 2008. Australian Journal of Chemistry: an international journal for chemical science, 62(10), 1318-1319.
  • Payne, R., Ficht, S., Greenberg, W., Wong, C. (2008). Cysteine-free peptide and glycopeptide ligation by direct aminolysis. Angewandte Chemie (International Edition), 47(23), 4411-4415. [More Information]
  • Ficht, S., Payne, R., Guy, R., Wong, C. (2008). Solid-phase synthesis of peptide and glycopeptide thioesters through side-chain-anchoring strategies. Chemistry: A European Journal, 14(12), 3620-3629. [More Information]
  • Bennett, C., Dean, S., Payne, R., Ficht, S., Brik, A., Wong, C. (2008). Sugar-assisted glycopeptide ligation with complex oligosaccharides: Scope and limitations. Journal of the American Chemical Society, 130(36), 11945-11952.
  • Payne, R., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A., Lapthorn, A., Abell, C. (2007). Design, Synthesis, and Structural Studies on Potent Biaryl Inhibitors of Type II Dehydroquinases. ChemMedChem: chemistry enabling drug discovery, 2(7), 1010-1013. [More Information]
  • Payne, R., Ficht, S., Tang, S., Brik, A., Yang, Y., Case, D., Wong, C. (2007). Extended Sugar-Assisted Glycopeptide Ligations: Development, Scope, and Applications. Journal of the American Chemical Society, 129(44), 13527-13536.
  • Abell, A., Jones, M., Neffe, A., Aitken, S., Cain, T., Payne, R., McNabb, S., Coxon, J., Stuart, B., Pearson, D., et al (2007). Investigation into the P3 Binding Domain of m-Calpain Using Photoswitchable Diazo- and Triazene-dipeptide Aldehydes: New Anticataract Agents. Journal of Medicinal Chemistry, 50(12), 2916-2920.
  • Toscano, M., Payne, R., Chiba, A., Kerbarh, O., Abell, C. (2007). Nanomolar Inhibition of Type II Dehydroquinase Based on the Enolate Reaction Mechanism. ChemMedChem: chemistry enabling drug discovery, 2(1), 101-112. [More Information]
  • Payne, R., Peyrot, F., Kerbarh, O., Abell, A., Abell, C. (2007). Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors. ChemMedChem: chemistry enabling drug discovery, 2(7), 1015-1029. [More Information]
  • Ficht, S., Payne, R., Brik, A., Wong, C. (2007). Second-Generation Sugar-Assisted Ligation: A Method for the Synthesis of Cysteine-Containing Glycopeptides. Angewandte Chemie (International Edition), 46(31), 5975-5979. [More Information]
  • Payne, R., Bulloch, E., Abell, A., Abell, C. (2005). Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic and Biomolecular Chemistry, 3(20), 3629-3635.
  • Payne, R., Kerbarh, O., Miguel, R., Abell, A., Abell, C. (2005). Inhibition studies on salicylate synthase. Organic and Biomolecular Chemistry, 3(10), 1825-1827.
  • Payne, R., Edmonds, M. (2005). Isolation of Shikimic Acid from Star Aniseed. Journal of Chemical Education, 82(4), 599-600.
  • Kerbarh, O., Bulloch, E., Payne, R., Sahr, T., Rebeille, F., Abell, C. (2005). Mechanistic and inhibition studies of chorismate-utilizing enzymes. Biochemical Society Transactions, 33(4), 763-766.
  • Payne, R., Brown, K., Coxon, J., Morton, J., Lee, H., Abell, A. (2004). Peptidic aldehydes based on alpha- and beta-amino acids: Synthesis, inhibition of m-calpain, and anti-cataract properties. Australian Journal of Chemistry: an international journal for chemical science, 57(9), 877-884.
  • Payne, R., Daines, A., Clark, B., Abell, A. (2004). Synthesis and protein conjugation studies of vitamin K analogues. Bioorganic and Medicinal Chemistry, 12(22), 5785-5791. [More Information]
  • de Zwart, F., Slow, S., Payne, R., Lever, M., George, P., Gerrard, J., Chambers, S. (2003). Glycine betaine and glycine betaine analogues in common foods. Food Chemistry, 83(2), 197-204.
  • Daines, A., Payne, R., Humphries, M., Abell, A. (2003). The Synthesis of Naturally Occurring Vitamin K and Vitamin K Analogues. Current Organic Chemistry, 7(16), 1625-1634.
  • Payne, R., Abell, A. (2002). Protein binding studies of vitamin K analogues for use in an immunological assay. Chemistry in New Zealand, 66(1), 16-26.

Conferences

  • Payne, R. (2009). Inhibition of Shikimate pathway enzymes as novel antibacterial leads (Biota Medal Lecture). 7th AFMC International Medicinal Chemistry Symposium, N/A: N/A.
  • Payne, R. (2009). Ligation-based assembly of glycopeptides and glycoproteins. Seminar, School of Chemistry, Monash University, N/A: N/A.
  • Payne, R. (2009). New ligation strategies for the synthesis of peptides bearing post-translational modifications (Invited lecture). 8th Australian Peptide Conference.
  • Payne, R. (2009). New strategies for the synthesis of glycopeptides and glycoproteins. Seminar, School of Chemistry, University of New South Wales, N/A: N/A.
  • Payne, R. (2009). New strategies for the synthesis of post-translationally modified peptides and proteins. Seminar, School of Chemistry and Physics, University of Adelaide, N/A: N/A.
  • Payne, R. (2009). New strategies for the synthesis of post-translationally modified peptides and proteins. Chemistry Seminar program 2009 - School of Chemistry @ UOW, N/A: N/A.
  • Payne, R. (2009). Synthesis of N-linked glycopeptides via solid-phase aspartylation (Invited lecture). Modern Solid Phase Peptide Synthesis and its Applications.

2014

  • Maghzal, G., Cergol, K., Shengule, S., Suarna, C., Newington, D., Kettle, A., Payne, R., Stocker, R. (2014). Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium. The Journal of Biological Chemistry, 289(9), 5580-5595. [More Information]
  • Malins, L., Cergol, K., Payne, R. (2014). Chemoselective sulfenylation and peptide ligation at tryptophan. Chemical Science, 5(1), 260-266. [More Information]
  • Huma, Z., Ludeman, J., Wilkinson, B., Payne, R., Stone, M. (2014). NMR characterization of cooperativity: fast ligand binding coupled to slow protein dimerization. Chemical Science, 5(7), 2783-2788. [More Information]
  • Cergol, K., Thompson, R., Malins, L., Turner, P., Payne, R. (2014). One-pot peptide ligation-desulfurization at glutamate. Organic Letters, 16(1), 290-293. [More Information]
  • Malins, L., Mitchell, N., Payne, R. (2014). Peptide ligation chemistry at selenol amino acids. Journal of Peptide Science, 20(2), 64-77. [More Information]
  • Malins, L., Payne, R. (2014). Recent extensions to native chemical ligation for the chemical synthesis of peptides and proteins. Current Opinion In Chemical Biology, 22, 70-78. [More Information]
  • Liu, X., Malins, L., Roche, M., Sterjovski, J., Duncan, R., Garcia, M., Barnes, N., Anderson, D., Stone, M., Gorry, P., Payne, R. (2014). Site-selective solid-phase synthesis of a CCR5 sulfopeptide library to interrogate HIV binding and entry. ACS Chemical Biology, 9(9), 2074-2081. [More Information]
  • McDonald, D., Wilkinson, B., Corcilius, L., Thaysen-Andersen, M., Byrne, S., Payne, R. (2014). Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates. Chemical Communications, 50(71), 10273-10276. [More Information]
  • Thompson, R., Collin, F., Maxwell, A., Jolliffe, K., Payne, R. (2014). Synthesis of full length and truncated microcin B17 analogues as DNA gyrase poisons. Organic and Biomolecular Chemistry, 12(10), 1570-1578. [More Information]
  • Hsieh, Y., Wijeyewickrema, L., Wilkinson, B., Pike, R., Payne, R. (2014). Total synthesis of homogeneous variants of hirudin P6: A post-translationally modified anti-thrombotic leech-derived protein. Angewandte Chemie (International Edition), 53(15), 3947-3951. [More Information]
  • Santhakumar, G., Payne, R. (2014). Total synthesis of polydiscamides B, C, and D via a convergent native chemical ligation-oxidation strategy. Organic Letters, 16(17), 4500-4503. [More Information]
  • Thompson, R., Liu, X., Alonso-Garcia, N., Barbosa Pereira, P., Jolliffe, K., Payne, R. (2014). Trifluoroethanethiol: An additive for efficient one-pot peptide ligation-desulfurization chemistry. Journal of the American Chemical Society, 136(23), 8161-8164. [More Information]

2013

  • Roche, M., Salimi, H., Duncan, R., Wilkinson, B., Chikere, K., Moore, M., Webb, N., Zappi, H., Sterjovski, J., Flynn, J., Payne, R., et al (2013). A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology, 10(43), 1-20. [More Information]
  • Thompson, R., Chan, B., Radom, L., Jolliffe, K., Payne, R. (2013). Chemoselective peptide ligation-desulfurization at aspartate. Angewandte Chemie (International Edition), 52(37), 9723-9727. [More Information]
  • Collin, F., Thompson, R., Jolliffe, K., Payne, R., Maxwell, A. (2013). Fragments of the bacterial toxin microcin B17 as gyrase poisons. PLoS One, 8(4), 1-9. [More Information]
  • Tran, A., Wen, D., West, N., Baker, E., Britton, W., Payne, R. (2013). Inhibition studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Organic and Biomolecular Chemistry, 11(46), 8113-8126. [More Information]
  • Malins, L., Cergol, K., Payne, R. (2013). Peptide ligation-desulfurization chemistry at arginine. ChemBioChem: a European journal of chemical biology, 14(5), 559-563. [More Information]
  • Corcilius, L., Payne, R. (2013). Stereoselective synthesis of sialylated tumor-associated glycosylamino acids. Organic Letters, 15(22), 5794-5797. [More Information]
  • Ziarek, J., Getschman, A., Butler, S., Taleski, D., Stephens, B., Kufareva, I., Handel, T., Payne, R., Volkman, B. (2013). Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chemical Biology, 8(9), 1955-1963. [More Information]
  • Al Sheikha, D., Wilkinson, B., Santhakumar, G., Thaysen-Andersen, M., Payne, R. (2013). Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy. Organic and Biomolecular Chemistry, 11(36), 6090-6096. [More Information]
  • Corcilius, L., Santhakumar, G., Stone, R., Capicciotti, C., Joseph, S., Matthews, J., Ben, R., Payne, R. (2013). Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules. Bioorganic and Medicinal Chemistry, 21(12), 3569-3581. [More Information]
  • Payne, R. (2013). Total Synthesis of Erythropoietin through the Development and Exploitation of Enabling Synthetic Technologies. Angewandte Chemie (International Edition), 52(2), 505-507. [More Information]
  • Giltrap, A., Cergol, K., Pang, A., Britton, W., Payne, R. (2013). Total Synthesis of Fellutamide B and Deoxy-Fellutamides B, C, and D. Marine Drugs, 11(7), 2382-2397. [More Information]
  • Tan, J., Ludeman, J., Wedderburn, J., Canals, M., Hall, P., Butler, S., Taleski, D., Christopoulos, A., Hickey, M., Payne, R., et al (2013). Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1). Journal of Biological Chemistry, 288(14), 10024-10034. [More Information]

2012

  • Tan, J., Canals, M., Ludeman, J., Wedderburn, J., Boston, C., Butler, S., Carrick, A., Parody, T., Taleski, D., Christopoulos, A., Payne, R., et al (2012). Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1). Journal of Biological Chemistry, 287(18), 14692-14702. [More Information]
  • Hsieh, Y., Taleski, D., Wilkinson, B., Wijeyewickrema, L., Adams, T., Pike, R., Payne, R. (2012). Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin. Chemical Communications, 48(10), 1547-1549. [More Information]
  • Tran, A., West, N., Britton, W., Payne, R. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. ChemMedChem: chemistry enabling drug discovery, 7(6), 1031-1043. [More Information]
  • Duncan, R., Mohlin, F., Taleski, D., Coetzer, T., Huntington, J., Payne, R., Blom, A., Pike, R., Wijeyewickrema, L. (2012). Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. Journal of Immunology, 189(5), 2365-2373. [More Information]
  • Bakmiwewa, S., Fatokun, A., Tran, A., Payne, R., Hunt, N., Ball, H. (2012). Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorganic & Medicinal Chemistry Letters, 22(24), 7641-7646. [More Information]
  • Chi, G., Manos-Turvey, A., O'Connor, P., Johnston, J., Evans, G., Baker, E., Payne, R., Lott, J., Bulloch, E. (2012). Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry, 51(24), 4868-4879. [More Information]
  • Maghzal, G., Cergol, K., Suarna, C., Newington, D., Kettle, A., Payne, R., Stocker, R. (2012). In vivo detection of myeloperoxidase activity by LC/MS analysis of 2-chloro-ethidium, a novel product formed from the reaction of hydroethidine with hypochlorous acid and chloramines. Free Radical Biology and Medicine, 53(supplement 1), s223-s224. [More Information]
  • Andrews, D., Heazlewood, B., Maccarone, A., Conroy, T., Payne, R., Jordan, M., Kable, S. (2012). Photo-tautomerization of acetaldehyde to vinyl alcohol: A potential route to tropospheric acids. Science, 337(6099), 1203-1206. [More Information]
  • Manos-Turvey, A., Cergol, K., Salam, N., Bulloch, E., Chi, G., Pang, A., Britton, W., West, N., Baker, E., Lott, J., Payne, R. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10(46), 9223-9236. [More Information]
  • Wilkinson, B., Day, S., Chapman, R., Perrier, S., Apostolopoulos, V., Payne, R. (2012). Synthesis and immunological evaluation of self-assembling and self-adjuvanting tricomponent glycopeptide cancer-vaccine candidates. Chemistry: A European Journal, 18(51), 16540-16548. [More Information]
  • Graham, M., Stone, R., Robinson, P., Payne, R. (2012). Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked beta-N-acetylglucosaminyl-6-phosphate modification. Organic and Biomolecular Chemistry, 10(13), 2545-2551. [More Information]
  • Malins, L., Payne, R. (2012). Synthesis and utility of beta-selenol-phenylalanine for native chemical ligation - deselenization chemistry. Organic Letters, 14(12), 3142-3145. [More Information]
  • Hsieh, Y., Wilkinson, B., O'Connell, M., Mackay, J., Matthews, J., Payne, R. (2012). Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Organic Letters, 14(7), 1910-1913. [More Information]
  • Thompson, R., Payne, R., Jolliffe, K. (2012). Total Synthesis of Cyclocitropside A and Its Conversion to Cyclocitropsides B and C via Asparagine Deamidation. Organic Letters, 14(19), 5110-5113. [More Information]
  • Wilkinson, B., Stone, R., Capicciotti, C., Thaysen-Andersen, M., Matthews, J., Packer, N., Ben, R., Payne, R. (2012). Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins. Angewandte Chemie (International Edition), 51(15), 3606-3610. [More Information]

2011

  • Taleski, D., Butler, S., Stone, M., Payne, R. (2011). Divergent and Site-Selective Solid-Phase Synthesis of Sulfopeptides. Chemistry - An Asian Journal, 6(6), 1316-1320. [More Information]
  • West, N., Cergol, K., Xue, M., Randall, E., Britton, W., Payne, R. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47(18), 5166-5168. [More Information]
  • Thomas, G., Hsieh, Y., Chun, C., Cai, Z., Reimers, J., Payne, R. (2011). Peptide ligations accelerated by N-terminal aspartate and glutamate residues. Organic Letters, 13(18), 4770-4773. [More Information]
  • Wilkinson, B., Day, S., Malins, L., Apostolopoulos, V., Payne, R. (2011). Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam(3)CysSer. Angewandte Chemie (International Edition), 50(7), 1635-1639. [More Information]
  • Kakwere, H., Payne, R., Jolliffe, K., Perrier, S. (2011). Self-assembling macromolecular chimeras: Controlling fibrillization of a β-sheet forming peptide by polymer conjugation. Soft Matter, 7(8), 3754-3757. [More Information]
  • Thaysen-Andersen, M., Wilkinson, B., Payne, R., Packer, N. (2011). Site-specific characterisation of densely O-glycosylated mucin-type peptides using electron transfer dissociation ESI-MS/MS. Electrophoresis, 32(24), 3536-3545. [More Information]
  • Dias, M., Snee, W., Bromfield, K., Payne, R., Palaninathan, S., Ciulli, A., Howard, N., Abell, C., Sacchettini, J., Blundell, T. (2011). Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochemical Journal, 436(3), 729-739. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and Evaluation of Potent Ene-yne inhibitors of type II Dehydroquinases as Tuberculosis Drug Leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Tran, A., Cergol, K., West, N., Randall, E., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2011). Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem: chemistry enabling drug discovery, 6(2), 262-265. [More Information]
  • Wilkinson, B., Chun, C., Payne, R. (2011). Synthesis of MUC1 Glycopeptide Thioesters and Ligation Via Direct Aminolysis. Biopolymers : Peptide Science, 96(2), 137-146. [More Information]
  • Chim, N., Habel, J., Johnston, J., Krieger, I., Miallau, L., Sankaranarayanan, R., Morse, R., Bruning, J., Swanson, S., Kim, H., Payne, R., Manos-Turvey, A., et al (2011). The TB Structural Genomics Consortium: A decade of progress. Tuberculosis, 91(2), 155-172. [More Information]
  • Thompson, R., Jolliffe, K., Payne, R. (2011). Total Synthesis of Microcin B17 via a Fragment Condensation Approach. Organic Letters, 13(4), 680-683. [More Information]
  • Conroy, T., Guo, J., Linington, R., Hunt, N., Payne, R. (2011). Total synthesis, Stereochemical Assignment, and Antimalarial Activity of Gallinamide A. Chemistry: A European Journal, 17(48), 13544-13552. [More Information]
  • Zhu, J., Millard, C., Ludeman, J., Simpson, L., Clayton, D., Payne, R., Widlanski, T., Stone, M. (2011). Tyrosine Sulfation Influences the Chemokine Binding Selectivity of Peptides Derived from Chemokine Receptor CCR3. Biochemistry, 50(9), 1524-1534. [More Information]

2010

  • Payne, R., Wong, C. (2010). Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins. Chemical Communications, 46(1), 21-43. [More Information]
  • Holt, D., Payne, R., Chow, W., Abell, C. (2010). Fluorosurfactants for microdroplets: Interfacial tension analysis. Journal of Colloid and Interface Science, 350(1), 205-211. [More Information]
  • Payne, R., Bulloch, E., Kerbarh, O., Abell, C. (2010). Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues. Organic and Biomolecular Chemistry, 8(15), 3534-3542.
  • Manos-Turvey, A., Bulloch, E., Rutledge, P., Baker, E., Lott, J., Payne, R. (2010). Inhibition studies of mycobacterium tuberculosis salicylate synthase (Mbtl). ChemMedChem: chemistry enabling drug discovery, 5(7), 1067-1079. [More Information]
  • Kakwere, H., Chun, C., Jolliffe, K., Payne, R., Perrier, S. (2010). Polymer-peptide chimeras for the multivalent display of immunogenic peptides. Chemical Communications, 46(13), 2188-2190. [More Information]
  • Tran, A., Cergol, K., Britton, W., Bokhari, S., Ibrahim, M., Lapthorn, A., Payne, R. (2010). Rapid assembly of potent type II dehydroquinase inhibitors via "click" chemistry. MedChemComm (Medicinal Chemistry Communications), 1(4), 271-275.
  • Wilkinson, B., Malins, L., Chun, C., Payne, R. (2010). Synthesis of MUC1-lipopeptide chimeras. Chemical Communications, 46(34), 6249-6251.
  • Conroy, T., Jolliffe, K., Payne, R. (2010). Synthesis of N-linked glycopeptides via solid-phase aspartylation. Organic and Biomolecular Chemistry, 8(16), 3723-3733.
  • Holt, D., Payne, R., Abell, C. (2010). Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams. Journal of Fluorine Chemistry, 131(3), 398-407. [More Information]
  • Conroy, T., Guo, J., Hunt, N., Payne, R. (2010). Total synthesis and antimalarial activity of symplostatin 4. Organic Letters, 12(23), 5576-5579. [More Information]

2009

  • Conroy, T., Jolliffe, K., Payne, R. (2009). Efficient use of the Dmab protecting group: Applications for the solid-phase synthesis of N-linked glycopeptides. Organic and Biomolecular Chemistry, 7(11), 2255-2258.
  • Payne, R. (2009). Inhibition of Shikimate pathway enzymes as novel antibacterial leads (Biota Medal Lecture). 7th AFMC International Medicinal Chemistry Symposium, N/A: N/A.
  • Payne, R. (2009). Ligation-based assembly of glycopeptides and glycoproteins. Seminar, School of Chemistry, Monash University, N/A: N/A.
  • Payne, R. (2009). New ligation strategies for the synthesis of peptides bearing post-translational modifications (Invited lecture). 8th Australian Peptide Conference.
  • Payne, R. (2009). New strategies for the synthesis of glycopeptides and glycoproteins. Seminar, School of Chemistry, University of New South Wales, N/A: N/A.
  • Payne, R. (2009). New strategies for the synthesis of post-translationally modified peptides and proteins. Seminar, School of Chemistry and Physics, University of Adelaide, N/A: N/A.
  • Payne, R. (2009). New strategies for the synthesis of post-translationally modified peptides and proteins. Chemistry Seminar program 2009 - School of Chemistry @ UOW, N/A: N/A.
  • Thomas, G., Payne, R. (2009). Phosphate-assisted peptide ligation. Chemical Communications, 2009 (28), 4260-4262.
  • Payne, R., Bulloch, E., Toscano, M., Jones, M., Kerbarh, O., Abell, C. (2009). Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. Organic and Biomolecular Chemistry, 7(11), 2421-2429.
  • Garner, J., Jolliffe, K., Harding, M., Payne, R. (2009). Synthesis of homogeneous antifreeze glycopeptides via a ligation-desulfurisation strategy. Chemical Communications, 45(45), 6925-6927.
  • Chun, C., Payne, R. (2009). Synthesis of MUC1 peptide and glycopeptide dendrimers. Australian Journal of Chemistry: an international journal for chemical science, 62(10), 1339-1343.
  • Payne, R. (2009). Synthesis of N-linked glycopeptides via solid-phase aspartylation (Invited lecture). Modern Solid Phase Peptide Synthesis and its Applications.
  • Thordarson, P., Payne, R. (2009). The inaugural Australian workshop on bioconjugate chemistry, UNSW 2008. Australian Journal of Chemistry: an international journal for chemical science, 62(10), 1318-1319.

2008

  • Bennett, C., Payne, R., Koeller, K., Wong, C. (2008). Biologically relevant glycopeptides: Synthesis and applications. In Bertram O Fraser-Reid, Kuniaki Tatsuta, Joachim Thiem (Eds.), Glycoscience. Chemistry and Chemical Biology, (pp. 1795-1857). New York, USA: Springer.
  • Payne, R., Ficht, S., Greenberg, W., Wong, C. (2008). Cysteine-free peptide and glycopeptide ligation by direct aminolysis. Angewandte Chemie (International Edition), 47(23), 4411-4415. [More Information]
  • Ficht, S., Payne, R., Guy, R., Wong, C. (2008). Solid-phase synthesis of peptide and glycopeptide thioesters through side-chain-anchoring strategies. Chemistry: A European Journal, 14(12), 3620-3629. [More Information]
  • Bennett, C., Dean, S., Payne, R., Ficht, S., Brik, A., Wong, C. (2008). Sugar-assisted glycopeptide ligation with complex oligosaccharides: Scope and limitations. Journal of the American Chemical Society, 130(36), 11945-11952.

2007

  • Payne, R., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A., Lapthorn, A., Abell, C. (2007). Design, Synthesis, and Structural Studies on Potent Biaryl Inhibitors of Type II Dehydroquinases. ChemMedChem: chemistry enabling drug discovery, 2(7), 1010-1013. [More Information]
  • Payne, R., Ficht, S., Tang, S., Brik, A., Yang, Y., Case, D., Wong, C. (2007). Extended Sugar-Assisted Glycopeptide Ligations: Development, Scope, and Applications. Journal of the American Chemical Society, 129(44), 13527-13536.
  • Abell, A., Jones, M., Neffe, A., Aitken, S., Cain, T., Payne, R., McNabb, S., Coxon, J., Stuart, B., Pearson, D., et al (2007). Investigation into the P3 Binding Domain of m-Calpain Using Photoswitchable Diazo- and Triazene-dipeptide Aldehydes: New Anticataract Agents. Journal of Medicinal Chemistry, 50(12), 2916-2920.
  • Toscano, M., Payne, R., Chiba, A., Kerbarh, O., Abell, C. (2007). Nanomolar Inhibition of Type II Dehydroquinase Based on the Enolate Reaction Mechanism. ChemMedChem: chemistry enabling drug discovery, 2(1), 101-112. [More Information]
  • Payne, R., Peyrot, F., Kerbarh, O., Abell, A., Abell, C. (2007). Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors. ChemMedChem: chemistry enabling drug discovery, 2(7), 1015-1029. [More Information]
  • Ficht, S., Payne, R., Brik, A., Wong, C. (2007). Second-Generation Sugar-Assisted Ligation: A Method for the Synthesis of Cysteine-Containing Glycopeptides. Angewandte Chemie (International Edition), 46(31), 5975-5979. [More Information]

2005

  • Payne, R., Bulloch, E., Abell, A., Abell, C. (2005). Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic and Biomolecular Chemistry, 3(20), 3629-3635.
  • Payne, R., Kerbarh, O., Miguel, R., Abell, A., Abell, C. (2005). Inhibition studies on salicylate synthase. Organic and Biomolecular Chemistry, 3(10), 1825-1827.
  • Payne, R., Edmonds, M. (2005). Isolation of Shikimic Acid from Star Aniseed. Journal of Chemical Education, 82(4), 599-600.
  • Kerbarh, O., Bulloch, E., Payne, R., Sahr, T., Rebeille, F., Abell, C. (2005). Mechanistic and inhibition studies of chorismate-utilizing enzymes. Biochemical Society Transactions, 33(4), 763-766.

2004

  • Payne, R., Brown, K., Coxon, J., Morton, J., Lee, H., Abell, A. (2004). Peptidic aldehydes based on alpha- and beta-amino acids: Synthesis, inhibition of m-calpain, and anti-cataract properties. Australian Journal of Chemistry: an international journal for chemical science, 57(9), 877-884.
  • Payne, R., Daines, A., Clark, B., Abell, A. (2004). Synthesis and protein conjugation studies of vitamin K analogues. Bioorganic and Medicinal Chemistry, 12(22), 5785-5791. [More Information]

2003

  • de Zwart, F., Slow, S., Payne, R., Lever, M., George, P., Gerrard, J., Chambers, S. (2003). Glycine betaine and glycine betaine analogues in common foods. Food Chemistry, 83(2), 197-204.
  • Daines, A., Payne, R., Humphries, M., Abell, A. (2003). The Synthesis of Naturally Occurring Vitamin K and Vitamin K Analogues. Current Organic Chemistry, 7(16), 1625-1634.

2002

  • Payne, R., Abell, A. (2002). Protein binding studies of vitamin K analogues for use in an immunological assay. Chemistry in New Zealand, 66(1), 16-26.

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