Dr Rita Machaalani

Clinical Senior Lecturer
Medicine, Central Clinical School
Bosch Institute

Telephone +61 2 9351 3851
Fax +61 2 9550 3851

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Research interests

Neuropathological changes in the Sudden Infant death Syndrome (SIDS) with specific focus on apoptosis and NMDA

Selected grants

2012

  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Journals

  • Machaalani, R., Ghazavi, E., Hinton, T., Waters, K., Hennessy, A. (2014). Cigarette smoking during pregnancy regulates the expression of specific nicotinic acetylcholine receptor (nAChR) subunits in the human placenta. Toxicology and Applied Pharmacology, 276(3), 204-212. [More Information]
  • Machaalani, R., Hunt, N., Waters, K. (2013). Effects of changes in energy homeostasis and exposure of noxious insults on the expression of orexin (hypocretin) and its receptors in the brain. Brain Research, 1526, 102-122. [More Information]
  • Hunt, N., Waters, K., Machaalani, R. (2013). Orexin receptors in the developing piglet hypothalamus, and effects of nicotine and intermittent hypercapnic hypoxia exposures. Brain Research, 1508, 73-82. [More Information]
  • Bejjani, C., Machaalani, R., Waters, K. (2013). The dorsal motor nucleus of the vagus (DMNV) in sudden infant death syndrome (SIDS): Pathways leading to apoptosis. Respiratory Physiology and Neurobiology, 185(2), 203-210. [More Information]
  • Tang, S., Machaalani, R., Waters, K. (2012). Expression of brain-derived neurotrophic factor and TrkB receptor in the sudden infant death syndrome brainstem. Respiratory Physiology and Neurobiology, 180(1), 25-33. [More Information]
  • Machaalani, R., Say, M., Waters, K. (2011). Effects of cigarette smoke exposure on nicotinic acetylcholine receptor subunits α7 and β2 in the sudden infant death syndrome (SIDS) brainstem. Toxicology and Applied Pharmacology, 257(3), 396-404. [More Information]
  • Hensley, R., Machaalani, R., Cheng, A., Waters, K. (2011). How effective is adenoidectomy alone for treatment of obstructive sleep apnoea in a child who presents with adenoid hypertrophy? Journal of Paediatrics and Child Health, 47, 568-571. [More Information]
  • Machaalani, R., Katebi Kashi, P., Waters, K. (2010). Distribution of nicotinic acetylcholine receptor subunits alpha7 and beta2 in the human brainstem and hippocampal formation. Journal of Chemical Neuroanatomy, 40(3), 223-231. [More Information]
  • Machaalani, R., Gozal, E., Berger, F., Waters, K., Dematteis, M. (2010). Effects of post-mortem intervals on regional brain protein profiles in rats using SELDI-TOF-MS analysis. Neurochemistry International, 57(6), 655-661. [More Information]
  • Tang, S., Machaalani, R., Waters, K. (2010). Immunolocalisation of pro- and mature-brain derived neurotrophic factor (BDNF) and receptor TrkB in the human brainstem and hippocampus. Brain Research, 1354 (doi:10.1016/j.brainres.2010.07.051), 1-14. [More Information]
  • Browne, C., Sharma, N., Waters, K., Machaalani, R. (2010). The effects of nicotine on the alpha-7 and beta-2 nicotinic acetycholine receptor subunits in the developing piglet brainstem. International Journal of Developmental Neuroscience, 28, 1-7. [More Information]
  • Kashem, M., Sarker, R., Des Etages, H., Machaalani, R., King, N., McGregor, I., Matsumoto, I. (2009). Comparative proteomics in the corpus callosal sub-regions of postmortem human brain. Neurochemistry International, 55(7), 483-490. [More Information]
  • Tang, S., Machaalani, R., Kashem, M., Matsumoto, I., Waters, K. (2009). Intermittent Hypercapnic Hypoxia Induced Protein Changes in the Piglet Hippocampus Identified by MALDI-TOF-MS. Neurochemical Research, 34(12), 2215-2225. [More Information]
  • Machaalani, R., Say, M., Waters, K. (2009). Serotoninergic receptor 1A in the sudden infant death syndrome brainstem medulla and associations with clinical risk factors. Acta Neuropathologica, 117(3), 257-265. [More Information]
  • Tang, S., Machaalani, R., Waters, K. (2008). Brain-derived neurotrophic factor (BDNF) and TrkB in the piglet brainstem after post-natal nicotine and intermittent hypercapnic hypoxia. Brain Research, 1232, 195-205. [More Information]
  • Machaalani, R., Waters, K. (2008). Neuronal cell death in the Sudden Infant Death Syndrome brainstem and associations with risk factors. Brain, 131(Pt 1), 218-228. [More Information]
  • Machaalani, R., Makris, A., Thornton, C., Hennessy, A. (2008). Vascular Endothelial Growth Factor Receptor 1 (Flt1) and Apoptosis in the Preeclamptic Placenta and Effects of in vivo Anti-hypertensive Exposure. Hypertension in Pregnancy, 27(4), 361-373. [More Information]
  • Machaalani, R., Arlotto, M., Waters, K., Gozal, E., Berger, F., Dematteis, M. (2007). A Novel Method of Tissue Collection and Storage: Validation Using SELDI-TOF MS Analysis. Clinical Chemistry (Washington, DC). [More Information]
  • Machaalani, R., Rodriguez, M., Waters, K. (2007). Active caspase-3 in the sudden infant death syndrome (SIDS) brainstem. Acta Neuropathologica. [More Information]
  • Say, M., Machaalani, R., Waters, K. (2007). Changes in serotoninergic receptors 1A and 2A in the piglet brainstem after intermittent hypercapnic hypoxia (IHH) and nicotine. Brain Research, 1152, 17-26. [More Information]
  • Machaalani, R., Radford, J., Waters, K. (2007). Tissue fixation effects on immunohistochemical staining of caspase-3 in brain tissue. Applied Immunohistochemistry and Molecular Morphology, 15(4), 463-470. [More Information]
  • Fanous, A., Machaalani, R., Waters, K. (2006). N-methyl-d-aspartate receptor 1 changes in the piglet brainstem after nicotine and/or intermittent hypercapnic-hypoxia. Neuroscience, 142(2), 401-409. [More Information]
  • Machaalani, R., Waters, K. (2006). Postnatal nicotine and/or intermittent hypercapnic hypoxia effects on apoptotic markers in the developing piglet brainstem medulla. Neuroscience, 142(1), 107-117. [More Information]
  • Machaalani, R., Waters, K., Tinworth, K. (2005). Effects of postnatal nicotine exposure on apoptotic markers in the developing piglet brain. Neuroscience, 132(2), 325-333. [More Information]
  • Waters, K., Machaalani, R. (2005). Role of NMDA receptors in development of respiratory control. Respiratory Physiology and Neurobiology, 149(1-3). [More Information]
  • Peiris, T., Machaalani, R., Waters, K. (2004). Brain-Derived Neurotrophic Factor Mrna And Protein In The Piglet Brainstem And Effects Of Intermittent Hypercapnic Hypoxia. Brain Research, 1029 (1), 11-23. [More Information]
  • Waters, K., Machaalani, R. (2004). Nmda Receptors In The Developing Brain And Effects Of Noxious Insults. NeuroSignals, 13(4), 162-174.
  • Machaalani, R., Waters, K. (2003). Correlations between brainstem NMDA receptor changes and active neuronal cell death after intermittent hypercapnic hypoxia in the developing piglet. Brain Research, 975(1-2), 141-148.
  • Machaalani, R., Waters, K. (2003). Increased neuronal cell death after intermittent hypercapnic hypoxia in the developing piglet brainstem. Brain Research, 985(2), 127-134.
  • Machaalani, R., Waters, K. (2003). NMDA receptor 1 expression in the brainstem of human infants and its relevance to the sudden infant death syndrome (SIDS). Journal of Neuropathology and Experimental Neurology, 62(10), 1076-1085.
  • Machaalani, R., Waters, K. (2002). Distribution and quantification of NMDA R1 and mRNA and protein in the piglet brainstem and effects of intermittent hypercapnic hopoxia (IHH). Brain Research, 951(2), 293-300.
  • Relf, B., Machaalani, R., Waters, K. (2002). Retrieval of mRNA from paraffin-embedded human infant brain tissue for non-radioactive in situ hybridization using oligonucleotides. Journal of Neuroscience Methods, 115(2), 129-136.

2014

  • Machaalani, R., Ghazavi, E., Hinton, T., Waters, K., Hennessy, A. (2014). Cigarette smoking during pregnancy regulates the expression of specific nicotinic acetylcholine receptor (nAChR) subunits in the human placenta. Toxicology and Applied Pharmacology, 276(3), 204-212. [More Information]

2013

  • Machaalani, R., Hunt, N., Waters, K. (2013). Effects of changes in energy homeostasis and exposure of noxious insults on the expression of orexin (hypocretin) and its receptors in the brain. Brain Research, 1526, 102-122. [More Information]
  • Hunt, N., Waters, K., Machaalani, R. (2013). Orexin receptors in the developing piglet hypothalamus, and effects of nicotine and intermittent hypercapnic hypoxia exposures. Brain Research, 1508, 73-82. [More Information]
  • Bejjani, C., Machaalani, R., Waters, K. (2013). The dorsal motor nucleus of the vagus (DMNV) in sudden infant death syndrome (SIDS): Pathways leading to apoptosis. Respiratory Physiology and Neurobiology, 185(2), 203-210. [More Information]

2012

  • Tang, S., Machaalani, R., Waters, K. (2012). Expression of brain-derived neurotrophic factor and TrkB receptor in the sudden infant death syndrome brainstem. Respiratory Physiology and Neurobiology, 180(1), 25-33. [More Information]

2011

  • Machaalani, R., Say, M., Waters, K. (2011). Effects of cigarette smoke exposure on nicotinic acetylcholine receptor subunits α7 and β2 in the sudden infant death syndrome (SIDS) brainstem. Toxicology and Applied Pharmacology, 257(3), 396-404. [More Information]
  • Hensley, R., Machaalani, R., Cheng, A., Waters, K. (2011). How effective is adenoidectomy alone for treatment of obstructive sleep apnoea in a child who presents with adenoid hypertrophy? Journal of Paediatrics and Child Health, 47, 568-571. [More Information]

2010

  • Machaalani, R., Katebi Kashi, P., Waters, K. (2010). Distribution of nicotinic acetylcholine receptor subunits alpha7 and beta2 in the human brainstem and hippocampal formation. Journal of Chemical Neuroanatomy, 40(3), 223-231. [More Information]
  • Machaalani, R., Gozal, E., Berger, F., Waters, K., Dematteis, M. (2010). Effects of post-mortem intervals on regional brain protein profiles in rats using SELDI-TOF-MS analysis. Neurochemistry International, 57(6), 655-661. [More Information]
  • Tang, S., Machaalani, R., Waters, K. (2010). Immunolocalisation of pro- and mature-brain derived neurotrophic factor (BDNF) and receptor TrkB in the human brainstem and hippocampus. Brain Research, 1354 (doi:10.1016/j.brainres.2010.07.051), 1-14. [More Information]
  • Browne, C., Sharma, N., Waters, K., Machaalani, R. (2010). The effects of nicotine on the alpha-7 and beta-2 nicotinic acetycholine receptor subunits in the developing piglet brainstem. International Journal of Developmental Neuroscience, 28, 1-7. [More Information]

2009

  • Kashem, M., Sarker, R., Des Etages, H., Machaalani, R., King, N., McGregor, I., Matsumoto, I. (2009). Comparative proteomics in the corpus callosal sub-regions of postmortem human brain. Neurochemistry International, 55(7), 483-490. [More Information]
  • Tang, S., Machaalani, R., Kashem, M., Matsumoto, I., Waters, K. (2009). Intermittent Hypercapnic Hypoxia Induced Protein Changes in the Piglet Hippocampus Identified by MALDI-TOF-MS. Neurochemical Research, 34(12), 2215-2225. [More Information]
  • Machaalani, R., Say, M., Waters, K. (2009). Serotoninergic receptor 1A in the sudden infant death syndrome brainstem medulla and associations with clinical risk factors. Acta Neuropathologica, 117(3), 257-265. [More Information]

2008

  • Tang, S., Machaalani, R., Waters, K. (2008). Brain-derived neurotrophic factor (BDNF) and TrkB in the piglet brainstem after post-natal nicotine and intermittent hypercapnic hypoxia. Brain Research, 1232, 195-205. [More Information]
  • Machaalani, R., Waters, K. (2008). Neuronal cell death in the Sudden Infant Death Syndrome brainstem and associations with risk factors. Brain, 131(Pt 1), 218-228. [More Information]
  • Machaalani, R., Makris, A., Thornton, C., Hennessy, A. (2008). Vascular Endothelial Growth Factor Receptor 1 (Flt1) and Apoptosis in the Preeclamptic Placenta and Effects of in vivo Anti-hypertensive Exposure. Hypertension in Pregnancy, 27(4), 361-373. [More Information]

2007

  • Machaalani, R., Arlotto, M., Waters, K., Gozal, E., Berger, F., Dematteis, M. (2007). A Novel Method of Tissue Collection and Storage: Validation Using SELDI-TOF MS Analysis. Clinical Chemistry (Washington, DC). [More Information]
  • Machaalani, R., Rodriguez, M., Waters, K. (2007). Active caspase-3 in the sudden infant death syndrome (SIDS) brainstem. Acta Neuropathologica. [More Information]
  • Say, M., Machaalani, R., Waters, K. (2007). Changes in serotoninergic receptors 1A and 2A in the piglet brainstem after intermittent hypercapnic hypoxia (IHH) and nicotine. Brain Research, 1152, 17-26. [More Information]
  • Machaalani, R., Radford, J., Waters, K. (2007). Tissue fixation effects on immunohistochemical staining of caspase-3 in brain tissue. Applied Immunohistochemistry and Molecular Morphology, 15(4), 463-470. [More Information]

2006

  • Fanous, A., Machaalani, R., Waters, K. (2006). N-methyl-d-aspartate receptor 1 changes in the piglet brainstem after nicotine and/or intermittent hypercapnic-hypoxia. Neuroscience, 142(2), 401-409. [More Information]
  • Machaalani, R., Waters, K. (2006). Postnatal nicotine and/or intermittent hypercapnic hypoxia effects on apoptotic markers in the developing piglet brainstem medulla. Neuroscience, 142(1), 107-117. [More Information]

2005

  • Machaalani, R., Waters, K., Tinworth, K. (2005). Effects of postnatal nicotine exposure on apoptotic markers in the developing piglet brain. Neuroscience, 132(2), 325-333. [More Information]
  • Waters, K., Machaalani, R. (2005). Role of NMDA receptors in development of respiratory control. Respiratory Physiology and Neurobiology, 149(1-3). [More Information]

2004

  • Peiris, T., Machaalani, R., Waters, K. (2004). Brain-Derived Neurotrophic Factor Mrna And Protein In The Piglet Brainstem And Effects Of Intermittent Hypercapnic Hypoxia. Brain Research, 1029 (1), 11-23. [More Information]
  • Waters, K., Machaalani, R. (2004). Nmda Receptors In The Developing Brain And Effects Of Noxious Insults. NeuroSignals, 13(4), 162-174.

2003

  • Machaalani, R., Waters, K. (2003). Correlations between brainstem NMDA receptor changes and active neuronal cell death after intermittent hypercapnic hypoxia in the developing piglet. Brain Research, 975(1-2), 141-148.
  • Machaalani, R., Waters, K. (2003). Increased neuronal cell death after intermittent hypercapnic hypoxia in the developing piglet brainstem. Brain Research, 985(2), 127-134.
  • Machaalani, R., Waters, K. (2003). NMDA receptor 1 expression in the brainstem of human infants and its relevance to the sudden infant death syndrome (SIDS). Journal of Neuropathology and Experimental Neurology, 62(10), 1076-1085.

2002

  • Machaalani, R., Waters, K. (2002). Distribution and quantification of NMDA R1 and mRNA and protein in the piglet brainstem and effects of intermittent hypercapnic hopoxia (IHH). Brain Research, 951(2), 293-300.
  • Relf, B., Machaalani, R., Waters, K. (2002). Retrieval of mRNA from paraffin-embedded human infant brain tissue for non-radioactive in situ hybridization using oligonucleotides. Journal of Neuroscience Methods, 115(2), 129-136.

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