Associate Professor Robert Heard

Clinical Associate Professor
Medicine, Westmead Clinical School

Telephone +61 2 4325 4488
Fax +61 2 4325 5310

Map

Selected grants

2011

  • Genetic Control of T cell Regulation in MS; Booth D, Stewart G, Vucic S, Heard R; Multiple Sclerosis Research Australia/Investigator Project Grants.

2006

  • Molecular response to interferon beta treatment in multiple sclerosis; Arthur J, Stewart G, Heard R, Booth D, Sedger L, Booth D, Stewart G, Heard R; Australian Research Council (ARC)/Linkage Projects (LP).

2005

  • Genes associated with multiple sclerosis; Stewart G, Booth D, Heard R, Compston A; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Detection of susceptibility genes for multiple sclerosis; Stewart G, Bennetts B, Heard R, Compston, A; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Mechelli, R., Umeton, R., Policano, C., Annibali, V., Coarelli, G., Ricigliano, V., Vittori, D., Fornasiero, A., Buscarinu, M., Booth, D., et al (2013). A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis. PLoS One, 8(5), 1-9. [More Information]
  • Lee, S., Harold, D., Nyholt, D., Goddard, M., Zondervan, K., Williams, J., Montgomery, G., Wray, N., Visscher, P., Scott, R., Booth, D., Stewart, G., Heard, R., et al (2013). Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Human Molecular Genetics, 22(4), 832-841. [More Information]
  • Patsopoulos, N., Barcellos, L., Hintzen, R., Schaefer, C., van Duijn, C., Noble, J., Raj, T., Booth, D., Stewart, G., Heard, R., et al (2013). Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS One, 9(11), 1-10. [More Information]
  • Lin, R., Charlesworth, J., Stankovich, J., Perreau, V., Brown, M., Taylor, B., Baxter, A., Kermode, A., Bahlo, M., Booth, D., Stewart, G., Barnett, M., Heard, R., et al (2013). Identity-by-Descent Mapping to Detect Rare Variants Conferring Susceptibility to Multiple Sclerosis. PLoS One, 8(3), 1-8. [More Information]
  • Sawcer, S., Hallenthal, G., Pirinen, M., Spencer, C., Patsopoulos, N., Moutsianas, L., Dilthey, A., Su, Z., et al, Booth, D., Heard, R., Stewart, G. (2011). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature, 476(7359), 214-219. [More Information]
  • Field, J., Browning, S., Johnson, L., Danoy, P., Varney, M., Tait, B., Gandhi, K., Charlesworth, J., Heard, R., The Australia and New Zealand Multiple Sclerosis Genetics Consortium, (., Stewart, G., Booth, D., et al (2010). A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis. PLoS One, 5(10, Article number e13454), e13454 - 1-e13454 - 7. [More Information]
  • Riveros, C., Mellor, D., Gandhi, K., McKay, F., Cox, M., Berretta, R., Vaezpour, S., Inostroza-Ponta, M., Broadley, S., Heard, R., Vucic, S., Stewart, G., Booth, D., et al (2010). A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis. PLoS One, 5(12), e14176-1-e14176-28. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Gandhi, K., Heard, R., Stewart, G., Booth, D. (2010). Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. Journal of Immunology, 184(5), 2512-2517. [More Information]
  • Esposito, F., Patsopolous, N., Cepok, S., Kockum, J., Leppa, V., Booth, D., Heard, R., Stewart, G., Cox, M., Scott, R., et al (2010). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes and Immunity, 11(5), 397-405. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2010). Interleukin 7 Receptor Alpha Chain (IL-7Ralpha) Haplotypes Vary in Their Influence on Multiple Sclerosis Susceptibility and Response to Interferon Beta. Journal of Interferon and Cytokine Research, 30(5), 291-298. [More Information]
  • Booth, D., Heard, R., Stewart, G., Cox, M., Scott, R., Lechner-Scott, J., Goris, A., Dobosi, R., Dubois, B., Saarela, J., et al (2010). Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics, 42(6), 469-470. [More Information]
  • Gandhi, K., McKay, F., Diefenbach, E., Crossett, B., Schibeci, S., Heard, R., Stewart, G., Booth, D., Arthur, J. (2010). Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis. PLoS One, 5(5), e10484 - 1-e10484 - 9. [More Information]
  • Gandhi, K., McKay, F., Cox, M., Riveros, C., Armstrong, N., Heard, R., Vucic, S., Williams, D., Stankovich, J., Brown, M., Stewart, G., Booth, D., et al (2010). The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Human Molecular Genetics, 19(11), 2134-2143. [More Information]
  • Ban, M., Goris, A., Lorentzen, A., Baker, A., Mihalova, T., Ingram, G., Booth, D., Heard, R., Stewart, G., Bogaert, E., et al (2009). Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal of Human Genetics, 17, 1309-1313. [More Information]
  • Gandhi, K., McKay, F., Schibeci, S., Arthur, J., Heard, R., Stewart, G., Booth, D. (2008). BAFF is a Biological Response Marker to IFN-beta Treatment in Multiple Sclerosis. Journal of Interferon and Cytokine Research, 28(9), 529-540. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2008). CD127 immunophenotyping suggests altered CD4(+) T cell regulation in primary progressive multiple sclerosis. Journal of Autoimmunity, 31(1), 52-58. [More Information]
  • Arthur, A., Armati, P., Bye, C., The Southern MS Genetics Consortium, N., Heard, R., Stewart, G., Pollard, J., Booth, D. (2008). Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Medical Genetics, 9(17), 1-12. [More Information]
  • Burfoot, R., Jensen, C., Field, J., Stankovich, J., Varney, M., Johnson, L., Butzkueven, H., Booth, D., Bahlo, M., Tait, B., Heard, R., Stewart, G., et al (2008). SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. Tissue Antigens: immune response genetics, 71(1), 42-50. [More Information]
  • Maroulis, H., Halmagyi, G., Heard, R., Cook, R. (2008). Sylvian aqueduct syndrome with slit ventricles in shunted hydrocephalus due to adult aqueduct stenosis. Journal of Neurosurgery, 109(5), 939-943. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2007). Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes and Immunity, 9((accepted 6 September, 2007)), 1-6. [More Information]
  • Heard, R. (2007). The spectrum of multiple sclerosis. Current Allergy and Asthma Reports, 7(4), 280-284. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Rubio, J., Stewart, G. (2006). An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians. BMC Medical Genetics, 7, 64-64. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2006). An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians. Multiple Sclerosis: clinical and laboratory research, 12(6), 710-722. [More Information]
  • McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2006). Analysis of neutralizing antibodies to therapeutic interferon-beta in multiple sclerosis patients: a comparison of three methods in a large Australasian cohort. Journal of Immunological Methods, 310(1-2), 20-29. [More Information]
  • Sawcer, S., Ban, M., Maranian, M., Yeo, T., Compston, A., Kirby, A., Daly, M., De Jager, P., Walsh, E., Heard, R., Stewart, G., Booth, D., et al (2005). A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Burgner, D., Stewart, G. (2005). An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients. European Journal of Human Genetics, 13(7), 815-822. [More Information]
  • Booth, D., Arthur, A., Teutsch, S., Bye, C., Rubio, J., Armati, P., Pollard, J., Heard, R., Stewart, G. (2005). Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. Journal of Molecular Medicine. [More Information]
  • Teutsch, S., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2004). Association Of Common T Cell Activation Gene Polymorphisms With Multiple Sclerosis In Australian Patients. Journal of Neuroimmunology, 148(2), 218-30. [More Information]
  • Clemson, L., Cumming, R., Kendig, H., Swann, M., Heard, R., Taylor, K. (2004). The Effectiveness Of A Community-Based Program For Reducing The Incidence Of Falls In The Elderly: A Randomized Trial. Journal of the American Geriatrics Society, 52(9), 1487-1494.
  • Ban, M., Sawcer, S., Heard, R., Bennetts, B., Adams, S., Booth, D., Perich, V., Setakis, E., Compston, A., Stewart, G. (2003). A genome-wide screen for linkage disequilibrium in Australian HLA-DRB1*1501 positive multiple sclerosis patients. Journal of Neuroimmunology, 143(1-2), 60-64. [More Information]
  • Teutsch, S., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2003). Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis. European Journal of Human Genetics, 11(7), 509-515.
  • Ban, M., Stewart, G., Bennetts, B., Heard, R., Simmons, R., Maranian, M., Compston, A., Sawcer, S. (2002). A genome screen for linkage in Australian sibling-pairs with multiple sclerosis. Genes and Immunity, 3(8), 464-469.
  • Huang, Q., Teutsch, S., Buhler, M., Bennetts, B., Heard, R., Manolios, N., Stewart, G. (2000). Evaluation of the Apo-1/Fas promoter Mva 1 polymorphism in multiple sclerosis. Multiple Sclerosis: clinical and laboratory research, 6(1), 14-18.

2013

  • Mechelli, R., Umeton, R., Policano, C., Annibali, V., Coarelli, G., Ricigliano, V., Vittori, D., Fornasiero, A., Buscarinu, M., Booth, D., et al (2013). A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis. PLoS One, 8(5), 1-9. [More Information]
  • Lee, S., Harold, D., Nyholt, D., Goddard, M., Zondervan, K., Williams, J., Montgomery, G., Wray, N., Visscher, P., Scott, R., Booth, D., Stewart, G., Heard, R., et al (2013). Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Human Molecular Genetics, 22(4), 832-841. [More Information]
  • Patsopoulos, N., Barcellos, L., Hintzen, R., Schaefer, C., van Duijn, C., Noble, J., Raj, T., Booth, D., Stewart, G., Heard, R., et al (2013). Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS One, 9(11), 1-10. [More Information]
  • Lin, R., Charlesworth, J., Stankovich, J., Perreau, V., Brown, M., Taylor, B., Baxter, A., Kermode, A., Bahlo, M., Booth, D., Stewart, G., Barnett, M., Heard, R., et al (2013). Identity-by-Descent Mapping to Detect Rare Variants Conferring Susceptibility to Multiple Sclerosis. PLoS One, 8(3), 1-8. [More Information]

2011

  • Sawcer, S., Hallenthal, G., Pirinen, M., Spencer, C., Patsopoulos, N., Moutsianas, L., Dilthey, A., Su, Z., et al, Booth, D., Heard, R., Stewart, G. (2011). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature, 476(7359), 214-219. [More Information]

2010

  • Field, J., Browning, S., Johnson, L., Danoy, P., Varney, M., Tait, B., Gandhi, K., Charlesworth, J., Heard, R., The Australia and New Zealand Multiple Sclerosis Genetics Consortium, (., Stewart, G., Booth, D., et al (2010). A Polymorphism in the HLA-DPB1 Gene Is Associated with Susceptibility to Multiple Sclerosis. PLoS One, 5(10, Article number e13454), e13454 - 1-e13454 - 7. [More Information]
  • Riveros, C., Mellor, D., Gandhi, K., McKay, F., Cox, M., Berretta, R., Vaezpour, S., Inostroza-Ponta, M., Broadley, S., Heard, R., Vucic, S., Stewart, G., Booth, D., et al (2010). A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis. PLoS One, 5(12), e14176-1-e14176-28. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Gandhi, K., Heard, R., Stewart, G., Booth, D. (2010). Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. Journal of Immunology, 184(5), 2512-2517. [More Information]
  • Esposito, F., Patsopolous, N., Cepok, S., Kockum, J., Leppa, V., Booth, D., Heard, R., Stewart, G., Cox, M., Scott, R., et al (2010). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes and Immunity, 11(5), 397-405. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2010). Interleukin 7 Receptor Alpha Chain (IL-7Ralpha) Haplotypes Vary in Their Influence on Multiple Sclerosis Susceptibility and Response to Interferon Beta. Journal of Interferon and Cytokine Research, 30(5), 291-298. [More Information]
  • Booth, D., Heard, R., Stewart, G., Cox, M., Scott, R., Lechner-Scott, J., Goris, A., Dobosi, R., Dubois, B., Saarela, J., et al (2010). Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics, 42(6), 469-470. [More Information]
  • Gandhi, K., McKay, F., Diefenbach, E., Crossett, B., Schibeci, S., Heard, R., Stewart, G., Booth, D., Arthur, J. (2010). Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis. PLoS One, 5(5), e10484 - 1-e10484 - 9. [More Information]
  • Gandhi, K., McKay, F., Cox, M., Riveros, C., Armstrong, N., Heard, R., Vucic, S., Williams, D., Stankovich, J., Brown, M., Stewart, G., Booth, D., et al (2010). The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Human Molecular Genetics, 19(11), 2134-2143. [More Information]

2009

  • Ban, M., Goris, A., Lorentzen, A., Baker, A., Mihalova, T., Ingram, G., Booth, D., Heard, R., Stewart, G., Bogaert, E., et al (2009). Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal of Human Genetics, 17, 1309-1313. [More Information]

2008

  • Gandhi, K., McKay, F., Schibeci, S., Arthur, J., Heard, R., Stewart, G., Booth, D. (2008). BAFF is a Biological Response Marker to IFN-beta Treatment in Multiple Sclerosis. Journal of Interferon and Cytokine Research, 28(9), 529-540. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2008). CD127 immunophenotyping suggests altered CD4(+) T cell regulation in primary progressive multiple sclerosis. Journal of Autoimmunity, 31(1), 52-58. [More Information]
  • Arthur, A., Armati, P., Bye, C., The Southern MS Genetics Consortium, N., Heard, R., Stewart, G., Pollard, J., Booth, D. (2008). Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission. BMC Medical Genetics, 9(17), 1-12. [More Information]
  • Burfoot, R., Jensen, C., Field, J., Stankovich, J., Varney, M., Johnson, L., Butzkueven, H., Booth, D., Bahlo, M., Tait, B., Heard, R., Stewart, G., et al (2008). SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. Tissue Antigens: immune response genetics, 71(1), 42-50. [More Information]
  • Maroulis, H., Halmagyi, G., Heard, R., Cook, R. (2008). Sylvian aqueduct syndrome with slit ventricles in shunted hydrocephalus due to adult aqueduct stenosis. Journal of Neurosurgery, 109(5), 939-943. [More Information]

2007

  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2007). Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes and Immunity, 9((accepted 6 September, 2007)), 1-6. [More Information]
  • Heard, R. (2007). The spectrum of multiple sclerosis. Current Allergy and Asthma Reports, 7(4), 280-284. [More Information]

2006

  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Rubio, J., Stewart, G. (2006). An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians. BMC Medical Genetics, 7, 64-64. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2006). An investigation of polymorphisms in the 4q1 3.3-21.1 CXC chemokine gene cluster for association with multiple sclerosis in Australians. Multiple Sclerosis: clinical and laboratory research, 12(6), 710-722. [More Information]
  • McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2006). Analysis of neutralizing antibodies to therapeutic interferon-beta in multiple sclerosis patients: a comparison of three methods in a large Australasian cohort. Journal of Immunological Methods, 310(1-2), 20-29. [More Information]

2005

  • Sawcer, S., Ban, M., Maranian, M., Yeo, T., Compston, A., Kirby, A., Daly, M., De Jager, P., Walsh, E., Heard, R., Stewart, G., Booth, D., et al (2005). A high-density screen for linkage in multiple sclerosis. American Journal of Human Genetics. [More Information]
  • Bugeja, M., Booth, D., Bennetts, B., Heard, R., Burgner, D., Stewart, G. (2005). An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients. European Journal of Human Genetics, 13(7), 815-822. [More Information]
  • Booth, D., Arthur, A., Teutsch, S., Bye, C., Rubio, J., Armati, P., Pollard, J., Heard, R., Stewart, G. (2005). Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. Journal of Molecular Medicine. [More Information]

2004

  • Teutsch, S., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2004). Association Of Common T Cell Activation Gene Polymorphisms With Multiple Sclerosis In Australian Patients. Journal of Neuroimmunology, 148(2), 218-30. [More Information]
  • Clemson, L., Cumming, R., Kendig, H., Swann, M., Heard, R., Taylor, K. (2004). The Effectiveness Of A Community-Based Program For Reducing The Incidence Of Falls In The Elderly: A Randomized Trial. Journal of the American Geriatrics Society, 52(9), 1487-1494.

2003

  • Ban, M., Sawcer, S., Heard, R., Bennetts, B., Adams, S., Booth, D., Perich, V., Setakis, E., Compston, A., Stewart, G. (2003). A genome-wide screen for linkage disequilibrium in Australian HLA-DRB1*1501 positive multiple sclerosis patients. Journal of Neuroimmunology, 143(1-2), 60-64. [More Information]
  • Teutsch, S., Booth, D., Bennetts, B., Heard, R., Stewart, G. (2003). Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis. European Journal of Human Genetics, 11(7), 509-515.

2002

  • Ban, M., Stewart, G., Bennetts, B., Heard, R., Simmons, R., Maranian, M., Compston, A., Sawcer, S. (2002). A genome screen for linkage in Australian sibling-pairs with multiple sclerosis. Genes and Immunity, 3(8), 464-469.

2000

  • Huang, Q., Teutsch, S., Buhler, M., Bennetts, B., Heard, R., Manolios, N., Stewart, G. (2000). Evaluation of the Apo-1/Fas promoter Mva 1 polymorphism in multiple sclerosis. Multiple Sclerosis: clinical and laboratory research, 6(1), 14-18.

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