Professor Robert Vandenberg

Professor
Pharmacology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 6734
Fax +61 2 9351 3868

Map

Research interests

Professor Vandenberg?s research interests have focused on understanding how neurotransmitter transporters work. These proteins play key roles in regulating neurotransmission in the brain and are also the targets of a number of theraputic drugs and drugs of abuse. The laboratory uses a number of state-of-the-art molecular and biophysical techniques to address questions as to how these proteins bind neurotransmitters, how drugs interact with and modulate transporters and how these processes go wrong in disease states such Chronic Pain,Schizophrenia and Ischemia following a stroke.

PhD and master's project opportunities

Selected grants

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The structural basis for glutamate transporter function; Ryan R, Vandenberg R; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Lipid Modulation of Glycine Transporters; Vandenberg R, Ryan R; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • PyroMark Q96 ID system; Richardson D, Stone J, Black J, King N, Mason R, Hunt N, Kril J, Murray M, Scolyer R, Halliday G, Vandenberg R, McMinn P, Chadban S, Byrne M, Ryan R, Dong Q, Lee C, Bishop A, Haass N, Fraser S, Hambly B, Sharland A, Kalinowski D, Assinder S, Yu Y, Bao B, Ju Y, Lovejoy D, Buckland M, Lane D, Dos Remedios C, Kovacevic Z, Sutherland G, Zhang D, Morris B, Suryo Rahmanto A, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Mechanism of glutamate transport from experimental and simulation studies; Kuyucak S, Ryan R, Vandenberg R; Australian Research Council (ARC)/Discovery Projects (DP).

2009

  • Drug binding Sites on Glycine Transporters; Vandenberg R, Ryan R; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Molecular Dynamics of Glutamate Transport; Vandenberg R, Ryan R; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Molecular and cellular basis for the analgesic properties of N-arachidynyl amino acids; Vandenberg R, Connor M, Vaughan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Novel endocannabinoid targets for the treatment of pain; Vandenberg R; University of Sydney/Bridging Support.
  • Srfb; Vandenberg R; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.
  • Glutamate transporter EAAT2 splice variants and their role in alzheimers disease; Vandenberg R; University of Sydney/Research & Development.

2004

  • 2-electrode voltage clamp (2EVC) and assessories; Vandenberg R, Mitrovic A, Cook D, Collins M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Ion permeation of glutamate transporters; Vandenberg R; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Arachidonic acid modulation of glutamate transporters; Vandenberg R, Connor M; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Kodak Image Station 440CF; Black J, Hunt N, Vandenberg R, Johnson P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2000

  • Molecular pharmacology and physiology of glycine transport; Vandenberg R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Modulation of glutamate transporters in the brain; Vandenberg R, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Molecular biology and pharmacology of glutamate transporters in the brain; Vandenberg R, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Carland, J., Edington, A., Scopelliti, A., Ryan, R., Vandenberg, R. (2013). Directed Mutagenesis in Structure Activity Studies of Neurotransmitter Transporters. In David Figurski (Eds.), Genetic Manipulation of DNA and Protein - Examples from Current Research, (pp. 167-184). Rijeka: InTech Publishers.
  • McKinzie, A., Ryan, R., Vandenberg, R. (2010). Site-Directed Mutagenesis in the Study of Membrane Transporters. In Qing Yan (Eds.), Membrane Transporters in Drug Discovery and Development: Methods and Protocols - Methods in Molecular Biology Volume 637, (pp. 277-293). New York: Humana Press.
  • Ryan, R., Mitrovic, A., Vandenberg, R. (2003). Site-directed mutagenesis in the study of membrane transportes. In Qing Yan (Eds.), Membrane Transporters: Methods and Protocols (Methods in Molecular Biology Vol. 227), (pp. 97-108). New Jersey, USA: Humana Press.

Journals

  • Carland, J., Handford, C., Ryan, R., Vandenberg, R. (2014). Lipid Inhibitors of High Affinity Glycine Transporters: Identification of a novel class of analgesics. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry, 73, 211-216. [More Information]
  • Scopelliti, A., Heinzelmann, G., Kuyucak, S., Ryan, R., Vandenberg, R. (2014). Na+ interactions with the neutral amino acid transporter. The Journal of Biological Chemistry, 289(25), 17468-17479. [More Information]
  • Vandenberg, R., Ryan, R. (2013). Mechanisms of glutamate transport. Physiological Reviews, 93(4), 1621-1657. [More Information]
  • Scopelliti, A., Ryan, R., Vandenberg, R. (2013). Molecular Determinants for Functional Differences between Alanine-Serine-Cysteine Transporter 1 and Other Glutamate Transporter Family Members. The Journal of Biological Chemistry, 288(12), 8250-8257. [More Information]
  • Carland, J., Mansfield, R., Ryan, R., Vandenberg, R. (2013). Oleoyl-L-carnitine inhibits glycine transport by GlyT2. British Journal of Pharmacology, 168(4), 891-902. [More Information]
  • Bastug, T., Heinzelmann, G., Kuyucak, S., Salim, M., Vandenberg, R., Ryan, R. (2012). Position of the Third Na+ Site in the Aspartate Transporter GltPh and the Human Glutamate Transporter, EAAT1. PLoS One, 7(3), 1-10. [More Information]
  • Scott, H., Gebhardt, F., Mitrovic, A., Vandenberg, R., Dodd, P. (2011). Glutamate Transporter Variants Reduce Glutamate Uptake in Alzheimer's Disease. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 32(3), 553.e1-553.e11. [More Information]
  • Bailey, C., Ryan, R., Theong, A., Ng, C., King, K., Vanslambrouck, J., Auray-Blais, C., Vandenberg, R., Bröer, S., Rasko, J. (2011). Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. Journal of Clinical Investigation, 121(1), 446-453. [More Information]
  • Vandenberg, R., Handford, C., Campbell, E., Ryan, R., Yool, A. (2011). Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. The Biochemical Journal, 439(2), 333-340. [More Information]
  • Gebhardt, F., Mitrovic, A., Gilbert, D., Vandenberg, R., Lynch, J., Dodd, P. (2010). Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2. Journal of Biological Chemistry, 285(41), 31313-31324. [More Information]
  • Connor, M., Vaughan, C., Vandenberg, R. (2010). N-Acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets. British Journal of Pharmacology, 160(8), 1857-1871. [More Information]
  • Jeong, H., Vandenberg, R., Vaughan, C. (2010). N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn. British Journal of Pharmacology, 161(4), 925-935. [More Information]
  • Ryan, R., Kortt, N., Sirivanta, T., Vandenberg, R. (2010). The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1. Journal of Neurochemistry, 114(2), 565-575. [More Information]
  • Edington, A., McKinzie, A., Reynolds, A., Kassiou, M., Ryan, R., Vandenberg, R. (2009). Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. Journal of Biological Chemistry, 284(52), 36424-36430. [More Information]
  • Liu, X., Mitrovic, A., Vandenberg, R. (2009). Glycine transporter 1 associates with cholesterol-rich membrane raft microdomains. Biochemical and Biophysical Research Communications, 384(4), 530-534. [More Information]
  • Habjan, S., Vandenberg, R. (2009). Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids. Neurochemical Research, 34(10), 1738-1747. [More Information]
  • Huang, S., Ryan, R., Vandenberg, R. (2009). The Role of Cation Binding in Determining Substrate Selectivity of Glutamate Transporters. Journal of Biological Chemistry, 284(7), 4510-4515. [More Information]
  • Vandenberg, R., Huang, S., Ryan, R. (2008). Slips, leaks and channels in glutamate transporters. Channels, 2(1), 51-58. [More Information]
  • Yang, Z., Aubrey, K., Alroy, I., Harvey, R., Vandenberg, R., Lynch, J. (2008). Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology, 76(8), 1014-1023. [More Information]
  • Vandenberg, R., Shaddick, K., Ju, P. (2007). Molecular basis for substrate discrimination by glycine transporters. Journal of Biological Chemistry, 282(19), 14447-14453. [More Information]
  • Huang, S., Vandenberg, R. (2007). Mutations in Transmembrane Domains 5 and 7 of the Human Excitatory Amino Acid Transporter 1 Affect the Substrate-Activated Anion Channel. Biochemistry, 46(34), 9685-9692. [More Information]
  • Vandenberg, R. (2006). Mutational analysis of glutamate transporters. Handbook of experimental pharmacology, 175(175), 113-35. [More Information]
  • Wiles, A., Pearlman, R., Rosvall, M., Aubrey, K., Vandenberg, R. (2006). N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry, 99(3), 781-786. [More Information]
  • Ryan, R., Vandenberg, R. (2005). A channel in a transporter. Clinical and Experimental Pharmacology and Physiology, 32(1-2), 1-6. [More Information]
  • Aubrey, K., Vandenberg, R., Clements, J. (2005). Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal, 89(3), 1657-1668. [More Information]
  • Vandenberg, R., Ryan, R. (2005). How and Why Are Channels in Transporters? Signal Transduction Knowledge Environment, 19(280), pe17. [More Information]
  • Vandenberg, R., Ju, P., Aubrey, K., Ryan, R., Mitrovic, A. (2004). Allosteric Modulation Of Neurotransmitter Transporters At Excitatory Synapses. European Journal of Pharmaceutical Sciences, 23(1), 1-11.
  • Liu, L., Markus, I., Vandenberg, R., Neilan, B., Murray, M., Burcher, E. (2004). Molecular Identification And Characterization Of Three Isoforms Of Tachykinin Nk(1)-Like Receptors In The Cane Toad Bufo Marinus. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (Print), 287(3), R575-R585.
  • Ryan, R., Mitrovic, A., Vandenberg, R. (2004). The Chloride Permeation Pathway Of A Glutamate Transporter And Its Proximity To The Glutamate Translocation Pathway. Journal of Biological Chemistry, 279(20), 20742-20751.
  • Ju, P., Aubrey, K., Vandenberg, R. (2004). Zn2+ Inhibits Glycine Transport By Glycine Transporter Subtype 1B. Journal of Biological Chemistry, 279(22), 22983-22991.
  • Pearlman, R., Aubrey, K., Vandenberg, R. (2003). Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry, 84(3), 592-601.
  • Mitrovic, A., Vandenberg, R. (2003). Glutamate transporters: redefining the view of a transporter. Australian Biochemist, 11, 8-11.
  • Ryan, R., Vandenberg, R. (2002). Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1. Journal of Biological Chemistry, 277(16), 13494-13500.
  • El-Hajjmoussa, C., Mitrovic, A., Vandenberg, R., Provis, T., Rae, C., Bubb, W., Balcar, V. (2002). Effects of L-Glutamate Transport Inhibition by a Conformationally Restricted Glutamate Analogue (2S,1’S,2’R)-2-(Carboxycyclopropyl)Glycine (L-CCG III)on Metabolism in Brain Tissue In Vitro Analysed by NMR Spectroscopy. Neurochemical Research, 27, 27-35.
  • Moussa, C., Mitrovic, A., Vandenberg, R., Provis, T., Rae, C., Bubb, W., Balcar, V. (2002). Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1"S,2'R)-2-(Carboxycyclopropyl) glycine (L-CCF III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochemical Research, 27(1), 27-35.
  • Vandenberg, R., Aubrey, K. (2001). Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion on Therapeutic Targets, 5, 507-518.
  • Aubrey, K., Vandenberg, R. (2001). N[3-(4-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology, 134(7), 1429-1436.
  • Poulsen, M., Vandenberg, R. (2001). Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4. The Journal of Physiology, 534, 159-167.
  • Mitrovic, A., Plesko, F., Vandenberg, R. (2001). Zn2+ inhibits the anion conductance of the glutamate transporter EAAT4. Journal of Biological Chemistry, 276, 26071-26076.

Conferences

  • Liu, L., Markus, I., Vandenberg, R., Murray, M., Burcher, E. (2003). Distribution, expression and functional activity of three tachykinin NK1 receptor isoforms from Bufo Marinus. Society for Neuroscience, Washington DC: Society for Neuroscience.

2014

  • Carland, J., Handford, C., Ryan, R., Vandenberg, R. (2014). Lipid Inhibitors of High Affinity Glycine Transporters: Identification of a novel class of analgesics. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry, 73, 211-216. [More Information]
  • Scopelliti, A., Heinzelmann, G., Kuyucak, S., Ryan, R., Vandenberg, R. (2014). Na+ interactions with the neutral amino acid transporter. The Journal of Biological Chemistry, 289(25), 17468-17479. [More Information]

2013

  • Carland, J., Edington, A., Scopelliti, A., Ryan, R., Vandenberg, R. (2013). Directed Mutagenesis in Structure Activity Studies of Neurotransmitter Transporters. In David Figurski (Eds.), Genetic Manipulation of DNA and Protein - Examples from Current Research, (pp. 167-184). Rijeka: InTech Publishers.
  • Vandenberg, R., Ryan, R. (2013). Mechanisms of glutamate transport. Physiological Reviews, 93(4), 1621-1657. [More Information]
  • Scopelliti, A., Ryan, R., Vandenberg, R. (2013). Molecular Determinants for Functional Differences between Alanine-Serine-Cysteine Transporter 1 and Other Glutamate Transporter Family Members. The Journal of Biological Chemistry, 288(12), 8250-8257. [More Information]
  • Carland, J., Mansfield, R., Ryan, R., Vandenberg, R. (2013). Oleoyl-L-carnitine inhibits glycine transport by GlyT2. British Journal of Pharmacology, 168(4), 891-902. [More Information]

2012

  • Bastug, T., Heinzelmann, G., Kuyucak, S., Salim, M., Vandenberg, R., Ryan, R. (2012). Position of the Third Na+ Site in the Aspartate Transporter GltPh and the Human Glutamate Transporter, EAAT1. PLoS One, 7(3), 1-10. [More Information]

2011

  • Scott, H., Gebhardt, F., Mitrovic, A., Vandenberg, R., Dodd, P. (2011). Glutamate Transporter Variants Reduce Glutamate Uptake in Alzheimer's Disease. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 32(3), 553.e1-553.e11. [More Information]
  • Bailey, C., Ryan, R., Theong, A., Ng, C., King, K., Vanslambrouck, J., Auray-Blais, C., Vandenberg, R., Bröer, S., Rasko, J. (2011). Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. Journal of Clinical Investigation, 121(1), 446-453. [More Information]
  • Vandenberg, R., Handford, C., Campbell, E., Ryan, R., Yool, A. (2011). Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. The Biochemical Journal, 439(2), 333-340. [More Information]

2010

  • Gebhardt, F., Mitrovic, A., Gilbert, D., Vandenberg, R., Lynch, J., Dodd, P. (2010). Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2. Journal of Biological Chemistry, 285(41), 31313-31324. [More Information]
  • Connor, M., Vaughan, C., Vandenberg, R. (2010). N-Acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets. British Journal of Pharmacology, 160(8), 1857-1871. [More Information]
  • Jeong, H., Vandenberg, R., Vaughan, C. (2010). N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn. British Journal of Pharmacology, 161(4), 925-935. [More Information]
  • McKinzie, A., Ryan, R., Vandenberg, R. (2010). Site-Directed Mutagenesis in the Study of Membrane Transporters. In Qing Yan (Eds.), Membrane Transporters in Drug Discovery and Development: Methods and Protocols - Methods in Molecular Biology Volume 637, (pp. 277-293). New York: Humana Press.
  • Ryan, R., Kortt, N., Sirivanta, T., Vandenberg, R. (2010). The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1. Journal of Neurochemistry, 114(2), 565-575. [More Information]

2009

  • Edington, A., McKinzie, A., Reynolds, A., Kassiou, M., Ryan, R., Vandenberg, R. (2009). Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. Journal of Biological Chemistry, 284(52), 36424-36430. [More Information]
  • Liu, X., Mitrovic, A., Vandenberg, R. (2009). Glycine transporter 1 associates with cholesterol-rich membrane raft microdomains. Biochemical and Biophysical Research Communications, 384(4), 530-534. [More Information]
  • Habjan, S., Vandenberg, R. (2009). Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids. Neurochemical Research, 34(10), 1738-1747. [More Information]
  • Huang, S., Ryan, R., Vandenberg, R. (2009). The Role of Cation Binding in Determining Substrate Selectivity of Glutamate Transporters. Journal of Biological Chemistry, 284(7), 4510-4515. [More Information]

2008

  • Vandenberg, R., Huang, S., Ryan, R. (2008). Slips, leaks and channels in glutamate transporters. Channels, 2(1), 51-58. [More Information]
  • Yang, Z., Aubrey, K., Alroy, I., Harvey, R., Vandenberg, R., Lynch, J. (2008). Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology, 76(8), 1014-1023. [More Information]

2007

  • Vandenberg, R., Shaddick, K., Ju, P. (2007). Molecular basis for substrate discrimination by glycine transporters. Journal of Biological Chemistry, 282(19), 14447-14453. [More Information]
  • Huang, S., Vandenberg, R. (2007). Mutations in Transmembrane Domains 5 and 7 of the Human Excitatory Amino Acid Transporter 1 Affect the Substrate-Activated Anion Channel. Biochemistry, 46(34), 9685-9692. [More Information]

2006

  • Vandenberg, R. (2006). Mutational analysis of glutamate transporters. Handbook of experimental pharmacology, 175(175), 113-35. [More Information]
  • Wiles, A., Pearlman, R., Rosvall, M., Aubrey, K., Vandenberg, R. (2006). N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry, 99(3), 781-786. [More Information]

2005

  • Ryan, R., Vandenberg, R. (2005). A channel in a transporter. Clinical and Experimental Pharmacology and Physiology, 32(1-2), 1-6. [More Information]
  • Aubrey, K., Vandenberg, R., Clements, J. (2005). Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal, 89(3), 1657-1668. [More Information]
  • Vandenberg, R., Ryan, R. (2005). How and Why Are Channels in Transporters? Signal Transduction Knowledge Environment, 19(280), pe17. [More Information]

2004

  • Vandenberg, R., Ju, P., Aubrey, K., Ryan, R., Mitrovic, A. (2004). Allosteric Modulation Of Neurotransmitter Transporters At Excitatory Synapses. European Journal of Pharmaceutical Sciences, 23(1), 1-11.
  • Liu, L., Markus, I., Vandenberg, R., Neilan, B., Murray, M., Burcher, E. (2004). Molecular Identification And Characterization Of Three Isoforms Of Tachykinin Nk(1)-Like Receptors In The Cane Toad Bufo Marinus. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (Print), 287(3), R575-R585.
  • Ryan, R., Mitrovic, A., Vandenberg, R. (2004). The Chloride Permeation Pathway Of A Glutamate Transporter And Its Proximity To The Glutamate Translocation Pathway. Journal of Biological Chemistry, 279(20), 20742-20751.
  • Ju, P., Aubrey, K., Vandenberg, R. (2004). Zn2+ Inhibits Glycine Transport By Glycine Transporter Subtype 1B. Journal of Biological Chemistry, 279(22), 22983-22991.

2003

  • Pearlman, R., Aubrey, K., Vandenberg, R. (2003). Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry, 84(3), 592-601.
  • Liu, L., Markus, I., Vandenberg, R., Murray, M., Burcher, E. (2003). Distribution, expression and functional activity of three tachykinin NK1 receptor isoforms from Bufo Marinus. Society for Neuroscience, Washington DC: Society for Neuroscience.
  • Mitrovic, A., Vandenberg, R. (2003). Glutamate transporters: redefining the view of a transporter. Australian Biochemist, 11, 8-11.
  • Ryan, R., Mitrovic, A., Vandenberg, R. (2003). Site-directed mutagenesis in the study of membrane transportes. In Qing Yan (Eds.), Membrane Transporters: Methods and Protocols (Methods in Molecular Biology Vol. 227), (pp. 97-108). New Jersey, USA: Humana Press.

2002

  • Ryan, R., Vandenberg, R. (2002). Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1. Journal of Biological Chemistry, 277(16), 13494-13500.
  • El-Hajjmoussa, C., Mitrovic, A., Vandenberg, R., Provis, T., Rae, C., Bubb, W., Balcar, V. (2002). Effects of L-Glutamate Transport Inhibition by a Conformationally Restricted Glutamate Analogue (2S,1’S,2’R)-2-(Carboxycyclopropyl)Glycine (L-CCG III)on Metabolism in Brain Tissue In Vitro Analysed by NMR Spectroscopy. Neurochemical Research, 27, 27-35.
  • Moussa, C., Mitrovic, A., Vandenberg, R., Provis, T., Rae, C., Bubb, W., Balcar, V. (2002). Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1"S,2'R)-2-(Carboxycyclopropyl) glycine (L-CCF III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochemical Research, 27(1), 27-35.

2001

  • Vandenberg, R., Aubrey, K. (2001). Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion on Therapeutic Targets, 5, 507-518.
  • Aubrey, K., Vandenberg, R. (2001). N[3-(4-fluorophenyl)-3-(4'-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology, 134(7), 1429-1436.
  • Poulsen, M., Vandenberg, R. (2001). Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4. The Journal of Physiology, 534, 159-167.
  • Mitrovic, A., Plesko, F., Vandenberg, R. (2001). Zn2+ inhibits the anion conductance of the glutamate transporter EAAT4. Journal of Biological Chemistry, 276, 26071-26076.

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