Professor Roger Reddel

BSc(Med), MBBS, FRACP, PhD, FAA
Sir Lorimer Dods Professor, Sydney Medical School
Director, Children's Medical Research Institute (CMRI)
Head, Cancer Research Unit, CMRI

Telephone +61 2 8865 2901
Fax +61 2 8865 2860

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Biographical details

Professor Roger Reddel is a medical oncologist, molecular geneticist and an internationally renowned expert on cancer cell immortalisation. He is Director of Children’s Medical Research Institute (CMRI), Westmead and a Fellow of the Australian Academy of Sciences. His research career on the cellular and molecular biology of immortalisation commenced as a postdoctoral scientist (Fulbright Fellow) at the National Cancer Institute, Maryland, USA, where he improved techniques for immortalisation of human cells in vitro and made the key finding that immortalisation is necessary for malignant transformation of human cells. He returned to Australia to establish and head the Cancer Research Unit at CMRI, with a fellowship from Cancer Council NSW, which has provided major support ever since. He is internationally recognised for research on the enzyme telomerase and for discovering ALT (Alternative Lengthening of Telomeres), which together contribute to unlimited growth in >95% of cancers. His team has made additional seminal findings regarding ALT and the manner in which it is repressed in normal (non-cancer) cells, and identified a molecular marker for ALT that is being developed as a blood test to detect ALT-positive tumours. Overall his research aims to help develop anti-cancer treatments that would work by blocking immortalisation, and tests for detecting signs of cellular immortalisation for early detection of cancer. Professor Reddel has won numerous awards including the Ramaciotti Medal for Excellence in Biomedical Research (2007) and the 2011 NSW Premier's Award for Outstanding Cancer Researcher of the Year. He was a founding member of the University of Sydney's Cancer Research Network and chaired its Translational Research Committee. He is a member of the Executive Management Group of the Kids Cancer Alliance, which brings together leading paediatric medical oncologists and scientists across NSW, to facilitate the translation of basic research toward improved clinical management of children with cancer.

Research interests

Professor Reddel’s research on the molecular genetics of cancer cell immortalisation focuses on the processes by which telomeres in cancer cells remain lengthened thereby facilitating evasion of senescence, i.e. studies on the enzyme telomerase and an alternative mechanism of lengthening of telomeres (ALT). The latter field of research was created after his team’s discovery of ALT in human cell lines, tumour-derived cell lines and in tumours. His team has since made major findings including: the discovery of a novel type of PML body in ALT cells that enables diagnosis of ALT by immunostaining of routine tumour sections; demonstration of ALT activation due to loss of repressor gene(s); cloning of the human telomerase catalytic subunit, hTERT (with an Australian consortium led by Dr Andrzej Kilian, Canberra); first definitive identification of the subunits of active human telomerase enzyme; showing that the presence of ALT activity is a strong predictor of outcome for high-grade brain tumours; discovery of a molecular marker that is rapidly responsive to changes in ALT activity (being developed into a blood test for the presence of ALT-positive tumours and as a rapid assay for screening chemical compounds for anti-ALT activity).

Ongoing research remains focused on investigating the molecular mechanisms of ALT and how it is repressed in normal cells, finding the counterpart of ALT in normal tissues, developing assays to help identify ALT-inhibiting drugs, optimising methods for ALT detection in tumours (for routine use in pathology laboratories), and studies of the prevalence and prognostic significance of ALT in human cancer. Translational research projects through the Kids Cancer Alliance are investigating the genetics and clinical features of Short Telomere Syndrome and the association between telomere length and the side effects of cancer treatment.

Associations

American Association for Cancer Research

Australian Society for Biochemistry and Molecular Biology

Australian Society for Medical Research

Australian and New Zealand Society for Cell and Developmental Biology

European Association for Cancer Research

Australasian Sarcoma Study Group

Awards and honours

Premier's Award for Outstanding Cancer Researcher of the Year 2011

Fellow of Australian Academy of Science 2010

Ramaciotti Medal for Excellence in Biomedical Research 2007

NHMRC Senior Principal Research Fellowship, 2004-2007

Rotary Australia Award for Vocational Excellence, 2003

Aspen Cancer Conference Young Investigator Award, July 1987

Fulbright Postdoctoral Fellowship, 1984-1985

C. J. Martin Fellowship of the National Health and Medical Research Council, Australia, 1984-1986

Harry J. Clayton Memorial Prize for Medicine and Clinical Medicine, University of Sydney, 1976

Harold John Ritchie Memorial Prize (shared) for Medicine, University of Sydney, 1976

Cedric Swanton Memorial Prize for Psychiatry (shared), University of Sydney, 1975

Peter Bancroft Prize (shared) for best undergraduate or postgraduate research in Faculty of Medicine, University of Sydney, 1974

Selected grants

2015

  • ALT-associated PML Bodies: Keys to the biology and treatment of an important subset of cancers; Reddel R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • High content screening (HCS) in-cell imaging system; Robinson P, Chircop (nee Fabbro) M, Reddel R, Bryan T, Cesare A; DVC Research/Equipment Grant.

2014

  • Telomere length analysis for assessing risk of melanoma, other cancers and chronic diseases $150,000; Reddel R; DVC Research/HMR+ Implementation Fund - MRI.
  • Activation of TERT in breast cancer; Reddel R, Beesley J, French J, Pickett H, Huschtscha-Holliday L, Cloonan N; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Automated in situ analysis capacity for translational cancer research; Byrne J, Reddel R, Haber M, Norris M, deFazio A; Cancer Institute New South Wales/Equipment Grant.
  • A novel mechanism for sustained proliferation of cancer cells; Reddel R, Lau L; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Fluidigm BioMark HD - HX; Alexander I, Jamieson R, Chircop (nee Fabbro) M, Byrne J, Catchpoole D, Reddel R, Tam P, Robinson P, Bryan T, Diefenbach R; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Molecular characterisation of telomere trimming and its role in cell proliferative capacity; Reddel R, Pickett H; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Interaction of TRF2 with DNA repair proteins in Alternative Lengthening of Telomeres; Braithwaite A, Reddel R, Lau L; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Telomere structural abnormalities in cells using alternative lengthening of teleomeres; Reddel R, Pickett H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Role of STC1 and STC2 in breast carcinogenesis; Reddel R, Chang A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Induction of senescence in cells that use the Alternative Lengthening of Telomeres (ALT) mechanism; Reddel R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Deltavision (DV) Core Image Restoration; Cunningham A, Turville S, Clarke C, Henderson B, Kefford R, North K, O'Neill G, Murray R, Reddel R, Tam P, Robinson P, Chircop M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • Flow Cytometry support; Alexander S, Braithwaite A, Bradstock K, Bendall L, Gunning P, Henderson B, Kefford R, Reddel R, Rizos H, Jones C, Byrne J; Cancer Institute New South Wales/Infrastructure Grant.

Selected publications

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Book Chapters

  • Pickett, H., Reddel, R. (2009). Alternative lengthening of telomeres in human cells. In Keiko Hiyama (Eds.), Telomeres and Telomerase in Cancer, (pp. 127-148). New York: Springer.
  • Jiang, W., Henson, J., Neumann, A., Reddel, R. (2009). Protocol III: Detection of alternative lengthening of telomeres. In Keiko Hiyama (Eds.), Telomeres and Telomerase in Cancer, (pp. 351-364). New York: Springer.
  • Cesare, A., Reddel, R. (2008). Alternative Lengthening of Telomeres in Mammalian Cells. In Josef Nosek and Lubomir Tomaska (Eds.), Origin and Evolution of Telomeres, (pp. 45-57). United States: Landes Biosciences.
  • Neumann, A., Reddel, R. (2006). Telomerase independent maintenance of mammalian telomeres. In Titia De Lange, Vicki Lundblad, Elizabeth H. Blackburn (Eds.), Telomeres and Telomerase, (pp. 163-198). Michigan: Cold Spring Harbor Laboratory Press.
  • Toouli, C., Reddel, R. (2003). Telomeres and cellular ageing. In S.C. Kaul and R. Wadhwa (Eds.), Aging of Cells In and Outside the Body, (pp. 171-205). US: Kluwer Academic Publishers.
  • Fasching, C., Reddel, R. (2002). Telomere maintenance in human cell lines and tumors without telomerase. In Guido Krupp and Reza Parwaresch (Eds.), Telomeres and telomerases: Cancer and Biology, (pp. 359-373). Georgetown, Texas, USA: Landes Biosciences.

Journals

  • Guo, Y., Kartawinata, M., Li, J., Pickett, H., Teo, J., Kilo, T., Barbaro, P., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R., Christodoulou, J., Bryan, T., et al (2014). Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood, 124(18), 2767-2774. [More Information]
  • Singh, R., Kalra, R., Hasan, K., Kaul, Z., Cheung, C., Huschtscha, L., Reddel, R., Kaul, S., Wadhwa, R. (2014). Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein. Experimental Cell Research, 322(2), 324-334. [More Information]
  • Conomos, D., Reddel, R., Pickett, H. (2014). NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nature Structural and Molecular Biology, 21(9), 760-770. [More Information]
  • Gupta, R., Dong, Y., Solomon, P., Wettersten, H., Cheng, C., Min, J., Henson, J., Dogra, S., Hwang, S., Hammock, B., Reddel, R., et al (2014). Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111(30), E3062-E3071. [More Information]
  • Lee, M., Hills, M., Conomos, D., Stutz, M., Dagg, R., Lau, L., Reddel, R., Pickett, H. (2014). Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Research, 42(3), 1733-1746. [More Information]
  • Reddel, R. (2014). Telomere maintenance mechanisms in cancer: clinical implications. Current Pharmaceutical Design, 20(41), 6361-6374.
  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Devleopment, 27(1), 18-23. [More Information]
  • Conomos, D., Pickett, H., Reddel, R. (2013). Alternative lengthening of telomeres: remodeling the telomere architecture. Frontiers in Oncology, 3, 1-7. [More Information]
  • Lau, L., Dagg, R., Henson, J., Au, A., Royds, J., Reddel, R. (2013). Detection of alternative lengthening of telomeres by telomere quantitative PCR. Nucleic Acids Research, 41(2), 1-9. [More Information]
  • Bojesen, S., Pooley, K., Johnatty, S., Beesley, J., Michailidou, K., Tyrer, J., Edwards, S., Pickett, H., Shen, H., Smart, C., Stutz, M., Reddel, R., et al (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics, 45(4), 371-384. [More Information]
  • Durukan Tolvanen, A., Westberg, J., Serlachius, M., Chang, A., Reddel, R., Andersson, L., Tatlisumak, T. (2013). Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance. Neuroscience, 229, 49-54. [More Information]
  • Pena, C., Cespedes, M., Lindh, M., Kiflemariam, S., Mezheyeuski, A., Edqvist, P., Hagglof, C., Birgisson, H., Bojmar, L., Jirstrom, L., Chang, A., Reddel, R., et al (2013). STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer. Cancer Research, 73(4), 1287-1297. [More Information]
  • Shay, J., Reddel, R., Wright, W. (2012). Cancer and Telomeres - An ALTernative to Telomerase. Science, 336(6087), 1388-1390. [More Information]
  • Huschtscha-Holliday, L., Napier, C., Noble, J., Bower, K., Au, A., Campbell, H., Braithwaite, A., Reddel, R. (2012). Enhanced isolation of fibroblasts from human skin explants. BioTechniques: the journal of laboratory technology for bioresearch, 53(4), 239-244. [More Information]
  • Bender, H., Murchison, E., Pickett, H., Deakin, J., Strong, M., Conlan, C., McMillan, D., Neumann, A., Greider, C., Hannon, G., Reddel, R., et al (2012). Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PloS One, 7(9), 1-10. [More Information]
  • Kaul, Z., Cesare, A., Huschtscha, L., Neumann, A., Reddel, R. (2012). Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Reports, 13(1), 52-59. [More Information]
  • Lovejoy, C., Li, W., Reisenweber, S., Thongthip, S., Bruno, J., De Lange, T., De, S., Petrini, J., Sung, P., Jasin, M., Reddel, R., et al (2012). Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway. PLoS Genetics, 8(7), 1-16. [More Information]
  • Bower, K., Napier, C., Cole, S., Dagg, R., Lau, L., Duncan, E., Moy, E., Reddel, R. (2012). Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres. PloS One, 7(11), 1-10. [More Information]
  • Pickett, H., Reddel, R. (2012). The role of telomere trimming in normal telomere length dynamics. Cell Cycle, 11(7), 1309-1315. [More Information]
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012). Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology, 199(6), 893-906. [More Information]
  • Beesley, J., Pickett, H., Johnatty, S., Dunning, A., Chen, X., Li, J., Michailidou, K., Lu, Y., Rider, D., Palmieri, R., Stutz, M., Reddel, R., et al (2011). Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PloS One, 6(9), 1-6. [More Information]
  • Jiang, W., Nguyen, A., Cao, Y., Chang, A., Reddel, R. (2011). HP1-Mediated Formation of Alternative Lengthening of Telomeres-Associated PML Bodies Requires HIRA but Not ASF1a. PloS One, 6(2), e17036-1-e17036-12. [More Information]
  • Yoon, A., Gao, R., Kaul, Z., Choi, I., Ryu, J., Noble, J., Kato, Y., Saito, S., Hirano, T., Ishii, T., Reddel, R., et al (2011). MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Research, 39(18), 8078-8091. [More Information]
  • Pickett, H., Henson, J., Au, A., Neumann, A., Reddel, R. (2011). Normal mammalian cells negatively regulate telomere length by telomere trimming. Human Molecular Genetics, 20(23), 4684-4692. [More Information]
  • Au, A., Hackl, T., Yeager, T., Cohen, S., Pass, H., Harris, C., Reddel, R. (2011). Telomerase activity in pleural malignant mesotheliomas. Lung Cancer, 73(3), 283-288. [More Information]
  • Cesare, A., Reddel, R. (2010). Alternative lengthening of telomeres: models, mechanisms and implications. Nature reviews. Genetics, 11(5), 319-30. [More Information]
  • Henson, J., Reddel, R. (2010). Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers. FEBS Letters, 584(17), 3800-11. [More Information]
  • Capes-Davis, A., Atkin, I., Drexler, H., Kohara, A., Macleod, R., Masters, J., Nakamura, Y., Reid, Y., Reddel, R., Freshney, R. (2010). Check your cultures! A list of cross-contaminated or misidentified cell lines. International Journal of Cancer, 127(1), 1-8. [More Information]
  • McDonald, K., McDonnell, J., Muntoni, A., Henson, J., Hegi, M., von Deimling, A., Wheeler, H., Cook, R., Biggs, M., Little, N., Robinson, B., Reddel, R., et al (2010). Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival. Journal of Neuropathology and Experimental Neurology, 69(7), 729-736. [More Information]
  • Reddel, R. (2010). Senescence: an antiviral defense that is tumor suppressive? Carcinogenesis, 31(1), 19-26. [More Information]
  • Hinshelwood, R., Melki, J., Huschtscha, L., Paul, C., Song, J., Stirzaker, C., Reddel, R., Clark, S. (2009). Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning. Human Molecular Genetics, 18(16), 3098-3109. [More Information]
  • Pickett, H., Cesare, A., Johnston, R., Neumann, A., Reddel, R. (2009). Control of telomere length by a trimming mechanism that involves generation of t-circles. The EMBO Journal, 28(7), 799-809. [More Information]
  • Henson, J., Cao, Y., Huschtscha-Holliday, L., Chang, A., Au, A., Pickett, H., Reddel, R. (2009). DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nature Biotechnology, 27(12), 1181-1185. [More Information]
  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Jiang, W., Zhong, Z., Nguyen, A., Henson, J., Toouli, C., Braithwaite, A., Reddel, R. (2009). Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. The Journal of Cell Biology, 185(5), 797-810. [More Information]
  • Huschtscha-Holliday, L., Moore, J., Noble, J., Campbell, H., Royds, J., Braithwaite, A., Reddel, R. (2009). Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. Journal of Cell Science, 122(16), 2989-2995. [More Information]
  • Cesare, A., Kaul, Z., Cohen, S., Napier, C., Pickett, H., Neumann, A., Reddel, R. (2009). Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nature Structural and Molecular Biology, 16(12), 1244-1251. [More Information]
  • Nguyen, A., Chang, A., Reddel, R. (2009). Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress. Oncogene, 28(18), 1982-1992. [More Information]
  • Ng, L., Cropley, J., Pickett, H., Reddel, R., Suter, C. (2009). Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Research, 37(4), 1152-1159. [More Information]
  • Muntoni, A., Neumann, A., Hills, M., Reddel, R. (2009). Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres. Human Molecular Genetics, 18(6), 1017-1027. [More Information]
  • Yuan, J., Yang, B., Zhong, Z., Shatts, I., Milyavski, M., Rotter, V., Lock, R., Reddel, R., Mackenzie, K. (2009). Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. Oncogene, 28(29), 2678-2689. [More Information]
  • Cohen, S., Reddel, R. (2008). A sensitive direct human telomerase activity assay. Nature Methods, 5(4), 355-360. [More Information]
  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008). Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels. Cancer Research, 68(9), 3115-3123. [More Information]
  • Cao, Y., Bryan, T., Reddel, R. (2008). Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer science, 99(6), 1092-1099. [More Information]
  • Villa, R., Daidone, M., Motta, R., Venturini, L., De Marco, C., Vannelli, A., Kusamura, S., Baratti, D., Deraco, M., Costa, A., Reddel, R., et al (2008). Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma. Clinical Cancer Research, 14(13), 4134-4140. [More Information]
  • Chen, Y., Campbell, H., Wiles, A., Eccles, M., Reddel, R., Braithwaite, A., Royds, J. (2008). PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research, 68(14), 5724-5732. [More Information]
  • Cesare, A., Reddel, R. (2008). Telomere uncapping and alternative lengthening of telomeres. Mechanisms of ageing and development, 129(1-2), 99-108. [More Information]
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008). The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology, 149(5), 2403-2410. [More Information]
  • Reddel, R. (2007). A SUMO ligase for ALT. Nature Structural and Molecular Biology, 14(7), 570-571. [More Information]
  • Hinshelwood, R., Huschtscha, L., Melki, J., Stirzaker, C., Abdipranoto, A., Vissel, B., Ravasi, T., Wells, C., Hume, D., Reddel, R., et al (2007). Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Research, 67(24), 11517-11527. [More Information]
  • Zhong, Z., Jiang, W., Cesare, A., Neumann, A., Wadhwa, R., Reddel, R. (2007). Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. Journal of Biological Chemistry, 282(40), 29314-29322. [More Information]
  • Fasching, C., Neumann, A., Muntoni, A., Yeager, T., Reddel, R. (2007). DNA Damage Induces Alternative Lengthening of Telomeres (ALT) Associated Promyelocytic Leukemia Bodies that Preferentially Associate with Linear Telomeric DNA. Cancer Research, 67(15), 7072-7077. [More Information]
  • Jiang, W., Zhong, Z., Henson, J., Reddel, R. (2007). Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference. Oncogene, 26(32), 4635-4647. [More Information]
  • Cohen, S., Graham, M., Lovrecz, G., Bache, N., Robinson, P., Reddel, R. (2007). Protein composition of catalytically active human telomerase from immortal cells. Science, 315(5820), 1850-1853. [More Information]
  • Chen, Y., Hakin-Smith, V., Teo, M., Xinarianos, G., Jellinek, D., Carroll, T., McDowell, D., MacFarlane, M., Boet, R., Baguley, B., Braithwaite, A., Reddel, R., et al (2006). Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Research, 66(13), 6473-6476. [More Information]
  • Costa, A., Daidone, M., Daprai, L., Villa, R., Cantù, S., Pilotti, S., Mariani, L., Gronchi, A., Henson, J., Reddel, R., et al (2006). Telomere maintenance mechanisms in liposarcomas: association with histologic subtypes and disease progression. Cancer Research, 66(17), 8918-8924. [More Information]
  • Wadhwa, R., Takano, S., Kaur, K., Deocaris, C., Pereira-Smith, O., Reddel, R., Kaul, S. (2006). Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. International Journal of Cancer, 118(12), 2973-2980. [More Information]
  • Henson, J., Hannay, J., McCarthy, S., Royds, J., Yeager, T., Robinson, R., Wharton, S., Jellinek, D., Arbuckle, S., Yoo, J., Robinson, B., Learoyd, D., Reddel, R., et al (2005). A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clinical Cancer Research, 11(1), 217-225. [More Information]
  • Jeyapalan, J., Varley, H., Foxon, J., Pollock, R., Jeffreys, A., Henson, J., Reddel, R., Royle, N. (2005). Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome. Human Molecular Genetics, 14(13), 1785-1794. [More Information]
  • Moran-Jones, K., Wayman, L., Kennedy, D., Reddel, R., Sara, S., Snee, M., Smith, R. (2005). hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere. Nucleic Acids Research, 33(2), 486-496. [More Information]
  • Jiang, W., Zhong, Z., Henson, J., Neumann, A., Chang, A., Reddel, R. (2005). Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex. Molecular and Cellular Biology, 25(7), 2708-2721. [More Information]
  • Fasching, C., Bower, K., Reddel, R. (2005). Telomerase-Independent Telomere Length Maintenance in the Absence of Alternative Lengthening of Telomeres–Associated Promyelocytic Leukemia Bodies. Cancer Research, 65(7), 2722-2729. [More Information]
  • Muntoni, A., Reddel, R. (2005). The first molecular details of ALT in human tumor cells. Human Molecular Genetics, 14(Review Issue 2), R191-R196. [More Information]
  • Chang, A., Cha, J., Koentgen, F., Reddel, R. (2005). The murine stanniocalcin 1 gene is not essential for growth and development. Molecular and Cellular Biology, 25(23), 10604-10610. [More Information]
  • Noble, J., Zhong, Z., Neumann, A., Melki, J., Clark, S., Reddel, R. (2004). Alterations In The P16(Ink4A) And P53 Tumor Suppressor Genes Of Htert-Immortalized Human Fibroblasts. Oncogene, 23(17), 3116-3121.
  • Londono-Vallejo, J., Der-Sarkissian, H., Cazes, L., Bacchetti, S., Reddel, R. (2004). Alternative Lengthening Of Telomeres Is Characterized By High Rates Of Telomeric Exchange. Cancer Research, 64(7), 2324-2327.
  • Colgin, L., Reddel, R. (2004). Telomere Biology: A New Player In The Dispatch End Zone. Current Biology, 14(20), R901-R902. [More Information]
  • Hakin-Smith, V., Jellinek, D., Levy, D., Carroll, T., Teo, M., Timperley, W., McKay, M., Reddel, R., Royds, J. (2003). Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme. The Lancet, 361(9360), 836-838.
  • Reddel, R. (2003). Alternative lengthening of telomeres, telomerase and cancer. Cancer Letters, 194(2), 155-162.
  • Reddel, R., Bryan, T. (2003). Alternative lengthening of telomeres: dangerous road less travelled. The Lancet, 361(9372), 1840-1841.
  • Colgin, L., Baran, K., Baumann, P., Cech, T., Reddel, R. (2003). Human POT1 facilitates telomere elongation by telomerase. Current Biology, 13(11), 942-946.
  • Chang, A., Jellinek, D., Reddel, R. (2003). Mammalian stanniocalcins and cancer. Endocrine-Related Cancer, 10(3), 359-373.
  • Kaul, S., Yaguchi, T., Taira, K., Reddel, R., Wadhwa, R. (2003). Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Experimental Cell Research, 286(1), 96-101.
  • Wadhwa, R., Sugihara, T., Hasan, M., Taira, K., Reddel, R., Kaul, S. (2002). A Major Functional Difference between the mouse and Human ARF Tumor Suppressor proteins. Journal of Biological Chemistry, 277(39), 36665-36670.
  • Henson, J., Neumann, A., Yeager, T., Reddel, R. (2002). Alternative lengthening of telomeres in mammalian cells. Oncogene, 21(4), 598-610.
  • Toouli, C., Huschtscha, L., Neumann, A., Noble, J., Colgin, L., Hukku, B., Reddel, R. (2002). Comparison of human mammary epithelial cells immortalized by simian virus 40 T-antigen or by the telomerase catalytic subunit. Oncogene, 21(1), 128-139.
  • Wadhwa, R., Yaguchi, T., Hasan, M., Mitsui, Y., Reddel, R., Kaul, S. (2002). Hsp70 Family Member, mot-2/mthsp70/GRP75, binds to the Cytoplasmic Sequestration Domain of the P53 Gene. Experimental Cell Research, 274(2), 246-253. [More Information]
  • Varley, H., Pickett, H., Foxon, J., Reddel, R., Royle, N. (2002). Molecular characterisation of inter-telomere and intra-telomere mutations in human ALT cells. Nature Genetics, 30(3), 301-305.
  • Wadhwa, R., Colgin, L., Yaguchi, T., Taira, K., Reddel, R., Kaul, S. (2002). Rhodacyanine Dye MKT-077 Inhibits in Vito Telomerase Assay but has no detectable effects on Telomerase activity in vivo. Cancer Research, 62(15), 4434-4438.
  • Bouras, T., Southey, M., Chang, A., Reddel, R., Willhite, D., Glynne, R., Henderson, M., Armes, J., Venter, D. (2002). Stanniocalcin 2 is an estorgen-responsive gene coexpressed with the estrogen receptor in human breast cancer. Cancer Research, 62(5), 1289-1295.
  • Neumann, A., Reddel, R. (2002). Telomere maintenance and cancer - look, no Telomerase. Nature Reviews Cancer, 2(11), 879-884.
  • Reddel, R., Bryan, T., Colgin, L., Perrem, K., Yeager, T. (2001). Alternative lengthening of telomeres in human cells. Radiation Research, 155(1), 194-200. [More Information]
  • Reddel, R. (2001). An alternative lifestyle for immortalized oral keratinocytes. Journal of Clinical Investigation, 108, 665-667.
  • Reddel, R., Kaul, S., Mitsui,, Y., Wadhwa, R. (2001). An N-Terminal Region of Mot-2 Binds to p53 In Vitro. Neoplasia (Spanish Edition): oncologia multidisciplinaria, 3, 110-114.
  • Perrem, K., Colgin, L., Neumann,, A., Yeager, T., Reddel, R. (2001). Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells. Molecular and Cellular Biology, 21, 3862-3875.
  • Reddel, R., Huschtscha, L., Neumann,, A., Noble,, J. (2001). Effects of Simian Virus 40 T-Antigens on Normal Human Mammary Epithelial Cells Reveal Evidence for Spontaneous Alterations in Addition to Loss of P16INK4a Expression. Experimental Cell Research, 265, 125-134.
  • Reddel, R., Sugihara, T., Kaul, S., Kato, J., Nomura, H., Wadhwa, R. (2001). Pex19p Dampens the p19ARF-p53-p21WAF1 Tumor Suppressor Pathway. Journal of Biological Chemistry, 276, 18649-18652.
  • Reddel, R., Szutorisz, H., Palmqvist, R., Roos, G., Stenling,, R., Schorderet, D., Linger,, J., Nabholz,, M. (2001). Rearrangements of minisatelites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas. Oncogene, 20, 2600-2605.

Reference Works

  • Reddel, R. (2012). Senescence and immortalization. (Vol. 1, pp. 2697-2699).

2014

  • Guo, Y., Kartawinata, M., Li, J., Pickett, H., Teo, J., Kilo, T., Barbaro, P., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R., Christodoulou, J., Bryan, T., et al (2014). Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood, 124(18), 2767-2774. [More Information]
  • Singh, R., Kalra, R., Hasan, K., Kaul, Z., Cheung, C., Huschtscha, L., Reddel, R., Kaul, S., Wadhwa, R. (2014). Molecular characterization of collaborator of ARF (CARF) as a DNA damage response and cell cycle checkpoint regulatory protein. Experimental Cell Research, 322(2), 324-334. [More Information]
  • Conomos, D., Reddel, R., Pickett, H. (2014). NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nature Structural and Molecular Biology, 21(9), 760-770. [More Information]
  • Gupta, R., Dong, Y., Solomon, P., Wettersten, H., Cheng, C., Min, J., Henson, J., Dogra, S., Hwang, S., Hammock, B., Reddel, R., et al (2014). Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111(30), E3062-E3071. [More Information]
  • Lee, M., Hills, M., Conomos, D., Stutz, M., Dagg, R., Lau, L., Reddel, R., Pickett, H. (2014). Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Research, 42(3), 1733-1746. [More Information]
  • Reddel, R. (2014). Telomere maintenance mechanisms in cancer: clinical implications. Current Pharmaceutical Design, 20(41), 6361-6374.

2013

  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Devleopment, 27(1), 18-23. [More Information]
  • Conomos, D., Pickett, H., Reddel, R. (2013). Alternative lengthening of telomeres: remodeling the telomere architecture. Frontiers in Oncology, 3, 1-7. [More Information]
  • Lau, L., Dagg, R., Henson, J., Au, A., Royds, J., Reddel, R. (2013). Detection of alternative lengthening of telomeres by telomere quantitative PCR. Nucleic Acids Research, 41(2), 1-9. [More Information]
  • Bojesen, S., Pooley, K., Johnatty, S., Beesley, J., Michailidou, K., Tyrer, J., Edwards, S., Pickett, H., Shen, H., Smart, C., Stutz, M., Reddel, R., et al (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics, 45(4), 371-384. [More Information]
  • Durukan Tolvanen, A., Westberg, J., Serlachius, M., Chang, A., Reddel, R., Andersson, L., Tatlisumak, T. (2013). Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance. Neuroscience, 229, 49-54. [More Information]
  • Pena, C., Cespedes, M., Lindh, M., Kiflemariam, S., Mezheyeuski, A., Edqvist, P., Hagglof, C., Birgisson, H., Bojmar, L., Jirstrom, L., Chang, A., Reddel, R., et al (2013). STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer. Cancer Research, 73(4), 1287-1297. [More Information]

2012

  • Shay, J., Reddel, R., Wright, W. (2012). Cancer and Telomeres - An ALTernative to Telomerase. Science, 336(6087), 1388-1390. [More Information]
  • Huschtscha-Holliday, L., Napier, C., Noble, J., Bower, K., Au, A., Campbell, H., Braithwaite, A., Reddel, R. (2012). Enhanced isolation of fibroblasts from human skin explants. BioTechniques: the journal of laboratory technology for bioresearch, 53(4), 239-244. [More Information]
  • Bender, H., Murchison, E., Pickett, H., Deakin, J., Strong, M., Conlan, C., McMillan, D., Neumann, A., Greider, C., Hannon, G., Reddel, R., et al (2012). Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PloS One, 7(9), 1-10. [More Information]
  • Kaul, Z., Cesare, A., Huschtscha, L., Neumann, A., Reddel, R. (2012). Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Reports, 13(1), 52-59. [More Information]
  • Lovejoy, C., Li, W., Reisenweber, S., Thongthip, S., Bruno, J., De Lange, T., De, S., Petrini, J., Sung, P., Jasin, M., Reddel, R., et al (2012). Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway. PLoS Genetics, 8(7), 1-16. [More Information]
  • Bower, K., Napier, C., Cole, S., Dagg, R., Lau, L., Duncan, E., Moy, E., Reddel, R. (2012). Loss of Wild-Type ATRX Expression in Somatic Cell Hybrids Segregates with Activation of Alternative Lengthening of Telomeres. PloS One, 7(11), 1-10. [More Information]
  • Reddel, R. (2012). Senescence and immortalization. (Vol. 1, pp. 2697-2699).
  • Pickett, H., Reddel, R. (2012). The role of telomere trimming in normal telomere length dynamics. Cell Cycle, 11(7), 1309-1315. [More Information]
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012). Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology, 199(6), 893-906. [More Information]

2011

  • Beesley, J., Pickett, H., Johnatty, S., Dunning, A., Chen, X., Li, J., Michailidou, K., Lu, Y., Rider, D., Palmieri, R., Stutz, M., Reddel, R., et al (2011). Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PloS One, 6(9), 1-6. [More Information]
  • Jiang, W., Nguyen, A., Cao, Y., Chang, A., Reddel, R. (2011). HP1-Mediated Formation of Alternative Lengthening of Telomeres-Associated PML Bodies Requires HIRA but Not ASF1a. PloS One, 6(2), e17036-1-e17036-12. [More Information]
  • Yoon, A., Gao, R., Kaul, Z., Choi, I., Ryu, J., Noble, J., Kato, Y., Saito, S., Hirano, T., Ishii, T., Reddel, R., et al (2011). MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Research, 39(18), 8078-8091. [More Information]
  • Pickett, H., Henson, J., Au, A., Neumann, A., Reddel, R. (2011). Normal mammalian cells negatively regulate telomere length by telomere trimming. Human Molecular Genetics, 20(23), 4684-4692. [More Information]
  • Au, A., Hackl, T., Yeager, T., Cohen, S., Pass, H., Harris, C., Reddel, R. (2011). Telomerase activity in pleural malignant mesotheliomas. Lung Cancer, 73(3), 283-288. [More Information]

2010

  • Cesare, A., Reddel, R. (2010). Alternative lengthening of telomeres: models, mechanisms and implications. Nature reviews. Genetics, 11(5), 319-30. [More Information]
  • Henson, J., Reddel, R. (2010). Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers. FEBS Letters, 584(17), 3800-11. [More Information]
  • Capes-Davis, A., Atkin, I., Drexler, H., Kohara, A., Macleod, R., Masters, J., Nakamura, Y., Reid, Y., Reddel, R., Freshney, R. (2010). Check your cultures! A list of cross-contaminated or misidentified cell lines. International Journal of Cancer, 127(1), 1-8. [More Information]
  • McDonald, K., McDonnell, J., Muntoni, A., Henson, J., Hegi, M., von Deimling, A., Wheeler, H., Cook, R., Biggs, M., Little, N., Robinson, B., Reddel, R., et al (2010). Presence of Alternative Lengthening of Telomeres Mechanism in Patients With Glioblastoma Identifies a Less Aggressive Tumor Type With Longer Survival. Journal of Neuropathology and Experimental Neurology, 69(7), 729-736. [More Information]
  • Reddel, R. (2010). Senescence: an antiviral defense that is tumor suppressive? Carcinogenesis, 31(1), 19-26. [More Information]

2009

  • Hinshelwood, R., Melki, J., Huschtscha, L., Paul, C., Song, J., Stirzaker, C., Reddel, R., Clark, S. (2009). Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning. Human Molecular Genetics, 18(16), 3098-3109. [More Information]
  • Pickett, H., Reddel, R. (2009). Alternative lengthening of telomeres in human cells. In Keiko Hiyama (Eds.), Telomeres and Telomerase in Cancer, (pp. 127-148). New York: Springer.
  • Pickett, H., Cesare, A., Johnston, R., Neumann, A., Reddel, R. (2009). Control of telomere length by a trimming mechanism that involves generation of t-circles. The EMBO Journal, 28(7), 799-809. [More Information]
  • Henson, J., Cao, Y., Huschtscha-Holliday, L., Chang, A., Au, A., Pickett, H., Reddel, R. (2009). DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nature Biotechnology, 27(12), 1181-1185. [More Information]
  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Jiang, W., Zhong, Z., Nguyen, A., Henson, J., Toouli, C., Braithwaite, A., Reddel, R. (2009). Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. The Journal of Cell Biology, 185(5), 797-810. [More Information]
  • Huschtscha-Holliday, L., Moore, J., Noble, J., Campbell, H., Royds, J., Braithwaite, A., Reddel, R. (2009). Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. Journal of Cell Science, 122(16), 2989-2995. [More Information]
  • Jiang, W., Henson, J., Neumann, A., Reddel, R. (2009). Protocol III: Detection of alternative lengthening of telomeres. In Keiko Hiyama (Eds.), Telomeres and Telomerase in Cancer, (pp. 351-364). New York: Springer.
  • Cesare, A., Kaul, Z., Cohen, S., Napier, C., Pickett, H., Neumann, A., Reddel, R. (2009). Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nature Structural and Molecular Biology, 16(12), 1244-1251. [More Information]
  • Nguyen, A., Chang, A., Reddel, R. (2009). Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress. Oncogene, 28(18), 1982-1992. [More Information]
  • Ng, L., Cropley, J., Pickett, H., Reddel, R., Suter, C. (2009). Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Research, 37(4), 1152-1159. [More Information]
  • Muntoni, A., Neumann, A., Hills, M., Reddel, R. (2009). Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres. Human Molecular Genetics, 18(6), 1017-1027. [More Information]
  • Yuan, J., Yang, B., Zhong, Z., Shatts, I., Milyavski, M., Rotter, V., Lock, R., Reddel, R., Mackenzie, K. (2009). Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase. Oncogene, 28(29), 2678-2689. [More Information]

2008

  • Cohen, S., Reddel, R. (2008). A sensitive direct human telomerase activity assay. Nature Methods, 5(4), 355-360. [More Information]
  • Cesare, A., Reddel, R. (2008). Alternative Lengthening of Telomeres in Mammalian Cells. In Josef Nosek and Lubomir Tomaska (Eds.), Origin and Evolution of Telomeres, (pp. 45-57). United States: Landes Biosciences.
  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008). Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels. Cancer Research, 68(9), 3115-3123. [More Information]
  • Cao, Y., Bryan, T., Reddel, R. (2008). Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer science, 99(6), 1092-1099. [More Information]
  • Villa, R., Daidone, M., Motta, R., Venturini, L., De Marco, C., Vannelli, A., Kusamura, S., Baratti, D., Deraco, M., Costa, A., Reddel, R., et al (2008). Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma. Clinical Cancer Research, 14(13), 4134-4140. [More Information]
  • Chen, Y., Campbell, H., Wiles, A., Eccles, M., Reddel, R., Braithwaite, A., Royds, J. (2008). PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research, 68(14), 5724-5732. [More Information]
  • Cesare, A., Reddel, R. (2008). Telomere uncapping and alternative lengthening of telomeres. Mechanisms of ageing and development, 129(1-2), 99-108. [More Information]
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008). The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology, 149(5), 2403-2410. [More Information]

2007

  • Reddel, R. (2007). A SUMO ligase for ALT. Nature Structural and Molecular Biology, 14(7), 570-571. [More Information]
  • Hinshelwood, R., Huschtscha, L., Melki, J., Stirzaker, C., Abdipranoto, A., Vissel, B., Ravasi, T., Wells, C., Hume, D., Reddel, R., et al (2007). Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Research, 67(24), 11517-11527. [More Information]
  • Zhong, Z., Jiang, W., Cesare, A., Neumann, A., Wadhwa, R., Reddel, R. (2007). Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. Journal of Biological Chemistry, 282(40), 29314-29322. [More Information]
  • Fasching, C., Neumann, A., Muntoni, A., Yeager, T., Reddel, R. (2007). DNA Damage Induces Alternative Lengthening of Telomeres (ALT) Associated Promyelocytic Leukemia Bodies that Preferentially Associate with Linear Telomeric DNA. Cancer Research, 67(15), 7072-7077. [More Information]
  • Jiang, W., Zhong, Z., Henson, J., Reddel, R. (2007). Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference. Oncogene, 26(32), 4635-4647. [More Information]
  • Cohen, S., Graham, M., Lovrecz, G., Bache, N., Robinson, P., Reddel, R. (2007). Protein composition of catalytically active human telomerase from immortal cells. Science, 315(5820), 1850-1853. [More Information]

2006

  • Chen, Y., Hakin-Smith, V., Teo, M., Xinarianos, G., Jellinek, D., Carroll, T., McDowell, D., MacFarlane, M., Boet, R., Baguley, B., Braithwaite, A., Reddel, R., et al (2006). Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Research, 66(13), 6473-6476. [More Information]
  • Neumann, A., Reddel, R. (2006). Telomerase independent maintenance of mammalian telomeres. In Titia De Lange, Vicki Lundblad, Elizabeth H. Blackburn (Eds.), Telomeres and Telomerase, (pp. 163-198). Michigan: Cold Spring Harbor Laboratory Press.
  • Costa, A., Daidone, M., Daprai, L., Villa, R., Cantù, S., Pilotti, S., Mariani, L., Gronchi, A., Henson, J., Reddel, R., et al (2006). Telomere maintenance mechanisms in liposarcomas: association with histologic subtypes and disease progression. Cancer Research, 66(17), 8918-8924. [More Information]
  • Wadhwa, R., Takano, S., Kaur, K., Deocaris, C., Pereira-Smith, O., Reddel, R., Kaul, S. (2006). Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. International Journal of Cancer, 118(12), 2973-2980. [More Information]

2005

  • Henson, J., Hannay, J., McCarthy, S., Royds, J., Yeager, T., Robinson, R., Wharton, S., Jellinek, D., Arbuckle, S., Yoo, J., Robinson, B., Learoyd, D., Reddel, R., et al (2005). A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas. Clinical Cancer Research, 11(1), 217-225. [More Information]
  • Jeyapalan, J., Varley, H., Foxon, J., Pollock, R., Jeffreys, A., Henson, J., Reddel, R., Royle, N. (2005). Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome. Human Molecular Genetics, 14(13), 1785-1794. [More Information]
  • Moran-Jones, K., Wayman, L., Kennedy, D., Reddel, R., Sara, S., Snee, M., Smith, R. (2005). hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere. Nucleic Acids Research, 33(2), 486-496. [More Information]
  • Jiang, W., Zhong, Z., Henson, J., Neumann, A., Chang, A., Reddel, R. (2005). Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex. Molecular and Cellular Biology, 25(7), 2708-2721. [More Information]
  • Fasching, C., Bower, K., Reddel, R. (2005). Telomerase-Independent Telomere Length Maintenance in the Absence of Alternative Lengthening of Telomeres–Associated Promyelocytic Leukemia Bodies. Cancer Research, 65(7), 2722-2729. [More Information]
  • Muntoni, A., Reddel, R. (2005). The first molecular details of ALT in human tumor cells. Human Molecular Genetics, 14(Review Issue 2), R191-R196. [More Information]
  • Chang, A., Cha, J., Koentgen, F., Reddel, R. (2005). The murine stanniocalcin 1 gene is not essential for growth and development. Molecular and Cellular Biology, 25(23), 10604-10610. [More Information]

2004

  • Noble, J., Zhong, Z., Neumann, A., Melki, J., Clark, S., Reddel, R. (2004). Alterations In The P16(Ink4A) And P53 Tumor Suppressor Genes Of Htert-Immortalized Human Fibroblasts. Oncogene, 23(17), 3116-3121.
  • Londono-Vallejo, J., Der-Sarkissian, H., Cazes, L., Bacchetti, S., Reddel, R. (2004). Alternative Lengthening Of Telomeres Is Characterized By High Rates Of Telomeric Exchange. Cancer Research, 64(7), 2324-2327.
  • Colgin, L., Reddel, R. (2004). Telomere Biology: A New Player In The Dispatch End Zone. Current Biology, 14(20), R901-R902. [More Information]

2003

  • Hakin-Smith, V., Jellinek, D., Levy, D., Carroll, T., Teo, M., Timperley, W., McKay, M., Reddel, R., Royds, J. (2003). Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme. The Lancet, 361(9360), 836-838.
  • Reddel, R. (2003). Alternative lengthening of telomeres, telomerase and cancer. Cancer Letters, 194(2), 155-162.
  • Reddel, R., Bryan, T. (2003). Alternative lengthening of telomeres: dangerous road less travelled. The Lancet, 361(9372), 1840-1841.
  • Colgin, L., Baran, K., Baumann, P., Cech, T., Reddel, R. (2003). Human POT1 facilitates telomere elongation by telomerase. Current Biology, 13(11), 942-946.
  • Chang, A., Jellinek, D., Reddel, R. (2003). Mammalian stanniocalcins and cancer. Endocrine-Related Cancer, 10(3), 359-373.
  • Kaul, S., Yaguchi, T., Taira, K., Reddel, R., Wadhwa, R. (2003). Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Experimental Cell Research, 286(1), 96-101.
  • Toouli, C., Reddel, R. (2003). Telomeres and cellular ageing. In S.C. Kaul and R. Wadhwa (Eds.), Aging of Cells In and Outside the Body, (pp. 171-205). US: Kluwer Academic Publishers.

2002

  • Wadhwa, R., Sugihara, T., Hasan, M., Taira, K., Reddel, R., Kaul, S. (2002). A Major Functional Difference between the mouse and Human ARF Tumor Suppressor proteins. Journal of Biological Chemistry, 277(39), 36665-36670.
  • Henson, J., Neumann, A., Yeager, T., Reddel, R. (2002). Alternative lengthening of telomeres in mammalian cells. Oncogene, 21(4), 598-610.
  • Toouli, C., Huschtscha, L., Neumann, A., Noble, J., Colgin, L., Hukku, B., Reddel, R. (2002). Comparison of human mammary epithelial cells immortalized by simian virus 40 T-antigen or by the telomerase catalytic subunit. Oncogene, 21(1), 128-139.
  • Wadhwa, R., Yaguchi, T., Hasan, M., Mitsui, Y., Reddel, R., Kaul, S. (2002). Hsp70 Family Member, mot-2/mthsp70/GRP75, binds to the Cytoplasmic Sequestration Domain of the P53 Gene. Experimental Cell Research, 274(2), 246-253. [More Information]
  • Varley, H., Pickett, H., Foxon, J., Reddel, R., Royle, N. (2002). Molecular characterisation of inter-telomere and intra-telomere mutations in human ALT cells. Nature Genetics, 30(3), 301-305.
  • Wadhwa, R., Colgin, L., Yaguchi, T., Taira, K., Reddel, R., Kaul, S. (2002). Rhodacyanine Dye MKT-077 Inhibits in Vito Telomerase Assay but has no detectable effects on Telomerase activity in vivo. Cancer Research, 62(15), 4434-4438.
  • Bouras, T., Southey, M., Chang, A., Reddel, R., Willhite, D., Glynne, R., Henderson, M., Armes, J., Venter, D. (2002). Stanniocalcin 2 is an estorgen-responsive gene coexpressed with the estrogen receptor in human breast cancer. Cancer Research, 62(5), 1289-1295.
  • Neumann, A., Reddel, R. (2002). Telomere maintenance and cancer - look, no Telomerase. Nature Reviews Cancer, 2(11), 879-884.
  • Fasching, C., Reddel, R. (2002). Telomere maintenance in human cell lines and tumors without telomerase. In Guido Krupp and Reza Parwaresch (Eds.), Telomeres and telomerases: Cancer and Biology, (pp. 359-373). Georgetown, Texas, USA: Landes Biosciences.

2001

  • Reddel, R., Bryan, T., Colgin, L., Perrem, K., Yeager, T. (2001). Alternative lengthening of telomeres in human cells. Radiation Research, 155(1), 194-200. [More Information]
  • Reddel, R. (2001). An alternative lifestyle for immortalized oral keratinocytes. Journal of Clinical Investigation, 108, 665-667.
  • Reddel, R., Kaul, S., Mitsui,, Y., Wadhwa, R. (2001). An N-Terminal Region of Mot-2 Binds to p53 In Vitro. Neoplasia (Spanish Edition): oncologia multidisciplinaria, 3, 110-114.
  • Perrem, K., Colgin, L., Neumann,, A., Yeager, T., Reddel, R. (2001). Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells. Molecular and Cellular Biology, 21, 3862-3875.
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