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Professor Roger Truscott

Honorary Professor
Clinical Ophthalmology & Eye Health, Central Clinical School

Telephone +61 2 4221 3503
Fax +61 2 4221 4287

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Keywords

Proteomics; Ageing; Vision

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Clinical Specialty

Ophthalmology

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International links

New Zealand

(Auckland University) A collaboration with Professor Paul Donaldson to examine lens structure and function.

United States

(Oregon Health Sciences University) A program to examine the molecular changes associated with protein aging in the lens in collaboration with Professor Larry David.

United States

(Vanderbilt University) An NIH-funded collaboration with Professor Kevin Schey to elucidate molecular changes associated with human aging and cataract formation.Techniques involve itraq and MALDI imaging.

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Selected grants

2012

  • Multiplexed capabilities for surface analysis and imaging by mass spectrometry; Blanksby S, Davies M, Truscott R; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Integrated Facility for Confocal Imaging and Single Molecule Fluorescence Analysis; Yerbury J, Olsson M, Sunde M, Campbell I, Truscott R; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2011

  • Bio-Rad CFX384 Real-Time PCR Detection System; McAvoy J, Truscott R, Gillies M, Lovicu F, Martin P, Grunert U; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Ancient proteins and disease.; Truscott R, Mitchell T; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Unique, state-of-the-art lipidomics infrastructure; Mitchell T, Truscott R, Storlien L, Caterson I; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2008

  • Characterising protein and membrane changes in age-related cataract lenses; Truscott R, Guilhaus M; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • The molecular basis of age-related nuclear cataract; Truscott R; University of Sydney/Bridging Support.

2006

  • Understanding lens aging: the molecular basis of presbyopia; Truscott R, McAvoy J, Aquilina J, Aquilina J; Australian Research Council (ARC)/Discovery Projects (DP).
  • Presbyopia:why we all need reading glasses by age 50. Is it a precursor of cataract?; Truscott R; University of Sydney/Research & Development.
  • Rebecca Cooper Medical Research Foundation - Research Grants Program; Truscott R; Rebecca Cooper Medical Research Foundation/Rebecca Cooper Medical Research Foundation.
  • Nuclear Cataract: Role Of UV Filters And The Lens Barrier; Truscott R; National Institutes of Health/Research Grants.
  • Elucidating the molecular basis of presbyopia and examining the link between presbyopia and age-related nuclear cataract; Truscott R; Ophthalmic Research Institute of Australia (ORIA)/Research Grants in Ophthalmology.

2005

  • Srfb; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

2004

  • The molecular processes involved in age-related human nuclear cataract; Truscott R, Davies M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Inverted flourescence microscope workstation, including:; McAvoy J, Lovicu F, Truscott R, Madigan M, Provis J, Gillies M, McClellan K; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • Studies on age related changes in the human lens; Truscott R; Sydney Eye Hospital Foundation/Research Grant.
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Selected publications

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Book Chapters

  • Truscott, R. (2007). Eye Lens Proteins and Cataracts. In Vladimir N Uversky and Anthony L Fink (Eds.), Protein Misfolding, Aggregation, and Conformational Diseases, (pp. 435-450). USA: Springer.

Journals

  • Hooi, M., Raftery, M., Truscott, R. (2012). Age-dependent deamidation of glutamine residues in human yS crystallin: Deamidation and unstructured regions. Protein Science, 21(7), 1074-1079. [More Information]
  • Friedrich, M., Lam, J., Truscott, R. (2012). Degradation of an Old Human Protein: Age-Dependent Cleavage of γS-Crystallin Generates a Peptide that Binds to Cell Membranes. Journal of Biological Chemistry, 287(46), 39012-39020. [More Information]
  • Hughes, J., Deeley, J., Blanksby, S., Leisch, F., Ellis, S., Truscott, R., Mitchell, T. (2012). Instability of the cellular lipidome with age. Age, 34(4), 935-947. [More Information]
  • Truscott, R., Mizdrak, J., Friedrich, M., Hooi, M., Lyons, B., Jamie, J., Davies, M., Wilmarth, P., David, L. (2012). Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine? Experimental Eye Research, 99(1), 48-54. [More Information]
  • Su, S., Lyons, B., Friedrich, M., McArthur, J., Song, X., Xavier, D., Truscott, R., Aquilina, J. (2012). Molecular signatures of long-lived proteins: autolytic cleavage adjacent to serine residues. Aging Cell, 11(6), 1125-1127. [More Information]
  • Hooi, M., Raftery, M., Truscott, R. (2012). Racemization of Two Proteins over Our Lifespan: Deamidation of Asparagine 76 in yS Crystallin Is Greater in Cataract than in Normal Lenses across the Age Range. Investigative Ophthalmology and Visual Science, 53(7), 3554-3561. [More Information]
  • Nealon, J., Blanksby, S., Donaldson, P., Truscott, R., Mitchell, T. (2011). Fatty Acid Uptake and Incorporation into Phospholipids in the Rat Lens. Investigative Ophthalmology and Visual Science, 52(2), 804-809. [More Information]
  • Truscott, R. (2011). Macromolecular deterioration as the ultimate constraint on human lifespan. Ageing Research Reviews, 10(4), 397-403. [More Information]
  • Hooi, M., Truscott, R. (2011). Racemisation and human cataract. D-Ser, D-Asp/Asn and d-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses. Age, 33(2), 131-141. [More Information]
  • Lyons, B., Jamie, J., Truscott, R. (2011). Spontaneous cleavage of proteins at serine residues. International Journal of Peptide Research and Therapeutics, 17(2), 131-135. [More Information]
  • Su, S., McArthur, J., Truscott, R., Aquilina, J. (2011). Truncation, cross-linking and interaction of crystallins and intermediate filament proteins in the aging human lens. Biochimica et Biophysica Acta. Proteins and Proteomics, 1814 (5), 647-656. [More Information]
  • Su, S., McArthur, J., Friedrich, M., Truscott, R., Aquilina, J. (2011). Understanding the α-crystallin cell membrane conjunction. Molecular Vision, 17, 2798-2807.
  • Hains, P., Truscott, R. (2010). Age-Dependant Deamidation of Life-Long Proteins in the Human Lens. Investigative Ophthalmology and Visual Science, 51(6), 3107-3114. [More Information]
  • Zhu, X., Korlimbinis, A., Truscott, R. (2010). Age-Dependent Denaturation of Enzymes in the Human Lens: A Paradigm for Organismic Aging? Rejuvenation Research, 13(5), 553-560. [More Information]
  • Zhu, X., Gaus, K., Lu, Y., Magenau, A., Truscott, R., Mitchell, T. (2010). alpha- and beta-Crystallins Modulate the Head Group Order of Human Lens Membranes during Aging. Investigative Ophthalmology and Visual Science, 51(10), 5162-5167. [More Information]
  • Truscott, R. (2010). Are Ancient Proteins Responsible for the Age-Related Decline in Health and Fitness? Rejuvenation Research, 13(1), 83-89. [More Information]
  • Ellis, S., Wu, C., Deeley, J., Zhu, X., Truscott, R., Panhuis, M., Cooks, R., Mitchell, T., Blanksby, S. (2010). Imaging of Human Lens Lipids by Desorption Electrospray Ionization Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 21(12), 2095-2104. [More Information]
  • Friedrich, M., Truscott, R. (2010). Large scale binding of {alpha}-crystallin to cell membranes of aged normal human lenses; a phenomenon that can be induced by mild thermal stress. Investigative Ophthalmology and Visual Science, 51(10), 5145-5152. [More Information]
  • Truscott, R., Zhu, X. (2010). Presbyopia and Cataract: A question of Heat and Time. Progress in Retinal and Eye Research, 29(6), 487-499. [More Information]
  • Hooi, M., Truscott, R. (2010). Racemisation and human cataract. D: -Ser, D: -Asp/Asn and D: -Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses. Age, 33(2), 131-141. [More Information]
  • Deeley, J., Hankin, J., Friedrich, M., Murphy, R., Truscott, R., Mitchell, T., Blanksby, S. (2010). Sphingolipid distribution changes with age in the human lens. Journal of Lipid Research, 51, 2753-2760. [More Information]
  • Truscott, R., Comte-Walters, S., Ablonczy, Z., Schwacke, J., Berry, Y., Korlimbinis, A., Friedrich, M., Schey, K. (2010). Tight Binding of Proteins to Membranes From Older Human Cells. Age, , 1-12. [More Information]
  • Deeley, J., Thomas, M., Truscott, R., Mitchell, T., Blanksby, S. (2009). Identification of Abundant Alkyl Ether Glycerophospholipids in the Human Lens by Tandem Mass Spectrometry Techniques. Analytical Chemistry, 81(5), 1920-1930. [More Information]
  • Friedrich, M., Truscott, R. (2009). Membrane association of proteins in the aging human lens: profound changes take place in the 5th decade of life. Investigative Ophthalmology and Visual Science, 50(10), 4786-4793. [More Information]
  • Korlimbinis, A., Berry, Y., Thibault, D., Schey, K., Truscott, R. (2009). Protein aging: Truncation of aquaporin 0 in human lens regions is a continuous age-dependent process. Experimental Eye Research, 88, 966-973. [More Information]
  • Heys, K., Friedrich, M., Truscott, R. (2008). Free and bound water in normal and cataractous human lenses. Investigative Ophthalmology and Visual Science, 49(5), 1991-1997. [More Information]
  • Deeley, J., Mitchell, T., Wei, X., Korth, J., Nealon, J., Blanksby, S., Truscott, R. (2008). Human lens lipids differ markedly from those of commonly used experimental animals. Biochimica et Biophysica Acta, 1781 (6-7), 288-298. [More Information]
  • Truscott, R. (2008). Presbyopia. Emerging from a blur towards an understanding of the molecular basis for this most common eye condition. Experimental Eye Research, 88, 241-7. [More Information]
  • Hains, P., Truscott, R. (2008). Proteome analysis of human foetal, aged and advanced nuclear cataract lenses. Proteomics - Clinical Applications, 2(12), 1611-1619. [More Information]
  • Truscott, R., Hains, P. (2008). Proteomic analysis of the oxidation of cysteine residues in human age-related nuclear cataract lenses. Biochimica et Biophysica Acta, 1784, 1959-1964. [More Information]
  • Heys, K., Truscott, R. (2008). The stiffness of human cataract lenses is a function of both age and the type of cataract. Experimental Eye Research, 86(4), 701-703. [More Information]
  • Mizdrak, J., Hains, P., Kalinowski, D., Truscott, R., Davies, M., Jamie, J. (2007). Novel human lens metabolites from normal and cataractous human lenses. Tetrahedron, 63(23), 4990-4999. [More Information]
  • Hains, P., Truscott, R. (2007). Post-Translational Modifications in the Nuclear Region of Young, Aged, and Cataract Human Lenses. Journal of Proteome Research, 6(10), 3935-3943. [More Information]
  • Heys, K., Friedrich, M., Truscott, R. (2007). Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, alpha-crystallin, in maintaining lens flexibility. Aging Cell, 6(6), 807-815. [More Information]
  • Korlimbinis, A., Aquilina, J., Truscott, R. (2007). Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses. Experimental Eye Research, 85(2), 219-225. [More Information]
  • Korlimbinis, A., Aquilina, J., Truscott, R. (2007). Protein-bound UV filters in normal human lenses: the concentration of bound UV filters equals that of free UV filters in the center of older lenses. Investigative Ophthalmology and Visual Science, 48(4), 1718-1723. [More Information]
  • Parker, N., Korlimbinis, A., Jamie, J., Davies, M., Truscott, R. (2007). Reversible binding of kynurenine to lens proteins: potential protection by glutathione in young lenses. Investigative Ophthalmology and Visual Science, 48(8), 3705-3713. [More Information]
  • Mizdrak, J., Hains, P., Truscott, R., Jamie, J., Davies, M. (2007). Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage. Free Radical Biology and Medicine, 44(6), 1108-1119. [More Information]
  • Korlimbinis, A., Hains, P., Truscott, R., Aquilina, J. (2006). 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis. Biochemistry, 45(6), 1852-1860. [More Information]
  • Matin, A., Streete, I., Jamie, I., Truscott, R., Jamie, J. (2006). A fluorescence-based assay for indoleamine 2,3-dioxygenase. Analytical Biochemistry, 349(1), 96-102. [More Information]
  • Korlimbinis, A., Truscott, R. (2006). Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. Biochemistry, 45(6), 1950-1960. [More Information]
  • Hains, P., Mizdrak, J., Streete, I., Jamie, J., Truscott, R. (2006). Identification of the new UV filter compound cysteine-l-3-hydroxykynurenine O-beta-d-glucoside in human lenses. FEBS Letters, 580(21), 5071-5076. [More Information]
  • McGinty, S., Truscott, R. (2006). Presbyopia: the first stage of nuclear cataract? Ophthalmic research, 38(3), 137-148. [More Information]
  • Hains, P., Simpanya, M., Giblin, F., Truscott, R. (2006). UV filters in the lens of the thirteen lined ground squirrel (Spermophilus tridecemlineatus). Experimental Eye Research, 82(4), 730-737. [More Information]
  • Truscott, R. (2005). Age-related nuclear cataract-oxidation is the key. Experimental Eye Research, 80(5), 709-725. [More Information]
  • Ferry, G., Ubeaud, C., Lambert, P., Bertin, S., Coge, F., Chomarat, P., Delagrange, P., Serkiz, B., Bouchet, J., Truscott, R., et al (2005). Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. Biochemical Journal, 388(Part 1), 205. [More Information]
  • Heys, K., Cram, S., Truscott, R. (2004). Massive Increase In The Stiffness Of The Human Lens Nucleus With Age: The Basis For Presbyopia? Molecular Vision, 10(114), 956-963.
  • Vazquez, S., Parker, N., Sheil, M., Truscott, R. (2004). Protein-Bound Kynurenine Decreases With The Progression Of Age-Related Nuclear Cataract. Investigative Ophthalmology and Visual Science, 45(3), 879-883. [More Information]
  • Parker, N., Jamie, J., Davies, M., Truscott, R. (2004). Protein-Bound Kynurenine Is A Photosensitizer Of Oxidative Damage. Free Radical Biology and Medicine, 37(9), 1479-1489. [More Information]
  • McNulty, R., Wang, H., Mathias, R., Ortwerth, B., Truscott, R., Bassnett, S. (2004). Regulation Of Tissue Oxygen Levels In The Mammalian Lens. The Journal of Physiology, 559(3), 883-898.
  • Sweeney, M., Garland, D., Truscott, R. (2003). Movement of cysteine in intact monkey lenses: the major site of entry is the germinative region. Experimental Eye Research, 77(2), 245-251. [More Information]
  • Hains, P., Gao, L., Truscott, R. (2003). The photosensitiser xanthurenic acid is not present in normal human lenses. Experimental Eye Research, 77(5), 547-553. [More Information]
  • Hazell, L., Fu, H., Dean, R., Stocker, R., Truscott, R. (2002). Is hypochlorous acid (HOCI) involved in age-related nuclear cataract? Clinical and Experimental Optometry, 85(2), 97-100.
  • Terentis, A., Thomas, S., Takikawa, O., Littlejohn, T., Truscott, R., Armstrong, R., Yeh, S., Stocker, R. (2002). The Heme Environment of Recombinant Human Indoleamine 2,3-Dioxygenase: Structural Properties and Substrate-Ligand Interactions. Journal of Biological Chemistry, 277(18), 15788-15794. [More Information]

2012

  • Hooi, M., Raftery, M., Truscott, R. (2012). Age-dependent deamidation of glutamine residues in human yS crystallin: Deamidation and unstructured regions. Protein Science, 21(7), 1074-1079. [More Information]
  • Friedrich, M., Lam, J., Truscott, R. (2012). Degradation of an Old Human Protein: Age-Dependent Cleavage of γS-Crystallin Generates a Peptide that Binds to Cell Membranes. Journal of Biological Chemistry, 287(46), 39012-39020. [More Information]
  • Hughes, J., Deeley, J., Blanksby, S., Leisch, F., Ellis, S., Truscott, R., Mitchell, T. (2012). Instability of the cellular lipidome with age. Age, 34(4), 935-947. [More Information]
  • Truscott, R., Mizdrak, J., Friedrich, M., Hooi, M., Lyons, B., Jamie, J., Davies, M., Wilmarth, P., David, L. (2012). Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine? Experimental Eye Research, 99(1), 48-54. [More Information]
  • Su, S., Lyons, B., Friedrich, M., McArthur, J., Song, X., Xavier, D., Truscott, R., Aquilina, J. (2012). Molecular signatures of long-lived proteins: autolytic cleavage adjacent to serine residues. Aging Cell, 11(6), 1125-1127. [More Information]
  • Hooi, M., Raftery, M., Truscott, R. (2012). Racemization of Two Proteins over Our Lifespan: Deamidation of Asparagine 76 in yS Crystallin Is Greater in Cataract than in Normal Lenses across the Age Range. Investigative Ophthalmology and Visual Science, 53(7), 3554-3561. [More Information]

2011

  • Nealon, J., Blanksby, S., Donaldson, P., Truscott, R., Mitchell, T. (2011). Fatty Acid Uptake and Incorporation into Phospholipids in the Rat Lens. Investigative Ophthalmology and Visual Science, 52(2), 804-809. [More Information]
  • Truscott, R. (2011). Macromolecular deterioration as the ultimate constraint on human lifespan. Ageing Research Reviews, 10(4), 397-403. [More Information]
  • Hooi, M., Truscott, R. (2011). Racemisation and human cataract. D-Ser, D-Asp/Asn and d-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses. Age, 33(2), 131-141. [More Information]
  • Lyons, B., Jamie, J., Truscott, R. (2011). Spontaneous cleavage of proteins at serine residues. International Journal of Peptide Research and Therapeutics, 17(2), 131-135. [More Information]
  • Su, S., McArthur, J., Truscott, R., Aquilina, J. (2011). Truncation, cross-linking and interaction of crystallins and intermediate filament proteins in the aging human lens. Biochimica et Biophysica Acta. Proteins and Proteomics, 1814 (5), 647-656. [More Information]
  • Su, S., McArthur, J., Friedrich, M., Truscott, R., Aquilina, J. (2011). Understanding the α-crystallin cell membrane conjunction. Molecular Vision, 17, 2798-2807.

2010

  • Hains, P., Truscott, R. (2010). Age-Dependant Deamidation of Life-Long Proteins in the Human Lens. Investigative Ophthalmology and Visual Science, 51(6), 3107-3114. [More Information]
  • Zhu, X., Korlimbinis, A., Truscott, R. (2010). Age-Dependent Denaturation of Enzymes in the Human Lens: A Paradigm for Organismic Aging? Rejuvenation Research, 13(5), 553-560. [More Information]
  • Zhu, X., Gaus, K., Lu, Y., Magenau, A., Truscott, R., Mitchell, T. (2010). alpha- and beta-Crystallins Modulate the Head Group Order of Human Lens Membranes during Aging. Investigative Ophthalmology and Visual Science, 51(10), 5162-5167. [More Information]
  • Truscott, R. (2010). Are Ancient Proteins Responsible for the Age-Related Decline in Health and Fitness? Rejuvenation Research, 13(1), 83-89. [More Information]
  • Ellis, S., Wu, C., Deeley, J., Zhu, X., Truscott, R., Panhuis, M., Cooks, R., Mitchell, T., Blanksby, S. (2010). Imaging of Human Lens Lipids by Desorption Electrospray Ionization Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 21(12), 2095-2104. [More Information]
  • Friedrich, M., Truscott, R. (2010). Large scale binding of {alpha}-crystallin to cell membranes of aged normal human lenses; a phenomenon that can be induced by mild thermal stress. Investigative Ophthalmology and Visual Science, 51(10), 5145-5152. [More Information]
  • Truscott, R., Zhu, X. (2010). Presbyopia and Cataract: A question of Heat and Time. Progress in Retinal and Eye Research, 29(6), 487-499. [More Information]
  • Hooi, M., Truscott, R. (2010). Racemisation and human cataract. D: -Ser, D: -Asp/Asn and D: -Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses. Age, 33(2), 131-141. [More Information]
  • Deeley, J., Hankin, J., Friedrich, M., Murphy, R., Truscott, R., Mitchell, T., Blanksby, S. (2010). Sphingolipid distribution changes with age in the human lens. Journal of Lipid Research, 51, 2753-2760. [More Information]
  • Truscott, R., Comte-Walters, S., Ablonczy, Z., Schwacke, J., Berry, Y., Korlimbinis, A., Friedrich, M., Schey, K. (2010). Tight Binding of Proteins to Membranes From Older Human Cells. Age, , 1-12. [More Information]

2009

  • Deeley, J., Thomas, M., Truscott, R., Mitchell, T., Blanksby, S. (2009). Identification of Abundant Alkyl Ether Glycerophospholipids in the Human Lens by Tandem Mass Spectrometry Techniques. Analytical Chemistry, 81(5), 1920-1930. [More Information]
  • Friedrich, M., Truscott, R. (2009). Membrane association of proteins in the aging human lens: profound changes take place in the 5th decade of life. Investigative Ophthalmology and Visual Science, 50(10), 4786-4793. [More Information]
  • Korlimbinis, A., Berry, Y., Thibault, D., Schey, K., Truscott, R. (2009). Protein aging: Truncation of aquaporin 0 in human lens regions is a continuous age-dependent process. Experimental Eye Research, 88, 966-973. [More Information]

2008

  • Heys, K., Friedrich, M., Truscott, R. (2008). Free and bound water in normal and cataractous human lenses. Investigative Ophthalmology and Visual Science, 49(5), 1991-1997. [More Information]
  • Deeley, J., Mitchell, T., Wei, X., Korth, J., Nealon, J., Blanksby, S., Truscott, R. (2008). Human lens lipids differ markedly from those of commonly used experimental animals. Biochimica et Biophysica Acta, 1781 (6-7), 288-298. [More Information]
  • Truscott, R. (2008). Presbyopia. Emerging from a blur towards an understanding of the molecular basis for this most common eye condition. Experimental Eye Research, 88, 241-7. [More Information]
  • Hains, P., Truscott, R. (2008). Proteome analysis of human foetal, aged and advanced nuclear cataract lenses. Proteomics - Clinical Applications, 2(12), 1611-1619. [More Information]
  • Truscott, R., Hains, P. (2008). Proteomic analysis of the oxidation of cysteine residues in human age-related nuclear cataract lenses. Biochimica et Biophysica Acta, 1784, 1959-1964. [More Information]
  • Heys, K., Truscott, R. (2008). The stiffness of human cataract lenses is a function of both age and the type of cataract. Experimental Eye Research, 86(4), 701-703. [More Information]

2007

  • Truscott, R. (2007). Eye Lens Proteins and Cataracts. In Vladimir N Uversky and Anthony L Fink (Eds.), Protein Misfolding, Aggregation, and Conformational Diseases, (pp. 435-450). USA: Springer.
  • Mizdrak, J., Hains, P., Kalinowski, D., Truscott, R., Davies, M., Jamie, J. (2007). Novel human lens metabolites from normal and cataractous human lenses. Tetrahedron, 63(23), 4990-4999. [More Information]
  • Hains, P., Truscott, R. (2007). Post-Translational Modifications in the Nuclear Region of Young, Aged, and Cataract Human Lenses. Journal of Proteome Research, 6(10), 3935-3943. [More Information]
  • Heys, K., Friedrich, M., Truscott, R. (2007). Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, alpha-crystallin, in maintaining lens flexibility. Aging Cell, 6(6), 807-815. [More Information]
  • Korlimbinis, A., Aquilina, J., Truscott, R. (2007). Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses. Experimental Eye Research, 85(2), 219-225. [More Information]
  • Korlimbinis, A., Aquilina, J., Truscott, R. (2007). Protein-bound UV filters in normal human lenses: the concentration of bound UV filters equals that of free UV filters in the center of older lenses. Investigative Ophthalmology and Visual Science, 48(4), 1718-1723. [More Information]
  • Parker, N., Korlimbinis, A., Jamie, J., Davies, M., Truscott, R. (2007). Reversible binding of kynurenine to lens proteins: potential protection by glutathione in young lenses. Investigative Ophthalmology and Visual Science, 48(8), 3705-3713. [More Information]
  • Mizdrak, J., Hains, P., Truscott, R., Jamie, J., Davies, M. (2007). Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage. Free Radical Biology and Medicine, 44(6), 1108-1119. [More Information]

2006

  • Korlimbinis, A., Hains, P., Truscott, R., Aquilina, J. (2006). 3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis. Biochemistry, 45(6), 1852-1860. [More Information]
  • Matin, A., Streete, I., Jamie, I., Truscott, R., Jamie, J. (2006). A fluorescence-based assay for indoleamine 2,3-dioxygenase. Analytical Biochemistry, 349(1), 96-102. [More Information]
  • Korlimbinis, A., Truscott, R. (2006). Identification of 3-hydroxykynurenine bound to proteins in the human lens. A possible role in age-related nuclear cataract. Biochemistry, 45(6), 1950-1960. [More Information]
  • Hains, P., Mizdrak, J., Streete, I., Jamie, J., Truscott, R. (2006). Identification of the new UV filter compound cysteine-l-3-hydroxykynurenine O-beta-d-glucoside in human lenses. FEBS Letters, 580(21), 5071-5076. [More Information]
  • McGinty, S., Truscott, R. (2006). Presbyopia: the first stage of nuclear cataract? Ophthalmic research, 38(3), 137-148. [More Information]
  • Hains, P., Simpanya, M., Giblin, F., Truscott, R. (2006). UV filters in the lens of the thirteen lined ground squirrel (Spermophilus tridecemlineatus). Experimental Eye Research, 82(4), 730-737. [More Information]

2005

  • Truscott, R. (2005). Age-related nuclear cataract-oxidation is the key. Experimental Eye Research, 80(5), 709-725. [More Information]
  • Ferry, G., Ubeaud, C., Lambert, P., Bertin, S., Coge, F., Chomarat, P., Delagrange, P., Serkiz, B., Bouchet, J., Truscott, R., et al (2005). Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. Biochemical Journal, 388(Part 1), 205. [More Information]

2004

  • Heys, K., Cram, S., Truscott, R. (2004). Massive Increase In The Stiffness Of The Human Lens Nucleus With Age: The Basis For Presbyopia? Molecular Vision, 10(114), 956-963.
  • Vazquez, S., Parker, N., Sheil, M., Truscott, R. (2004). Protein-Bound Kynurenine Decreases With The Progression Of Age-Related Nuclear Cataract. Investigative Ophthalmology and Visual Science, 45(3), 879-883. [More Information]
  • Parker, N., Jamie, J., Davies, M., Truscott, R. (2004). Protein-Bound Kynurenine Is A Photosensitizer Of Oxidative Damage. Free Radical Biology and Medicine, 37(9), 1479-1489. [More Information]
  • McNulty, R., Wang, H., Mathias, R., Ortwerth, B., Truscott, R., Bassnett, S. (2004). Regulation Of Tissue Oxygen Levels In The Mammalian Lens. The Journal of Physiology, 559(3), 883-898.

2003

  • Sweeney, M., Garland, D., Truscott, R. (2003). Movement of cysteine in intact monkey lenses: the major site of entry is the germinative region. Experimental Eye Research, 77(2), 245-251. [More Information]
  • Hains, P., Gao, L., Truscott, R. (2003). The photosensitiser xanthurenic acid is not present in normal human lenses. Experimental Eye Research, 77(5), 547-553. [More Information]

2002

  • Hazell, L., Fu, H., Dean, R., Stocker, R., Truscott, R. (2002). Is hypochlorous acid (HOCI) involved in age-related nuclear cataract? Clinical and Experimental Optometry, 85(2), 97-100.
  • Terentis, A., Thomas, S., Takikawa, O., Littlejohn, T., Truscott, R., Armstrong, R., Yeh, S., Stocker, R. (2002). The Heme Environment of Recombinant Human Indoleamine 2,3-Dioxygenase: Structural Properties and Substrate-Ligand Interactions. Journal of Biological Chemistry, 277(18), 15788-15794. [More Information]
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