Dr Ronald Sluyter

Senior Research Fellow
Medicine, Nepean Clinical School

Telephone +61 2 4734 3775
Fax +61 2 4734 3432

Map

Selected grants

2007

  • FLUOstar OPTIMA Fluorescent Microplate Reader 25000; Sluyter R; Clive & Vera Ramaciotti Foundation/Clive & Vera Ramaciotti Fndtn.

2005

  • Role of P2X7 in innate and adaptive immunity to myobacterial infections; Wiley J, Saunders B, Sluyter R, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Tumour B-cells from lymphomas are resistant to ATP-mediated apoptosis due to non-functional P2X7 receptors; Wiley J, Barden J, Sluyter R; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Britton, W., Fernando, S., Saunders, B., Sluyter, R., Wiley, J. (2007). The genetic control of susceptibility to Mycobacterium tuberculosis. In Gregory Bock(Organizer) and Jamie Goode (Eds.), Decoding the Genomic Control of Immune Reactions, (pp. 79-92). United Kingdom: John Wiley & Sons. [More Information]

Journals

  • Tran, J., Pupovac, A., Taylor, R., Wiley, J., Byrne, S., Sluyter, R. (2010). Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors. Experimental Dermatology, 19(8), e151-e157. [More Information]
  • Gadeock, S., Tran, J., Georgiou, J., Jalilian, I., Taylor, R., Wiley, J., Sluyter, R. (2010). TGF-B1 prevents up-regulation of the P2X7 receptor by IFN-y and LPS in leukemic THP-1 monocytes. Biochimica et Biophysica Acta-Biomembranes, 1798 (11), 2058-2066. [More Information]
  • Stokes, L., Fuller, S., Sluyter, R., Skarratt, K., Gu, B., Wiley, J. (2010). Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1{beta} secretion. The F A S E B Journal, 24(8), 2916-2927. [More Information]
  • Eslick, G., Thampan, B., Nalos, M., McLean, A., Sluyter, R. (2009). Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure. International Journal of Cardiology, 137(1), 81-83. [More Information]
  • Stevenson, R., Taylor, R., Wiley, J., Sluyter, R. (2009). The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types. Purinergic Signalling, 5(3), 385-394. [More Information]
  • Nalos, M., Huang, S., Sluyter, R., Khan, A., Nanan, B., Nanan, R., McLean, A. (2008). Host tissue damage signal ATP impairs IL-12 and IFN {gamma} secretion in LPS stimulated whole human blood. Intensive Care Medicine, 34(10), 1891-1897. [More Information]
  • Jursik, C., Sluyter, R., Georgiou, J., Fuller, S., Wiley, J., Gu, B. (2007). A quantitative method for routine measurement of cell surface P2X(7) receptor function in leucocyte subsets by two-colour time-resolved flow cytometry. Journal of Immunological Methods, 325(1-2), 67-77. [More Information]
  • Sluyter, R., Shemon, A., Hughes, W., Stevenson, R., Georgiou, J., Eslick, G., Taylor, R., Wiley, J. (2007). Canine erythrocytes express the P2X7 receptor: greatly increased function compared to human erythrocytes. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (Print), 293(5), R2090-R2098. [More Information]
  • Shemon, A., Sluyter, R., Stokes, L., Manley, P., Wiley, J. (2007). Inhibition of the human P2X7 receptor by a novel protein tyrosine kinase antagonist. Biochemical and Biophysical Research Communications, 365(Available online 20 November 2007), 515-520. [More Information]
  • Sluyter, R., Shemon, A., Wiley, J. (2007). P2X(7) receptor activation causes phosphatidylserine exposure in human erythrocytes. Biochemical and Biophysical Research Communications, 355(1), 169-173. [More Information]
  • Fernando, S., Saunders, B., Sluyter, R., Skarratt, K., Goldburg, H., Marks, G., Wiley, J., Britton, W. (2006). A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis. American Journal of Respiratory and Critical Care Medicine, 175(4), 360-366. [More Information]
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2006). A Thr(357) to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X(7) function and impairs ATP-induced mycobacterial killing by macrophages. Journal of Biological Chemistry, 281(4), 2079-2086. [More Information]
  • Shemon, A., Sluyter, R., Wiley, J. (2006). Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes. Immunology and Cell Biology, 85(1), 68-72. [More Information]
  • Skarratt, K., Fuller, S., Sluyter, R., Dao-Ung, L., Gu, B., Wiley, J. (2005). A 50 intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1–2% of the Caucasian population. FEBS Letters, 579(12), 2675-2678. [More Information]
  • Fernando, S., Saunders, B., Sluyter, R., Skarratt, K., Wiley, J., Britton, W. (2005). Gene Dosage Determines the Negative Effects of Polymorphic Alleles of the P2X7 Receptor on Adenosine Triphosphate–Mediated Killing of Mycobacteria by Human Macrophages. The Journal of Infectious Diseases, 192(1), 149-155. [More Information]
  • Georgiou, J., Skarratt, K., Fuller, S., Martin, C., Christopherson, R., Wiley, J., Sluyter, R. (2005). Human Epidermal and Monocyte-Derived Langerhans Cells Express Functional P2X7 Receptors. The Journal of Investigative Dermatology, 125(3), 482-490. [More Information]
  • Shemon, A., Sluyter, R., Wiley, J. (2005). Novel protein kinase C Isoforms mediate both extracellular ATP and PMA-induced phospholipase D activity in B-lymphocytes. Tissue Antigens: immune response genetics, 66(5), 541-541.
  • Tanneur, V., Duranton, C., Brand, V., Sandu, C., Akkaya, C., Kasinathan, R., Gachet, C., Sluyter, R., Barden, J., Wiley, J., et al (2005). Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes. The F A S E B Journal, online, 1-27. [More Information]
  • Gu, B., Sluyter, R., Skarratt, K., Shemon, A., Dao-Ung, L., Fuller, S., Barden, J., Clarke, A., Petrou, S., Wiley, J. (2004). An Arg307 To Gln Polymorphism Within The Atp-Binding Site Causes Loss Of Function Of The Human P2X7 Receptor. Journal of Biological Chemistry, 279(30), 31287-31295.
  • Dao-Ung, L., Fuller, S., Sluyter, R., Skarratt, K., Thunberg, U., Tobin, G., Byth Wilson, K., Ban, M., Rosenquist, R., Stewart, G., Wiley, J. (2004). Association of the 1513C polymorphism in the P2X7 gene with familial forms of chronic lymphocytic leukaemia. British Journal of Haematology, 125(6), 815-817.
  • Shemon, A., Sluyter, R., Conigrave, A., Wiley, J. (2004). Chelerythrine And Other Benzophenanthridine Alkaloids Block The Human P2X(7) Receptor. British Journal of Pharmacology, 142(6), 1015-1019.
  • Dao-Ung, L., Sluyter, R., Fuller, S., Taper, J., Wiley, J. (2004). CXCR4 but not CXCR3 expression correlates with lymphocyte counts in B-cell chronic lymphocytic leukemia. Annals of Hematology, 83(5), 326-327. [More Information]
  • Sluyter, R., Shemon, A., Barden, J., Wiley, J. (2004). Extracellular ATP Increases Cation Fluxes In Human Erythrocytes By Activation Of The P2X7 Receptor. Journal of Biological Chemistry, 279(43), 44749-44755.
  • Sluyter, R., Shemon, A., Wiley, J. (2004). Glu496 To Ala Polymorphism In The P2X7 Receptor Impairs ATP-Induced IL-1 Beta Release From Human Monocytes. Journal of Immunology, 172(6), 3399-3405.
  • Sluyter, R., Dalitz, J., Wiley, J. (2004). P2X7 Receptor Polymorphism Impairs Extracellular Adenosine 5'-Triphosphate-Induced Interleukin-18 Release From Human Monocytes. Genes and Immunity, 5(7), 588-591.
  • Saunders, B., Fernando, S., Sluyter, R., Britton, W., Wiley, J. (2003). A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of Mycobacteria. Journal of Immunology, 171(10), 5442-5446.
  • Wiley, J., Dao-Ung, L., Li, C., Shemon, A., Gu, B., Smart, M., Fuller, S., Barden, J., Petrou, S., Sluyter, R. (2003). An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. Journal of Biological Chemistry, 278(19), 17108-17113.
  • Barden, J., Sluyter, R., Gu, B., Wiley, J. (2003). Specific detection of non-functional human P2X7 receptors in HEK293 cells and B-lymphocytes. FEBS Letters, 538(1-3), 159-162.
  • Wiley, J., Dao-Ung, L., Gu, B., Sluyter, R., Shemon, A., Li, C., Taper, J., Gallo, J., Manoharan, A. (2002). A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. The Lancet, 359(9312), 1114-1119.
  • Sluyter, R., Wiley, J. (2002). Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors. International Immunology, 14(12), 1415-1421.
  • Gu, B., Zhang, W., Worthington, R., Sluyter, R., Barden, J., Wiley, J., Dao, L., Petrou, S. (2001). A Glu-496 to ala polymorphism leads to loss of function of the human P2Z7 receptor. Journal of Biological Chemistry, 276, 11135-11142.
  • Sluyter, R., Barden, J., Wiley, J. (2001). Detection of P2x purinergic receptors on human B lymphocytes. Cell and Tissue Research, 304 (2), 231-236.
  • Wiley, J., Gu, B., Zhang, W., Worthington, R., Dao, L., Shemon, A., Sluyter, R., Liang, S., Barden, J. (2001). Genetic polymorphisms of the human P2X7 receptor and rleationship to function. Drug Development Research, 53 (2-3), 72-76.

Conferences

  • Skarratt, K., Fuller, S., Sluyter, R., Dao-Ung, L., Gu, B., Wiley, J. (2005). A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Saunders, B., Fernando, S., Marks, G., Sluyter, R., Wiley, S., Britton, W. (2005). A single nucleotide polymorphism in the P2X7 gene lends susceptibility to extrapulmonary tuberculosis. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2005). A Thr(357) to ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Sluyter, R., Georgiou, J., Skarratt, K., Fuller, S., Martin, C., Christopherson, R., Wiley, J. (2005). Human epidermal and monocyte-derived langerhans cells express functional P2X7 receptors. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.

2010

  • Tran, J., Pupovac, A., Taylor, R., Wiley, J., Byrne, S., Sluyter, R. (2010). Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors. Experimental Dermatology, 19(8), e151-e157. [More Information]
  • Gadeock, S., Tran, J., Georgiou, J., Jalilian, I., Taylor, R., Wiley, J., Sluyter, R. (2010). TGF-B1 prevents up-regulation of the P2X7 receptor by IFN-y and LPS in leukemic THP-1 monocytes. Biochimica et Biophysica Acta-Biomembranes, 1798 (11), 2058-2066. [More Information]
  • Stokes, L., Fuller, S., Sluyter, R., Skarratt, K., Gu, B., Wiley, J. (2010). Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1{beta} secretion. The F A S E B Journal, 24(8), 2916-2927. [More Information]

2009

  • Eslick, G., Thampan, B., Nalos, M., McLean, A., Sluyter, R. (2009). Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure. International Journal of Cardiology, 137(1), 81-83. [More Information]
  • Stevenson, R., Taylor, R., Wiley, J., Sluyter, R. (2009). The P2X(7) receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types. Purinergic Signalling, 5(3), 385-394. [More Information]

2008

  • Nalos, M., Huang, S., Sluyter, R., Khan, A., Nanan, B., Nanan, R., McLean, A. (2008). Host tissue damage signal ATP impairs IL-12 and IFN {gamma} secretion in LPS stimulated whole human blood. Intensive Care Medicine, 34(10), 1891-1897. [More Information]

2007

  • Jursik, C., Sluyter, R., Georgiou, J., Fuller, S., Wiley, J., Gu, B. (2007). A quantitative method for routine measurement of cell surface P2X(7) receptor function in leucocyte subsets by two-colour time-resolved flow cytometry. Journal of Immunological Methods, 325(1-2), 67-77. [More Information]
  • Sluyter, R., Shemon, A., Hughes, W., Stevenson, R., Georgiou, J., Eslick, G., Taylor, R., Wiley, J. (2007). Canine erythrocytes express the P2X7 receptor: greatly increased function compared to human erythrocytes. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology (Print), 293(5), R2090-R2098. [More Information]
  • Shemon, A., Sluyter, R., Stokes, L., Manley, P., Wiley, J. (2007). Inhibition of the human P2X7 receptor by a novel protein tyrosine kinase antagonist. Biochemical and Biophysical Research Communications, 365(Available online 20 November 2007), 515-520. [More Information]
  • Sluyter, R., Shemon, A., Wiley, J. (2007). P2X(7) receptor activation causes phosphatidylserine exposure in human erythrocytes. Biochemical and Biophysical Research Communications, 355(1), 169-173. [More Information]
  • Britton, W., Fernando, S., Saunders, B., Sluyter, R., Wiley, J. (2007). The genetic control of susceptibility to Mycobacterium tuberculosis. In Gregory Bock(Organizer) and Jamie Goode (Eds.), Decoding the Genomic Control of Immune Reactions, (pp. 79-92). United Kingdom: John Wiley & Sons. [More Information]

2006

  • Fernando, S., Saunders, B., Sluyter, R., Skarratt, K., Goldburg, H., Marks, G., Wiley, J., Britton, W. (2006). A Polymorphism in the P2X7 Gene Increases Susceptibility to Extrapulmonary Tuberculosis. American Journal of Respiratory and Critical Care Medicine, 175(4), 360-366. [More Information]
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2006). A Thr(357) to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X(7) function and impairs ATP-induced mycobacterial killing by macrophages. Journal of Biological Chemistry, 281(4), 2079-2086. [More Information]
  • Shemon, A., Sluyter, R., Wiley, J. (2006). Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukaemia B-lymphocytes. Immunology and Cell Biology, 85(1), 68-72. [More Information]

2005

  • Skarratt, K., Fuller, S., Sluyter, R., Dao-Ung, L., Gu, B., Wiley, J. (2005). A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Skarratt, K., Fuller, S., Sluyter, R., Dao-Ung, L., Gu, B., Wiley, J. (2005). A 50 intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1–2% of the Caucasian population. FEBS Letters, 579(12), 2675-2678. [More Information]
  • Saunders, B., Fernando, S., Marks, G., Sluyter, R., Wiley, S., Britton, W. (2005). A single nucleotide polymorphism in the P2X7 gene lends susceptibility to extrapulmonary tuberculosis. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Shemon, A., Sluyter, R., Fernando, S., Clarke, A., Dao-Ung, L., Skarratt, K., Saunders, B., Tan, K., Gu, B., Fuller, S., Britton, W., Wiley, J., et al (2005). A Thr(357) to ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Fernando, S., Saunders, B., Sluyter, R., Skarratt, K., Wiley, J., Britton, W. (2005). Gene Dosage Determines the Negative Effects of Polymorphic Alleles of the P2X7 Receptor on Adenosine Triphosphate–Mediated Killing of Mycobacteria by Human Macrophages. The Journal of Infectious Diseases, 192(1), 149-155. [More Information]
  • Georgiou, J., Skarratt, K., Fuller, S., Martin, C., Christopherson, R., Wiley, J., Sluyter, R. (2005). Human Epidermal and Monocyte-Derived Langerhans Cells Express Functional P2X7 Receptors. The Journal of Investigative Dermatology, 125(3), 482-490. [More Information]
  • Sluyter, R., Georgiou, J., Skarratt, K., Fuller, S., Martin, C., Christopherson, R., Wiley, J. (2005). Human epidermal and monocyte-derived langerhans cells express functional P2X7 receptors. 35th Annual Scientific Meeting of the Australasian Society for Immunology 2005, Denmark: Blackwell Munksgaard.
  • Shemon, A., Sluyter, R., Wiley, J. (2005). Novel protein kinase C Isoforms mediate both extracellular ATP and PMA-induced phospholipase D activity in B-lymphocytes. Tissue Antigens: immune response genetics, 66(5), 541-541.
  • Tanneur, V., Duranton, C., Brand, V., Sandu, C., Akkaya, C., Kasinathan, R., Gachet, C., Sluyter, R., Barden, J., Wiley, J., et al (2005). Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes. The F A S E B Journal, online, 1-27. [More Information]

2004

  • Gu, B., Sluyter, R., Skarratt, K., Shemon, A., Dao-Ung, L., Fuller, S., Barden, J., Clarke, A., Petrou, S., Wiley, J. (2004). An Arg307 To Gln Polymorphism Within The Atp-Binding Site Causes Loss Of Function Of The Human P2X7 Receptor. Journal of Biological Chemistry, 279(30), 31287-31295.
  • Dao-Ung, L., Fuller, S., Sluyter, R., Skarratt, K., Thunberg, U., Tobin, G., Byth Wilson, K., Ban, M., Rosenquist, R., Stewart, G., Wiley, J. (2004). Association of the 1513C polymorphism in the P2X7 gene with familial forms of chronic lymphocytic leukaemia. British Journal of Haematology, 125(6), 815-817.
  • Shemon, A., Sluyter, R., Conigrave, A., Wiley, J. (2004). Chelerythrine And Other Benzophenanthridine Alkaloids Block The Human P2X(7) Receptor. British Journal of Pharmacology, 142(6), 1015-1019.
  • Dao-Ung, L., Sluyter, R., Fuller, S., Taper, J., Wiley, J. (2004). CXCR4 but not CXCR3 expression correlates with lymphocyte counts in B-cell chronic lymphocytic leukemia. Annals of Hematology, 83(5), 326-327. [More Information]
  • Sluyter, R., Shemon, A., Barden, J., Wiley, J. (2004). Extracellular ATP Increases Cation Fluxes In Human Erythrocytes By Activation Of The P2X7 Receptor. Journal of Biological Chemistry, 279(43), 44749-44755.
  • Sluyter, R., Shemon, A., Wiley, J. (2004). Glu496 To Ala Polymorphism In The P2X7 Receptor Impairs ATP-Induced IL-1 Beta Release From Human Monocytes. Journal of Immunology, 172(6), 3399-3405.
  • Sluyter, R., Dalitz, J., Wiley, J. (2004). P2X7 Receptor Polymorphism Impairs Extracellular Adenosine 5'-Triphosphate-Induced Interleukin-18 Release From Human Monocytes. Genes and Immunity, 5(7), 588-591.

2003

  • Saunders, B., Fernando, S., Sluyter, R., Britton, W., Wiley, J. (2003). A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of Mycobacteria. Journal of Immunology, 171(10), 5442-5446.
  • Wiley, J., Dao-Ung, L., Li, C., Shemon, A., Gu, B., Smart, M., Fuller, S., Barden, J., Petrou, S., Sluyter, R. (2003). An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. Journal of Biological Chemistry, 278(19), 17108-17113.
  • Barden, J., Sluyter, R., Gu, B., Wiley, J. (2003). Specific detection of non-functional human P2X7 receptors in HEK293 cells and B-lymphocytes. FEBS Letters, 538(1-3), 159-162.

2002

  • Wiley, J., Dao-Ung, L., Gu, B., Sluyter, R., Shemon, A., Li, C., Taper, J., Gallo, J., Manoharan, A. (2002). A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. The Lancet, 359(9312), 1114-1119.
  • Sluyter, R., Wiley, J. (2002). Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors. International Immunology, 14(12), 1415-1421.

2001

  • Gu, B., Zhang, W., Worthington, R., Sluyter, R., Barden, J., Wiley, J., Dao, L., Petrou, S. (2001). A Glu-496 to ala polymorphism leads to loss of function of the human P2Z7 receptor. Journal of Biological Chemistry, 276, 11135-11142.
  • Sluyter, R., Barden, J., Wiley, J. (2001). Detection of P2x purinergic receptors on human B lymphocytes. Cell and Tissue Research, 304 (2), 231-236.
  • Wiley, J., Gu, B., Zhang, W., Worthington, R., Dao, L., Shemon, A., Sluyter, R., Liang, S., Barden, J. (2001). Genetic polymorphisms of the human P2X7 receptor and rleationship to function. Drug Development Research, 53 (2-3), 72-76.

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