Dr Rose Cairns

BPharm (Hons I + University Medal), PhD
Lecturer, Sydney School of Pharmacy

Telephone +61 2 9351 8729
Fax +61 2 9351 4391

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Biographical details

Dr Rose Cairns is a Lecturer at the School of Pharmacy, The University of Sydney. She has a clinical role as Senior Poisons Specialist (Research and Audit) at the New South Wales Poisons Information Centre, The Children’s Hospital at Westmead. Her research interests include clinical toxicology, pharmacovigilance, toxicovigilance, severe adverse drug reactions, pharmaceutical misuse, medicines policy, and deliberate self-poisoning (self-harm overdose). Her overall goal is to reduce harm from poisoning.

Research interests

Rose’s recent research has focused on identifying trends in poisonings and analysing the effect of drug policy and scheduling. This includes work on daily dosing errors with oral methotrexate, where Rose identified increasing poisonings in recent years, including several deaths. Her work resulted in changes to the manufacturer Product Information and Consumer Medicines Information for methotrexate, and a labelling change. Rose has also examined the effect of medicine up-scheduling on drug use and misuse (recent examples include studies on codeine and alprazolam). There are several opportunities for new projects in this area using poisons centre, dispensing, hospitalisation and coronial data.

Another of Rose’s interests is Poisons Information Centre service utilisation and impact. Australian Poisons Information Centres take calls from members of the public and healthcare professionals and can thus potentially reduce unnecessary hospitalisations, improve management, optimise antidote utilisation and minimise length of stay.

Rose is interested in poisoning epidemiology, in particular she aims to uncover and assess geographical inequalities in poisoning risk and access to life-saving treatments. She aims to identify at-risk groups of paediatric poisoning and deliberate self-poisoning and identify ways to best address health system inequalities and unwarranted clinical variation. There are several opportunities for new projects in these areas which include analysis of linked data.

Associations

Editorial Board Member, TOXINZ (a clinical toxicology database used in over 20 countries)
Member, Toxicology and Poisons Network of Australasia (TAPNA)
Member, European Association of Poisons Centres and Clinical Toxicologists (EAPCCT)
Partnership Group Member, National Collaborative Network for Child Health Informatics
Member, Global Toxicosurveillance Network (GTNet), coordinated by Rocky Mountain Poisons and Drug Center, Denver, Colorado

Awards and honours

2018 Sydney Children’s Hospitals Network (SCHN) Annual Quality and Innovation Awards Winner: “Keeping People Healthy” category
2015 Best Poster Prize, Toxicology and Poisons Network of Australasia annual conference
2010 The University Medal (The University of Sydney)
2010 Pharmaceutical Society of Australia (NSW Branch) Ltd Gold Medal
2010 The University of Sydney Academic Merit Prize
2010 William Joseph Collett Shoppee Prize for Pharmaceutical Chemistry
2010 Pharmaceutical Society of Australia (NSW Branch) Ltd Prize for Proficiency in Pharmacy 4th Year
2010 Society of Hospital Pharmacists Prize for Excellence in Pharmacotherapeutics in the Bachelor of Pharmacy
2009 The University of Sydney Academic Merit Prize
2009 Pharmaceutical Society of Australia (NSW Branch) Ltd Prize for Proficiency in Pharmacy 3rd Year
2007 McGraw-Hill Australia Prize for Academic Excellence in Social Pharmacy

In the media

https://www.nps.org.au/news/new-data-act-as-a-reminder-about-accidental-poisoning-in-children
https://sydney.edu.au/medicine-health/news-and-events/2018/07/02/usyd-pharmacists--how-i-became-a-senior-poisons-specialist.html
https://theconversation.com/weekly-dose-methotrexate-the-anti-inflammatory-drug-that-can-kill-if-taken-daily-60322
https://www.smh.com.au/healthcare/worrying-rise-in-accidental-overdose-of-prescription-drug-methotrexate-20160606-gpcaz3.html
https://ajp.com.au/news/alprazolam-upschedule-cuts-overall-use-adverse-events/
http://www.abc.net.au/news/2016-06-06/methotrexate-linked-to-eight-deaths-since-2000-research-says/7479566
https://www.sbs.com.au/topics/life/health/article/2016/06/07/misuse-popular-arthritis-drug-linked-eight-deaths-2000
https://www.afr.com/lifestyle/health/methotrexate-overdosing-claims-eight-lives-20160605-gpbw6s
http://www.abc.net.au/news/2018-03-23/fact-check-over-the-counter-prescription-only-codeine/9522916
https://www.doctorportal.com.au/mjainsight/2016/21/preventable-methotrexate-errors-need-fix/
https://www.doctorportal.com.au/mjainsight/2016/46/water-beads-an-accident-waiting-to-happen/

Several radio and TV interviews discussing research on methotrexate poisoning (2GB, 2UE, Channel 7 National News)

Radio interview with National Radio News on the Australian Poisons Information Centre Annual Report

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Tebar, F., Gelabert-Baldrich, M., Hoque, M., Cairns, R., Rentero, C., Pol, A., Grewal, T., Enrich, C. (2014). Annexins and Endosomal Signaling. In John N Abelson, Melvin I. Simon, Anna Marie Pyle, Gregory L. Verdine (Eds.), Methods in Enzymology, (pp. 55-74). San Diego: Academic Press. [More Information]

Journals

  • Bell, J., Bentley, J., Downie, C., Cairns, R., Buckley, N., Katelaris, A., Pearson, S., Nassar, N. (2018). Accidental pharmacological poisonings in young children: population-based study in three settings. Clinical Toxicology, 56(8), 782-789. [More Information]
  • Peacock, A., Larance, B., Farrell, M., Cairns, R., Buckley, N., Degenhardt, L. (2018). Opioid use and harms associated with a sustained-release tapentadol formulation: a postmarketing study protocol. BMJ Open, 8(3), 1-6. [More Information]
  • Ngo, A., Cairns, R., Brown, J., Lynch, A., Robinson, J., Wylie, C., Buckley, N., Dawson, A. (2018). Patterns of poisoning exposure at different ages: the 2015 annual report of the Australian Poisons Information Centres. Medical Journal of Australia, 209(2), 74-79.
  • Balaban, S., Shearer, R., Lee, L., van Geldermalsen, M., Schreuder, M., Shtein, H., Cairns, R., Thomas, K., Fazakerley, D., Grewal, T., Holst, J., Hoy, A., et al (2017). Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer and Metabolism, 5(1). [More Information]
  • Cooper, J., Brown, J., Cairns, R., Ibister, G. (2017). Desvenlafaxine overdose and the occurrence of serotonin toxicity, seizures and cardiovascular effects. Clinical Toxicology, 55(1), 18-24. [More Information]
  • Osborne, N., Cairns, R., Dawson, A., Chitty, K., Buckley, N. (2017). Epidemiology of coronial deaths from pesticide ingestion in Australia. International Journal of Hygiene and Environmental Health, 220(2), 478-484. [More Information]
  • Cairns, R., Alvarez-Guaita, A., Mart�nez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]
  • Cairns, R., Brown, J., Gunja, N., Buckley, N. (2017). The impact of Australian legislative changes on synthetic cannabinoid exposures reported to the New South Wales Poisons Information Centre. International Journal of Drug Policy, 43, 74-82. [More Information]
  • Cairns, R., Buckley, N. (2017). The Poisoning Severity Score: If It Did Not Exist, We Would Have To Invent It. Journal of Medical Toxicology, 13(2), 131-134. [More Information]
  • Cairns, R., Brown, J., Lynch, A., Robinson, J., Wylie, C., Buckley, N. (2016). A decade of Australian methotrexate dosing errors. Medical Journal of Australia, 204(10), 384.e1-384.e6. [More Information]
  • Cairns, R., Brown, J., Buckley, N. (2016). A decade of Australian methotrexate dosing errors. Medical Journal of Australia, 205(10), 486-486.
  • Cairns, R., Daniels, B., Wood, D., Brett, J. (2016). ADHD medication overdose and misuse: the NSW Poisons Information Centre experience, 2004-2014. Medical Journal of Australia, 204(4), 154.e1-154.e7. [More Information]
  • Cairns, R., Brown, J., Buckley, N. (2016). Dangerous toys: The expanding problem of water-absorbing beads. Medical Journal of Australia, 205(11), 528. [More Information]
  • Schaffer, A., Buckley, N., Cairns, R., Pearson, S. (2016). Interrupted time series analysis of the effect of rescheduling alprazolam in Australia: Taking control of prescription drug use. JAMA Internal Medicine, 176(8), 1223-1225. [More Information]
  • Cairns, R., Brown, J., Buckley, N. (2016). The impact of codeine re-scheduling on misuse: a retrospective review of calls to Australia's largest poisons centre. Addiction, 111(10), 1848-1853. [More Information]
  • Chitty, K., Osborne, N., Cairns, R., Dawson, A., Buckley, N. (2016). Trends in recreational poisoning in Newcastle, Australia, between 1996 and 2013. Drug and Alcohol Dependence, 159, 17-25. [More Information]
  • Alvarez-Guaita, A., Vila de Muga, S., Owen, D., Williamson, D., Magenau, A., Garcia-Melero, A., Reverter, M., Hoque, M., Cairns, R., Cornely, R., Grewal, T., et al (2015). Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. British Journal of Pharmacology, 172(7), 1677-1690. [More Information]
  • Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information]
  • Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014). Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling, 26(6), 1213-1225. [More Information]
  • Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., de Muga, S., Alvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grewal, T., et al (2014). Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports, 7(3), 883-897. [More Information]
  • Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vila de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Grewal, T., et al (2013). Annexin A6 is a scaffold for PKC(alpha) to promote EGFR inactivation. Oncogene, 32(23), 2858-2872. [More Information]
  • Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Grewal, T., et al (2013). Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One, 8(4), 1-10. [More Information]
  • Reverter, M., Rentero, C., Vila de Muga, S., Alvarez-Guaita, A., Mulay, V., Cairns, R., Wood, P., Monastyrskaya, K., Pol, A., Tebar, F., Grewal, T., et al (2011). Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function. Molecular Biology of the Cell, 22(21), 4108-4123. [More Information]

2018

  • Bell, J., Bentley, J., Downie, C., Cairns, R., Buckley, N., Katelaris, A., Pearson, S., Nassar, N. (2018). Accidental pharmacological poisonings in young children: population-based study in three settings. Clinical Toxicology, 56(8), 782-789. [More Information]
  • Peacock, A., Larance, B., Farrell, M., Cairns, R., Buckley, N., Degenhardt, L. (2018). Opioid use and harms associated with a sustained-release tapentadol formulation: a postmarketing study protocol. BMJ Open, 8(3), 1-6. [More Information]
  • Ngo, A., Cairns, R., Brown, J., Lynch, A., Robinson, J., Wylie, C., Buckley, N., Dawson, A. (2018). Patterns of poisoning exposure at different ages: the 2015 annual report of the Australian Poisons Information Centres. Medical Journal of Australia, 209(2), 74-79.

2017

  • Balaban, S., Shearer, R., Lee, L., van Geldermalsen, M., Schreuder, M., Shtein, H., Cairns, R., Thomas, K., Fazakerley, D., Grewal, T., Holst, J., Hoy, A., et al (2017). Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer and Metabolism, 5(1). [More Information]
  • Cooper, J., Brown, J., Cairns, R., Ibister, G. (2017). Desvenlafaxine overdose and the occurrence of serotonin toxicity, seizures and cardiovascular effects. Clinical Toxicology, 55(1), 18-24. [More Information]
  • Osborne, N., Cairns, R., Dawson, A., Chitty, K., Buckley, N. (2017). Epidemiology of coronial deaths from pesticide ingestion in Australia. International Journal of Hygiene and Environmental Health, 220(2), 478-484. [More Information]
  • Cairns, R., Alvarez-Guaita, A., Mart�nez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]
  • Cairns, R., Brown, J., Gunja, N., Buckley, N. (2017). The impact of Australian legislative changes on synthetic cannabinoid exposures reported to the New South Wales Poisons Information Centre. International Journal of Drug Policy, 43, 74-82. [More Information]
  • Cairns, R., Buckley, N. (2017). The Poisoning Severity Score: If It Did Not Exist, We Would Have To Invent It. Journal of Medical Toxicology, 13(2), 131-134. [More Information]

2016

  • Cairns, R., Brown, J., Lynch, A., Robinson, J., Wylie, C., Buckley, N. (2016). A decade of Australian methotrexate dosing errors. Medical Journal of Australia, 204(10), 384.e1-384.e6. [More Information]
  • Cairns, R., Brown, J., Buckley, N. (2016). A decade of Australian methotrexate dosing errors. Medical Journal of Australia, 205(10), 486-486.
  • Cairns, R., Daniels, B., Wood, D., Brett, J. (2016). ADHD medication overdose and misuse: the NSW Poisons Information Centre experience, 2004-2014. Medical Journal of Australia, 204(4), 154.e1-154.e7. [More Information]
  • Cairns, R., Brown, J., Buckley, N. (2016). Dangerous toys: The expanding problem of water-absorbing beads. Medical Journal of Australia, 205(11), 528. [More Information]
  • Schaffer, A., Buckley, N., Cairns, R., Pearson, S. (2016). Interrupted time series analysis of the effect of rescheduling alprazolam in Australia: Taking control of prescription drug use. JAMA Internal Medicine, 176(8), 1223-1225. [More Information]
  • Cairns, R., Brown, J., Buckley, N. (2016). The impact of codeine re-scheduling on misuse: a retrospective review of calls to Australia's largest poisons centre. Addiction, 111(10), 1848-1853. [More Information]
  • Chitty, K., Osborne, N., Cairns, R., Dawson, A., Buckley, N. (2016). Trends in recreational poisoning in Newcastle, Australia, between 1996 and 2013. Drug and Alcohol Dependence, 159, 17-25. [More Information]

2015

  • Alvarez-Guaita, A., Vila de Muga, S., Owen, D., Williamson, D., Magenau, A., Garcia-Melero, A., Reverter, M., Hoque, M., Cairns, R., Cornely, R., Grewal, T., et al (2015). Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains. British Journal of Pharmacology, 172(7), 1677-1690. [More Information]
  • Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information]

2014

  • Hoque, M., Rentero, C., Cairns, R., Tebar, F., Enrich, C., Grewal, T. (2014). Annexins - scaffolds modulating PKC localization and signaling. Cellular Signalling, 26(6), 1213-1225. [More Information]
  • Tebar, F., Gelabert-Baldrich, M., Hoque, M., Cairns, R., Rentero, C., Pol, A., Grewal, T., Enrich, C. (2014). Annexins and Endosomal Signaling. In John N Abelson, Melvin I. Simon, Anna Marie Pyle, Gregory L. Verdine (Eds.), Methods in Enzymology, (pp. 55-74). San Diego: Academic Press. [More Information]
  • Reverter, M., Rentero, C., Garcia-Melero, A., Hoque, M., de Muga, S., Alvarez-Guaita, A., Conway, J., Wood, P., Cairns, R., Lykopoulou, L., Grewal, T., et al (2014). Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries. Cell Reports, 7(3), 883-897. [More Information]

2013

  • Koese, M., Rentero, C., Kota, B., Hoque, M., Cairns, R., Wood, P., Vila de Muga, S., Reverter, M., Alvarez-Guaita, A., Monastyrskaya, K., Grewal, T., et al (2013). Annexin A6 is a scaffold for PKC(alpha) to promote EGFR inactivation. Oncogene, 32(23), 2858-2872. [More Information]
  • Mulay, V., Wood, P., Manetsch, M., Darabi, M., Cairns, R., Hoque, M., Chan, K., Reverter, M., Alvarez-Guaita, A., Rye, K., Grewal, T., et al (2013). Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and HuH7 Cells. PloS One, 8(4), 1-10. [More Information]

2011

  • Reverter, M., Rentero, C., Vila de Muga, S., Alvarez-Guaita, A., Mulay, V., Cairns, R., Wood, P., Monastyrskaya, K., Pol, A., Tebar, F., Grewal, T., et al (2011). Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function. Molecular Biology of the Cell, 22(21), 4108-4123. [More Information]

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