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Associate Professor Ross Grant

Clinical Associate Professor
Medicine, Sydney Adventist Hospital Clinical School

Telephone 9487 9602
Fax 9487 9626

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Research interests

Oxidative stress (OS) is a complex biochemical process involving free radical damage that results in degenerative changes to the body’s cells. The degree of OS and cell damage that a body experiences is impacted by diet and lifestyle choices. A lifetime of OS leads to cellular deterioration and contributes significantly to ageing and degenerative disorders such asthe neurodegenerative dementias (e.g. Alzheimer's),heart disease and cancer.

Nicotinamide Adenine Dinucleotide (NAD+) is a ubiquitous molecule found in all cells of the body and is classically known to play an essential role in electron transferfor ATP (energy) production.However more recently, NAD+ has been shown to act as an essential substrate for important activities such as the base excision repair of DNA (via PARP activity) and activation ofthe sirtuin family of enzymes (linked to cell longevity).OS induced DNA damage can deplete the cells NAD+ through over-activation of PARP. This loss of NAD+ can significantly reduce sirtuin activity potentiallyimpacting cell and tissue health.

Over the past 10 years Dr Grant has published a number of research papers on the impact of oxidative stress induced NAD+ depletion on health and brain cell survival. His current research interests include; nutritional effects on adolescent vascular and neurobiological health and the effect of various lifestyle choices on the induction of oxidative stress in the young and older population and its relationship to NAD(H) metabolism and disease.

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Selected publications

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Journals

  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014). Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology, 15, 177-198. [More Information]
  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014). Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence. Biogerontology, 15(2), 177-198. [More Information]
  • Guest, J., Garg, M., Bilgin, A., Grant, R. (2013). Relationship between central and peripheral fatty acids in humans. Lipids in Health and Disease, 12(1), 79-79. [More Information]
  • Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., Guillemin, G. (2012). Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. PLoS One, 7(7), 1-9. [More Information]
  • Guest, J., Grant, R. (2012). Effects of dietary derived antioxidants on the central nervous system. International Journal of Nutrition, Pharmacology, Neurological Diseases, 2(3), 185-197. [More Information]
  • Massudi, H., Grant, R., Guillemin, G., Braidy, N. (2012). NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns. Redox Report, 17(1), 28-46. [More Information]
  • Pope, B., Mitsakos, K., Bilgin, A., Hokin, B., Grant, R. (2012). Predicting overall viability of cord blood harvests. Transfusion, 52(5), 1079-1085. [More Information]
  • Grant, R. (2012). Taking note of modifiable neurobiological risk factors in adolescent depression. International Journal of Nutrition, Pharmacology, Neurological Diseases, 2(3), 165-166. [More Information]
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Poljak, A., Grant, R. (2011). Age related changes in NAD+ metabolism oxidative stress and sirt1 activity in wistar rats. PLoS One, 6(4), e19194 - 1-e19194 - 18. [More Information]
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Grant, R. (2011). Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. The FEBS Journal, 278(22), 4425-4434. [More Information]
  • Braidy, N., Guillemin, G., Grant, R. (2011). Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons. International Journal of Tryptophan Research, 4, 29-37. [More Information]
  • Grant, R., Grohmann, G., Baines, S., Bilgin, A., Guest, J., Morris, M., Pearce, R., Rossignol-Grant, C., Zeuschner, C. (2010). Evidence for under-nutrition in adolescent females using routine dieting practices. Asia Pacific Journal of Clinical Nutrition, 19(4), 526-533. [More Information]
  • Grant, R., Nguyen, S., Guillemin, G. (2010). Kynurenine pathway metabolism is involved in the maintenance of the intracellular NAD+ concentration in human primary astrocytes. International Journal of Tryptophan Research, 3, 151-156. [More Information]
  • Braidy, N., Grant, R., Adams, S., Guillemin, G. (2010). Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons. The FEBS Journal, 277(2), 368-382. [More Information]
  • Mach, J., Midgley, A., Dank, S., Grant, R., Bentley, D. (2010). The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H). Nutrients, 2(3), 319-329. [More Information]
  • Chen, Y., Stankovic, R., Cullen, K., Meininger, V., Garner, B., Coggan, S., Grant, R., Brew, B., Guillemin, G. (2010). The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis. Neurotoxicity Research, 18(2), 132-142. [More Information]
  • Grant, R., Coggan, S., Smythe, G., Bilgin, A., Gregory, K. (2009). Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid. Journal of Neurochemistry, 108(5), 1220-1225. [More Information]
  • Braidy, N., Grant, R., Brew, B., Adams, S., Jayasena, T., Guillemin, G. (2009). Effects of Kynurenine Pathway Metabolites on Intracellular NAD+ synthesis and Cell Death in Human Primary Astrocytes and Neurons. International Journal of Tryptophan Research, 2, 61-69.
  • Braidy, N., Grant, R., Adams, S., Brew, B., Guillemin, G. (2009). Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotoxicity Research, 16(1), 77-86. [More Information]
  • Grant, R., Coggan, S., Smythe, G. (2009). The physiological action of picolinic Acid in the human brain. International Journal of Tryptophan Research, 2, 71-79. [More Information]
  • Braidy, N., Guillemin, G., Grant, R. (2008). Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease. Neurotoxicity Research, 13(3-Apr), 173-84. [More Information]
  • Braidy, N., Guillemin, G., Grant, R. (2008). Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease. Neurotoxicity Research, 13(3/4), 173-184. [More Information]
  • Grant, R., Bilgin, A., Zeuschner, C., Guy, T., Pearce, R., Hokin, B., Ashton, J. (2008). The relative impact of a vegetable-rich diet on key markers of health in a cohort of Australian adolescents. Asia Pacific Journal of Clinical Nutrition, 17(1), 107-115. [More Information]
  • Jayasena, T., Grant, R., Keerthisinghe, N., Solaja, I., Smythe, G. (2007). Membrane permeability of redox active metal chelators: an important element in reducing hydroxyl radical induced NAD+ depletion in neuronal cells. Neuroscience Research, 57(3), 454-461. [More Information]
  • Poljak, A., Grant, R., Austin, C., Jamie, J., Willows, R., Takikawa, O., Littlejohn, T., Truscott, R., Walker, M., Sachdev, P., et al (2006). Inhibition of indoleamine 2,3 dioxygenase activity by H2O2. Archives of Biochemistry and Biophysics, 450(1), 9-19. [More Information]

2014

  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014). Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence. Biogerontology, 15, 177-198. [More Information]
  • Braidy, N., Poljak, A., Grant, R., Jayasena, T., Mansour, H., Chan-Ling, T., Guillemin, G., Smythe, G., Sachdev, P. (2014). Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence. Biogerontology, 15(2), 177-198. [More Information]

2013

  • Guest, J., Garg, M., Bilgin, A., Grant, R. (2013). Relationship between central and peripheral fatty acids in humans. Lipids in Health and Disease, 12(1), 79-79. [More Information]

2012

  • Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., Guillemin, G. (2012). Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. PLoS One, 7(7), 1-9. [More Information]
  • Guest, J., Grant, R. (2012). Effects of dietary derived antioxidants on the central nervous system. International Journal of Nutrition, Pharmacology, Neurological Diseases, 2(3), 185-197. [More Information]
  • Massudi, H., Grant, R., Guillemin, G., Braidy, N. (2012). NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns. Redox Report, 17(1), 28-46. [More Information]
  • Pope, B., Mitsakos, K., Bilgin, A., Hokin, B., Grant, R. (2012). Predicting overall viability of cord blood harvests. Transfusion, 52(5), 1079-1085. [More Information]
  • Grant, R. (2012). Taking note of modifiable neurobiological risk factors in adolescent depression. International Journal of Nutrition, Pharmacology, Neurological Diseases, 2(3), 165-166. [More Information]

2011

  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Poljak, A., Grant, R. (2011). Age related changes in NAD+ metabolism oxidative stress and sirt1 activity in wistar rats. PLoS One, 6(4), e19194 - 1-e19194 - 18. [More Information]
  • Braidy, N., Guillemin, G., Mansour, H., Chan-Ling, T., Grant, R. (2011). Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats. The FEBS Journal, 278(22), 4425-4434. [More Information]
  • Braidy, N., Guillemin, G., Grant, R. (2011). Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons. International Journal of Tryptophan Research, 4, 29-37. [More Information]

2010

  • Grant, R., Grohmann, G., Baines, S., Bilgin, A., Guest, J., Morris, M., Pearce, R., Rossignol-Grant, C., Zeuschner, C. (2010). Evidence for under-nutrition in adolescent females using routine dieting practices. Asia Pacific Journal of Clinical Nutrition, 19(4), 526-533. [More Information]
  • Grant, R., Nguyen, S., Guillemin, G. (2010). Kynurenine pathway metabolism is involved in the maintenance of the intracellular NAD+ concentration in human primary astrocytes. International Journal of Tryptophan Research, 3, 151-156. [More Information]
  • Braidy, N., Grant, R., Adams, S., Guillemin, G. (2010). Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons. The FEBS Journal, 277(2), 368-382. [More Information]
  • Mach, J., Midgley, A., Dank, S., Grant, R., Bentley, D. (2010). The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H). Nutrients, 2(3), 319-329. [More Information]
  • Chen, Y., Stankovic, R., Cullen, K., Meininger, V., Garner, B., Coggan, S., Grant, R., Brew, B., Guillemin, G. (2010). The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis. Neurotoxicity Research, 18(2), 132-142. [More Information]

2009

  • Grant, R., Coggan, S., Smythe, G., Bilgin, A., Gregory, K. (2009). Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid. Journal of Neurochemistry, 108(5), 1220-1225. [More Information]
  • Braidy, N., Grant, R., Brew, B., Adams, S., Jayasena, T., Guillemin, G. (2009). Effects of Kynurenine Pathway Metabolites on Intracellular NAD+ synthesis and Cell Death in Human Primary Astrocytes and Neurons. International Journal of Tryptophan Research, 2, 61-69.
  • Braidy, N., Grant, R., Adams, S., Brew, B., Guillemin, G. (2009). Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons. Neurotoxicity Research, 16(1), 77-86. [More Information]
  • Grant, R., Coggan, S., Smythe, G. (2009). The physiological action of picolinic Acid in the human brain. International Journal of Tryptophan Research, 2, 71-79. [More Information]

2008

  • Braidy, N., Guillemin, G., Grant, R. (2008). Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease. Neurotoxicity Research, 13(3-Apr), 173-84. [More Information]
  • Braidy, N., Guillemin, G., Grant, R. (2008). Promotion of cellular NAD(+) anabolism: therapeutic potential for oxidative stress in ageing and Alzheimer's disease. Neurotoxicity Research, 13(3/4), 173-184. [More Information]
  • Grant, R., Bilgin, A., Zeuschner, C., Guy, T., Pearce, R., Hokin, B., Ashton, J. (2008). The relative impact of a vegetable-rich diet on key markers of health in a cohort of Australian adolescents. Asia Pacific Journal of Clinical Nutrition, 17(1), 107-115. [More Information]

2007

  • Jayasena, T., Grant, R., Keerthisinghe, N., Solaja, I., Smythe, G. (2007). Membrane permeability of redox active metal chelators: an important element in reducing hydroxyl radical induced NAD+ depletion in neuronal cells. Neuroscience Research, 57(3), 454-461. [More Information]

2006

  • Poljak, A., Grant, R., Austin, C., Jamie, J., Willows, R., Takikawa, O., Littlejohn, T., Truscott, R., Walker, M., Sachdev, P., et al (2006). Inhibition of indoleamine 2,3 dioxygenase activity by H2O2. Archives of Biochemistry and Biophysics, 450(1), 9-19. [More Information]
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