Dr Ruby Lin

Associate Professor
Centre for Infectious Diseases and Microbiology

Telephone 0286273414

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Australasian Genomic Technologies Association

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Biographical details

Ruby joined Iredell lab at the end of October 2017 after a short stint in industry. She is the project manager for Iredell lab and the scientific lead for an investigator-led clinical trial involving treatment of severe Staphylococcal infections using bacteriophage therapy. Her research focus has been microRNA driven dysfunctions in eukaryotic disease model systems including mouse/rat models and humans. She was a named NHMRC Peter Doherty fellow, 2005-8 and UNSW Global postdoctoral fellow, 2009-14. She has acquired >A$5.1m in competitive funding. She has 5 seminal papers in BMJ, 1999, Nature, 2010, ATVB, 2010, PNAS, 2012 and Faseb J, 2014, all received media coverage, high impact and have high citation index. She has presented >65 papers at >30 conferences and cross-disciplinary seminars as invited chair and speaker. She is a conjoint Associate Professor at UNSW. During her presidency at Australasian Genomic Technologies Association (AGTA), a prominent society in genomics in Australia and NZ with members from industry and academia, she implemented gender equality at its annual meetings. She is heavily involved in promoting gender balance and women in STEM through various professional networks. She continues to train honours, PhD and postdoctoral researchers. She is a regular guest lecturer at UNSW, UTS and Macquarie University. In her spare time she volunteers as the primary ethics coordinator at her kids’ school and helps P & C with fundraising events. She also does pro bono work as a career coach.

Selected publications

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Journals

  • Schelch, K., Wagner, C., Hager, S., Pirker, C., Siess, K., Lang, E., Lin, R., Kirschner, M., Mohr, T., Brcic, L., Reid, G., van Zandwijk, N., et al (2018). FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal. Carcinogenesis, 39(4), 534-545. [More Information]
  • Duncan, T., Lowe, A., Sidhu, K., Sachdev, P., Lewis, T., Lin, R., Sytnyk, V., Valenzuela, M. (2017). Replicable Expansion and Differentiation of Neural Precursors from Adult Canine Skin. Stem cell reports, 9(2), 557-570. [More Information]
  • Ooi, J., Bernardo, B., Singla, S., Patterson, N., Lin, R., McMullen, J. (2016). Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases. RNA Biology, 14(5), 500-513. [More Information]
  • Bernardo, B., Nguyen, S., Gao, X., Tham, Y., Ooi, J., Patterson, N., Kiriazis, H., Su, Y., Thomas, C., Lin, R., et al (2016). Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload. Scientific Reports, 6, 22442. [More Information]
  • Bernardo, B., Ooi, J., Matsumoto, A., Tham, Y., Singla, S., Kiriazis, H., Patterson, N., Sadoshima, J., Obad, S., Lin, R., et al (2016). Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: Identification of sex-, disease- and treatment-regulated miRNAs. Journal of Physiology, 594(20), 5959-5974. [More Information]
  • Bernardo, B., Ooi, J., Lin, R., McMullen, J. (2015). miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart. Future Medicinal Chemistry, 7(13), 1771-1792. [More Information]
  • Liu, L., Jiang, Q., Wang, X., Zhang, Y., Lin, R., Lam, S., Shui, G., Zhou, L., Li, P., Wang, Y., et al (2014). Adipose-specific knockout of seipin/bscl2 results in progressive lipodystrophy. Diabetes, 63(7), 2320-2331. [More Information]
  • Lin, R., Ng, S., Morris, M. (2014). Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity. Genomics Data, 2, 351-353. [More Information]
  • Bernardo, B., Gao, X., Tham, Y., Kiriazis, H., Winbanks, C., Ooi, J., Boey, E., Obad, S., Kauppinen, S., Gregorevic, P., et al (2014). Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy. PloS One, 9(2), 1-13. [More Information]
  • Bernardo, B., Nguyen, S., Winbanks, C., Gao, X., Boey, E., Tham, Y., Kiriazis, H., Ooi, J., Porrello, E., Lin, R., et al (2014). Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy. The FASEB Journal, 28(12), 597-5110. [More Information]
  • Bernardo, B., Charchar, F., Lin, R., McMullen, J. (2012). A microRNA guide for clinicians and basic scientists: background and experimental techniques. Heart, Lung and Circulation, 21(3), 131-142. [More Information]
  • Cooley, N., Cowley, M., Lin, R., Marasco, S., Wong, C., Kaye, D., Dart, A., Woodcock, E. (2012). Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease. Physiological Genomics, 44(3), 211-219. [More Information]
  • Bernardo, B., Gao, X., Winbanks, C., Boey, E., Tham, Y., Kiriazis, H., Gregorevic, P., Obad, S., Kauppinen, S., Du, X., et al (2012). Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proceedings of the National Academy of Sciences of the United States of America, 109(43), 17615-17620. [More Information]
  • Fei, W., Shui, G., Zhang, Y., Krahmer, N., Ferguson, C., Kapterian, T., Lin, R., Dawes, I., Brown, A., Li, P., et al (2011). A role for phosphatidic Acid in the formation of supersized" lipid droplets". PLoS Genetics, 7(7), e1002201. [More Information]
  • Huang, K., Lin, R., Kormas, N., Lee, L., Chen, C., Gill, T., Caterson, I. (2004). Plasma Leptin Is Associated With Insulin Resistance Independent Of Age, Body Mass Index, Fat Mass, Lipids, And Pubertal Development In Nondiabetic Adolescents. International Journal of Obesity, 28(4), 470-475. [More Information]
  • Lin, R., Wang, X., Morris, B. (2003). Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension, 41(3), 404-407. [More Information]
  • Lin, R., Dalziel, B., Caterson, I., Wang, X., Morris, B. (2003). Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S Variant. Obesity Research, 11(6), 802-808. [More Information]
  • Morris, B., Benjafield, A., Lin, R. (2003). Essential hypertension: genes and dreams. Clinical Chemistry and Laboratory Medicine, 41(7), 834-844. [More Information]
  • Kumar, N., Benjafield, A., Lin, R., Wang, W., Stowasser, M., Morris, B. (2003). Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension. Journal of Hypertension, 21(7), 1331-1337. [More Information]
  • Morris, B., Lin, R., Wang, X. (2003). Response. Hypertension, 11. [More Information]
  • Morris, B., Lin, R., Dalziel, B., Caterson, I., Wang, X. (2003). Response: Central obesity is associated with glucocorticoid receptor N363S variant: Big picture sheds light. Obesity Research, 11, 1607-1609.
  • Morris, B., Lin, R., Wang, X., Dalziel, B., Caterson, I. (2003). Response: Central obesity is associated with Glucocorticoid Receptor N363S Variant: Big Picture Sheds Light. Obesity Research, 11(12), 1607-1609.
  • Lin, R., Schyvens, C., Zhang, Y., Whitworth, J., Morris, B. (2003). Tumor necrosis factor receptor 2 mRNA in rat models of hypertension. American Journal of Hypertension, 16(8), 685-688. [More Information]
  • Lin, R., Morris, B. (2002). Association analysis of polymorphisms at the interleukin-1 locus in essential hypertension. American Journal of Medical Genetics, Part A, 107(4), 311-316.
  • Hui, J., Farrell, G., Lin, R., Samarasinghe, D., Liddle, C., George, J., Kench, J., Byth, K. (2002). Hepatic Steatosis in Chronic Hepatitis C Infection. Journal of Gastroenterology and Hepatology, 17(8), 873-881.
  • Lin, R., Benjafield, A., Morris, B., Ericsson, J. (2001). Association of beta 2-adrenoceptor Gln27Glu variant with body weight but not hypertension. American Journal of Hypertension, 14, 1201-1204.
  • Benjafield, A., Lin, R., Dalziel, B., Gosby, A., Caterson, I., Morris, B. (2001). G-protein B3 subunit gene splice variant in obesity and overweight. International Journal of Obesity, 25, 777-780.

2018

  • Schelch, K., Wagner, C., Hager, S., Pirker, C., Siess, K., Lang, E., Lin, R., Kirschner, M., Mohr, T., Brcic, L., Reid, G., van Zandwijk, N., et al (2018). FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal. Carcinogenesis, 39(4), 534-545. [More Information]

2017

  • Duncan, T., Lowe, A., Sidhu, K., Sachdev, P., Lewis, T., Lin, R., Sytnyk, V., Valenzuela, M. (2017). Replicable Expansion and Differentiation of Neural Precursors from Adult Canine Skin. Stem cell reports, 9(2), 557-570. [More Information]

2016

  • Ooi, J., Bernardo, B., Singla, S., Patterson, N., Lin, R., McMullen, J. (2016). Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases. RNA Biology, 14(5), 500-513. [More Information]
  • Bernardo, B., Nguyen, S., Gao, X., Tham, Y., Ooi, J., Patterson, N., Kiriazis, H., Su, Y., Thomas, C., Lin, R., et al (2016). Inhibition of miR-154 Protects Against Cardiac Dysfunction and Fibrosis in a Mouse Model of Pressure Overload. Scientific Reports, 6, 22442. [More Information]
  • Bernardo, B., Ooi, J., Matsumoto, A., Tham, Y., Singla, S., Kiriazis, H., Patterson, N., Sadoshima, J., Obad, S., Lin, R., et al (2016). Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: Identification of sex-, disease- and treatment-regulated miRNAs. Journal of Physiology, 594(20), 5959-5974. [More Information]

2015

  • Bernardo, B., Ooi, J., Lin, R., McMullen, J. (2015). miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart. Future Medicinal Chemistry, 7(13), 1771-1792. [More Information]

2014

  • Liu, L., Jiang, Q., Wang, X., Zhang, Y., Lin, R., Lam, S., Shui, G., Zhou, L., Li, P., Wang, Y., et al (2014). Adipose-specific knockout of seipin/bscl2 results in progressive lipodystrophy. Diabetes, 63(7), 2320-2331. [More Information]
  • Lin, R., Ng, S., Morris, M. (2014). Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity. Genomics Data, 2, 351-353. [More Information]
  • Bernardo, B., Gao, X., Tham, Y., Kiriazis, H., Winbanks, C., Ooi, J., Boey, E., Obad, S., Kauppinen, S., Gregorevic, P., et al (2014). Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy. PloS One, 9(2), 1-13. [More Information]
  • Bernardo, B., Nguyen, S., Winbanks, C., Gao, X., Boey, E., Tham, Y., Kiriazis, H., Ooi, J., Porrello, E., Lin, R., et al (2014). Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy. The FASEB Journal, 28(12), 597-5110. [More Information]

2012

  • Bernardo, B., Charchar, F., Lin, R., McMullen, J. (2012). A microRNA guide for clinicians and basic scientists: background and experimental techniques. Heart, Lung and Circulation, 21(3), 131-142. [More Information]
  • Cooley, N., Cowley, M., Lin, R., Marasco, S., Wong, C., Kaye, D., Dart, A., Woodcock, E. (2012). Influence of atrial fibrillation on microRNA expression profiles in left and right atria from patients with valvular heart disease. Physiological Genomics, 44(3), 211-219. [More Information]
  • Bernardo, B., Gao, X., Winbanks, C., Boey, E., Tham, Y., Kiriazis, H., Gregorevic, P., Obad, S., Kauppinen, S., Du, X., et al (2012). Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function. Proceedings of the National Academy of Sciences of the United States of America, 109(43), 17615-17620. [More Information]

2011

  • Fei, W., Shui, G., Zhang, Y., Krahmer, N., Ferguson, C., Kapterian, T., Lin, R., Dawes, I., Brown, A., Li, P., et al (2011). A role for phosphatidic Acid in the formation of supersized" lipid droplets". PLoS Genetics, 7(7), e1002201. [More Information]

2004

  • Huang, K., Lin, R., Kormas, N., Lee, L., Chen, C., Gill, T., Caterson, I. (2004). Plasma Leptin Is Associated With Insulin Resistance Independent Of Age, Body Mass Index, Fat Mass, Lipids, And Pubertal Development In Nondiabetic Adolescents. International Journal of Obesity, 28(4), 470-475. [More Information]

2003

  • Lin, R., Wang, X., Morris, B. (2003). Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension, 41(3), 404-407. [More Information]
  • Lin, R., Dalziel, B., Caterson, I., Wang, X., Morris, B. (2003). Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S Variant. Obesity Research, 11(6), 802-808. [More Information]
  • Morris, B., Benjafield, A., Lin, R. (2003). Essential hypertension: genes and dreams. Clinical Chemistry and Laboratory Medicine, 41(7), 834-844. [More Information]
  • Kumar, N., Benjafield, A., Lin, R., Wang, W., Stowasser, M., Morris, B. (2003). Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension. Journal of Hypertension, 21(7), 1331-1337. [More Information]
  • Morris, B., Lin, R., Wang, X. (2003). Response. Hypertension, 11. [More Information]
  • Morris, B., Lin, R., Dalziel, B., Caterson, I., Wang, X. (2003). Response: Central obesity is associated with glucocorticoid receptor N363S variant: Big picture sheds light. Obesity Research, 11, 1607-1609.
  • Morris, B., Lin, R., Wang, X., Dalziel, B., Caterson, I. (2003). Response: Central obesity is associated with Glucocorticoid Receptor N363S Variant: Big Picture Sheds Light. Obesity Research, 11(12), 1607-1609.
  • Lin, R., Schyvens, C., Zhang, Y., Whitworth, J., Morris, B. (2003). Tumor necrosis factor receptor 2 mRNA in rat models of hypertension. American Journal of Hypertension, 16(8), 685-688. [More Information]

2002

  • Lin, R., Morris, B. (2002). Association analysis of polymorphisms at the interleukin-1 locus in essential hypertension. American Journal of Medical Genetics, Part A, 107(4), 311-316.
  • Hui, J., Farrell, G., Lin, R., Samarasinghe, D., Liddle, C., George, J., Kench, J., Byth, K. (2002). Hepatic Steatosis in Chronic Hepatitis C Infection. Journal of Gastroenterology and Hepatology, 17(8), 873-881.

2001

  • Lin, R., Benjafield, A., Morris, B., Ericsson, J. (2001). Association of beta 2-adrenoceptor Gln27Glu variant with body weight but not hypertension. American Journal of Hypertension, 14, 1201-1204.
  • Benjafield, A., Lin, R., Dalziel, B., Gosby, A., Caterson, I., Morris, B. (2001). G-protein B3 subunit gene splice variant in obesity and overweight. International Journal of Obesity, 25, 777-780.

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