Dr Rujee Duke

Honorary Associate
Pharmacology, School of Medical Sciences

Telephone +61 2 9114 0509
Fax +61 2 9351 3868

Map

International links

China

(Sun Yutsen University) Professor Yang Depo Faculty of Pharmaceutical Sciences

Germany

(Department of Forensic Medicine, University of Freiburg) Professor Dr. med. Sigrun Chrubasik

United Kingdom

(University of Cambridge) Dr Sarah Lummis Department of Biochemistry

United States

(Michigan State University) A/Professor Zachery Huang Department of Entomology

Selected grants

2008

  • Australian propolis as a source of complementary medicines; Duke C, Duke R, Tran V; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Cage compounds as blockers of GABA and glycine receptor channels; Moorhouse A, Johnston G, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Novel GABA receptors in rat cerebellum, hippocampus, retina and spinal cord; Johnston G, Collins M, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.

1999

  • Molecular pharmacology of GABA-C receptor subtypes; Collins M, Johnston G, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Vlachojannis, J., Duke, R., Tran, V., Duke, C., Chrubasik, S. (2009). Anti-inflammatory herbal medicines for the control of pain. In Carpinella, Maria Cecilia; Rai, Mahendra (Eds.), Novel Therapeutic Agents from Plants, (pp. 339-367). New Hampshire, USA: Science Publishers Inc.
  • Razmovski-Naumovski, V., Duke, R., Tran, V., Li, G., Tattam, B., Roufogalis, B., Duke, C. (2008). Current methods in the isolation and characterisation of saponins from Gynostemma pentaphyllum. In Francesco Epifano (Eds.), Current Trends in Phytochemistry, (pp. 283-309). Kerala, India: Research Signpost.
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]

Journals

  • Koolaji, N., Abu-Mellal, A., Tran, V., Duke, R., Duke, C. (2013). Synthesis of C- and O-prenylated tetrahydroxystilbenes and O-prenylated cinnamates and their action towards cancer cells. European Journal of Medicinal Chemistry, 63, 415-422. [More Information]
  • Thompson, A., McGonigle, I., Duke, R., Johnston, G., Lummis, S. (2012). A single amino acid determines the toxicity of Ginkgo biloba extracts. The FASEB Journal, 26(5), 1884-1891. [More Information]
  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Collins, M., Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the ginkgolides at recombinant human r1 GABAc receptors. Neuropharmacology, 63(6), 1127-1139. [More Information]
  • Abu-Mellal, A., Koolaji, N., Duke, R., Tran, V., Duke, C. (2012). Prenylated cinnamate and stilbenes from Kangaroo Island propolis and their antioxidant activity. Phytochemistry, 77, 251-259. [More Information]
  • Tran, V., Duke, R., Abu-Mellal, A., Duke, C. (2012). Propolis with high flavonoid content collected by honey bees from Acacia paradoxa. Phytochemistry, 81, 126-132. [More Information]
  • Thompson, A., Duke, R., Lummis, S. (2011). Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor. Molecular Pharmacology, 80(1), 183-190. [More Information]
  • Thompson, A., Jarvis, G., Duke, R., Johnston, G., Lummis, S. (2011). Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology, 60, 488-495. [More Information]
  • Tran, V., Marks, D., Duke, R., Bebawy, M., Duke, C., Roufogalis, B. (2011). Modulation of P-glycoprotein-Mediated Anticancer Drug Accumulation, Cytotoxicity, and ATPase Activity by Flavonoid Interactions. Nutrition and Cancer: an international journal, 63(3), 435-443. [More Information]
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Li, Z., Tran, V., Duke, R., Ng, C., Yang, D., Duke, C. (2009). Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids. Chemistry and Physics of Lipids, 158, 39-45. [More Information]
  • Cui, P., Duke, R., Duke, C. (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. Chemistry and Physics of Lipids, 152(2), 122-130. [More Information]
  • Cui, P., Duke, R., Tattam, B., Duke, C. (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 2: mass spectral characterization. Chemistry and Physics of Lipids, 152(2), 65-70. [More Information]
  • Chrubasik, J., Duke, R., Chrubasik, S. (2007). Mise a jour de la monographie allemande de la commission E sur Petasites hybridus (Petasite officinal). Phytotherapie, 5, 135-136.
  • Chrubasik, J., Duke, R., Chrubasik, S. (2007). Mise a jour de la monographie allemande de la commission E sur Petasites hybridus (petasite officinal). Phytotherapie, 5(3), 135-136.
  • Agosti, R., Duke, R., Chrubasik, J., Chrubasik, S. (2006). Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review. Phytomedicine, 13(9-10), 743-746. [More Information]
  • Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Johnston, G., Jordan, M., Collins, M. (2006). Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Information]
  • Huang, H., Tran, V., Duke, R., Tan, S., Chrubasik, S., Roufogalis, B., Duke, C. (2006). Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kB activation. Journal of Ethnopharmacology, 104(1-2), 149-155. [More Information]
  • Lee, J., Duke, R., Tran, V., Hook, J., Duke, C. (2006). Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry, 67(23), 2550-2560. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2006). Mixed antagonistic effects of bilobalide at rho(1) GABA(C) receptor. Neuroscience, 137(2), 607-617. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.
  • Chrubasik, C., Duke, R., Chrubasik, S. (2006). The evidence for clinical efficacy of rose hip and seed: A systematic review. Phytotherapy Research, 20(1), 1-3. [More Information]
  • Razmovski-Naumovski, V., Duke, R., Turner, P., Duke, C. (2005). (20S)-2 alpha,3 beta,12 beta-trihydroxydammar-24-ene 20-O-beta-D-glucopyranoside (Gynosaponin TN1) as the 2.5-methanol solvate. Acta Crystallographica. Section E: Structure Reports Online, E61, o1239-o1241.
  • Huang, H., Razmovski-Naumovski, V., Salam, N., Duke, R., Tran, V., Duke, C., Roufogalis, B. (2005). A novel LXR-a activator identified from the natural product Gynostemma pentaphyllum. Biochemical Pharmacology, 70(9), 1298-1308. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Ginkgo Biloba, As Antagonists At Recombinant Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of Pharmacology, 494(2-3), 131-138. [More Information]
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Duke, R., Collins, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751.
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA receptors. European Journal of Pharmacology, 464(1), 1-8.
  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Duke, R., Collins, M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Collins, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889.
  • Collins, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192.

Conferences

  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Bilobalide, from Ginkgo biloba, and enhancement of wild type alpha-1 beta-2gamma-2l GABAa receptors by diazepam, pentobarbitone and a steroid. 3rd College of Health Sciences Research Conference, Sydney: University of Sydney.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Effects of bilobalide and the sesquiterpene of Ginkgo bilobaon GABA-mediated currents modulated by GABAa modulators. 20th International Australasian Winter Conference on Brain Research.
  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha-1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. Australian Health and Meldical Research Conference.
  • Campbell, E., Duke, R., Johnston, G., Granger, R. (2002). Valerian and GABA receptors. Australian Health and Medical Research Congress.

2013

  • Koolaji, N., Abu-Mellal, A., Tran, V., Duke, R., Duke, C. (2013). Synthesis of C- and O-prenylated tetrahydroxystilbenes and O-prenylated cinnamates and their action towards cancer cells. European Journal of Medicinal Chemistry, 63, 415-422. [More Information]

2012

  • Thompson, A., McGonigle, I., Duke, R., Johnston, G., Lummis, S. (2012). A single amino acid determines the toxicity of Ginkgo biloba extracts. The FASEB Journal, 26(5), 1884-1891. [More Information]
  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Collins, M., Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the ginkgolides at recombinant human r1 GABAc receptors. Neuropharmacology, 63(6), 1127-1139. [More Information]
  • Abu-Mellal, A., Koolaji, N., Duke, R., Tran, V., Duke, C. (2012). Prenylated cinnamate and stilbenes from Kangaroo Island propolis and their antioxidant activity. Phytochemistry, 77, 251-259. [More Information]
  • Tran, V., Duke, R., Abu-Mellal, A., Duke, C. (2012). Propolis with high flavonoid content collected by honey bees from Acacia paradoxa. Phytochemistry, 81, 126-132. [More Information]

2011

  • Thompson, A., Duke, R., Lummis, S. (2011). Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor. Molecular Pharmacology, 80(1), 183-190. [More Information]
  • Thompson, A., Jarvis, G., Duke, R., Johnston, G., Lummis, S. (2011). Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology, 60, 488-495. [More Information]
  • Tran, V., Marks, D., Duke, R., Bebawy, M., Duke, C., Roufogalis, B. (2011). Modulation of P-glycoprotein-Mediated Anticancer Drug Accumulation, Cytotoxicity, and ATPase Activity by Flavonoid Interactions. Nutrition and Cancer: an international journal, 63(3), 435-443. [More Information]

2009

  • Vlachojannis, J., Duke, R., Tran, V., Duke, C., Chrubasik, S. (2009). Anti-inflammatory herbal medicines for the control of pain. In Carpinella, Maria Cecilia; Rai, Mahendra (Eds.), Novel Therapeutic Agents from Plants, (pp. 339-367). New Hampshire, USA: Science Publishers Inc.
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Li, Z., Tran, V., Duke, R., Ng, C., Yang, D., Duke, C. (2009). Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids. Chemistry and Physics of Lipids, 158, 39-45. [More Information]

2008

  • Razmovski-Naumovski, V., Duke, R., Tran, V., Li, G., Tattam, B., Roufogalis, B., Duke, C. (2008). Current methods in the isolation and characterisation of saponins from Gynostemma pentaphyllum. In Francesco Epifano (Eds.), Current Trends in Phytochemistry, (pp. 283-309). Kerala, India: Research Signpost.
  • Cui, P., Duke, R., Duke, C. (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. Chemistry and Physics of Lipids, 152(2), 122-130. [More Information]
  • Cui, P., Duke, R., Tattam, B., Duke, C. (2008). Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 2: mass spectral characterization. Chemistry and Physics of Lipids, 152(2), 65-70. [More Information]

2007

  • Chrubasik, J., Duke, R., Chrubasik, S. (2007). Mise a jour de la monographie allemande de la commission E sur Petasites hybridus (Petasite officinal). Phytotherapie, 5, 135-136.
  • Chrubasik, J., Duke, R., Chrubasik, S. (2007). Mise a jour de la monographie allemande de la commission E sur Petasites hybridus (petasite officinal). Phytotherapie, 5(3), 135-136.

2006

  • Agosti, R., Duke, R., Chrubasik, J., Chrubasik, S. (2006). Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review. Phytomedicine, 13(9-10), 743-746. [More Information]
  • Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Johnston, G., Jordan, M., Collins, M. (2006). Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Information]
  • Huang, H., Tran, V., Duke, R., Tan, S., Chrubasik, S., Roufogalis, B., Duke, C. (2006). Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kB activation. Journal of Ethnopharmacology, 104(1-2), 149-155. [More Information]
  • Lee, J., Duke, R., Tran, V., Hook, J., Duke, C. (2006). Hyperforin and its analogues inhibit CYP3A4 enzyme activity. Phytochemistry, 67(23), 2550-2560. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2006). Mixed antagonistic effects of bilobalide at rho(1) GABA(C) receptor. Neuroscience, 137(2), 607-617. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.
  • Chrubasik, C., Duke, R., Chrubasik, S. (2006). The evidence for clinical efficacy of rose hip and seed: A systematic review. Phytotherapy Research, 20(1), 1-3. [More Information]

2005

  • Razmovski-Naumovski, V., Duke, R., Turner, P., Duke, C. (2005). (20S)-2 alpha,3 beta,12 beta-trihydroxydammar-24-ene 20-O-beta-D-glucopyranoside (Gynosaponin TN1) as the 2.5-methanol solvate. Acta Crystallographica. Section E: Structure Reports Online, E61, o1239-o1241.
  • Huang, H., Razmovski-Naumovski, V., Salam, N., Duke, R., Tran, V., Duke, C., Roufogalis, B. (2005). A novel LXR-a activator identified from the natural product Gynostemma pentaphyllum. Biochemical Pharmacology, 70(9), 1298-1308. [More Information]

2004

  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Ginkgo Biloba, As Antagonists At Recombinant Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of Pharmacology, 494(2-3), 131-138. [More Information]
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Duke, R., Collins, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751.

2003

  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA receptors. European Journal of Pharmacology, 464(1), 1-8.
  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.

2002

  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Bilobalide, from Ginkgo biloba, and enhancement of wild type alpha-1 beta-2gamma-2l GABAa receptors by diazepam, pentobarbitone and a steroid. 3rd College of Health Sciences Research Conference, Sydney: University of Sydney.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Effects of bilobalide and the sesquiterpene of Ginkgo bilobaon GABA-mediated currents modulated by GABAa modulators. 20th International Australasian Winter Conference on Brain Research.
  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Duke, R., Collins, M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha-1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. Australian Health and Meldical Research Conference.
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Collins, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889.
  • Campbell, E., Duke, R., Johnston, G., Granger, R. (2002). Valerian and GABA receptors. Australian Health and Medical Research Congress.

2001

  • Collins, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192.

To update your profile click here. For support on your academic profile contact .