Associate Professor Russell Diefenbach

Honorary Principal Research Fellow
Sydney Medical School (Westmead)
The Westmead Institute for Medical Research

Telephone 61298502764

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Current research students

Project title Research student
Investigating the role of envelope glycoprotein E in herpes simplex virus type-1 egress Chris DENES

International links

Switzerland

(University of Zurich) CoChief Investigator

Selected grants

2017

  • Defining the mechanism of assembly of herpes simplex virus in the neuronal growth cone and its subsequent exit to epithelial cells; Cunningham A, Diefenbach R, Miranda Saksena M; National Health and Medical Research Council (NHMRC)/Project Grants.

2016

  • Restoring interferon production by myeloid cells infected with HIV by gene therapy; Cunningham A, Harman A, Diefenbach R, Nasr N, Kizana E; Australian Centre for HIV and Hepatitis Virology Research (ACH2)/Research Support.
  • Defining the Interaction of HIV with the Interferon System in Initial Mucosal Infection; Cunningham A, Harman A, Palmer S, Nasr N, Diefenbach R, Sandgren K; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • WAVE 20/50 Bioreactor and C5 Cell Disruptor; Chircop (nee Fabbro) M, Kizana E, Robinson P, Diefenbach R, Bryan T, Gottlieb D, Micklethwaite K, Alexander I; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The mechanism of HSV-1 transport in sensory axons and its unique assembly at the axon terminus; Cunningham A, Diefenbach R, Miranda Saksena M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Assembly and egress of herpes simplex virus; Diefenbach R; DVC Research/Bridging Support Grant.
  • Development of small molecule inhibitors of HIV envelope-Langerin interactions and of HIV uptake by Langerhans Cells (LCs) as topical (genital) microbicides; Cunningham A, Nasr N, Diefenbach R; Australian Centre for HIV and Hepatitis Virology Research/Research Grant.

2013

  • Fluidigm BioMark HD - HX; Alexander I, Jamieson R, Chircop (nee Fabbro) M, Byrne J, Catchpoole D, Reddel R, Tam P, Robinson P, Bryan T, Diefenbach R; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Functional roles of the tegument proteins of herpes simplex virus type 1; Diefenbach R, Fraefel C, Kelly B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Development of inhibitors of dynein-dependent transport of HIV: a new antiviral strategy; Diefenbach R, Turville S, Cunningham A; Australian Centre for HIV and Hepatitis Virology Research (ACH2)/Research Support.
  • The fate of single virus particles during infection; Newsome T, Diefenbach R; Australian Research Council (ARC)/Discovery Projects (DP).

2009

  • Transport, assembly and egress of Herpes Simplex virus in neurones; Cunningham A, Diefenbach R, Miranda Saksena M; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Biological probes for understanding mammalian cellular transport mechanisms; Diefenbach R, Miranda Saksena M, Cunningham A; Australian Research Council (ARC)/Linkage Projects (LP).

2007

  • Assembly and egress of herpes simplex virus; Diefenbach R, Fraefel C; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Transport and egress of herpes simplex virus in neurones; Cunningham A, Diefenbach R, Miranda Saksena M; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Zeiss axiovert 200M cell observer system; Henderson B, Cunningham A, Farrell G, Clarke C, Diefenbach R, Kefford R, Rizos H; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • Assembly and transport of herpes simplex virus within neurones?; Cunningham A, Diefenbach R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • LI-COR odyssey infrared imaging system plus assessories; Cunningham A, Diefenbach R, Kefford R, Farrell G, North K; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2000

  • Interactions between herpes simplex viral and neuronal motor proteins; Cunningham A, Diefenbach R, Armati P; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Diefenbach, R., Miranda Saksena, M., Cunningham, A. (2011). Herpes simplex virus: Microtubule-dependent transport and egress from neurons. In Russell J Diefenbach and Anthony L Cunningham (Eds.), Viral Transport, Assembly and Egress, (pp. 49-78). Kerala, India: Research Signpost.

Journals

  • Denes, C., Miranda Saksena, M., Cunningham, A., Diefenbach, R. (2018). Cytoskeletons in the closet�subversion in alphaherpesvirus infections. Viruses, 10(2). [More Information]
  • Miranda Saksena, M., Denes, C., Diefenbach, R., Cunningham, A. (2018). Infection and transport of herpes simplex virus type 1 in neurons: Role of the cytoskeleton. Viruses, 10(2). [More Information]
  • Lim, S., Lee, J., Diefenbach, R., Kefford, R., Rizos, H. (2018). Liquid biomarkers in melanoma: detection and discovery. Molecular Cancer, 17(1), 8. [More Information]
  • Talaei Zanjani, N., Miranda Saksena, M., Valtchev, P., Diefenbach, R., Hueston, L., Diefenbach, E., Sairi, F., Gomes, V., Cunningham, A., Dehghani, F. (2016). Abalone Hemocyanin Blocks the Entry of HSV-1 into Cells: a Potential New Antiviral Strategy. Antimicrobial Agents and Chemotherapy, 60(2), 1003-1012. [More Information]
  • Wu, J., Cunningham, A., Dehghani, F., Diefenbach, R. (2016). Comparison of Haliotis rubra hemocyanin isoforms 1 and 2. Gene Reports, 4, 123-130. [More Information]
  • Miranda Saksena, M., Boadle, R., Diefenbach, R., Cunningham, A. (2016). Dual role of Herpes Simplex Virus 1 pUS9 in virus anterograde axonal transport and final assembly in growth cones in distal axons. Journal of Virology, 90(5), 2653-2663. [More Information]
  • Caly, L., Kassouf, V., Moseley, G., Diefenbach, R., Cunningham, A., Jans, D. (2016). Fast track, dynein-dependent nuclear targeting of human immunodeficiency virus Vpr protein; impaired trafficking in a clinical isolate. Biochemical and Biophysical Research Communications, 470(3), 735-740. [More Information]
  • Diefenbach, R. (2015). Conserved tegument protein complexes: essential components in the assembly of herpesviruses. Virus Research, 210, 308-317. [More Information]
  • Harman, A., Nasr, N., Feetham, A., Galoyan, A., Alshehri,, A., Rambukwelle, D., Botting, R., Hiener, B., Diefenbach, E., Diefenbach, R., Kim, M., Cunningham, A., et al (2015). HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1. Journal of Virology, 89(13), 6575-6584. [More Information]
  • Sokolowski, N., Rizos, H., Diefenbach, R. (2015). Oncolytic virotherapy using herpes simplex virus: how far have we come? Oncolytic Virotherapy, 4, 207-219. [More Information]
  • Diefenbach, R., Davis, A., Miranda Saksena, M., Fernandez, M., Kelly, B., Jones, C., LaVail, J., Xue, J., Lai, J., Cunningham, A. (2015). The basic domain of HSV-1 pUS9 recruits kinesin-1 to facilitate egress from neurons. Journal of Virology, 90(4), 2102-2111. [More Information]
  • Diefenbach, R., Fraefel, C., Cunningham, A. (2014). The interaction of HSV-1 tegument proteins pUL36 and pUL37: A novel target for antivirals that inhibit viral assembly. Future Virology, 9(9), 787-789. [More Information]
  • Kelly, B., Bauerfeind, R., Binz, A., Sodeik, B., Laimbacher, A., Fraefel, C., Diefenbach, R. (2014). The interaction of the HSV-1 tegument proteins pUL36 and pUL37 is essential for secondary envelopment during viral egress. Virology, 454-455(1), 67-77. [More Information]
  • Horsington, J., Lynn, H., Turnbull, L., Cheng, D., Braet, F., Diefenbach, R., Whitchurch, C., Karupiah, G., Newsome, T. (2013). A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus. PLoS Pathogens, 9(3), 1-15. [More Information]
  • Cunningham, A., Miranda Saksena, M., Diefenbach, R., Johnson, D. (2013). Letter in response to: Making the case: Married versus Separate models of alphaherpes virus anterograde transport in axons. Reviews in Medical Virology, 23(6), 414-418. [More Information]
  • Kelly, B., Mijatov, B., Fraefel, C., Cunningham, A., Diefenbach, R. (2012). Identification of a single amino acid residue which is critical for the interaction between HSV-1 inner tegument proteins pUL36 and pUL37. Virology, 422(2), 308-316. [More Information]
  • Kelly, B., Diefenbach, E., Fraefel, C., Diefenbach, R. (2012). Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37. Biochemical and Biophysical Research Communications, 417(3), 961-965. [More Information]
  • Lynn, H., Horsington, J., Ter, L., Han, S., Chew, Y., Diefenbach, R., Way, M., Chaudhri, G., Karupiah, G., Newsome, T. (2012). Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection In Vivo. Journal of Virology, 86(13), 7427-7443. [More Information]
  • Aggarwal, A., Miranda Saksena, M., Boadle, R., Kelly, B., Diefenbach, R., Alam, W., Cunningham, A. (2012). Ultrastructural Visualization of Individual Tegument Protein Dissociation during Entry of Herpes Simplex Virus 1 into Human and Rat Dorsal Root Ganglion Neurons. Journal of Virology, 86(11), 6123-6137. [More Information]
  • Apcarian, A., Cunningham, A., Diefenbach, R. (2010). Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26). Journal of General Virology, 91(11), 2659-2663. [More Information]
  • Morton, A., Cunningham, A., Diefenbach, R. (2010). Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane. Biochemical and Biophysical Research Communications, 391(1), 388-393. [More Information]
  • Ko, D., Cunningham, A., Diefenbach, R. (2010). The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2). Journal of Virology, 84(3), 1397-1405. [More Information]
  • Miranda Saksena, M., Boadle, R., Aggarwal, A., Tijono, B., Rixon, F., Diefenbach, R., Cunningham, A. (2009). Herpes simplex virus utilizes the large secretory vesicle pathway for anterograde transport of tegument and envelope proteins and for viral exocytosis from growth cones of human fetal axons. Journal of Virology, 83(7), 3187-3199. [More Information]
  • Lee, J., Vittone, V., Diefenbach, E., Cunningham, A., Diefenbach, R. (2008). Identification of structural protein-protein interactions of herpes simplex virus type 1. Virology, 378, 347-354. [More Information]
  • Diefenbach, R., Miranda Saksena, M., Douglas, M., Cunningham, A. (2008). Transport and egress of herpes simplex virus in neurons. Reviews in Medical Virology, 18(1), 35-51. [More Information]
  • Mijatov, B., Cunningham, A., Diefenbach, R. (2007). Residues F593 and E596 of HSV-1 tegument protein pUL36 (VP1/2) mediate binding of tegument protein pUL37. Virology, 368(1), 26-31. [More Information]
  • Cunningham, A., Diefenbach, R., Miranda Saksena, M., Bosnjak, L., Kim, M., Jones, C., Douglas, M. (2006). The cycle of human herpes simplex virus infection: virus transport and immune control. The Journal of Infectious Diseases, 194(Supplement 1), S11-S18. [More Information]
  • Vittone, V., Diefenbach, E., Triffett, D., Douglas, M., Cunningham, A., Diefenbach, R. (2005). Determination of interactions between tegument proteins of herpes simplex virus type 1. Journal of Virology, 79(15), 9566-71. [More Information]
  • Bernhard, O., Diefenbach, R., Cunningham, A. (2005). New insights into viral structure and virus-cell interactions through proteomics. Expert Review of Proteomics, 2(4), 577-588. [More Information]
  • Douglas, M., Diefenbach, R., Homa, F., Miranda Saksena, M., Rixon, F., Vittone, V., Byth Wilson, K., Cunningham, A. (2004). Herpes Simplex Virus Type 1 Capsid Protein Vp26 Interacts With Dynein Light Chains Rp3 And Tctex1 And Plays A Role In Retrograde Cellular Transport. Journal of Biological Chemistry, 279(27), 28522-28530. [More Information]
  • Diefenbach, R., Diefenbach, E., Douglas, M., Cunningham, A. (2004). The Ribosome Receptor, P180, Interacts With Kinesin Heavy Chain, KIF5B. Biochemical and Biophysical Research Communications, 319(3), 987-992. [More Information]
  • Diefenbach, R., Miranda Saksena, M., Diefenbach, E., Holland, D., Boadle, R., Armati, P., Cunningham, A. (2002). Herpes Simplex Virus Tegument Protein US11 Interacts with Conventional Kinesin Heavy Chain. Journal of Virology, 76(7), 3282-3291. [More Information]
  • Diefenbach, R., Diefenbach, E., Douglas, M., Cunningham, A. (2002). The Heavy Chain of Conventional Kinesin Interacts with the SNARE Proteins SNAP25 and SNAP23. Biochemistry, 41(50), 14906-14915. [More Information]

Patents

  • Cunningham, A., Diefenbach, R., Miranda Saksena, M., Diefenbach, E., Holland, D., Armati, P., Penfold, M. (2005). Patent No. 6953661.

2018

  • Denes, C., Miranda Saksena, M., Cunningham, A., Diefenbach, R. (2018). Cytoskeletons in the closet�subversion in alphaherpesvirus infections. Viruses, 10(2). [More Information]
  • Miranda Saksena, M., Denes, C., Diefenbach, R., Cunningham, A. (2018). Infection and transport of herpes simplex virus type 1 in neurons: Role of the cytoskeleton. Viruses, 10(2). [More Information]
  • Lim, S., Lee, J., Diefenbach, R., Kefford, R., Rizos, H. (2018). Liquid biomarkers in melanoma: detection and discovery. Molecular Cancer, 17(1), 8. [More Information]

2016

  • Talaei Zanjani, N., Miranda Saksena, M., Valtchev, P., Diefenbach, R., Hueston, L., Diefenbach, E., Sairi, F., Gomes, V., Cunningham, A., Dehghani, F. (2016). Abalone Hemocyanin Blocks the Entry of HSV-1 into Cells: a Potential New Antiviral Strategy. Antimicrobial Agents and Chemotherapy, 60(2), 1003-1012. [More Information]
  • Wu, J., Cunningham, A., Dehghani, F., Diefenbach, R. (2016). Comparison of Haliotis rubra hemocyanin isoforms 1 and 2. Gene Reports, 4, 123-130. [More Information]
  • Miranda Saksena, M., Boadle, R., Diefenbach, R., Cunningham, A. (2016). Dual role of Herpes Simplex Virus 1 pUS9 in virus anterograde axonal transport and final assembly in growth cones in distal axons. Journal of Virology, 90(5), 2653-2663. [More Information]
  • Caly, L., Kassouf, V., Moseley, G., Diefenbach, R., Cunningham, A., Jans, D. (2016). Fast track, dynein-dependent nuclear targeting of human immunodeficiency virus Vpr protein; impaired trafficking in a clinical isolate. Biochemical and Biophysical Research Communications, 470(3), 735-740. [More Information]

2015

  • Diefenbach, R. (2015). Conserved tegument protein complexes: essential components in the assembly of herpesviruses. Virus Research, 210, 308-317. [More Information]
  • Harman, A., Nasr, N., Feetham, A., Galoyan, A., Alshehri,, A., Rambukwelle, D., Botting, R., Hiener, B., Diefenbach, E., Diefenbach, R., Kim, M., Cunningham, A., et al (2015). HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1. Journal of Virology, 89(13), 6575-6584. [More Information]
  • Sokolowski, N., Rizos, H., Diefenbach, R. (2015). Oncolytic virotherapy using herpes simplex virus: how far have we come? Oncolytic Virotherapy, 4, 207-219. [More Information]
  • Diefenbach, R., Davis, A., Miranda Saksena, M., Fernandez, M., Kelly, B., Jones, C., LaVail, J., Xue, J., Lai, J., Cunningham, A. (2015). The basic domain of HSV-1 pUS9 recruits kinesin-1 to facilitate egress from neurons. Journal of Virology, 90(4), 2102-2111. [More Information]

2014

  • Diefenbach, R., Fraefel, C., Cunningham, A. (2014). The interaction of HSV-1 tegument proteins pUL36 and pUL37: A novel target for antivirals that inhibit viral assembly. Future Virology, 9(9), 787-789. [More Information]
  • Kelly, B., Bauerfeind, R., Binz, A., Sodeik, B., Laimbacher, A., Fraefel, C., Diefenbach, R. (2014). The interaction of the HSV-1 tegument proteins pUL36 and pUL37 is essential for secondary envelopment during viral egress. Virology, 454-455(1), 67-77. [More Information]

2013

  • Horsington, J., Lynn, H., Turnbull, L., Cheng, D., Braet, F., Diefenbach, R., Whitchurch, C., Karupiah, G., Newsome, T. (2013). A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus. PLoS Pathogens, 9(3), 1-15. [More Information]
  • Cunningham, A., Miranda Saksena, M., Diefenbach, R., Johnson, D. (2013). Letter in response to: Making the case: Married versus Separate models of alphaherpes virus anterograde transport in axons. Reviews in Medical Virology, 23(6), 414-418. [More Information]

2012

  • Kelly, B., Mijatov, B., Fraefel, C., Cunningham, A., Diefenbach, R. (2012). Identification of a single amino acid residue which is critical for the interaction between HSV-1 inner tegument proteins pUL36 and pUL37. Virology, 422(2), 308-316. [More Information]
  • Kelly, B., Diefenbach, E., Fraefel, C., Diefenbach, R. (2012). Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37. Biochemical and Biophysical Research Communications, 417(3), 961-965. [More Information]
  • Lynn, H., Horsington, J., Ter, L., Han, S., Chew, Y., Diefenbach, R., Way, M., Chaudhri, G., Karupiah, G., Newsome, T. (2012). Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection In Vivo. Journal of Virology, 86(13), 7427-7443. [More Information]
  • Aggarwal, A., Miranda Saksena, M., Boadle, R., Kelly, B., Diefenbach, R., Alam, W., Cunningham, A. (2012). Ultrastructural Visualization of Individual Tegument Protein Dissociation during Entry of Herpes Simplex Virus 1 into Human and Rat Dorsal Root Ganglion Neurons. Journal of Virology, 86(11), 6123-6137. [More Information]

2011

  • Diefenbach, R., Miranda Saksena, M., Cunningham, A. (2011). Herpes simplex virus: Microtubule-dependent transport and egress from neurons. In Russell J Diefenbach and Anthony L Cunningham (Eds.), Viral Transport, Assembly and Egress, (pp. 49-78). Kerala, India: Research Signpost.

2010

  • Apcarian, A., Cunningham, A., Diefenbach, R. (2010). Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26). Journal of General Virology, 91(11), 2659-2663. [More Information]
  • Morton, A., Cunningham, A., Diefenbach, R. (2010). Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane. Biochemical and Biophysical Research Communications, 391(1), 388-393. [More Information]
  • Ko, D., Cunningham, A., Diefenbach, R. (2010). The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2). Journal of Virology, 84(3), 1397-1405. [More Information]

2009

  • Miranda Saksena, M., Boadle, R., Aggarwal, A., Tijono, B., Rixon, F., Diefenbach, R., Cunningham, A. (2009). Herpes simplex virus utilizes the large secretory vesicle pathway for anterograde transport of tegument and envelope proteins and for viral exocytosis from growth cones of human fetal axons. Journal of Virology, 83(7), 3187-3199. [More Information]

2008

  • Lee, J., Vittone, V., Diefenbach, E., Cunningham, A., Diefenbach, R. (2008). Identification of structural protein-protein interactions of herpes simplex virus type 1. Virology, 378, 347-354. [More Information]
  • Diefenbach, R., Miranda Saksena, M., Douglas, M., Cunningham, A. (2008). Transport and egress of herpes simplex virus in neurons. Reviews in Medical Virology, 18(1), 35-51. [More Information]

2007

  • Mijatov, B., Cunningham, A., Diefenbach, R. (2007). Residues F593 and E596 of HSV-1 tegument protein pUL36 (VP1/2) mediate binding of tegument protein pUL37. Virology, 368(1), 26-31. [More Information]

2006

  • Cunningham, A., Diefenbach, R., Miranda Saksena, M., Bosnjak, L., Kim, M., Jones, C., Douglas, M. (2006). The cycle of human herpes simplex virus infection: virus transport and immune control. The Journal of Infectious Diseases, 194(Supplement 1), S11-S18. [More Information]

2005

  • Vittone, V., Diefenbach, E., Triffett, D., Douglas, M., Cunningham, A., Diefenbach, R. (2005). Determination of interactions between tegument proteins of herpes simplex virus type 1. Journal of Virology, 79(15), 9566-71. [More Information]
  • Cunningham, A., Diefenbach, R., Miranda Saksena, M., Diefenbach, E., Holland, D., Armati, P., Penfold, M. (2005). Patent No. 6953661.
  • Bernhard, O., Diefenbach, R., Cunningham, A. (2005). New insights into viral structure and virus-cell interactions through proteomics. Expert Review of Proteomics, 2(4), 577-588. [More Information]

2004

  • Douglas, M., Diefenbach, R., Homa, F., Miranda Saksena, M., Rixon, F., Vittone, V., Byth Wilson, K., Cunningham, A. (2004). Herpes Simplex Virus Type 1 Capsid Protein Vp26 Interacts With Dynein Light Chains Rp3 And Tctex1 And Plays A Role In Retrograde Cellular Transport. Journal of Biological Chemistry, 279(27), 28522-28530. [More Information]
  • Diefenbach, R., Diefenbach, E., Douglas, M., Cunningham, A. (2004). The Ribosome Receptor, P180, Interacts With Kinesin Heavy Chain, KIF5B. Biochemical and Biophysical Research Communications, 319(3), 987-992. [More Information]

2002

  • Diefenbach, R., Miranda Saksena, M., Diefenbach, E., Holland, D., Boadle, R., Armati, P., Cunningham, A. (2002). Herpes Simplex Virus Tegument Protein US11 Interacts with Conventional Kinesin Heavy Chain. Journal of Virology, 76(7), 3282-3291. [More Information]
  • Diefenbach, R., Diefenbach, E., Douglas, M., Cunningham, A. (2002). The Heavy Chain of Conventional Kinesin Interacts with the SNARE Proteins SNAP25 and SNAP23. Biochemistry, 41(50), 14906-14915. [More Information]

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