Dr Samantha Ginn

Senior Lecturer
Medicine, Children's Medical Research Institute

Telephone (02) 9687 2800
Fax (02) 9687 2120

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Selected grants

2010

  • Gene therapy, stress haematopoiesis and the risk of malignancy; Alexander I, Kuchel P, Rasko J, Alexander S, McCormack M, Thrasher A, Ginn S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Fleming, J., Ginn, S., Alexander, I. (2003). Dorsal root ganglia sensory neurons. In Federico (Eds.), Lentivirus Gene Engineering Protocols, (pp. 155-167). New Jersey: Humana Press.

Journals

  • Ginn, S., Alexander, I., Edelstein, M., Abedi, M., Wixon, J. (2013). Gene therapy clinical trials worldwide to 2012 - an update. Journal of Gene Medicine, 15(2), 65-77. [More Information]
  • Ginn, S., Alexander, I. (2012). Gene therapy: Progress in childhood disease. Journal of Paediatrics and Child Health, 48(6), 466-471. [More Information]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010). Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular Therapy, 18(5), 965-976. [More Information]
  • Logan, G., Wang, L., Zheng, M., Ginn, S., Coppel, R., Alexander, I. (2009). Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene Therapy (Basingstoke), 16(2), 200-210. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Curtin, J., Dane, A., Swanson, A., Alexander, I., Ginn, S. (2008). Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct. Gene Therapy (Basingstoke), 15(5), 384-390. [More Information]
  • Kizana, E., Chang, C., Cingolani, E., Sekar, R., Ramirez-Correa, G., Abraham, M., Ginn, S., Tung, L., Alexander, I., Marban, E. (2007). Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy. Circulation Research. [More Information]
  • Yu, Z., McKay, K., Van Asperen, P., Zheng, M., Fleming, J., Ginn, S., Kizana, E., Latham, M., Feneley, M., Kirkland, P., Lumbers, E., Alexander, I., et al (2007). Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb. Journal of Gene Medicine, 9(6), 429-439. [More Information]
  • Smyth, C., Ginn, S., Deakin, C., Logan, G., Alexander, I. (2007). Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood, 110(1), 91-98. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006). Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene Therapy (Basingstoke), 13(22), 1611-1615. [More Information]
  • Kizana, E., Ginn, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation, 111(4), 394-398. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Thomas, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts Modulate Cardiomyocyte Excitability: Insights from Fibroblasts with Genetically Altered Connexin43 Expression. Journal of Gene Medicine, 7(point P8 on page 1127), 1127-1127.
  • Fleming, J., Spinoulas, A., Zheng, M., Cunningham, S., Ginn, S., McQuilty, R., Rowe, P., Alexander, I. (2005). Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors. Human Gene Therapy, 16(8), 947-956. [More Information]
  • Ginn, S., Curtin, J., Kramer, B., Smyth, C., Wong, M., Kakakios, A., McCowage, G., Watson, D., Alexander, S., Latham, M., Rowe, P., Alexander, I., et al (2005). Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia. Medical Journal of Australia, 182(9), 458-463. [More Information]
  • Ginn, S., Smyth, C., Wong, M., Bennetts, B., Rowe, P., Alexander, I. (2004). A Novel Splice-Site Mutation In The Common Gamma Chain (Gammac) Gene Il2Rg Results In X-Linked Severe Combined Immunodeficiency With An Atypical Nk+ Phenotype. Human Mutation, 23(5), 522-523.
  • Ginn, S., Fleming, J., Curtin, J., Alexander, I. (2003). Gene therapy: a roller-coaster ride. Today's Life Science (Australia), 15(3), 26-29.
  • Ginn, S., Fleming, J., Rowe, P., Alexander, I. (2003). Promoter interference mediated by the U3 Region in early-generation HIV-1-Derived Lentivirus Vectors can influence detection of transgene expression in a cell-type and species-specific manner. Human Gene Therapy, 14(12), 1127-1137.

2013

  • Ginn, S., Alexander, I., Edelstein, M., Abedi, M., Wixon, J. (2013). Gene therapy clinical trials worldwide to 2012 - an update. Journal of Gene Medicine, 15(2), 65-77. [More Information]

2012

  • Ginn, S., Alexander, I. (2012). Gene therapy: Progress in childhood disease. Journal of Paediatrics and Child Health, 48(6), 466-471. [More Information]

2010

  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010). Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular Therapy, 18(5), 965-976. [More Information]

2009

  • Logan, G., Wang, L., Zheng, M., Ginn, S., Coppel, R., Alexander, I. (2009). Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene Therapy (Basingstoke), 16(2), 200-210. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]

2008

  • Curtin, J., Dane, A., Swanson, A., Alexander, I., Ginn, S. (2008). Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct. Gene Therapy (Basingstoke), 15(5), 384-390. [More Information]

2007

  • Kizana, E., Chang, C., Cingolani, E., Sekar, R., Ramirez-Correa, G., Abraham, M., Ginn, S., Tung, L., Alexander, I., Marban, E. (2007). Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy. Circulation Research. [More Information]
  • Yu, Z., McKay, K., Van Asperen, P., Zheng, M., Fleming, J., Ginn, S., Kizana, E., Latham, M., Feneley, M., Kirkland, P., Lumbers, E., Alexander, I., et al (2007). Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb. Journal of Gene Medicine, 9(6), 429-439. [More Information]
  • Smyth, C., Ginn, S., Deakin, C., Logan, G., Alexander, I. (2007). Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood, 110(1), 91-98. [More Information]

2006

  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006). Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene Therapy (Basingstoke), 13(22), 1611-1615. [More Information]

2005

  • Kizana, E., Ginn, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation, 111(4), 394-398. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Thomas, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts Modulate Cardiomyocyte Excitability: Insights from Fibroblasts with Genetically Altered Connexin43 Expression. Journal of Gene Medicine, 7(point P8 on page 1127), 1127-1127.
  • Fleming, J., Spinoulas, A., Zheng, M., Cunningham, S., Ginn, S., McQuilty, R., Rowe, P., Alexander, I. (2005). Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors. Human Gene Therapy, 16(8), 947-956. [More Information]
  • Ginn, S., Curtin, J., Kramer, B., Smyth, C., Wong, M., Kakakios, A., McCowage, G., Watson, D., Alexander, S., Latham, M., Rowe, P., Alexander, I., et al (2005). Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia. Medical Journal of Australia, 182(9), 458-463. [More Information]

2004

  • Ginn, S., Smyth, C., Wong, M., Bennetts, B., Rowe, P., Alexander, I. (2004). A Novel Splice-Site Mutation In The Common Gamma Chain (Gammac) Gene Il2Rg Results In X-Linked Severe Combined Immunodeficiency With An Atypical Nk+ Phenotype. Human Mutation, 23(5), 522-523.

2003

  • Fleming, J., Ginn, S., Alexander, I. (2003). Dorsal root ganglia sensory neurons. In Federico (Eds.), Lentivirus Gene Engineering Protocols, (pp. 155-167). New Jersey: Humana Press.
  • Ginn, S., Fleming, J., Curtin, J., Alexander, I. (2003). Gene therapy: a roller-coaster ride. Today's Life Science (Australia), 15(3), 26-29.
  • Ginn, S., Fleming, J., Rowe, P., Alexander, I. (2003). Promoter interference mediated by the U3 Region in early-generation HIV-1-Derived Lentivirus Vectors can influence detection of transgene expression in a cell-type and species-specific manner. Human Gene Therapy, 14(12), 1127-1137.

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