Dr Samantha Ginn

Senior Lecturer
Medicine, Children's Medical Research Institute

Telephone (02) 9687 2800
Fax (02) 9687 2120

Website Children's Medical Research Institute
Honours in Medical Sciences at Westmead
Australasian Gene and Cell Therapy Society

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Biographical details

Dr Samantha Ginn received her PhD from The University of Sydney in 1999 and is now a senior researcher in the Gene Therapy Research Unit at the Children’s Medical Research Institute (CMRI) at Westmead. Her research focuses on developing treatment strategies for diseases of the liver and haematopoietic system using viral vector-based gene transfer and genome editing technology. Both these organs have immense promise as targets for the treatment of genetic disease in children. Dr Ginn is the current Secretary of the Australasian Gene and Cell Therapy Society and sits on Institutional Committees for Animal Ethics, Grants Advisory, Early Career Researchers (ECRs), Gender Equity and Postgraduate Student Selection.

Research interests

The liver is an attractive target for gene therapy with the incidence of disease-causing mutations being reported as high as 1:800 births. My research focuses on developing strategies for correcting genetic metabolic disease phenotypes in humans, by modelling these in mice. I have been using recombinant vector systems based on adeno-associated virus (AAV), that is highly liver tropic, to deliver and evaluate genome editing tools in normal mouse and human hepatocytes as well as human hepatocytes derived from patients with ornithine transcarbamylase (OTC) deficiency, a urea cycle disorder, as a model system.

Selected grants

2010

  • Gene therapy, stress haematopoiesis and the risk of malignancy; Alexander I, Kuchel P, Rasko J, Alexander S, McCormack M, Thrasher A, Ginn S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Ginn, S., Alexander, I. (2016). Gene therapy. Wiley StatsRef: Statistics Reference Online, (pp. 1-19). Hoboken: John Wiley & Sons Ltd.
  • Fleming, J., Ginn, S., Alexander, I. (2003). Dorsal root ganglia sensory neurons. In Federico (Eds.), Lentivirus Gene Engineering Protocols, (pp. 155-167). New Jersey: Humana Press.

Journals

  • Ginn, S., Amaya, A., Alexander, I., Edelstein, M., Abedi, M. (2018). Gene therapy clinical trials worldwide to 2017: An update. Journal of Gene Medicine, 20(5), 1-16. [More Information]
  • Logan, G., Dane, A., Hallwirth, C., Smyth, C., Wilkie, E., Amaya, A., Zhu, E., Khandekar, N., Ginn, S., Liao, S., Cunningham, S., Sasaki, N., Cabanes-Creus, M., Tam, P., Lisowski, L., Alexander, I., et al (2017). Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome. Nature Genetics, 49(8), 1267-1273. [More Information]
  • Ginn, S., Hallwirth, C., Liao, S., Teber, E., Arthur, J., Wu, J., Lee, H., Tay, S., Hu, M., Reddel, R., Alexander, S., Alexander, I., et al (2017). Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency. Molecular Therapy - Nucleic Acids, 6, 1-14. [More Information]
  • Hallwirth, C., Garg, G., Peters, T., Kramer, B., Malani, N., Hyman, J., Ruan, X., Ginn, S., Hetherington, N., Veeravalli, L., Liddle, C., Alexander, I., et al (2015). Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions. Molecular Therapy - Methods & Clinical Development, 2, 1-10. [More Information]
  • Deakin, C., Deakin, J., Ginn, S., Young, P., Humphreys, D., Suter, C., Alexander, I., Hallwirth, C. (2014). Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence. Nucleic Acids Research, 42(16), 1-14. [More Information]
  • Ginn, S., Alexander, I., Edelstein, M., Abedi, M., Wixon, J. (2013). Gene therapy clinical trials worldwide to 2012 - an update. Journal of Gene Medicine, 15(2), 65-77. [More Information]
  • Ginn, S., Alexander, I. (2012). Gene therapy: Progress in childhood disease. Journal of Paediatrics and Child Health, 48(6), 466-471. [More Information]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010). Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular Therapy, 18(5), 965-976. [More Information]
  • Logan, G., Wang, L., Zheng, M., Ginn, S., Coppel, R., Alexander, I. (2009). Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene Therapy (Basingstoke), 16(2), 200-210. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]
  • Curtin, J., Dane, A., Swanson, A., Alexander, I., Ginn, S. (2008). Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct. Gene Therapy (Basingstoke), 15(5), 384-390. [More Information]
  • Kizana, E., Chang, C., Cingolani, E., Sekar, R., Ramirez-Correa, G., Abraham, M., Ginn, S., Tung, L., Alexander, I., Marban, E. (2007). Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy. Circulation Research, 100(11), 1597-1604. [More Information]
  • Yu, Z., McKay, K., Van Asperen, P., Zheng, M., Fleming, J., Ginn, S., Kizana, E., Latham, M., Feneley, M., Kirkland, P., Lumbers, E., Alexander, I., et al (2007). Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb. Journal of Gene Medicine, 9(6), 429-439. [More Information]
  • Smyth, C., Ginn, S., Deakin, C., Logan, G., Alexander, I. (2007). Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood, 110(1), 91-98. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006). Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene Therapy (Basingstoke), 13(22), 1611-1615. [More Information]
  • Kizana, E., Ginn, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation, 111(4), 394-398. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Thomas, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts Modulate Cardiomyocyte Excitability: Insights from Fibroblasts with Genetically Altered Connexin43 Expression. Journal of Gene Medicine, 7(point P8 on page 1127), 1127-1127.
  • Fleming, J., Spinoulas, A., Zheng, M., Cunningham, S., Ginn, S., McQuilty, R., Rowe, P., Alexander, I. (2005). Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors. Human Gene Therapy, 16(8), 947-956. [More Information]
  • Ginn, S., Curtin, J., Kramer, B., Smyth, C., Wong, M., Kakakios, A., McCowage, G., Watson, D., Alexander, S., Latham, M., Rowe, P., Alexander, I., et al (2005). Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia. Medical Journal of Australia, 182(9), 458-463. [More Information]
  • Ginn, S., Smyth, C., Wong, M., Bennetts, B., Rowe, P., Alexander, I. (2004). A Novel Splice-Site Mutation In The Common Gamma Chain (Gammac) Gene Il2Rg Results In X-Linked Severe Combined Immunodeficiency With An Atypical Nk+ Phenotype. Human Mutation, 23(5), 522-523.
  • Ginn, S., Fleming, J., Curtin, J., Alexander, I. (2003). Gene therapy: a roller-coaster ride. Today's Life Science (Australia), 15(3), 26-29.
  • Ginn, S., Fleming, J., Rowe, P., Alexander, I. (2003). Promoter interference mediated by the U3 Region in early-generation HIV-1-Derived Lentivirus Vectors can influence detection of transgene expression in a cell-type and species-specific manner. Human Gene Therapy, 14(12), 1127-1137. [More Information]

2018

  • Ginn, S., Amaya, A., Alexander, I., Edelstein, M., Abedi, M. (2018). Gene therapy clinical trials worldwide to 2017: An update. Journal of Gene Medicine, 20(5), 1-16. [More Information]

2017

  • Logan, G., Dane, A., Hallwirth, C., Smyth, C., Wilkie, E., Amaya, A., Zhu, E., Khandekar, N., Ginn, S., Liao, S., Cunningham, S., Sasaki, N., Cabanes-Creus, M., Tam, P., Lisowski, L., Alexander, I., et al (2017). Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome. Nature Genetics, 49(8), 1267-1273. [More Information]
  • Ginn, S., Hallwirth, C., Liao, S., Teber, E., Arthur, J., Wu, J., Lee, H., Tay, S., Hu, M., Reddel, R., Alexander, S., Alexander, I., et al (2017). Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency. Molecular Therapy - Nucleic Acids, 6, 1-14. [More Information]

2016

  • Ginn, S., Alexander, I. (2016). Gene therapy. Wiley StatsRef: Statistics Reference Online, (pp. 1-19). Hoboken: John Wiley & Sons Ltd.

2015

  • Hallwirth, C., Garg, G., Peters, T., Kramer, B., Malani, N., Hyman, J., Ruan, X., Ginn, S., Hetherington, N., Veeravalli, L., Liddle, C., Alexander, I., et al (2015). Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions. Molecular Therapy - Methods & Clinical Development, 2, 1-10. [More Information]

2014

  • Deakin, C., Deakin, J., Ginn, S., Young, P., Humphreys, D., Suter, C., Alexander, I., Hallwirth, C. (2014). Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence. Nucleic Acids Research, 42(16), 1-14. [More Information]

2013

  • Ginn, S., Alexander, I., Edelstein, M., Abedi, M., Wixon, J. (2013). Gene therapy clinical trials worldwide to 2012 - an update. Journal of Gene Medicine, 15(2), 65-77. [More Information]

2012

  • Ginn, S., Alexander, I. (2012). Gene therapy: Progress in childhood disease. Journal of Paediatrics and Child Health, 48(6), 466-471. [More Information]

2010

  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010). Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular Therapy, 18(5), 965-976. [More Information]

2009

  • Logan, G., Wang, L., Zheng, M., Ginn, S., Coppel, R., Alexander, I. (2009). Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene Therapy (Basingstoke), 16(2), 200-210. [More Information]
  • Liu, R., Ginn, S., Lek, M., North, K., Alexander, I., Little, D., Schindeler, A. (2009). Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1 a. BMC Musculoskeletal Disorders, 10, 51-1-51-12. [More Information]

2008

  • Curtin, J., Dane, A., Swanson, A., Alexander, I., Ginn, S. (2008). Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct. Gene Therapy (Basingstoke), 15(5), 384-390. [More Information]

2007

  • Kizana, E., Chang, C., Cingolani, E., Sekar, R., Ramirez-Correa, G., Abraham, M., Ginn, S., Tung, L., Alexander, I., Marban, E. (2007). Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy. Circulation Research, 100(11), 1597-1604. [More Information]
  • Yu, Z., McKay, K., Van Asperen, P., Zheng, M., Fleming, J., Ginn, S., Kizana, E., Latham, M., Feneley, M., Kirkland, P., Lumbers, E., Alexander, I., et al (2007). Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb. Journal of Gene Medicine, 9(6), 429-439. [More Information]
  • Smyth, C., Ginn, S., Deakin, C., Logan, G., Alexander, I. (2007). Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood, 110(1), 91-98. [More Information]

2006

  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006). Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene Therapy (Basingstoke), 13(22), 1611-1615. [More Information]

2005

  • Kizana, E., Ginn, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation, 111(4), 394-398. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Thomas, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts Modulate Cardiomyocyte Excitability: Insights from Fibroblasts with Genetically Altered Connexin43 Expression. Journal of Gene Medicine, 7(point P8 on page 1127), 1127-1127.
  • Fleming, J., Spinoulas, A., Zheng, M., Cunningham, S., Ginn, S., McQuilty, R., Rowe, P., Alexander, I. (2005). Partial correction of sensitivity to oxidant stress in Friedreich ataxia patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors. Human Gene Therapy, 16(8), 947-956. [More Information]
  • Ginn, S., Curtin, J., Kramer, B., Smyth, C., Wong, M., Kakakios, A., McCowage, G., Watson, D., Alexander, S., Latham, M., Rowe, P., Alexander, I., et al (2005). Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia. Medical Journal of Australia, 182(9), 458-463. [More Information]

2004

  • Ginn, S., Smyth, C., Wong, M., Bennetts, B., Rowe, P., Alexander, I. (2004). A Novel Splice-Site Mutation In The Common Gamma Chain (Gammac) Gene Il2Rg Results In X-Linked Severe Combined Immunodeficiency With An Atypical Nk+ Phenotype. Human Mutation, 23(5), 522-523.

2003

  • Fleming, J., Ginn, S., Alexander, I. (2003). Dorsal root ganglia sensory neurons. In Federico (Eds.), Lentivirus Gene Engineering Protocols, (pp. 155-167). New Jersey: Humana Press.
  • Ginn, S., Fleming, J., Curtin, J., Alexander, I. (2003). Gene therapy: a roller-coaster ride. Today's Life Science (Australia), 15(3), 26-29.
  • Ginn, S., Fleming, J., Rowe, P., Alexander, I. (2003). Promoter interference mediated by the U3 Region in early-generation HIV-1-Derived Lentivirus Vectors can influence detection of transgene expression in a cell-type and species-specific manner. Human Gene Therapy, 14(12), 1127-1137. [More Information]

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