Associate Professor Sarah Hilmer

Conjoint Associate Professor
Medicine, Northern Clinical School

Telephone +61 2 9926 7632
Fax +61 2 9926 7614

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Selected grants

2013

  • Insights from ageing and calorie restriction for the prevention and treatment of paracetamol hepatotoxicity; Hilmer S, Kane A, Le Couteur D, Cogger V; Australian Association of Gerontology/RM Gibson Research Grants.
  • A randomised controlled trial of deprescribing to optimise medical therapy for frail older people: the Opti-Med study; Hilmer S, Naganathan V, McLachlan A, Comans T, Etherton-Beer C, Potter K; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • High risk prescribing in older Australians; Banks E, Le Couteur D, Pearson S, McLachlan A, Viney R, Hilmer S, Gnjidic D, Blyth F; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Drug Burden Index and association with adverse outcomes in community-dwelling people with alzheimer's disease; Gnjidic D, Hilmer S; Alzheimers Australia/Rosemary Foundation Travel Grant.

2010

  • The increasing burden of stroke with ageing: using CARAT to optimise preventative treatment in the community; Bajorek B, Krass I, Hilmer S, Magin P; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Drug Induced Liver Disease (DILD) in Old Age: understanding age-related suceptibility and pathogenesis; Hilmer S; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Effects of aging on Hepatic Drug Clearance and Mechanisms of Drug Induced Liver Disease; Hilmer S, Jones B, Cogger V, De Cabo R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Optimising pain management in frail older people; McLachlan A, Naganathan V, Le Couteur D, Hilmer S, Gibson S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ageing, Werner syndrome and Pseudocapillarization; Le Couteur D, Cogger V, Lebel M, Quinn R, Hilmer S, McCuskey R; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Caloric restriction, ageing and the liver sinusoidal endothelium: mechanisms and implications; Le Couteur D, De Cabo R, De Cabo R, Cogger V, Hilmer S, Frazer R; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Research into the ageing liver; Hilmer S; Royal Australasian College of Surgeons/Sir Roy McCaughy Research Fellowship.

Selected publications

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Book Chapters

  • Hilmer, S., Gnjidic, D. (2014). Frailty. In Gideon Kaplan (Eds.), Geriatric Medicine: An Introduction, (pp. 189-201). Melbourne, VIC: IP Communications.
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2010). Dosing Errors: Age-Related Changes in Pharmacokinetics. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 127-135). New York: Springer Science + Business Media.
  • Hilmer, S., Ford, G. (2009). General Principals of Pharmacology. In J. Halter, J. Ouslander, M. Tinetti, S. Studenski, K. High, S. Asthana (Eds.), Hazzard’s Principles of Geriatric Medicine and Gerontology (6th ed), (pp. 103-122). United States of America: McGraw Hill.
  • Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.

Journals

  • Kashyap, M., Belleville, S., Mulsant, B., Hilmer, S., Paquette, A., Tu, L., Tannenbaum, C. (2014). Methodological challenges in determining longitudinal associations between anticholinergic drug use and incident cognitive decline. Journal of the American Geriatrics Society, 62(2), 336-341. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Bell, J. (2014). Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology, 28(1), 10-19. [More Information]
  • Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
  • Narayan, S., Hilmer, S., Horsburgh, S., Nishtala, P. (2013). Anticholinergic component of the drug burden index and the anticholinergic drug scale as measures of anticholinergic exposure in older people in New Zealand: a population-level study. Drugs and Aging, 30(11), 927-934. [More Information]
  • Gnjidic, D., Hilmer, S. (2013). Discontinuation of risperidone in Alzheimer's disease. The New England Journal of Medicine, 368(2), 186-186. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2013). Discontinuation of statins in routine care settings. Annals of Internal Medicine, 159(1), 73-74. [More Information]
  • Gnjidic, D., Le Couteur, D., Pearson, S., McLachlan, A., Viney, R., Hilmer, S., Blyth, F., Joshy, G., Banks, E. (2013). High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health, 13, 1-9. [More Information]
  • Best, O., Gnjidic, D., Hilmer, S., Naganathan, V., McLachlan, A. (2013). Investigating polypharmacy and drug burden index in hospitalised older people. Internal Medicine Journal, 43(8), 912-918. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Letter: Rethinking psychotropics in nursing homes. Medical Journal of Australia, 199(2), 99-99. [More Information]
  • Bennett, A., Gnjidic, D., Hilmer, S. (2013). Medication exposure may confound the association between dietary intake and frailty. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 68(11), 1440-1440. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2013). Optimal cutoff of polypharmacy and outcomes - reply. Journal of Clinical Epidemiology, 66(4), 465-466. [More Information]
  • Johnston, C., Kirkpatrick, C., McLachlan, A., Hilmer, S. (2013). Physiologically Based Pharmacokinetic Modeling at the Extremes of Age. Clinical Pharmacology and Therapeutics, 93(2), 148-148. [More Information]
  • Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., et al (2013). Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review, 32(2), 218-222. [More Information]
  • Gnjidic, D., Bell, S., Hilmer, S. (2013). Re-evaluating psychotropic drug use across care settings. Journal of the American Geriatrics Society, 61(9), 1640-1641. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Rethinking psychotropics in nursing homes. Medical Journal of Australia. [More Information]
  • Nguyen, T., Hilmer, S., Cumming, R. (2013). Review of epidemiology and management of atrial fibrillation in developing countries. International Journal of Cardiology, 167(6), 2412-2420. [More Information]
  • Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013). Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open, 3(3), 1-10. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Statins in older adults. Australian Prescriber, 36(3), 79-82.
  • McCarthy, R., Hilmer, S. (2013). Teaching Junior Medical Officers safe and effective prescribing. Internal Medicine Journal, 43(11), 1250-1253. [More Information]
  • Gnjidic, D., Wilson, N., Hilmer, S. (2013). Understanding drug effects in older people: the role of pharmacology. JAMA Internal Medicine, 173(20), 1930. [More Information]
  • Tannenbaum, C., Paquette, A., Hilmer, S., Holroyd-Leduc, J., Carnahan, R. (2012). A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs and Aging, 29(8), 639-658. [More Information]
  • Wilson, N., Hilmer, S., March, L., Chen, J., Gnjidic, D., Mason, R., Cameron, I., Sambrook, P. (2012). Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities. Drugs and Aging, 29(2), 157-165. [More Information]
  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Gnjidic, D., Le Couteur, D., Kouladjian, L., Hilmer, S. (2012). Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clinics in Geriatric Medicine, 28(2), 237-253. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2012). Drug Burden Index and Beers Criteria: Impact on Functional Outcomes in Older People Living in Self-Care Retirement Villages. The Journal of Clinical Pharmacology, 52(2), 258-265. [More Information]
  • Lonnroos, E., Gnjidic, D., Hilmer, S., Bell, J., Kautiaien, H., Sulkava, R., Hartikainen, S. (2012). Drug Burden Index and Hospitalization among Community-Dwelling Older People. Drugs and Aging, 29(5), 395-404. [More Information]
  • Gnjidic, D., Bell, S., Hilmer, S., Lonnroos, E., Sulkava, R., Hartikainen, S. (2012). Drug Burden Index associated with function in community-dwelling older people in Finland: A cross-sectional study. Annals of Medicine, 44(5), 458-467. [More Information]
  • Lowry, E., Woodman, R., Soiza, R., Hilmer, S., Mangoni, A. (2012). Drug burden index, physical function, and adverse outcomes in older hospitalized patients. Journal of Clinical Pharmacology, 52(10), 1584-1591. [More Information]
  • Gnjidic, D., Le Couteur, D., Naganathan, V., Cumming, R., Creasey, H., Waite, L., Sharma, A., Blyth, F., Hilmer, S. (2012). Effects of drug burden index on cognitive function in older men. Journal of Clinical Psychopharmacology, 32(2), 273-277. [More Information]
  • Gnjidic, D., Hilmer, S. (2012). Emergency hospitalizations for adverse drug events. The New England Journal of Medicine, 366(9), 859-859. [More Information]
  • Mitchell, S., Hilmer, S., Kirkpatrick, C., Hansen, R., Williamson, D., Singh, N., Finnegan, T., Allen, B., Diamond, T., Diwan, A., Lloyd, B., Smith, E., Fiatarone Singh, M. (2012). Estimation of lean body weight in older women with hip fracture. The Journal of Nutrition, Health and Aging, 16(2), 188-192. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology and Therapeutics, 91(3), 521-528. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2012). High-risk prescribing in older people: More harm than good? Aging Health, 8(4), 325-327. [More Information]
  • Bell, S., Le Couteur, D., McLachlan, A., Chen, T., Moles, R., Basger, B., Hilmer, S. (2012). Improving medicine selection for older people: Do we need an Australian classification for inappropriate medicines use? Australian Family Physician, 41(1/2), 9-10. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2012). Off-Label Use of Medicines: Time for Action. Clinical Pharmacology and Therapeutics, 92(2), 157-157. [More Information]
  • Hilmer, S., Gnjidic, D., Abernethy, D. (2012). Pharmacoepidemiology in the Postmarketing Assessment of the Safety and Efficacy of Drugs in Older Adults. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 181-188. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012). Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989-995. [More Information]
  • Gnjidic, D., Hilmer, S. (2012). POTENTIAL CONTRIBUTION OF MEDICATIONS TO FRAILTY. Journal of the American Geriatrics Society, 60(2), 401-401. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Hilmer, S., Gnjidic, D., Le Couteur, D. (2012). Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Australian Family Physician, 41(12), 924-928. [More Information]
  • McCarthy, R., Ogle, S., Finnegan, T., Hilmer, S. (2012). Which Aged Care inpatients are potentially suitable for community-based acute care? Australasian Journal on Ageing, 31(1), 56-59. [More Information]
  • Johnston, C., Carroll, P., Matthews, S., Mitchell, S., Hilmer, S. (2011). 'You look like a 240 mg': Gentamicin dosing at a Sydney hospital. Journal of Pharmacy Practice and Research, 41(4), 275-277.
  • Mitchell, S., Kane, A., Hilmer, S. (2011). Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Current Gerontology and Geriatrics Research, 2011, 1-14. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Seibel, M., Mason, R., Chen, J., Cumming, R., Sambrook, P. (2011). Associations Between Drug Burden Index and Falls in Older People in Residential Aged Care. Journal of the American Geriatrics Society, 59(5), 875-880. [More Information]
  • McLachlan, A., Bath, S., Naganathan, V., Hilmer, S., Le Couteur, D., Gibson, S., Blyth, F. (2011). Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. British Journal of Clinical Pharmacology, 71(3), 351-364. [More Information]
  • Hardy, J., Hilmer, S. (2011). Deprescribing in the Last Year of Life. Journal of Pharmacy Practice and Research, 41(2), 146-151.
  • Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., et al (2011). Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178. [More Information]
  • Hilmer, S., Tran, K., Rubie, P., Wright, J., Gnjidic, D., Mitchell, S., Matthews, S., Carroll, P. (2011). Gentamicin Pharmacokinetics in Old Age and Frailty. British Journal of Clinical Pharmacology, 71(2), 224-231. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2011). Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Cogger, V., Hilmer, S., Svistounov, D. (2011). Mechanisms and implications of age-related changes in the liver. Current Gerontology and Geriatrics Research, 2011, 150364-150364. [More Information]
  • Hilmer, S., March, L., Sambrook, P., Wilson, N. (2011). Medication safety in residential aged-care facilities: a perspective. Therapeutic Advances in Drug Safety, 1(1), 11-20. [More Information]
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Mason, R., Sambrook, P. (2011). Physical functioning measures and risk of falling in older people living in residential aged care facilities. Therapeutic Advances in Musculoskeletal Disease, 3(1), 9-15. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2011). Reducing drugs in older adults is more. Archives of Internal Medicine, 171(9), 868-869. [More Information]
  • Wilson, N., Gnjidic, D., Hilmer, S. (2011). Safe Drug Use in Residential Aged Care Facilities. Geriatric Medicine in General Practice, 9, 6-8.
  • Wilson, N., Gnjidic, D., March, L., Sambrook, P., Hilmer, S. (2011). Use of PPIs Are Not Associated With Mortality in Institutionalized Older People. Archives of Internal Medicine, 171(9), 866-866. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2010). A Pilot Randomized Clinical Trial Utilizing the Drug Burden Index to Reduce Exposure to Anticholinergic and Sedative Medications in Older People. The Annals of Pharmacotherapy, 44(11), 1725-1732. [More Information]
  • Hilmer, S., Gnjidic, D. (2010). Adverse drug reactions in older people. Geriatric Medicine in General Practice, 4, 32-33.
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Seibel, M., Sambrook, P. (2010). Associations between drug burden index and physical function in older people in residential aged care facilities. Age and Ageing, 39(4), 503-507. [More Information]
  • Castelino, R., Hilmer, S., Bajorek, B., Nishtala, S., Chen, T. (2010). Drug Burden Index and potentially inappropriate medications in community-dwelling older people: the impact of Home Medicines Review. Drugs and Aging, 27(2), 135-148. [More Information]
  • Mitchell, S., Hilmer, S. (2010). Drug-Induced Liver Injury in Older Adults. Therapeutic Advances in Drug Safety, 1(2), 65-77. [More Information]
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
  • Perera, V., Hilmer, S., McLachlan, A. (2010). Frailty should be assessed using validated scales. Drugs and Aging, 27(8), 687. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2010). Hepatotoxicity of therapeutic short-course paracetamol inhospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335.
  • Joester, J., Vogler, C., Chang, K., Hilmer, S. (2010). Hypnosedative use and predictors of successful withdrawal in new patients attending a falls clinic: a retrospective, cohort study. Drugs and Aging, 27(11), 915-924. [More Information]
  • Wilson, N., March, L., Sambrook, P., Hilmer, S. (2010). Medication Safety in Residential Aged Care: a Perspective. Therapeutic Advances in Drug Safety, 1(1), 11-20. [More Information]
  • Gnjidic, D., Hilmer, S. (2010). Multiple medications and assessment of inappropriate medication use in older adults. Geriatric Medicine in General Practice, 6, 24-25.
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2010). Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. International Journal of Infectious Diseases, 14(10), e857-e867. [More Information]
  • Murnion, B., Gnjidic, D., Hilmer, S. (2010). Prescription and Administration of Opioids to Hospital In-patients, and Barriers to Effective Use. Pain Medicine, 11, 58-66. [More Information]
  • Ogle, S., Foster, K., Hilmer, S., Broadfoot, A., Thanh, H. (2010). Teaching Geriatric Medicine in Vietnam: Introduction of an interactive learning module for medical students. Australasian Journal on Ageing, 29(3). [More Information]
  • Gnjidic, D., Hilmer, S. (2010). Use of Potentially Inappropriate Medications in the Care of Frail Older People. Aging Health, 6(6), 705-716. [More Information]
  • Boudreau, R., Hanlon, J., Roumani, Y., Studenski, S., Ruby, C., Wright, R., Hilmer, S., Shorr, R., Bauer, D., Simonsick, E., et al (2009). Central nervous system medication use and incident mobility limitation in community elders: the health, aging, and body composition study. Pharmacoepidemiology and Drug Safety: an international journal, 18(10), 916-922. [More Information]
  • Mitchell, S., Hilmer, S., McLachlan, A. (2009). Clinical pharmacology of analgesics in old age and frailty. Reviews in Clinical Gerontology, 19(2), 103-118. [More Information]
  • Mitchell, S., Murnion, B., Matthews, S., Hilmer, S. (2009). Compliance with Paracetamol Prescribing Policies at a Sydney Hospital. Journal of Pharmacy Practice and Research, 39(2), 122-127.
  • Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
  • Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009). Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology, 68(1), 97-105. [More Information]
  • Hilmer, S., Mager, D., Simonsick, E., Ling, S., Windham, G., Harris, T., Shorr, R., Bauer, D., Abernethy, D. (2009). Drug burden index score and functional decline in older people. The American Journal of Medicine, 122(12), 1142-1149. [More Information]
  • Wright, R., Roumani, Y., Boudreau, R., Newman, A., Ruby, C., Studenski, S., Shorr, R., Bauer, D., Simonsick, E., Hilmer, S., et al (2009). Effect of Central Nervous System Medication Use on Decline in Cognition in Community-Dwelling Older Adults: Findings from the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society, 57(2), 243-250. [More Information]
  • Nishtala, S., Hilmer, S., McLachlan, A., Hannan, P., Chen, T. (2009). Impact of Residential Medication Management Reviews on Drug Burden Index in Aged-Care Homes - A Retrospective Analysis. Drugs and Aging, 26(8), 677-686. [More Information]
  • Hanlon, J., Boudreau, R., Roumani, Y., Newman, A., Ruby, C., Wright, R., Hilmer, S., Shorr, R., Bauer, D., Simonsick, E., et al (2009). Number and Dosage of Central Nervous System Medications on Recurrent Falls in Community Elders: The Health, Aging and Body Composition Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 64A(4), 492-498. [More Information]
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2009). Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. Pathology, 41(7), 615-621. [More Information]
  • Hilmer, S., Perera, V., Mitchell, S., Murnion, B., Dent, J., Bajorek, B., Matthews, S., Rolfson, D. (2009). The assessment of frailty in older people in acute care. Australasian Journal on Ageing, 28(4), 182-188. [More Information]
  • Hilmer, S., Gnjidic, D. (2009). The effects of polypharmacy in older adults. Clinical Pharmacology and Therapeutics, 85(1), 86-8. [More Information]
  • Perera, V., Bajorek, B., Matthews, S., Hilmer, S. (2009). The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age and Ageing, 38(2), 156-162. [More Information]
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2009). Variability in response to medicines in older people: Phenotypic and genotypic factors. Clinical Pharmacology and Therapeutics, 85(4), 431-433. [More Information]
  • Mitchell, S., Hilmer, S. (2009). What dose? Pharmacokinetic and pharmacodynamic changes in ageing and frailty. Geriatric Medicine in General Practice, 3, 30-31.
  • Hilmer, S. (2008). ADME-tox issues for the elderly. Expert Opinion on Drug Metabolism and Toxicology, 4(10), 1321-1331. [More Information]
  • Gnjidic, D., Murnion, B., Hilmer, S. (2008). Age and opioid analgesia in an acute hospital population. Age and Ageing, 37(6), 699-702. [More Information]
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
  • Hilmer, S., Abernethy, D. (2008). Measures of drug toxicity in older adults. Archives of Internal Medicine, 168(17), 1930-1931. [More Information]
  • Cao, Y., Mager, D., Simonsick, E., Hilmer, S., Ling, S., Windham, B., Crentsil, V., Yasar, S., Fried, L., Abernethy, D. (2008). Physical and Cognitive Performance and Burden of Anticholinergics, Sedatives, and ACE Inhibitors in Older Women. Pharmacology and Therapeutics, 83(3), 422-429. [More Information]
  • Cheluvappa, R., Shimmon, R., Dawson, M., Hilmer, S., Le Couteur, D. (2008). Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochimica Polonica, 55(3), 571-580. [More Information]
  • Hilmer, S., Mager, D., Simonsick, E., Cao, Y., Ling, S., Windham, G., Harris, T., Hanlon, J., Rubin, S., Shorr, R., et al (2007). A drug burden index to define the functional burden of medications in older people. Archives of Internal Medicine, 167(8), 781-787. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Hilmer, S., McLachlan, A., Le Couteur, D. (2007). Clinical pharmacology in the geriatric patient. Fundamental and Clinical Pharmacology, 21(3), 217-230. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. New York Academy of Sciences. Annals, 1114, 88-92. [More Information]
  • Hilmer, S., Rangiah, C., Bajorek, B., Shenfield, G. (2007). Failure to weigh patients in hospital: a medication safety risk. Internal Medicine Journal, 37(9), 647-650. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]
  • Lopez-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M., Allard, J., Ingram, D., Navas, P., et al (2006). Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 103(6), 1768-1773.
  • Everitt, A., Hilmer, S., Brand-Miller, J., Jamieson, H., Truswell, A., Sharma, A., Mason, R., Morris, B., Le Couteur, D. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1(1), 11-31.
  • Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
  • Hilmer, S., Heap, T., Eckstein, R., Lauer, C. (2006). Microscopic colitis associated with exposure to lansoprazole. Medical Journal of Australia, 184(4), 185-6. [More Information]
  • Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
  • Hilmer, S., Seale, J. (2005). Alternatives to injectable opioids for acute analgesia. Medicine Today, 6, 39-47.
  • Everitt, A., Roth, G., Le Couteur, D., Hilmer, S. (2005). Calorie restriction versus drug therapy to delay the onset of ageing diseases and extend life. Age, 27(1), 39-48. [More Information]
  • Hilmer, S., Shenfield, G., Le Couteur, D. (2005). Clinical Implications of Changes in Hepatic Drug Metabolism in Older People. Therapeutics and Clinical Risk Management, 1(2), 151-156.
  • Le Couteur, D., Fraser, R., Hilmer, S., Rivory, L., McLean, A. (2005). The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clinical Pharmacokinetics, 44(2), 187-200. [More Information]
  • Cumming, R., Glasgow, N., Le Couteur, D., Naganathan, V., Hilmer, S. (2004). Prescribing In Older People. Australian Family Physician, 33(10), 777-781.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799.
  • Hilmer, S., Naganathan, V., Le Couteur, D. (2003). Why do physicians choose to train in geriatric medicine? Australasian Journal on Ageing, 11(3), 160-162.

2014

  • Hilmer, S., Gnjidic, D. (2014). Frailty. In Gideon Kaplan (Eds.), Geriatric Medicine: An Introduction, (pp. 189-201). Melbourne, VIC: IP Communications.
  • Kashyap, M., Belleville, S., Mulsant, B., Hilmer, S., Paquette, A., Tu, L., Tannenbaum, C. (2014). Methodological challenges in determining longitudinal associations between anticholinergic drug use and incident cognitive decline. Journal of the American Geriatrics Society, 62(2), 336-341. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Bell, J. (2014). Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology, 28(1), 10-19. [More Information]
  • Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]

2013

  • Narayan, S., Hilmer, S., Horsburgh, S., Nishtala, P. (2013). Anticholinergic component of the drug burden index and the anticholinergic drug scale as measures of anticholinergic exposure in older people in New Zealand: a population-level study. Drugs and Aging, 30(11), 927-934. [More Information]
  • Gnjidic, D., Hilmer, S. (2013). Discontinuation of risperidone in Alzheimer's disease. The New England Journal of Medicine, 368(2), 186-186. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2013). Discontinuation of statins in routine care settings. Annals of Internal Medicine, 159(1), 73-74. [More Information]
  • Gnjidic, D., Le Couteur, D., Pearson, S., McLachlan, A., Viney, R., Hilmer, S., Blyth, F., Joshy, G., Banks, E. (2013). High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health, 13, 1-9. [More Information]
  • Best, O., Gnjidic, D., Hilmer, S., Naganathan, V., McLachlan, A. (2013). Investigating polypharmacy and drug burden index in hospitalised older people. Internal Medicine Journal, 43(8), 912-918. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Letter: Rethinking psychotropics in nursing homes. Medical Journal of Australia, 199(2), 99-99. [More Information]
  • Bennett, A., Gnjidic, D., Hilmer, S. (2013). Medication exposure may confound the association between dietary intake and frailty. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 68(11), 1440-1440. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2013). Optimal cutoff of polypharmacy and outcomes - reply. Journal of Clinical Epidemiology, 66(4), 465-466. [More Information]
  • Johnston, C., Kirkpatrick, C., McLachlan, A., Hilmer, S. (2013). Physiologically Based Pharmacokinetic Modeling at the Extremes of Age. Clinical Pharmacology and Therapeutics, 93(2), 148-148. [More Information]
  • Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., et al (2013). Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review, 32(2), 218-222. [More Information]
  • Gnjidic, D., Bell, S., Hilmer, S. (2013). Re-evaluating psychotropic drug use across care settings. Journal of the American Geriatrics Society, 61(9), 1640-1641. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Rethinking psychotropics in nursing homes. Medical Journal of Australia. [More Information]
  • Nguyen, T., Hilmer, S., Cumming, R. (2013). Review of epidemiology and management of atrial fibrillation in developing countries. International Journal of Cardiology, 167(6), 2412-2420. [More Information]
  • Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013). Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open, 3(3), 1-10. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Statins in older adults. Australian Prescriber, 36(3), 79-82.
  • McCarthy, R., Hilmer, S. (2013). Teaching Junior Medical Officers safe and effective prescribing. Internal Medicine Journal, 43(11), 1250-1253. [More Information]
  • Gnjidic, D., Wilson, N., Hilmer, S. (2013). Understanding drug effects in older people: the role of pharmacology. JAMA Internal Medicine, 173(20), 1930. [More Information]

2012

  • Tannenbaum, C., Paquette, A., Hilmer, S., Holroyd-Leduc, J., Carnahan, R. (2012). A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs and Aging, 29(8), 639-658. [More Information]
  • Wilson, N., Hilmer, S., March, L., Chen, J., Gnjidic, D., Mason, R., Cameron, I., Sambrook, P. (2012). Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities. Drugs and Aging, 29(2), 157-165. [More Information]
  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Gnjidic, D., Le Couteur, D., Kouladjian, L., Hilmer, S. (2012). Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clinics in Geriatric Medicine, 28(2), 237-253. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2012). Drug Burden Index and Beers Criteria: Impact on Functional Outcomes in Older People Living in Self-Care Retirement Villages. The Journal of Clinical Pharmacology, 52(2), 258-265. [More Information]
  • Lonnroos, E., Gnjidic, D., Hilmer, S., Bell, J., Kautiaien, H., Sulkava, R., Hartikainen, S. (2012). Drug Burden Index and Hospitalization among Community-Dwelling Older People. Drugs and Aging, 29(5), 395-404. [More Information]
  • Gnjidic, D., Bell, S., Hilmer, S., Lonnroos, E., Sulkava, R., Hartikainen, S. (2012). Drug Burden Index associated with function in community-dwelling older people in Finland: A cross-sectional study. Annals of Medicine, 44(5), 458-467. [More Information]
  • Lowry, E., Woodman, R., Soiza, R., Hilmer, S., Mangoni, A. (2012). Drug burden index, physical function, and adverse outcomes in older hospitalized patients. Journal of Clinical Pharmacology, 52(10), 1584-1591. [More Information]
  • Gnjidic, D., Le Couteur, D., Naganathan, V., Cumming, R., Creasey, H., Waite, L., Sharma, A., Blyth, F., Hilmer, S. (2012). Effects of drug burden index on cognitive function in older men. Journal of Clinical Psychopharmacology, 32(2), 273-277. [More Information]
  • Gnjidic, D., Hilmer, S. (2012). Emergency hospitalizations for adverse drug events. The New England Journal of Medicine, 366(9), 859-859. [More Information]
  • Mitchell, S., Hilmer, S., Kirkpatrick, C., Hansen, R., Williamson, D., Singh, N., Finnegan, T., Allen, B., Diamond, T., Diwan, A., Lloyd, B., Smith, E., Fiatarone Singh, M. (2012). Estimation of lean body weight in older women with hip fracture. The Journal of Nutrition, Health and Aging, 16(2), 188-192. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology and Therapeutics, 91(3), 521-528. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2012). High-risk prescribing in older people: More harm than good? Aging Health, 8(4), 325-327. [More Information]
  • Bell, S., Le Couteur, D., McLachlan, A., Chen, T., Moles, R., Basger, B., Hilmer, S. (2012). Improving medicine selection for older people: Do we need an Australian classification for inappropriate medicines use? Australian Family Physician, 41(1/2), 9-10. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2012). Off-Label Use of Medicines: Time for Action. Clinical Pharmacology and Therapeutics, 92(2), 157-157. [More Information]
  • Hilmer, S., Gnjidic, D., Abernethy, D. (2012). Pharmacoepidemiology in the Postmarketing Assessment of the Safety and Efficacy of Drugs in Older Adults. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 181-188. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012). Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989-995. [More Information]
  • Gnjidic, D., Hilmer, S. (2012). POTENTIAL CONTRIBUTION OF MEDICATIONS TO FRAILTY. Journal of the American Geriatrics Society, 60(2), 401-401. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Hilmer, S., Gnjidic, D., Le Couteur, D. (2012). Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Australian Family Physician, 41(12), 924-928. [More Information]
  • McCarthy, R., Ogle, S., Finnegan, T., Hilmer, S. (2012). Which Aged Care inpatients are potentially suitable for community-based acute care? Australasian Journal on Ageing, 31(1), 56-59. [More Information]

2011

  • Johnston, C., Carroll, P., Matthews, S., Mitchell, S., Hilmer, S. (2011). 'You look like a 240 mg': Gentamicin dosing at a Sydney hospital. Journal of Pharmacy Practice and Research, 41(4), 275-277.
  • Mitchell, S., Kane, A., Hilmer, S. (2011). Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Current Gerontology and Geriatrics Research, 2011, 1-14. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Seibel, M., Mason, R., Chen, J., Cumming, R., Sambrook, P. (2011). Associations Between Drug Burden Index and Falls in Older People in Residential Aged Care. Journal of the American Geriatrics Society, 59(5), 875-880. [More Information]
  • McLachlan, A., Bath, S., Naganathan, V., Hilmer, S., Le Couteur, D., Gibson, S., Blyth, F. (2011). Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. British Journal of Clinical Pharmacology, 71(3), 351-364. [More Information]
  • Hardy, J., Hilmer, S. (2011). Deprescribing in the Last Year of Life. Journal of Pharmacy Practice and Research, 41(2), 146-151.
  • Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., et al (2011). Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178. [More Information]
  • Hilmer, S., Tran, K., Rubie, P., Wright, J., Gnjidic, D., Mitchell, S., Matthews, S., Carroll, P. (2011). Gentamicin Pharmacokinetics in Old Age and Frailty. British Journal of Clinical Pharmacology, 71(2), 224-231. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2011). Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Cogger, V., Hilmer, S., Svistounov, D. (2011). Mechanisms and implications of age-related changes in the liver. Current Gerontology and Geriatrics Research, 2011, 150364-150364. [More Information]
  • Hilmer, S., March, L., Sambrook, P., Wilson, N. (2011). Medication safety in residential aged-care facilities: a perspective. Therapeutic Advances in Drug Safety, 1(1), 11-20. [More Information]
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Mason, R., Sambrook, P. (2011). Physical functioning measures and risk of falling in older people living in residential aged care facilities. Therapeutic Advances in Musculoskeletal Disease, 3(1), 9-15. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2011). Reducing drugs in older adults is more. Archives of Internal Medicine, 171(9), 868-869. [More Information]
  • Wilson, N., Gnjidic, D., Hilmer, S. (2011). Safe Drug Use in Residential Aged Care Facilities. Geriatric Medicine in General Practice, 9, 6-8.
  • Wilson, N., Gnjidic, D., March, L., Sambrook, P., Hilmer, S. (2011). Use of PPIs Are Not Associated With Mortality in Institutionalized Older People. Archives of Internal Medicine, 171(9), 866-866. [More Information]

2010

  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2010). A Pilot Randomized Clinical Trial Utilizing the Drug Burden Index to Reduce Exposure to Anticholinergic and Sedative Medications in Older People. The Annals of Pharmacotherapy, 44(11), 1725-1732. [More Information]
  • Hilmer, S., Gnjidic, D. (2010). Adverse drug reactions in older people. Geriatric Medicine in General Practice, 4, 32-33.
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Seibel, M., Sambrook, P. (2010). Associations between drug burden index and physical function in older people in residential aged care facilities. Age and Ageing, 39(4), 503-507. [More Information]
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2010). Dosing Errors: Age-Related Changes in Pharmacokinetics. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 127-135). New York: Springer Science + Business Media.
  • Castelino, R., Hilmer, S., Bajorek, B., Nishtala, S., Chen, T. (2010). Drug Burden Index and potentially inappropriate medications in community-dwelling older people: the impact of Home Medicines Review. Drugs and Aging, 27(2), 135-148. [More Information]
  • Mitchell, S., Hilmer, S. (2010). Drug-Induced Liver Injury in Older Adults. Therapeutic Advances in Drug Safety, 1(2), 65-77. [More Information]
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
  • Perera, V., Hilmer, S., McLachlan, A. (2010). Frailty should be assessed using validated scales. Drugs and Aging, 27(8), 687. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2010). Hepatotoxicity of therapeutic short-course paracetamol inhospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335.
  • Joester, J., Vogler, C., Chang, K., Hilmer, S. (2010). Hypnosedative use and predictors of successful withdrawal in new patients attending a falls clinic: a retrospective, cohort study. Drugs and Aging, 27(11), 915-924. [More Information]
  • Wilson, N., March, L., Sambrook, P., Hilmer, S. (2010). Medication Safety in Residential Aged Care: a Perspective. Therapeutic Advances in Drug Safety, 1(1), 11-20. [More Information]
  • Gnjidic, D., Hilmer, S. (2010). Multiple medications and assessment of inappropriate medication use in older adults. Geriatric Medicine in General Practice, 6, 24-25.
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2010). Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. International Journal of Infectious Diseases, 14(10), e857-e867. [More Information]
  • Murnion, B., Gnjidic, D., Hilmer, S. (2010). Prescription and Administration of Opioids to Hospital In-patients, and Barriers to Effective Use. Pain Medicine, 11, 58-66. [More Information]
  • Ogle, S., Foster, K., Hilmer, S., Broadfoot, A., Thanh, H. (2010). Teaching Geriatric Medicine in Vietnam: Introduction of an interactive learning module for medical students. Australasian Journal on Ageing, 29(3). [More Information]
  • Gnjidic, D., Hilmer, S. (2010). Use of Potentially Inappropriate Medications in the Care of Frail Older People. Aging Health, 6(6), 705-716. [More Information]

2009

  • Boudreau, R., Hanlon, J., Roumani, Y., Studenski, S., Ruby, C., Wright, R., Hilmer, S., Shorr, R., Bauer, D., Simonsick, E., et al (2009). Central nervous system medication use and incident mobility limitation in community elders: the health, aging, and body composition study. Pharmacoepidemiology and Drug Safety: an international journal, 18(10), 916-922. [More Information]
  • Mitchell, S., Hilmer, S., McLachlan, A. (2009). Clinical pharmacology of analgesics in old age and frailty. Reviews in Clinical Gerontology, 19(2), 103-118. [More Information]
  • Mitchell, S., Murnion, B., Matthews, S., Hilmer, S. (2009). Compliance with Paracetamol Prescribing Policies at a Sydney Hospital. Journal of Pharmacy Practice and Research, 39(2), 122-127.
  • Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
  • Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009). Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology, 68(1), 97-105. [More Information]
  • Hilmer, S., Mager, D., Simonsick, E., Ling, S., Windham, G., Harris, T., Shorr, R., Bauer, D., Abernethy, D. (2009). Drug burden index score and functional decline in older people. The American Journal of Medicine, 122(12), 1142-1149. [More Information]
  • Wright, R., Roumani, Y., Boudreau, R., Newman, A., Ruby, C., Studenski, S., Shorr, R., Bauer, D., Simonsick, E., Hilmer, S., et al (2009). Effect of Central Nervous System Medication Use on Decline in Cognition in Community-Dwelling Older Adults: Findings from the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society, 57(2), 243-250. [More Information]
  • Hilmer, S., Ford, G. (2009). General Principals of Pharmacology. In J. Halter, J. Ouslander, M. Tinetti, S. Studenski, K. High, S. Asthana (Eds.), Hazzard’s Principles of Geriatric Medicine and Gerontology (6th ed), (pp. 103-122). United States of America: McGraw Hill.
  • Nishtala, S., Hilmer, S., McLachlan, A., Hannan, P., Chen, T. (2009). Impact of Residential Medication Management Reviews on Drug Burden Index in Aged-Care Homes - A Retrospective Analysis. Drugs and Aging, 26(8), 677-686. [More Information]
  • Hanlon, J., Boudreau, R., Roumani, Y., Newman, A., Ruby, C., Wright, R., Hilmer, S., Shorr, R., Bauer, D., Simonsick, E., et al (2009). Number and Dosage of Central Nervous System Medications on Recurrent Falls in Community Elders: The Health, Aging and Body Composition Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 64A(4), 492-498. [More Information]
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2009). Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. Pathology, 41(7), 615-621. [More Information]
  • Hilmer, S., Perera, V., Mitchell, S., Murnion, B., Dent, J., Bajorek, B., Matthews, S., Rolfson, D. (2009). The assessment of frailty in older people in acute care. Australasian Journal on Ageing, 28(4), 182-188. [More Information]
  • Hilmer, S., Gnjidic, D. (2009). The effects of polypharmacy in older adults. Clinical Pharmacology and Therapeutics, 85(1), 86-8. [More Information]
  • Perera, V., Bajorek, B., Matthews, S., Hilmer, S. (2009). The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age and Ageing, 38(2), 156-162. [More Information]
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2009). Variability in response to medicines in older people: Phenotypic and genotypic factors. Clinical Pharmacology and Therapeutics, 85(4), 431-433. [More Information]
  • Mitchell, S., Hilmer, S. (2009). What dose? Pharmacokinetic and pharmacodynamic changes in ageing and frailty. Geriatric Medicine in General Practice, 3, 30-31.

2008

  • Hilmer, S. (2008). ADME-tox issues for the elderly. Expert Opinion on Drug Metabolism and Toxicology, 4(10), 1321-1331. [More Information]
  • Gnjidic, D., Murnion, B., Hilmer, S. (2008). Age and opioid analgesia in an acute hospital population. Age and Ageing, 37(6), 699-702. [More Information]
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
  • Hilmer, S., Abernethy, D. (2008). Measures of drug toxicity in older adults. Archives of Internal Medicine, 168(17), 1930-1931. [More Information]
  • Cao, Y., Mager, D., Simonsick, E., Hilmer, S., Ling, S., Windham, B., Crentsil, V., Yasar, S., Fried, L., Abernethy, D. (2008). Physical and Cognitive Performance and Burden of Anticholinergics, Sedatives, and ACE Inhibitors in Older Women. Pharmacology and Therapeutics, 83(3), 422-429. [More Information]
  • Cheluvappa, R., Shimmon, R., Dawson, M., Hilmer, S., Le Couteur, D. (2008). Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochimica Polonica, 55(3), 571-580. [More Information]

2007

  • Hilmer, S., Mager, D., Simonsick, E., Cao, Y., Ling, S., Windham, G., Harris, T., Hanlon, J., Rubin, S., Shorr, R., et al (2007). A drug burden index to define the functional burden of medications in older people. Archives of Internal Medicine, 167(8), 781-787. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia: clinical and experimental diabetes and metabolism, 50(9), 1969-1976. [More Information]
  • Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Hilmer, S., McLachlan, A., Le Couteur, D. (2007). Clinical pharmacology in the geriatric patient. Fundamental and Clinical Pharmacology, 21(3), 217-230. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. New York Academy of Sciences. Annals, 1114, 88-92. [More Information]
  • Hilmer, S., Rangiah, C., Bajorek, B., Shenfield, G. (2007). Failure to weigh patients in hospital: a medication safety risk. Internal Medicine Journal, 37(9), 647-650. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]

2006

  • Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.
  • Lopez-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M., Allard, J., Ingram, D., Navas, P., et al (2006). Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 103(6), 1768-1773.
  • Everitt, A., Hilmer, S., Brand-Miller, J., Jamieson, H., Truswell, A., Sharma, A., Mason, R., Morris, B., Le Couteur, D. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1(1), 11-31.
  • Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
  • Hilmer, S., Heap, T., Eckstein, R., Lauer, C. (2006). Microscopic colitis associated with exposure to lansoprazole. Medical Journal of Australia, 184(4), 185-6. [More Information]

2005

  • Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
  • Hilmer, S., Seale, J. (2005). Alternatives to injectable opioids for acute analgesia. Medicine Today, 6, 39-47.
  • Everitt, A., Roth, G., Le Couteur, D., Hilmer, S. (2005). Calorie restriction versus drug therapy to delay the onset of ageing diseases and extend life. Age, 27(1), 39-48. [More Information]
  • Hilmer, S., Shenfield, G., Le Couteur, D. (2005). Clinical Implications of Changes in Hepatic Drug Metabolism in Older People. Therapeutics and Clinical Risk Management, 1(2), 151-156.
  • Le Couteur, D., Fraser, R., Hilmer, S., Rivory, L., McLean, A. (2005). The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clinical Pharmacokinetics, 44(2), 187-200. [More Information]

2004

  • Cumming, R., Glasgow, N., Le Couteur, D., Naganathan, V., Hilmer, S. (2004). Prescribing In Older People. Australian Family Physician, 33(10), 777-781.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799.

2003

  • Hilmer, S., Naganathan, V., Le Couteur, D. (2003). Why do physicians choose to train in geriatric medicine? Australasian Journal on Ageing, 11(3), 160-162.

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