Professor Sarah Hilmer

Conjoint Professor of Geriatric Pharmacology
Medicine, Northern Clinical School

Telephone +61 2 9926 7632
Fax +61 2 9926 7614

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Keywords

Ageing; Pharmacology

Clinical Specialty

Gerontology

Selected grants

2014

  • Agreement with the Agency for Clinical Innovation for the project Minimising the functional burden of medications in older patients: Implementation of the Drug Burden Index with A/Prof Sarah Hilmer.; Hilmer S; Agency for Clinical Innovation (ACI)/Collaborative Research Agreement.

2013

  • A randomised controlled trial of deprescribing to optimise medical therapy for frail older people: the Opti-Med study; Hilmer S, Naganathan V, McLachlan A, Comans T, Etherton-Beer C, Potter K; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Insights from ageing and calorie restriction for the prevention and treatment of paracetamol hepatotoxicity; Hilmer S, Kane A, Le Couteur D, Cogger V; Australian Association of Gerontology/RM Gibson Research Grants.

2012

  • Drug Burden Index and association with adverse outcomes in community-dwelling people with alzheimers disease; Gnjidic D, Hilmer S; Alzheimers Australia Dementia Research Foundation/Rosemary Foundation Travel Grant.
  • Seeding Research project; Hilmer S; Northern Sydney Local Health District/Research Support.
  • High risk prescribing in older Australians; Banks E, Le Couteur D, Pearson S, McLachlan A, Viney R, Hilmer S, Gnjidic D, Blyth F; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • The increasing burden of stroke with ageing: using CARAT to optimise preventative treatment in the community; Bajorek B, Krass I, Hilmer S, Magin P; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Drug Induced Liver Disease (DILD) in Old Age: understanding age-related suceptibility and pathogenesis; Hilmer S; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Ageing, Werner syndrome and Pseudocapillarization; Le Couteur D, Cogger V, Lebel M, Quinn R, Hilmer S, McCuskey R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Effects of aging on Hepatic Drug Clearance and Mechanisms of Drug Induced Liver Disease; Hilmer S, Jones B, Cogger V, De Cabo R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Optimising pain management in frail older people; McLachlan A, Naganathan V, Le Couteur D, Hilmer S, Gibson S; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Caloric restriction, ageing and the liver sinusoidal endothelium: mechanisms and implications; Le Couteur D, De Cabo R, De Cabo R, Cogger V, Hilmer S, Frazer R; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Research into the ageing liver; Hilmer S; Royal Australasian College of Surgeons/Sir Roy McCaughey Surgical Research Scholarship.

Selected publications

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Book Chapters

  • Hilmer, S., Gnjidic, D. (2014). Frailty. In Gideon Kaplan (Eds.), Geriatric Medicine: An Introduction, (pp. 189-201). Melbourne: IP Communications.
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2010). Dosing Errors: Age-Related Changes in Pharmacokinetics. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 127-135). New York: Springer Science+Business Media.
  • Hilmer, S., Ford, G. (2009). General Principals of Pharmacology. In J. Halter, J. Ouslander, M. Tinetti, S. Studenski, K. High, S. Asthana (Eds.), Hazzard's Principles of Geriatric Medicine and Gerontology, (pp. 103-122). New York, United States of America: McGraw Hill.
  • Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.

Journals

  • Nishtala, P., Gnjidic, D., Jamieson, H., Hanger, C., Kaluarachchi, C., Hilmer, S. (2016). 'Real-world' haemorrhagic rates for warfarin and dabigatran using population-level data in New Zealand. International Journal of Cardiology, 203, 746-752. [More Information]
  • Jamsen, K., Ilomaki, J., Hilmer, S., Jokanovic, N., Tan, E., Bell, J. (2016). A systematic review of the statistical methods in prospective cohort studies investigating the effect of medications on cognition in older people. Research in Social and Administrative Pharmacy, 12(1), 20-28. [More Information]
  • Kane, A., Mitchell, S., Mach, J., Huizer-Pajkos, A., McKenzie, C., Jones, B., Cogger, V., Le Couteur, D., de Cabo, R., Hilmer, S. (2016). Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. Experimental Gerontology, 73, 95-106. [More Information]
  • Huizer-Pajkos, A., Kane, A., Howlett, S., Mach, J., Mitchell, S., De Cabo, R., Le Couteur, D., Hilmer, S. (2016). Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 71(5), 571-577. [More Information]
  • Nishtala, P., Salahudeen, M., Hilmer, S. (2016). Anticholinergics: theoretical and clinical overview. Expert opinion on drug safety, 15(6), 753-768. [More Information]
  • Nguyen, T., Cumming, R., Hilmer, S. (2016). Atrial fibrillation in older inpatients: are there any differences in clinical characteristics and pharmacological treatment between the frail and the non-frail? Internal Medicine Journal, 46(1), 86-95. [More Information]
  • Reeve, E., Low, L., Hilmer, S. (2016). Beliefs and attitudes of older adults and carers about deprescribing of medications: a qualitative focus group study. British Journal of General Practice, 66(649), e552-e560. [More Information]
  • Nishtala, P., Gnjidic, D., Chyou, T., Hilmer, S. (2016). Discontinuation of statins in a population of older New Zealanders with limited life expectancy. Internal Medicine Journal, 46(4), 493-496. [More Information]
  • Kouladjian-O'Donnell, L., Chen, T., Gnjidic, D., Hilmer, S. (2016). Education and Assessment of Pharmacists on the Use of the Drug Burden Index in Older Adults Using a Continuing Professional Development Education Method. American Journal of Pharmaceutical Education, 80(4), 1-7. [More Information]
  • Nguyen, T., Pepperell, D., Morel-Kopp, M., Cumming, R., Ward, C., Hilmer, S. (2016). Effect of Frailty and Age on Platelet Aggregation and Response to Aspirin in Older Patients with Atrial Fibrillation: A Pilot Study. Cardiology and Therapy, 5(1), 51-62. [More Information]
  • Jamsen, K., Bell, J., Hilmer, S., Kirkpatrick, N., Ilomaki, J., Le Couteur, D., Blyth, F., Handelsman, D., Waite, L., Naganathan, V., Cumming, R., Gnjidic, D. (2016). Effects of Changes in Number of Medications and Drug Burden Index Exposure on Transitions between Frailty States and Death: The Concord Health and Ageing in Men Project Cohort Study. Journal of the American Geriatrics Society, 64(1), 89-95. [More Information]
  • Hiltunen, H., Tan, E., Ilomaki, J., Hilmer, S., Visvanathan, R., Emery, T., Robson, L., Jones, M., Hartikainen, S., Bell, J. (2016). Factors associated with antidepressant use in residents with and without dementia in Australian aged care facilities. Therapeutic Advances in Drug Safety, 7(3), 79-88. [More Information]
  • Kouladjian-O'Donnell, L., Gnjidic, D., Reeve, E., Chen, T., Hilmer, S. (2016). Health Care Practitioners' Perspectives on Deprescribing Anticholinergic and Sedative Medications in Older Adults. The Annals of Pharmacotherapy, 50(8), 625-636. [More Information]
  • Kane, A., Hilmer, S., Boyer, D., Gavin, K., Nines, D., Howlett, S., De Cabo, R., Mitchell, S. (2016). Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 71(3), 333-339. [More Information]
  • Kane, A., Huizer-Pajkos, A., Mach, J., McKenzie, C., Mitchell, S., De Cabo, R., Jones, B., Cogger, V., Le Couteur, D., Hilmer, S. (2016). N-Acetyl Cysteine does not prevent liver toxicity from chronic low dose plus sub-acute high dose paracetamol exposure in young or old mice. Fundamental and Clinical Pharmacology, 30(3), 263-275. [More Information]
  • Le Couteur, D., McLachlan, A., Hilmer, S. (2016). Polypharmacy in older people: When should you deprescribe? Medicine Today, 7(6), 16-24.
  • Thai, M., Reeve, E., Hilmer, S., Qi, K., Pearson, S., Gnjidic, D. (2016). Prevalence of statin-drug interactions in older people: A systematic review. European Journal of Clinical Pharmacology, 72(5), 513-521. [More Information]
  • Hilmer, S., Le Couteur, D. (2016). Standardized, Multidisciplinary Approaches for the Study of Aging Biology and for Translation of Aging Interventions. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 71(4), 425-426. [More Information]
  • Hilmer, S. (2016). Strategies to reduce medication errors. Medicine Today, 7(7), 44-50.
  • Mach, J., Huizer-Pajkos, A., Mitchell, S., McKenzie, C., Phillips, L., Kane, A., Jones, B., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2016). The effect of aging on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundamental and Clinical Pharmacology, 30(1), 23-34. [More Information]
  • Nguyen, T., Cumming, R., Hilmer, S. (2016). The Impact of Frailty on Mortality, Length of Stay and Re-hospitalisation in Older Patients with Atrial Fibrillation. Heart, Lung and Circulation, 25(6), 551-557. [More Information]
  • Mohamad, M., Mitchell, S., Wu, L., White, M., Cordwell, S., Mach, J., Solon-Biet, S., Boyer, D., Nines, D., Das, A., Warren, A., Hilmer, S., Simpson, S., Le Couteur, D., Cogger, V., et al (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15, 706-715. [More Information]
  • Bajorek, B., Magin, P., Hilmer, S., Krass, I. (2016). Utilization of antithrombotic therapy for stroke prevention in atrial fibrillation: a cross-sectional baseline analysis in general practice. Journal Of Clinical Pharmacy And Therapeutics, 41(4), 432-440. [More Information]
  • Hilmer, S., Seale, J., Carroll, P. (2015). A comparison of medical and pharmacy students' knowledge and skills of pharmacology and pharmacotherapy. British Journal of Clinical Pharmacology, 79(6), 1028-1029. [More Information]
  • Nguyen, T., Cumming, R., Hilmer, S. (2015). A review of frailty in developing countries. The Journal of Nutrition, Health and Aging, 19(9), 941-946. [More Information]
  • Reeve, E., Gnjidic, D., Long, J., Hilmer, S. (2015). A systematic review of the emerging definition of 'deprescribing' with network analysis: Implications for future research and clinical practice. British Journal of Clinical Pharmacology, 80(6), 1254-1268. [More Information]
  • Tan, E., Visvanathan, R., Hilmer, S., Emery, T., Robson, L., Vitry, A., Hughes, J., Jones, M., Moawad, S., Ilomaki, J., et al (2015). Analgesic Use and Daytime Sleepiness in Residents With and Without Dementia in Residential Aged Care Facilities. Drugs & Aging, 32(12), 1045-1053. [More Information]
  • Parkinson, L., Magin, P., Thomson, A., Byles, J., Caughey, G., Etherton-Beer, C., Gnjidic, D., Hilmer, S., Thomas King, T., McCowan, C., et al (2015). Anticholinergic burden in older women: not seeing the wood for the trees? Medical Journal of Australia, 202(2), 91-95. [More Information]
  • Reeve, E., Bell, J., Hilmer, S. (2015). Barriers to optimising prescribing and deprescribing in older adults with dementia: A narrative review. Current Clinical Pharmacology, 10(3), 168-177.
  • Saji, S., Hilmer, S., Nishtala, P. (2015). Comparison of anticholinergic risk scales and associations with adverse health outcomes in older people. Journal of the American Geriatrics Society, 63(1), 85-90. [More Information]
  • Bajorek, B., Magin, P., Hilmer, S., Krass, I. (2015). Contemporary approaches to managing Atrial fibrillation: A survey of Australian general practitioners. The Australasian Medical Journal, 8(11), 357-367. [More Information]
  • Mehta, D., Short, J., Hilmer, S., Nicolazzo, J. (2015). Drug access to the central nervous system in Alzheimer's disease: preclinical and clinical insights. Pharmaceutical Research, 32(3), 819-839. [More Information]
  • Hilmer, S., MacPherson, R. (2015). Effects of food on pharmacokinetics of immediate release oral formulations of simple analgesics: Potential implications for drug use, safety and efficacy. British Journal of Clinical Pharmacology, 80(6), 1243-1244. [More Information]
  • Kane, A., Hilmer, S., Huizer-Pajkos, A., Mach, J., Nines, D., Boyer, D., Gavin, K., Mitchell, S., De Cabo, R. (2015). Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 70(6), 694-695. [More Information]
  • Kouladjian-O'Donnell, L., Chen, T., Hilmer, S. (2015). First do no harm: a real need to deprescribe in older patients. Medical Journal of Australia, 202(4), 178-179. [More Information]
  • Gnjidic, D., Bennett, A., Le Couteur, D., Blyth, F., Cumming, R., Waite, L., Handelsman, D., Naganathan, V., Matthews, S., Hilmer, S. (2015). Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study. International Journal of Cardiology, 192, 49-55. [More Information]
  • Gnjidic, D., Pearson, S., Hilmer, S., Basilakis, J., Schaffer, A., Blyth, F., Banks, E. (2015). Manual versus automated coding of free-text self-reported medication data in the 45 and Up Study: a validation study. Public Health Research and Practice, 25(2), 1-9. [More Information]
  • Qi, K., Reeve, E., Hilmer, S., Pearson, S., Matthews, S., Gnjidic, D. (2015). Older peoples' attitudes regarding polypharmacy, statin use and willingness to have statins deprescribed in Australia. International Journal of Clinical Pharmacy, 37(5), 949-957. [More Information]
  • Tan, E., Jokanovic, N., Koponen, M., Thomas, D., Hilmer, S., Bell, J. (2015). Prevalence of analgesic use and pain in people with and without dementia or cognitive impairment in aged care facilities: A systematic review and meta-analysis. Current Clinical Pharmacology, 10(3), 194-203.
  • Thai, M., Hilmer, S., Pearson, S., Reeve, E., Gnjidic, D. (2015). Prevalence of Potential and Clinically Relevant Statin–Drug Interactions in Frail and Robust Older Inpatients. Drugs and Aging, 32(10), 849-856. [More Information]
  • Scott, I., Hilmer, S., Reeve, E., Potter, K., Le Couteur, D., Rigby, D., Gnjidic, D., Del Mar, C., Roughead, E., Page, A., Jansen, J., et al (2015). Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Internal Medicine, 175(5), 827-834. [More Information]
  • Gnjidic, D., Naganathan, V., Freedman, S., Beer, C., McLachlan, A., Hilmer, S., Figtree, G. (2015). Statin therapy and cognition in older people: What is the evidence? Current Clinical Pharmacology, 10(3), 185-193.
  • Gnjidic, D., Wilson, N., March, L., Cumming, R., Cameron, I., Hilmer, S. (2015). Statin utilisation patterns in older Australians living in residential care: 1-year prevalence study. Internal Medicine Journal, 45(1), 106-109. [More Information]
  • Mach, J., Huizer-Pajkos, A., Kane, A., Jones, B., McKenzie, C., Mitchell, S., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2015). The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. Experimental Gerontology, 67, 54-61. [More Information]
  • Reeve, E., Gnjidic, D., Hilmer, S. (2015). The role of the OncPal deprescribing guideline in end-of-life care. Supportive Care in Cancer, 23(4), 899. [More Information]
  • Bajorek, B., Magin, P., Hilmer, S., Krass, I. (2014). A cluster-randomized controlled trial of a computerized antithrombotic risk assessment tool to optimize stroke prevention in general practice: a study protocol. BMC Health Services Research, 14, 1-9. [More Information]
  • Ilomaki, J., Gnjidic, D., Le Couteur, D., Bell, J., Blyth, F., Handelsman, D., Cumming, R., Seibel, M., Waite, L., Naganathan, V., Hilmer, S. (2014). Alcohol consumption and tobacco smoking among community-dwelling older Australian men: the Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 33(3), 185-192. [More Information]
  • Tan, E., Visvanathan, R., Hilmer, S., Vitry, A., Quirke, T., Emery, T., Robson, L., Shortt, T., Sheldrick, S., Lee, S., Reeve, E., Gnjidic, D., et al (2014). Analgesic use, pain and daytime sedation in people with and without dementia in aged care facilities: a cross-sectional, multisite, epidemiological study protocol. BMJ Open, 4(6), 1-6. [More Information]
  • Nishtala, P., Narayan, S., Wang, T., Hilmer, S. (2014). Associations of drug burden index with falls, general practitioner visits, and mortality in older people. Pharmacoepidemiology and drug safety, 23(7), 753-758. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2014). Discontinuing drug treatments. BMJ, 349, 1-2. [More Information]
  • Hilmer, S., Gnjidic, D., Abernethy, D. (2014). Drug Burden Index for international assessment of the functional burden of medications in older people. Journal of the American Geriatrics Society, 62(4), 791-792. [More Information]
  • Kouladjian-O'Donnell, L., Gnjidic, D., Chen, T., Mangoni, A., Hilmer, S. (2014). Drug Burden Index in older adults: theoretical and practical issues. Clinical Interventions in Aging, 9, 1503-1515. [More Information]
  • Gnjidic, D., Hilmer, S., Hartikainen, S., Tolppanen, A., Taipale, H., Koponen, M., Bell, J. (2014). Impact of High Risk Drug Use on Hospitalization and Mortality in Older People with and without Alzheimer’s Disease: A National Population Cohort Study. PloS One, 9(1), 1-8.
  • Kashyap, M., Belleville, S., Mulsant, B., Hilmer, S., Paquette, A., Tu, L., Tannenbaum, C. (2014). Methodological challenges in determining longitudinal associations between anticholinergic drug use and incident cognitive decline. Journal of the American Geriatrics Society, 62(2), 336-341. [More Information]
  • Kouladjian-O'Donnell, L., Gnjidic, D., Chen, T., Hilmer, S. (2014). Modifications to the Drug Burden Index Calculation May Limit Interpretation of its Association with Clinical Outcomes in Older Adults. Neurocritical Care, 21(2), 365-366. [More Information]
  • Gnjidic, D., Pearson, S., Hilmer, S. (2014). Optimizing the Impact of Drugs on Symptom Burden in Older PeopleWith Multimorbidity at the End of Life. JAMA Internal Medicine, 174(4), 636-637. [More Information]
  • Bennett, A., Gnjidic, D., Gillett, M., Carroll, P., Matthews, S., Johnell, K., Fastbom, J., Hilmer, S. (2014). Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: a prospective cohort study. Drugs and Aging, 31(3), 225-232. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Bell, J. (2014). Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology, 28(1), 10-19. [More Information]
  • Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
  • Johnston, C., Hilmer, S., McLachlan, A., Matthews, S., Carroll, P., Kirkpatrick, C. (2014). The impact of frailty on pharmacokinetics in older people: using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtration. European Journal of Clinical Pharmacology, 70(5), 549-555. [More Information]
  • Narayan, S., Hilmer, S., Horsburgh, S., Nishtala, P. (2013). Anticholinergic component of the drug burden index and the anticholinergic drug scale as measures of anticholinergic exposure in older people in New Zealand: a population-level study. Drugs and Aging, 30(11), 927-934. [More Information]
  • Gnjidic, D., Hilmer, S. (2013). Discontinuation of risperidone in Alzheimer's disease. The New England Journal of Medicine, 368(2), 186-186. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2013). Discontinuation of statins in routine care settings. Annals of Internal Medicine, 159(1), 73-74. [More Information]
  • Gnjidic, D., Le Couteur, D., Pearson, S., McLachlan, A., Viney, R., Hilmer, S., Blyth, F., Joshy, G., Banks, E. (2013). High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health, 13, 1-9. [More Information]
  • Best, O., Gnjidic, D., Hilmer, S., Naganathan, V., McLachlan, A. (2013). Investigating polypharmacy and drug burden index in hospitalised older people. Internal Medicine Journal, 43(8), 912-918. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Letter: Rethinking psychotropics in nursing homes. Medical Journal of Australia, 199(2), 99-99. [More Information]
  • Bennett, A., Gnjidic, D., Hilmer, S. (2013). Medication exposure may confound the association between dietary intake and frailty. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 68(11), 1440-1440. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2013). Optimal cutoff of polypharmacy and outcomes - reply. Journal of Clinical Epidemiology, 66(4), 465-466. [More Information]
  • Johnston, C., Kirkpatrick, C., McLachlan, A., Hilmer, S. (2013). Physiologically Based Pharmacokinetic Modeling at the Extremes of Age. Clinical Pharmacology & Therapeutics, 93(2), 148-148. [More Information]
  • Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., et al (2013). Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review, 32(2), 218-222. [More Information]
  • Gnjidic, D., Bell, S., Hilmer, S. (2013). Re-evaluating psychotropic drug use across care settings. Journal of the American Geriatrics Society, 61(9), 1640-1641. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Rethinking psychotropics in nursing homes. Medical Journal of Australia, 199(2), 98. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Rethinking psychotropics in nursing homes: While evidence supports psychotropic use in nursing homes in some scenarios, we use them too often, for too long, at doses too high and in dangerous combinations with other medications. Medical Journal of Australia, 198(2), 77-77.
  • Nguyen, T., Hilmer, S., Cumming, R. (2013). Review of epidemiology and management of atrial fibrillation in developing countries. International Journal of Cardiology, 167(6), 2412-2420. [More Information]
  • Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013). Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open, 3(3), 1-10. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Statins in older adults. Australian Prescriber, 36(3), 79-82.
  • McCarthy, R., Hilmer, S. (2013). Teaching Junior Medical Officers safe and effective prescribing. Internal Medicine Journal, 43(11), 1250-1253. [More Information]
  • Gnjidic, D., Wilson, N., Hilmer, S. (2013). Understanding drug effects in older people: the role of pharmacology. JAMA Internal Medicine, 173(20), 1930. [More Information]
  • Tannenbaum, C., Paquette, A., Hilmer, S., Holroyd-Leduc, J., Carnahan, R. (2012). A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs and Aging, 29(8), 639-658. [More Information]
  • Wilson, N., Hilmer, S., March, L., Chen, J., Gnjidic, D., Mason, R., Cameron, I., Sambrook, P. (2012). Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities. Drugs and Aging, 29(2), 157-165. [More Information]
  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Gnjidic, D., Le Couteur, D., Kouladjian, L., Hilmer, S. (2012). Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clinics in Geriatric Medicine, 28(2), 237-253. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2012). Drug Burden Index and Beers Criteria: Impact on Functional Outcomes in Older People Living in Self-Care Retirement Villages. The Journal of Clinical Pharmacology, 52(2), 258-265. [More Information]
  • Lonnroos, E., Gnjidic, D., Hilmer, S., Bell, J., Kautiaien, H., Sulkava, R., Hartikainen, S. (2012). Drug Burden Index and Hospitalization among Community-Dwelling Older People. Drugs and Aging, 29(5), 395-404. [More Information]
  • Gnjidic, D., Bell, S., Hilmer, S., Lonnroos, E., Sulkava, R., Hartikainen, S. (2012). Drug Burden Index associated with function in community-dwelling older people in Finland: A cross-sectional study. Annals of Medicine, 44(5), 458-467. [More Information]
  • Lowry, E., Woodman, R., Soiza, R., Hilmer, S., Mangoni, A. (2012). Drug burden index, physical function, and adverse outcomes in older hospitalized patients. Journal of Clinical Pharmacology, 52(10), 1584-1591. [More Information]
  • Gnjidic, D., Le Couteur, D., Naganathan, V., Cumming, R., Creasey, H., Waite, L., Sharma, A., Blyth, F., Hilmer, S. (2012). Effects of drug burden index on cognitive function in older men. Journal of Clinical Psychopharmacology, 32(2), 273-277. [More Information]
  • Gnjidic, D., Hilmer, S. (2012). Emergency hospitalizations for adverse drug events. The New England Journal of Medicine, 366(9), 859-859. [More Information]
  • Mitchell, S., Hilmer, S., Kirkpatrick, C., Hansen, R., Williamson, D., Singh, N., Finnegan, T., Allen, B., Diamond, T., Diwan, A., Lloyd, B., Smith, E., Fiatarone Singh, M. (2012). Estimation of lean body weight in older women with hip fracture. The Journal of Nutrition, Health and Aging, 16(2), 188-192. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology & Therapeutics, 91(3), 521-528. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2012). High-risk prescribing in older people: More harm than good? Aging Health, 8(4), 325-327. [More Information]
  • Bell, S., Le Couteur, D., McLachlan, A., Chen, T., Moles, R., Basger, B., Hilmer, S. (2012). Improving medicine selection for older people: Do we need an Australian classification for inappropriate medicines use? Australian Family Physician, 41(1/2), 9-10. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2012). Off-Label Use of Medicines: Time for Action. Clinical Pharmacology & Therapeutics, 92(2), 157-157. [More Information]
  • Hilmer, S., Gnjidic, D., Abernethy, D. (2012). Pharmacoepidemiology in the Postmarketing Assessment of the Safety and Efficacy of Drugs in Older Adults. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 181-188. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012). Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989-995. [More Information]
  • Gnjidic, D., Hilmer, S. (2012). POTENTIAL CONTRIBUTION OF MEDICATIONS TO FRAILTY. Journal of the American Geriatrics Society, 60(2), 401-401. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Hilmer, S., Gnjidic, D., Le Couteur, D. (2012). Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Australian Family Physician, 41(12), 924-928. [More Information]
  • McCarthy, R., Ogle, S., Finnegan, T., Hilmer, S. (2012). Which Aged Care inpatients are potentially suitable for community-based acute care? Australasian Journal on Ageing, 31(1), 56-59. [More Information]
  • Johnston, C., Carroll, P., Matthews, S., Mitchell, S., Hilmer, S. (2011). 'You look like a 240 mg': Gentamicin dosing at a Sydney hospital. Journal of Pharmacy Practice and Research, 41(4), 275-277.
  • Mitchell, S., Kane, A., Hilmer, S. (2011). Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Current Gerontology and Geriatrics Research, 2011, 1-14. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Seibel, M., Mason, R., Chen, J., Cumming, R., Sambrook, P. (2011). Associations Between Drug Burden Index and Falls in Older People in Residential Aged Care. Journal of the American Geriatrics Society, 59(5), 875-880. [More Information]
  • McLachlan, A., Bath, S., Naganathan, V., Hilmer, S., Le Couteur, D., Gibson, S., Blyth, F. (2011). Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. British Journal of Clinical Pharmacology, 71(3), 351-364. [More Information]
  • Hardy, J., Hilmer, S. (2011). Deprescribing in the Last Year of Life. Journal of Pharmacy Practice and Research, 41(2), 146-151.
  • Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., et al (2011). Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178. [More Information]
  • Hilmer, S., Tran, K., Rubie, P., Wright, J., Gnjidic, D., Mitchell, S., Matthews, S., Carroll, P. (2011). Gentamicin Pharmacokinetics in Old Age and Frailty. British Journal of Clinical Pharmacology, 71(2), 224-231. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2011). Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Cogger, V., Hilmer, S., Svistounov, D. (2011). Mechanisms and implications of age-related changes in the liver. Current Gerontology and Geriatrics Research, 2011, 150364-150364. [More Information]
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Mason, R., Sambrook, P. (2011). Physical functioning measures and risk of falling in older people living in residential aged care facilities. Therapeutic Advances in Musculoskeletal Disease, 3(1), 9-15. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2011). Reducing drugs in older adults is more. Archives of Internal Medicine, 171(9), 868-869. [More Information]
  • Wilson, N., Gnjidic, D., Hilmer, S. (2011). Safe Drug Use in Residential Aged Care Facilities. Geriatric Medicine in General Practice, 9, 6-8.
  • Wilson, N., Gnjidic, D., March, L., Sambrook, P., Hilmer, S. (2011). Use of PPIs Are Not Associated With Mortality in Institutionalized Older People. Archives of Internal Medicine, 171(9), 866-866. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2010). A Pilot Randomized Clinical Trial Utilizing the Drug Burden Index to Reduce Exposure to Anticholinergic and Sedative Medications in Older People. The Annals of Pharmacotherapy, 44(11), 1725-1732. [More Information]
  • Hilmer, S., Gnjidic, D. (2010). Adverse drug reactions in older people. Geriatric Medicine in General Practice, 4, 32-33.
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Seibel, M., Sambrook, P. (2010). Associations between drug burden index and physical function in older people in residential aged care facilities. Age and Ageing, 39(4), 503-507. [More Information]
  • Castelino, R., Hilmer, S., Bajorek, B., Nishtala, S., Chen, T. (2010). Drug Burden Index and potentially inappropriate medications in community-dwelling older people: the impact of Home Medicines Review. Drugs and Aging, 27(2), 135-148. [More Information]
  • Mitchell, S., Hilmer, S. (2010). Drug-Induced Liver Injury in Older Adults. Therapeutic Advances in Drug Safety, 1(2), 65-77. [More Information]
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
  • Perera, V., Hilmer, S., McLachlan, A. (2010). Frailty should be assessed using validated scales. Drugs and Aging, 27(8), 687. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2010). Hepatotoxicity of therapeutic short-course paracetamol inhospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Joester, J., Vogler, C., Chang, K., Hilmer, S. (2010). Hypnosedative use and predictors of successful withdrawal in new patients attending a falls clinic: a retrospective, cohort study. Drugs and Aging, 27(11), 915-924. [More Information]
  • Wilson, N., March, L., Sambrook, P., Hilmer, S. (2010). Medication Safety in Residential Aged-Care Facilities: a Perspective. Therapeutic Advances in Drug Safety, 1(1), 11-20. [More Information]
  • Gnjidic, D., Hilmer, S. (2010). Multiple medications and assessment of inappropriate medication use in older adults. Geriatric Medicine in General Practice, 6, 24-25.
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2010). Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. International Journal of Infectious Diseases, 14(10), e857-e867. [More Information]
  • Murnion, B., Gnjidic, D., Hilmer, S. (2010). Prescription and Administration of Opioids to Hospital In-patients, and Barriers to Effective Use. Pain Medicine, 11, 58-66. [More Information]
  • Ogle, S., Foster, K., Hilmer, S., Broadfoot, A., Thanh, H. (2010). Teaching Geriatric Medicine in Vietnam: Introduction of an interactive learning module for medical students. Australasian Journal on Ageing, 29(3). [More Information]
  • Gnjidic, D., Hilmer, S. (2010). Use of Potentially Inappropriate Medications in the Care of Frail Older People. Aging Health, 6(6), 705-716. [More Information]
  • Boudreau, R., Hanlon, J., Roumani, Y., Studenski, S., Ruby, C., Wright, R., Hilmer, S., Shorr, R., Bauer, D., Simonsick, E., et al (2009). Central nervous system medication use and incident mobility limitation in community elders: the health, aging, and body composition study. Pharmacoepidemiology and Drug Safety: an international journal, 18(10), 916-922. [More Information]
  • Mitchell, S., Hilmer, S., McLachlan, A. (2009). Clinical pharmacology of analgesics in old age and frailty. Reviews in Clinical Gerontology, 19(2), 103-118. [More Information]
  • Mitchell, S., Murnion, B., Matthews, S., Hilmer, S. (2009). Compliance with Paracetamol Prescribing Policies at a Sydney Hospital. Journal of Pharmacy Practice and Research, 39(2), 122-127.
  • Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
  • Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009). Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology, 68(1), 97-105. [More Information]
  • Hilmer, S., Mager, D., Simonsick, E., Ling, S., Windham, G., Harris, T., Shorr, R., Bauer, D., Abernethy, D. (2009). Drug burden index score and functional decline in older people. The American Journal of Medicine, 122(12), 1142-1149. [More Information]
  • Wright, R., Roumani, Y., Boudreau, R., Newman, A., Ruby, C., Studenski, S., Shorr, R., Bauer, D., Simonsick, E., Hilmer, S., et al (2009). Effect of Central Nervous System Medication Use on Decline in Cognition in Community-Dwelling Older Adults: Findings from the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society, 57(2), 243-250. [More Information]
  • Nishtala, S., Hilmer, S., McLachlan, A., Hannan, P., Chen, T. (2009). Impact of Residential Medication Management Reviews on Drug Burden Index in Aged-Care Homes - A Retrospective Analysis. Drugs and Aging, 26(8), 677-686. [More Information]
  • Hanlon, J., Boudreau, R., Roumani, Y., Newman, A., Ruby, C., Wright, R., Hilmer, S., Shorr, R., Bauer, D., Simonsick, E., et al (2009). Number and Dosage of Central Nervous System Medications on Recurrent Falls in Community Elders: The Health, Aging and Body Composition Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 64A(4), 492-498. [More Information]
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2009). Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. Pathology, 41(7), 615-621. [More Information]
  • Hilmer, S., Perera, V., Mitchell, S., Murnion, B., Dent, J., Bajorek, B., Matthews, S., Rolfson, D. (2009). The assessment of frailty in older people in acute care. Australasian Journal on Ageing, 28(4), 182-188. [More Information]
  • Hilmer, S., Gnjidic, D. (2009). The effects of polypharmacy in older adults. Clinical Pharmacology & Therapeutics, 85(1), 86-88.
  • Hilmer, S., Gnjidic, D. (2009). The effects of polypharmacy in older adults. Clinical Pharmacology & Therapeutics, 85(1), 86-8. [More Information]
  • Perera, V., Bajorek, B., Matthews, S., Hilmer, S. (2009). The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age and Ageing, 38(2), 156-162. [More Information]
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2009). Variability in response to medicines in older people: Phenotypic and genotypic factors. Clinical Pharmacology & Therapeutics, 85(4), 431-433. [More Information]
  • Mitchell, S., Hilmer, S. (2009). What dose? Pharmacokinetic and pharmacodynamic changes in ageing and frailty. Geriatric Medicine in General Practice, 3, 30-31.
  • Hilmer, S. (2008). ADME-tox issues for the elderly. Expert Opinion on Drug Metabolism and Toxicology, 4(10), 1321-1331. [More Information]
  • Gnjidic, D., Murnion, B., Hilmer, S. (2008). Age and opioid analgesia in an acute hospital population. Age and Ageing, 37(6), 699-702. [More Information]
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
  • Hilmer, S., Abernethy, D. (2008). Measures of drug toxicity in older adults. Archives of Internal Medicine, 168(17), 1930-1931. [More Information]
  • Cao, Y., Mager, D., Simonsick, E., Hilmer, S., Ling, S., Windham, B., Crentsil, V., Yasar, S., Fried, L., Abernethy, D. (2008). Physical and Cognitive Performance and Burden of Anticholinergics, Sedatives, and ACE Inhibitors in Older Women. Pharmacology and Therapeutics, 83(3), 422-429. [More Information]
  • Cheluvappa, R., Shimmon, R., Dawson, M., Hilmer, S., Le Couteur, D. (2008). Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochimica Polonica, 55(3), 571-580. [More Information]
  • Hilmer, S., Mager, D., Simonsick, E., Cao, Y., Ling, S., Windham, G., Harris, T., Hanlon, J., Rubin, S., Shorr, R., et al (2007). A drug burden index to define the functional burden of medications in older people. Archives of Internal Medicine, 167(8), 781-787. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50(9), 1969-1976. [More Information]
  • Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Hilmer, S., McLachlan, A., Le Couteur, D. (2007). Clinical pharmacology in the geriatric patient. Fundamental and Clinical Pharmacology, 21(3), 217-230. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. Annals of the New York Academy of Sciences, 1114, 88-92. [More Information]
  • Hilmer, S., Rangiah, C., Bajorek, B., Shenfield, G. (2007). Failure to weigh patients in hospital: a medication safety risk. Internal Medicine Journal, 37(9), 647-650. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]
  • Lopez-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M., Allard, J., Ingram, D., Navas, P., et al (2006). Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 103(6), 1768-1773.
  • Everitt, A., Hilmer, S., Brand-Miller, J., Jamieson, H., Truswell, A., Sharma, A., Mason, R., Morris, B., Le Couteur, D. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1(1), 11-31.
  • Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
  • Hilmer, S., Heap, T., Eckstein, R., Lauer, C. (2006). Microscopic colitis associated with exposure to lansoprazole. Medical Journal of Australia, 184(4), 185-6. [More Information]
  • Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
  • Hilmer, S., Seale, J. (2005). Alternatives to injectable opioids for acute analgesia. Medicine Today, 6, 39-47.
  • Everitt, A., Roth, G., Le Couteur, D., Hilmer, S. (2005). Calorie restriction versus drug therapy to delay the onset of ageing diseases and extend life. Age, 27(1), 39-48. [More Information]
  • Hilmer, S., Shenfield, G., Le Couteur, D. (2005). Clinical Implications of Changes in Hepatic Drug Metabolism in Older People. Therapeutics and Clinical Risk Management, 1(2), 151-156.
  • Le Couteur, D., Fraser, R., Hilmer, S., Rivory, L., McLean, A. (2005). The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clinical Pharmacokinetics, 44(2), 187-200. [More Information]
  • Cumming, R., Glasgow, N., Le Couteur, D., Naganathan, V., Hilmer, S. (2004). Prescribing In Older People. Australian Family Physician, 33(10), 777-781.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799.
  • Hilmer, S., Naganathan, V., Le Couteur, D. (2003). Why do physicians choose to train in geriatric medicine? Australasian Journal on Ageing, 11(3), 160-162.

2016

  • Nishtala, P., Gnjidic, D., Jamieson, H., Hanger, C., Kaluarachchi, C., Hilmer, S. (2016). 'Real-world' haemorrhagic rates for warfarin and dabigatran using population-level data in New Zealand. International Journal of Cardiology, 203, 746-752. [More Information]
  • Jamsen, K., Ilomaki, J., Hilmer, S., Jokanovic, N., Tan, E., Bell, J. (2016). A systematic review of the statistical methods in prospective cohort studies investigating the effect of medications on cognition in older people. Research in Social and Administrative Pharmacy, 12(1), 20-28. [More Information]
  • Kane, A., Mitchell, S., Mach, J., Huizer-Pajkos, A., McKenzie, C., Jones, B., Cogger, V., Le Couteur, D., de Cabo, R., Hilmer, S. (2016). Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. Experimental Gerontology, 73, 95-106. [More Information]
  • Huizer-Pajkos, A., Kane, A., Howlett, S., Mach, J., Mitchell, S., De Cabo, R., Le Couteur, D., Hilmer, S. (2016). Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 71(5), 571-577. [More Information]
  • Nishtala, P., Salahudeen, M., Hilmer, S. (2016). Anticholinergics: theoretical and clinical overview. Expert opinion on drug safety, 15(6), 753-768. [More Information]
  • Nguyen, T., Cumming, R., Hilmer, S. (2016). Atrial fibrillation in older inpatients: are there any differences in clinical characteristics and pharmacological treatment between the frail and the non-frail? Internal Medicine Journal, 46(1), 86-95. [More Information]
  • Reeve, E., Low, L., Hilmer, S. (2016). Beliefs and attitudes of older adults and carers about deprescribing of medications: a qualitative focus group study. British Journal of General Practice, 66(649), e552-e560. [More Information]
  • Nishtala, P., Gnjidic, D., Chyou, T., Hilmer, S. (2016). Discontinuation of statins in a population of older New Zealanders with limited life expectancy. Internal Medicine Journal, 46(4), 493-496. [More Information]
  • Kouladjian-O'Donnell, L., Chen, T., Gnjidic, D., Hilmer, S. (2016). Education and Assessment of Pharmacists on the Use of the Drug Burden Index in Older Adults Using a Continuing Professional Development Education Method. American Journal of Pharmaceutical Education, 80(4), 1-7. [More Information]
  • Nguyen, T., Pepperell, D., Morel-Kopp, M., Cumming, R., Ward, C., Hilmer, S. (2016). Effect of Frailty and Age on Platelet Aggregation and Response to Aspirin in Older Patients with Atrial Fibrillation: A Pilot Study. Cardiology and Therapy, 5(1), 51-62. [More Information]
  • Jamsen, K., Bell, J., Hilmer, S., Kirkpatrick, N., Ilomaki, J., Le Couteur, D., Blyth, F., Handelsman, D., Waite, L., Naganathan, V., Cumming, R., Gnjidic, D. (2016). Effects of Changes in Number of Medications and Drug Burden Index Exposure on Transitions between Frailty States and Death: The Concord Health and Ageing in Men Project Cohort Study. Journal of the American Geriatrics Society, 64(1), 89-95. [More Information]
  • Hiltunen, H., Tan, E., Ilomaki, J., Hilmer, S., Visvanathan, R., Emery, T., Robson, L., Jones, M., Hartikainen, S., Bell, J. (2016). Factors associated with antidepressant use in residents with and without dementia in Australian aged care facilities. Therapeutic Advances in Drug Safety, 7(3), 79-88. [More Information]
  • Kouladjian-O'Donnell, L., Gnjidic, D., Reeve, E., Chen, T., Hilmer, S. (2016). Health Care Practitioners' Perspectives on Deprescribing Anticholinergic and Sedative Medications in Older Adults. The Annals of Pharmacotherapy, 50(8), 625-636. [More Information]
  • Kane, A., Hilmer, S., Boyer, D., Gavin, K., Nines, D., Howlett, S., De Cabo, R., Mitchell, S. (2016). Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 71(3), 333-339. [More Information]
  • Kane, A., Huizer-Pajkos, A., Mach, J., McKenzie, C., Mitchell, S., De Cabo, R., Jones, B., Cogger, V., Le Couteur, D., Hilmer, S. (2016). N-Acetyl Cysteine does not prevent liver toxicity from chronic low dose plus sub-acute high dose paracetamol exposure in young or old mice. Fundamental and Clinical Pharmacology, 30(3), 263-275. [More Information]
  • Le Couteur, D., McLachlan, A., Hilmer, S. (2016). Polypharmacy in older people: When should you deprescribe? Medicine Today, 7(6), 16-24.
  • Thai, M., Reeve, E., Hilmer, S., Qi, K., Pearson, S., Gnjidic, D. (2016). Prevalence of statin-drug interactions in older people: A systematic review. European Journal of Clinical Pharmacology, 72(5), 513-521. [More Information]
  • Hilmer, S., Le Couteur, D. (2016). Standardized, Multidisciplinary Approaches for the Study of Aging Biology and for Translation of Aging Interventions. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 71(4), 425-426. [More Information]
  • Hilmer, S. (2016). Strategies to reduce medication errors. Medicine Today, 7(7), 44-50.
  • Mach, J., Huizer-Pajkos, A., Mitchell, S., McKenzie, C., Phillips, L., Kane, A., Jones, B., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2016). The effect of aging on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundamental and Clinical Pharmacology, 30(1), 23-34. [More Information]
  • Nguyen, T., Cumming, R., Hilmer, S. (2016). The Impact of Frailty on Mortality, Length of Stay and Re-hospitalisation in Older Patients with Atrial Fibrillation. Heart, Lung and Circulation, 25(6), 551-557. [More Information]
  • Mohamad, M., Mitchell, S., Wu, L., White, M., Cordwell, S., Mach, J., Solon-Biet, S., Boyer, D., Nines, D., Das, A., Warren, A., Hilmer, S., Simpson, S., Le Couteur, D., Cogger, V., et al (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15, 706-715. [More Information]
  • Bajorek, B., Magin, P., Hilmer, S., Krass, I. (2016). Utilization of antithrombotic therapy for stroke prevention in atrial fibrillation: a cross-sectional baseline analysis in general practice. Journal Of Clinical Pharmacy And Therapeutics, 41(4), 432-440. [More Information]

2015

  • Hilmer, S., Seale, J., Carroll, P. (2015). A comparison of medical and pharmacy students' knowledge and skills of pharmacology and pharmacotherapy. British Journal of Clinical Pharmacology, 79(6), 1028-1029. [More Information]
  • Nguyen, T., Cumming, R., Hilmer, S. (2015). A review of frailty in developing countries. The Journal of Nutrition, Health and Aging, 19(9), 941-946. [More Information]
  • Reeve, E., Gnjidic, D., Long, J., Hilmer, S. (2015). A systematic review of the emerging definition of 'deprescribing' with network analysis: Implications for future research and clinical practice. British Journal of Clinical Pharmacology, 80(6), 1254-1268. [More Information]
  • Tan, E., Visvanathan, R., Hilmer, S., Emery, T., Robson, L., Vitry, A., Hughes, J., Jones, M., Moawad, S., Ilomaki, J., et al (2015). Analgesic Use and Daytime Sleepiness in Residents With and Without Dementia in Residential Aged Care Facilities. Drugs & Aging, 32(12), 1045-1053. [More Information]
  • Parkinson, L., Magin, P., Thomson, A., Byles, J., Caughey, G., Etherton-Beer, C., Gnjidic, D., Hilmer, S., Thomas King, T., McCowan, C., et al (2015). Anticholinergic burden in older women: not seeing the wood for the trees? Medical Journal of Australia, 202(2), 91-95. [More Information]
  • Reeve, E., Bell, J., Hilmer, S. (2015). Barriers to optimising prescribing and deprescribing in older adults with dementia: A narrative review. Current Clinical Pharmacology, 10(3), 168-177.
  • Saji, S., Hilmer, S., Nishtala, P. (2015). Comparison of anticholinergic risk scales and associations with adverse health outcomes in older people. Journal of the American Geriatrics Society, 63(1), 85-90. [More Information]
  • Bajorek, B., Magin, P., Hilmer, S., Krass, I. (2015). Contemporary approaches to managing Atrial fibrillation: A survey of Australian general practitioners. The Australasian Medical Journal, 8(11), 357-367. [More Information]
  • Mehta, D., Short, J., Hilmer, S., Nicolazzo, J. (2015). Drug access to the central nervous system in Alzheimer's disease: preclinical and clinical insights. Pharmaceutical Research, 32(3), 819-839. [More Information]
  • Hilmer, S., MacPherson, R. (2015). Effects of food on pharmacokinetics of immediate release oral formulations of simple analgesics: Potential implications for drug use, safety and efficacy. British Journal of Clinical Pharmacology, 80(6), 1243-1244. [More Information]
  • Kane, A., Hilmer, S., Huizer-Pajkos, A., Mach, J., Nines, D., Boyer, D., Gavin, K., Mitchell, S., De Cabo, R. (2015). Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 70(6), 694-695. [More Information]
  • Kouladjian-O'Donnell, L., Chen, T., Hilmer, S. (2015). First do no harm: a real need to deprescribe in older patients. Medical Journal of Australia, 202(4), 178-179. [More Information]
  • Gnjidic, D., Bennett, A., Le Couteur, D., Blyth, F., Cumming, R., Waite, L., Handelsman, D., Naganathan, V., Matthews, S., Hilmer, S. (2015). Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study. International Journal of Cardiology, 192, 49-55. [More Information]
  • Gnjidic, D., Pearson, S., Hilmer, S., Basilakis, J., Schaffer, A., Blyth, F., Banks, E. (2015). Manual versus automated coding of free-text self-reported medication data in the 45 and Up Study: a validation study. Public Health Research and Practice, 25(2), 1-9. [More Information]
  • Qi, K., Reeve, E., Hilmer, S., Pearson, S., Matthews, S., Gnjidic, D. (2015). Older peoples' attitudes regarding polypharmacy, statin use and willingness to have statins deprescribed in Australia. International Journal of Clinical Pharmacy, 37(5), 949-957. [More Information]
  • Tan, E., Jokanovic, N., Koponen, M., Thomas, D., Hilmer, S., Bell, J. (2015). Prevalence of analgesic use and pain in people with and without dementia or cognitive impairment in aged care facilities: A systematic review and meta-analysis. Current Clinical Pharmacology, 10(3), 194-203.
  • Thai, M., Hilmer, S., Pearson, S., Reeve, E., Gnjidic, D. (2015). Prevalence of Potential and Clinically Relevant Statin–Drug Interactions in Frail and Robust Older Inpatients. Drugs and Aging, 32(10), 849-856. [More Information]
  • Scott, I., Hilmer, S., Reeve, E., Potter, K., Le Couteur, D., Rigby, D., Gnjidic, D., Del Mar, C., Roughead, E., Page, A., Jansen, J., et al (2015). Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Internal Medicine, 175(5), 827-834. [More Information]
  • Gnjidic, D., Naganathan, V., Freedman, S., Beer, C., McLachlan, A., Hilmer, S., Figtree, G. (2015). Statin therapy and cognition in older people: What is the evidence? Current Clinical Pharmacology, 10(3), 185-193.
  • Gnjidic, D., Wilson, N., March, L., Cumming, R., Cameron, I., Hilmer, S. (2015). Statin utilisation patterns in older Australians living in residential care: 1-year prevalence study. Internal Medicine Journal, 45(1), 106-109. [More Information]
  • Mach, J., Huizer-Pajkos, A., Kane, A., Jones, B., McKenzie, C., Mitchell, S., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2015). The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. Experimental Gerontology, 67, 54-61. [More Information]
  • Reeve, E., Gnjidic, D., Hilmer, S. (2015). The role of the OncPal deprescribing guideline in end-of-life care. Supportive Care in Cancer, 23(4), 899. [More Information]

2014

  • Bajorek, B., Magin, P., Hilmer, S., Krass, I. (2014). A cluster-randomized controlled trial of a computerized antithrombotic risk assessment tool to optimize stroke prevention in general practice: a study protocol. BMC Health Services Research, 14, 1-9. [More Information]
  • Ilomaki, J., Gnjidic, D., Le Couteur, D., Bell, J., Blyth, F., Handelsman, D., Cumming, R., Seibel, M., Waite, L., Naganathan, V., Hilmer, S. (2014). Alcohol consumption and tobacco smoking among community-dwelling older Australian men: the Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 33(3), 185-192. [More Information]
  • Tan, E., Visvanathan, R., Hilmer, S., Vitry, A., Quirke, T., Emery, T., Robson, L., Shortt, T., Sheldrick, S., Lee, S., Reeve, E., Gnjidic, D., et al (2014). Analgesic use, pain and daytime sedation in people with and without dementia in aged care facilities: a cross-sectional, multisite, epidemiological study protocol. BMJ Open, 4(6), 1-6. [More Information]
  • Nishtala, P., Narayan, S., Wang, T., Hilmer, S. (2014). Associations of drug burden index with falls, general practitioner visits, and mortality in older people. Pharmacoepidemiology and drug safety, 23(7), 753-758. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2014). Discontinuing drug treatments. BMJ, 349, 1-2. [More Information]
  • Hilmer, S., Gnjidic, D., Abernethy, D. (2014). Drug Burden Index for international assessment of the functional burden of medications in older people. Journal of the American Geriatrics Society, 62(4), 791-792. [More Information]
  • Kouladjian-O'Donnell, L., Gnjidic, D., Chen, T., Mangoni, A., Hilmer, S. (2014). Drug Burden Index in older adults: theoretical and practical issues. Clinical Interventions in Aging, 9, 1503-1515. [More Information]
  • Hilmer, S., Gnjidic, D. (2014). Frailty. In Gideon Kaplan (Eds.), Geriatric Medicine: An Introduction, (pp. 189-201). Melbourne: IP Communications.
  • Gnjidic, D., Hilmer, S., Hartikainen, S., Tolppanen, A., Taipale, H., Koponen, M., Bell, J. (2014). Impact of High Risk Drug Use on Hospitalization and Mortality in Older People with and without Alzheimer’s Disease: A National Population Cohort Study. PloS One, 9(1), 1-8.
  • Kashyap, M., Belleville, S., Mulsant, B., Hilmer, S., Paquette, A., Tu, L., Tannenbaum, C. (2014). Methodological challenges in determining longitudinal associations between anticholinergic drug use and incident cognitive decline. Journal of the American Geriatrics Society, 62(2), 336-341. [More Information]
  • Kouladjian-O'Donnell, L., Gnjidic, D., Chen, T., Hilmer, S. (2014). Modifications to the Drug Burden Index Calculation May Limit Interpretation of its Association with Clinical Outcomes in Older Adults. Neurocritical Care, 21(2), 365-366. [More Information]
  • Gnjidic, D., Pearson, S., Hilmer, S. (2014). Optimizing the Impact of Drugs on Symptom Burden in Older PeopleWith Multimorbidity at the End of Life. JAMA Internal Medicine, 174(4), 636-637. [More Information]
  • Bennett, A., Gnjidic, D., Gillett, M., Carroll, P., Matthews, S., Johnell, K., Fastbom, J., Hilmer, S. (2014). Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: a prospective cohort study. Drugs and Aging, 31(3), 225-232. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Bell, J. (2014). Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology, 28(1), 10-19. [More Information]
  • Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
  • Johnston, C., Hilmer, S., McLachlan, A., Matthews, S., Carroll, P., Kirkpatrick, C. (2014). The impact of frailty on pharmacokinetics in older people: using gentamicin population pharmacokinetic modeling to investigate changes in renal drug clearance by glomerular filtration. European Journal of Clinical Pharmacology, 70(5), 549-555. [More Information]

2013

  • Narayan, S., Hilmer, S., Horsburgh, S., Nishtala, P. (2013). Anticholinergic component of the drug burden index and the anticholinergic drug scale as measures of anticholinergic exposure in older people in New Zealand: a population-level study. Drugs and Aging, 30(11), 927-934. [More Information]
  • Gnjidic, D., Hilmer, S. (2013). Discontinuation of risperidone in Alzheimer's disease. The New England Journal of Medicine, 368(2), 186-186. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2013). Discontinuation of statins in routine care settings. Annals of Internal Medicine, 159(1), 73-74. [More Information]
  • Gnjidic, D., Le Couteur, D., Pearson, S., McLachlan, A., Viney, R., Hilmer, S., Blyth, F., Joshy, G., Banks, E. (2013). High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health, 13, 1-9. [More Information]
  • Best, O., Gnjidic, D., Hilmer, S., Naganathan, V., McLachlan, A. (2013). Investigating polypharmacy and drug burden index in hospitalised older people. Internal Medicine Journal, 43(8), 912-918. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Letter: Rethinking psychotropics in nursing homes. Medical Journal of Australia, 199(2), 99-99. [More Information]
  • Bennett, A., Gnjidic, D., Hilmer, S. (2013). Medication exposure may confound the association between dietary intake and frailty. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 68(11), 1440-1440. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2013). Optimal cutoff of polypharmacy and outcomes - reply. Journal of Clinical Epidemiology, 66(4), 465-466. [More Information]
  • Johnston, C., Kirkpatrick, C., McLachlan, A., Hilmer, S. (2013). Physiologically Based Pharmacokinetic Modeling at the Extremes of Age. Clinical Pharmacology & Therapeutics, 93(2), 148-148. [More Information]
  • Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., et al (2013). Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review, 32(2), 218-222. [More Information]
  • Gnjidic, D., Bell, S., Hilmer, S. (2013). Re-evaluating psychotropic drug use across care settings. Journal of the American Geriatrics Society, 61(9), 1640-1641. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Rethinking psychotropics in nursing homes. Medical Journal of Australia, 199(2), 98. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Rethinking psychotropics in nursing homes: While evidence supports psychotropic use in nursing homes in some scenarios, we use them too often, for too long, at doses too high and in dangerous combinations with other medications. Medical Journal of Australia, 198(2), 77-77.
  • Nguyen, T., Hilmer, S., Cumming, R. (2013). Review of epidemiology and management of atrial fibrillation in developing countries. International Journal of Cardiology, 167(6), 2412-2420. [More Information]
  • Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013). Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open, 3(3), 1-10. [More Information]
  • Hilmer, S., Gnjidic, D. (2013). Statins in older adults. Australian Prescriber, 36(3), 79-82.
  • McCarthy, R., Hilmer, S. (2013). Teaching Junior Medical Officers safe and effective prescribing. Internal Medicine Journal, 43(11), 1250-1253. [More Information]
  • Gnjidic, D., Wilson, N., Hilmer, S. (2013). Understanding drug effects in older people: the role of pharmacology. JAMA Internal Medicine, 173(20), 1930. [More Information]

2012

  • Tannenbaum, C., Paquette, A., Hilmer, S., Holroyd-Leduc, J., Carnahan, R. (2012). A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs and Aging, 29(8), 639-658. [More Information]
  • Wilson, N., Hilmer, S., March, L., Chen, J., Gnjidic, D., Mason, R., Cameron, I., Sambrook, P. (2012). Associations between Drug Burden Index and Mortality in Older People in Residential Aged Care Facilities. Drugs and Aging, 29(2), 157-165. [More Information]
  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Gnjidic, D., Le Couteur, D., Kouladjian, L., Hilmer, S. (2012). Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clinics in Geriatric Medicine, 28(2), 237-253. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2012). Drug Burden Index and Beers Criteria: Impact on Functional Outcomes in Older People Living in Self-Care Retirement Villages. The Journal of Clinical Pharmacology, 52(2), 258-265. [More Information]
  • Lonnroos, E., Gnjidic, D., Hilmer, S., Bell, J., Kautiaien, H., Sulkava, R., Hartikainen, S. (2012). Drug Burden Index and Hospitalization among Community-Dwelling Older People. Drugs and Aging, 29(5), 395-404. [More Information]
  • Gnjidic, D., Bell, S., Hilmer, S., Lonnroos, E., Sulkava, R., Hartikainen, S. (2012). Drug Burden Index associated with function in community-dwelling older people in Finland: A cross-sectional study. Annals of Medicine, 44(5), 458-467. [More Information]
  • Lowry, E., Woodman, R., Soiza, R., Hilmer, S., Mangoni, A. (2012). Drug burden index, physical function, and adverse outcomes in older hospitalized patients. Journal of Clinical Pharmacology, 52(10), 1584-1591. [More Information]
  • Gnjidic, D., Le Couteur, D., Naganathan, V., Cumming, R., Creasey, H., Waite, L., Sharma, A., Blyth, F., Hilmer, S. (2012). Effects of drug burden index on cognitive function in older men. Journal of Clinical Psychopharmacology, 32(2), 273-277. [More Information]
  • Gnjidic, D., Hilmer, S. (2012). Emergency hospitalizations for adverse drug events. The New England Journal of Medicine, 366(9), 859-859. [More Information]
  • Mitchell, S., Hilmer, S., Kirkpatrick, C., Hansen, R., Williamson, D., Singh, N., Finnegan, T., Allen, B., Diamond, T., Diwan, A., Lloyd, B., Smith, E., Fiatarone Singh, M. (2012). Estimation of lean body weight in older women with hip fracture. The Journal of Nutrition, Health and Aging, 16(2), 188-192. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology & Therapeutics, 91(3), 521-528. [More Information]
  • Gnjidic, D., Hilmer, S., Le Couteur, D. (2012). High-risk prescribing in older people: More harm than good? Aging Health, 8(4), 325-327. [More Information]
  • Bell, S., Le Couteur, D., McLachlan, A., Chen, T., Moles, R., Basger, B., Hilmer, S. (2012). Improving medicine selection for older people: Do we need an Australian classification for inappropriate medicines use? Australian Family Physician, 41(1/2), 9-10. [More Information]
  • Gnjidic, D., Le Couteur, D., Hilmer, S. (2012). Off-Label Use of Medicines: Time for Action. Clinical Pharmacology & Therapeutics, 92(2), 157-157. [More Information]
  • Hilmer, S., Gnjidic, D., Abernethy, D. (2012). Pharmacoepidemiology in the Postmarketing Assessment of the Safety and Efficacy of Drugs in Older Adults. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 181-188. [More Information]
  • Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012). Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989-995. [More Information]
  • Gnjidic, D., Hilmer, S. (2012). POTENTIAL CONTRIBUTION OF MEDICATIONS TO FRAILTY. Journal of the American Geriatrics Society, 60(2), 401-401. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
  • Hilmer, S., Gnjidic, D., Le Couteur, D. (2012). Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Australian Family Physician, 41(12), 924-928. [More Information]
  • McCarthy, R., Ogle, S., Finnegan, T., Hilmer, S. (2012). Which Aged Care inpatients are potentially suitable for community-based acute care? Australasian Journal on Ageing, 31(1), 56-59. [More Information]

2011

  • Johnston, C., Carroll, P., Matthews, S., Mitchell, S., Hilmer, S. (2011). 'You look like a 240 mg': Gentamicin dosing at a Sydney hospital. Journal of Pharmacy Practice and Research, 41(4), 275-277.
  • Mitchell, S., Kane, A., Hilmer, S. (2011). Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Current Gerontology and Geriatrics Research, 2011, 1-14. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Seibel, M., Mason, R., Chen, J., Cumming, R., Sambrook, P. (2011). Associations Between Drug Burden Index and Falls in Older People in Residential Aged Care. Journal of the American Geriatrics Society, 59(5), 875-880. [More Information]
  • McLachlan, A., Bath, S., Naganathan, V., Hilmer, S., Le Couteur, D., Gibson, S., Blyth, F. (2011). Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. British Journal of Clinical Pharmacology, 71(3), 351-364. [More Information]
  • Hardy, J., Hilmer, S. (2011). Deprescribing in the Last Year of Life. Journal of Pharmacy Practice and Research, 41(2), 146-151.
  • Sittironnarit, G., Ames, D., Bush, A., Faux, N., Flicker, L., Foster, J., Hilmer, S., Lautenschlager, N., Maruff, P., Masters, C., et al (2011). Effects of anticholinergic drugs on cognitive function in older Australians: results from the AIBL study. Dementia and Geriatric Cognitive Disorders, 31(3), 173-178. [More Information]
  • Hilmer, S., Tran, K., Rubie, P., Wright, J., Gnjidic, D., Mitchell, S., Matthews, S., Carroll, P. (2011). Gentamicin Pharmacokinetics in Old Age and Frailty. British Journal of Clinical Pharmacology, 71(2), 224-231. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2011). Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Cogger, V., Hilmer, S., Svistounov, D. (2011). Mechanisms and implications of age-related changes in the liver. Current Gerontology and Geriatrics Research, 2011, 150364-150364. [More Information]
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Mason, R., Sambrook, P. (2011). Physical functioning measures and risk of falling in older people living in residential aged care facilities. Therapeutic Advances in Musculoskeletal Disease, 3(1), 9-15. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2011). Reducing drugs in older adults is more. Archives of Internal Medicine, 171(9), 868-869. [More Information]
  • Wilson, N., Gnjidic, D., Hilmer, S. (2011). Safe Drug Use in Residential Aged Care Facilities. Geriatric Medicine in General Practice, 9, 6-8.
  • Wilson, N., Gnjidic, D., March, L., Sambrook, P., Hilmer, S. (2011). Use of PPIs Are Not Associated With Mortality in Institutionalized Older People. Archives of Internal Medicine, 171(9), 866-866. [More Information]

2010

  • Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2010). A Pilot Randomized Clinical Trial Utilizing the Drug Burden Index to Reduce Exposure to Anticholinergic and Sedative Medications in Older People. The Annals of Pharmacotherapy, 44(11), 1725-1732. [More Information]
  • Hilmer, S., Gnjidic, D. (2010). Adverse drug reactions in older people. Geriatric Medicine in General Practice, 4, 32-33.
  • Wilson, N., Hilmer, S., March, L., Cameron, I., Lord, S., Seibel, M., Sambrook, P. (2010). Associations between drug burden index and physical function in older people in residential aged care facilities. Age and Ageing, 39(4), 503-507. [More Information]
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2010). Dosing Errors: Age-Related Changes in Pharmacokinetics. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 127-135). New York: Springer Science+Business Media.
  • Castelino, R., Hilmer, S., Bajorek, B., Nishtala, S., Chen, T. (2010). Drug Burden Index and potentially inappropriate medications in community-dwelling older people: the impact of Home Medicines Review. Drugs and Aging, 27(2), 135-148. [More Information]
  • Mitchell, S., Hilmer, S. (2010). Drug-Induced Liver Injury in Older Adults. Therapeutic Advances in Drug Safety, 1(2), 65-77. [More Information]
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
  • Perera, V., Hilmer, S., McLachlan, A. (2010). Frailty should be assessed using validated scales. Drugs and Aging, 27(8), 687. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2010). Hepatotoxicity of therapeutic short-course paracetamol inhospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Joester, J., Vogler, C., Chang, K., Hilmer, S. (2010). Hypnosedative use and predictors of successful withdrawal in new patients attending a falls clinic: a retrospective, cohort study. Drugs and Aging, 27(11), 915-924. [More Information]
  • Wilson, N., March, L., Sambrook, P., Hilmer, S. (2010). Medication Safety in Residential Aged-Care Facilities: a Perspective. Therapeutic Advances in Drug Safety, 1(1), 11-20. [More Information]
  • Gnjidic, D., Hilmer, S. (2010). Multiple medications and assessment of inappropriate medication use in older adults. Geriatric Medicine in General Practice, 6, 24-25.
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2010). Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. International Journal of Infectious Diseases, 14(10), e857-e867. [More Information]
  • Murnion, B., Gnjidic, D., Hilmer, S. (2010). Prescription and Administration of Opioids to Hospital In-patients, and Barriers to Effective Use. Pain Medicine, 11, 58-66. [More Information]
  • Ogle, S., Foster, K., Hilmer, S., Broadfoot, A., Thanh, H. (2010). Teaching Geriatric Medicine in Vietnam: Introduction of an interactive learning module for medical students. Australasian Journal on Ageing, 29(3). [More Information]
  • Gnjidic, D., Hilmer, S. (2010). Use of Potentially Inappropriate Medications in the Care of Frail Older People. Aging Health, 6(6), 705-716. [More Information]

2009

  • Boudreau, R., Hanlon, J., Roumani, Y., Studenski, S., Ruby, C., Wright, R., Hilmer, S., Shorr, R., Bauer, D., Simonsick, E., et al (2009). Central nervous system medication use and incident mobility limitation in community elders: the health, aging, and body composition study. Pharmacoepidemiology and Drug Safety: an international journal, 18(10), 916-922. [More Information]
  • Mitchell, S., Hilmer, S., McLachlan, A. (2009). Clinical pharmacology of analgesics in old age and frailty. Reviews in Clinical Gerontology, 19(2), 103-118. [More Information]
  • Mitchell, S., Murnion, B., Matthews, S., Hilmer, S. (2009). Compliance with Paracetamol Prescribing Policies at a Sydney Hospital. Journal of Pharmacy Practice and Research, 39(2), 122-127.
  • Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
  • Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009). Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology, 68(1), 97-105. [More Information]
  • Hilmer, S., Mager, D., Simonsick, E., Ling, S., Windham, G., Harris, T., Shorr, R., Bauer, D., Abernethy, D. (2009). Drug burden index score and functional decline in older people. The American Journal of Medicine, 122(12), 1142-1149. [More Information]
  • Wright, R., Roumani, Y., Boudreau, R., Newman, A., Ruby, C., Studenski, S., Shorr, R., Bauer, D., Simonsick, E., Hilmer, S., et al (2009). Effect of Central Nervous System Medication Use on Decline in Cognition in Community-Dwelling Older Adults: Findings from the Health, Aging and Body Composition Study. Journal of the American Geriatrics Society, 57(2), 243-250. [More Information]
  • Hilmer, S., Ford, G. (2009). General Principals of Pharmacology. In J. Halter, J. Ouslander, M. Tinetti, S. Studenski, K. High, S. Asthana (Eds.), Hazzard's Principles of Geriatric Medicine and Gerontology, (pp. 103-122). New York, United States of America: McGraw Hill.
  • Nishtala, S., Hilmer, S., McLachlan, A., Hannan, P., Chen, T. (2009). Impact of Residential Medication Management Reviews on Drug Burden Index in Aged-Care Homes - A Retrospective Analysis. Drugs and Aging, 26(8), 677-686. [More Information]
  • Hanlon, J., Boudreau, R., Roumani, Y., Newman, A., Ruby, C., Wright, R., Hilmer, S., Shorr, R., Bauer, D., Simonsick, E., et al (2009). Number and Dosage of Central Nervous System Medications on Recurrent Falls in Community Elders: The Health, Aging and Body Composition Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 64A(4), 492-498. [More Information]
  • Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2009). Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. Pathology, 41(7), 615-621. [More Information]
  • Hilmer, S., Perera, V., Mitchell, S., Murnion, B., Dent, J., Bajorek, B., Matthews, S., Rolfson, D. (2009). The assessment of frailty in older people in acute care. Australasian Journal on Ageing, 28(4), 182-188. [More Information]
  • Hilmer, S., Gnjidic, D. (2009). The effects of polypharmacy in older adults. Clinical Pharmacology & Therapeutics, 85(1), 86-88.
  • Hilmer, S., Gnjidic, D. (2009). The effects of polypharmacy in older adults. Clinical Pharmacology & Therapeutics, 85(1), 86-8. [More Information]
  • Perera, V., Bajorek, B., Matthews, S., Hilmer, S. (2009). The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age and Ageing, 38(2), 156-162. [More Information]
  • McLachlan, A., Hilmer, S., Le Couteur, D. (2009). Variability in response to medicines in older people: Phenotypic and genotypic factors. Clinical Pharmacology & Therapeutics, 85(4), 431-433. [More Information]
  • Mitchell, S., Hilmer, S. (2009). What dose? Pharmacokinetic and pharmacodynamic changes in ageing and frailty. Geriatric Medicine in General Practice, 3, 30-31.

2008

  • Hilmer, S. (2008). ADME-tox issues for the elderly. Expert Opinion on Drug Metabolism and Toxicology, 4(10), 1321-1331. [More Information]
  • Gnjidic, D., Murnion, B., Hilmer, S. (2008). Age and opioid analgesia in an acute hospital population. Age and Ageing, 37(6), 699-702. [More Information]
  • Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
  • Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
  • Hilmer, S., Abernethy, D. (2008). Measures of drug toxicity in older adults. Archives of Internal Medicine, 168(17), 1930-1931. [More Information]
  • Cao, Y., Mager, D., Simonsick, E., Hilmer, S., Ling, S., Windham, B., Crentsil, V., Yasar, S., Fried, L., Abernethy, D. (2008). Physical and Cognitive Performance and Burden of Anticholinergics, Sedatives, and ACE Inhibitors in Older Women. Pharmacology and Therapeutics, 83(3), 422-429. [More Information]
  • Cheluvappa, R., Shimmon, R., Dawson, M., Hilmer, S., Le Couteur, D. (2008). Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochimica Polonica, 55(3), 571-580. [More Information]

2007

  • Hilmer, S., Mager, D., Simonsick, E., Cao, Y., Ling, S., Windham, G., Harris, T., Hanlon, J., Rubin, S., Shorr, R., et al (2007). A drug burden index to define the functional burden of medications in older people. Archives of Internal Medicine, 167(8), 781-787. [More Information]
  • Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50(9), 1969-1976. [More Information]
  • Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
  • Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
  • Hilmer, S., McLachlan, A., Le Couteur, D. (2007). Clinical pharmacology in the geriatric patient. Fundamental and Clinical Pharmacology, 21(3), 217-230. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. Annals of the New York Academy of Sciences, 1114, 88-92. [More Information]
  • Hilmer, S., Rangiah, C., Bajorek, B., Shenfield, G. (2007). Failure to weigh patients in hospital: a medication safety risk. Internal Medicine Journal, 37(9), 647-650. [More Information]
  • Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]

2006

  • Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.
  • Lopez-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M., Allard, J., Ingram, D., Navas, P., et al (2006). Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 103(6), 1768-1773.
  • Everitt, A., Hilmer, S., Brand-Miller, J., Jamieson, H., Truswell, A., Sharma, A., Mason, R., Morris, B., Le Couteur, D. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1(1), 11-31.
  • Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
  • Hilmer, S., Heap, T., Eckstein, R., Lauer, C. (2006). Microscopic colitis associated with exposure to lansoprazole. Medical Journal of Australia, 184(4), 185-6. [More Information]

2005

  • Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
  • Hilmer, S., Seale, J. (2005). Alternatives to injectable opioids for acute analgesia. Medicine Today, 6, 39-47.
  • Everitt, A., Roth, G., Le Couteur, D., Hilmer, S. (2005). Calorie restriction versus drug therapy to delay the onset of ageing diseases and extend life. Age, 27(1), 39-48. [More Information]
  • Hilmer, S., Shenfield, G., Le Couteur, D. (2005). Clinical Implications of Changes in Hepatic Drug Metabolism in Older People. Therapeutics and Clinical Risk Management, 1(2), 151-156.
  • Le Couteur, D., Fraser, R., Hilmer, S., Rivory, L., McLean, A. (2005). The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clinical Pharmacokinetics, 44(2), 187-200. [More Information]

2004

  • Cumming, R., Glasgow, N., Le Couteur, D., Naganathan, V., Hilmer, S. (2004). Prescribing In Older People. Australian Family Physician, 33(10), 777-781.
  • Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57.
  • Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799.

2003

  • Hilmer, S., Naganathan, V., Le Couteur, D. (2003). Why do physicians choose to train in geriatric medicine? Australasian Journal on Ageing, 11(3), 160-162.

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