Dr Sarah Mitchell

NHMRC Overseas Biomedical Training Fellow
Medicine, Northern Clinical School

Telephone +61 2 9926 4922

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Selected grants

2011

  • Effects of trans-resveratrol on diet induced obesity in non-human primates; Mitchell S; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Journals

  • Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
  • Mitchell, S., Martin-Montalvo, A., Mercken, E., Palacios, H., Ward, T., Abulwerdi, G., Minor, R., Vlasuk, G., Ellis, J., Sinclair, D., et al (2014). The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet. Cell Reports, 6(5), 836-843. [More Information]
  • Martin-Montalvo, A., Mercken, E., Mitchell, S., Palacios, H., Mote, P., Scheibye-Knudsen, M., Gomes, A., Ward, T., Minor, R., Blouin, M., et al (2013). Metformin improves healthspan and lifespan in mice. Nature Communications, 4, 1-8. [More Information]
  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Dallaire, A., Garand, C., Paquet, E., Mitchell, S., De Cabo, R., Simard, M., Lebel, M. (2012). Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging. Aging, 4(9), 636-647. [More Information]
  • Mitchell, S., Hilmer, S., Kirkpatrick, C., Hansen, R., Williamson, D., Singh, N., Finnegan, T., Allen, B., Diamond, T., Diwan, A., Lloyd, B., Smith, E., Fiatarone Singh, M. (2012). Estimation of lean body weight in older women with hip fracture. The Journal of Nutrition, Health and Aging, 16(2), 188-192. [More Information]
  • Ashrafian, H., Czibik, G., Bellahcene, M., Aksentijevic, D., Smith, A., Mitchell, S., Dodd, M., Kirwan, J., Byrne, J., Ludwig, C., et al (2012). Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway. Cell Metabolism, 15(3), 361-371. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
  • Mitchell, S., Kane, A., Hilmer, S. (2011). Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Current Gerontology and Geriatrics Research, 2011, 1-14. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • Hilmer, S., Tran, K., Rubie, P., Wright, J., Gnjidic, D., Mitchell, S., Matthews, S., Carroll, P. (2011). Gentamicin Pharmacokinetics in Old Age and Frailty. British Journal of Clinical Pharmacology, 71(2), 224-231. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2011). Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
  • Mitchell, S., Hilmer, S. (2010). Drug-Induced Liver Injury in Older Adults. Therapeutic Advances in Drug Safety, 1(2), 65-77. [More Information]
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2010). Hepatotoxicity of therapeutic short-course paracetamol inhospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Mitchell, S., Hilmer, S., McLachlan, A. (2009). Clinical pharmacology of analgesics in old age and frailty. Reviews in Clinical Gerontology, 19(2), 103-118. [More Information]
  • Mitchell, S., Murnion, B., Matthews, S., Hilmer, S. (2009). Compliance with Paracetamol Prescribing Policies at a Sydney Hospital. Journal of Pharmacy Practice and Research, 39(2), 122-127.
  • Hilmer, S., Perera, V., Mitchell, S., Murnion, B., Dent, J., Bajorek, B., Matthews, S., Rolfson, D. (2009). The assessment of frailty in older people in acute care. Australasian Journal on Ageing, 28(4), 182-188. [More Information]
  • Mitchell, S., Hilmer, S. (2009). What dose? Pharmacokinetic and pharmacodynamic changes in ageing and frailty. Geriatric Medicine in General Practice, 3, 30-31.

2014

  • Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
  • Mitchell, S., Martin-Montalvo, A., Mercken, E., Palacios, H., Ward, T., Abulwerdi, G., Minor, R., Vlasuk, G., Ellis, J., Sinclair, D., et al (2014). The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet. Cell Reports, 6(5), 836-843. [More Information]

2013

  • Martin-Montalvo, A., Mercken, E., Mitchell, S., Palacios, H., Mote, P., Scheibye-Knudsen, M., Gomes, A., Ward, T., Minor, R., Blouin, M., et al (2013). Metformin improves healthspan and lifespan in mice. Nature Communications, 4, 1-8. [More Information]

2012

  • Kane, A., Mitchell, S., Carroll, P., Matthews, S., Hilmer, S. (2012). Characteristics of older and younger patients with suspected paracetamol toxicity. Australasian Journal on Ageing, 31(3), 190-193. [More Information]
  • Dallaire, A., Garand, C., Paquet, E., Mitchell, S., De Cabo, R., Simard, M., Lebel, M. (2012). Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging. Aging, 4(9), 636-647. [More Information]
  • Mitchell, S., Hilmer, S., Kirkpatrick, C., Hansen, R., Williamson, D., Singh, N., Finnegan, T., Allen, B., Diamond, T., Diwan, A., Lloyd, B., Smith, E., Fiatarone Singh, M. (2012). Estimation of lean body weight in older women with hip fracture. The Journal of Nutrition, Health and Aging, 16(2), 188-192. [More Information]
  • Ashrafian, H., Czibik, G., Bellahcene, M., Aksentijevic, D., Smith, A., Mitchell, S., Dodd, M., Kirwan, J., Byrne, J., Ludwig, C., et al (2012). Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway. Cell Metabolism, 15(3), 361-371. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]

2011

  • Mitchell, S., Kane, A., Hilmer, S. (2011). Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Current Gerontology and Geriatrics Research, 2011, 1-14. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
  • Hilmer, S., Tran, K., Rubie, P., Wright, J., Gnjidic, D., Mitchell, S., Matthews, S., Carroll, P. (2011). Gentamicin Pharmacokinetics in Old Age and Frailty. British Journal of Clinical Pharmacology, 71(2), 224-231. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2011). Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]
  • Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]

2010

  • Mitchell, S., Hilmer, S. (2010). Drug-Induced Liver Injury in Older Adults. Therapeutic Advances in Drug Safety, 1(2), 65-77. [More Information]
  • Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
  • Mitchell, S., Hilmer, S., Murnion, B., Matthews, S. (2010). Hepatotoxicity of therapeutic short-course paracetamol inhospital inpatients: impact of ageing and frailty. Journal Of Clinical Pharmacy And Therapeutics, 36(3), 327-335. [More Information]

2009

  • Mitchell, S., Hilmer, S., McLachlan, A. (2009). Clinical pharmacology of analgesics in old age and frailty. Reviews in Clinical Gerontology, 19(2), 103-118. [More Information]
  • Mitchell, S., Murnion, B., Matthews, S., Hilmer, S. (2009). Compliance with Paracetamol Prescribing Policies at a Sydney Hospital. Journal of Pharmacy Practice and Research, 39(2), 122-127.
  • Hilmer, S., Perera, V., Mitchell, S., Murnion, B., Dent, J., Bajorek, B., Matthews, S., Rolfson, D. (2009). The assessment of frailty in older people in acute care. Australasian Journal on Ageing, 28(4), 182-188. [More Information]
  • Mitchell, S., Hilmer, S. (2009). What dose? Pharmacokinetic and pharmacodynamic changes in ageing and frailty. Geriatric Medicine in General Practice, 3, 30-31.

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