Associate Professor Scott Byrne

Associate Professor in Immunology
Medicine, Central Clinical School

Telephone +61 2 9351 7308
Fax +61 2 8627 1608

Map

Biographical details

A/Prof Scott Byrne is a senior academic in the Discipline of Infectious Diseases and Immunology. As Head of The Cellular Photoimmunology Group, A/Prof Byrne and his team are dedicated to understanding the cellular and molecular mechanisms by which sunlight manipulates the immune response. He has established an international reputation in the field of photoimmunology https://twitter.com/photoimmunologyand made numerous seminal contributions in this area, particularly his discovery that ultraviolet (UV) radiation activates a unique type of regulatory B cell. He uncovered a key role for platelet activating factor and serotonin in UV-BReg activation. This is allowing him to design novel intervention strategies aimed at altering BReg activation in the context of both skin cancer and a CNS-targeted autoimmune attack.

Research interests

Living on a sun-drenched planet has traditionally required adaption to and protection from the harmful effects of solar ultraviolet radiation. This has been, and continues to be, necessary to combat the rising incidence of skin cancer. However, emerging evidence supports a protective effect of sunlight against a range of diseases including asthma, depression, colitis, autoimmune diseases, liver inflammation, obesity, diabetes, and cardiovascular disease.

My laboratory is interested in the cellular and molecular mechanisms underlying sunlight-induced immune suppression and tolerance. Specifically, we are exploring how ultraviolet radiation from the sun activates regulatory pathways. Our ultimate aim is touncover the mechanisms by which sunlight mediates both harmful and beneficial health effects. By understanding and manipulating these processes, we believe this will enable us to live healthier lives under the Australian sun.

Teaching and supervision

I teach Immunology in the Faculty of Science and the Sydney Medical School. I am the coordinator of 4 units of study including:

Current projects

Leader; Charles Perkins Centre Research Node "Living Healthier Lives Under the Australian Sun"

Associations

President; Molecular and Experimental Pathology Society of Australasiahttp://www.mepsa.org

Treasurer; NSW Branch of the Australasian Society for Immunology (http://www.immunology.org.au)

Awards and honours

  • Asia & Oceania Society for Photobiology (AOSP) Award for Young Scientists; Taipei, Taiwan (2015)
  • Consensus Innovation Award; 
awarded to the University of Sydney team that designed, tested and implemented the X-Lab in the CPC Teaching and Research Hub (2014)
  • European Society for Photobiology (ESP) Young Investigator Award; Geneva, Switzerland (2011)
  • NSW Young Tall Poppy Science Award winner (2009)
  • ICB Nature Publications Group publication of the year (2008)

In the media

International links

Austria

(University of Graz) Prof Peter Wolf

Selected grants

2016

  • Sunlight Effects on the Immune System; Byrne S; DVC Research/Bridging Support Grant.

2015

  • The Sydney 1000 Cancer Project – Stage 1 Gastrointestinal Cancers Immunophenotyping Study; Charles (nee Slaviero) K, Clarke S, Diakos C, Pavlakis N, Engel A, Samra J, Gill A, Kneebone A, Fazekas de St Groth B, Hart D, Smith A, Byrne S, McGuire H, Vafaee F, King M; DVC Research/SPARC Implementation - Cancer.
  • Safety and biological efficacy of narrow-band UVB phototherapy in ALS; Vucic S, Byrne S, Stewart G, Fernandez Penas P, Booth D, McKay F, Menon P, Turner B; Motor Neurone Disease Research Institute of Australia/Grants in aid.

2014

  • Skin cancer prevention and treatment by targeting sunlight-activated regulatory B cells; Byrne S, Halliday G, Damian D; Cancer Council New South Wales/Research Project Grants.
  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan K, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Targeting CNS-Autoimmunity with Sunlight-Activated Immune Regulatory Cells; Byrne S, Halliday G, Grimbaldeston M; Multiple Sclerosis Research Australia/Investigator Project Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2011

  • The small animal bioimager; Halliday G, Hambley T, Zreiqat H, Richardson D, Holst J, Rasko J, Byrne S, Dong Q, Hong A, Lyons G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Using Sunlight-induced Regulatory B Cells to prevent and/or treat EAE: equipment purchase; Halliday G, Byrne S; Multiple Sclerosis Research Australia/Incubator Grant.

2010

  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas de St Groth B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.
  • autoMACS Pro Separator; Abendroth A, Britton W, Richardson D, King N, Halliday G, Pollard J, McMinn P, Bishop A, Triccas J, Wang M, Byrne S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • The role of migrating mast cells in activating regulatory populations and suppressing anti-tumour immune responses; Byrne S; Cancer Institute New South Wales/Research Support.

2007

  • The Role of Mast Cells in the initiation of anti-bacterial immune responses; Byrne S; Clive & Vera Ramaciotti Foundation/Clive & Vera Ramaciotti Fndtn.
  • The role of sunlight-induced regulatory B cells in the suppression of anti-tumour immune responses; Byrne S; University of Sydney/Cancer Research Fund.
  • The Role of Mast Cells in the Induction of Regulatory B cells following exposure to Immunosuppressive Sunlight; Byrne S; University of Sydney/Early Career Researcher.
  • The role of sunlight-induced regulatory B cells in the suppression of anti-tumour immune responses; Byrne S; Cancer Institute New South Wales/Research Innovation Grants.
  • 12 congress of the european society for photobiology - Bath September 2007; Byrne S; Ian Potter Foundation/Grants & Travel Grants.

2005

  • FACS Aria for the University of Sydney Flow Cytometry Facility; King N, Pollard J, Rasko J, Lovicu F, Bishop A, Bertolino P, Briscoe H, Gillies M, Madigan M, McAvoy J, Murphy C, Balcar V, Armour C, Hughes M, Reeve V, Christopherson R, Halliday G, Christie M, Pollock C, McCaughan G, Gorrell M, Dong Q, Abendroth A, Menzies S, Barnetson R, Byrne S, Hunt N, Hambly B, Cook D, Mason R, Day M, Black J; University of Sydney/Equipment Grant.

2004

  • Characterisation of the cellular changes induced by ultraviolet A radiation; Byrne S, Halliday G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of NKT cells in the suppression of anti-tumor immune responses; Byrne S; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

2003

  • The role of dentritic cells and the macrophages in the immunological destruction of skin tumours; Halliday G, Byrne S; Cure Cancer Australia Foundation/Research Support.

Selected publications

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Book Chapters

  • Byrne, S., Halliday, G. (2009). Sunlight induced immunosuppression: a role for inflammatory mediators in the induction of suppressor cells. In Charles B Taylor (Eds.), Immunosuppression: New Research, (pp. 185-207). US: Nova Science Publishers.

Journals

  • Schweintzger, N., Gruber-Wackernagel, A., Reginato, E., Bambach, I., Quehenberger, F., Byrne, S., Wolf, P. (2015). Levels and function of regulatory T cells in patients with polymorphic light eruption: Relation to photohardening. British Journal of Dermatology, 173(2), 519-526. [More Information]
  • Schweintzger, N., Bambach, I., Reginato, E., Mayer, G., Limon-Flores, A., Ullrich, S., Byrne, S., Wolf, P. (2015). Mast cells are required for phototolerance induction and scratching abatement. Experimental Dermatology, 24(7), 491-496. [More Information]
  • Wei, J., Kok, L., Byrne, S., Halliday, G. (2015). Photodamage: all signs lead to actinic keratosis and early squamous cell carcinoma. Current Problems in Dermatology, 46, 14-19. [More Information]
  • McDonald, D., Byrne, S., Payne, R. (2015). Synthetic self-adjuvanting glycopeptide cancer vaccines. Frontiers in Chemistry, 3(60), 1-8. [More Information]
  • Byrne, S., Hammond, K., Chan, C., Rogers, L., Beaugie, C., Rana, S., Marsh-Wakefield, F., Thurman, J., Halliday, G. (2015). The alternative complement component factor B regulates UV-induced oedema, systemic suppression of contact and delayed hypersensitivity, and mast cell infiltration into the skin. Photochemical & Photobiological Sciences, 14(4), 801-806. [More Information]
  • Lucas, R., Byrne, S., Correale, J., Ilschner, S., Hart, P. (2015). Ultraviolet radiation, vitamin D and multiple sclerosis. Neurodegenerative Disease Management, 5(5), 413-424. [More Information]
  • Byrne, S., Sarchio, S. (2014). AMD3100 protects from UV-induced skin cancer. OncoImmunology, 3(1), 1-3. [More Information]
  • Halliday, G., Byrne, S. (2014). An Unexpected Role: UVA-Induced Release of Nitric Oxide from Skin May Have Unexpected Health Benefits. Journal of Investigative Dermatology, 134(7), 1791-1794. [More Information]
  • Byrne, S. (2014). How much sunlight is enough? Photochemical & Photobiological Sciences, 13, 840-852. [More Information]
  • Hinton, T., Yeoman, P., Carvalho, L., Parisio, M., Day, M., Byrne, S., Bell, A., Donohoe, K., Radford, J., Tregloan, P., Poronnik, P., Goodyear, P. (2014). Participating in the communication of science: Identifying relationships between laboratory space designs and students' activities. International Journal of Innovation in Science and Mathematics Education, 22(5), 30-42.
  • Wolf, P., Gruber-Wackernagel, A., Bambach, I., Schmidbauer, U., Mayer, G., Absenger, M., Frohlich, E., Byrne, S. (2014). Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell number in the papillary dermis. Experimental Dermatology, 23, 424-448.
  • Gruber-Wackernagel, A., Byrne, S., Wolf, P. (2014). Polymorphous light eruption: Clinic aspects and pathogenesis. Dermatologic Clinics, 32(2), 315-334. [More Information]
  • Kaufman (nee Alexander), K., Mactier, S., Armstrong, N., Mallawaaratchy, D., Byrne, S., Haydu, L., Jakrot, V., Thompson, J., Mann, G., Scolyer, R., Christopherson, R. (2014). Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients. Clinical and Experimental Metastasis, 31, 407-421. [More Information]
  • McDonald, D., Wilkinson, B., Corcilius, L., Thaysen-Andersen, M., Byrne, S., Payne, R. (2014). Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates. Chemical Communications, 50(71), 10273-10276. [More Information]
  • Leighton, S., Kok, L., Halliday, G., Byrne, S. (2013). Inhibition of UV-induced uric acid production using Allopurinol prevents suppression of the contact hypersensitivity response. Experimental Dermatology, 22(3), 189-194. [More Information]
  • Sarchio, S., Scolyer, R., Beaugie, C., McDonald, D., Marsh-Wakefield, F., Halliday, G., Byrne, S. (2013). Pharmacologically antagonizing the CXCR4-CXCL12 chemokine pathway with AMD3100 inhibits sunlight-induced skin cancer. Journal of Investigative Dermatology, 134(4), 1091-1100. [More Information]
  • Wolf, P., Gruber-Wackernagel, A., Rinner, B., Griesbacher, A., Eberhard, K., Groselj-Strele, A., Mayer, G., Stauber, R., Byrne, S. (2013). Phototherapeutic hardening modulates systemic cytokine levels in patients with polymorphic light eruption. Photochemical & Photobiological Sciences, 12(1), 166-173. [More Information]
  • Sarchio, S., Kok, L., O'Sullivan, C., Halliday, G., Byrne, S. (2012). Dermal mast cells affect the development of sunlight-induced skin tumours. Experimental Dermatology, 21(4), 241-248. [More Information]
  • Gruber-Wackernagel, A., Obermayer-Pietsch, B., Byrne, S., Wolf, P. (2012). Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D3 that increase upon 311 nm UVB photohardening. Photochemical and Photobiological Sciences, 11(12), 1831-1836. [More Information]
  • Ullrich, S., Byrne, S. (2012). The Immunologic Revolution: Photoimmunology. Journal of Investigative Dermatology, 132(3 pt 2), 896-905. [More Information]
  • Halliday, G., Damian, D., Rana, S., Byrne, S. (2012). The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: Implications for autoimmunity. Journal of Dermatological Science, 66(3), 176-182. [More Information]
  • Gruber-Wackernagel, A., Heinemann, A., Konya, V., Byrne, S., Singh, T., Hofer, A., Legat, F., Wolf, P. (2011). Photohardening restores the impaired neutrophil responsiveness to chemoattractants leukotriene B4 and formyl-methionyl-leucyl-phenylalanin in patients with polymorphic light eruption. Experimental Dermatology, 20(6), 473-476. [More Information]
  • Gruber-Wackernagel, A., Bambach, I., Legat, F., Hofer, A., Byrne, S., Quehenberger, F., Wolf, P. (2011). Randomized double-blinded placebo-controlled intra-individual trial on topical treatment with a 1,25-di-hydroxyvitamin D3 analogue in polymorphic light eruption. British Journal of Dermatology, 165(1), 152-163. [More Information]
  • Byrne, S., Beaugie, C., O'Sullivan, C., Leighton, S., Halliday, G. (2011). The Immune-Modulating Cytokine and Endogenous Alarmin Interleukin-33 Is Upregulated in Skin Exposed to Inflammatory UVB Radiation. The American Journal of Pathology: cellular and molecular biology of disease, 179(1), 211-222. [More Information]
  • Halliday, G., Byrne, S., Damian, D. (2011). Ultraviolet A Radiation: Its Role in Immunosuppression and Carcinogenesis. Seminars in Cutaneous Medicine and Surgery, 30(4), 214-221. [More Information]
  • Tran, J., Pupovac, A., Taylor, R., Wiley, J., Byrne, S., Sluyter, R. (2010). Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors. Experimental Dermatology, 19(8), e151-e157. [More Information]
  • Wolf, P., Byrne, S., Gruber-Wackernagel, A. (2009). New insights into the mechanisms of polymorphic light eruption: resistance to ultraviolet radiation-induced immune suppression as an aetiological factor. Experimental Dermatology, 18(4), 350-356. [More Information]
  • Gruber-Wackernagel, A., Byrne, S., Wolf, P. (2009). Pathogenic mechanisms of polymorphic light eruption. Frontiers in Bioscience, 1(1), 341-354. [More Information]
  • Stapelberg, P., Williams, R., Byrne, S., Halliday, G. (2009). The Alternative Complement Pathway Seems to be a UVA Sensor that Leads to Systemic Immunosuppression. Journal of Investigative Dermatology, 129(11), 2694-2701. [More Information]
  • Fukunaga, A., Khaskhely, N., Sreevidya, C., Byrne, S., Ullrich, S. (2008). Dermal dendritic cells, and not langerhans cells, play an essential role in inducing an immune response. The Journal of Immunology, 180(5), 3057-3064. [More Information]
  • Byrne, S., Limon-Flores, A., Ullrich, S. (2008). Mast Cell Migration from the Skin to the Draining Lymph Nodes upon Ultraviolet Irradiation Represents a Key Step in the Induction of Immune Suppression. The Journal of Immunology, 180(7), 4648-4655. [More Information]
  • Byrne, S., Knox, M., Halliday, G. (2008). TGFbeta is responsible for skin tumour infiltration by macrophages enabling the tumours to escape immune destruction. Immunology and Cell Biology, 86(1), 92-97. [More Information]
  • Halliday, G., Norval, M., Byrne, S., Huang, X., Wolf, P. (2008). The effects of sunlight on the skin. Drug Discovery Today: Disease Mechanisms, 5(2), e201-e209. [More Information]
  • Rana, S., Byrne, S., MacDonald, L., Chan, C., Halliday, G. (2008). Ultraviolet B Suppresses Immunity by Inhibiting Effector and Memory T Cells. The American Journal of Pathology: cellular and molecular biology of disease, 172(4), 993-1004. [More Information]
  • Fukunaga, A., Khaskhley, N., Byrne, S., Ullrich, S. (2007). Platelet-activation factor is involved in Langerhans cell migration. Journal of Investigative Dermatology, 127(Supplement 1), S113 (abstract 675)-S113.
  • Matsumura, Y., Byrne, S., Nghiem, D., Miyahara, Y., Ullrich, S. (2006). A role for inflammatory mediators in the induction of immunoregulatory B cells. The Journal of Immunology, 177(7), 4810-4817. [More Information]
  • Wolf, P., Nghiem, D., Walterscheid, J., Byrne, S., Matsumura, Y., Matsumura, Y., Bucana, C., Ananthaswamy, H., Ullrich, S. (2006). Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. The American Journal of Pathology: cellular and molecular biology of disease, 169(3), 795-805. [More Information]
  • Wolf, P., Walterscheid, J., Byrne, S., Nghiem, D., Ananthaswamy, H., Ullrich, S. (2006). Serotonin: Systemic mediator of PUVA-induced immune suppression but not inflammation or apoptosis. Journal of Investigative Dermatology, 126(Supp 3), 70-70.
  • Byrne, S., Spinks, N., Halliday, G. (2006). The induction of immunity to a protein antigen using an adjuvant is significantly compromised by ultraviolet A radiation. Journal of Photochemistry and Photobiology B-Biology, 84(2), 128-134. [More Information]
  • Wolf, P., Byrne, S., Walterscheid, J., Kazimi, N., Ananthaswamy, H., Stephen, U. (2006). UVB and PUVA-induced immune suppression and inflammation in platelet-activating factor (PAF) receptor knock-out mice. Journal of Investigative Dermatology, 126(Supp 1), 136-136.
  • Byrne, S., Halliday, G. (2005). B cells activated in lymph nodes in response to ultraviolet irradiation or by interleukin-10 inhibit dendritic cell induction of immunity. Journal of Investigative Dermatology, 124(3), 570-578. [More Information]
  • Barnetson, R., Poon, T., Byrne, S., Halliday, G. (2005). Implication of immune protection factor on sunscreen development. Journal Of The American Academy Of Dermatology, 52(3 Supplement 2), AB9 (Ab# 156-02)-AB9.
  • Weber, F., Byrne, S., Le, S., Brown, D., Breit, S., Scolyer, R., Halliday, G. (2005). Transforming growth factor-b1 immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system. Cancer Immunology, Immunotherapy: other biological response modifications, 54(9), 898-906. [More Information]
  • Byrne, S., Ahmed, J., Halliday, G. (2005). Ultraviolet B but Not A Radiation Activates Suppressor B Cells in Draining Lymph Nodes. Photochemistry and Photobiology, 81(6), 1366-1370. [More Information]
  • Rana, S., MacDonald, L., Byrne, S., Halliday, G. (2005). Ultraviolet-B radiation inhibits local T cell activation and suppresses the development of memory T cells. Tissue Antigens: immune response genetics, 66(5), 522 (Abstract 492)-522.
  • Halliday, G., Byrne, S., Kuchel, J., Poon, T., Barnetson, R. (2004). The Suppression Of Immunity By Ultraviolet Radiation: Uva, Nitric Oxide And DNA Damage. Photochemical and Photobiological Sciences, 3(8), 736-740.
  • Byrne, S., Halliday, G. (2003). High levels of Fas ligand and MHC class II in the absence of CD80 or CD86 expression and a decreased CD4+ T cell infiltration, enables murine skin tumours to progress. Cancer Immunology, Immunotherapy: other biological response modifications, 52(6), 396-402.
  • Byrne, S., Halliday, G. (2003). Phagocytosis by dendritic cells rather than MHC IIhigh macrophages is associated with skin tumour regression. International Journal of Cancer, 106(5), 736-744. [More Information]
  • Gerzina, T., Worthington, R., Byrne, S., McMahon, C. (2003). Student use and perceptions of different learning aids in a problem-based learning (PBL) dentistry course. Journal of Dental Education, 67(6), 641-653.
  • Stapelberg, M., Halliday, G., Byrne, S. (2003). The role of UVA and UVB in the Modulation of Immunity: Cellular and Chemical Respsonses. Trends in Photochemistry and Photobiology, 10, 103-110.
  • Byrne, S., Halliday, G. (2002). Dendritic cells: making progress with tumour regression? Immunology and Cell Biology, 80(6), 520-530.
  • Halliday, G., Byrne, S. (2002). Ultraviolet A induces immunosuppression, protection or memory enhancement depending on dose, while ultraviolet B is immunosuppresive and tolerogenic over a large dose range. Journal of Photoscience, 9, 197-200.
  • Byrne, S., Spinks, N., Halliday, G. (2002). Ultraviolet A irradiation of C57BL/6 mice suppresses systemic contact hypersensitivity or enhances secondary immunity depending on dose. Journal of Investigative Dermatology, 119(4), 858-864.
  • Byrne, S. (2001). High numbers of infiltrating Langerhans cells in the absence of MHC IIhigh macrophages is associated with skin tumour regression. Journal of Investigative Dermatology, 117(4), 1009.
  • Byrne, S., Halliday, G., Johnston, L., King, N. (2001). Interleukin-1beta But not tumor necrosis factor is involved in West Nile Virus-Induced Langerhans Cell Migration from the Skin in C57BL/6 Mice. Journal of Investigative Dermatology, 117(3), 702-709.

Conferences

  • Byrne, S., Halliday, G. (2005). B cells activated in lymph nodes in response to ultraviolet-irradiation or by interleukin-10 inhibit dendritic cell induction of immunity. 2nd Annual Meeting of the Australasian-Society for Dermatology Research, United States: Blackwell Publishers.
  • Barnetson, R., Poon, T., Byrne, S., Halliday, G. (2005). Implication of immune protection factor on sunscreen development. 63rd Annual Meeting of the American Academy of Dermatology, United States: Mosby Inc.

2015

  • Schweintzger, N., Gruber-Wackernagel, A., Reginato, E., Bambach, I., Quehenberger, F., Byrne, S., Wolf, P. (2015). Levels and function of regulatory T cells in patients with polymorphic light eruption: Relation to photohardening. British Journal of Dermatology, 173(2), 519-526. [More Information]
  • Schweintzger, N., Bambach, I., Reginato, E., Mayer, G., Limon-Flores, A., Ullrich, S., Byrne, S., Wolf, P. (2015). Mast cells are required for phototolerance induction and scratching abatement. Experimental Dermatology, 24(7), 491-496. [More Information]
  • Wei, J., Kok, L., Byrne, S., Halliday, G. (2015). Photodamage: all signs lead to actinic keratosis and early squamous cell carcinoma. Current Problems in Dermatology, 46, 14-19. [More Information]
  • McDonald, D., Byrne, S., Payne, R. (2015). Synthetic self-adjuvanting glycopeptide cancer vaccines. Frontiers in Chemistry, 3(60), 1-8. [More Information]
  • Byrne, S., Hammond, K., Chan, C., Rogers, L., Beaugie, C., Rana, S., Marsh-Wakefield, F., Thurman, J., Halliday, G. (2015). The alternative complement component factor B regulates UV-induced oedema, systemic suppression of contact and delayed hypersensitivity, and mast cell infiltration into the skin. Photochemical & Photobiological Sciences, 14(4), 801-806. [More Information]
  • Lucas, R., Byrne, S., Correale, J., Ilschner, S., Hart, P. (2015). Ultraviolet radiation, vitamin D and multiple sclerosis. Neurodegenerative Disease Management, 5(5), 413-424. [More Information]

2014

  • Byrne, S., Sarchio, S. (2014). AMD3100 protects from UV-induced skin cancer. OncoImmunology, 3(1), 1-3. [More Information]
  • Halliday, G., Byrne, S. (2014). An Unexpected Role: UVA-Induced Release of Nitric Oxide from Skin May Have Unexpected Health Benefits. Journal of Investigative Dermatology, 134(7), 1791-1794. [More Information]
  • Byrne, S. (2014). How much sunlight is enough? Photochemical & Photobiological Sciences, 13, 840-852. [More Information]
  • Hinton, T., Yeoman, P., Carvalho, L., Parisio, M., Day, M., Byrne, S., Bell, A., Donohoe, K., Radford, J., Tregloan, P., Poronnik, P., Goodyear, P. (2014). Participating in the communication of science: Identifying relationships between laboratory space designs and students' activities. International Journal of Innovation in Science and Mathematics Education, 22(5), 30-42.
  • Wolf, P., Gruber-Wackernagel, A., Bambach, I., Schmidbauer, U., Mayer, G., Absenger, M., Frohlich, E., Byrne, S. (2014). Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell number in the papillary dermis. Experimental Dermatology, 23, 424-448.
  • Gruber-Wackernagel, A., Byrne, S., Wolf, P. (2014). Polymorphous light eruption: Clinic aspects and pathogenesis. Dermatologic Clinics, 32(2), 315-334. [More Information]
  • Kaufman (nee Alexander), K., Mactier, S., Armstrong, N., Mallawaaratchy, D., Byrne, S., Haydu, L., Jakrot, V., Thompson, J., Mann, G., Scolyer, R., Christopherson, R. (2014). Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients. Clinical and Experimental Metastasis, 31, 407-421. [More Information]
  • McDonald, D., Wilkinson, B., Corcilius, L., Thaysen-Andersen, M., Byrne, S., Payne, R. (2014). Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates. Chemical Communications, 50(71), 10273-10276. [More Information]

2013

  • Leighton, S., Kok, L., Halliday, G., Byrne, S. (2013). Inhibition of UV-induced uric acid production using Allopurinol prevents suppression of the contact hypersensitivity response. Experimental Dermatology, 22(3), 189-194. [More Information]
  • Sarchio, S., Scolyer, R., Beaugie, C., McDonald, D., Marsh-Wakefield, F., Halliday, G., Byrne, S. (2013). Pharmacologically antagonizing the CXCR4-CXCL12 chemokine pathway with AMD3100 inhibits sunlight-induced skin cancer. Journal of Investigative Dermatology, 134(4), 1091-1100. [More Information]
  • Wolf, P., Gruber-Wackernagel, A., Rinner, B., Griesbacher, A., Eberhard, K., Groselj-Strele, A., Mayer, G., Stauber, R., Byrne, S. (2013). Phototherapeutic hardening modulates systemic cytokine levels in patients with polymorphic light eruption. Photochemical & Photobiological Sciences, 12(1), 166-173. [More Information]

2012

  • Sarchio, S., Kok, L., O'Sullivan, C., Halliday, G., Byrne, S. (2012). Dermal mast cells affect the development of sunlight-induced skin tumours. Experimental Dermatology, 21(4), 241-248. [More Information]
  • Gruber-Wackernagel, A., Obermayer-Pietsch, B., Byrne, S., Wolf, P. (2012). Patients with polymorphic light eruption have decreased serum levels of 25-hydroxyvitamin-D3 that increase upon 311 nm UVB photohardening. Photochemical and Photobiological Sciences, 11(12), 1831-1836. [More Information]
  • Ullrich, S., Byrne, S. (2012). The Immunologic Revolution: Photoimmunology. Journal of Investigative Dermatology, 132(3 pt 2), 896-905. [More Information]
  • Halliday, G., Damian, D., Rana, S., Byrne, S. (2012). The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: Implications for autoimmunity. Journal of Dermatological Science, 66(3), 176-182. [More Information]

2011

  • Gruber-Wackernagel, A., Heinemann, A., Konya, V., Byrne, S., Singh, T., Hofer, A., Legat, F., Wolf, P. (2011). Photohardening restores the impaired neutrophil responsiveness to chemoattractants leukotriene B4 and formyl-methionyl-leucyl-phenylalanin in patients with polymorphic light eruption. Experimental Dermatology, 20(6), 473-476. [More Information]
  • Gruber-Wackernagel, A., Bambach, I., Legat, F., Hofer, A., Byrne, S., Quehenberger, F., Wolf, P. (2011). Randomized double-blinded placebo-controlled intra-individual trial on topical treatment with a 1,25-di-hydroxyvitamin D3 analogue in polymorphic light eruption. British Journal of Dermatology, 165(1), 152-163. [More Information]
  • Byrne, S., Beaugie, C., O'Sullivan, C., Leighton, S., Halliday, G. (2011). The Immune-Modulating Cytokine and Endogenous Alarmin Interleukin-33 Is Upregulated in Skin Exposed to Inflammatory UVB Radiation. The American Journal of Pathology: cellular and molecular biology of disease, 179(1), 211-222. [More Information]
  • Halliday, G., Byrne, S., Damian, D. (2011). Ultraviolet A Radiation: Its Role in Immunosuppression and Carcinogenesis. Seminars in Cutaneous Medicine and Surgery, 30(4), 214-221. [More Information]

2010

  • Tran, J., Pupovac, A., Taylor, R., Wiley, J., Byrne, S., Sluyter, R. (2010). Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors. Experimental Dermatology, 19(8), e151-e157. [More Information]

2009

  • Wolf, P., Byrne, S., Gruber-Wackernagel, A. (2009). New insights into the mechanisms of polymorphic light eruption: resistance to ultraviolet radiation-induced immune suppression as an aetiological factor. Experimental Dermatology, 18(4), 350-356. [More Information]
  • Gruber-Wackernagel, A., Byrne, S., Wolf, P. (2009). Pathogenic mechanisms of polymorphic light eruption. Frontiers in Bioscience, 1(1), 341-354. [More Information]
  • Byrne, S., Halliday, G. (2009). Sunlight induced immunosuppression: a role for inflammatory mediators in the induction of suppressor cells. In Charles B Taylor (Eds.), Immunosuppression: New Research, (pp. 185-207). US: Nova Science Publishers.
  • Stapelberg, P., Williams, R., Byrne, S., Halliday, G. (2009). The Alternative Complement Pathway Seems to be a UVA Sensor that Leads to Systemic Immunosuppression. Journal of Investigative Dermatology, 129(11), 2694-2701. [More Information]

2008

  • Fukunaga, A., Khaskhely, N., Sreevidya, C., Byrne, S., Ullrich, S. (2008). Dermal dendritic cells, and not langerhans cells, play an essential role in inducing an immune response. The Journal of Immunology, 180(5), 3057-3064. [More Information]
  • Byrne, S., Limon-Flores, A., Ullrich, S. (2008). Mast Cell Migration from the Skin to the Draining Lymph Nodes upon Ultraviolet Irradiation Represents a Key Step in the Induction of Immune Suppression. The Journal of Immunology, 180(7), 4648-4655. [More Information]
  • Byrne, S., Knox, M., Halliday, G. (2008). TGFbeta is responsible for skin tumour infiltration by macrophages enabling the tumours to escape immune destruction. Immunology and Cell Biology, 86(1), 92-97. [More Information]
  • Halliday, G., Norval, M., Byrne, S., Huang, X., Wolf, P. (2008). The effects of sunlight on the skin. Drug Discovery Today: Disease Mechanisms, 5(2), e201-e209. [More Information]
  • Rana, S., Byrne, S., MacDonald, L., Chan, C., Halliday, G. (2008). Ultraviolet B Suppresses Immunity by Inhibiting Effector and Memory T Cells. The American Journal of Pathology: cellular and molecular biology of disease, 172(4), 993-1004. [More Information]

2007

  • Fukunaga, A., Khaskhley, N., Byrne, S., Ullrich, S. (2007). Platelet-activation factor is involved in Langerhans cell migration. Journal of Investigative Dermatology, 127(Supplement 1), S113 (abstract 675)-S113.

2006

  • Matsumura, Y., Byrne, S., Nghiem, D., Miyahara, Y., Ullrich, S. (2006). A role for inflammatory mediators in the induction of immunoregulatory B cells. The Journal of Immunology, 177(7), 4810-4817. [More Information]
  • Wolf, P., Nghiem, D., Walterscheid, J., Byrne, S., Matsumura, Y., Matsumura, Y., Bucana, C., Ananthaswamy, H., Ullrich, S. (2006). Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. The American Journal of Pathology: cellular and molecular biology of disease, 169(3), 795-805. [More Information]
  • Wolf, P., Walterscheid, J., Byrne, S., Nghiem, D., Ananthaswamy, H., Ullrich, S. (2006). Serotonin: Systemic mediator of PUVA-induced immune suppression but not inflammation or apoptosis. Journal of Investigative Dermatology, 126(Supp 3), 70-70.
  • Byrne, S., Spinks, N., Halliday, G. (2006). The induction of immunity to a protein antigen using an adjuvant is significantly compromised by ultraviolet A radiation. Journal of Photochemistry and Photobiology B-Biology, 84(2), 128-134. [More Information]
  • Wolf, P., Byrne, S., Walterscheid, J., Kazimi, N., Ananthaswamy, H., Stephen, U. (2006). UVB and PUVA-induced immune suppression and inflammation in platelet-activating factor (PAF) receptor knock-out mice. Journal of Investigative Dermatology, 126(Supp 1), 136-136.

2005

  • Byrne, S., Halliday, G. (2005). B cells activated in lymph nodes in response to ultraviolet irradiation or by interleukin-10 inhibit dendritic cell induction of immunity. Journal of Investigative Dermatology, 124(3), 570-578. [More Information]
  • Byrne, S., Halliday, G. (2005). B cells activated in lymph nodes in response to ultraviolet-irradiation or by interleukin-10 inhibit dendritic cell induction of immunity. 2nd Annual Meeting of the Australasian-Society for Dermatology Research, United States: Blackwell Publishers.
  • Barnetson, R., Poon, T., Byrne, S., Halliday, G. (2005). Implication of immune protection factor on sunscreen development. 63rd Annual Meeting of the American Academy of Dermatology, United States: Mosby Inc.
  • Barnetson, R., Poon, T., Byrne, S., Halliday, G. (2005). Implication of immune protection factor on sunscreen development. Journal Of The American Academy Of Dermatology, 52(3 Supplement 2), AB9 (Ab# 156-02)-AB9.
  • Weber, F., Byrne, S., Le, S., Brown, D., Breit, S., Scolyer, R., Halliday, G. (2005). Transforming growth factor-b1 immobilises dendritic cells within skin tumours and facilitates tumour escape from the immune system. Cancer Immunology, Immunotherapy: other biological response modifications, 54(9), 898-906. [More Information]
  • Byrne, S., Ahmed, J., Halliday, G. (2005). Ultraviolet B but Not A Radiation Activates Suppressor B Cells in Draining Lymph Nodes. Photochemistry and Photobiology, 81(6), 1366-1370. [More Information]
  • Rana, S., MacDonald, L., Byrne, S., Halliday, G. (2005). Ultraviolet-B radiation inhibits local T cell activation and suppresses the development of memory T cells. Tissue Antigens: immune response genetics, 66(5), 522 (Abstract 492)-522.

2004

  • Halliday, G., Byrne, S., Kuchel, J., Poon, T., Barnetson, R. (2004). The Suppression Of Immunity By Ultraviolet Radiation: Uva, Nitric Oxide And DNA Damage. Photochemical and Photobiological Sciences, 3(8), 736-740.

2003

  • Byrne, S., Halliday, G. (2003). High levels of Fas ligand and MHC class II in the absence of CD80 or CD86 expression and a decreased CD4+ T cell infiltration, enables murine skin tumours to progress. Cancer Immunology, Immunotherapy: other biological response modifications, 52(6), 396-402.
  • Byrne, S., Halliday, G. (2003). Phagocytosis by dendritic cells rather than MHC IIhigh macrophages is associated with skin tumour regression. International Journal of Cancer, 106(5), 736-744. [More Information]
  • Gerzina, T., Worthington, R., Byrne, S., McMahon, C. (2003). Student use and perceptions of different learning aids in a problem-based learning (PBL) dentistry course. Journal of Dental Education, 67(6), 641-653.
  • Stapelberg, M., Halliday, G., Byrne, S. (2003). The role of UVA and UVB in the Modulation of Immunity: Cellular and Chemical Respsonses. Trends in Photochemistry and Photobiology, 10, 103-110.

2002

  • Byrne, S., Halliday, G. (2002). Dendritic cells: making progress with tumour regression? Immunology and Cell Biology, 80(6), 520-530.
  • Halliday, G., Byrne, S. (2002). Ultraviolet A induces immunosuppression, protection or memory enhancement depending on dose, while ultraviolet B is immunosuppresive and tolerogenic over a large dose range. Journal of Photoscience, 9, 197-200.
  • Byrne, S., Spinks, N., Halliday, G. (2002). Ultraviolet A irradiation of C57BL/6 mice suppresses systemic contact hypersensitivity or enhances secondary immunity depending on dose. Journal of Investigative Dermatology, 119(4), 858-864.

2001

  • Byrne, S. (2001). High numbers of infiltrating Langerhans cells in the absence of MHC IIhigh macrophages is associated with skin tumour regression. Journal of Investigative Dermatology, 117(4), 1009.
  • Byrne, S., Halliday, G., Johnston, L., King, N. (2001). Interleukin-1beta But not tumor necrosis factor is involved in West Nile Virus-Induced Langerhans Cell Migration from the Skin in C57BL/6 Mice. Journal of Investigative Dermatology, 117(3), 702-709.

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