Dr Sean Lal

Cardiologist and Clinical Senior Lecturer, Co-Chair Cardiovascular Theme - Sydney Medical School

Lecturer in Visceral Anatomy and Head of the Cardiac Research Laboratory - School of Medical Sciences

Telephone 9351 3209

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Biographical details

BMedSci(Hons), MBBS(Hons), MPhil(Med), PhD(Med), FRACP

Dr Sean Lal is a Clinical Senior Lecturer and Consultant Cardiologist who completed his undergraduate degree in Medical Science with first class honours at the University of Sydney, receiving full academic scholarship. He pursued his graduate Medical Degree (MBBS) and a Master of Medicine by research (MPhil) at the University of Sydney, where he was awarded the Dean's Scholarship, the Medical Foundation Scholarship and the University of Sydney Bercovici Medal. As a medical doctor, Sean completed all of his general and specialty clinical training at Royal Prince Alfred Hospital. As a Cardiology Registrar, he was awarded a National Churchill Fellowship to study mechanisms of cardiac regeneration at Harvard Medical School.

Sean has a clinical and research interest in heart failure, specifically in translational regenerative medicine. For his PhD in this field, he was awarded a combined National Health and Medical Research Council (NHMRC) and National Heart Foundation (NHF) Scholarship, as well as the NHMRC and Royal Australasian College of Physicians (RACP) Award for Excellence. He also received a Commonwealth Endeavour Postgraduate Fellowship to Harvard University and Massachusetts Institute of Technology (MIT), where he undertook proof of concept studies demonstrating the intrinsic regenerative capacity of the human heart.

Sean is a Lecturer in Visceral Anatomy and the Course Coordinator for Cardiac, Endocrine, Abdominal, Pelvic and Renal Anatomy for the Sydney Medical School. He is also the Co-Chair for the Cardiovascular Theme for the MD Program. Sean is a member of the Sydney Heart Bank Executive and he is the Director of the Cardiac Research Laboratory in the School of Medical Sciences, which focuses on basic science and translational research into human heart failure.

Research interests

Our translational research focuses on the human heart. We aim to investigate the molecular basis of cardiomyopathies, cellular changes in ageing, and intrinsic mechanisms of cardiac regeneration.

We uniquely draw on tissue from The Sydney Heart Bank (SHB), which contains over 20,000 cryopreserved human cardiac samples from our collaborations with St Vincent's Hospital (Sydney) and Royal Prince Alfred Hospital.

We have developed an extensive tissue database and international research network with the common goal to further our understanding of human heart failure.

http://sydney.edu.au/medicine/anatomy/research/labs/mru/members/index.php

International links

United States

(Harvard University and Brigham & Women's Hospital, Boston.) Mechanisms of Human Cardiac Regeneration.

Selected grants

2017

  • Developing experimental alternatives to animal models using human heart tissue; Lal S, Li A, Dos Remedios C; Medical Advances Without Animals/Research Grants.

2015

  • The Sydney Human Heart Bank: A resource that eliminates the use of animals in research; Dos Remedios C, King D, Lal S, Li A; Medical Advances Without Animals/Research Grants.

2014

  • MedMAP (Mobile Assessment Platform); O'Mara D, Keay K, Lal S, Rothnie I; DVC Education/Large Educational Innovation Grant.

Selected publications

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Book Chapters

  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.

Journals

  • Crossman, D., Shen, X., Jullig, M., Munro, M., Hou, Y., Middleditch, M., Shrestha, D., Li, A., Lal, S., Dos Remedios, C., et al (2017). Increased collagen within the transverse tubules in human heart failure. Cardiovascular Research, 113(8), 879-891. [More Information]
  • McNamara, J., Li, A., Lal, S., Bos, J., Harris, S., van der Velden, J., Ackerman, M., Cooke, R., Dos Remedios, C. (2017). MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. PloS One, 12(6), 1-22. [More Information]
  • Wang, N., Lal, S. (2017). Post-dilation in transcatheter aortic valve replacement: A systematic review and meta-analysis. Journal of Interventional Cardiology, 30(3), 204-211. [More Information]
  • Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., Macdonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2017). The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 9(4), 431-441. [More Information]
  • McNamara, J., Li, A., Smith, N., Lal, S., Graham, R., Kooiker, K., van Dijk, S., Dos Remedios, C., Harris, S., Cooke, R. (2016). Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology, 94, 65-71. [More Information]
  • Lal, S., Turner, L., Powell, C., Wilson, M., Bannon, P. (2016). Improvements in left ventricular ejection fraction and quality of life in patients with heart failure who undergo coronary artery bypass surgery. International Journal of Cardiology, 222, 671-673. [More Information]
  • Lal, S., Li, A., Dos Remedios, C. (2016). Limitations in Translating Animal Studies to Humans in Cardiovascular Disease. Journal of Cardiovascular Translational Research, 9(2), 165-166. [More Information]
  • Lal, S., Nguyen, L., Tezone, R., Ponten, F., Odeberg, J., Li, A., Dos Remedios, C. (2016). Tissue microarray profiling in human heart failure. Proteomics, 16(17), 2319-2326. [More Information]
  • Lal, S., Li, A., Allen, D., Allen, P., Bannon, P., Cartmill, T., Cooke, R., Farnswoirth, A., Keogh, A., Dos Remedios, C. (2015). Best practice BioBanking of human heart tissue. Biophysical Reviews, 7(4), 399-406. [More Information]
  • Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]
  • Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PloS One, 9(5), 1-11. [More Information]
  • Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung and Circulation, 22(10), 819-826. [More Information]
  • Cahill, H., Jones, A., Herkes, R., Cook, K., Stirling, A., Halbert, T., Yates, A., Lal, S., Gardo, A., Donnelly, R., Gattas, D. (2011). Introduction of a new observation chart and education programme is associated with higher rates of vital-sign ascertainment in hospital wards. BMJ Quality and Safety, 20(9), 791-796. [More Information]
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]
  • Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]
  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]
  • Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]
  • Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149. [More Information]

2017

  • Crossman, D., Shen, X., Jullig, M., Munro, M., Hou, Y., Middleditch, M., Shrestha, D., Li, A., Lal, S., Dos Remedios, C., et al (2017). Increased collagen within the transverse tubules in human heart failure. Cardiovascular Research, 113(8), 879-891. [More Information]
  • McNamara, J., Li, A., Lal, S., Bos, J., Harris, S., van der Velden, J., Ackerman, M., Cooke, R., Dos Remedios, C. (2017). MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. PloS One, 12(6), 1-22. [More Information]
  • Wang, N., Lal, S. (2017). Post-dilation in transcatheter aortic valve replacement: A systematic review and meta-analysis. Journal of Interventional Cardiology, 30(3), 204-211. [More Information]
  • Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., Macdonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2017). The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 9(4), 431-441. [More Information]

2016

  • McNamara, J., Li, A., Smith, N., Lal, S., Graham, R., Kooiker, K., van Dijk, S., Dos Remedios, C., Harris, S., Cooke, R. (2016). Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology, 94, 65-71. [More Information]
  • Lal, S., Turner, L., Powell, C., Wilson, M., Bannon, P. (2016). Improvements in left ventricular ejection fraction and quality of life in patients with heart failure who undergo coronary artery bypass surgery. International Journal of Cardiology, 222, 671-673. [More Information]
  • Lal, S., Li, A., Dos Remedios, C. (2016). Limitations in Translating Animal Studies to Humans in Cardiovascular Disease. Journal of Cardiovascular Translational Research, 9(2), 165-166. [More Information]
  • Lal, S., Nguyen, L., Tezone, R., Ponten, F., Odeberg, J., Li, A., Dos Remedios, C. (2016). Tissue microarray profiling in human heart failure. Proteomics, 16(17), 2319-2326. [More Information]

2015

  • Lal, S., Li, A., Allen, D., Allen, P., Bannon, P., Cartmill, T., Cooke, R., Farnswoirth, A., Keogh, A., Dos Remedios, C. (2015). Best practice BioBanking of human heart tissue. Biophysical Reviews, 7(4), 399-406. [More Information]
  • Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]

2014

  • Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PloS One, 9(5), 1-11. [More Information]

2013

  • Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung and Circulation, 22(10), 819-826. [More Information]

2011

  • Cahill, H., Jones, A., Herkes, R., Cook, K., Stirling, A., Halbert, T., Yates, A., Lal, S., Gardo, A., Donnelly, R., Gattas, D. (2011). Introduction of a new observation chart and education programme is associated with higher rates of vital-sign ascertainment in hospital wards. BMJ Quality and Safety, 20(9), 791-796. [More Information]
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]

2010

  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.
  • Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]

2009

  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]

2004

  • Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]

2002

  • Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149. [More Information]

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