Dr Sean Lal

Cardiologist and Clinical Senior Lecturer

Lecturer in Anatomy and Head of the Cardiac Research Laboratory, School of Medical Sciences

Telephone 9351 3209

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Biographical details

BMedSci(Hons), MBBS(Hons), MPhil(Med), FRACP

Research interests

Our translational research focuses on the human heart. We aim to investigate the molecular basis of cardiomyopathies, cellular changes in ageing, and intrinsic mechanisms of cardiac regeneration.

We uniquely draw on tissue from The Sydney Heart Bank (SHB), which comprises of over 20,000 cryopreserved human cardiac samples from our collaborations with St Vincent's Hospital (Sydney) and Royal Prince Alfred Hospital.

Over the years, we have developed an extensive tissue database and international research network with the common goal to further our understanding of human heart failure.

Selected grants

2015

  • The Sydney Human Heart Bank: A resource that eliminates the use of animals in research; Dos Remedios C, King D, Lal S, Li A; Medical Advances Without Animals/Research Grants.

Selected publications

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Book Chapters

  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.

Journals

  • McNamara, J., Li, A., Smith, N., Lal, S., Graham, R., Kooiker, K., van Dijk, S., Dos Remedios, C., Harris, S., Cooke, R. (2016). Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology, 94, 65-71. [More Information]
  • Lal, S., Turner, L., Powell, C., Wilson, M., Bannon, P. (2016). Improvements in left ventricular ejection fraction and quality of life in patients with heart failure who undergo coronary artery bypass surgery. International Journal of Cardiology, 222, 671-673. [More Information]
  • Lal, S., Li, A., Dos Remedios, C. (2016). Limitations in Translating Animal Studies to Humans in Cardiovascular Disease. Journal of Cardiovascular Translational Research, 9(2), 165-166. [More Information]
  • Lal, S., Li, A., Allen, D., Allen, P., Bannon, P., Cartmill, T., Cooke, R., Farnswoirth, A., Keogh, A., Dos Remedios, C. (2015). Best practice BioBanking of human heart tissue. Biophysical Reviews, 7(4), 399-406. [More Information]
  • Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]
  • Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PloS One, 9(5), 1-11. [More Information]
  • Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung and Circulation, 22(10), 819-826. [More Information]
  • Cahill, H., Jones, A., Herkes, R., Cook, K., Stirling, A., Halbert, T., Yates, A., Lal, S., Gardo, A., Donnelly, R., Gattas, D. (2011). Introduction of a new observation chart and education programme is associated with higher rates of vital-sign ascertainment in hospital wards. BMJ Quality and Safety, 20(9), 791-796. [More Information]
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]
  • Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]
  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]
  • Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]
  • Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149.

2016

  • McNamara, J., Li, A., Smith, N., Lal, S., Graham, R., Kooiker, K., van Dijk, S., Dos Remedios, C., Harris, S., Cooke, R. (2016). Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology, 94, 65-71. [More Information]
  • Lal, S., Turner, L., Powell, C., Wilson, M., Bannon, P. (2016). Improvements in left ventricular ejection fraction and quality of life in patients with heart failure who undergo coronary artery bypass surgery. International Journal of Cardiology, 222, 671-673. [More Information]
  • Lal, S., Li, A., Dos Remedios, C. (2016). Limitations in Translating Animal Studies to Humans in Cardiovascular Disease. Journal of Cardiovascular Translational Research, 9(2), 165-166. [More Information]

2015

  • Lal, S., Li, A., Allen, D., Allen, P., Bannon, P., Cartmill, T., Cooke, R., Farnswoirth, A., Keogh, A., Dos Remedios, C. (2015). Best practice BioBanking of human heart tissue. Biophysical Reviews, 7(4), 399-406. [More Information]
  • Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]

2014

  • Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PloS One, 9(5), 1-11. [More Information]

2013

  • Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung and Circulation, 22(10), 819-826. [More Information]

2011

  • Cahill, H., Jones, A., Herkes, R., Cook, K., Stirling, A., Halbert, T., Yates, A., Lal, S., Gardo, A., Donnelly, R., Gattas, D. (2011). Introduction of a new observation chart and education programme is associated with higher rates of vital-sign ascertainment in hospital wards. BMJ Quality and Safety, 20(9), 791-796. [More Information]
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]

2010

  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.
  • Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]

2009

  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]

2004

  • Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]

2002

  • Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149.

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