Dr Sean Lal

BMedSci(Hons), MBBS(Hons), MPhil(Med), PhD(Med), FRACP

School of Medical Sciences, Sydney Medical School and Royal Prince Alfred Hospital

Telephone 9351 3209

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Biographical details

Dr Sean Lal is a Clinical Academic Cardiologist at the University of Sydney and Royal Prince Alfred Hospital. He completed his undergraduate degree in Medical Science with first class honours at the University of Sydney, receiving full academic scholarship. He pursued his graduate Medical Degree (MBBS) and a Master of Medicine by research (MPhil) at the University of Sydney, where he was awarded the Dean's Scholarship, the Medical Foundation Scholarship and the University of Sydney Bercovici Medal. As a medical doctor, Sean completed all of his general and specialty clinical training at Royal Prince Alfred Hospital. During his cardiology training, he was awarded a National Churchill Fellowship to study mechanisms of cardiac regeneration at Harvard Medical School.

Sean has a clinical and research interest in heart failure. For his PhD in this field, he was awarded a combined National Health and Medical Research Council (NHMRC) and National Heart Foundation (NHF) Scholarship, as well as the NHMRC and Royal Australasian College of Physicians (RACP) scholarship for research excellence.

He was also awarded a Commonwealth Endeavour Postgraduate Fellowship to Harvard University and Massachusetts Institute of Technology (MIT), where he undertook proof of concept studies demonstrating the intrinsic regenerative capacity of the human heart following myocardial infarction.

Sean is Block Chair for Cardiovascular Medicine. He is also a Lecturer in Visceral Anatomy and the Course Coordinator for Cardiac, Endocrine, Abdominal, Pelvic and Renal Anatomy for the Sydney Medical (MD) Program. He is also the Course Coordinator for ANAT2011 in the Faculty of Science.

Sean is a Co-Director of the Sydney Heart Bank and the Head of the Cardiac Research Laboratory in the School of Medical Sciences, which focuses on basic science and translational research into human heart failure. He is also the Theme Leader for Cardiovascular Research in the Bosch Institute, Sydney Medical School.

In a collaboration with Dr John O'Sullivan from the Charles Perkins Centre, Sean and John have established the Precision Cardiovascular Laboratory, which aims to correlate serum biomarkers of cardiovascular disease with pathogenic and age-related changes in human heart tissue via integration of the cardiac genome, transcriptome, metabolome and proteome.

Research interests

Our translational research focuses on the human heart. We aim to investigate the molecular basis of cardiomyopathies, cellular changes in ageing, and intrinsic mechanisms of cardiac regeneration.

We uniquely draw on tissue from The Sydney Heart Bank (SHB), which contains over 20,000 cryopreserved human cardiac samples from our collaborations with St Vincent's Hospital (Sydney), the Australian Red Cross Donor Service and Royal Prince Alfred Hospital.

We have developed an extensive tissue database and international research network with the common goal to further our understanding of human heart failure.

http://sydney.edu.au/medicine/anatomy/research/labs/mru/members/index.php

International links

United States

(Harvard University and Brigham & Women's Hospital, Boston.) Mechanisms of Human Cardiac Regeneration.

Selected grants

2017

  • Developing experimental alternatives to animal models using human heart tissue; Lal S, Li A, Dos Remedios C; Medical Advances Without Animals/Research Grants.

2015

  • The Sydney Human Heart Bank: A resource that eliminates the use of animals in research; Dos Remedios C, King D, Lal S, Li A; Medical Advances Without Animals/Research Grants.

2014

  • MedMAP (Mobile Assessment Platform); O'Mara D, Keay K, Lal S, Rothnie I; DVC Education/Large Educational Innovation Grant.

Selected publications

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Book Chapters

  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.

Journals

  • Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., MacDonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2018). Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 10(3), 941. [More Information]
  • Lal, S., Kotchetkova, I., Cao, J., Jackson, D., Cordina, R., Celermajer, D. (2018). Heart failure admissions and poor subsequent outcomes in adults with congenital heart disease. European Journal of Heart Failure, 20(4), 812-815. [More Information]
  • Dos Remedios, C., Li, A., Lal, S. (2018). Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective. Biophysical Reviews, 10(4), 949-954. [More Information]
  • Wang, N., Fulcher, J., Abeysuriya, N., Adams, M., Lal, S. (2018). Predictors of successful chronic total occlusion percutaneous coronary interventions: a systematic review and meta-analysis. Heart, 104(6), 517-524. [More Information]
  • Lal, S. (2018). Primary Sjogren?s Syndrome. New England Journal of Medicine, 379(1), 96-97.
  • Cao, J., Lee, S., Phan, K., Celermajer, D., Lal, S. (2018). Renin-angiotensin-aldosterone inhibition improves right ventricular function: a meta-analysis. Heart Asia, 10(1), 1-7. [More Information]
  • Bagnall, R., Ingles, J., Dinger, M., Cowley, M., Ross, S., Minoche, A., Lal, S., Turner, C., Colley, A., Rajagopalan, S., Semsarian, C., et al (2018). Whole Genome Sequencing Improves Outcomes of Genetic Testing in Patients With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 72(4), 419-429. [More Information]
  • Vikhorev, P., Smoktunowicz, N., Munster, A., Copeland, O., Kostin, S., Montgiraud, C., Messer, A., Toliat, M., Li, A., Dos Remedios, C., Lal, S., et al (2017). Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes. Scientific Reports, 7(1), 1-11. [More Information]
  • Mamidi, R., Li, J., Gresham, K., Verma, S., Doh, C., Li, A., Lal, S., Dos Remedios, C., Stelzer, J. (2017). Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium. Circulation. Heart Failure, 10(10), 1-11. [More Information]
  • Crossman, D., Shen, X., Jullig, M., Munro, M., Hou, Y., Middleditch, M., Shrestha, D., Li, A., Lal, S., Dos Remedios, C., et al (2017). Increased collagen within the transverse tubules in human heart failure. Cardiovascular Research, 113(8), 879-891. [More Information]
  • McNamara, J., Li, A., Lal, S., Bos, J., Harris, S., van der Velden, J., Ackerman, M., Cooke, R., Dos Remedios, C. (2017). MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. PloS One, 12(6), 1-22. [More Information]
  • Wang, N., Lal, S. (2017). Post-dilation in transcatheter aortic valve replacement: A systematic review and meta-analysis. Journal of Interventional Cardiology, 30(3), 204-211. [More Information]
  • Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., Macdonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2017). The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 9(4), 431-441. [More Information]
  • McNamara, J., Li, A., Smith, N., Lal, S., Graham, R., Kooiker, K., van Dijk, S., Dos Remedios, C., Harris, S., Cooke, R. (2016). Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology, 94, 65-71. [More Information]
  • Lal, S., Turner, L., Powell, C., Wilson, M., Bannon, P. (2016). Improvements in left ventricular ejection fraction and quality of life in patients with heart failure who undergo coronary artery bypass surgery. International Journal of Cardiology, 222, 671-673. [More Information]
  • Lal, S., Li, A., Dos Remedios, C. (2016). Limitations in Translating Animal Studies to Humans in Cardiovascular Disease. Journal of Cardiovascular Translational Research, 9(2), 165-166. [More Information]
  • Lal, S., Nguyen, L., Tezone, R., Ponten, F., Odeberg, J., Li, A., Dos Remedios, C. (2016). Tissue microarray profiling in human heart failure. Proteomics, 16(17), 2319-2326. [More Information]
  • Lal, S., Li, A., Allen, D., Allen, P., Bannon, P., Cartmill, T., Cooke, R., Farnswoirth, A., Keogh, A., Dos Remedios, C. (2015). Best practice BioBanking of human heart tissue. Biophysical Reviews, 7(4), 399-406. [More Information]
  • Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]
  • Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PloS One, 9(5), 1-11. [More Information]
  • Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung and Circulation, 22(10), 819-826. [More Information]
  • Cahill, H., Jones, A., Herkes, R., Cook, K., Stirling, A., Halbert, T., Yates, A., Lal, S., Gardo, A., Donnelly, R., Gattas, D. (2011). Introduction of a new observation chart and education programme is associated with higher rates of vital-sign ascertainment in hospital wards. BMJ Quality and Safety, 20(9), 791-796. [More Information]
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]
  • Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]
  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]
  • Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]
  • Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149. [More Information]

2018

  • Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., MacDonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2018). Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 10(3), 941. [More Information]
  • Lal, S., Kotchetkova, I., Cao, J., Jackson, D., Cordina, R., Celermajer, D. (2018). Heart failure admissions and poor subsequent outcomes in adults with congenital heart disease. European Journal of Heart Failure, 20(4), 812-815. [More Information]
  • Dos Remedios, C., Li, A., Lal, S. (2018). Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective. Biophysical Reviews, 10(4), 949-954. [More Information]
  • Wang, N., Fulcher, J., Abeysuriya, N., Adams, M., Lal, S. (2018). Predictors of successful chronic total occlusion percutaneous coronary interventions: a systematic review and meta-analysis. Heart, 104(6), 517-524. [More Information]
  • Lal, S. (2018). Primary Sjogren?s Syndrome. New England Journal of Medicine, 379(1), 96-97.
  • Cao, J., Lee, S., Phan, K., Celermajer, D., Lal, S. (2018). Renin-angiotensin-aldosterone inhibition improves right ventricular function: a meta-analysis. Heart Asia, 10(1), 1-7. [More Information]
  • Bagnall, R., Ingles, J., Dinger, M., Cowley, M., Ross, S., Minoche, A., Lal, S., Turner, C., Colley, A., Rajagopalan, S., Semsarian, C., et al (2018). Whole Genome Sequencing Improves Outcomes of Genetic Testing in Patients With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 72(4), 419-429. [More Information]

2017

  • Vikhorev, P., Smoktunowicz, N., Munster, A., Copeland, O., Kostin, S., Montgiraud, C., Messer, A., Toliat, M., Li, A., Dos Remedios, C., Lal, S., et al (2017). Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes. Scientific Reports, 7(1), 1-11. [More Information]
  • Mamidi, R., Li, J., Gresham, K., Verma, S., Doh, C., Li, A., Lal, S., Dos Remedios, C., Stelzer, J. (2017). Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium. Circulation. Heart Failure, 10(10), 1-11. [More Information]
  • Crossman, D., Shen, X., Jullig, M., Munro, M., Hou, Y., Middleditch, M., Shrestha, D., Li, A., Lal, S., Dos Remedios, C., et al (2017). Increased collagen within the transverse tubules in human heart failure. Cardiovascular Research, 113(8), 879-891. [More Information]
  • McNamara, J., Li, A., Lal, S., Bos, J., Harris, S., van der Velden, J., Ackerman, M., Cooke, R., Dos Remedios, C. (2017). MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. PloS One, 12(6), 1-22. [More Information]
  • Wang, N., Lal, S. (2017). Post-dilation in transcatheter aortic valve replacement: A systematic review and meta-analysis. Journal of Interventional Cardiology, 30(3), 204-211. [More Information]
  • Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., Macdonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2017). The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 9(4), 431-441. [More Information]

2016

  • McNamara, J., Li, A., Smith, N., Lal, S., Graham, R., Kooiker, K., van Dijk, S., Dos Remedios, C., Harris, S., Cooke, R. (2016). Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology, 94, 65-71. [More Information]
  • Lal, S., Turner, L., Powell, C., Wilson, M., Bannon, P. (2016). Improvements in left ventricular ejection fraction and quality of life in patients with heart failure who undergo coronary artery bypass surgery. International Journal of Cardiology, 222, 671-673. [More Information]
  • Lal, S., Li, A., Dos Remedios, C. (2016). Limitations in Translating Animal Studies to Humans in Cardiovascular Disease. Journal of Cardiovascular Translational Research, 9(2), 165-166. [More Information]
  • Lal, S., Nguyen, L., Tezone, R., Ponten, F., Odeberg, J., Li, A., Dos Remedios, C. (2016). Tissue microarray profiling in human heart failure. Proteomics, 16(17), 2319-2326. [More Information]

2015

  • Lal, S., Li, A., Allen, D., Allen, P., Bannon, P., Cartmill, T., Cooke, R., Farnswoirth, A., Keogh, A., Dos Remedios, C. (2015). Best practice BioBanking of human heart tissue. Biophysical Reviews, 7(4), 399-406. [More Information]
  • Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]

2014

  • Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PloS One, 9(5), 1-11. [More Information]

2013

  • Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung and Circulation, 22(10), 819-826. [More Information]

2011

  • Cahill, H., Jones, A., Herkes, R., Cook, K., Stirling, A., Halbert, T., Yates, A., Lal, S., Gardo, A., Donnelly, R., Gattas, D. (2011). Introduction of a new observation chart and education programme is associated with higher rates of vital-sign ascertainment in hospital wards. BMJ Quality and Safety, 20(9), 791-796. [More Information]
  • Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]

2010

  • Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.
  • Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]

2009

  • Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]

2004

  • Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]

2002

  • Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149. [More Information]

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