Professor Shaun Jackson

Director of Cardiovascular Research, Heart Research Institute
Charles Perkins Centre

Telephone +61 3 9903 0147

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Biographical details

Professor Shaun Jackson was recently appointed as Director of Cardiovascular Research, a joint initiative between the Heart Research Institute (NSW) and the Charles Perkins Centre (the University of Sydney). In addition to this role, he holds several other titles and adjunct roles, including: Australia Fellow, National Health and Medical Research Council (NHMRC) of Australia (2010-2014), Adjunct Professor, Dept. Molecular and Experimental Medicine, The Scripps Research Institute, San Diego, USA (2009-current) and Adjunct Professor, Monash University (2014-current).

Professor Jackson established his research team at the Monash University Department of Medicine at Box Hill Hospital in Melbourne Victoria, in 1998. Together with the Head of Department, Professor Hatem Salem, he founded the Australian Centre for Blood Diseases (ACBD), for which he was appointed Research Director. In 2004, the ACBD relocated to the Alfred Hospital in Melbourne, as part of the Alfred Medical Research and Education Precinct (AMREP). In 2014, Shaun was appointed to his current role, as Director of Cardiovascular Research (HRI/CPC) in Sydney, NSW.

Many of Shaun’s senior-author publications are in leading international journals including Nature Medicine, Nature Cell Biology, Journal of Cell Biology, PNAS, Nature Communications, and Journal of Clinical Investigation. His papers have been cited by the Faculty of 1000, with several nominated in the highest ‘Exceptional’ and ‘Must Read’ categories. Adept in translational research, Shaun co-founded a biotechnology company, Kinacia P.L., which performed the first Phase I human clinical study on PI 3-kinase inhibitors for development as novel anti-platelets. These inhibitors were subsequently purchased by Astra Zeneca for ongoing clinical development.

Research interests

Atherothrombosis is arguably Australia’s major healthcare problem, affecting >50% of the adult population. In particular, the development of arterial thrombosis in the coronary or cerebral circulation (causing acute myocardial infarction and ischaemic stroke, respectively) is a major clinical problem, responsible for more deaths in the community than any other disease process. Despite intense investigation over the last 40 years into the discovery and development of more effective antithrombotic drugs, the impact of these therapies on mortality rates has remained disappointingly low, with less than 1 in 6 patients taking antithrombotic therapies avoiding a fatal thrombotic event. This situation is likely to worsen in the future due to the rapidly growing incidence of obesity, diabetes and the metabolic syndrome. These diseases are typically more resistant to the benefits of antithrombotic therapy, thus there is a pressing need for the identification and development of more effective approaches. Research undertaken in our laboratory is focussed on understanding the mechanisms causing platelet hyperactivity in diabetes and the metabolic syndrome, with the aim of developing innovative new approaches to reduce thrombosis risk in these diseases. We are specifically interested in the biochemical and biophysical regulators (rheology) of platelet activity and function, including influence of specific signalling pathways such as PI 3-kinase and cell death pathways linked to apoptosis and necrosis. We are also actively examining new pathways that control the proinflammatory function of platelets linked to cardiovascular diseases.

Current projects

•· Investigating the role of cell death pathways in regulating the proinflammatory function of platelets and leukocytes during ischaemia-reperfusion injury
  • Investigating the role of cell death pathways in regulating the proinflammatory function of platelets and leukocytes during ischaemia-reperfusion injury
  • Identifying new pathways regulating platelet hyperactivity and thrombosis in diabetes
  • Identifying novel approaches to facilitate blood clot dissolution
platelets and leukocytes during ischaemia-reperfusion injury
• Identifying new pathways regulating platelet hyperactivity and thrombosis in diabetes
• Identifying novel approaches to facilitate blood clot dissolution

Awards and honours

2011 Investigator Recognition Award & Medal,Awarded by the International Society on Thrombosis and Haemostasis

2010 Australia Fellowship, NHMRC

2009 Marion Barnhart Prize, Awarded by the International Society on Thrombosis and Haemostasis

2004 Rudolph Virchow Medal, Wurzburg, Germany

2001 Silver Jubilee Research Prize, Monash University

1995 Inaugural Premier's Award for Excellence in Medical Research

International links

Australia

(Baker IDI, Victoria) Professor Mark Cooper

France

(INSERM U949, EFS-Alsace, Strasbourg) Professor François Lanza

United States

(Georgia Institute of Technology, Atlanta) Professor Cheng Zhu

United States

(The Scripps Research Institute, San Diego) Professor Zaverio Ruggeri, Dept. Molecular and Experimental Medicine

Selected grants

2015

  • Investigating a potential new treatment for stroke; Jackson S; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • PI3Kbeta and blood clot porosity; Schoenwaelder S, Jackson S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Spinning Disk Confocal System for Ultra-High Speed Imaging; James D, Braet F, Jackson S, Bilek M, Overall R; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2014

  • A new role for growth factor c-mpl in blood clot formation; Jackson S, Schoenwaelder S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Tractopods - Novel structures regulating platelet-vessel wall interactions; Jackson S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Development of an Ultra-High Speed Spinning Disk Confocal micro-PIV Platform for the Investigation of Cardiovascular Disease; Jackson S, Mitchell A, Cooper M, Tovar F; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2013

  • Investigation of the proinflammatory function of platelets during ischaemia-reperfusion injury; Jackson S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Investigation of a novel mechanism causing platelet hyperactivity in diabetes; Jackson S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Australia Fellowship; Jackson S; National Health and Medical Research Council (NHMRC)/Career Awards: Australian Fellowship.
  • Investigating thrombo-inflammatory responses; Jackson S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Ruggeri, Z., Jackson, S. (2013). Platelet Thrombus Formation in Flowing Blood. In Alan D Michelson (Eds.), Platelets, (pp. 399-424). London, UK: Elsevier.

Journals

  • Mountford, J., Petitjean, C., Putra, H., McCafferty, J., Setiabakti, N., Lee, H., Tønnesen, L., McFadyen, J., Schoenwaelder, S., Eckly, A., Jackson, S., et al (2015). The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nature Communications, 6, 6535. [More Information]
  • Hughan, S., Spring, C., Schoenwaelder, S., Sturgeon, S., Alwis, I., Yuan, Y., McFadyen, J., Westein, E., Goddard, D., Ono, A., Jackson, S., et al (2014). Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrinαIIbβ3 in mice. The Journal of Biological Chemistry, 289(8), 5051-5060. [More Information]
  • Luo, L., Wall, A., Yeo, J., Condon, N., Norwood, S., Schoenwaelder, S., Chen, K., Jackson, S., Jenkins, B., Hartland, E., et al (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5, 1-13. [More Information]
  • Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S., Ashworth, K., Westein, E., Hosseini, E., Salem, H., Slattery, R., McColl, S., et al (2013). The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood, 121(22), 4555-4566. [More Information]
  • Al-Tamimi, M., Tan, C., Qiao, J., Pennings, G., Javadzadegan, A., Yong, A., Arthur, J., Davis, A., Jing, J., Mu, F., Ward, C., Kritharides, L., et al (2012). Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood, 119(18), 4311-4320. [More Information]
  • Jackson, S. (2011). Arterial thrombosis-insidious, unpredictable and deadly. Nature Medicine, 17(11), 1423-1436. [More Information]
  • Cranmer, S., Ashworth, K., Yao, Y., Berndt, M., Ruggeri, Z., Andrews, R., Jackson, S. (2011). High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood, 117(9), 2718-2727. [More Information]
  • Nesbitt, W., Westein, E., Tovar-Lopez, F., Tolouei, E., Mitchell, A., Fu, J., Carberry, J., Fouras, A., Jackson, S. (2009). A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nature Medicine, 15(6), 665-673. [More Information]
  • Calkin, A., Drew, B., Ono, A., Duffy, S., Gordon, M., Schoenwaelder, S., Sviridov, D., Cooper, M., Kingwell, B., Jackson, S. (2009). Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation, 120(21), 2095-2104. [More Information]

2015

  • Mountford, J., Petitjean, C., Putra, H., McCafferty, J., Setiabakti, N., Lee, H., Tønnesen, L., McFadyen, J., Schoenwaelder, S., Eckly, A., Jackson, S., et al (2015). The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nature Communications, 6, 6535. [More Information]

2014

  • Hughan, S., Spring, C., Schoenwaelder, S., Sturgeon, S., Alwis, I., Yuan, Y., McFadyen, J., Westein, E., Goddard, D., Ono, A., Jackson, S., et al (2014). Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrinαIIbβ3 in mice. The Journal of Biological Chemistry, 289(8), 5051-5060. [More Information]
  • Luo, L., Wall, A., Yeo, J., Condon, N., Norwood, S., Schoenwaelder, S., Chen, K., Jackson, S., Jenkins, B., Hartland, E., et al (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5, 1-13. [More Information]

2013

  • Ruggeri, Z., Jackson, S. (2013). Platelet Thrombus Formation in Flowing Blood. In Alan D Michelson (Eds.), Platelets, (pp. 399-424). London, UK: Elsevier.
  • Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S., Ashworth, K., Westein, E., Hosseini, E., Salem, H., Slattery, R., McColl, S., et al (2013). The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood, 121(22), 4555-4566. [More Information]

2012

  • Al-Tamimi, M., Tan, C., Qiao, J., Pennings, G., Javadzadegan, A., Yong, A., Arthur, J., Davis, A., Jing, J., Mu, F., Ward, C., Kritharides, L., et al (2012). Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood, 119(18), 4311-4320. [More Information]

2011

  • Jackson, S. (2011). Arterial thrombosis-insidious, unpredictable and deadly. Nature Medicine, 17(11), 1423-1436. [More Information]
  • Cranmer, S., Ashworth, K., Yao, Y., Berndt, M., Ruggeri, Z., Andrews, R., Jackson, S. (2011). High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood, 117(9), 2718-2727. [More Information]

2009

  • Nesbitt, W., Westein, E., Tovar-Lopez, F., Tolouei, E., Mitchell, A., Fu, J., Carberry, J., Fouras, A., Jackson, S. (2009). A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nature Medicine, 15(6), 665-673. [More Information]
  • Calkin, A., Drew, B., Ono, A., Duffy, S., Gordon, M., Schoenwaelder, S., Sviridov, D., Cooper, M., Kingwell, B., Jackson, S. (2009). Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation, 120(21), 2095-2104. [More Information]

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