Dr Shounan Yi

Senior Research Fellow
Medicine, Westmead Clinical School
The Westmead Institute for Medical Research

Telephone +61 2 9845 6877
Fax +61 2 9633 9351

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Biographical details

Dr. Shounan Yi is senior research fellow and leads a cellular immunotherapy research group at the Westmead Institute of Medical Research. He receives his medical degree in China in 1982 and PhD in UNSW in 1996. He is a leading researcher in islet xenotransplantation studies and has longstanding research interest and expertise in transplantation immunology. He has developed and refined many of the techniques that are currently in use in the study of xenotransplantation. Since 1997 he has been involved in various collaborative projects as a chief or an associate investigator in xenotransplantation research with St Vincent’s Hospital Melbourne, Walter & Eliza Hall Institute, Adelaide University and Central South University in China.

He is a medical graduate committed to research and has great interest in translation of his research into the clinic, in particular, regulatory T cell (Treg)-based immunotherapy in (xeno)transplantation. He has been involved as a co-investigator and/or senior scientific advisor in the first clinical trial for islet xenotransplantation, and several pilot regulatory cell-based therapy clinical trials in autoimmune disease and living donor kidney transplantation in China.

Research interests

Dr Yi’s research interest is to develop and translate regulatory cell-based immunotherapies for clinical application in transplantation tolerance and autoimmune diseases.

Teaching and supervision

Supervising honours, master and PhD students

Current projects

1. Developing tolerance induction strategies for cellular immunotherapy in islet and kidney transplantation.

2.Type 1diabetes pathology, prevention and treatment.

3. Expanding the criteria for human islet transplantation by the development of a drug-free immunosuppression protocol.

Associations

Dr Yiis postgraduate supervisor at the University of Sydney since 1998 and is a regular reviewer for several international journals and national grants. He has been appointed as visiting or guest professor by a number of universities and medical institutions in China, including those in top 20 Chinese universities since 2000.

Selected grants

2014

  • Transplantation of pig islets to treat diabetes; Cowan P, Hawthorne W, Yi S, Nottle M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Therapeutic potential of peritoneal mononuclear phagocytes from peritoneal dialysis patients; Wang Y, Harris D, Yi S; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Jin, X., Lu, Y., Zhao, Y., Yi, S. (2016). Large-scale in vitro expansion of human regulatory T cells with potent xenoantigen-specific suppression. Cytotechnology, 68(4), 935-945. [More Information]
  • O'Connell, P., Yi, S. (2016). Response to comment on Yi et al.: Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice. Diabetes 2012; 61: 1180-1191. Diabetes, 65(2), e9-e10. [More Information]
  • Song, Y., Xu, C., Shao, S., Liu, J., Xing, W., Xu, J., Qin, C., Liu, C., Hu, B., Yi, S., et al (2015). Thyroid-stimulating hormone (TSH) regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis. Journal of Hepatology, 62(5), 1171-1179. [More Information]
  • Zhao, R., Tang, D., Yi, S., Li, W., Wu, C., Lu, Y., Hou, X., Song, J., Lin, P., Chen, L., et al (2014). Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type 2 diabetes. PloS One, 9(1), 1-9. [More Information]
  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation, 97(1), 30-38. [More Information]
  • Zhao, R., Li, W., Lu, Y., Qin, J., Wu, C., Tian, M., He, T., Yi, S., Tang, D., Sun, L., et al (2014). Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients. Mediators of Inflammation, 2014, 1-12. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • O'Connell, P., Cowan, P., Hawthorne, W., Yi, S., Lew, A. (2013). Transplantation of Xenogeneic Islets: Are We There Yet? Current Diabetes Reports, 13(5), 687-694. [More Information]
  • Ji, M., Jin, X., Phillips, P., Yi, S. (2012). A humanized mouse model to study human immune response in xenotransplantation. Hepatobiliary & Pancreatic Diseases International, 11(5), 494-498. [More Information]
  • Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P., Hawthorne, W., O'Connell, P. (2012). Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes, 61(5), 1180-1191. [More Information]
  • Sun, L., Wu, J., Yi, S. (2012). Foxp3 is critical for human natural CD4+CD25+ regulatory T cells to suppress alloimmune response. Transplant Immunology, 26(2-3), 71-80. [More Information]
  • O'Connell, P., Yi, S., Carrington, E., Lew, A. (2010). Role of regulatory T cells in xenotransplantation. Current Opinion in Organ Transplantation, 15(2), 224-229. [More Information]
  • Hawthorne, W., Xing, X., Yi, S., Simond, D., Dong, Q., Ye, B., Tong, Q., Ye, Z., Wang, W. (2009). Investigation of porcine endogenous retrovirus in the conservation population of ningxiang pig. Transplantation Proceedings, 41(10), 4389-4393. [More Information]
  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'Connell, P. (2008). In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation, 85(12), 1841-1848. [More Information]
  • Chandra, A., Ouyang, L., Wong, J., Ha, H., Walters, S., Patel, A., Hawthorne, W., Yi, S. (2007). Association between islet xenograft rejection mediated by activated macrophages and upregulated chemokines. Zhongnan Daxue Xuebao (Yixue Ban), 32(1), 26-35. [More Information]
  • Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha, H., Walters, S., Patel, A., Stokes, R., Jardine, M., Hawthorne, W., O'Connell, P. (2007). Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection. Xenotransplantation, 14(1), 48-59. [More Information]
  • Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J., Ouyang, L., Burgess, J., Hawthorne, W., Wu, H., Chadban, S., O'Connell, P. (2007). Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation, 83(5), 615-623. [More Information]
  • Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra, A., Akima, S., Hawthorne, W., Patel, A., Stokes, R., O'Connell, P. (2005). Involvement of CCR5 Signaling in Macrophage Recruitment to Porcine Islet Xenografts. Transplantation, 80(10), 1468-1475. [More Information]
  • Yi, S., Hawthorne, W., Lehnert, A., Ha, H., Wong, J., Rooijen, N., Davey, K., Patel, A., Walters, S., Chandra, A., O'Connell, P. (2003). T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts. The Journal of Immunology, 170(5), 2750-2758.

2016

  • Jin, X., Lu, Y., Zhao, Y., Yi, S. (2016). Large-scale in vitro expansion of human regulatory T cells with potent xenoantigen-specific suppression. Cytotechnology, 68(4), 935-945. [More Information]
  • O'Connell, P., Yi, S. (2016). Response to comment on Yi et al.: Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice. Diabetes 2012; 61: 1180-1191. Diabetes, 65(2), e9-e10. [More Information]

2015

  • Song, Y., Xu, C., Shao, S., Liu, J., Xing, W., Xu, J., Qin, C., Liu, C., Hu, B., Yi, S., et al (2015). Thyroid-stimulating hormone (TSH) regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis. Journal of Hepatology, 62(5), 1171-1179. [More Information]

2014

  • Zhao, R., Tang, D., Yi, S., Li, W., Wu, C., Lu, Y., Hou, X., Song, J., Lin, P., Chen, L., et al (2014). Elevated peripheral frequencies of Th22 cells: a novel potent participant in obesity and type 2 diabetes. PloS One, 9(1), 1-9. [More Information]
  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation, 97(1), 30-38. [More Information]
  • Zhao, R., Li, W., Lu, Y., Qin, J., Wu, C., Tian, M., He, T., Yi, S., Tang, D., Sun, L., et al (2014). Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients. Mediators of Inflammation, 2014, 1-12. [More Information]

2013

  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • O'Connell, P., Cowan, P., Hawthorne, W., Yi, S., Lew, A. (2013). Transplantation of Xenogeneic Islets: Are We There Yet? Current Diabetes Reports, 13(5), 687-694. [More Information]

2012

  • Ji, M., Jin, X., Phillips, P., Yi, S. (2012). A humanized mouse model to study human immune response in xenotransplantation. Hepatobiliary & Pancreatic Diseases International, 11(5), 494-498. [More Information]
  • Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P., Hawthorne, W., O'Connell, P. (2012). Adoptive Transfer With In Vitro Expanded Human Regulatory T Cells Protects Against Porcine Islet Xenograft Rejection via Interleukin-10 in Humanized Mice. Diabetes, 61(5), 1180-1191. [More Information]
  • Sun, L., Wu, J., Yi, S. (2012). Foxp3 is critical for human natural CD4+CD25+ regulatory T cells to suppress alloimmune response. Transplant Immunology, 26(2-3), 71-80. [More Information]

2010

  • O'Connell, P., Yi, S., Carrington, E., Lew, A. (2010). Role of regulatory T cells in xenotransplantation. Current Opinion in Organ Transplantation, 15(2), 224-229. [More Information]

2009

  • Hawthorne, W., Xing, X., Yi, S., Simond, D., Dong, Q., Ye, B., Tong, Q., Ye, Z., Wang, W. (2009). Investigation of porcine endogenous retrovirus in the conservation population of ningxiang pig. Transplantation Proceedings, 41(10), 4389-4393. [More Information]

2008

  • Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond, D., Wang, W., Wang, Y., Hawthorne, W., O'Connell, P. (2008). In Vitro Expanded Human CD4+CD25+ Regulatory T Cells are Potent Suppressors of T-Cell-Mediated Xenogeneic Responses. Transplantation, 85(12), 1841-1848. [More Information]

2007

  • Chandra, A., Ouyang, L., Wong, J., Ha, H., Walters, S., Patel, A., Hawthorne, W., Yi, S. (2007). Association between islet xenograft rejection mediated by activated macrophages and upregulated chemokines. Zhongnan Daxue Xuebao (Yixue Ban), 32(1), 26-35. [More Information]
  • Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha, H., Walters, S., Patel, A., Stokes, R., Jardine, M., Hawthorne, W., O'Connell, P. (2007). Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection. Xenotransplantation, 14(1), 48-59. [More Information]
  • Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J., Ouyang, L., Burgess, J., Hawthorne, W., Wu, H., Chadban, S., O'Connell, P. (2007). Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer. Transplantation, 83(5), 615-623. [More Information]

2005

  • Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra, A., Akima, S., Hawthorne, W., Patel, A., Stokes, R., O'Connell, P. (2005). Involvement of CCR5 Signaling in Macrophage Recruitment to Porcine Islet Xenografts. Transplantation, 80(10), 1468-1475. [More Information]

2003

  • Yi, S., Hawthorne, W., Lehnert, A., Ha, H., Wong, J., Rooijen, N., Davey, K., Patel, A., Walters, S., Chandra, A., O'Connell, P. (2003). T Cell-Activated Macrophages Are Capable of Both Recognition and Rejection of Pancreatic Islet Xenografts. The Journal of Immunology, 170(5), 2750-2758.

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